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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for TKT |
 Gene summary |
| Gene information | Gene symbol | TKT | Gene ID | 7086 |
| Gene name | transketolase | |
| Synonyms | HEL-S-48|HEL107|SDDHD|TK|TKT1 | |
| Cytomap | 3p21.1 | |
| Type of gene | protein-coding | |
| Description | transketolaseepididymis luminal protein 107epididymis secretory protein Li 48 | |
| Modification date | 20200313 | |
| UniProtAcc | P29401, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| TKT | GO:0046166 | glyceraldehyde-3-phosphate biosynthetic process | 9611778 |
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RNA A-to-I events for TKT |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_1083686(53237288, -), ADediting_1083687(53237302, -), ADediting_1083688(53237822, -), ADediting_1083689(53237842, -), ADediting_1083690(53239433, -), ADediting_1083691(53239437, -), ADediting_1083692(53239465, -), ADediting_1083693(53239469, -), ADediting_1083694(53239485, -), ADediting_1083695(53239488, -), ADediting_1083696(53239489, -), ADediting_1083697(53239491, -), ADediting_1083698(53239502, -), ADediting_1083699(53239515, -), ADediting_1083700(53239899, -), ADediting_1083701(53243200, -), ADediting_1083702(53246232, -), ADediting_1083703(53249333, -), ADediting_1083704(53249499, -), ADediting_1083705(53249500, -), ADediting_1083706(53250536, -), ADediting_1083707(53250568, -), ADediting_1083708(53250605, -), ADediting_1083709(53250663, -), ADediting_1083710(53250672, -), ADediting_1083711(53250688, -), ADediting_1083712(53250738, -), ADediting_1083713(53250741, -), ADediting_1083714(53250897, -), ADediting_1083715(53250920, -), ADediting_1083716(53250970, -), ADediting_1083717(53250974, -), ADediting_1083718(53250975, -), ADediting_1083719(53250983, -), ADediting_1083720(53250990, -), ADediting_1083721(53251022, -), ADediting_1083722(53251044, -), ADediting_1083723(53252018, -), ADediting_1083724(53252040, -), ADediting_1083725(53252057, -), ADediting_1083726(53252064, -), ADediting_1083727(53252922, -), ADediting_1083728(53252945, -), ADediting_1083729(53252951, -), ADediting_1083730(53252968, -), ADediting_1083731(53252977, -), ADediting_1083732(53252978, -), ADediting_1083733(53253004, -), ADediting_1083734(53253014, -), ADediting_1083735(53253034, -), ADediting_1083736(53253035, -), ADediting_1083737(53253044, -), ADediting_1083738(53253087, -), ADediting_1083739(53253137, -), ADediting_1083740(53253153, -), ADediting_1083741(53253400, -), ADediting_1083742(53253405, -), ADediting_1083743(53253418, -), ADediting_1083744(53253445, -), ADediting_1083745(53253541, -), ADediting_1083746(53253597, -), ADediting_1083747(53253599, -), ADediting_1083748(53253602, -), ADediting_1083749(53253617, -), ADediting_1083750(53253642, -), ADediting_1083751(53253664, -), ADediting_1083752(53253688, -), ADediting_1083753(53253701, -), ADediting_1083754(53253717, -), ADediting_1083755(53253720, -), ADediting_1083756(53253723, -), ADediting_1083757(53253829, -), ADediting_1083758(53253852, -), ADediting_1083759(53253853, -), ADediting_1083760(53253874, -), ADediting_1083761(53253875, -), ADediting_1575361(53237800, -), ADediting_1575362(53239424, -), ADediting_1575363(53253106, -), ADediting_1648185(53249095, -), ADediting_1648186(53249461, -), ADediting_1648187(53249471, -), |
