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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for TKT |
 Gene summary |
| Gene information | Gene symbol | TKT | Gene ID | 7086 |
| Gene name | transketolase | |
| Synonyms | HEL-S-48|HEL107|SDDHD|TK|TKT1 | |
| Cytomap | 3p21.1 | |
| Type of gene | protein-coding | |
| Description | transketolaseepididymis luminal protein 107epididymis secretory protein Li 48 | |
| Modification date | 20200313 | |
| UniProtAcc | P29401, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| TKT | GO:0046166 | glyceraldehyde-3-phosphate biosynthetic process | 9611778 |
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RNA A-to-I events for TKT |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_1083686(53237288, -), ADediting_1083687(53237302, -), ADediting_1083688(53237822, -), ADediting_1083689(53237842, -), ADediting_1083690(53239433, -), ADediting_1083691(53239437, -), ADediting_1083692(53239465, -), ADediting_1083693(53239469, -), ADediting_1083694(53239485, -), ADediting_1083695(53239488, -), ADediting_1083696(53239489, -), ADediting_1083697(53239491, -), ADediting_1083698(53239502, -), ADediting_1083699(53239515, -), ADediting_1083700(53239899, -), ADediting_1083701(53243200, -), ADediting_1083702(53246232, -), ADediting_1083703(53249333, -), ADediting_1083704(53249499, -), ADediting_1083705(53249500, -), ADediting_1083706(53250536, -), ADediting_1083707(53250568, -), ADediting_1083708(53250605, -), ADediting_1083709(53250663, -), ADediting_1083710(53250672, -), ADediting_1083711(53250688, -), ADediting_1083712(53250738, -), ADediting_1083713(53250741, -), ADediting_1083714(53250897, -), ADediting_1083715(53250920, -), ADediting_1083716(53250970, -), ADediting_1083717(53250974, -), ADediting_1083718(53250975, -), ADediting_1083719(53250983, -), ADediting_1083720(53250990, -), ADediting_1083721(53251022, -), ADediting_1083722(53251044, -), ADediting_1083723(53252018, -), ADediting_1083724(53252040, -), ADediting_1083725(53252057, -), ADediting_1083726(53252064, -), ADediting_1083727(53252922, -), ADediting_1083728(53252945, -), ADediting_1083729(53252951, -), ADediting_1083730(53252968, -), ADediting_1083731(53252977, -), ADediting_1083732(53252978, -), ADediting_1083733(53253004, -), ADediting_1083734(53253014, -), ADediting_1083735(53253034, -), ADediting_1083736(53253035, -), ADediting_1083737(53253044, -), ADediting_1083738(53253087, -), ADediting_1083739(53253137, -), ADediting_1083740(53253153, -), ADediting_1083741(53253400, -), ADediting_1083742(53253405, -), ADediting_1083743(53253418, -), ADediting_1083744(53253445, -), ADediting_1083745(53253541, -), ADediting_1083746(53253597, -), ADediting_1083747(53253599, -), ADediting_1083748(53253602, -), ADediting_1083749(53253617, -), ADediting_1083750(53253642, -), ADediting_1083751(53253664, -), ADediting_1083752(53253688, -), ADediting_1083753(53253701, -), ADediting_1083754(53253717, -), ADediting_1083755(53253720, -), ADediting_1083756(53253723, -), ADediting_1083757(53253829, -), ADediting_1083758(53253852, -), ADediting_1083759(53253853, -), ADediting_1083760(53253874, -), ADediting_1083761(53253875, -), ADediting_1575361(53237800, -), ADediting_1575362(53239424, -), ADediting_1575363(53253106, -), ADediting_1648185(53249095, -), ADediting_1648186(53249461, -), ADediting_1648187(53249471, -), |
