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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited versus non-edited samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with AD stages

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene


Gene summary for TOP2B

check button Gene summary
Gene informationGene symbol

TOP2B

Gene ID

7155

Gene nameDNA topoisomerase II beta
SynonymsTOPIIB|top2beta
Cytomap

3p24.2

Type of geneprotein-coding
DescriptionDNA topoisomerase 2-betaDNA topoisomerase II, 180 kDDNA topoisomerase II, beta isozymeU937 associated antigenantigen MLAA-44topo II betatopoisomerase (DNA) II beta 180kDatopoisomerase II betatopoisomerase IIb
Modification date20200313
UniProtAcc

Q02880,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
TOP2B

GO:0006265

DNA topological change

10684600


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RNA A-to-I events for TOP2B

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_1057077(25601361, -), ADediting_1057078(25601393, -), ADediting_1057079(25601402, -), ADediting_1057080(25601427, -), ADediting_1057081(25601434, -), ADediting_1057082(25601439, -), ADediting_1057083(25601453, -), ADediting_1057084(25601456, -), ADediting_1057085(25601462, -), ADediting_1057086(25601471, -), ADediting_1057087(25601507, -), ADediting_1057088(25601510, -), ADediting_1057089(25601511, -), ADediting_1057090(25601519, -), ADediting_1057091(25601536, -), ADediting_1057092(25601561, -), ADediting_1057093(25601585, -), ADediting_1057094(25601607, -), ADediting_1057095(25602131, -), ADediting_1057096(25602151, -), ADediting_1057097(25602152, -), ADediting_1057098(25602213, -), ADediting_1057099(25602216, -), ADediting_1057100(25602230, -), ADediting_1057101(25602233, -), ADediting_1057102(25602239, -), ADediting_1057103(25602248, -), ADediting_1057104(25602249, -), ADediting_1057105(25602285, -), ADediting_1057106(25602288, -), ADediting_1057107(25602289, -), ADediting_1057108(25602314, -), ADediting_1057109(25602356, -), ADediting_1057110(25602359, -), ADediting_1057111(25602366, -), ADediting_1057112(25602391, -), ADediting_1057113(25603261, -), ADediting_1057114(25603286, -), ADediting_1057115(25603296, -), ADediting_1057116(25603299, -), ADediting_1057117(25603311, -), ADediting_1057118(25603347, -), ADediting_1057119(25603350, -), ADediting_1057120(25603359, -), ADediting_1057121(25603363, -), ADediting_1057122(25603367, -), ADediting_1057123(25603377, -), ADediting_1057124(25603407, -), ADediting_1057125(25603411, -), ADediting_1057126(25603419, -), ADediting_1057127(25603421, -), ADediting_1057128(25603422, -), ADediting_1057129(25603425, -), ADediting_1057130(25603436, -), ADediting_1057131(25603438, -), ADediting_1057132(25603439, -), ADediting_1057133(25603446, -), ADediting_1057134(25603456, -), ADediting_1057135(25603461, -), ADediting_1057136(25603462, -), ADediting_1057137(25603467, -), ADediting_1057138(25603469, -), ADediting_1057139(25603470, -), ADediting_1057140(25603475, -), ADediting_1057141(25603485, -), ADediting_1057142(25603489, -), ADediting_1057143(25603510, -), ADediting_1057144(25603515, -), ADediting_1057145(25603516, -), ADediting_1057146(25603522, -), ADediting_1057147(25603524, -), ADediting_1057148(25603532, -), ADediting_1057149(25621396, -), ADediting_1057150(25621414, -), ADediting_1057151(25621454, -), ADediting_1057152(25621459, -), ADediting_1057153(25621470, -), ADediting_1057154(25621499, -), ADediting_1057155(25621500, -), ADediting_1057156(25621556, -), ADediting_1057157(25621557, -), ADediting_1057158(25621580, -), ADediting_1057159(25621601, -), ADediting_1057160(25621631, -), ADediting_1057161(25621634, -), ADediting_1057162(25644444, -), ADediting_1057163(25644450, -), ADediting_1057164(25644509, -), ADediting_1057165(25644529, -), ADediting_1057166(25644573, -), ADediting_1057167(25644579, -), ADediting_1057168(25644589, -), ADediting_1057169(25644592, -), ADediting_1057170(25644593, -), ADediting_1057171(25644601, -), ADediting_1057172(25644654, -), ADediting_1057173(25644660, -), ADediting_1057174(25644857, -), ADediting_1057175(25644920, -), ADediting_1057176(25644924, -), ADediting_1057177(25644928, -), ADediting_1057178(25644934, -), ADediting_1057179(25645005, -), ADediting_1057180(25645044, -), ADediting_1057181(25645077, -), ADediting_1057182(25645089, -), ADediting_1057183(25646017, -), ADediting_1057184(25651636, -), ADediting_1057185(25651648, -), ADediting_1057186(25651802, -), ADediting_1057187(25651829, -), ADediting_1057188(25653429, -), ADediting_1057189(25653497, -), ADediting_1057190(25653636, -), ADediting_1057191(25657872, -), ADediting_1057192(25661138, -), ADediting_1573666(25601495, -), ADediting_1573667(25601566, -), ADediting_1573668(25601575, -), ADediting_1573669(25602204, -), ADediting_1573670(25603335, -), ADediting_1573671(25603348, -), ADediting_1573672(25603354, -), ADediting_1573673(25603410, -), ADediting_1573674(25603412, -), ADediting_1573675(25603413, -), ADediting_1573676(25603416, -), ADediting_1573677(25603418, -), ADediting_1573678(25603420, -), ADediting_1573679(25603431, -), ADediting_1573680(25603437, -), ADediting_1573681(25603444, -), ADediting_1573682(25603507, -), ADediting_1647037(25601497, -), ADediting_1647038(25621490, -), ADediting_1647039(25621510, -), ADediting_1647040(25621526, -), ADediting_1647041(25621535, -), ADediting_1647042(25621554, -), ADediting_1647043(25621555, -), ADediting_1647044(25621809, -), ADediting_1647045(25621823, -), ADediting_1647046(25621840, -), ADediting_1647047(25621867, -), ADediting_1647048(25621877, -), ADediting_1647049(25621889, -), ADediting_1647050(25621906, -), ADediting_1647051(25621913, -), ADediting_1647052(25621926, -), ADediting_1647053(25621953, -), ADediting_1647054(25628470, -), ADediting_1647055(25651662, -), ADediting_1647056(25651743, -), ADediting_1647057(25653676, -),

