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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for UBA1 |
 Gene summary |
| Gene information | Gene symbol | UBA1 | Gene ID | 7317 |
| Gene name | ubiquitin like modifier activating enzyme 1 | |
| Synonyms | A1S9|A1S9T|A1ST|AMCX1|CFAP124|GXP1|POC20|SMAX2|UBA1A|UBE1|UBE1X | |
| Cytomap | Xp11.3 | |
| Type of gene | protein-coding | |
| Description | ubiquitin-like modifier-activating enzyme 1A1S9T and BN75 temperature sensitivity complementingPOC20 centriolar protein homologUBA1, ubiquitin-activating enzyme E1 homolog Atesticular secretory protein Li 63 | |
| Modification date | 20200313 | |
| UniProtAcc | P22314, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| UBA1 | GO:0006974 | cellular response to DNA damage stimulus | 22456334 |
Top |
RNA A-to-I events for UBA1 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
 |
| RNA editing frequencies across three data sets. |
 |
| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
 |
| RNA A-to-I editing events in AD. |
| ADediting_1501413(47198627, +), ADediting_1501414(47203826, +), ADediting_1501415(47203829, +), ADediting_1501416(47203849, +), ADediting_1501417(47203878, +), ADediting_1501418(47203894, +), ADediting_1501419(47203922, +), ADediting_1501420(47203927, +), ADediting_1501421(47203957, +), ADediting_1501422(47204000, +), ADediting_1501423(47204010, +), ADediting_1501424(47204022, +), ADediting_1501425(47205599, +), ADediting_1501426(47205607, +), ADediting_1501427(47205608, +), ADediting_1501428(47205613, +), ADediting_1501429(47205644, +), ADediting_1501430(47205652, +), ADediting_1501431(47205675, +), ADediting_1501432(47205676, +), ADediting_1501433(47205678, +), ADediting_1501434(47205695, +), ADediting_1501435(47205698, +), ADediting_1501436(47205703, +), ADediting_1501437(47205704, +), ADediting_1501438(47205715, +), ADediting_1501439(47205723, +), ADediting_1501440(47205727, +), ADediting_1501441(47205743, +), ADediting_1501442(47205774, +), ADediting_1501443(47205783, +), ADediting_1501444(47205788, +), ADediting_1501445(47205795, +), ADediting_1501446(47208176, +), ADediting_1501447(47208188, +), ADediting_1501448(47208213, +), ADediting_1501449(47208214, +), ADediting_1501450(47208293, +), ADediting_1501451(47208373, +), ADediting_1501452(47208384, +), ADediting_1501453(47208399, +), ADediting_1501454(47208416, +), ADediting_1501455(47208426, +), ADediting_1501456(47208438, +), ADediting_1501457(47208446, +), ADediting_1501458(47208715, +), ADediting_1501459(47208739, +), ADediting_1501460(47208747, +), ADediting_1501461(47208748, +), ADediting_1501462(47208749, +), ADediting_1501463(47208761, +), ADediting_1501464(47208817, +), ADediting_1501465(47208829, +), ADediting_1501466(47208833, +), ADediting_1501467(47208835, +), ADediting_1501468(47208836, +), ADediting_1501469(47208848, +), ADediting_1501470(47208856, +), ADediting_1501471(47208857, +), ADediting_1501472(47208875, +), ADediting_1501473(47208880, +), ADediting_1501474(47208888, +), ADediting_1501475(47208889, +), ADediting_1501476(47208894, +), ADediting_1501477(47208899, +), ADediting_1501478(47208908, +), ADediting_1501479(47208911, +), ADediting_1501480(47208912, +), ADediting_1501481(47208925, +), ADediting_1501482(47208931, +), ADediting_1501483(47208938, +), ADediting_1501484(47208939, +), ADediting_1501485(47208940, +), ADediting_1501486(47208944, +), ADediting_1501487(47208976, +), ADediting_1501488(47208980, +), ADediting_1501489(47209012, +), ADediting_1501490(47209024, +), ADediting_1501491(47209025, +), ADediting_1501492(47209036, +), ADediting_1501493(47209176, +), ADediting_1501494(47209178, +), ADediting_1501495(47209180, +), ADediting_1501496(47209198, +), ADediting_1501497(47209210, +), ADediting_1501498(47209211, +), ADediting_1501499(47209229, +), ADediting_1501500(47209235, +), ADediting_1501501(47209271, +), ADediting_1501502(47209283, +), ADediting_1501503(47209293, +), ADediting_1501504(47209295, +), ADediting_1501505(47209299, +), ADediting_1501506(47209315, +), ADediting_1501507(47209339, +), ADediting_1501508(47209351, +), ADediting_1501509(47209354, +), ADediting_1501510(47209363, +), ADediting_1501511(47209406, +), ADediting_1501512(47209428, +), ADediting_1501513(47209430, +), ADediting_1595292(47203890, +), ADediting_1595293(47208385, +), ADediting_1595294(47208927, +), ADediting_1595295(47208987, +), ADediting_1675224(47208244, +), ADediting_1675225(47208960, +), |
Top |
RNA editing positional annotations for UBA1 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| ADediting_1501508 | chrX_47209351_+ | nonsynonymous SNV | ENST00000377269.3 | c.A11G | p.H4R | 0.0 | 0.004 | 0.0 |
| ADediting_1501509 | chrX_47209354_+ | nonsynonymous SNV | ENST00000377269.3 | c.A14G | p.H5R | 0.0 | 0.0 | 1.36 |