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RNA editing positional annotations for TKT using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| ADediting_1575361 | chr3_53237800_- | nonsynonymous SNV | ENST00000423516.5 | c.A458G | p.Y153C | 0.178 | 0.926 | -0.18 |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_1083686 | chr3_53237288_- | intronic |
| ADediting_1083687 | chr3_53237302_- | intronic |
| ADediting_1083688 | chr3_53237822_- | splicing |
| ADediting_1083689 | chr3_53237842_- | UTR3 |
| ADediting_1083690 | chr3_53239433_- | intronic |
| ADediting_1083691 | chr3_53239437_- | intronic |
| ADediting_1083692 | chr3_53239465_- | intronic |
| ADediting_1083693 | chr3_53239469_- | intronic |
| ADediting_1083694 | chr3_53239485_- | intronic |
| ADediting_1083695 | chr3_53239488_- | intronic |
| ADediting_1083696 | chr3_53239489_- | intronic |
| ADediting_1083697 | chr3_53239491_- | intronic |
| ADediting_1083698 | chr3_53239502_- | intronic |
| ADediting_1083699 | chr3_53239515_- | intronic |
| ADediting_1083700 | chr3_53239899_- | intronic |
| ADediting_1083701 | chr3_53243200_- | intronic |
| ADediting_1083702 | chr3_53246232_- | intronic |
| ADediting_1083703 | chr3_53249333_- | intronic |
| ADediting_1083704 | chr3_53249499_- | intronic |
| ADediting_1083705 | chr3_53249500_- | intronic |
| ADediting_1083706 | chr3_53250536_- | intronic |
| ADediting_1083707 | chr3_53250568_- | intronic |
| ADediting_1083708 | chr3_53250605_- | intronic |
| ADediting_1083709 | chr3_53250663_- | intronic |
| ADediting_1083710 | chr3_53250672_- | intronic |
| ADediting_1083711 | chr3_53250688_- | intronic |
| ADediting_1083712 | chr3_53250738_- | intronic |
| ADediting_1083713 | chr3_53250741_- | intronic |
| ADediting_1083714 | chr3_53250897_- | intronic |
| ADediting_1083715 | chr3_53250920_- | intronic |
| ADediting_1083716 | chr3_53250970_- | intronic |
| ADediting_1083717 | chr3_53250974_- | intronic |
| ADediting_1083718 | chr3_53250975_- | intronic |
| ADediting_1083719 | chr3_53250983_- | intronic |
| ADediting_1083720 | chr3_53250990_- | intronic |
| ADediting_1083721 | chr3_53251022_- | intronic |
| ADediting_1083722 | chr3_53251044_- | intronic |
| ADediting_1083723 | chr3_53252018_- | intronic |
| ADediting_1083724 | chr3_53252040_- | intronic |
| ADediting_1083725 | chr3_53252057_- | intronic |
| ADediting_1083726 | chr3_53252064_- | intronic |
| ADediting_1083727 | chr3_53252922_- | intronic |
| ADediting_1083728 | chr3_53252945_- | intronic |
| ADediting_1083729 | chr3_53252951_- | intronic |
| ADediting_1083730 | chr3_53252968_- | intronic |
| ADediting_1083731 | chr3_53252977_- | intronic |
| ADediting_1083732 | chr3_53252978_- | intronic |
| ADediting_1083733 | chr3_53253004_- | intronic |
| ADediting_1083734 | chr3_53253014_- | intronic |
| ADediting_1083735 | chr3_53253034_- | intronic |
| ADediting_1083736 | chr3_53253035_- | intronic |
| ADediting_1083737 | chr3_53253044_- | intronic |
| ADediting_1083738 | chr3_53253087_- | intronic |
| ADediting_1083739 | chr3_53253137_- | intronic |
| ADediting_1083740 | chr3_53253153_- | intronic |
| ADediting_1083741 | chr3_53253400_- | intronic |
| ADediting_1083742 | chr3_53253405_- | intronic |
| ADediting_1083743 | chr3_53253418_- | intronic |
| ADediting_1083744 | chr3_53253445_- | intronic |