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RNA editing positional annotations for TKT using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| ADediting_1575361 | chr3_53237800_- | nonsynonymous SNV | ENST00000423516.5 | c.A458G | p.Y153C | 0.178 | 0.926 | -0.18 |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_1083686 | chr3_53237288_- | intronic |
| ADediting_1083687 | chr3_53237302_- | intronic |
| ADediting_1083688 | chr3_53237822_- | splicing |
| ADediting_1083689 | chr3_53237842_- | UTR3 |
| ADediting_1083690 | chr3_53239433_- | intronic |
| ADediting_1083691 | chr3_53239437_- | intronic |
| ADediting_1083692 | chr3_53239465_- | intronic |
| ADediting_1083693 | chr3_53239469_- | intronic |
| ADediting_1083694 | chr3_53239485_- | intronic |
| ADediting_1083695 | chr3_53239488_- | intronic |
| ADediting_1083696 | chr3_53239489_- | intronic |
| ADediting_1083697 | chr3_53239491_- | intronic |
| ADediting_1083698 | chr3_53239502_- | intronic |
| ADediting_1083699 | chr3_53239515_- | intronic |
| ADediting_1083700 | chr3_53239899_- | intronic |
| ADediting_1083701 | chr3_53243200_- | intronic |
| ADediting_1083702 | chr3_53246232_- | intronic |
| ADediting_1083703 | chr3_53249333_- | intronic |
| ADediting_1083704 | chr3_53249499_- | intronic |
| ADediting_1083705 | chr3_53249500_- | intronic |
| ADediting_1083706 | chr3_53250536_- | intronic |
| ADediting_1083707 | chr3_53250568_- | intronic |
| ADediting_1083708 | chr3_53250605_- | intronic |
| ADediting_1083709 | chr3_53250663_- | intronic |
| ADediting_1083710 | chr3_53250672_- | intronic |
| ADediting_1083711 | chr3_53250688_- | intronic |
| ADediting_1083712 | chr3_53250738_- | intronic |
| ADediting_1083713 | chr3_53250741_- | intronic |
| ADediting_1083714 | chr3_53250897_- | intronic |
| ADediting_1083715 | chr3_53250920_- | intronic |
| ADediting_1083716 | chr3_53250970_- | intronic |
| ADediting_1083717 | chr3_53250974_- | intronic |
| ADediting_1083718 | chr3_53250975_- | intronic |
| ADediting_1083719 | chr3_53250983_- | intronic |
| ADediting_1083720 | chr3_53250990_- | intronic |
| ADediting_1083721 | chr3_53251022_- | intronic |
| ADediting_1083722 | chr3_53251044_- | intronic |
| ADediting_1083723 | chr3_53252018_- | intronic |
| ADediting_1083724 | chr3_53252040_- | intronic |
| ADediting_1083725 | chr3_53252057_- | intronic |
| ADediting_1083726 | chr3_53252064_- | intronic |
| ADediting_1083727 | chr3_53252922_- | intronic |
| ADediting_1083728 | chr3_53252945_- | intronic |
| ADediting_1083729 | chr3_53252951_- | intronic |
| ADediting_1083730 | chr3_53252968_- | intronic |
| ADediting_1083731 | chr3_53252977_- | intronic |
| ADediting_1083732 | chr3_53252978_- | intronic |
| ADediting_1083733 | chr3_53253004_- | intronic |
| ADediting_1083734 | chr3_53253014_- | intronic |
| ADediting_1083735 | chr3_53253034_- | intronic |
| ADediting_1083736 | chr3_53253035_- | intronic |
| ADediting_1083737 | chr3_53253044_- | intronic |
| ADediting_1083738 | chr3_53253087_- | intronic |
| ADediting_1083739 | chr3_53253137_- | intronic |
| ADediting_1083740 | chr3_53253153_- | intronic |
| ADediting_1083741 | chr3_53253400_- | intronic |
| ADediting_1083742 | chr3_53253405_- | intronic |
| ADediting_1083743 | chr3_53253418_- | intronic |
| ADediting_1083744 | chr3_53253445_- | intronic |
| ADediting_1083745 | chr3_53253541_- | intronic |
| ADediting_1083746 | chr3_53253597_- | intronic |
| ADediting_1083747 | chr3_53253599_- | intronic |
| ADediting_1083748 | chr3_53253602_- | intronic |
| ADediting_1083749 | chr3_53253617_- | intronic |
| ADediting_1083750 | chr3_53253642_- | intronic |
| ADediting_1083751 | chr3_53253664_- | intronic |