Top

RNA editing positional annotations for TOP2B using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_1057077chr3_25601361_-intronic
ADediting_1057078chr3_25601393_-intronic
ADediting_1057079chr3_25601402_-intronic
ADediting_1057080chr3_25601427_-intronic
ADediting_1057081chr3_25601434_-intronic
ADediting_1057082chr3_25601439_-intronic
ADediting_1057083chr3_25601453_-intronic
ADediting_1057084chr3_25601456_-intronic
ADediting_1057085chr3_25601462_-intronic
ADediting_1057086chr3_25601471_-intronic
ADediting_1057087chr3_25601507_-intronic
ADediting_1057088chr3_25601510_-intronic
ADediting_1057089chr3_25601511_-intronic
ADediting_1057090chr3_25601519_-intronic
ADediting_1057091chr3_25601536_-intronic
ADediting_1057092chr3_25601561_-intronic
ADediting_1057093chr3_25601585_-intronic
ADediting_1057094chr3_25601607_-intronic
ADediting_1057095chr3_25602131_-intronic
ADediting_1057096chr3_25602151_-intronic
ADediting_1057097chr3_25602152_-intronic
ADediting_1057098chr3_25602213_-intronic
ADediting_1057099chr3_25602216_-intronic
ADediting_1057100chr3_25602230_-intronic
ADediting_1057101chr3_25602233_-intronic
ADediting_1057102chr3_25602239_-intronic
ADediting_1057103chr3_25602248_-intronic
ADediting_1057104chr3_25602249_-intronic
ADediting_1057105chr3_25602285_-intronic
ADediting_1057106chr3_25602288_-intronic
ADediting_1057107chr3_25602289_-intronic
ADediting_1057108chr3_25602314_-intronic
ADediting_1057109chr3_25602356_-intronic
ADediting_1057110chr3_25602359_-intronic
ADediting_1057111chr3_25602366_-intronic
ADediting_1057112chr3_25602391_-intronic
ADediting_1057113chr3_25603261_-intronic
ADediting_1057114chr3_25603286_-intronic
ADediting_1057115chr3_25603296_-intronic
ADediting_1057116chr3_25603299_-intronic
ADediting_1057117chr3_25603311_-intronic
ADediting_1057118chr3_25603347_-intronic
ADediting_1057119chr3_25603350_-intronic
ADediting_1057120chr3_25603359_-intronic
ADediting_1057121chr3_25603363_-intronic
ADediting_1057122chr3_25603367_-intronic
ADediting_1057123chr3_25603377_-intronic
ADediting_1057124chr3_25603407_-intronic
ADediting_1057125chr3_25603411_-intronic
ADediting_1057126chr3_25603419_-intronic
ADediting_1057127chr3_25603421_-intronic
ADediting_1057128chr3_25603422_-intronic
ADediting_1057129chr3_25603425_-intronic
ADediting_1057130chr3_25603436_-intronic
ADediting_1057131chr3_25603438_-intronic
ADediting_1057132chr3_25603439_-intronic
ADediting_1057133chr3_25603446_-intronic
ADediting_1057134chr3_25603456_-intronic
ADediting_1057135chr3_25603461_-intronic
ADediting_1057136chr3_25603462_-intronic
ADediting_1057137chr3_25603467_-intronic
ADediting_1057138chr3_25603469_-intronic
ADediting_1057139chr3_25603470_-intronic
ADediting_1057140chr3_25603475_-intronic
ADediting_1057141chr3_25603485_-intronic
ADediting_1057142chr3_25603489_-intronic
ADediting_1057143chr3_25603510_-intronic
ADediting_1057144chr3_25603515_-intronic
ADediting_1057145chr3_25603516_-intronic
ADediting_1057146chr3_25603522_-intronic
ADediting_1057147chr3_25603524_-intronic
ADediting_1057148chr3_25603532_-intronic
ADediting_1057149chr3_25621396_-intronic
ADediting_1057150chr3_25621414_-intronic
ADediting_1057151chr3_25621454_-intronic
ADediting_1057152chr3_25621459_-intronic