| ADediting_1083745 | chr3_53253541_- | intronic |
| ADediting_1083746 | chr3_53253597_- | intronic |
| ADediting_1083747 | chr3_53253599_- | intronic |
| ADediting_1083748 | chr3_53253602_- | intronic |
| ADediting_1083749 | chr3_53253617_- | intronic |
| ADediting_1083750 | chr3_53253642_- | intronic |
| ADediting_1083751 | chr3_53253664_- | intronic |
| ADediting_1083752 | chr3_53253688_- | intronic |
| ADediting_1083753 | chr3_53253701_- | intronic |
| ADediting_1083754 | chr3_53253717_- | intronic |
| ADediting_1083755 | chr3_53253720_- | intronic |
| ADediting_1083756 | chr3_53253723_- | intronic |
| ADediting_1083757 | chr3_53253829_- | intronic |
| ADediting_1083758 | chr3_53253852_- | intronic |
| ADediting_1083759 | chr3_53253853_- | intronic |
| ADediting_1083760 | chr3_53253874_- | intronic |
| ADediting_1083761 | chr3_53253875_- | intronic |
| ADediting_1575361 | chr3_53237800_- | exonic |
| ADediting_1575362 | chr3_53239424_- | intronic |
| ADediting_1575363 | chr3_53253106_- | intronic |
| ADediting_1648185 | chr3_53249095_- | intronic |
| ADediting_1648186 | chr3_53249461_- | intronic |
| ADediting_1648187 | chr3_53249471_- | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_1083686 | chr3_53237288_- | SINE | Alu | Name=AluSx |
| ADediting_1083687 | chr3_53237302_- | SINE | Alu | Name=AluSx |
| ADediting_1083688 | chr3_53237822_- | SINE | Alu | Name=AluSc8 |
| ADediting_1083689 | chr3_53237842_- | SINE | Alu | Name=AluSc8 |
| ADediting_1083690 | chr3_53239433_- | SINE | Alu | Name=AluJr |
| ADediting_1083691 | chr3_53239437_- | SINE | Alu | Name=AluJr |
| ADediting_1083692 | chr3_53239465_- | SINE | Alu | Name=AluJr |
| ADediting_1083693 | chr3_53239469_- | SINE | Alu | Name=AluJr |
| ADediting_1083694 | chr3_53239485_- | SINE | Alu | Name=AluJr |
| ADediting_1083695 | chr3_53239488_- | SINE | Alu | Name=AluJr |
| ADediting_1083696 | chr3_53239489_- | SINE | Alu | Name=AluJr |
| ADediting_1083697 | chr3_53239491_- | SINE | Alu | Name=AluJr |
| ADediting_1083698 | chr3_53239502_- | SINE | Alu | Name=AluJr |
| ADediting_1083699 | chr3_53239515_- | SINE | Alu | Name=AluJr |
| ADediting_1083702 | chr3_53246232_- | SINE | Alu | Name=AluSx1 |
| ADediting_1083703 | chr3_53249333_- | SINE | Alu | Name=AluSx |
| ADediting_1083704 | chr3_53249499_- | SINE | Alu | Name=AluSx |
| ADediting_1083705 | chr3_53249500_- | SINE | Alu | Name=AluSx |
| ADediting_1083706 | chr3_53250536_- | SINE | Alu | Name=AluJb |
| ADediting_1083707 | chr3_53250568_- | SINE | Alu | Name=AluJb |
| ADediting_1083708 | chr3_53250605_- | SINE | Alu | Name=AluJb |
| ADediting_1083709 | chr3_53250663_- | SINE | Alu | Name=AluJb |
| ADediting_1083710 | chr3_53250672_- | SINE | Alu | Name=AluJb |
| ADediting_1083711 | chr3_53250688_- | SINE | Alu | Name=AluJb |
| ADediting_1083712 | chr3_53250738_- | SINE | Alu | Name=AluJb |
| ADediting_1083713 | chr3_53250741_- | SINE | Alu | Name=AluJb |
| ADediting_1083714 | chr3_53250897_- | SINE | Alu | Name=AluJo |
| ADediting_1083715 | chr3_53250920_- | SINE | Alu | Name=AluJo |
| ADediting_1083716 | chr3_53250970_- | SINE | Alu | Name=AluJo |
| ADediting_1083717 | chr3_53250974_- | SINE | Alu | Name=AluJo |
| ADediting_1083718 | chr3_53250975_- | SINE | Alu | Name=AluJo |
| ADediting_1083719 | chr3_53250983_- | SINE | Alu | Name=AluJo |
| ADediting_1083720 | chr3_53250990_- | SINE | Alu | Name=AluJo |