| ADediting_1083752 | chr3_53253688_- | intronic |
| ADediting_1083753 | chr3_53253701_- | intronic |
| ADediting_1083754 | chr3_53253717_- | intronic |
| ADediting_1083755 | chr3_53253720_- | intronic |
| ADediting_1083756 | chr3_53253723_- | intronic |
| ADediting_1083757 | chr3_53253829_- | intronic |
| ADediting_1083758 | chr3_53253852_- | intronic |
| ADediting_1083759 | chr3_53253853_- | intronic |
| ADediting_1083760 | chr3_53253874_- | intronic |
| ADediting_1083761 | chr3_53253875_- | intronic |
| ADediting_1575361 | chr3_53237800_- | exonic |
| ADediting_1575362 | chr3_53239424_- | intronic |
| ADediting_1575363 | chr3_53253106_- | intronic |
| ADediting_1648185 | chr3_53249095_- | intronic |
| ADediting_1648186 | chr3_53249461_- | intronic |
| ADediting_1648187 | chr3_53249471_- | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_1083686 | chr3_53237288_- | SINE | Alu | Name=AluSx |
| ADediting_1083687 | chr3_53237302_- | SINE | Alu | Name=AluSx |
| ADediting_1083688 | chr3_53237822_- | SINE | Alu | Name=AluSc8 |
| ADediting_1083689 | chr3_53237842_- | SINE | Alu | Name=AluSc8 |
| ADediting_1083690 | chr3_53239433_- | SINE | Alu | Name=AluJr |
| ADediting_1083691 | chr3_53239437_- | SINE | Alu | Name=AluJr |
| ADediting_1083692 | chr3_53239465_- | SINE | Alu | Name=AluJr |
| ADediting_1083693 | chr3_53239469_- | SINE | Alu | Name=AluJr |
| ADediting_1083694 | chr3_53239485_- | SINE | Alu | Name=AluJr |
| ADediting_1083695 | chr3_53239488_- | SINE | Alu | Name=AluJr |
| ADediting_1083696 | chr3_53239489_- | SINE | Alu | Name=AluJr |
| ADediting_1083697 | chr3_53239491_- | SINE | Alu | Name=AluJr |
| ADediting_1083698 | chr3_53239502_- | SINE | Alu | Name=AluJr |
| ADediting_1083699 | chr3_53239515_- | SINE | Alu | Name=AluJr |
| ADediting_1083702 | chr3_53246232_- | SINE | Alu | Name=AluSx1 |
| ADediting_1083703 | chr3_53249333_- | SINE | Alu | Name=AluSx |
| ADediting_1083704 | chr3_53249499_- | SINE | Alu | Name=AluSx |
| ADediting_1083705 | chr3_53249500_- | SINE | Alu | Name=AluSx |
| ADediting_1083706 | chr3_53250536_- | SINE | Alu | Name=AluJb |
| ADediting_1083707 | chr3_53250568_- | SINE | Alu | Name=AluJb |
| ADediting_1083708 | chr3_53250605_- | SINE | Alu | Name=AluJb |
| ADediting_1083709 | chr3_53250663_- | SINE | Alu | Name=AluJb |
| ADediting_1083710 | chr3_53250672_- | SINE | Alu | Name=AluJb |
| ADediting_1083711 | chr3_53250688_- | SINE | Alu | Name=AluJb |
| ADediting_1083712 | chr3_53250738_- | SINE | Alu | Name=AluJb |
| ADediting_1083713 | chr3_53250741_- | SINE | Alu | Name=AluJb |
| ADediting_1083714 | chr3_53250897_- | SINE | Alu | Name=AluJo |
| ADediting_1083715 | chr3_53250920_- | SINE | Alu | Name=AluJo |
| ADediting_1083716 | chr3_53250970_- | SINE | Alu | Name=AluJo |
| ADediting_1083717 | chr3_53250974_- | SINE | Alu | Name=AluJo |
| ADediting_1083718 | chr3_53250975_- | SINE | Alu | Name=AluJo |
| ADediting_1083719 | chr3_53250983_- | SINE | Alu | Name=AluJo |
| ADediting_1083720 | chr3_53250990_- | SINE | Alu | Name=AluJo |
| ADediting_1083721 | chr3_53251022_- | SINE | Alu | Name=AluJo |
| ADediting_1083722 | chr3_53251044_- | SINE | Alu | Name=AluJo |
| ADediting_1083723 | chr3_53252018_- | SINE | Alu | Name=AluSp |
| ADediting_1083724 | chr3_53252040_- | SINE | Alu | Name=AluSp |
| ADediting_1083725 | chr3_53252057_- | SINE | Alu | Name=AluSp |
| ADediting_1083726 | chr3_53252064_- | SINE | Alu | Name=AluSp |
| ADediting_1083727 | chr3_53252922_- | SINE | Alu | Name=AluSq2 |