ADediting_1057153chr3_25621470_-intronic
ADediting_1057154chr3_25621499_-intronic
ADediting_1057155chr3_25621500_-intronic
ADediting_1057156chr3_25621556_-intronic
ADediting_1057157chr3_25621557_-intronic
ADediting_1057158chr3_25621580_-intronic
ADediting_1057159chr3_25621601_-intronic
ADediting_1057160chr3_25621631_-intronic
ADediting_1057161chr3_25621634_-intronic
ADediting_1057162chr3_25644444_-intronic
ADediting_1057163chr3_25644450_-intronic
ADediting_1057164chr3_25644509_-intronic
ADediting_1057165chr3_25644529_-intronic
ADediting_1057166chr3_25644573_-intronic
ADediting_1057167chr3_25644579_-intronic
ADediting_1057168chr3_25644589_-intronic
ADediting_1057169chr3_25644592_-intronic
ADediting_1057170chr3_25644593_-intronic
ADediting_1057171chr3_25644601_-intronic
ADediting_1057172chr3_25644654_-intronic
ADediting_1057173chr3_25644660_-intronic
ADediting_1057174chr3_25644857_-intronic
ADediting_1057175chr3_25644920_-intronic
ADediting_1057176chr3_25644924_-intronic
ADediting_1057177chr3_25644928_-intronic
ADediting_1057178chr3_25644934_-intronic
ADediting_1057179chr3_25645005_-intronic
ADediting_1057180chr3_25645044_-intronic
ADediting_1057181chr3_25645077_-intronic
ADediting_1057182chr3_25645089_-intronic
ADediting_1057183chr3_25646017_-intronic
ADediting_1057184chr3_25651636_-intronic
ADediting_1057185chr3_25651648_-intronic
ADediting_1057186chr3_25651802_-intronic
ADediting_1057187chr3_25651829_-intronic
ADediting_1057188chr3_25653429_-intronic
ADediting_1057189chr3_25653497_-intronic
ADediting_1057190chr3_25653636_-intronic
ADediting_1057191chr3_25657872_-intronic
ADediting_1057192chr3_25661138_-intronic
ADediting_1573666chr3_25601495_-intronic
ADediting_1573667chr3_25601566_-intronic
ADediting_1573668chr3_25601575_-intronic
ADediting_1573669chr3_25602204_-intronic
ADediting_1573670chr3_25603335_-intronic
ADediting_1573671chr3_25603348_-intronic
ADediting_1573672chr3_25603354_-intronic
ADediting_1573673chr3_25603410_-intronic
ADediting_1573674chr3_25603412_-intronic
ADediting_1573675chr3_25603413_-intronic
ADediting_1573676chr3_25603416_-intronic
ADediting_1573677chr3_25603418_-intronic
ADediting_1573678chr3_25603420_-intronic
ADediting_1573679chr3_25603431_-intronic
ADediting_1573680chr3_25603437_-intronic
ADediting_1573681chr3_25603444_-intronic
ADediting_1573682chr3_25603507_-intronic
ADediting_1647037chr3_25601497_-intronic
ADediting_1647038chr3_25621490_-intronic
ADediting_1647039chr3_25621510_-intronic
ADediting_1647040chr3_25621526_-intronic
ADediting_1647041chr3_25621535_-intronic
ADediting_1647042chr3_25621554_-intronic
ADediting_1647043chr3_25621555_-intronic
ADediting_1647044chr3_25621809_-intronic
ADediting_1647045chr3_25621823_-intronic
ADediting_1647046chr3_25621840_-intronic
ADediting_1647047chr3_25621867_-intronic
ADediting_1647048chr3_25621877_-intronic
ADediting_1647049chr3_25621889_-intronic
ADediting_1647050chr3_25621906_-intronic
ADediting_1647051chr3_25621913_-intronic
ADediting_1647052chr3_25621926_-intronic
ADediting_1647053chr3_25621953_-intronic
ADediting_1647054chr3_25628470_-intronic
ADediting_1647055chr3_25651662_-intronic
ADediting_1647056chr3_25651743_-intronic
ADediting_1647057chr3_25653676_-intronic