| ADediting_1083721 | chr3_53251022_- | SINE | Alu | Name=AluJo |
| ADediting_1083722 | chr3_53251044_- | SINE | Alu | Name=AluJo |
| ADediting_1083723 | chr3_53252018_- | SINE | Alu | Name=AluSp |
| ADediting_1083724 | chr3_53252040_- | SINE | Alu | Name=AluSp |
| ADediting_1083725 | chr3_53252057_- | SINE | Alu | Name=AluSp |
| ADediting_1083726 | chr3_53252064_- | SINE | Alu | Name=AluSp |
| ADediting_1083727 | chr3_53252922_- | SINE | Alu | Name=AluSq2 |
| ADediting_1083728 | chr3_53252945_- | SINE | Alu | Name=AluSq2 |
| ADediting_1083729 | chr3_53252951_- | SINE | Alu | Name=AluSq2 |
| ADediting_1083730 | chr3_53252968_- | SINE | Alu | Name=AluSq2 |
| ADediting_1083731 | chr3_53252977_- | SINE | Alu | Name=AluSq2 |
| ADediting_1083732 | chr3_53252978_- | SINE | Alu | Name=AluSq2 |
| ADediting_1083733 | chr3_53253004_- | SINE | Alu | Name=AluSq2 |
| ADediting_1083734 | chr3_53253014_- | SINE | Alu | Name=AluSq2 |
| ADediting_1083735 | chr3_53253034_- | SINE | Alu | Name=AluSq2 |
| ADediting_1083736 | chr3_53253035_- | SINE | Alu | Name=AluSq2 |
| ADediting_1083737 | chr3_53253044_- | SINE | Alu | Name=AluSq2 |
| ADediting_1083738 | chr3_53253087_- | SINE | Alu | Name=AluSq2 |
| ADediting_1083739 | chr3_53253137_- | SINE | Alu | Name=AluSq2 |
| ADediting_1083740 | chr3_53253153_- | SINE | Alu | Name=AluJr |
| ADediting_1083741 | chr3_53253400_- | SINE | Alu | Name=AluJo |
| ADediting_1083742 | chr3_53253405_- | SINE | Alu | Name=AluJo |
| ADediting_1083743 | chr3_53253418_- | SINE | Alu | Name=AluJo |
| ADediting_1083744 | chr3_53253445_- | SINE | Alu | Name=AluJo |
| ADediting_1083745 | chr3_53253541_- | SINE | Alu | Name=AluSx1 |
| ADediting_1083746 | chr3_53253597_- | SINE | Alu | Name=AluSx1 |
| ADediting_1083747 | chr3_53253599_- | SINE | Alu | Name=AluSx1 |
| ADediting_1083748 | chr3_53253602_- | SINE | Alu | Name=AluSx1 |
| ADediting_1083749 | chr3_53253617_- | SINE | Alu | Name=AluSx1 |
| ADediting_1083750 | chr3_53253642_- | SINE | Alu | Name=AluSx1 |
| ADediting_1083751 | chr3_53253664_- | SINE | Alu | Name=AluSx1 |
| ADediting_1083752 | chr3_53253688_- | SINE | Alu | Name=AluSx1 |
| ADediting_1083753 | chr3_53253701_- | SINE | Alu | Name=AluSx1 |
| ADediting_1083754 | chr3_53253717_- | SINE | Alu | Name=AluSx1 |
| ADediting_1083755 | chr3_53253720_- | SINE | Alu | Name=AluSx1 |
| ADediting_1083756 | chr3_53253723_- | SINE | Alu | Name=AluSx1 |
| ADediting_1083757 | chr3_53253829_- | SINE | Alu | Name=AluJo |
| ADediting_1083758 | chr3_53253852_- | SINE | Alu | Name=AluJo |
| ADediting_1083759 | chr3_53253853_- | SINE | Alu | Name=AluJo |
| ADediting_1083760 | chr3_53253874_- | SINE | Alu | Name=AluJo |
| ADediting_1083761 | chr3_53253875_- | SINE | Alu | Name=AluJo |
| ADediting_1575361 | chr3_53237800_- | SINE | Alu | Name=AluSc8 |
| ADediting_1575362 | chr3_53239424_- | SINE | Alu | Name=AluJr |
| ADediting_1575363 | chr3_53253106_- | SINE | Alu | Name=AluSq2 |
| ADediting_1648185 | chr3_53249095_- | SINE | Alu | Name=AluSx1 |
| ADediting_1648186 | chr3_53249461_- | SINE | Alu | Name=AluSx |
| ADediting_1648187 | chr3_53249471_- | SINE | Alu | Name=AluSx |
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RNA A-to-I editing events in the alternative splicing sites for TKT |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| A3SS | ADediting_1083688 | chr3_53237822_- | 53237818:53237840 | 3ss | 2i | TGATTCTCCTCCTGCCTCAGCCT | 5.32 | TGATTCTCCTCCTGCCTCGGCCT | -2.64 |