| ADediting_1083728 | chr3_53252945_- | SINE | Alu | Name=AluSq2 |
| ADediting_1083729 | chr3_53252951_- | SINE | Alu | Name=AluSq2 |
| ADediting_1083730 | chr3_53252968_- | SINE | Alu | Name=AluSq2 |
| ADediting_1083731 | chr3_53252977_- | SINE | Alu | Name=AluSq2 |
| ADediting_1083732 | chr3_53252978_- | SINE | Alu | Name=AluSq2 |
| ADediting_1083733 | chr3_53253004_- | SINE | Alu | Name=AluSq2 |
| ADediting_1083734 | chr3_53253014_- | SINE | Alu | Name=AluSq2 |
| ADediting_1083735 | chr3_53253034_- | SINE | Alu | Name=AluSq2 |
| ADediting_1083736 | chr3_53253035_- | SINE | Alu | Name=AluSq2 |
| ADediting_1083737 | chr3_53253044_- | SINE | Alu | Name=AluSq2 |
| ADediting_1083738 | chr3_53253087_- | SINE | Alu | Name=AluSq2 |
| ADediting_1083739 | chr3_53253137_- | SINE | Alu | Name=AluSq2 |
| ADediting_1083740 | chr3_53253153_- | SINE | Alu | Name=AluJr |
| ADediting_1083741 | chr3_53253400_- | SINE | Alu | Name=AluJo |
| ADediting_1083742 | chr3_53253405_- | SINE | Alu | Name=AluJo |
| ADediting_1083743 | chr3_53253418_- | SINE | Alu | Name=AluJo |
| ADediting_1083744 | chr3_53253445_- | SINE | Alu | Name=AluJo |
| ADediting_1083745 | chr3_53253541_- | SINE | Alu | Name=AluSx1 |
| ADediting_1083746 | chr3_53253597_- | SINE | Alu | Name=AluSx1 |
| ADediting_1083747 | chr3_53253599_- | SINE | Alu | Name=AluSx1 |
| ADediting_1083748 | chr3_53253602_- | SINE | Alu | Name=AluSx1 |
| ADediting_1083749 | chr3_53253617_- | SINE | Alu | Name=AluSx1 |
| ADediting_1083750 | chr3_53253642_- | SINE | Alu | Name=AluSx1 |
| ADediting_1083751 | chr3_53253664_- | SINE | Alu | Name=AluSx1 |
| ADediting_1083752 | chr3_53253688_- | SINE | Alu | Name=AluSx1 |
| ADediting_1083753 | chr3_53253701_- | SINE | Alu | Name=AluSx1 |
| ADediting_1083754 | chr3_53253717_- | SINE | Alu | Name=AluSx1 |
| ADediting_1083755 | chr3_53253720_- | SINE | Alu | Name=AluSx1 |
| ADediting_1083756 | chr3_53253723_- | SINE | Alu | Name=AluSx1 |
| ADediting_1083757 | chr3_53253829_- | SINE | Alu | Name=AluJo |
| ADediting_1083758 | chr3_53253852_- | SINE | Alu | Name=AluJo |
| ADediting_1083759 | chr3_53253853_- | SINE | Alu | Name=AluJo |
| ADediting_1083760 | chr3_53253874_- | SINE | Alu | Name=AluJo |
| ADediting_1083761 | chr3_53253875_- | SINE | Alu | Name=AluJo |
| ADediting_1575361 | chr3_53237800_- | SINE | Alu | Name=AluSc8 |
| ADediting_1575362 | chr3_53239424_- | SINE | Alu | Name=AluJr |
| ADediting_1575363 | chr3_53253106_- | SINE | Alu | Name=AluSq2 |
| ADediting_1648185 | chr3_53249095_- | SINE | Alu | Name=AluSx1 |
| ADediting_1648186 | chr3_53249461_- | SINE | Alu | Name=AluSx |
| ADediting_1648187 | chr3_53249471_- | SINE | Alu | Name=AluSx |
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RNA A-to-I editing events in the alternative splicing sites for TKT |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| A3SS | ADediting_1083688 | chr3_53237822_- | 53237818:53237840 | 3ss | 2i | TGATTCTCCTCCTGCCTCAGCCT | 5.32 | TGATTCTCCTCCTGCCTCGGCCT | -2.64 |
| ES | ADediting_1083688 | chr3_53237822_- | 53237818:53237840 | 3ss | 2i | TGATTCTCCTCCTGCCTCAGCCT | 5.32 | TGATTCTCCTCCTGCCTCGGCCT | -2.64 |
| ES | ADediting_1083688 | chr3_53237822_- | 53237818:53237840 | 3ss | 2i | TGATTCTCCTCCTGCCTCAGCCT | 5.32 | TGATTCTCCTCCTGCCTCGGCCT | -2.64 |
| ES | ADediting_1083688 | chr3_53237822_- | 53237818:53237840 | 3ss | 2i | TGATTCTCCTCCTGCCTCAGCCT | 5.32 | TGATTCTCCTCCTGCCTCGGCCT | -2.64 |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for TKT |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |