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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for SEC14L6 |
 Gene summary |
| Gene information | Gene symbol | SEC14L6 | Gene ID | 730005 |
| Gene name | SEC14 like lipid binding 6 | |
| Synonyms | - | |
| Cytomap | 22q12.2 | |
| Type of gene | protein-coding | |
| Description | putative SEC14-like protein 6SEC14-like 6 | |
| Modification date | 20200313 | |
| UniProtAcc | B5MCN3, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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RNA A-to-I events for SEC14L6 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_982174(30523384, -), ADediting_982175(30523385, -), ADediting_982176(30523447, -), ADediting_982177(30523451, -), ADediting_982178(30523493, -), ADediting_982179(30523540, -), ADediting_982180(30523631, -), ADediting_982181(30523637, -), ADediting_982182(30524438, -), ADediting_982183(30524441, -), ADediting_982184(30524452, -), ADediting_982185(30524461, -), ADediting_982186(30524465, -), ADediting_982187(30524472, -), ADediting_982188(30524487, -), ADediting_982189(30524504, -), ADediting_982190(30524513, -), ADediting_982191(30524514, -), ADediting_982192(30524549, -), ADediting_982193(30524554, -), ADediting_982194(30524555, -), ADediting_982195(30524627, -), ADediting_982196(30524628, -), ADediting_982197(30524632, -), ADediting_982198(30524649, -), ADediting_982199(30524650, -), ADediting_982200(30524656, -), ADediting_982201(30526630, -), ADediting_982202(30526986, -), ADediting_982203(30528180, -), ADediting_982204(30528259, -), ADediting_982205(30528358, -), ADediting_982206(30528393, -), ADediting_982207(30528513, -), ADediting_982208(30528516, -), ADediting_982209(30528526, -), ADediting_982210(30528544, -), ADediting_982211(30528562, -), ADediting_982212(30528564, -), ADediting_982213(30528622, -), ADediting_982214(30528623, -), ADediting_982215(30528637, -), ADediting_982216(30528666, -), ADediting_982217(30528674, -), ADediting_982218(30528688, -), ADediting_982219(30528697, -), ADediting_982220(30530167, -), ADediting_982221(30530227, -), ADediting_982222(30530230, -), ADediting_982223(30530310, -), ADediting_982224(30530327, -), ADediting_982225(30530328, -), ADediting_982226(30530368, -), ADediting_982227(30531468, -), ADediting_982228(30531481, -), ADediting_982229(30531508, -), ADediting_982230(30531641, -), ADediting_982231(30531693, -), ADediting_982232(30533344, -), ADediting_982233(30533355, -), ADediting_982234(30533356, -), ADediting_982235(30533409, -), ADediting_982236(30533421, -), ADediting_982237(30533438, -), ADediting_982238(30536135, -), ADediting_1570322(30524442, -), ADediting_1570323(30524473, -), ADediting_1570324(30524540, -), ADediting_1570325(30526647, -), ADediting_1570326(30528651, -), ADediting_1570327(30530168, -), ADediting_1570328(30530477, -), ADediting_1570329(30530594, -), |
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RNA editing positional annotations for SEC14L6 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_982174 | chr22_30523384_- | UTR3 |
| ADediting_982175 | chr22_30523385_- | UTR3 |
| ADediting_982176 | chr22_30523447_- | UTR3 |
| ADediting_982177 | chr22_30523451_- | UTR3 |
| ADediting_982178 | chr22_30523493_- | UTR3 |
| ADediting_982179 | chr22_30523540_- | UTR3 |
| ADediting_982180 | chr22_30523631_- | UTR3 |
| ADediting_982181 | chr22_30523637_- | UTR3 |
| ADediting_982182 | chr22_30524438_- | UTR3 |
| ADediting_982183 | chr22_30524441_- | UTR3 |
| ADediting_982184 | chr22_30524452_- | UTR3 |
| ADediting_982185 | chr22_30524461_- | UTR3 |
| ADediting_982186 | chr22_30524465_- | UTR3 |
| ADediting_982187 | chr22_30524472_- | UTR3 |
| ADediting_982188 | chr22_30524487_- | UTR3 |
| ADediting_982189 | chr22_30524504_- | UTR3 |
| ADediting_982190 | chr22_30524513_- | UTR3 |