| ES | ADediting_1083688 | chr3_53237822_- | 53237818:53237840 | 3ss | 2i | TGATTCTCCTCCTGCCTCAGCCT | 5.32 | TGATTCTCCTCCTGCCTCGGCCT | -2.64 |
| ES | ADediting_1083688 | chr3_53237822_- | 53237818:53237840 | 3ss | 2i | TGATTCTCCTCCTGCCTCAGCCT | 5.32 | TGATTCTCCTCCTGCCTCGGCCT | -2.64 |
| ES | ADediting_1083688 | chr3_53237822_- | 53237818:53237840 | 3ss | 2i | TGATTCTCCTCCTGCCTCAGCCT | 5.32 | TGATTCTCCTCCTGCCTCGGCCT | -2.64 |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for TKT |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for TKT |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for TKT |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1337757 | chr7_5495852_- | ENSG00000163931.16 | ENST00000423525.6 | TKT-203 | hsa-miR-589-3p | chr3 | 53224987 | 53224993 | 7mer-m8 | 53224986 | 53225009 | 146 | -15.34 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000163931.16 | ENST00000462138.6 | TKT-208 | hsa-miR-589-3p | chr3 | 53224987 | 53224993 | 7mer-m8 | 53224986 | 53225009 | 146 | -15.34 |
| ADediting_1391023 | chr8_140732605_- | ENSG00000163931.16 | ENST00000423525.6 | TKT-203 | hsa-miR-151a-3p | chr3 | 53225384 | 53225390 | 7mer-m8 | 53225383 | 53225404 | 154 | -21.46 |
| ADediting_1391023 | chr8_140732605_- | ENSG00000163931.16 | ENST00000462138.6 | TKT-208 | hsa-miR-151a-3p | chr3 | 53225384 | 53225390 | 7mer-m8 | 53225383 | 53225404 | 154 | -21.46 |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000163931.16 | ENST00000423525.6 | TKT-203 | hsa-miR-4477b | chr3 | 53225139 | 53225145 | 7mer-m8 | 53225138 | 53225160 | 155 | -17.88 |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000163931.16 | ENST00000462138.6 | TKT-208 | hsa-miR-4477b | chr3 | 53225139 | 53225145 | 7mer-m8 | 53225138 | 53225160 | 155 | -17.88 |
| ADediting_98289 | chr1_32086992_+ | ENSG00000163931.16 | ENST00000423525.6 | TKT-203 | hsa-miR-5585-3p | chr3 | 53225463 | 53225469 | 7mer-m8 | 53225462 | 53225484 | 151 | -14.58 |
| ADediting_98289 | chr1_32086992_+ | ENSG00000163931.16 | ENST00000462138.6 | TKT-208 | hsa-miR-5585-3p | chr3 | 53225463 | 53225469 | 7mer-m8 | 53225462 | 53225484 | 151 | -14.58 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for TKT |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000423516.5 | protein_coding |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_1575361 | ENST00000423516.5 | chr3_53237800_- | 538 | -819.20 | -819.50 | -819.20 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for TKT |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| CER | ADediting_1083690 | chr3_53239433_- | 0.000808035774007168 | 0.270668737351896 | 2.66280656081825e-09 | 0.46199995423338 | 0.187846304122341 | 0.108119693019664 |
| CER | ADediting_1083691 | chr3_53239437_- | 0.00573761052945263 | 0.224540776287608 | 2.22573163743812e-05 | 0.338808730382896 | 0.0448783086315676 | 0.164033502859784 |
| CER | ADediting_1083692 | chr3_53239465_- | 0.00538414327320128 | 0.226179166017453 | 3.18252721758163e-06 | 0.369893789727446 | 0.0675561450682255 | 0.149662220272294 |
| CER | ADediting_1083693 | chr3_53239469_- | 0.00680895331238283 | 0.22007320392401 | 3.25417430970638e-06 | 0.369555790978458 | 0.0401242802216392 | 0.167796832616839 |