| ADediting_1501510 | chrX_47209363_+ | nonsynonymous SNV | ENST00000377269.3 | c.A23G | p.Q8R | 0.0 | 0.004 | 0.95 |
| ADediting_1501511 | chrX_47209406_+ | synonymous SNV | ENST00000377269.3 | c.A66G | p.L22L | . | . | . |
| ADediting_1501512 | chrX_47209428_+ | nonsynonymous SNV | ENST00000377269.3 | c.A88G | p.T30A | 0.268 | 0.0 | -0.01 |
| ADediting_1501513 | chrX_47209430_+ | synonymous SNV | ENST00000377269.3 | c.A90G | p.T30T | . | . | . |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_1501413 | chrX_47198627_+ | intronic |
| ADediting_1501414 | chrX_47203826_+ | intronic |
| ADediting_1501415 | chrX_47203829_+ | intronic |
| ADediting_1501416 | chrX_47203849_+ | intronic |
| ADediting_1501417 | chrX_47203878_+ | intronic |
| ADediting_1501418 | chrX_47203894_+ | intronic |
| ADediting_1501419 | chrX_47203922_+ | intronic |
| ADediting_1501420 | chrX_47203927_+ | intronic |
| ADediting_1501421 | chrX_47203957_+ | intronic |
| ADediting_1501422 | chrX_47204000_+ | intronic |
| ADediting_1501423 | chrX_47204010_+ | intronic |
| ADediting_1501424 | chrX_47204022_+ | intronic |
| ADediting_1501425 | chrX_47205599_+ | ncRNA_exonic |
| ADediting_1501426 | chrX_47205607_+ | ncRNA_exonic |
| ADediting_1501427 | chrX_47205608_+ | ncRNA_exonic |
| ADediting_1501428 | chrX_47205613_+ | ncRNA_exonic |
| ADediting_1501429 | chrX_47205644_+ | ncRNA_exonic |
| ADediting_1501430 | chrX_47205652_+ | ncRNA_exonic |
| ADediting_1501431 | chrX_47205675_+ | ncRNA_exonic |
| ADediting_1501432 | chrX_47205676_+ | ncRNA_exonic |
| ADediting_1501433 | chrX_47205678_+ | ncRNA_exonic |
| ADediting_1501434 | chrX_47205695_+ | ncRNA_exonic |
| ADediting_1501435 | chrX_47205698_+ | ncRNA_exonic |
| ADediting_1501436 | chrX_47205703_+ | ncRNA_exonic |
| ADediting_1501437 | chrX_47205704_+ | ncRNA_exonic |
| ADediting_1501438 | chrX_47205715_+ | ncRNA_exonic |
| ADediting_1501439 | chrX_47205723_+ | ncRNA_exonic |
| ADediting_1501440 | chrX_47205727_+ | ncRNA_exonic |
| ADediting_1501441 | chrX_47205743_+ | ncRNA_exonic |
| ADediting_1501442 | chrX_47205774_+ | ncRNA_exonic |
| ADediting_1501443 | chrX_47205783_+ | ncRNA_exonic |
| ADediting_1501444 | chrX_47205788_+ | ncRNA_exonic |
| ADediting_1501445 | chrX_47205795_+ | ncRNA_exonic |
| ADediting_1501446 | chrX_47208176_+ | intronic |
| ADediting_1501447 | chrX_47208188_+ | intronic |
| ADediting_1501448 | chrX_47208213_+ | intronic |
| ADediting_1501449 | chrX_47208214_+ | intronic |
| ADediting_1501450 | chrX_47208293_+ | intronic |
| ADediting_1501451 | chrX_47208373_+ | intronic |
| ADediting_1501452 | chrX_47208384_+ | intronic |
| ADediting_1501453 | chrX_47208399_+ | intronic |
| ADediting_1501454 | chrX_47208416_+ | intronic |
| ADediting_1501455 | chrX_47208426_+ | intronic |
| ADediting_1501456 | chrX_47208438_+ | intronic |
| ADediting_1501457 | chrX_47208446_+ | intronic |
| ADediting_1501458 | chrX_47208715_+ | UTR5 |
| ADediting_1501459 | chrX_47208739_+ | UTR5 |
| ADediting_1501460 | chrX_47208747_+ | UTR5 |
| ADediting_1501461 | chrX_47208748_+ | UTR5 |
| ADediting_1501462 | chrX_47208749_+ | UTR5 |
| ADediting_1501463 | chrX_47208761_+ | UTR5 |
| ADediting_1501464 | chrX_47208817_+ | UTR5 |
| ADediting_1501465 | chrX_47208829_+ | UTR5 |
| ADediting_1501466 | chrX_47208833_+ | UTR5 |
| ADediting_1501467 | chrX_47208835_+ | UTR5 |
| ADediting_1501468 | chrX_47208836_+ | UTR5 |
| ADediting_1501469 | chrX_47208848_+ | UTR5 |
| ADediting_1501470 | chrX_47208856_+ | UTR5 |
| ADediting_1501471 | chrX_47208857_+ | UTR5 |
| ADediting_1501472 | chrX_47208875_+ | UTR5 |
| ADediting_1501473 | chrX_47208880_+ | UTR5 |
| ADediting_1501474 | chrX_47208888_+ | UTR5 |
| ADediting_1501475 | chrX_47208889_+ | UTR5 |
| ADediting_1501476 | chrX_47208894_+ | UTR5 |
| ADediting_1501477 | chrX_47208899_+ | UTR5 |
| ADediting_1501478 | chrX_47208908_+ | UTR5 |
| ADediting_1501479 | chrX_47208911_+ | UTR5 |
| ADediting_1501480 | chrX_47208912_+ | UTR5 |
| ADediting_1501481 | chrX_47208925_+ | UTR5 |
| ADediting_1501482 | chrX_47208931_+ | UTR5 |
| ADediting_1501483 | chrX_47208938_+ | UTR5 |
| ADediting_1501484 | chrX_47208939_+ | UTR5 |
| ADediting_1501485 | chrX_47208940_+ | UTR5 |
| ADediting_1501486 | chrX_47208944_+ | UTR5 |
| ADediting_1501487 | chrX_47208976_+ | UTR5 |
| ADediting_1501488 | chrX_47208980_+ | UTR5 |
| ADediting_1501489 | chrX_47209012_+ | UTR5 |
| ADediting_1501490 | chrX_47209024_+ | UTR5 |
| ADediting_1501491 | chrX_47209025_+ | UTR5 |
| ADediting_1501492 | chrX_47209036_+ | UTR5 |
| ADediting_1501493 | chrX_47209176_+ | UTR5 |
| ADediting_1501494 | chrX_47209178_+ | UTR5 |
| ADediting_1501495 | chrX_47209180_+ | UTR5 |
| ADediting_1501496 | chrX_47209198_+ | UTR5 |