| ADediting_982191 | chr22_30524514_- | UTR3 |
| ADediting_982192 | chr22_30524549_- | UTR3 |
| ADediting_982193 | chr22_30524554_- | UTR3 |
| ADediting_982194 | chr22_30524555_- | UTR3 |
| ADediting_982195 | chr22_30524627_- | UTR3 |
| ADediting_982196 | chr22_30524628_- | UTR3 |
| ADediting_982197 | chr22_30524632_- | UTR3 |
| ADediting_982198 | chr22_30524649_- | UTR3 |
| ADediting_982199 | chr22_30524650_- | UTR3 |
| ADediting_982200 | chr22_30524656_- | UTR3 |
| ADediting_982201 | chr22_30526630_- | intronic |
| ADediting_982202 | chr22_30526986_- | intronic |
| ADediting_982203 | chr22_30528180_- | intronic |
| ADediting_982204 | chr22_30528259_- | intronic |
| ADediting_982205 | chr22_30528358_- | intronic |
| ADediting_982206 | chr22_30528393_- | intronic |
| ADediting_982207 | chr22_30528513_- | intronic |
| ADediting_982208 | chr22_30528516_- | intronic |
| ADediting_982209 | chr22_30528526_- | intronic |
| ADediting_982210 | chr22_30528544_- | intronic |
| ADediting_982211 | chr22_30528562_- | intronic |
| ADediting_982212 | chr22_30528564_- | intronic |
| ADediting_982213 | chr22_30528622_- | intronic |
| ADediting_982214 | chr22_30528623_- | intronic |
| ADediting_982215 | chr22_30528637_- | intronic |
| ADediting_982216 | chr22_30528666_- | intronic |
| ADediting_982217 | chr22_30528674_- | intronic |
| ADediting_982218 | chr22_30528688_- | intronic |
| ADediting_982219 | chr22_30528697_- | intronic |
| ADediting_982220 | chr22_30530167_- | intronic |
| ADediting_982221 | chr22_30530227_- | intronic |
| ADediting_982222 | chr22_30530230_- | intronic |
| ADediting_982223 | chr22_30530310_- | intronic |
| ADediting_982224 | chr22_30530327_- | intronic |
| ADediting_982225 | chr22_30530328_- | intronic |
| ADediting_982226 | chr22_30530368_- | intronic |
| ADediting_982227 | chr22_30531468_- | intronic |
| ADediting_982228 | chr22_30531481_- | intronic |
| ADediting_982229 | chr22_30531508_- | intronic |
| ADediting_982230 | chr22_30531641_- | intronic |
| ADediting_982231 | chr22_30531693_- | intronic |
| ADediting_982232 | chr22_30533344_- | intronic |
| ADediting_982233 | chr22_30533355_- | intronic |
| ADediting_982234 | chr22_30533356_- | intronic |
| ADediting_982235 | chr22_30533409_- | intronic |
| ADediting_982236 | chr22_30533421_- | intronic |
| ADediting_982237 | chr22_30533438_- | intronic |
| ADediting_982238 | chr22_30536135_- | intronic |
| ADediting_1570322 | chr22_30524442_- | UTR3 |
| ADediting_1570323 | chr22_30524473_- | UTR3 |
| ADediting_1570324 | chr22_30524540_- | UTR3 |
| ADediting_1570325 | chr22_30526647_- | intronic |
| ADediting_1570326 | chr22_30528651_- | intronic |
| ADediting_1570327 | chr22_30530168_- | intronic |
| ADediting_1570328 | chr22_30530477_- | intronic |
| ADediting_1570329 | chr22_30530594_- | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_982174 | chr22_30523384_- | SINE | Alu | Name=AluSx1 |
| ADediting_982175 | chr22_30523385_- | SINE | Alu | Name=AluSx1 |
| ADediting_982176 | chr22_30523447_- | SINE | Alu | Name=AluSx1 |
| ADediting_982177 | chr22_30523451_- | SINE | Alu | Name=AluSx1 |
| ADediting_982178 | chr22_30523493_- | SINE | Alu | Name=AluSx1 |
| ADediting_982179 | chr22_30523540_- | SINE | Alu | Name=AluSx1 |
| ADediting_982180 | chr22_30523631_- | SINE | Alu | Name=AluSx1 |
| ADediting_982181 | chr22_30523637_- | SINE | Alu | Name=AluSx1 |
| ADediting_982182 | chr22_30524438_- | SINE | Alu | Name=AluSz |
| ADediting_982183 | chr22_30524441_- | SINE | Alu | Name=AluSz |
| ADediting_982184 | chr22_30524452_- | SINE | Alu | Name=AluSz |
| ADediting_982185 | chr22_30524461_- | SINE | Alu | Name=AluSz |
| ADediting_982186 | chr22_30524465_- | SINE | Alu | Name=AluSz |
| ADediting_982187 | chr22_30524472_- | SINE | Alu | Name=AluSz |
| ADediting_982188 | chr22_30524487_- | SINE | Alu | Name=AluSz |
| ADediting_982189 | chr22_30524504_- | SINE | Alu | Name=AluSz |
| ADediting_982190 | chr22_30524513_- | SINE | Alu | Name=AluSz |
| ADediting_982191 | chr22_30524514_- | SINE | Alu | Name=AluSz |
| ADediting_982192 | chr22_30524549_- | SINE | Alu | Name=AluSz |
| ADediting_982193 | chr22_30524554_- | SINE | Alu | Name=AluSz |
| ADediting_982194 | chr22_30524555_- | SINE | Alu | Name=AluSz |
| ADediting_982195 | chr22_30524627_- | SINE | Alu | Name=AluSz |
| ADediting_982196 | chr22_30524628_- | SINE | Alu | Name=AluSz |
| ADediting_982197 | chr22_30524632_- | SINE | Alu | Name=AluSz |
| ADediting_982198 | chr22_30524649_- | SINE | Alu | Name=AluSz |
| ADediting_982199 | chr22_30524650_- | SINE | Alu | Name=AluSz |
| ADediting_982200 | chr22_30524656_- | SINE | Alu | Name=AluSz |
| ADediting_982201 | chr22_30526630_- | SINE | Alu | Name=AluSx3 |
| ADediting_982202 | chr22_30526986_- | SINE | Alu | Name=AluJo |
| ADediting_982203 | chr22_30528180_- | SINE | Alu | Name=AluSg7 |
| ADediting_982204 | chr22_30528259_- | SINE | Alu | Name=AluSg7 |
| ADediting_982205 | chr22_30528358_- | SINE | Alu | Name=AluSg7 |
| ADediting_982206 | chr22_30528393_- | SINE | Alu | Name=AluSg7 |
| ADediting_982207 | chr22_30528513_- | SINE | Alu | Name=AluJo |
| ADediting_982208 | chr22_30528516_- | SINE | Alu | Name=AluJo |
| ADediting_982209 | chr22_30528526_- | SINE | Alu | Name=AluJo |
| ADediting_982210 | chr22_30528544_- | SINE | Alu | Name=AluJo |
| ADediting_982211 | chr22_30528562_- | SINE | Alu | Name=AluJo |
| ADediting_982212 | chr22_30528564_- | SINE | Alu | Name=AluJo |
| ADediting_982213 | chr22_30528622_- | SINE | Alu | Name=AluJo |
| ADediting_982214 | chr22_30528623_- | SINE | Alu | Name=AluJo |
| ADediting_982215 | chr22_30528637_- | SINE | Alu | Name=AluJo |
| ADediting_982216 | chr22_30528666_- | SINE | Alu | Name=AluJo |
| ADediting_982217 | chr22_30528674_- | SINE | Alu | Name=AluJo |
| ADediting_982218 | chr22_30528688_- | SINE | Alu | Name=AluJo |
| ADediting_982219 | chr22_30528697_- | SINE | Alu | Name=AluJo |
| ADediting_982220 | chr22_30530167_- | SINE | Alu | Name=AluSx1 |
| ADediting_982221 | chr22_30530227_- | SINE | Alu | Name=AluSx1 |
| ADediting_982222 | chr22_30530230_- | SINE | Alu | Name=AluSx1 |
| ADediting_982223 | chr22_30530310_- | SINE | Alu | Name=AluSx1 |
| ADediting_982224 | chr22_30530327_- | SINE | Alu | Name=AluSx1 |
| ADediting_982225 | chr22_30530328_- | SINE | Alu | Name=AluSx1 |
| ADediting_982226 | chr22_30530368_- | SINE | Alu | Name=AluSx1 |
| ADediting_982227 | chr22_30531468_- | SINE | Alu | Name=AluSp |
| ADediting_982228 | chr22_30531481_- | SINE | Alu | Name=AluSp |
| ADediting_982229 | chr22_30531508_- | SINE | Alu | Name=AluSp |
| ADediting_982230 | chr22_30531641_- | SINE | Alu | Name=AluSp |
| ADediting_982231 | chr22_30531693_- | SINE | Alu | Name=AluSp |
| ADediting_982232 | chr22_30533344_- | SINE | Alu | Name=AluSx |
| ADediting_982233 | chr22_30533355_- | SINE | Alu | Name=AluSx |
| ADediting_982234 | chr22_30533356_- | SINE | Alu | Name=AluSx |
| ADediting_982235 | chr22_30533409_- | SINE | Alu | Name=AluSx |
| ADediting_982236 | chr22_30533421_- | SINE | Alu | Name=AluSx |
| ADediting_982237 | chr22_30533438_- | SINE | Alu | Name=AluSx |
| ADediting_982238 | chr22_30536135_- | SINE | Alu | Name=AluJo |
| ADediting_1570322 | chr22_30524442_- | SINE | Alu | Name=AluSz |
| ADediting_1570323 | chr22_30524473_- | SINE | Alu | Name=AluSz |
| ADediting_1570324 | chr22_30524540_- | SINE | Alu | Name=AluSz |
| ADediting_1570325 | chr22_30526647_- | SINE | Alu | Name=AluSx3 |
| ADediting_1570326 | chr22_30528651_- | SINE | Alu | Name=AluJo |
| ADediting_1570327 | chr22_30530168_- | SINE | Alu | Name=AluSx1 |
| ADediting_1570328 | chr22_30530477_- | SINE | Alu | Name=AluJo |
| ADediting_1570329 | chr22_30530594_- | SINE | Alu | Name=AluJo |
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RNA A-to-I editing events in the alternative splicing sites for SEC14L6 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for SEC14L6 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for SEC14L6 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for SEC14L6 |
| RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. |
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| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1570322 | chr22_30524442_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-4638-5p | chr22 | 30524441 | 30524448 | 8mer-1a | 30524441 | 30524460 | 146 | -20.28 |
| ADediting_1570324 | chr22_30524540_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-3190-5p | chr22 | 30524535 | 30524541 | 7mer-m8 | 30524534 | 30524553 | 143 | -16.24 |
| ADediting_1570324 | chr22_30524540_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-548s | chr22 | 30524536 | 30524542 | 7mer-m8 | 30524535 | 30524557 | 145 | -11.19 |
| ADediting_982177 | chr22_30523451_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-10400-3p | chr22 | 30523447 | 30523453 | 7mer-m8 | 30523446 | 30523468 | 152 | -26.08 |
| ADediting_982177 | chr22_30523451_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-4674 | chr22 | 30523447 | 30523453 | 7mer-m8 | 30523446 | 30523466 | 140 | -21.44 |
| ADediting_982178 | chr22_30523493_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-6886-5p | chr22 | 30523492 | 30523498 | 7mer-m8 | 30523491 | 30523511 | 142 | -17.56 |
| ADediting_982180 | chr22_30523631_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-513a-5p | chr22 | 30523630 | 30523636 | 7mer-m8 | 30523629 | 30523646 | 144 | -17.77 |
| ADediting_982180 | chr22_30523631_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-638 | chr22 | 30523625 | 30523631 | 7mer-1a | 30523625 | 30523649 | 149 | -29.88 |
| ADediting_982182 | chr22_30524438_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-564 | chr22 | 30524433 | 30524439 | 7mer-1a | 30524433 | 30524451 | 143 | -18.31 |
| ADediting_982185 | chr22_30524461_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-4485-5p | chr22 | 30524459 | 30524465 | 7mer-1a | 30524459 | 30524474 | 146 | -22.32 |
| ADediting_982187 | chr22_30524472_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-3934-3p | chr22 | 30524471 | 30524477 | 7mer-m8 | 30524470 | 30524491 | 155 | -18.52 |
| ADediting_982187 | chr22_30524472_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-6854-5p | chr22 | 30524470 | 30524476 | 7mer-m8 | 30524469 | 30524492 | 146 | -24.24 |
| ADediting_982189 | chr22_30524504_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-1207-3p | chr22 | 30524504 | 30524510 | 7mer-m8 | 30524503 | 30524520 | 140 | -13.03 |
| ADediting_982189 | chr22_30524504_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-646 | chr22 | 30524502 | 30524508 | 7mer-m8 | 30524501 | 30524519 | 145 | -14.88 |
| ADediting_982191 | chr22_30524514_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-513b-5p | chr22 | 30524513 | 30524519 | 7mer-m8 | 30524512 | 30524533 | 171 | -24.24 |
| ADediting_982192 | chr22_30524549_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-153-5p | chr22 | 30524549 | 30524555 | 7mer-m8 | 30524548 | 30524569 | 147 | -9.3 |
| ADediting_982192 | chr22_30524549_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-3680-3p | chr22 | 30524544 | 30524551 | 8mer-1a | 30524544 | 30524566 | 140 | -12.71 |
| ADediting_982194 | chr22_30524555_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-30a-3p | chr22 | 30524551 | 30524558 | 8mer-1a | 30524551 | 30524573 | 153 | -11.88 |
| ADediting_982194 | chr22_30524555_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-30d-3p | chr22 | 30524551 | 30524558 | 8mer-1a | 30524551 | 30524573 | 153 | -12.34 |
| ADediting_982194 | chr22_30524555_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-30e-3p | chr22 | 30524551 | 30524558 | 8mer-1a | 30524551 | 30524573 | 153 | -11.88 |
| ADediting_982196 | chr22_30524628_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-4638-5p | chr22 | 30524626 | 30524632 | 7mer-m8 | 30524625 | 30524645 | 142 | -16.85 |
| ADediting_982197 | chr22_30524632_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-150-5p | chr22 | 30524632 | 30524638 | 7mer-m8 | 30524631 | 30524652 | 140 | -15.8 |
| ADediting_982197 | chr22_30524632_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-6778-3p | chr22 | 30524630 | 30524636 | 7mer-m8 | 30524629 | 30524649 | 143 | -13.97 |
| ADediting_982197 | chr22_30524632_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-6878-3p | chr22 | 30524627 | 30524634 | 8mer-1a | 30524627 | 30524647 | 142 | -14.14 |
| ADediting_982198 | chr22_30524649_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-8052 | chr22 | 30524644 | 30524650 | 7mer-1a | 30524644 | 30524662 | 140 | -24.05 |
| ADediting_982199 | chr22_30524650_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-513a-5p | chr22 | 30524649 | 30524655 | 7mer-m8 | 30524648 | 30524665 | 152 | -17.77 |
| ADediting_982199 | chr22_30524650_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-638 | chr22 | 30524644 | 30524650 | 7mer-1a | 30524644 | 30524668 | 147 | -30.81 |
| ADediting_982199 | chr22_30524650_- | ENSG00000214491.8 | ENST00000437871.1 | SEC14L6-202 | hsa-miR-513a-5p | chr22 | 30524649 | 30524655 | 7mer-m8 | 30524648 | 30524665 | 152 | -17.77 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1570323 | chr22_30524473_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-5000-5p | chr22 | 30524470 | 30524476 | 7mer-m8 | 30524469 | 30524491 | 154 | -20.4 |
| ADediting_1570324 | chr22_30524540_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-4735-5p | chr22 | 30524539 | 30524545 | 7mer-m8 | 30524538 | 30524559 | 140 | -5.39 |
| ADediting_1570324 | chr22_30524540_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-4794 | chr22 | 30524535 | 30524541 | 7mer-m8 | 30524534 | 30524555 | 140 | -12.3 |
| ADediting_1570324 | chr22_30524540_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-664a-5p | chr22 | 30524535 | 30524541 | 7mer-m8 | 30524534 | 30524557 | 141 | -13.02 |
| ADediting_982174 | chr22_30523384_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-193a-5p | chr22 | 30523379 | 30523385 | 7mer-m8 | 30523378 | 30523398 | 141 | -14.19 |
| ADediting_982174 | chr22_30523384_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-431-5p | chr22 | 30523381 | 30523387 | 7mer-m8 | 30523380 | 30523400 | 140 | -12.18 |
| ADediting_982175 | chr22_30523385_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-431-5p | chr22 | 30523381 | 30523387 | 7mer-m8 | 30523380 | 30523400 | 140 | -12.18 |
| ADediting_982175 | chr22_30523385_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-5691 | chr22 | 30523384 | 30523391 | 8mer-1a | 30523384 | 30523404 | 147 | -18.96 |
| ADediting_982176 | chr22_30523447_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-6742-3p | chr22 | 30523444 | 30523451 | 8mer-1a | 30523444 | 30523463 | 145 | -17.55 |
| ADediting_982176 | chr22_30523447_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-6783-3p | chr22 | 30523444 | 30523450 | 7mer-m8 | 30523443 | 30523464 | 150 | -19.03 |
| ADediting_982177 | chr22_30523451_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-23a-5p | chr22 | 30523447 | 30523454 | 8mer-1a | 30523447 | 30523467 | 145 | -17.76 |
| ADediting_982177 | chr22_30523451_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-23b-5p | chr22 | 30523447 | 30523454 | 8mer-1a | 30523447 | 30523468 | 149 | -16.83 |
| ADediting_982177 | chr22_30523451_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-3692-3p | chr22 | 30523451 | 30523457 | 7mer-m8 | 30523450 | 30523477 | 151 | -24.05 |
| ADediting_982178 | chr22_30523493_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-1205 | chr22 | 30523492 | 30523498 | 7mer-m8 | 30523491 | 30523511 | 150 | -19.88 |
| ADediting_982178 | chr22_30523493_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-1288-3p | chr22 | 30523489 | 30523495 | 7mer-m8 | 30523488 | 30523508 | 140 | -14.73 |
| ADediting_982178 | chr22_30523493_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-3199 | chr22 | 30523487 | 30523494 | 8mer-1a | 30523487 | 30523509 | 145 | -18.98 |
| ADediting_982178 | chr22_30523493_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-509-3-5p | chr22 | 30523491 | 30523497 | 7mer-m8 | 30523490 | 30523512 | 151 | -19.24 |
| ADediting_982178 | chr22_30523493_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-6511b-5p | chr22 | 30523493 | 30523499 | 7mer-m8 | 30523492 | 30523515 | 145 | -23.42 |
| ADediting_982178 | chr22_30523493_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-6811-5p | chr22 | 30523493 | 30523499 | 7mer-m8 | 30523492 | 30523515 | 146 | -22.18 |
| ADediting_982178 | chr22_30523493_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-8052 | chr22 | 30523487 | 30523494 | 8mer-1a | 30523487 | 30523507 | 153 | -25.4 |
| ADediting_982179 | chr22_30523540_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-6832-5p | chr22 | 30523539 | 30523545 | 7mer-m8 | 30523538 | 30523560 | 142 | -14.59 |
| ADediting_982180 | chr22_30523631_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-10399-5p | chr22 | 30523629 | 30523635 | 7mer-m8 | 30523628 | 30523649 | 148 | -10 |
| ADediting_982180 | chr22_30523631_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-6504-3p | chr22 | 30523629 | 30523635 | 7mer-m8 | 30523628 | 30523649 | 149 | -15.11 |
| ADediting_982181 | chr22_30523637_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-3934-5p | chr22 | 30523633 | 30523639 | 7mer-m8 | 30523632 | 30523654 | 155 | -23.69 |
| ADediting_982181 | chr22_30523637_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-552-3p | chr22 | 30523631 | 30523638 | 8mer-1a | 30523631 | 30523651 | 140 | -14.09 |
| ADediting_982185 | chr22_30524461_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-5001-3p | chr22 | 30524459 | 30524465 | 7mer-m8 | 30524458 | 30524482 | 152 | -21.18 |
| ADediting_982187 | chr22_30524472_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-5000-5p | chr22 | 30524470 | 30524476 | 7mer-m8 | 30524469 | 30524491 | 154 | -20.4 |
| ADediting_982188 | chr22_30524487_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-1976 | chr22 | 30524482 | 30524489 | 8mer-1a | 30524482 | 30524502 | 149 | -21.37 |
| ADediting_982188 | chr22_30524487_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-6747-3p | chr22 | 30524484 | 30524491 | 8mer-1a | 30524484 | 30524505 | 150 | -24.11 |
| ADediting_982189 | chr22_30524504_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-562 | chr22 | 30524501 | 30524507 | 7mer-m8 | 30524500 | 30524517 | 154 | -12.74 |
| ADediting_982189 | chr22_30524504_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-5697 | chr22 | 30524500 | 30524506 | 7mer-m8 | 30524499 | 30524521 | 154 | -14.88 |
| ADediting_982198 | chr22_30524649_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-10399-5p | chr22 | 30524648 | 30524654 | 7mer-m8 | 30524647 | 30524668 | 148 | -10.26 |
| ADediting_982198 | chr22_30524649_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-5089-5p | chr22 | 30524644 | 30524650 | 7mer-m8 | 30524643 | 30524662 | 150 | -12.66 |
| ADediting_982198 | chr22_30524649_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-6504-3p | chr22 | 30524648 | 30524654 | 7mer-m8 | 30524647 | 30524668 | 148 | -14.48 |
