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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for UCHL1 |
 Gene summary |
| Gene information | Gene symbol | UCHL1 | Gene ID | 7345 |
| Gene name | ubiquitin C-terminal hydrolase L1 | |
| Synonyms | HEL-117|HEL-S-53|NDGOA|PARK5|PGP 9.5|PGP9.5|PGP95|SPG79|Uch-L1 | |
| Cytomap | 4p13 | |
| Type of gene | protein-coding | |
| Description | ubiquitin carboxyl-terminal hydrolase isozyme L1epididymis luminal protein 117epididymis secretory protein Li 53neuron cytoplasmic protein 9.5ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)ubiquitin thioesterase L1ubiquitin thioles | |
| Modification date | 20200329 | |
| UniProtAcc | P09936, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| UCHL1 | GO:0016579 | protein deubiquitination | 9521656 |
| UCHL1 | GO:0043407 | negative regulation of MAP kinase activity | 19477270 |
Top |
RNA A-to-I events for UCHL1 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_1135819(41262190, +), ADediting_1135820(41262198, +), ADediting_1135821(41262207, +), ADediting_1135822(41262212, +), ADediting_1135823(41262213, +), ADediting_1135824(41262216, +), ADediting_1135825(41262242, +), ADediting_1135826(41262247, +), ADediting_1135827(41262252, +), ADediting_1135828(41262261, +), ADediting_1135829(41262263, +), ADediting_1135830(41262266, +), ADediting_1135831(41262276, +), ADediting_1135832(41262278, +), ADediting_1135833(41262280, +), ADediting_1135834(41262284, +), ADediting_1135835(41262285, +), ADediting_1135836(41262286, +), ADediting_1135837(41262325, +), ADediting_1135838(41262331, +), ADediting_1135839(41262335, +), ADediting_1135840(41262391, +), ADediting_1135841(41262652, +), ADediting_1135842(41262671, +), ADediting_1135843(41262679, +), ADediting_1135844(41262736, +), ADediting_1135845(41262791, +), ADediting_1135846(41262803, +), ADediting_1135847(41262806, +), ADediting_1135848(41262815, +), ADediting_1135849(41262842, +), ADediting_1135850(41262843, +), ADediting_1135851(41262860, +), ADediting_1135852(41262870, +), ADediting_1135853(41262876, +), ADediting_1135854(41263078, +), ADediting_1135855(41265301, +), ADediting_1135856(41265321, +), ADediting_1135857(41265324, +), ADediting_1135858(41265329, +), ADediting_1135859(41265363, +), ADediting_1135860(41265368, +), ADediting_1135861(41265376, +), ADediting_1135862(41265377, +), ADediting_1135863(41265392, +), ADediting_1135864(41265393, +), ADediting_1135865(41265394, +), ADediting_1135866(41265413, +), ADediting_1135867(41265416, +), ADediting_1135868(41265417, +), ADediting_1135869(41265418, +), ADediting_1135870(41265419, +), ADediting_1135871(41265422, +), ADediting_1135872(41265425, +), ADediting_1135873(41265426, +), ADediting_1135874(41265427, +), ADediting_1135875(41265428, +), ADediting_1135876(41265431, +), ADediting_1135877(41265435, +), ADediting_1135878(41265449, +), ADediting_1135879(41265463, +), ADediting_1135880(41265480, +), ADediting_1135881(41265487, +), ADediting_1135882(41265490, +), ADediting_1135883(41265500, +), ADediting_1135884(41265529, +), ADediting_1135885(41265536, +), ADediting_1135886(41265539, +), ADediting_1135887(41265558, +), ADediting_1135888(41265566, +), ADediting_1135889(41266196, +), ADediting_1135890(41266643, +), ADediting_1135891(41266644, +), ADediting_1135892(41266660, +), ADediting_1135893(41266685, +), ADediting_1135894(41266688, +), ADediting_1135895(41266753, +), ADediting_1135896(41266756, +), ADediting_1135897(41266759, +), ADediting_1135898(41266761, +), ADediting_1135899(41266762, +), ADediting_1135900(41266772, +), ADediting_1135901(41266781, +), ADediting_1135902(41266785, +), ADediting_1135903(41266786, +), ADediting_1135904(41266792, +), ADediting_1135905(41266793, +), ADediting_1135906(41266800, +), ADediting_1135907(41266803, +), ADediting_1135908(41266816, +), ADediting_1135909(41266829, +), ADediting_1135910(41267263, +), ADediting_1135911(41267324, +), ADediting_1135912(41267428, +), ADediting_1135913(41267431, +), ADediting_1135914(41267445, +), ADediting_1135915(41267520, +), ADediting_1135916(41267522, +), ADediting_1135917(41267771, +), ADediting_1577701(41259367, +), ADediting_1577702(41262711, +), ADediting_1577703(41266144, +), ADediting_1577704(41267361, +), ADediting_1652073(41262184, +), |
Top |
RNA editing positional annotations for UCHL1 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_1135819 | chr4_41262190_+ | intronic |
| ADediting_1135820 | chr4_41262198_+ | intronic |
| ADediting_1135821 | chr4_41262207_+ | intronic |
| ADediting_1135822 | chr4_41262212_+ | intronic |
| ADediting_1135823 | chr4_41262213_+ | intronic |
| ADediting_1135824 | chr4_41262216_+ | intronic |
| ADediting_1135825 | chr4_41262242_+ | intronic |
| ADediting_1135826 | chr4_41262247_+ | intronic |
| ADediting_1135827 | chr4_41262252_+ | intronic |
| ADediting_1135828 | chr4_41262261_+ | intronic |
| ADediting_1135829 | chr4_41262263_+ | intronic |
| ADediting_1135830 | chr4_41262266_+ | intronic |
| ADediting_1135831 | chr4_41262276_+ | intronic |
| ADediting_1135832 | chr4_41262278_+ | intronic |
| ADediting_1135833 | chr4_41262280_+ | intronic |
| ADediting_1135834 | chr4_41262284_+ | intronic |
| ADediting_1135835 | chr4_41262285_+ | intronic |