| ADediting_1501497 | chrX_47209210_+ | UTR5 |
| ADediting_1501498 | chrX_47209211_+ | UTR5 |
| ADediting_1501499 | chrX_47209229_+ | UTR5 |
| ADediting_1501500 | chrX_47209235_+ | UTR5 |
| ADediting_1501501 | chrX_47209271_+ | UTR5 |
| ADediting_1501502 | chrX_47209283_+ | UTR5 |
| ADediting_1501503 | chrX_47209293_+ | UTR5 |
| ADediting_1501504 | chrX_47209295_+ | UTR5 |
| ADediting_1501505 | chrX_47209299_+ | UTR5 |
| ADediting_1501506 | chrX_47209315_+ | UTR5 |
| ADediting_1501507 | chrX_47209339_+ | UTR5 |
| ADediting_1501508 | chrX_47209351_+ | exonic |
| ADediting_1501509 | chrX_47209354_+ | exonic |
| ADediting_1501510 | chrX_47209363_+ | exonic |
| ADediting_1501511 | chrX_47209406_+ | exonic |
| ADediting_1501512 | chrX_47209428_+ | exonic |
| ADediting_1501513 | chrX_47209430_+ | exonic |
| ADediting_1595292 | chrX_47203890_+ | intronic |
| ADediting_1595293 | chrX_47208385_+ | intronic |
| ADediting_1595294 | chrX_47208927_+ | UTR5 |
| ADediting_1595295 | chrX_47208987_+ | UTR5 |
| ADediting_1675224 | chrX_47208244_+ | intronic |
| ADediting_1675225 | chrX_47208960_+ | UTR5 |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_1501413 | chrX_47198627_+ | SINE | MIR | Name=MIR |
| ADediting_1501414 | chrX_47203826_+ | SINE | Alu | Name=AluSp |
| ADediting_1501415 | chrX_47203829_+ | SINE | Alu | Name=AluSp |
| ADediting_1501416 | chrX_47203849_+ | SINE | Alu | Name=AluSp |
| ADediting_1501417 | chrX_47203878_+ | SINE | Alu | Name=AluSp |
| ADediting_1501418 | chrX_47203894_+ | SINE | Alu | Name=AluSp |
| ADediting_1501419 | chrX_47203922_+ | SINE | Alu | Name=AluSp |
| ADediting_1501420 | chrX_47203927_+ | SINE | Alu | Name=AluSp |
| ADediting_1501421 | chrX_47203957_+ | SINE | Alu | Name=AluSp |
| ADediting_1501422 | chrX_47204000_+ | SINE | Alu | Name=AluSp |
| ADediting_1501423 | chrX_47204010_+ | SINE | Alu | Name=AluSp |
| ADediting_1501424 | chrX_47204022_+ | SINE | Alu | Name=AluSp |
| ADediting_1501425 | chrX_47205599_+ | SINE | Alu | Name=AluJb |
| ADediting_1501426 | chrX_47205607_+ | SINE | Alu | Name=AluJb |
| ADediting_1501427 | chrX_47205608_+ | SINE | Alu | Name=AluJb |
| ADediting_1501428 | chrX_47205613_+ | SINE | Alu | Name=AluJb |
| ADediting_1501429 | chrX_47205644_+ | SINE | Alu | Name=AluJb |
| ADediting_1501430 | chrX_47205652_+ | SINE | Alu | Name=AluJb |
| ADediting_1501431 | chrX_47205675_+ | SINE | Alu | Name=AluJb |
| ADediting_1501432 | chrX_47205676_+ | SINE | Alu | Name=AluJb |
| ADediting_1501433 | chrX_47205678_+ | SINE | Alu | Name=AluJb |
| ADediting_1501434 | chrX_47205695_+ | SINE | Alu | Name=AluJb |
| ADediting_1501435 | chrX_47205698_+ | SINE | Alu | Name=AluJb |
| ADediting_1501436 | chrX_47205703_+ | SINE | Alu | Name=AluJb |
| ADediting_1501437 | chrX_47205704_+ | SINE | Alu | Name=AluJb |
| ADediting_1501438 | chrX_47205715_+ | SINE | Alu | Name=AluJb |
| ADediting_1501439 | chrX_47205723_+ | SINE | Alu | Name=AluJb |
| ADediting_1501440 | chrX_47205727_+ | SINE | Alu | Name=AluJb |
| ADediting_1501441 | chrX_47205743_+ | SINE | Alu | Name=AluJb |
| ADediting_1501442 | chrX_47205774_+ | SINE | Alu | Name=AluJb |
| ADediting_1501443 | chrX_47205783_+ | SINE | Alu | Name=AluJb |
| ADediting_1501444 | chrX_47205788_+ | SINE | Alu | Name=AluJb |
| ADediting_1501445 | chrX_47205795_+ | SINE | Alu | Name=AluJb |
| ADediting_1501446 | chrX_47208176_+ | SINE | Alu | Name=AluJo |
| ADediting_1501447 | chrX_47208188_+ | SINE | Alu | Name=AluJo |
| ADediting_1501448 | chrX_47208213_+ | SINE | Alu | Name=AluJo |
| ADediting_1501449 | chrX_47208214_+ | SINE | Alu | Name=AluJo |
| ADediting_1501450 | chrX_47208293_+ | SINE | Alu | Name=AluJo |
| ADediting_1501451 | chrX_47208373_+ | SINE | Alu | Name=AluJo |
| ADediting_1501452 | chrX_47208384_+ | SINE | Alu | Name=AluJo |
| ADediting_1501453 | chrX_47208399_+ | SINE | Alu | Name=AluJo |
| ADediting_1501454 | chrX_47208416_+ | SINE | Alu | Name=AluJo |
| ADediting_1501455 | chrX_47208426_+ | SINE | Alu | Name=AluJo |
| ADediting_1501456 | chrX_47208438_+ | SINE | Alu | Name=AluJo |
| ADediting_1501457 | chrX_47208446_+ | SINE | Alu | Name=AluJo |
| ADediting_1501458 | chrX_47208715_+ | SINE | Alu | Name=AluSq |
| ADediting_1501459 | chrX_47208739_+ | SINE | Alu | Name=AluSq |
| ADediting_1501460 | chrX_47208747_+ | SINE | Alu | Name=AluSq |
| ADediting_1501461 | chrX_47208748_+ | SINE | Alu | Name=AluSq |
| ADediting_1501462 | chrX_47208749_+ | SINE | Alu | Name=AluSq |
| ADediting_1501463 | chrX_47208761_+ | SINE | Alu | Name=AluSq |
| ADediting_1501464 | chrX_47208817_+ | SINE | Alu | Name=AluJb |
| ADediting_1501465 | chrX_47208829_+ | SINE | Alu | Name=AluJb |
| ADediting_1501466 | chrX_47208833_+ | SINE | Alu | Name=AluJb |
| ADediting_1501467 | chrX_47208835_+ | SINE | Alu | Name=AluJb |