| ADediting_982198 | chr22_30524649_- | ENSG00000214491.8 | ENST00000437871.1 | SEC14L6-202 | hsa-miR-10399-5p | chr22 | 30524648 | 30524654 | 7mer-m8 | 30524647 | 30524668 | 148 | -10.26 |
| ADediting_982198 | chr22_30524649_- | ENSG00000214491.8 | ENST00000437871.1 | SEC14L6-202 | hsa-miR-6504-3p | chr22 | 30524648 | 30524654 | 7mer-m8 | 30524647 | 30524668 | 148 | -14.48 |
| ADediting_982199 | chr22_30524650_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-10399-5p | chr22 | 30524648 | 30524654 | 7mer-m8 | 30524647 | 30524668 | 148 | -10.26 |
| ADediting_982199 | chr22_30524650_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-6504-3p | chr22 | 30524648 | 30524654 | 7mer-m8 | 30524647 | 30524668 | 148 | -14.48 |
| ADediting_982199 | chr22_30524650_- | ENSG00000214491.8 | ENST00000437871.1 | SEC14L6-202 | hsa-miR-10399-5p | chr22 | 30524648 | 30524654 | 7mer-m8 | 30524647 | 30524668 | 148 | -10.26 |
| ADediting_982199 | chr22_30524650_- | ENSG00000214491.8 | ENST00000437871.1 | SEC14L6-202 | hsa-miR-6504-3p | chr22 | 30524648 | 30524654 | 7mer-m8 | 30524647 | 30524668 | 148 | -14.48 |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1337757 | chr7_5495852_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-589-3p | chr22 | 30523810 | 30523817 | 8mer-1a | 30523810 | 30523836 | 150 | -19.13 |
| ADediting_1471004 | chr9_63819627_+ | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-4477b | chr22 | 30523165 | 30523171 | 7mer-m8 | 30523164 | 30523186 | 151 | -15.35 |
| ADediting_1471004 | chr9_63819627_+ | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-4477b | chr22 | 30523836 | 30523842 | 7mer-m8 | 30523835 | 30523856 | 153 | -13.09 |
| ADediting_1535951 | chr14_100874558_+ | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-337-3p | chr22 | 30523147 | 30523154 | 8mer-1a | 30523147 | 30523168 | 141 | -9.04 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_496066 | chr15_66496985_- | ENSG00000214491.8 | ENST00000402034.6 | SEC14L6-201 | hsa-miR-4512 | chr22 | 30523906 | 30523912 | 7mer-m8 | 30523905 | 30523926 | 146 | -15.87 |
| Differentially expressed gene-miRNA network |
| Differentially expressed mRNA-miRNA network |
 |
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The effects of the RNA editing to the stability of the RNA structures for SEC14L6 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000402034.6 | protein_coding |  |  |
| ENST00000437871.1 | protein_coding |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_982174 | ENST00000402034.6 | chr22_30523384_- | 2807 | -1177.80 | -1172.00 | -1202.20 |
| ADediting_982175 | ENST00000402034.6 | chr22_30523385_- | 2806 | -1174.10 | -1172.00 | -1202.20 |
| ADediting_982176 | ENST00000402034.6 | chr22_30523447_- | 2744 | -1171.30 | -1172.00 | -1202.20 |
| ADediting_982177 | ENST00000402034.6 | chr22_30523451_- | 2740 | -1172.80 | -1172.00 | -1202.20 |
| ADediting_982178 | ENST00000402034.6 | chr22_30523493_- | 2698 | -1173.80 | -1172.00 | -1202.20 |
| ADediting_982179 | ENST00000402034.6 | chr22_30523540_- | 2651 | -1171.00 | -1172.00 | -1202.20 |
| ADediting_982180 | ENST00000402034.6 | chr22_30523631_- | 2560 | -1173.90 | -1172.00 | -1202.20 |
| ADediting_982181 | ENST00000402034.6 | chr22_30523637_- | 2554 | -1173.60 | -1172.00 | -1202.20 |
| ADediting_982182 | ENST00000402034.6 | chr22_30524438_- | 1753 | -1175.40 | -1172.00 | -1202.20 |
| ADediting_982183 | ENST00000402034.6 | chr22_30524441_- | 1750 | -1172.00 | -1172.00 | -1202.20 |
| ADediting_1570322 | ENST00000402034.6 | chr22_30524442_- | 1749 | -1172.00 | -1172.00 | -1202.20 |
| ADediting_982184 | ENST00000402034.6 | chr22_30524452_- | 1739 | -1171.30 | -1172.00 | -1202.20 |
| ADediting_982185 | ENST00000402034.6 | chr22_30524461_- | 1730 | -1174.90 | -1172.00 | -1202.20 |