| ADediting_1135836 | chr4_41262286_+ | intronic |
| ADediting_1135837 | chr4_41262325_+ | intronic |
| ADediting_1135838 | chr4_41262331_+ | intronic |
| ADediting_1135839 | chr4_41262335_+ | intronic |
| ADediting_1135840 | chr4_41262391_+ | intronic |
| ADediting_1135841 | chr4_41262652_+ | intronic |
| ADediting_1135842 | chr4_41262671_+ | intronic |
| ADediting_1135843 | chr4_41262679_+ | intronic |
| ADediting_1135844 | chr4_41262736_+ | intronic |
| ADediting_1135845 | chr4_41262791_+ | intronic |
| ADediting_1135846 | chr4_41262803_+ | intronic |
| ADediting_1135847 | chr4_41262806_+ | intronic |
| ADediting_1135848 | chr4_41262815_+ | intronic |
| ADediting_1135849 | chr4_41262842_+ | intronic |
| ADediting_1135850 | chr4_41262843_+ | intronic |
| ADediting_1135851 | chr4_41262860_+ | intronic |
| ADediting_1135852 | chr4_41262870_+ | intronic |
| ADediting_1135853 | chr4_41262876_+ | intronic |
| ADediting_1135854 | chr4_41263078_+ | intronic |
| ADediting_1135855 | chr4_41265301_+ | intronic |
| ADediting_1135856 | chr4_41265321_+ | intronic |
| ADediting_1135857 | chr4_41265324_+ | intronic |
| ADediting_1135858 | chr4_41265329_+ | intronic |
| ADediting_1135859 | chr4_41265363_+ | intronic |
| ADediting_1135860 | chr4_41265368_+ | intronic |
| ADediting_1135861 | chr4_41265376_+ | intronic |
| ADediting_1135862 | chr4_41265377_+ | intronic |
| ADediting_1135863 | chr4_41265392_+ | intronic |
| ADediting_1135864 | chr4_41265393_+ | intronic |
| ADediting_1135865 | chr4_41265394_+ | intronic |
| ADediting_1135866 | chr4_41265413_+ | intronic |
| ADediting_1135867 | chr4_41265416_+ | intronic |
| ADediting_1135868 | chr4_41265417_+ | intronic |
| ADediting_1135869 | chr4_41265418_+ | intronic |
| ADediting_1135870 | chr4_41265419_+ | intronic |
| ADediting_1135871 | chr4_41265422_+ | intronic |
| ADediting_1135872 | chr4_41265425_+ | intronic |
| ADediting_1135873 | chr4_41265426_+ | intronic |
| ADediting_1135874 | chr4_41265427_+ | intronic |
| ADediting_1135875 | chr4_41265428_+ | intronic |
| ADediting_1135876 | chr4_41265431_+ | intronic |
| ADediting_1135877 | chr4_41265435_+ | intronic |
| ADediting_1135878 | chr4_41265449_+ | intronic |
| ADediting_1135879 | chr4_41265463_+ | intronic |
| ADediting_1135880 | chr4_41265480_+ | intronic |
| ADediting_1135881 | chr4_41265487_+ | intronic |
| ADediting_1135882 | chr4_41265490_+ | intronic |
| ADediting_1135883 | chr4_41265500_+ | intronic |
| ADediting_1135884 | chr4_41265529_+ | intronic |
| ADediting_1135885 | chr4_41265536_+ | intronic |
| ADediting_1135886 | chr4_41265539_+ | intronic |
| ADediting_1135887 | chr4_41265558_+ | intronic |
| ADediting_1135888 | chr4_41265566_+ | intronic |
| ADediting_1135889 | chr4_41266196_+ | intronic |
| ADediting_1135890 | chr4_41266643_+ | intronic |
| ADediting_1135891 | chr4_41266644_+ | intronic |
| ADediting_1135892 | chr4_41266660_+ | intronic |
| ADediting_1135893 | chr4_41266685_+ | intronic |
| ADediting_1135894 | chr4_41266688_+ | intronic |
| ADediting_1135895 | chr4_41266753_+ | intronic |
| ADediting_1135896 | chr4_41266756_+ | intronic |
| ADediting_1135897 | chr4_41266759_+ | intronic |
| ADediting_1135898 | chr4_41266761_+ | intronic |
| ADediting_1135899 | chr4_41266762_+ | intronic |
| ADediting_1135900 | chr4_41266772_+ | intronic |
| ADediting_1135901 | chr4_41266781_+ | intronic |
| ADediting_1135902 | chr4_41266785_+ | intronic |
| ADediting_1135903 | chr4_41266786_+ | intronic |
| ADediting_1135904 | chr4_41266792_+ | intronic |
| ADediting_1135905 | chr4_41266793_+ | intronic |
| ADediting_1135906 | chr4_41266800_+ | intronic |
| ADediting_1135907 | chr4_41266803_+ | intronic |
| ADediting_1135908 | chr4_41266816_+ | intronic |
| ADediting_1135909 | chr4_41266829_+ | intronic |
| ADediting_1135910 | chr4_41267263_+ | intronic |
| ADediting_1135911 | chr4_41267324_+ | intronic |
| ADediting_1135912 | chr4_41267428_+ | intronic |
| ADediting_1135913 | chr4_41267431_+ | intronic |
| ADediting_1135914 | chr4_41267445_+ | intronic |
| ADediting_1135915 | chr4_41267520_+ | intronic |
| ADediting_1135916 | chr4_41267522_+ | intronic |
| ADediting_1135917 | chr4_41267771_+ | intronic |
| ADediting_1577701 | chr4_41259367_+ | intronic |
| ADediting_1577702 | chr4_41262711_+ | intronic |
| ADediting_1577703 | chr4_41266144_+ | intronic |
| ADediting_1577704 | chr4_41267361_+ | intronic |
| ADediting_1652073 | chr4_41262184_+ | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_1135819 | chr4_41262190_+ | SINE | Alu | Name=AluJb |
| ADediting_1135820 | chr4_41262198_+ | SINE | Alu | Name=AluJb |
| ADediting_1135821 | chr4_41262207_+ | SINE | Alu | Name=AluJb |
| ADediting_1135822 | chr4_41262212_+ | SINE | Alu | Name=AluJb |
| ADediting_1135823 | chr4_41262213_+ | SINE | Alu | Name=AluJb |
| ADediting_1135824 | chr4_41262216_+ | SINE | Alu | Name=AluJb |
| ADediting_1135825 | chr4_41262242_+ | SINE | Alu | Name=AluJb |
| ADediting_1135826 | chr4_41262247_+ | SINE | Alu | Name=AluJb |
| ADediting_1135827 | chr4_41262252_+ | SINE | Alu | Name=AluJb |
| ADediting_1135828 | chr4_41262261_+ | SINE | Alu | Name=AluJb |
| ADediting_1135829 | chr4_41262263_+ | SINE | Alu | Name=AluJb |
| ADediting_1135830 | chr4_41262266_+ | SINE | Alu | Name=AluJb |
