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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for TGFB1 |
 Gene summary |
| Gene information | Gene symbol | TGFB1 | Gene ID | 7040 |
| Gene name | transforming growth factor beta 1 | |
| Synonyms | CED|DPD1|IBDIMDE|LAP|TGF-beta1|TGFB|TGFbeta | |
| Cytomap | 19q13.2 | |
| Type of gene | protein-coding | |
| Description | transforming growth factor beta-1 proproteinTGF-beta-1latency-associated peptideprepro-transforming growth factor beta-1transforming growth factor beta1 | |
| Modification date | 20200329 | |
| UniProtAcc | P01137, | |
| Context | - 16082716(Association Studies of Transforming Growth Factor-Beta 1 and Alzheimer's Disease) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| TGFB1 | GO:0001837 | epithelial to mesenchymal transition | 25893292|29529050 |
| TGFB1 | GO:0001933 | negative regulation of protein phosphorylation | 8053900 |
| TGFB1 | GO:0001934 | positive regulation of protein phosphorylation | 18625725 |
| TGFB1 | GO:0002062 | chondrocyte differentiation | 15040835 |
| TGFB1 | GO:0002244 | hematopoietic progenitor cell differentiation | 15451575 |
| TGFB1 | GO:0006611 | protein export from nucleus | 9770491|17438144|18588859 |
| TGFB1 | GO:0006754 | ATP biosynthetic process | 10513816 |
| TGFB1 | GO:0006796 | phosphate-containing compound metabolic process | 10513816 |
| TGFB1 | GO:0006954 | inflammatory response | 21147091 |
| TGFB1 | GO:0007050 | cell cycle arrest | 14555988 |
| TGFB1 | GO:0007093 | mitotic cell cycle checkpoint | 15334054 |
| TGFB1 | GO:0007173 | epidermal growth factor receptor signaling pathway | 18625725 |
| TGFB1 | GO:0007179 | transforming growth factor beta receptor signaling pathway | 9389648|11157754 |
| TGFB1 | GO:0007182 | common-partner SMAD protein phosphorylation | 20573232 |
| TGFB1 | GO:0007183 | SMAD protein complex assembly | 17438144 |
| TGFB1 | GO:0008284 | positive regulation of cell proliferation | 10513816|14633705 |
| TGFB1 | GO:0008285 | negative regulation of cell proliferation | 15334054 |
| TGFB1 | GO:0010628 | positive regulation of gene expression | 18625725|18832382|18941241|19913496|25322725|26634652|26687115|27162619|29167509 |
| TGFB1 | GO:0010629 | negative regulation of gene expression | 19913496|20067797|22269326|25163461|26634652|29167509|29529050 |
| TGFB1 | GO:0010718 | positive regulation of epithelial to mesenchymal transition | 17999987|18505915 |
| TGFB1 | GO:0010763 | positive regulation of fibroblast migration | 18555217 |
| TGFB1 | GO:0010800 | positive regulation of peptidyl-threonine phosphorylation | 18625725|19736306 |
| TGFB1 | GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation | 9389648|19736306|26634652 |
| TGFB1 | GO:0010936 | negative regulation of macrophage cytokine production | 20875417 |
| TGFB1 | GO:0016477 | cell migration | 25893292 |
| TGFB1 | GO:0017015 | regulation of transforming growth factor beta receptor signaling pathway | 15334054 |
| TGFB1 | GO:0022408 | negative regulation of cell-cell adhesion | 18593713 |
| TGFB1 | GO:0030214 | hyaluronan catabolic process | 17324121 |
| TGFB1 | GO:0030308 | negative regulation of cell growth | 15334054 |
| TGFB1 | GO:0030335 | positive regulation of cell migration | 19736306 |
| TGFB1 | GO:0031293 | membrane protein intracellular domain proteolysis | 25310401 |
| TGFB1 | GO:0031334 | positive regulation of protein complex assembly | 19366691 |