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_1057077chr3_25601361_-SINEAluName=AluSq
ADediting_1057078chr3_25601393_-SINEAluName=AluSq
ADediting_1057079chr3_25601402_-SINEAluName=AluSq
ADediting_1057080chr3_25601427_-SINEAluName=AluSq
ADediting_1057081chr3_25601434_-SINEAluName=AluSq
ADediting_1057082chr3_25601439_-SINEAluName=AluSq
ADediting_1057083chr3_25601453_-SINEAluName=AluSq
ADediting_1057084chr3_25601456_-SINEAluName=AluSq
ADediting_1057085chr3_25601462_-SINEAluName=AluSq
ADediting_1057086chr3_25601471_-SINEAluName=AluSq
ADediting_1057087chr3_25601507_-SINEAluName=AluSq
ADediting_1057088chr3_25601510_-SINEAluName=AluSq
ADediting_1057089chr3_25601511_-SINEAluName=AluSq
ADediting_1057090chr3_25601519_-SINEAluName=AluSq
ADediting_1057091chr3_25601536_-SINEAluName=AluSq
ADediting_1057092chr3_25601561_-SINEAluName=AluSq
ADediting_1057093chr3_25601585_-SINEAluName=AluSq
ADediting_1057094chr3_25601607_-SINEAluName=AluSq
ADediting_1057095chr3_25602131_-SINEAluName=AluSx3
ADediting_1057096chr3_25602151_-SINEAluName=AluSx3
ADediting_1057097chr3_25602152_-SINEAluName=AluSx3
ADediting_1057098chr3_25602213_-SINEAluName=AluSx3
ADediting_1057099chr3_25602216_-SINEAluName=AluSx3
ADediting_1057100chr3_25602230_-SINEAluName=AluSx3
ADediting_1057101chr3_25602233_-SINEAluName=AluSx3
ADediting_1057102chr3_25602239_-SINEAluName=AluSx3
ADediting_1057103chr3_25602248_-SINEAluName=AluSx3
ADediting_1057104chr3_25602249_-SINEAluName=AluSx3
ADediting_1057105chr3_25602285_-SINEAluName=AluSx3
ADediting_1057106chr3_25602288_-SINEAluName=AluSx3
ADediting_1057107chr3_25602289_-SINEAluName=AluSx3
ADediting_1057108chr3_25602314_-SINEAluName=AluSx3
ADediting_1057109chr3_25602356_-SINEAluName=AluSx3
ADediting_1057110chr3_25602359_-SINEAluName=AluSx3
ADediting_1057111chr3_25602366_-SINEAluName=AluSx3
ADediting_1057112chr3_25602391_-SINEAluName=AluSx3
ADediting_1057113chr3_25603261_-SINEAluName=AluSz6
ADediting_1057114chr3_25603286_-SINEAluName=AluSz6
ADediting_1057115chr3_25603296_-SINEAluName=AluSz6
ADediting_1057116chr3_25603299_-SINEAluName=AluSz6
ADediting_1057117chr3_25603311_-SINEAluName=AluSz6
ADediting_1057118chr3_25603347_-SINEAluName=AluSz6
ADediting_1057119chr3_25603350_-SINEAluName=AluSz6
ADediting_1057120chr3_25603359_-SINEAluName=AluSz6
ADediting_1057121chr3_25603363_-SINEAluName=AluSz6
ADediting_1057122chr3_25603367_-SINEAluName=AluSz6
ADediting_1057123chr3_25603377_-SINEAluName=AluSz6
ADediting_1057124chr3_25603407_-SINEAluName=AluSz6
ADediting_1057125chr3_25603411_-SINEAluName=AluSz6
ADediting_1057126chr3_25603419_-SINEAluName=AluSz6
ADediting_1057127chr3_25603421_-SINEAluName=AluSz6
ADediting_1057128chr3_25603422_-SINEAluName=AluSz6
ADediting_1057129chr3_25603425_-SINEAluName=AluSz6
ADediting_1057130chr3_25603436_-SINEAluName=AluSz6
ADediting_1057131chr3_25603438_-SINEAluName=AluSz6
ADediting_1057132chr3_25603439_-SINEAluName=AluSz6
ADediting_1057133chr3_25603446_-SINEAluName=AluSz6
ADediting_1057134chr3_25603456_-SINEAluName=AluSz6
ADediting_1057135chr3_25603461_-SINEAluName=AluSz6
ADediting_1057136chr3_25603462_-SINEAluName=AluSz6
ADediting_1057137chr3_25603467_-SINEAluName=AluSz6
ADediting_1057138chr3_25603469_-SINEAluName=AluSz6
ADediting_1057139chr3_25603470_-SINEAluName=AluSz6
ADediting_1057140chr3_25603475_-SINEAluName=AluSz6
ADediting_1057141chr3_25603485_-SINEAluName=AluSz6
ADediting_1057142chr3_25603489_-SINEAluName=AluSz6
ADediting_1057143chr3_25603510_-SINEAluName=AluSz6
ADediting_1057144chr3_25603515_-SINEAluName=AluSz6
ADediting_1057145chr3_25603516_-SINEAluName=AluSz6
ADediting_1057146chr3_25603522_-SINEAluName=AluSz6
ADediting_1057147chr3_25603524_-SINEAluName=AluSz6
ADediting_1057148chr3_25603532_-SINEAluName=AluSz6
ADediting_1057149chr3_25621396_-SINEAluName=AluJb
ADediting_1057150chr3_25621414_-SINEAluName=AluJb
ADediting_1057151chr3_25621454_-SINEAluName=AluJb
ADediting_1057152chr3_25621459_-SINEAluName=AluJb
ADediting_1057153chr3_25621470_-SINEAluName=AluJb
ADediting_1057154chr3_25621499_-SINEAluName=AluJb
ADediting_1057155chr3_25621500_-SINEAluName=AluJb
ADediting_1057156chr3_25621556_-SINEAluName=AluJb
ADediting_1057157chr3_25621557_-SINEAluName=AluJb
ADediting_1057158chr3_25621580_-SINEAluName=AluJb
ADediting_1057159chr3_25621601_-SINEAluName=AluJb
ADediting_1057160chr3_25621631_-SINEAluName=AluJb
ADediting_1057161chr3_25621634_-SINEAluName=AluJb
ADediting_1057162chr3_25644444_-SINEAluName=AluSx
ADediting_1057163chr3_25644450_-SINEAluName=AluSx
ADediting_1057164chr3_25644509_-SINEAluName=AluSx
ADediting_1057165chr3_25644529_-SINEAluName=AluSx
ADediting_1057166chr3_25644573_-SINEAluName=AluSx
ADediting_1057167chr3_25644579_-SINEAluName=AluSx
ADediting_1057168chr3_25644589_-SINEAluName=AluSx
ADediting_1057169chr3_25644592_-SINEAluName=AluSx
ADediting_1057170chr3_25644593_-SINEAluName=AluSx
ADediting_1057171chr3_25644601_-SINEAluName=AluSx
ADediting_1057172chr3_25644654_-SINEAluName=AluSx
ADediting_1057173chr3_25644660_-SINEAluName=AluSx
ADediting_1057174chr3_25644857_-SINEAluName=AluY
ADediting_1057175chr3_25644920_-SINEAluName=AluY
ADediting_1057176chr3_25644924_-SINEAluName=AluY
ADediting_1057177chr3_25644928_-SINEAluName=AluY
ADediting_1057178chr3_25644934_-SINEAluName=AluY
ADediting_1057179chr3_25645005_-SINEAluName=AluY
ADediting_1057180chr3_25645044_-SINEAluName=AluY
ADediting_1057181chr3_25645077_-SINEAluName=AluY
ADediting_1057182chr3_25645089_-SINEAluName=AluY
ADediting_1057183chr3_25646017_-SINEAluName=AluSx
ADediting_1057184chr3_25651636_-SINEAluName=AluSx1
ADediting_1057185chr3_25651648_-SINEAluName=AluSx1
ADediting_1057186chr3_25651802_-SINEAluName=AluSx1
ADediting_1057187chr3_25651829_-SINEAluName=AluSx1
ADediting_1057188chr3_25653429_-SINEAluName=AluJb
ADediting_1057189chr3_25653497_-SINEAluName=AluJb
ADediting_1057190chr3_25653636_-SINEAluName=AluJb
ADediting_1057191chr3_25657872_-SINEAluName=AluYa5
ADediting_1057192chr3_25661138_-SINEAluName=AluSp
ADediting_1573666chr3_25601495_-SINEAluName=AluSq
ADediting_1573667chr3_25601566_-SINEAluName=AluSq
ADediting_1573668chr3_25601575_-SINEAluName=AluSq
ADediting_1573669chr3_25602204_-SINEAluName=AluSx3
ADediting_1573670chr3_25603335_-SINEAluName=AluSz6
ADediting_1573671chr3_25603348_-SINEAluName=AluSz6
ADediting_1573672chr3_25603354_-SINEAluName=AluSz6
ADediting_1573673chr3_25603410_-SINEAluName=AluSz6
ADediting_1573674chr3_25603412_-SINEAluName=AluSz6
ADediting_1573675chr3_25603413_-SINEAluName=AluSz6
ADediting_1573676chr3_25603416_-SINEAluName=AluSz6
ADediting_1573677chr3_25603418_-SINEAluName=AluSz6
ADediting_1573678chr3_25603420_-SINEAluName=AluSz6
ADediting_1573679chr3_25603431_-SINEAluName=AluSz6
ADediting_1573680chr3_25603437_-SINEAluName=AluSz6
ADediting_1573681chr3_25603444_-SINEAluName=AluSz6
ADediting_1573682chr3_25603507_-SINEAluName=AluSz6
ADediting_1647037chr3_25601497_-SINEAluName=AluSq
ADediting_1647038chr3_25621490_-SINEAluName=AluJb
ADediting_1647039chr3_25621510_-SINEAluName=AluJb
ADediting_1647040chr3_25621526_-SINEAluName=AluJb
ADediting_1647041chr3_25621535_-SINEAluName=AluJb
ADediting_1647042chr3_25621554_-SINEAluName=AluJb
ADediting_1647043chr3_25621555_-SINEAluName=AluJb
ADediting_1647044chr3_25621809_-SINEAluName=AluSz
ADediting_1647045chr3_25621823_-SINEAluName=AluSz
ADediting_1647046chr3_25621840_-SINEAluName=AluSz
ADediting_1647047chr3_25621867_-SINEAluName=AluSz
ADediting_1647048chr3_25621877_-SINEAluName=AluSz
ADediting_1647049chr3_25621889_-SINEAluName=AluSz
ADediting_1647050chr3_25621906_-SINEAluName=AluSz
ADediting_1647051chr3_25621913_-SINEAluName=AluSz
ADediting_1647052chr3_25621926_-SINEAluName=AluSz
ADediting_1647053chr3_25621953_-SINEAluName=AluSz
ADediting_1647054chr3_25628470_-SINEAluName=AluJb
ADediting_1647055chr3_25651662_-SINEAluName=AluSx1
ADediting_1647056chr3_25651743_-SINEAluName=AluSx1
ADediting_1647057chr3_25653676_-SINEAluName=AluJb