| ADediting_1501468 | chrX_47208836_+ | SINE | Alu | Name=AluJb |
| ADediting_1501469 | chrX_47208848_+ | SINE | Alu | Name=AluJb |
| ADediting_1501470 | chrX_47208856_+ | SINE | Alu | Name=AluJb |
| ADediting_1501471 | chrX_47208857_+ | SINE | Alu | Name=AluJb |
| ADediting_1501472 | chrX_47208875_+ | SINE | Alu | Name=AluJb |
| ADediting_1501473 | chrX_47208880_+ | SINE | Alu | Name=AluJb |
| ADediting_1501474 | chrX_47208888_+ | SINE | Alu | Name=AluJb |
| ADediting_1501475 | chrX_47208889_+ | SINE | Alu | Name=AluJb |
| ADediting_1501476 | chrX_47208894_+ | SINE | Alu | Name=AluJb |
| ADediting_1501477 | chrX_47208899_+ | SINE | Alu | Name=AluJb |
| ADediting_1501478 | chrX_47208908_+ | SINE | Alu | Name=AluJb |
| ADediting_1501479 | chrX_47208911_+ | SINE | Alu | Name=AluJb |
| ADediting_1501480 | chrX_47208912_+ | SINE | Alu | Name=AluJb |
| ADediting_1501481 | chrX_47208925_+ | SINE | Alu | Name=AluJb |
| ADediting_1501482 | chrX_47208931_+ | SINE | Alu | Name=AluJb |
| ADediting_1501483 | chrX_47208938_+ | SINE | Alu | Name=AluJb |
| ADediting_1501484 | chrX_47208939_+ | SINE | Alu | Name=AluJb |
| ADediting_1501485 | chrX_47208940_+ | SINE | Alu | Name=AluJb |
| ADediting_1501486 | chrX_47208944_+ | SINE | Alu | Name=AluJb |
| ADediting_1501487 | chrX_47208976_+ | SINE | Alu | Name=AluJb |
| ADediting_1501488 | chrX_47208980_+ | SINE | Alu | Name=AluJb |
| ADediting_1501489 | chrX_47209012_+ | SINE | Alu | Name=AluJb |
| ADediting_1501490 | chrX_47209024_+ | SINE | Alu | Name=AluJb |
| ADediting_1501491 | chrX_47209025_+ | SINE | Alu | Name=AluJb |
| ADediting_1501492 | chrX_47209036_+ | SINE | Alu | Name=AluJb |
| ADediting_1501493 | chrX_47209176_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1501494 | chrX_47209178_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1501495 | chrX_47209180_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1501496 | chrX_47209198_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1501497 | chrX_47209210_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1501498 | chrX_47209211_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1501499 | chrX_47209229_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1501500 | chrX_47209235_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1501501 | chrX_47209271_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1501502 | chrX_47209283_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1501503 | chrX_47209293_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1501504 | chrX_47209295_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1501505 | chrX_47209299_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1501506 | chrX_47209315_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1501507 | chrX_47209339_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1501508 | chrX_47209351_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1501509 | chrX_47209354_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1501510 | chrX_47209363_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1501511 | chrX_47209406_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1501512 | chrX_47209428_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1501513 | chrX_47209430_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1595292 | chrX_47203890_+ | SINE | Alu | Name=AluSp |
| ADediting_1595293 | chrX_47208385_+ | SINE | Alu | Name=AluJo |
| ADediting_1595294 | chrX_47208927_+ | SINE | Alu | Name=AluJb |
| ADediting_1595295 | chrX_47208987_+ | SINE | Alu | Name=AluJb |
| ADediting_1675224 | chrX_47208244_+ | SINE | Alu | Name=AluJo |
| ADediting_1675225 | chrX_47208960_+ | SINE | Alu | Name=AluJb |
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RNA A-to-I editing events in the alternative splicing sites for UBA1 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| A5SS | ADediting_1501413 | chrX_47198627_+ | 47198626:47198634 | 5ss | 2e | TAGGTCTGA | 1.23 | TGGGTCTGA | -2.19 |
| ES | ADediting_1501413 | chrX_47198627_+ | 47198626:47198634 | 5ss | 2e | TAGGTCTGA | 1.23 | TGGGTCTGA | -2.19 |
| ES | ADediting_1501413 | chrX_47198627_+ | 47198626:47198634 | 5ss | 2e | TAGGTCTGA | 1.23 | TGGGTCTGA | -2.19 |
| ES | ADediting_1501413 | chrX_47198627_+ | 47198626:47198634 | 5ss | 2e | TAGGTCTGA | 1.23 | TGGGTCTGA | -2.19 |
| ES | ADediting_1501413 | chrX_47198627_+ | 47198626:47198634 | 5ss | 2e | TAGGTCTGA | 1.23 | TGGGTCTGA | -2.19 |
| ME2 | ADediting_1501413 | chrX_47198627_+ | 47198626:47198634 | 5ss | 2e | TAGGTCTGA | 1.23 | TGGGTCTGA | -2.19 |
| ME2 | ADediting_1501413 | chrX_47198627_+ | 47198626:47198634 | 5ss | 2e | TAGGTCTGA | 1.23 | TGGGTCTGA | -2.19 |
| ME2 | ADediting_1501413 | chrX_47198627_+ | 47198626:47198634 | 5ss | 2e | TAGGTCTGA | 1.23 | TGGGTCTGA | -2.19 |
| ME2 | ADediting_1501413 | chrX_47198627_+ | 47198626:47198634 | 5ss | 2e | TAGGTCTGA | 1.23 | TGGGTCTGA | -2.19 |
| ME2 | ADediting_1501413 | chrX_47198627_+ | 47198626:47198634 | 5ss | 2e | TAGGTCTGA | 1.23 | TGGGTCTGA | -2.19 |
| ME2 | ADediting_1501413 | chrX_47198627_+ | 47198626:47198634 | 5ss | 2e | TAGGTCTGA | 1.23 | TGGGTCTGA | -2.19 |
| ME2 | ADediting_1501413 | chrX_47198627_+ | 47198626:47198634 | 5ss | 2e | TAGGTCTGA | 1.23 | TGGGTCTGA | -2.19 |
| ME2 | ADediting_1501413 | chrX_47198627_+ | 47198626:47198634 | 5ss | 2e | TAGGTCTGA | 1.23 | TGGGTCTGA | -2.19 |
| ME2 | ADediting_1501413 | chrX_47198627_+ | 47198626:47198634 | 5ss | 2e | TAGGTCTGA | 1.23 | TGGGTCTGA | -2.19 |
| ME2 | ADediting_1501413 | chrX_47198627_+ | 47198626:47198634 | 5ss | 2e | TAGGTCTGA | 1.23 | TGGGTCTGA | -2.19 |
| ME2 | ADediting_1501413 | chrX_47198627_+ | 47198626:47198634 | 5ss | 2e | TAGGTCTGA | 1.23 | TGGGTCTGA | -2.19 |
| ME2 | ADediting_1501413 | chrX_47198627_+ | 47198626:47198634 | 5ss | 2e | TAGGTCTGA | 1.23 | TGGGTCTGA | -2.19 |
| ME2 | ADediting_1501413 | chrX_47198627_+ | 47198626:47198634 | 5ss | 2e | TAGGTCTGA | 1.23 | TGGGTCTGA | -2.19 |
| ME2 | ADediting_1501413 | chrX_47198627_+ | 47198626:47198634 | 5ss | 2e | TAGGTCTGA | 1.23 | TGGGTCTGA | -2.19 |
| ME2 | ADediting_1501413 | chrX_47198627_+ | 47198626:47198634 | 5ss | 2e | TAGGTCTGA | 1.23 | TGGGTCTGA | -2.19 |
| ME2 | ADediting_1501413 | chrX_47198627_+ | 47198626:47198634 | 5ss | 2e | TAGGTCTGA | 1.23 | TGGGTCTGA | -2.19 |
| ME2 | ADediting_1501413 | chrX_47198627_+ | 47198626:47198634 | 5ss | 2e | TAGGTCTGA | 1.23 | TGGGTCTGA | -2.19 |
| ME2 | ADediting_1501413 | chrX_47198627_+ | 47198626:47198634 | 5ss | 2e | TAGGTCTGA | 1.23 | TGGGTCTGA | -2.19 |
| ME2 | ADediting_1501413 | chrX_47198627_+ | 47198626:47198634 | 5ss | 2e | TAGGTCTGA | 1.23 | TGGGTCTGA | -2.19 |
| ME2 | ADediting_1501413 | chrX_47198627_+ | 47198626:47198634 | 5ss | 2e | TAGGTCTGA | 1.23 | TGGGTCTGA | -2.19 |
| ME2 | ADediting_1501413 | chrX_47198627_+ | 47198626:47198634 | 5ss | 2e | TAGGTCTGA | 1.23 | TGGGTCTGA | -2.19 |
| ME2 | ADediting_1501413 | chrX_47198627_+ | 47198626:47198634 | 5ss | 2e | TAGGTCTGA | 1.23 | TGGGTCTGA | -2.19 |
| ME2 | ADediting_1501413 | chrX_47198627_+ | 47198626:47198634 | 5ss | 2e | TAGGTCTGA | 1.23 | TGGGTCTGA | -2.19 |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for UBA1 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
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| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for UBA1 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for UBA1 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1337758 | chr7_5495892_- | ENSG00000130985.17 | ENST00000335972.11 | UBA1-201 | hsa-miR-589-5p | chrX | 47214990 | 47214997 | 8mer-1a | 47214980 | 47214997 | 143 | -20.16 |
| ADediting_1337758 | chr7_5495892_- | ENSG00000130985.17 | ENST00000377269.3 | UBA1-202 | hsa-miR-589-5p | chrX | 47214990 | 47214997 | 8mer-1a | 47214980 | 47214997 | 143 | -20.16 |
| ADediting_1337758 | chr7_5495892_- | ENSG00000130985.17 | ENST00000377351.8 | UBA1-203 | hsa-miR-589-5p | chrX | 47214990 | 47214997 | 8mer-1a | 47214980 | 47214997 | 143 | -20.16 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for UBA1 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000377269.3 | protein_coding |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_1501458 | ENST00000377269.3 | chrX_47208715_+ | 154 | -1033.90 | -1029.80 | -1102.20 |
| ADediting_1501459 | ENST00000377269.3 | chrX_47208739_+ | 178 | -1029.30 | -1029.80 | -1102.20 |
| ADediting_1501460 | ENST00000377269.3 | chrX_47208747_+ | 186 | -1029.90 | -1029.80 | -1102.20 |
| ADediting_1501461 | ENST00000377269.3 | chrX_47208748_+ | 187 | -1032.20 | -1029.80 | -1102.20 |
| ADediting_1501462 | ENST00000377269.3 | chrX_47208749_+ | 188 | -1030.20 | -1029.80 | -1102.20 |
| ADediting_1501463 | ENST00000377269.3 | chrX_47208761_+ | 200 | -1029.90 | -1029.80 | -1102.20 |
| ADediting_1501464 | ENST00000377269.3 | chrX_47208817_+ | 256 | -1026.40 | -1029.80 | -1102.20 |
| ADediting_1501465 | ENST00000377269.3 | chrX_47208829_+ | 268 | -1029.40 | -1029.80 | -1102.20 |
| ADediting_1501466 | ENST00000377269.3 | chrX_47208833_+ | 272 | -1036.00 | -1029.80 | -1102.20 |
| ADediting_1501467 | ENST00000377269.3 | chrX_47208835_+ | 274 | -1029.90 | -1029.80 | -1102.20 |
| ADediting_1501468 | ENST00000377269.3 | chrX_47208836_+ | 275 | -1029.80 | -1029.80 | -1102.20 |
| ADediting_1501469 | ENST00000377269.3 | chrX_47208848_+ | 287 | -1033.40 | -1029.80 | -1102.20 |
| ADediting_1501470 | ENST00000377269.3 | chrX_47208856_+ | 295 | -1030.20 | -1029.80 | -1102.20 |
| ADediting_1501471 | ENST00000377269.3 | chrX_47208857_+ | 296 | -1029.90 | -1029.80 | -1102.20 |