| ADediting_1135831 | chr4_41262276_+ | SINE | Alu | Name=AluJb |
| ADediting_1135832 | chr4_41262278_+ | SINE | Alu | Name=AluJb |
| ADediting_1135833 | chr4_41262280_+ | SINE | Alu | Name=AluJb |
| ADediting_1135834 | chr4_41262284_+ | SINE | Alu | Name=AluJb |
| ADediting_1135835 | chr4_41262285_+ | SINE | Alu | Name=AluJb |
| ADediting_1135836 | chr4_41262286_+ | SINE | Alu | Name=AluJb |
| ADediting_1135837 | chr4_41262325_+ | SINE | Alu | Name=AluJb |
| ADediting_1135838 | chr4_41262331_+ | SINE | Alu | Name=AluJb |
| ADediting_1135839 | chr4_41262335_+ | SINE | Alu | Name=AluJb |
| ADediting_1135840 | chr4_41262391_+ | SINE | Alu | Name=AluJb |
| ADediting_1135842 | chr4_41262671_+ | SINE | Alu | Name=AluSz |
| ADediting_1135843 | chr4_41262679_+ | SINE | Alu | Name=AluSz |
| ADediting_1135844 | chr4_41262736_+ | SINE | Alu | Name=AluSz |
| ADediting_1135845 | chr4_41262791_+ | SINE | Alu | Name=AluSz |
| ADediting_1135846 | chr4_41262803_+ | SINE | Alu | Name=AluSz |
| ADediting_1135847 | chr4_41262806_+ | SINE | Alu | Name=AluSz |
| ADediting_1135848 | chr4_41262815_+ | SINE | Alu | Name=AluSz |
| ADediting_1135849 | chr4_41262842_+ | SINE | Alu | Name=AluSz |
| ADediting_1135850 | chr4_41262843_+ | SINE | Alu | Name=AluSz |
| ADediting_1135851 | chr4_41262860_+ | SINE | Alu | Name=AluSz |
| ADediting_1135852 | chr4_41262870_+ | SINE | Alu | Name=AluSz |
| ADediting_1135853 | chr4_41262876_+ | SINE | Alu | Name=AluSz |
| ADediting_1135854 | chr4_41263078_+ | SINE | MIR | Name=MIR |
| ADediting_1135855 | chr4_41265301_+ | SINE | Alu | Name=AluSz |
| ADediting_1135856 | chr4_41265321_+ | SINE | Alu | Name=AluSz |
| ADediting_1135857 | chr4_41265324_+ | SINE | Alu | Name=AluSz |
| ADediting_1135858 | chr4_41265329_+ | SINE | Alu | Name=AluSz |
| ADediting_1135859 | chr4_41265363_+ | SINE | Alu | Name=AluSz |
| ADediting_1135860 | chr4_41265368_+ | SINE | Alu | Name=AluSz |
| ADediting_1135861 | chr4_41265376_+ | SINE | Alu | Name=AluSz |
| ADediting_1135862 | chr4_41265377_+ | SINE | Alu | Name=AluSz |
| ADediting_1135863 | chr4_41265392_+ | SINE | Alu | Name=AluSz |
| ADediting_1135864 | chr4_41265393_+ | SINE | Alu | Name=AluSz |
| ADediting_1135865 | chr4_41265394_+ | SINE | Alu | Name=AluSz |
| ADediting_1135866 | chr4_41265413_+ | SINE | Alu | Name=AluSz |
| ADediting_1135867 | chr4_41265416_+ | SINE | Alu | Name=AluSz |
| ADediting_1135868 | chr4_41265417_+ | SINE | Alu | Name=AluSz |
| ADediting_1135869 | chr4_41265418_+ | SINE | Alu | Name=AluSz |
| ADediting_1135870 | chr4_41265419_+ | SINE | Alu | Name=AluSz |
| ADediting_1135871 | chr4_41265422_+ | SINE | Alu | Name=AluSz |
| ADediting_1135872 | chr4_41265425_+ | SINE | Alu | Name=AluSz |
| ADediting_1135873 | chr4_41265426_+ | SINE | Alu | Name=AluSz |
| ADediting_1135874 | chr4_41265427_+ | SINE | Alu | Name=AluSz |
| ADediting_1135875 | chr4_41265428_+ | SINE | Alu | Name=AluSz |
| ADediting_1135876 | chr4_41265431_+ | SINE | Alu | Name=AluSz |
| ADediting_1135877 | chr4_41265435_+ | SINE | Alu | Name=AluSz |
| ADediting_1135878 | chr4_41265449_+ | SINE | Alu | Name=AluSz |
| ADediting_1135879 | chr4_41265463_+ | SINE | Alu | Name=AluSz |
| ADediting_1135880 | chr4_41265480_+ | SINE | Alu | Name=AluSz |
| ADediting_1135881 | chr4_41265487_+ | SINE | Alu | Name=AluSz |
| ADediting_1135882 | chr4_41265490_+ | SINE | Alu | Name=AluSz |
| ADediting_1135883 | chr4_41265500_+ | SINE | Alu | Name=AluSz |
| ADediting_1135884 | chr4_41265529_+ | SINE | Alu | Name=AluSz |
| ADediting_1135885 | chr4_41265536_+ | SINE | Alu | Name=AluSz |
| ADediting_1135886 | chr4_41265539_+ | SINE | Alu | Name=AluSz |
| ADediting_1135887 | chr4_41265558_+ | SINE | Alu | Name=AluSz |
| ADediting_1135888 | chr4_41265566_+ | SINE | Alu | Name=AluSz |
| ADediting_1135889 | chr4_41266196_+ | SINE | Alu | Name=AluJo |
| ADediting_1135890 | chr4_41266643_+ | SINE | Alu | Name=AluJr4 |
| ADediting_1135891 | chr4_41266644_+ | SINE | Alu | Name=AluJr4 |
| ADediting_1135892 | chr4_41266660_+ | SINE | Alu | Name=AluJr4 |
| ADediting_1135893 | chr4_41266685_+ | SINE | Alu | Name=AluJr4 |
| ADediting_1135894 | chr4_41266688_+ | SINE | Alu | Name=AluJr4 |
| ADediting_1135895 | chr4_41266753_+ | SINE | Alu | Name=AluJr4 |
| ADediting_1135896 | chr4_41266756_+ | SINE | Alu | Name=AluJr4 |
| ADediting_1135897 | chr4_41266759_+ | SINE | Alu | Name=AluJr4 |
| ADediting_1135898 | chr4_41266761_+ | SINE | Alu | Name=AluJr4 |
| ADediting_1135899 | chr4_41266762_+ | SINE | Alu | Name=AluJr4 |
| ADediting_1135900 | chr4_41266772_+ | SINE | Alu | Name=AluJr4 |
| ADediting_1135901 | chr4_41266781_+ | SINE | Alu | Name=AluJr4 |
| ADediting_1135902 | chr4_41266785_+ | SINE | Alu | Name=AluJr4 |
| ADediting_1135903 | chr4_41266786_+ | SINE | Alu | Name=AluJr4 |
| ADediting_1135904 | chr4_41266792_+ | SINE | Alu | Name=AluJr4 |
| ADediting_1135905 | chr4_41266793_+ | SINE | Alu | Name=AluJr4 |
| ADediting_1135906 | chr4_41266800_+ | SINE | Alu | Name=AluJr4 |
| ADediting_1135907 | chr4_41266803_+ | SINE | Alu | Name=AluJr4 |
| ADediting_1135908 | chr4_41266816_+ | SINE | Alu | Name=AluJr4 |
| ADediting_1135909 | chr4_41266829_+ | SINE | Alu | Name=AluJr4 |
| ADediting_1135910 | chr4_41267263_+ | SINE | Alu | Name=AluY |