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RNA A-to-I editing events in the alternative splicing sites for TOP2B

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for TOP2B

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
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check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
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check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
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ADeditome IDChrPositoingSkipped exonENSGENSTs

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Protein coding region RNA A-to-I editings for TOP2B

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for TOP2B


check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for TOP2B

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in miRNA.
ADeditom_IDENSTmir_IDEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in mRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in lncRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for TOP2B

check button Correlation between ADAR gene expression and RNA editing frequency
TissueADeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFCADediting_1057078chr3_25601393_-1.29106517112919e-050.24492903769930.01494054711374440.1381263014791791.69675009813276e-170.458207082710018
DLPFCADediting_1057080chr3_25601427_-2.73413704478414e-060.262732515199010.0005159406336367620.1960898438150371.28324688628514e-080.316031827617334
DLPFCADediting_1057081chr3_25601434_-0.002938139792387640.1683920376443110.08496639014898650.09799564993079069.49972900123509e-110.356992918104544
DLPFCADediting_1057082chr3_25601439_-1.92672229913478e-060.2665726972507830.0002216656833922730.2082821406748494.65108550747768e-090.325015075635248
CERADediting_1057083chr3_25601453_-0.0002431940381323790.2953575214624233.58843431516871e-050.3306429720387580.433448429493531-0.0644290199462303
DLPFCADediting_1057089chr3_25601511_-1.93641980791216e-070.2904203056576150.0006468437442920110.1927010392975471.5747492657814e-100.353038184002122
DLPFCADediting_1057093chr3_25601585_-9.33455961161086e-090.3188808346018872.02864109291348e-050.2394851725807485.74742206317671e-050.226428325191311
CERADediting_1057095chr3_25602131_-4.17087766541744e-060.3657616821199255.62932388131549e-060.3611122958271940.03417406495284010.173075496109864
CERADediting_1057097chr3_25602152_-7.57059026489447e-070.390930389070522.45000114401255e-050.3371858025144240.1025524988104730.133820685767564
DLPFCADediting_1057099chr3_25602216_-0.001034910700200280.1854702769070980.3451093458886970.05380079609897342.46030915713287e-100.349500716469048
CERADediting_1057099chr3_25602216_-1.04977904329186e-080.446186454465941.72481515879115e-080.4402579721731430.001303069463667080.260168745800917
CERADediting_1057100chr3_25602230_-7.24008712641615e-060.357153638756711.75099391211816e-050.342825150850750.0005461609815120740.278973958910431
CERADediting_1057101chr3_25602233_-2.66223279209709e-090.4620023762583815.74512628846574e-070.3948102988001850.002212849531660440.248012804930334
CERADediting_1057102chr3_25602239_-3.68050958978843e-050.3302033193132473.99523563025424e-060.3664228607926470.0002095406185956550.298269351438764
CERADediting_1057106chr3_25602288_-1.18277143773112e-050.3492767450787812.9243040249504e-060.37117501676510.008766459109205770.213321566932352
CERADediting_1057107chr3_25602289_-1.47730245136135e-080.4421196279320427.60849725220527e-080.4218297452192560.002344111042992520.246654365341507