| TGFB1 | GO:0031663 | lipopolysaccharide-mediated signaling pathway | 21147091 |
| TGFB1 | GO:0032270 | positive regulation of cellular protein metabolic process | 15219857 |
| TGFB1 | GO:0032355 | response to estradiol | 18039789 |
| TGFB1 | GO:0032570 | response to progesterone | 18039789 |
| TGFB1 | GO:0032740 | positive regulation of interleukin-17 production | 18453574 |
| TGFB1 | GO:0032801 | receptor catabolic process | 17878231 |
| TGFB1 | GO:0032930 | positive regulation of superoxide anion generation | 22073128 |
| TGFB1 | GO:0032967 | positive regulation of collagen biosynthetic process | 19734317|22269326|25310401 |
| TGFB1 | GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 18625725|19736306 |
| TGFB1 | GO:0035307 | positive regulation of protein dephosphorylation | 14555988 |
| TGFB1 | GO:0042307 | positive regulation of protein import into nucleus | 19366691 |
| TGFB1 | GO:0043117 | positive regulation of vascular permeability | 21168935 |
| TGFB1 | GO:0043406 | positive regulation of MAP kinase activity | 18625725 |
| TGFB1 | GO:0043536 | positive regulation of blood vessel endothelial cell migration | 18555217 |
| TGFB1 | GO:0043537 | negative regulation of blood vessel endothelial cell migration | 18555217 |
| TGFB1 | GO:0043552 | positive regulation of phosphatidylinositol 3-kinase activity | 18625725 |
| TGFB1 | GO:0045216 | cell-cell junction organization | 18505915 |
| TGFB1 | GO:0045599 | negative regulation of fat cell differentiation | 15040835 |
| TGFB1 | GO:0045662 | negative regulation of myoblast differentiation | 9770491 |
| TGFB1 | GO:0045786 | negative regulation of cell cycle | 11502704 |
| TGFB1 | GO:0045892 | negative regulation of transcription, DNA-templated | 15702480|18832382 |
| TGFB1 | GO:0045893 | positive regulation of transcription, DNA-templated | 9389648|14517293|15334054|16816361 |
| TGFB1 | GO:0045918 | negative regulation of cytolysis | 24586048 |
| TGFB1 | GO:0045930 | negative regulation of mitotic cell cycle | 14555988 |
| TGFB1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 18832382 |
| TGFB1 | GO:0048298 | positive regulation of isotype switching to IgA isotypes | 14988498 |
| TGFB1 | GO:0048642 | negative regulation of skeletal muscle tissue development | 9770491 |
| TGFB1 | GO:0050680 | negative regulation of epithelial cell proliferation | 9950587 |
| TGFB1 | GO:0050714 | positive regulation of protein secretion | 18505915 |
| TGFB1 | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 21168935 |
| TGFB1 | GO:0050921 | positive regulation of chemotaxis | 18555217 |
| TGFB1 | GO:0051897 | positive regulation of protein kinase B signaling | 18625725 |
| TGFB1 | GO:0060389 | pathway-restricted SMAD protein phosphorylation | 11157754|17999987|18453574|25893292 |
| TGFB1 | GO:0060390 | regulation of SMAD protein signal transduction | 25893292 |
| TGFB1 | GO:0060391 | positive regulation of SMAD protein signal transduction | 9389648|19366691|29167509 |
| TGFB1 | GO:0070168 | negative regulation of biomineral tissue development | 26634652 |
| TGFB1 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 25310401 |
| TGFB1 | GO:0070723 | response to cholesterol | 17878231 |
| TGFB1 | GO:0071407 | cellular response to organic cyclic compound | 21147091 |
| TGFB1 | GO:0071560 | cellular response to transforming growth factor beta stimulus | 19736306|22269326 |