| ADediting_1135911 | chr4_41267324_+ | SINE | Alu | Name=AluY |
| ADediting_1135912 | chr4_41267428_+ | SINE | Alu | Name=AluY |
| ADediting_1135913 | chr4_41267431_+ | SINE | Alu | Name=AluY |
| ADediting_1135914 | chr4_41267445_+ | SINE | Alu | Name=AluY |
| ADediting_1135915 | chr4_41267520_+ | SINE | Alu | Name=AluY |
| ADediting_1135916 | chr4_41267522_+ | SINE | Alu | Name=AluY |
| ADediting_1577702 | chr4_41262711_+ | SINE | Alu | Name=AluSz |
| ADediting_1577703 | chr4_41266144_+ | SINE | Alu | Name=AluJo |
| ADediting_1577704 | chr4_41267361_+ | SINE | Alu | Name=AluY |
| ADediting_1652073 | chr4_41262184_+ | SINE | Alu | Name=AluJb |
Top |
RNA A-to-I editing events in the alternative splicing sites for UCHL1 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
Top |
Differntial gene expression between RNA A-to-I edited versus non-edited samples for UCHL1 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
Top |
Protein coding region RNA A-to-I editings for UCHL1 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
Top |
The effects of the RNA editing to the miRNA binding sites for UCHL1 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000154277.13 | ENST00000284440.9 | UCHL1-201 | hsa-miR-5688 | chr4 | 41268387 | 41268393 | 7mer-m8 | 41268373 | 41268394 | 156 | -11.71 |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000154277.13 | ENST00000284440.9 | UCHL1-201 | hsa-miR-4477b | chr4 | 41268392 | 41268399 | 8mer-1a | 41268380 | 41268399 | 153 | -15.58 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1337757 | chr7_5495852_- | ENSG00000154277.13 | ENST00000284440.9 | UCHL1-201 | hsa-miR-589-3p | chr4 | 41268184 | 41268190 | 7mer-m8 | 41268167 | 41268191 | 153 | -12.25 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000154277.13 | ENST00000503431.5 | UCHL1-204 | hsa-miR-589-3p | chr4 | 41268184 | 41268190 | 7mer-m8 | 41268167 | 41268191 | 153 | -12.25 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000154277.13 | ENST00000508768.5 | UCHL1-207 | hsa-miR-589-3p | chr4 | 41268184 | 41268190 | 7mer-m8 | 41268167 | 41268191 | 153 | -12.25 |
| ADediting_1391023 | chr8_140732605_- | ENSG00000154277.13 | ENST00000284440.9 | UCHL1-201 | hsa-miR-151a-3p | chr4 | 41268141 | 41268148 | 8mer-1a | 41268128 | 41268148 | 142 | -11.24 |
| ADediting_1391023 | chr8_140732605_- | ENSG00000154277.13 | ENST00000503431.5 | UCHL1-204 | hsa-miR-151a-3p | chr4 | 41268141 | 41268148 | 8mer-1a | 41268128 | 41268148 | 142 | -11.24 |
| ADediting_1391023 | chr8_140732605_- | ENSG00000154277.13 | ENST00000508768.5 | UCHL1-207 | hsa-miR-151a-3p | chr4 | 41268141 | 41268148 | 8mer-1a | 41268128 | 41268148 | 142 | -11.24 |
| ADediting_1535953 | chr14_101045971_+ | ENSG00000154277.13 | ENST00000284440.9 | UCHL1-201 | hsa-miR-381-3p | chr4 | 41268309 | 41268315 | 7mer-m8 | 41268296 | 41268316 | 152 | -12.44 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000154277.13 | ENST00000284440.9 | UCHL1-201 | hsa-miR-381-3p | chr4 | 41268309 | 41268315 | 7mer-m8 | 41268296 | 41268316 | 152 | -12.44 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000154277.13 | ENST00000284440.9 | UCHL1-201 | hsa-miR-641 | chr4 | 41268305 | 41268311 | 7mer-m8 | 41268289 | 41268312 | 149 | -13.22 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000154277.13 | ENST00000284440.9 | UCHL1-201 | hsa-miR-641 | chr4 | 41268305 | 41268311 | 7mer-m8 | 41268289 | 41268312 | 149 | -13.22 |
| Differentially expressed gene-miRNA network |
Top |
The effects of the RNA editing to the stability of the RNA structures for UCHL1 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
Top |
Relation with ADAR for UCHL1 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | ADediting_1135822 | chr4_41262212_+ | 3.1090372042574e-11 | 0.365544041387061 | 4.74109129925116e-09 | 0.324848123419522 | 0.812857897476472 | 0.0134998962233753 |
| TCX | ADediting_1135822 | chr4_41262212_+ | 1.72016761561198e-08 | 0.44029049514039 | 6.80055131838389e-09 | 0.451278947577902 | 0.334577792134696 | -0.0793259033226731 |
| STG | ADediting_1135822 | chr4_41262212_+ | 0.00504565552068848 | 0.303256751310762 | 0.00651216330118082 | 0.294658508484303 | 0.497844582538018 | -0.0749826281215191 |
| CER | ADediting_1135823 | chr4_41262213_+ | 4.02764000330762e-08 | 0.429862630080167 | 1.10084975281407e-12 | 0.539110415442145 | 2.22376860284677e-05 | 0.3388236047652 |
| TCX | ADediting_1135823 | chr4_41262213_+ | 3.51228875570701e-11 | 0.507190773739302 | 1.13037363591978e-09 | 0.471483876305708 | 0.682255695436998 | -0.03369871498915 |
| STG | ADediting_1135823 | chr4_41262213_+ | 0.0034733170079929 | 0.315405682327855 | 0.00157271858526904 | 0.339659304310363 | 0.483120721850084 | -0.0775640655895714 |
| CER | ADediting_1135825 | chr4_41262242_+ | 0.00866049012704715 | 0.213650974745015 | 8.82374065342674e-05 | 0.314600336473647 | 0.00201435943892791 | 0.250212743584455 |
| CER | ADediting_1135829 | chr4_41262263_+ | 2.28718671934996e-06 | 0.374864975261696 | 4.01233835835973e-10 | 0.48257465797998 | 0.149228141031238 | 0.118336044235011 |
| CER | ADediting_1135830 | chr4_41262266_+ | 9.10614821062814e-10 | 0.473831678262345 | 8.88310293797754e-14 | 0.560374259797429 | 0.0293015101838266 | 0.178013144605972 |