DLPFCADediting_1057109chr3_25602356_-1.29526689246495e-060.2708588253313970.0005387533227514660.195445741148193.68660650754001e-080.306363872428384
CERADediting_1057109chr3_25602356_-9.80667598706186e-060.3523088533099256.97144628277196e-060.3577518268474760.5875539400188370.0446367999524213
DLPFCADediting_1057110chr3_25602359_-1.14373893901883e-050.246367453989860.00629861489122890.1548454130918731.0809796556283e-090.337438654823629
DLPFCADediting_1057111chr3_25602366_-4.23455021819357e-070.2825474393983330.0004208909710592490.1990943057756915.00901640409539e-090.324368722714544
CERADediting_1057111chr3_25602366_-3.85812310777081e-050.3293836698707494.43649887747394e-050.3269405433241320.2651697150740810.0915532240420641
CERADediting_1057114chr3_25603286_-0.0002648313573387190.29367722647360.0001245544166609350.3082052690072850.657951014941980.036442732498868
CERADediting_1057115chr3_25603296_-3.20625312006524e-050.3325891191614871.28040980715445e-050.3479837617752960.02029333174893640.189365270421672
CERADediting_1057118chr3_25603347_-3.23038935849785e-060.3696672075441081.71280700245901e-060.3791502327172510.2946487392054770.0861284325180726
CERADediting_1057120chr3_25603359_-2.31689606520518e-080.4366800405026811.96034101733245e-070.4094762579431830.09222350448180350.137976231870734
DLPFCADediting_1057121chr3_25603363_-0.01816375515020810.1341027005816230.7339927884999710.01937689172443222.48358968971244e-080.310023375191684
CERADediting_1057121chr3_25603363_-3.07415851132e-090.4603812250285041.05334223459718e-080.4461463788842220.01766914645276190.193496400318611
CERADediting_1057123chr3_25603377_-9.70362482399837e-050.3128513674928110.0002250467850499290.2968774958310210.6196345227558820.0408531382145568
CERADediting_1057124chr3_25603407_-9.71797353174795e-080.4186828231392871.03440334687144e-080.4463609006420670.4493628064751920.0622268143420014
CERADediting_1057134chr3_25603456_-8.33262010354123e-050.315648851043820.0003620614050361220.2874223285984680.0589334033731963-0.154575789008548
DLPFCADediting_1057138chr3_25603469_-2.04189617647429e-050.2394057802607570.004126220339752770.1624836430617345.08726817275115e-090.324233386965369
CERADediting_1057142chr3_25603489_-0.0001279800584053240.3076956855350421.80616251473877e-050.342308906002250.6828625249683370.0336306882377294
DLPFCADediting_1057162chr3_25644444_-0.827035484508132-0.01246011714319510.0394924956837391-0.1170150526782834.56213206160871e-090.325183178463612
DLPFCADediting_1057163chr3_25644450_-0.0847578198890126-0.09806096350214820.00166039813103158-0.1779201433472619.093402388306e-100.338874638536795
DLPFCADediting_1057168chr3_25644589_-0.16367881773347-0.07930172628115030.00540454899017323-0.1576476999210014.75182444930794e-100.344200223404874
DLPFCADediting_1057169chr3_25644592_-0.492595879676206-0.03911584144047720.0280802842484676-0.1247499852513054.67067316668214e-120.37950224070837
DLPFCADediting_1057170chr3_25644593_-0.227456742628994-0.06874595798835410.0111761554925243-0.1439303814503014.24547532589156e-100.345114612451863
DLPFCADediting_1057175chr3_25644920_-0.396554603940763-0.04831833349072910.00867149703042972-0.1488452433760585.4510760575457e-090.323629538302119
DLPFCADediting_1057178chr3_25644934_-0.32872625804298-0.05565367370104120.00640628753257725-0.1545324018624871.75624579885701e-140.417147143373033
DLPFCADediting_1057181chr3_25645077_-0.309665999236085-0.05788600540072350.00139801798888043-0.1807010783883552.78786611007286e-130.399101566609226
DLPFCADediting_1057182chr3_25645089_-0.90677127483804-0.006678421523629760.0319531542873553-0.1218654833064421.86748809982148e-160.444640083378057