| CER | ADediting_1083695 | chr3_53239488_- | 0.0097806347425068 | 0.210335390394034 | 4.9675490545889e-06 | 0.363060230526688 | 0.016975207901881 | 0.194677547450445 |
| CER | ADediting_1083697 | chr3_53239491_- | 0.00830703186059569 | 0.214776119582258 | 5.90882902444885e-05 | 0.321861979707147 | 0.187048407923878 | 0.108314263551599 |
| DLPFC | ADediting_1083739 | chr3_53253137_- | 0.772040782385589 | 0.0165198367838764 | 0.0694744575360929 | -0.103244748268412 | 7.95315642426715e-23 | 0.519501736341366 |
| DLPFC | ADediting_1083751 | chr3_53253664_- | 0.832236280646825 | -0.012079742006181 | 0.0151242850783762 | -0.137877420729224 | 1.02567170838309e-17 | 0.460979304598983 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 2.39213762358748e-50 | 0.717763623343541 | 1.47069793764968e-44 | 0.686660984626307 | 1.45686094985453e-18 | 0.471495750503118 |
| AC | 5.33634208471886e-33 | 0.66276624209656 | 2.95099896417042e-19 | 0.526835092434664 | 3.13349533975045e-20 | 0.538867030866698 |
| PCC | 1.52427722040657e-26 | 0.672945666537697 | 4.92101798491929e-26 | 0.667885577782941 | 0.000216244095001329 | 0.264617552097883 |
| CER | 2.2813083571701e-26 | 0.731267250343807 | 5.5944373055909e-30 | 0.764165040899212 | 6.97541547468395e-06 | 0.357742830860716 |
| TCX | 1.27579374895188e-14 | 0.575794258695866 | 0.00037165880595486 | 0.286892470583042 | 3.53821967025757e-05 | 0.330887231477158 |
| FP | 1.12532432374668e-14 | 0.536827428806893 | 3.52576346833046e-14 | 0.5282172041701 | 3.78081178977755e-06 | 0.338608632076041 |
| IFG | 2.01889840774392e-08 | 0.867285634998799 | 8.43899147827743e-07 | 0.81173458455445 | 0.028638151935594 | 0.437740266326109 |
| STG | 4.91846083037816e-14 | 0.708186519275599 | 2.58092044870899e-07 | 0.527159774522208 | 0.366578188816429 | 0.0997634014184658 |
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Relation with AD stages for TKT |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| CER | ADediting_1083690 | chr3_53239433_- | 0.001084812137387 | 0.310234903943938 |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 0.000905956713280049 | 0.314799719468554 |
| TCX | 5.88864746692861e-06 | 0.424100704138489 |
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RelatedDrugs for TKT |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TKT |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| TKT | C0001973 | Alcoholic Intoxication, Chronic | 2 | PSYGENET |
| TKT | C0003129 | Anoxemia | 1 | CTD_human |
| TKT | C0003130 | Anoxia | 1 | CTD_human |
| TKT | C0007097 | Carcinoma | 1 | CTD_human |
| TKT | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
| TKT | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
| TKT | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
| TKT | C0043121 | Wernicke Encephalopathy | 1 | CTD_human |
| TKT | C0205696 | Anaplastic carcinoma | 1 | CTD_human |
| TKT | C0205697 | Carcinoma, Spindle-Cell | 1 | CTD_human |
| TKT | C0205698 | Undifferentiated carcinoma | 1 | CTD_human |
| TKT | C0205699 | Carcinomatosis | 1 | CTD_human |
| TKT | C0242184 | Hypoxia | 1 | CTD_human |
| TKT | C0700292 | Hypoxemia | 1 | CTD_human |
| TKT | C1257925 | Mammary Carcinoma, Animal | 1 | CTD_human |
| TKT | C4310751 | SHORT STATURE, DEVELOPMENTAL DELAY, AND CONGENITAL HEART DEFECTS | 1 | ORPHANET;UNIPROT |
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