| TCX | ADediting_1135830 | chr4_41262266_+ | 2.84580649957042e-07 | 0.404471531982612 | 1.24313021829273e-07 | 0.415483460650241 | 0.715566138879254 | -0.0299966298704002 |
| CER | ADediting_1135831 | chr4_41262276_+ | 0.000391676392771115 | 0.285826894620632 | 1.2903584549847e-07 | 0.414996078995319 | 0.0139770404392995 | 0.200320137542431 |
| CER | ADediting_1135832 | chr4_41262278_+ | 5.04443828956974e-06 | 0.362821678315411 | 3.69789202648274e-09 | 0.458287099765692 | 0.0132204539089216 | 0.201910378063569 |
| TCX | ADediting_1135832 | chr4_41262278_+ | 2.12864424902665e-09 | 0.464506230356608 | 3.19703039373945e-10 | 0.484954882243923 | 0.897535767254727 | -0.0106028288060127 |
| STG | ADediting_1135832 | chr4_41262278_+ | 1.78061586265447e-05 | 0.449639647743559 | 2.87449541504646e-06 | 0.485376993994212 | 0.688620628193183 | 0.0443662116644796 |
| CER | ADediting_1135833 | chr4_41262280_+ | 4.18336848118235e-06 | 0.365715673710376 | 3.23655828469365e-09 | 0.459799070946934 | 0.000222539046363826 | 0.297096431712766 |
| TCX | ADediting_1135833 | chr4_41262280_+ | 2.51501238528059e-07 | 0.406139795004296 | 2.73045429437672e-09 | 0.461717864051128 | 0.53918836153991 | -0.0505268634909574 |
| IFG | ADediting_1135833 | chr4_41262280_+ | 0.941470040704675 | 0.015475949715298 | 0.636173149917295 | 0.099468409215367 | 0.015714922787388 | 0.477777996229828 |
| STG | ADediting_1135833 | chr4_41262280_+ | 0.00673800512016408 | 0.29349024648086 | 0.000429265222355688 | 0.375671018915408 | 0.751344412243248 | -0.0350881477145571 |
| CER | ADediting_1135835 | chr4_41262285_+ | 1.12507887767631e-05 | 0.350088993250062 | 3.00915606094443e-07 | 0.403715026874866 | 0.970846147367906 | 0.00300922265629489 |
| TCX | ADediting_1135835 | chr4_41262285_+ | 2.04535552722267e-06 | 0.376528160760211 | 1.16187361774961e-06 | 0.38480713538555 | 0.231043271508632 | -0.098375374260129 |
| CER | ADediting_1135836 | chr4_41262286_+ | 5.97081863174856e-06 | 0.36019053350197 | 3.83832052746913e-11 | 0.506327243821704 | 0.112063916179241 | 0.130276312208608 |
| TCX | ADediting_1135836 | chr4_41262286_+ | 1.5553569656662e-06 | 0.380565686820922 | 7.20877110473159e-08 | 0.422519448039384 | 0.469930380332445 | -0.0594444956895835 |
| CER | ADediting_1135837 | chr4_41262325_+ | 0.0135719658825418 | 0.201161912943376 | 0.000132520652433154 | 0.307039510555435 | 0.197161151115264 | 0.105891589121971 |
| CER | ADediting_1135839 | chr4_41262335_+ | 1.26190376648281e-06 | 0.383612181769547 | 1.3177834170029e-11 | 0.516569703893766 | 0.0571633339784764 | 0.155656703572531 |
| CER | ADediting_1135841 | chr4_41262652_+ | 0.000998922152922415 | 0.266060942344349 | 1.86553865959798e-06 | 0.377890851068445 | 0.00203768025504 | 0.249944314513841 |
| TCX | ADediting_1135841 | chr4_41262652_+ | 8.94673303062721e-09 | 0.44807145472479 | 1.39563637480949e-08 | 0.442800279473705 | 0.169798938908405 | -0.112678032647552 |
| CER | ADediting_1135842 | chr4_41262671_+ | 0.0162226147548524 | 0.19600691979908 | 2.14244008107986e-05 | 0.33945098563665 | 0.00122724642017982 | 0.261509388701334 |
| CER | ADediting_1135843 | chr4_41262679_+ | 0.000766041202330995 | 0.271815773070719 | 5.30638328136859e-08 | 0.426406155553842 | 0.000243442487930137 | 0.295337452404042 |
| TCX | ADediting_1135843 | chr4_41262679_+ | 2.23002041780694e-11 | 0.511572325887175 | 2.25311466531061e-11 | 0.511473637572629 | 0.220262714231665 | -0.100676280120145 |
| CER | ADediting_1135844 | chr4_41262736_+ | 1.11118854045926e-05 | 0.350290427137689 | 2.64351882797219e-10 | 0.486933031125053 | 0.0203206441011554 | 0.189324764729815 |
| TCX | ADediting_1135844 | chr4_41262736_+ | 1.37184758528454e-08 | 0.443005759765719 | 5.3966081219524e-09 | 0.453957491885722 | 0.588999773541017 | -0.04446430867863 |
| FP | ADediting_1135844 | chr4_41262736_+ | 0.00887407699012647 | 0.195621950645997 | 3.47343075463049e-05 | 0.305025757769207 | 0.274213036672325 | -0.0823957394783956 |
| STG | ADediting_1135844 | chr4_41262736_+ | 0.00363298245857642 | 0.313969477482459 | 0.00231433807696115 | 0.328076500352939 | 0.0772308813541177 | -0.193865057263964 |
| CER | ADediting_1135846 | chr4_41262803_+ | 0.00424979841635008 | 0.232179869687377 | 2.91674330877564e-05 | 0.334214499352532 | 0.922350837522548 | -0.00802564095729364 |
| DLPFC | ADediting_1135847 | chr4_41262806_+ | 8.45311087447903e-10 | 0.339478829331049 | 1.30784573509406e-08 | 0.315860901131955 | 0.899822126414711 | 0.00717875543009249 |
| CER | ADediting_1135847 | chr4_41262806_+ | 6.17049709477243e-05 | 0.321086172213568 | 2.61533204912776e-09 | 0.462202077563601 | 0.00319442533389106 | 0.239229957187405 |
| TCX | ADediting_1135847 | chr4_41262806_+ | 3.63837034617988e-07 | 0.401127304659956 | 4.95747608947257e-08 | 0.427262355013141 | 0.70691668311505 | -0.0309518635514396 |
| CER | ADediting_1135849 | chr4_41262842_+ | 0.0102570631715303 | 0.209025968364 | 5.38916612620841e-05 | 0.323503190371788 | 0.201621359691751 | 0.104851681997131 |
| DLPFC | ADediting_1135850 | chr4_41262843_+ | 3.73493383580663e-11 | 0.364157144629763 | 1.78127225421182e-09 | 0.333248642426198 | 0.244285670566125 | 0.0663252474859558 |
| CER | ADediting_1135850 | chr4_41262843_+ | 0.0125829747394545 | 0.203313343976804 | 3.23429777605862e-06 | 0.369648845868174 | 0.00953491529909857 | 0.211032870129006 |