check button Correlation between ADAR gene expression and this gene's expression
TissueADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFC1.49170299122956e-630.7757905274522443.22700373017969e-620.770610486635640.2048622372980140.0722050061948932
AC3.73951270386766e-770.8674569003350827.12349136523319e-510.772755561668175.66468155484747e-160.482358319026888
PCC1.24283513787283e-310.7185614495882097.4526575611697e-310.7121246614163170.007464909826008970.19302535577705
CER4.07688178068153e-200.6599995666230666.56059592990005e-080.4237198633050890.6055159744905020.042507317868987
TCX2.98516973508957e-280.7490606712547912.52117091972918e-120.5317699217076390.09044930559581950.138726793496582
FP1.31819261793325e-220.648368117394612.8963873773954e-240.6669461034505030.2804484032021770.0813368187759117
IFG8.51181774586236e-050.7042933764612320.1009187959471240.3356689719991580.6192072103446130.104470641033611
PG3.16127663678973e-570.8658133808183846.95618155074932e-290.7015863393588980.9634207798549950.00338552880409191
STG8.91179693306575e-240.8428489380138662.7828387521389e-190.7923268783706090.998744124040958-0.00017435081065242

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Relation with AD stages for TOP2B

check button Correlation between AD stages and RNA editing frequency
TissueADeditomIDpositionP-valCoeff.
CERADediting_1057099chr3_25602216_-0.0004303620430130670.332937576076618
CERADediting_1057101chr3_25602233_-0.0005895631349916210.325404160821288
CERADediting_1057102chr3_25602239_-0.0004708014121200590.330807567515958
CERADediting_1057107chr3_25602289_-0.000700720337713350.321186678859931
CERADediting_1057115chr3_25603296_-0.0003470753023497190.33797742334958
CERADediting_1057121chr3_25603363_-0.000432447638966580.332823307200771

check button Correlation between AD stages and this gene's expression
TissueP-valCoeff.

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RelatedDrugs for TOP2B

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TOP2BQ02880DB00694DaunorubicinDNA topoisomerase 2-betasmall moleculeapproved
TOP2BQ02880DB00773EtoposideDNA topoisomerase 2-betasmall moleculeapproved
TOP2BQ02880DB00380DexrazoxaneDNA topoisomerase 2-betasmall moleculeapproved|withdrawn

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RelatedDiseases for TOP2B

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource
TOP2BC0023466Leukemia, Monocytic, Chronic1CTD_human
TOP2BC0023470Myeloid Leukemia1CTD_human
TOP2BC0282612Prostatic Intraepithelial Neoplasias1CTD_human