| TGFB1 | GO:0085029 | extracellular matrix assembly | 19734317 |
| TGFB1 | GO:0090263 | positive regulation of canonical Wnt signaling pathway | 12893825|15040835 |
| TGFB1 | GO:0097191 | extrinsic apoptotic signaling pathway | 15334054 |
| TGFB1 | GO:1900126 | negative regulation of hyaluronan biosynthetic process | 17324121 |
| TGFB1 | GO:1900182 | positive regulation of protein localization to nucleus | 26634652 |
| TGFB1 | GO:1901666 | positive regulation of NAD+ ADP-ribosyltransferase activity | 22073128 |
| TGFB1 | GO:1902895 | positive regulation of pri-miRNA transcription by RNA polymerase II | 26311719|26493107 |
| TGFB1 | GO:1903077 | negative regulation of protein localization to plasma membrane | 21168935|24586048 |
| TGFB1 | GO:1903800 | positive regulation of production of miRNAs involved in gene silencing by miRNA | 18548003 |
| TGFB1 | GO:2000679 | positive regulation of transcription regulatory region DNA binding | 22073128 |
| TGFB1 | GO:2000727 | positive regulation of cardiac muscle cell differentiation | 25163461 |
Top |
RNA A-to-I events for TGFB1 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
 |
| RNA editing frequencies across three data sets. |
 |
| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
 |
| RNA A-to-I editing events in AD. |
| ADediting_754294(41329616, -), ADediting_754295(41329652, -), ADediting_754296(41329661, -), ADediting_754297(41329663, -), ADediting_754298(41329728, -), ADediting_754299(41329753, -), ADediting_754300(41329758, -), ADediting_754301(41329759, -), ADediting_754302(41329775, -), ADediting_754303(41329847, -), ADediting_754304(41329866, -), ADediting_754305(41329892, -), ADediting_754306(41329972, -), ADediting_754307(41329975, -), ADediting_754308(41329978, -), ADediting_754309(41329989, -), ADediting_754310(41329990, -), ADediting_754311(41329991, -), ADediting_754312(41330018, -), ADediting_754313(41330055, -), ADediting_754314(41330069, -), ADediting_754315(41330072, -), ADediting_754316(41330110, -), ADediting_754317(41330116, -), ADediting_754318(41330126, -), ADediting_754319(41330146, -), ADediting_754320(41330163, -), ADediting_754321(41330164, -), ADediting_754322(41330183, -), ADediting_754323(41330186, -), ADediting_754324(41330277, -), ADediting_754325(41330278, -), ADediting_754326(41330324, -), ADediting_754327(41330331, -), ADediting_754328(41330350, -), ADediting_754329(41330364, -), ADediting_754330(41330433, -), ADediting_754331(41330530, -), ADediting_754332(41333350, -), ADediting_754333(41333377, -), ADediting_754334(41333483, -), ADediting_754335(41333494, -), ADediting_754336(41334130, -), ADediting_754337(41334149, -), ADediting_754338(41334172, -), ADediting_754339(41334212, -), ADediting_754340(41334253, -), ADediting_754341(41334275, -), ADediting_754342(41334293, -), ADediting_754343(41334332, -), ADediting_754344(41334338, -), ADediting_754345(41334572, -), ADediting_754346(41334634, -), ADediting_754347(41334656, -), ADediting_754348(41334666, -), ADediting_754349(41334678, -), ADediting_754350(41335176, -), ADediting_754351(41335213, -), ADediting_754352(41335217, -), ADediting_754353(41335236, -), ADediting_754354(41335326, -), ADediting_754355(41335771, -), ADediting_754356(41336160, -), ADediting_754357(41336277, -), ADediting_754358(41337096, -), ADediting_754359(41337305, -), ADediting_754360(41337344, -), ADediting_754361(41337420, -), ADediting_754362(41337436, -), ADediting_754363(41337563, -), ADediting_754364(41337572, -), ADediting_754365(41338026, -), ADediting_754366(41338082, -), ADediting_754367(41338382, -), ADediting_754368(41338444, -), ADediting_754369(41338588, -), ADediting_754370(41338618, -), ADediting_754371(41338717, -), ADediting_754372(41338727, -), ADediting_754373(41338739, -), ADediting_754374(41338756, -), ADediting_754375(41339187, -), ADediting_754376(41339195, -), ADediting_754377(41339211, -), ADediting_754378(41339254, -), ADediting_754379(41339338, -), ADediting_754380(41339361, -), ADediting_754381(41339391, -), ADediting_754382(41339392, -), ADediting_754383(41339414, -), ADediting_754384(41340328, -), ADediting_754385(41340475, -), ADediting_754386(41340485, -), ADediting_754387(41340486, -), ADediting_754388(41340500, -), ADediting_754389(41340545, -), ADediting_754390(41340553, -), ADediting_754391(41340554, -), ADediting_754392(41340556, -), ADediting_754393(41341073, -), ADediting_754394(41341075, -), ADediting_754395(41341142, -), ADediting_754396(41341164, -), ADediting_754397(41341167, -), ADediting_754398(41341277, -), ADediting_754399(41341299, -), ADediting_754400(41341302, -), ADediting_754401(41341351, -), ADediting_754402(41341355, -), ADediting_754403(41341571, -), ADediting_754404(41341613, -), ADediting_754405(41341614, -), ADediting_754406(41341656, -), ADediting_754407(41341676, -), ADediting_754408(41341705, -), ADediting_754409(41345411, -), ADediting_754410(41347625, -), ADediting_754411(41347662, -), ADediting_754412(41347765, -), ADediting_754413(41347889, -), ADediting_754414(41347890, -), ADediting_754415(41348069, -), ADediting_754416(41348894, -), ADediting_754417(41348895, -), ADediting_754418(41348901, -), ADediting_754419(41349536, -), ADediting_754420(41349588, -), ADediting_754421(41349591, -), ADediting_754422(41349594, -), ADediting_754423(41349609, -), ADediting_754424(41349635, -), ADediting_754425(41349656, -), ADediting_754426(41349670, -), ADediting_754427(41349674, -), ADediting_754428(41349681, -), ADediting_754429(41349697, -), ADediting_754430(41349735, -), ADediting_754431(41349751, -), ADediting_754432(41350416, -), ADediting_754433(41350472, -), ADediting_754434(41350478, -), ADediting_754435(41350481, -), ADediting_1556202(41330363, -), |
Top |
RNA editing positional annotations for TGFB1 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_754294 | chr19_41329616_- | intronic |
| ADediting_754295 | chr19_41329652_- | intronic |
| ADediting_754296 | chr19_41329661_- | intronic |
| ADediting_754297 | chr19_41329663_- | intronic |
| ADediting_754298 | chr19_41329728_- | intronic |
| ADediting_754299 | chr19_41329753_- | intronic |
| ADediting_754300 | chr19_41329758_- | intronic |
| ADediting_754301 | chr19_41329759_- | intronic |
| ADediting_754302 | chr19_41329775_- | intronic |
| ADediting_754303 | chr19_41329847_- | intronic |
| ADediting_754304 | chr19_41329866_- | intronic |
| ADediting_754305 | chr19_41329892_- | intronic |
| ADediting_754306 | chr19_41329972_- | intronic |
| ADediting_754307 | chr19_41329975_- | intronic |
| ADediting_754308 | chr19_41329978_- | intronic |
| ADediting_754309 | chr19_41329989_- | intronic |
| ADediting_754310 | chr19_41329990_- | intronic |
| ADediting_754311 | chr19_41329991_- | intronic |
| ADediting_754312 | chr19_41330018_- | intronic |