| TCX | ADediting_1135850 | chr4_41262843_+ | 6.44385311606229e-06 | 0.358992993280459 | 0.000239873371898343 | 0.295627598833649 | 0.550191017554869 | -0.0491653155723996 |
| STG | ADediting_1135850 | chr4_41262843_+ | 2.76134777125455e-05 | 0.440408522622523 | 0.00862675302754008 | 0.284879150156367 | 0.602239658873412 | 0.0576825949314507 |
| DLPFC | ADediting_1135851 | chr4_41262860_+ | 1.95988788339131e-11 | 0.369003960404216 | 4.99236721459874e-08 | 0.30352042930091 | 0.01405839326401 | 0.139359954257568 |
| CER | ADediting_1135851 | chr4_41262860_+ | 7.86901139744168e-07 | 0.390382766475275 | 7.88936593353317e-12 | 0.521366129816409 | 0.0140367447360416 | 0.200197875436697 |
| TCX | ADediting_1135851 | chr4_41262860_+ | 1.26322869257311e-11 | 0.516967844692933 | 1.63474438389233e-10 | 0.491878444679018 | 0.891753759347424 | -0.0112047114575708 |
| STG | ADediting_1135851 | chr4_41262860_+ | 7.11438756773668e-05 | 0.419537587446195 | 0.000225952961359441 | 0.392041725328754 | 0.980758439910873 | 0.00267152138845565 |
| DLPFC | ADediting_1135853 | chr4_41262876_+ | 4.92504105740018e-09 | 0.324516253660327 | 3.6024872635598e-07 | 0.284193842323133 | 0.549924750441947 | -0.0340847239562323 |
| CER | ADediting_1135853 | chr4_41262876_+ | 6.20607362541817e-06 | 0.359584151303032 | 7.40362735458938e-11 | 0.499860304067473 | 0.00545821064719503 | 0.225828052650193 |
| TCX | ADediting_1135853 | chr4_41262876_+ | 7.3357212830966e-13 | 0.542642435116877 | 1.52948726077556e-11 | 0.515162659849935 | 0.970244214418208 | -0.00307138163336156 |
| FP | ADediting_1135853 | chr4_41262876_+ | 1.73531843308698e-07 | 0.379594357083201 | 0.000164106629702856 | 0.278817160212018 | 0.901723481381057 | 0.00932101952810705 |
| STG | ADediting_1135853 | chr4_41262876_+ | 0.00303626795157977 | 0.31966232608818 | 0.00208963932089812 | 0.331181912369363 | 0.407070957310898 | -0.0916403352372442 |
| DLPFC | ADediting_1135855 | chr4_41265301_+ | 7.13158160551327e-08 | 0.300136607849879 | 5.92006785125536e-11 | 0.36064452224432 | 0.133574297163977 | 0.0853923385927415 |
| TCX | ADediting_1135855 | chr4_41265301_+ | 1.29019148025012e-05 | 0.347859404877794 | 2.78250859439731e-05 | 0.335020312389104 | 0.0465579830469326 | -0.162783416012641 |
| DLPFC | ADediting_1135856 | chr4_41265321_+ | 1.17101355273299e-07 | 0.295357775987792 | 4.01757155648668e-14 | 0.411859007331485 | 0.0312386687371917 | 0.122374264613708 |
| TCX | ADediting_1135856 | chr4_41265321_+ | 0.000849042451976438 | 0.269600350720585 | 5.84303530405902e-07 | 0.39457409228219 | 0.0495037587114479 | -0.160678987503195 |
| DLPFC | ADediting_1135859 | chr4_41265363_+ | 1.20973221101806e-05 | 0.245702593122375 | 1.27036260793977e-10 | 0.354725567797357 | 0.0467885352580682 | 0.11301723069665 |
| CER | ADediting_1135859 | chr4_41265363_+ | 0.00594471469721581 | 0.223622220003091 | 8.17064851520305e-05 | 0.316007356286344 | 0.0240208186127249 | 0.184227635941561 |
| TCX | ADediting_1135859 | chr4_41265363_+ | 3.24654495499751e-09 | 0.459764196711849 | 4.15529230569069e-10 | 0.48220618900203 | 0.376514732169301 | -0.0727184202309663 |
| DLPFC | ADediting_1135860 | chr4_41265368_+ | 7.62636085980877e-05 | 0.222747791625775 | 2.05870100666141e-09 | 0.332022470323178 | 0.0447118003708638 | 0.114098495284544 |
| CER | ADediting_1135860 | chr4_41265368_+ | 3.21217963787096e-06 | 0.369753035469156 | 2.87335021786387e-08 | 0.434044011674142 | 0.0147905613836999 | 0.198692043627775 |
| TCX | ADediting_1135860 | chr4_41265368_+ | 1.91814107846851e-06 | 0.377479729729958 | 1.19180813006665e-07 | 0.416033615206741 | 0.895404959450404 | -0.0108245699735741 |
| CER | ADediting_1135862 | chr4_41265377_+ | 0.00023371041709376 | 0.296138179379662 | 6.53592476591811e-05 | 0.320052803908609 | 0.0767894958591478 | 0.144937865474559 |
| DLPFC | ADediting_1135866 | chr4_41265413_+ | 2.1932312646095e-07 | 0.289183187617635 | 3.99936214640299e-10 | 0.345598050949194 | 0.0358889402313377 | 0.119225085587538 |
| CER | ADediting_1135866 | chr4_41265413_+ | 4.26164475561838e-05 | 0.327645966468136 | 1.14099730238671e-06 | 0.385068843685953 | 0.197702311431473 | 0.105764514857568 |
| TCX | ADediting_1135866 | chr4_41265413_+ | 1.0416807511258e-10 | 0.496444791461083 | 5.80602458749989e-10 | 0.478663162418058 | 0.839859240722604 | -0.0166372712636076 |
| DLPFC | ADediting_1135867 | chr4_41265416_+ | 8.03517781247456e-06 | 0.250509667794023 | 2.920170287337e-09 | 0.329038709974609 | 0.00270202335188213 | 0.169821125272367 |
| CER | ADediting_1135867 | chr4_41265416_+ | 4.56774428848635e-05 | 0.32642799904441 | 4.81934283114254e-06 | 0.363530089869888 | 0.173156297643813 | 0.111803859437721 |
| TCX | ADediting_1135867 | chr4_41265416_+ | 3.38056047512058e-07 | 0.402131518621049 | 1.07085414844292e-07 | 0.417425644784963 | 0.343577693238815 | -0.0778659097530471 |
| DLPFC | ADediting_1135868 | chr4_41265417_+ | 2.31438987262162e-06 | 0.264568693940579 | 3.47333790996833e-09 | 0.327545974572305 | 0.00509807239992743 | 0.158704833214339 |
| CER | ADediting_1135868 | chr4_41265417_+ | 1.26997855394694e-05 | 0.348117369374116 | 1.82629458525436e-08 | 0.439568063531693 | 0.0880361331210424 | 0.13976672194301 |