| ADediting_1501472 | ENST00000377269.3 | chrX_47208875_+ | 314 | -1028.90 | -1029.80 | -1102.20 |
| ADediting_1501473 | ENST00000377269.3 | chrX_47208880_+ | 319 | -1029.00 | -1029.80 | -1102.20 |
| ADediting_1501474 | ENST00000377269.3 | chrX_47208888_+ | 327 | -1035.80 | -1029.80 | -1102.20 |
| ADediting_1501475 | ENST00000377269.3 | chrX_47208889_+ | 328 | -1029.70 | -1029.80 | -1102.20 |
| ADediting_1501476 | ENST00000377269.3 | chrX_47208894_+ | 333 | -1029.10 | -1029.80 | -1102.20 |
| ADediting_1501477 | ENST00000377269.3 | chrX_47208899_+ | 338 | -1035.30 | -1029.80 | -1102.20 |
| ADediting_1501478 | ENST00000377269.3 | chrX_47208908_+ | 347 | -1036.40 | -1029.80 | -1102.20 |
| ADediting_1501479 | ENST00000377269.3 | chrX_47208911_+ | 350 | -1034.00 | -1029.80 | -1102.20 |
| ADediting_1501480 | ENST00000377269.3 | chrX_47208912_+ | 351 | -1029.20 | -1029.80 | -1102.20 |
| ADediting_1501481 | ENST00000377269.3 | chrX_47208925_+ | 364 | -1029.80 | -1029.80 | -1102.20 |
| ADediting_1595294 | ENST00000377269.3 | chrX_47208927_+ | 366 | -1030.80 | -1029.80 | -1102.20 |
| ADediting_1501482 | ENST00000377269.3 | chrX_47208931_+ | 370 | -1029.90 | -1029.80 | -1102.20 |
| ADediting_1501483 | ENST00000377269.3 | chrX_47208938_+ | 377 | -1029.90 | -1029.80 | -1102.20 |
| ADediting_1501484 | ENST00000377269.3 | chrX_47208939_+ | 378 | -1029.90 | -1029.80 | -1102.20 |
| ADediting_1501485 | ENST00000377269.3 | chrX_47208940_+ | 379 | -1029.90 | -1029.80 | -1102.20 |
| ADediting_1501486 | ENST00000377269.3 | chrX_47208944_+ | 383 | -1029.50 | -1029.80 | -1102.20 |
| ADediting_1675225 | ENST00000377269.3 | chrX_47208960_+ | 399 | -1029.10 | -1029.80 | -1102.20 |
| ADediting_1501487 | ENST00000377269.3 | chrX_47208976_+ | 415 | -1029.10 | -1029.80 | -1102.20 |
| ADediting_1501488 | ENST00000377269.3 | chrX_47208980_+ | 419 | -1026.80 | -1029.80 | -1102.20 |
| ADediting_1595295 | ENST00000377269.3 | chrX_47208987_+ | 426 | -1028.90 | -1029.80 | -1102.20 |
| ADediting_1501489 | ENST00000377269.3 | chrX_47209012_+ | 451 | -1029.80 | -1029.80 | -1102.20 |
| ADediting_1501490 | ENST00000377269.3 | chrX_47209024_+ | 463 | -1032.80 | -1029.80 | -1102.20 |
| ADediting_1501491 | ENST00000377269.3 | chrX_47209025_+ | 464 | -1029.30 | -1029.80 | -1102.20 |
| ADediting_1501492 | ENST00000377269.3 | chrX_47209036_+ | 475 | -1028.90 | -1029.80 | -1102.20 |
| ADediting_1501493 | ENST00000377269.3 | chrX_47209176_+ | 615 | -1028.90 | -1029.80 | -1102.20 |
| ADediting_1501494 | ENST00000377269.3 | chrX_47209178_+ | 617 | -1029.20 | -1029.80 | -1102.20 |
| ADediting_1501495 | ENST00000377269.3 | chrX_47209180_+ | 619 | -1029.80 | -1029.80 | -1102.20 |
| ADediting_1501496 | ENST00000377269.3 | chrX_47209198_+ | 637 | -1035.00 | -1029.80 | -1102.20 |
| ADediting_1501497 | ENST00000377269.3 | chrX_47209210_+ | 649 | -1029.10 | -1029.80 | -1102.20 |
| ADediting_1501498 | ENST00000377269.3 | chrX_47209211_+ | 650 | -1036.30 | -1029.80 | -1102.20 |
| ADediting_1501499 | ENST00000377269.3 | chrX_47209229_+ | 668 | -1029.40 | -1029.80 | -1102.20 |
| ADediting_1501500 | ENST00000377269.3 | chrX_47209235_+ | 674 | -1036.50 | -1029.80 | -1102.20 |
| ADediting_1501501 | ENST00000377269.3 | chrX_47209271_+ | 710 | -1029.10 | -1029.80 | -1102.20 |
| ADediting_1501502 | ENST00000377269.3 | chrX_47209283_+ | 722 | -1029.50 | -1029.80 | -1102.20 |
| ADediting_1501503 | ENST00000377269.3 | chrX_47209293_+ | 732 | -1034.00 | -1029.80 | -1102.20 |
| ADediting_1501504 | ENST00000377269.3 | chrX_47209295_+ | 734 | -1029.10 | -1029.80 | -1102.20 |
| ADediting_1501505 | ENST00000377269.3 | chrX_47209299_+ | 738 | -1026.70 | -1029.80 | -1102.20 |
| ADediting_1501506 | ENST00000377269.3 | chrX_47209315_+ | 754 | -1036.00 | -1029.80 | -1102.20 |
| ADediting_1501507 | ENST00000377269.3 | chrX_47209339_+ | 778 | -1028.90 | -1029.80 | -1102.20 |
| ADediting_1501508 | ENST00000377269.3 | chrX_47209351_+ | 790 | -1033.40 | -1029.80 | -1102.20 |
| ADediting_1501509 | ENST00000377269.3 | chrX_47209354_+ | 793 | -1030.10 | -1029.80 | -1102.20 |
| ADediting_1501510 | ENST00000377269.3 | chrX_47209363_+ | 802 | -1029.80 | -1029.80 | -1102.20 |
| ADediting_1501511 | ENST00000377269.3 | chrX_47209406_+ | 845 | -1036.40 | -1029.80 | -1102.20 |
| ADediting_1501512 | ENST00000377269.3 | chrX_47209428_+ | 867 | -1029.50 | -1029.80 | -1102.20 |
| ADediting_1501513 | ENST00000377269.3 | chrX_47209430_+ | 869 | -1029.80 | -1029.80 | -1102.20 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for UBA1 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | ADediting_1501414 | chrX_47203826_+ | 6.03443059021113e-10 | 0.34225118583268 | 5.52776841316036e-10 | 0.342968062605335 | 0.000751258753021417 | 0.190426773367595 |