| ADediting_754313 | chr19_41330055_- | intronic |
| ADediting_754314 | chr19_41330069_- | intronic |
| ADediting_754315 | chr19_41330072_- | intronic |
| ADediting_754316 | chr19_41330110_- | intronic |
| ADediting_754317 | chr19_41330116_- | intronic |
| ADediting_754318 | chr19_41330126_- | intronic |
| ADediting_754319 | chr19_41330146_- | intronic |
| ADediting_754320 | chr19_41330163_- | intronic |
| ADediting_754321 | chr19_41330164_- | intronic |
| ADediting_754322 | chr19_41330183_- | intronic |
| ADediting_754323 | chr19_41330186_- | intronic |
| ADediting_754324 | chr19_41330277_- | intronic |
| ADediting_754325 | chr19_41330278_- | intronic |
| ADediting_754326 | chr19_41330324_- | UTR3 |
| ADediting_754327 | chr19_41330331_- | UTR3 |
| ADediting_754328 | chr19_41330350_- | UTR3 |
| ADediting_754329 | chr19_41330364_- | UTR3 |
| ADediting_754330 | chr19_41330433_- | UTR3 |
| ADediting_754331 | chr19_41330530_- | UTR3 |
| ADediting_754332 | chr19_41333350_- | intronic |
| ADediting_754333 | chr19_41333377_- | intronic |
| ADediting_754334 | chr19_41333483_- | intronic |
| ADediting_754335 | chr19_41333494_- | intronic |
| ADediting_754336 | chr19_41334130_- | intronic |
| ADediting_754337 | chr19_41334149_- | intronic |
| ADediting_754338 | chr19_41334172_- | intronic |
| ADediting_754339 | chr19_41334212_- | intronic |
| ADediting_754340 | chr19_41334253_- | intronic |
| ADediting_754341 | chr19_41334275_- | intronic |
| ADediting_754342 | chr19_41334293_- | intronic |
| ADediting_754343 | chr19_41334332_- | intronic |
| ADediting_754344 | chr19_41334338_- | intronic |
| ADediting_754345 | chr19_41334572_- | intronic |
| ADediting_754346 | chr19_41334634_- | intronic |
| ADediting_754347 | chr19_41334656_- | intronic |
| ADediting_754348 | chr19_41334666_- | intronic |
| ADediting_754349 | chr19_41334678_- | intronic |
| ADediting_754350 | chr19_41335176_- | intronic |
| ADediting_754351 | chr19_41335213_- | intronic |
| ADediting_754352 | chr19_41335217_- | intronic |
| ADediting_754353 | chr19_41335236_- | intronic |
| ADediting_754354 | chr19_41335326_- | intronic |
| ADediting_754355 | chr19_41335771_- | intronic |
| ADediting_754356 | chr19_41336160_- | intronic |
| ADediting_754357 | chr19_41336277_- | intronic |
| ADediting_754358 | chr19_41337096_- | intronic |
| ADediting_754359 | chr19_41337305_- | intronic |
| ADediting_754360 | chr19_41337344_- | intronic |
| ADediting_754361 | chr19_41337420_- | intronic |
| ADediting_754362 | chr19_41337436_- | intronic |
| ADediting_754363 | chr19_41337563_- | intronic |
| ADediting_754364 | chr19_41337572_- | intronic |
| ADediting_754365 | chr19_41338026_- | intronic |
| ADediting_754366 | chr19_41338082_- | intronic |
| ADediting_754367 | chr19_41338382_- | intronic |
| ADediting_754368 | chr19_41338444_- | intronic |
| ADediting_754369 | chr19_41338588_- | intronic |
| ADediting_754370 | chr19_41338618_- | intronic |
| ADediting_754371 | chr19_41338717_- | intronic |
| ADediting_754372 | chr19_41338727_- | intronic |
| ADediting_754373 | chr19_41338739_- | intronic |
| ADediting_754374 | chr19_41338756_- | intronic |
| ADediting_754375 | chr19_41339187_- | intronic |
| ADediting_754376 | chr19_41339195_- | intronic |
| ADediting_754377 | chr19_41339211_- | intronic |
| ADediting_754378 | chr19_41339254_- | intronic |
| ADediting_754379 | chr19_41339338_- | intronic |