| TCX | ADediting_1135868 | chr4_41265417_+ | 1.29635687815168e-06 | 0.383221417924906 | 1.59241488183167e-07 | 0.412232293561918 | 0.284119346223332 | -0.088022348999612 |
| DLPFC | ADediting_1135869 | chr4_41265418_+ | 3.51970582879645e-08 | 0.306795687631533 | 1.43635563435537e-11 | 0.371311223506462 | 0.00491456979355337 | 0.159365483223892 |
| CER | ADediting_1135869 | chr4_41265418_+ | 5.20916893947946e-07 | 0.396175587367359 | 6.11411038158321e-08 | 0.424614830989956 | 0.0177621604145739 | 0.193341154679202 |
| TCX | ADediting_1135869 | chr4_41265418_+ | 5.94327125560356e-07 | 0.394336152164731 | 2.72712391242798e-07 | 0.405047673813049 | 0.192436949939391 | -0.107011807936029 |
| DLPFC | ADediting_1135870 | chr4_41265419_+ | 3.96597647561888e-08 | 0.305681618808862 | 2.45477700286695e-13 | 0.399956460842395 | 0.00248132232339726 | 0.17126356926606 |
| CER | ADediting_1135870 | chr4_41265419_+ | 4.12480493391134e-08 | 0.429565323073769 | 4.74985384596976e-09 | 0.45542639924218 | 0.0381996399277564 | 0.169427563830357 |
| TCX | ADediting_1135870 | chr4_41265419_+ | 3.52027666228017e-08 | 0.431536516479791 | 5.18382715183965e-08 | 0.426700579987145 | 0.522679883607989 | -0.052595933355559 |
| CER | ADediting_1135871 | chr4_41265422_+ | 3.55599725747598e-10 | 0.483842098729695 | 6.3062668786705e-15 | 0.581199845613169 | 0.00122842341456196 | 0.261488006234981 |
| DLPFC | ADediting_1135874 | chr4_41265427_+ | 9.98057580867559e-07 | 0.273632764542224 | 5.02446978327254e-09 | 0.324341834778271 | 0.266596659910763 | 0.0632892226540804 |
| CER | ADediting_1135874 | chr4_41265427_+ | 2.72789854329876e-05 | 0.335358651446955 | 0.000240673593562932 | 0.295562198925393 | 0.0141613390460043 | 0.199944188275789 |
| DLPFC | ADediting_1135876 | chr4_41265431_+ | 8.79752780930437e-06 | 0.249453095020613 | 4.45403679227805e-10 | 0.344725789104114 | 0.0209380542546641 | 0.1311110846639 |
| CER | ADediting_1135876 | chr4_41265431_+ | 6.37759809885756e-10 | 0.477661348796139 | 1.39194019547073e-10 | 0.493515412644622 | 0.0192110282791277 | 0.191009598328508 |
| TCX | ADediting_1135876 | chr4_41265431_+ | 4.24066628148934e-08 | 0.429219470955758 | 1.80709795395901e-15 | 0.590549220162489 | 0.13653910508167 | -0.122126441486041 |
| DLPFC | ADediting_1135877 | chr4_41265435_+ | 1.90184754730846e-09 | 0.332694471468405 | 4.16353600574062e-17 | 0.453199977466877 | 0.00371055541249842 | 0.16435152033883 |
| CER | ADediting_1135877 | chr4_41265435_+ | 4.99589976010772e-10 | 0.480259856040928 | 2.69961962490699e-12 | 0.531156130338909 | 0.00510021573306283 | 0.22756639299516 |
| TCX | ADediting_1135877 | chr4_41265435_+ | 5.82962011958491e-09 | 0.453066010402409 | 2.65326952873544e-11 | 0.509903459615083 | 0.123031268717973 | -0.126469821734488 |
| DLPFC | ADediting_1135879 | chr4_41265463_+ | 1.9458237439161e-06 | 0.266465270419976 | 1.32188338233638e-11 | 0.37192472106736 | 0.00120901155336182 | 0.183018981397212 |
| CER | ADediting_1135879 | chr4_41265463_+ | 1.83405461886946e-09 | 0.466162511562285 | 1.20744135256755e-09 | 0.470764039887356 | 0.00128252622051214 | 0.260524785823635 |
| TCX | ADediting_1135879 | chr4_41265463_+ | 1.09479618058225e-09 | 0.471832306838549 | 3.62285698540285e-09 | 0.45852018585129 | 0.685845971612394 | -0.0332965677328267 |
| CER | ADediting_1135884 | chr4_41265529_+ | 4.39233445185212e-07 | 0.398538903213982 | 2.12702951886539e-07 | 0.408387446562483 | 0.0121349280294553 | 0.204337169560982 |
| TCX | ADediting_1135884 | chr4_41265529_+ | 0.000267181051449748 | 0.293502497289221 | 1.10905300254462e-09 | 0.47169138790084 | 0.319019866186326 | -0.0819101706267237 |
| CER | ADediting_1135885 | chr4_41265536_+ | 0.00180572361927932 | 0.252748511791387 | 1.29176205898456e-06 | 0.383272956532894 | 0.12421379002082 | 0.126075319695799 |
| TCX | ADediting_1135885 | chr4_41265536_+ | 0.000212475935811278 | 0.297998685828787 | 0.000150035521740921 | 0.304690605285835 | 0.920466775173068 | 0.00822100749657452 |
| DLPFC | ADediting_1135891 | chr4_41266644_+ | 1.18812345601055e-05 | 0.245916418659368 | 3.28709623423274e-09 | 0.328021080878541 | 0.772557368575111 | 0.0164813444840622 |
| DLPFC | ADediting_1135895 | chr4_41266753_+ | 1.65315111150408e-07 | 0.291982979036409 | 1.19155346952197e-11 | 0.372689668979117 | 0.0359111699687243 | 0.119210886699737 |
| CER | ADediting_1135895 | chr4_41266753_+ | 1.93967631133695e-06 | 0.377314503636462 | 2.05747952162512e-08 | 0.438124709905408 | 0.00494543952638403 | 0.228351970293154 |
| TCX | ADediting_1135895 | chr4_41266753_+ | 9.60356532143312e-07 | 0.387545394303001 | 6.55496172265631e-09 | 0.451706561950692 | 0.674291492965965 | -0.034593653861467 |
| DLPFC | ADediting_1135897 | chr4_41266759_+ | 5.68600914849282e-06 | 0.254498428849104 | 1.77926080898363e-09 | 0.333258192333981 | 0.179382805703314 | 0.0764550390585823 |
| CER | ADediting_1135897 | chr4_41266759_+ | 1.34694384728449e-07 | 0.414434141930539 | 2.67396973367307e-10 | 0.486814214350596 | 0.0546567508794022 | 0.157235536994118 |
| TCX | ADediting_1135897 | chr4_41266759_+ | 8.28462579801459e-07 | 0.389652193822221 | 6.07633455513859e-10 | 0.478178046578369 | 0.1851874343279 | -0.108770440260414 |