| ADediting_982186 | ENST00000402034.6 | chr22_30524465_- | 1726 | -1171.70 | -1172.00 | -1202.20 |
| ADediting_982187 | ENST00000402034.6 | chr22_30524472_- | 1719 | -1173.70 | -1172.00 | -1202.20 |
| ADediting_1570323 | ENST00000402034.6 | chr22_30524473_- | 1718 | -1174.00 | -1172.00 | -1202.20 |
| ADediting_982188 | ENST00000402034.6 | chr22_30524487_- | 1704 | -1171.90 | -1172.00 | -1202.20 |
| ADediting_982189 | ENST00000402034.6 | chr22_30524504_- | 1687 | -1172.90 | -1172.00 | -1202.20 |
| ADediting_982190 | ENST00000402034.6 | chr22_30524513_- | 1678 | -1173.90 | -1172.00 | -1202.20 |
| ADediting_982191 | ENST00000402034.6 | chr22_30524514_- | 1677 | -1172.00 | -1172.00 | -1202.20 |
| ADediting_1570324 | ENST00000402034.6 | chr22_30524540_- | 1651 | -1177.80 | -1172.00 | -1202.20 |
| ADediting_982192 | ENST00000402034.6 | chr22_30524549_- | 1642 | -1172.20 | -1172.00 | -1202.20 |
| ADediting_982193 | ENST00000402034.6 | chr22_30524554_- | 1637 | -1172.30 | -1172.00 | -1202.20 |
| ADediting_982194 | ENST00000402034.6 | chr22_30524555_- | 1636 | -1172.80 | -1172.00 | -1202.20 |
| ADediting_982195 | ENST00000402034.6 | chr22_30524627_- | 1564 | -1174.20 | -1172.00 | -1202.20 |
| ADediting_982196 | ENST00000402034.6 | chr22_30524628_- | 1563 | -1172.20 | -1172.00 | -1202.20 |
| ADediting_982197 | ENST00000402034.6 | chr22_30524632_- | 1559 | -1173.90 | -1172.00 | -1202.20 |
| ADediting_982198 | ENST00000402034.6 | chr22_30524649_- | 1542 | -1172.00 | -1172.00 | -1202.20 |
| ADediting_982199 | ENST00000402034.6 | chr22_30524650_- | 1541 | -1176.20 | -1172.00 | -1202.20 |
| ADediting_982200 | ENST00000402034.6 | chr22_30524656_- | 1535 | -1176.20 | -1172.00 | -1202.20 |
| ADediting_982198 | ENST00000437871.1 | chr22_30524649_- | 785 | -267.80 | -264.70 | -269.70 |
| ADediting_982199 | ENST00000437871.1 | chr22_30524650_- | 784 | -266.90 | -264.70 | -269.70 |
| ADediting_982200 | ENST00000437871.1 | chr22_30524656_- | 778 | -266.40 | -264.70 | -269.70 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for SEC14L6 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | ADediting_982181 | chr22_30523637_- | 0.0259218091230322 | 0.126509124674997 | 0.648024392338744 | 0.0260286941188397 | 9.90816036080441e-09 | 0.318349250592554 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 1.91497957502882e-24 | 0.535907182066651 | 1.04118203744252e-16 | 0.448000953385359 | 4.92175027562461e-23 | 0.521665179819277 |
| AC | 5.47032196717112e-27 | 0.611103576854717 | 1.91718877475508e-13 | 0.443056876282668 | 3.26837432612178e-31 | 0.64841288633781 |
| PCC | 2.45002871726885e-14 | 0.515131201963286 | 3.25381422433842e-09 | 0.411781558682019 | 3.42488039894355e-07 | 0.358900000124841 |
| CER | 4.5917339142271e-12 | 0.526346467906218 | 7.45413193443598e-07 | 0.391149699188916 | 7.13573471199077e-06 | 0.357383466486125 |
| FP | 1.32996641446202e-05 | 0.320056523542135 | 0.0146892179282254 | 0.182628041190625 | 3.89530414829921e-07 | 0.369378452304674 |
| IFG | 0.120148914736363 | 0.318976490677967 | 0.0301171099715033 | 0.434166959394361 | 0.729193062534271 | 0.0728787783716102 |
| PG | 1.24727531921548e-10 | 0.449352313427679 | 0.000123519169873032 | 0.277803318238051 | 0.000263758594963813 | 0.26452421434934 |
| STG | 4.23466265408064e-05 | 0.431147902365577 | 0.0327198413535324 | 0.233273099250589 | 1.8447294712441e-05 | 0.44890524328884 |
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Relation with AD stages for SEC14L6 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
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RelatedDrugs for SEC14L6 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SEC14L6 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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