| DLPFC | ADediting_1501416 | chrX_47203849_+ | 1.57022451270451e-13 | 0.402939213028299 | 7.2801989344881e-13 | 0.392571868635167 | 0.00314383170275044 | 0.16722971196585 |
| DLPFC | ADediting_1501420 | chrX_47203927_+ | 0.000258978211556449 | 0.206089471044137 | 0.0524248081764046 | 0.110272807450493 | 5.27838533904729e-09 | 0.323911142626758 |
| DLPFC | ADediting_1501422 | chrX_47204000_+ | 5.32354960385274e-08 | 0.302914160263805 | 4.04900642108967e-06 | 0.258351489947901 | 4.09694376738365e-06 | 0.258218947039265 |
| DLPFC | ADediting_1501429 | chrX_47205644_+ | 3.49027685478183e-08 | 0.306873872291254 | 4.87370587030302e-06 | 0.256255374398825 | 1.61903214727601e-05 | 0.242217984483446 |
| DLPFC | ADediting_1501435 | chrX_47205698_+ | 0.0221492991012588 | 0.129911879100203 | 0.982795955799785 | 0.00122970555034551 | 1.77667805044087e-13 | 0.402117584982861 |
| DLPFC | ADediting_1501445 | chrX_47205795_+ | 2.45493772780042e-10 | 0.349518152073617 | 9.67488977003863e-08 | 0.297207831855299 | 7.87441985081542e-07 | 0.276128812573591 |
| DLPFC | ADediting_1501447 | chrX_47208188_+ | 3.70011533980077e-10 | 0.346226387582993 | 4.03037233446811e-13 | 0.39661120286148 | 0.39084781577868 | 0.0489041113700513 |
| DLPFC | ADediting_1501451 | chrX_47208373_+ | 1.57148536855336e-07 | 0.292481566013383 | 4.62747331195881e-11 | 0.362528386525186 | 0.171545285454263 | 0.0778514821084483 |
| AC | ADediting_1501451 | chrX_47208373_+ | 0.786635459821698 | 0.0172043995046832 | 0.0453083707208359 | -0.126727916158286 | 6.57967206271285e-07 | 0.30838954182977 |
| DLPFC | ADediting_1501452 | chrX_47208384_+ | 1.52468713487295e-05 | 0.242940114985697 | 1.86822129802455e-09 | 0.332845514828391 | 0.0211260888507812 | 0.13092104066355 |
| DLPFC | ADediting_1501454 | chrX_47208416_+ | 8.99563825596485e-08 | 0.297909801648969 | 5.73011705015661e-14 | 0.409561120862092 | 0.0725307861477534 | 0.102138719777679 |
| DLPFC | ADediting_1501458 | chrX_47208715_+ | 5.89514999549438e-05 | 0.226100564841264 | 7.086027791624e-08 | 0.300197794387874 | 0.00241390212744084 | 0.171727536510677 |
| CER | ADediting_1501458 | chrX_47208715_+ | 0.000160423494894761 | 0.303415582615807 | 7.44501479268273e-05 | 0.317699780684229 | 0.0847955120938853 | 0.141199642552607 |
| DLPFC | ADediting_1501459 | chrX_47208739_+ | 1.7722040714787e-07 | 0.291297038893703 | 1.31330912829354e-13 | 0.404123623115559 | 0.00492864656270668 | 0.159314024329799 |
| DLPFC | ADediting_1501462 | chrX_47208749_+ | 3.58459214512447e-08 | 0.306625508363209 | 1.19425002097539e-13 | 0.404751686612303 | 0.0224372156840875 | 0.129635198705153 |
| CER | ADediting_1501462 | chrX_47208749_+ | 5.49378631271997e-05 | 0.323161185792502 | 4.22157919980713e-06 | 0.365575733716405 | 0.605272059753427 | -0.0425360438911025 |
| TCX | ADediting_1501462 | chrX_47208749_+ | 0.0443388956670473 | 0.164443240738452 | 2.7272307744488e-06 | 0.372227304875637 | 0.245671452504418 | -0.0953709066827083 |
| DLPFC | ADediting_1501465 | chrX_47208829_+ | 2.08536621717891e-10 | 0.350816711033969 | 1.69957728509475e-13 | 0.402412941019452 | 0.194166772136202 | 0.0739390996800835 |
| DLPFC | ADediting_1501466 | chrX_47208833_+ | 1.74161837738643e-07 | 0.291468930721667 | 3.28097432999172e-13 | 0.398003731527095 | 0.00378429013985999 | 0.164006811190741 |
| CER | ADediting_1501466 | chrX_47208833_+ | 1.01075707950433e-06 | 0.386812523426761 | 5.80988874273655e-08 | 0.425261283503762 | 0.102818048568238 | 0.133718295923251 |
| DLPFC | ADediting_1501470 | chrX_47208856_+ | 2.088627774733e-09 | 0.331899917250916 | 2.84124109683006e-15 | 0.428470354486613 | 0.00389030044197728 | 0.163521709281243 |
| DLPFC | ADediting_1501471 | chrX_47208857_+ | 8.74163838932344e-12 | 0.374960456940119 | 2.04300010698e-17 | 0.45717794428429 | 0.00246220800228559 | 0.17139393118562 |
| DLPFC | ADediting_1501473 | chrX_47208880_+ | 3.8114306976056e-09 | 0.326743342742215 | 3.99812288957008e-13 | 0.396665707058574 | 0.0536332272164346 | 0.109716665983551 |
| CER | ADediting_1501473 | chrX_47208880_+ | 1.2586458654477e-05 | 0.348263702645564 | 0.00484139173819769 | 0.228892537413829 | 0.551949135126574 | 0.0489489937118604 |
| DLPFC | ADediting_1501474 | chrX_47208888_+ | 9.47829348574577e-06 | 0.248580761148954 | 2.96827324671524e-09 | 0.328898461959849 | 0.000153204261693236 | 0.213400070192831 |
| CER | ADediting_1501477 | chrX_47208899_+ | 0.000327188623155544 | 0.289463771490965 | 6.4683089941411e-06 | 0.358933368447757 | 0.298879312898122 | 0.0853801519925633 |
| CER | ADediting_1501478 | chrX_47208908_+ | 0.0745935529183294 | 0.14601792081605 | 0.000163718453577457 | 0.303027202443936 | 0.0904320501124603 | 0.138734150619827 |
| DLPFC | ADediting_1501485 | chrX_47208940_+ | 2.05852149826876e-08 | 0.31174514767273 | 1.11964775568851e-09 | 0.337145856801181 | 0.0541660592907241 | 0.109474747767806 |