| DLPFC | ADediting_1135901 | chr4_41266781_+ | 1.14588377173252e-05 | 0.246345278921405 | 2.68334277422938e-10 | 0.348807599028173 | 0.173796095800932 | 0.0774456772749239 |
| CER | ADediting_1135901 | chr4_41266781_+ | 1.06274601976451e-08 | 0.446041236461584 | 9.00979560956312e-12 | 0.520131739417874 | 0.00458972374961765 | 0.230244363136722 |
| TCX | ADediting_1135901 | chr4_41266781_+ | 2.52967629525341e-08 | 0.435606748883813 | 7.34609113605972e-08 | 0.422278465731815 | 0.452957570702565 | 0.0617354969966181 |
| CER | ADediting_1135902 | chr4_41266785_+ | 0.00194230104717639 | 0.251060371662304 | 4.96352184314065e-05 | 0.324962071151803 | 0.0704780788121713 | 0.148113351639932 |
| CER | ADediting_1135903 | chr4_41266786_+ | 0.0010325609517977 | 0.265333953967366 | 2.1684288985586e-05 | 0.339248099283932 | 0.121282874214649 | 0.127058511954495 |
| DLPFC | ADediting_1135904 | chr4_41266792_+ | 1.2526371873969e-07 | 0.294701709648743 | 9.7080125421614e-11 | 0.356824332234738 | 0.37629603198026 | 0.0504216652490628 |
| CER | ADediting_1135904 | chr4_41266792_+ | 4.82271621123856e-05 | 0.325470608268894 | 1.88053472633655e-06 | 0.377772535182564 | 0.0737866050706739 | 0.146421272957168 |
| TCX | ADediting_1135904 | chr4_41266792_+ | 3.97287413490881e-06 | 0.366509008156233 | 0.000131538793228311 | 0.307179605398224 | 0.413202756310254 | 0.0672987002279656 |
| TCX | ADediting_1135907 | chr4_41266803_+ | 6.78916912161049e-05 | 0.319367961811832 | 0.00134029357233268 | 0.259536471130913 | 0.135731058915165 | -0.122376763043921 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 7.0826136167105e-79 | 0.826588067328948 | 2.26458351315314e-107 | 0.890525883949821 | 0.0298552741306996 | 0.123388297660905 |
| AC | 8.91739420259101e-79 | 0.871675788976527 | 8.50031245538456e-94 | 0.904558378591201 | 0.0288932104621063 | 0.138216531576986 |
| PCC | 9.66298634201923e-52 | 0.838576095797673 | 3.82756064400602e-59 | 0.867238592083567 | 0.751591443084914 | 0.0230524260505653 |
| CER | 8.08527094678781e-10 | 0.475115497720757 | 3.83485110430966e-11 | 0.50633605309733 | 3.75243365924132e-07 | 0.400704534157086 |
| TCX | 5.73364768456908e-19 | 0.644403140097204 | 6.29900436646335e-26 | 0.726883536051736 | 0.000111019900569197 | -0.310355568908372 |
| FP | 7.07120301509429e-22 | 0.639764296423599 | 2.72485029514878e-26 | 0.687973532127224 | 0.23455005452164 | -0.0895500723453037 |
| IFG | 0.000812648325914464 | 0.62617497208067 | 0.00518136360874322 | 0.541491794416722 | 0.0836324354234986 | -0.35283355518041 |
| PG | 4.19066116558485e-28 | 0.694457067533449 | 8.49115880156788e-24 | 0.650955392293392 | 0.00808640553876412 | -0.193656727096009 |
| STG | 2.3981645836232e-18 | 0.779650124985028 | 3.26869678247189e-16 | 0.747229674469584 | 0.120274278695693 | -0.170825241640698 |
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Relation with AD stages for UCHL1 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| CER | ADediting_1135823 | chr4_41262213_+ | 2.06681890944151e-05 | 0.397310231192563 |
| CER | ADediting_1135830 | chr4_41262266_+ | 0.00102597126753498 | 0.311655521735722 |
| CER | ADediting_1135847 | chr4_41262806_+ | 0.000804305939545697 | 0.317776144280465 |
| CER | ADediting_1135871 | chr4_41265422_+ | 6.76231277728336e-05 | 0.373765485896195 |
| CER | ADediting_1135876 | chr4_41265431_+ | 0.000526917371580287 | 0.328115002689046 |
| CER | ADediting_1135879 | chr4_41265463_+ | 0.000520850916034957 | 0.328393025970265 |
| TCX | ADediting_1135879 | chr4_41265463_+ | 0.00160321897834645 | 0.302832509177687 |
| TCX | ADediting_1135901 | chr4_41266781_+ | 0.00148334541436635 | 0.304897904519032 |
| IFG | ADediting_1135830 | chr4_41262266_+ | 0.0207536341168707 | 0.459784013623419 |
| IFG | ADediting_1135855 | chr4_41265301_+ | 0.0354713369979928 | 0.422303326441651 |
| IFG | ADediting_1135856 | chr4_41265321_+ | 0.0354713369979928 | 0.422303326441651 |
| IFG | ADediting_1135895 | chr4_41266753_+ | 0.0354713369979928 | 0.422303326441651 |
| IFG | ADediting_1135901 | chr4_41266781_+ | 0.0354713369979928 | 0.422303326441651 |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 0.000134375513647535 | 0.359251743030441 |
| PG | 2.69653782337778e-06 | -0.336276861833101 |
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RelatedDrugs for UCHL1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for UCHL1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| UCHL1 | C3150899 | PARKINSON DISEASE 5, AUTOSOMAL DOMINANT | 3 | CTD_human;UNIPROT |
| UCHL1 | C3809665 | SPASTIC PARAPLEGIA 79, AUTOSOMAL RECESSIVE | 2 | CTD_human;ORPHANET;UNIPROT |
| UCHL1 | C0004138 | Ataxias, Hereditary | 1 | GENOMICS_ENGLAND |
| UCHL1 | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
| UCHL1 | C0014859 | Esophageal Neoplasms | 1 | CTD_human |
| UCHL1 | C0016978 | gallbladder neoplasm | 1 | CTD_human |
| UCHL1 | C0019284 | Diaphragmatic Hernia | 1 | CTD_human |
| UCHL1 | C0031117 | Peripheral Neuropathy | 1 | CTD_human |
| UCHL1 | C0153452 | Malignant neoplasm of gallbladder | 1 | CTD_human |
| UCHL1 | C0546837 | Malignant neoplasm of esophagus | 1 | CTD_human |
| UCHL1 | C2239176 | Liver carcinoma | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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