| DLPFC | ADediting_1501487 | chrX_47208976_+ | 3.49403234335297e-09 | 0.327494714560222 | 7.13609451582067e-14 | 0.408132140294135 | 0.955779220288886 | 0.00316216784077777 |
| CER | ADediting_1501488 | chrX_47208980_+ | 0.00201837978998017 | 0.250166267549958 | 1.87378621377894e-09 | 0.465924747330668 | 0.403070237303798 | 0.0687657966953196 |
| CER | ADediting_1501490 | chrX_47209024_+ | 0.000634974360313261 | 0.275809817994956 | 4.98408754566279e-06 | 0.363008625133167 | 0.109124372252693 | -0.131345682283929 |
| TCX | ADediting_1501490 | chrX_47209024_+ | 0.0158788471635791 | 0.196632074811581 | 9.08612179900403e-10 | 0.473855497534671 | 0.145851301992401 | -0.119320095465977 |
| DLPFC | ADediting_1501494 | chrX_47209178_+ | 1.07712574621586e-05 | 0.247076593940978 | 8.70288653214013e-10 | 0.33923801753121 | 0.0136007093670723 | 0.140027029332286 |
| DLPFC | ADediting_1501495 | chrX_47209180_+ | 4.6922314504864e-07 | 0.281496635175808 | 4.7113722556928e-14 | 0.410830208655083 | 0.00301088674388731 | 0.167972749106504 |
| DLPFC | ADediting_1501496 | chrX_47209198_+ | 8.67238532260819e-05 | 0.221055009404644 | 9.902173099045e-09 | 0.318354643911826 | 0.696301736673369 | -0.022255709511246 |
| TCX | ADediting_1501496 | chrX_47209198_+ | 0.170345309981605 | 0.112534903505657 | 3.05063243917888e-05 | 0.33344479448718 | 0.214594356549975 | -0.10191825369272 |
| DLPFC | ADediting_1501498 | chrX_47209211_+ | 0.000176488194341805 | 0.211454249817194 | 5.10111860347025e-09 | 0.32420964289571 | 0.720603735500159 | -0.0203935425169108 |
| DLPFC | ADediting_1501501 | chrX_47209271_+ | 0.000160559892475659 | 0.212757059486598 | 3.74440607831591e-09 | 0.326896825156545 | 0.995594904948092 | 0.000314843383454642 |
| DLPFC | ADediting_1501503 | chrX_47209293_+ | 0.00020667481415009 | 0.209261736041445 | 1.62446960527277e-10 | 0.352793154278884 | 0.00228046785678943 | 0.17268168927998 |
| DLPFC | ADediting_1501504 | chrX_47209295_+ | 9.79856735768854e-08 | 0.297085147964497 | 2.94537677198014e-15 | 0.428250656818477 | 0.156213450204038 | 0.0807272027033745 |
| DLPFC | ADediting_1501506 | chrX_47209315_+ | 2.36205618420956e-05 | 0.237623072963255 | 3.11155077983339e-08 | 0.307941128295414 | 0.000628425212422699 | 0.193137139819172 |
| DLPFC | ADediting_1501509 | chrX_47209354_+ | 6.62449888469978e-06 | 0.252744568978189 | 2.46796549761753e-11 | 0.367280713352115 | 0.0110465714318636 | 0.144159413814308 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 5.39439685605883e-58 | 0.753279653644675 | 5.04057312334637e-49 | 0.711001928814549 | 1.0904410341218e-23 | 0.528360240246673 |
| AC | 9.60261039974556e-86 | 0.888221264328214 | 4.87829948882065e-51 | 0.773547671704729 | 2.20454716844635e-20 | 0.540710757088217 |
| PCC | 9.06854985605471e-61 | 0.872761628066139 | 2.30156986410081e-59 | 0.868004148215815 | 0.00152283724088906 | 0.227864936281324 |
| CER | 2.57844685255226e-39 | 0.829761102596108 | 2.49834475635009e-47 | 0.870113022149859 | 4.27650258297503e-05 | 0.327584978156496 |
| TCX | 2.2855109195833e-54 | 0.897103265854963 | 4.04433554664134e-19 | 0.646515289864625 | 0.000240998059571024 | 0.295535738733925 |
| FP | 7.08004164752725e-45 | 0.821885224885361 | 1.51436181803897e-27 | 0.700160210973402 | 1.87089638912353e-10 | 0.45442865191501 |
| IFG | 3.35988449777802e-09 | 0.887458401202186 | 1.1314156000029e-07 | 0.844228346713682 | 0.230205192895395 | 0.248909908230361 |
| PG | 5.53918501375475e-06 | 0.326170483521334 | 1.67978300383817e-09 | 0.423716879972898 | 0.227856467637561 | 0.088844762025394 |
| STG | 8.92492475758433e-22 | 0.822280547748582 | 1.49560500102278e-12 | 0.677344374616001 | 0.54290991507102 | 0.0673172093300284 |
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Relation with AD stages for UBA1 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| CER | ADediting_1501467 | chrX_47208835_+ | 0.0012238822817217 | -0.30713808090835 |
| CER | ADediting_1501488 | chrX_47208980_+ | 0.00118463667730859 | 0.307978126343217 |
| TCX | ADediting_1501429 | chrX_47205644_+ | 0.000407322034091432 | 0.337259325646681 |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 1.49603672830331e-06 | 0.443881557119418 |
| TCX | 2.09621604360891e-06 | 0.442046080878186 |
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RelatedDrugs for UBA1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for UBA1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| UBA1 | C0003886 | Arthrogryposis | 2 | GENOMICS_ENGLAND |
| UBA1 | C1844934 | Arthrogryposis multiplex congenita, distal, X-linked | 2 | CTD_human;ORPHANET;UNIPROT |
| UBA1 | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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