| ADediting_754380 | chr19_41339361_- | intronic |
| ADediting_754381 | chr19_41339391_- | intronic |
| ADediting_754382 | chr19_41339392_- | intronic |
| ADediting_754383 | chr19_41339414_- | intronic |
| ADediting_754384 | chr19_41340328_- | intronic |
| ADediting_754385 | chr19_41340475_- | intronic |
| ADediting_754386 | chr19_41340485_- | intronic |
| ADediting_754387 | chr19_41340486_- | intronic |
| ADediting_754388 | chr19_41340500_- | intronic |
| ADediting_754389 | chr19_41340545_- | intronic |
| ADediting_754390 | chr19_41340553_- | intronic |
| ADediting_754391 | chr19_41340554_- | intronic |
| ADediting_754392 | chr19_41340556_- | intronic |
| ADediting_754393 | chr19_41341073_- | intronic |
| ADediting_754394 | chr19_41341075_- | intronic |
| ADediting_754395 | chr19_41341142_- | intronic |
| ADediting_754396 | chr19_41341164_- | intronic |
| ADediting_754397 | chr19_41341167_- | intronic |
| ADediting_754398 | chr19_41341277_- | intronic |
| ADediting_754399 | chr19_41341299_- | intronic |
| ADediting_754400 | chr19_41341302_- | intronic |
| ADediting_754401 | chr19_41341351_- | intronic |
| ADediting_754402 | chr19_41341355_- | intronic |
| ADediting_754403 | chr19_41341571_- | intronic |
| ADediting_754404 | chr19_41341613_- | intronic |
| ADediting_754405 | chr19_41341614_- | intronic |
| ADediting_754406 | chr19_41341656_- | intronic |
| ADediting_754407 | chr19_41341676_- | intronic |
| ADediting_754408 | chr19_41341705_- | intronic |
| ADediting_754409 | chr19_41345411_- | intronic |
| ADediting_754410 | chr19_41347625_- | intronic |
| ADediting_754411 | chr19_41347662_- | intronic |
| ADediting_754412 | chr19_41347765_- | intronic |
| ADediting_754413 | chr19_41347889_- | intronic |
| ADediting_754414 | chr19_41347890_- | intronic |
| ADediting_754415 | chr19_41348069_- | intronic |
| ADediting_754416 | chr19_41348894_- | intronic |
| ADediting_754417 | chr19_41348895_- | intronic |
| ADediting_754418 | chr19_41348901_- | intronic |
| ADediting_754419 | chr19_41349536_- | intronic |
| ADediting_754420 | chr19_41349588_- | intronic |
| ADediting_754421 | chr19_41349591_- | intronic |
| ADediting_754422 | chr19_41349594_- | intronic |
| ADediting_754423 | chr19_41349609_- | intronic |
| ADediting_754424 | chr19_41349635_- | intronic |
| ADediting_754425 | chr19_41349656_- | intronic |
| ADediting_754426 | chr19_41349670_- | intronic |
| ADediting_754427 | chr19_41349674_- | intronic |
| ADediting_754428 | chr19_41349681_- | intronic |
| ADediting_754429 | chr19_41349697_- | intronic |
| ADediting_754430 | chr19_41349735_- | intronic |
| ADediting_754431 | chr19_41349751_- | intronic |
| ADediting_754432 | chr19_41350416_- | intronic |
| ADediting_754433 | chr19_41350472_- | intronic |
| ADediting_754434 | chr19_41350478_- | intronic |
| ADediting_754435 | chr19_41350481_- | intronic |
| ADediting_1556202 | chr19_41330363_- | UTR3 |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_754294 | chr19_41329616_- | SINE | Alu | Name=AluSg |
| ADediting_754295 | chr19_41329652_- | SINE | Alu | Name=AluSg |
| ADediting_754296 | chr19_41329661_- | SINE | Alu | Name=AluSg |
| ADediting_754297 | chr19_41329663_- | SINE | Alu | Name=AluSg |
| ADediting_754298 | chr19_41329728_- | SINE | Alu | Name=AluSg |
| ADediting_754299 | chr19_41329753_- | SINE | Alu | Name=AluSg |
| ADediting_754300 | chr19_41329758_- | SINE | Alu | Name=AluSg |
| ADediting_754301 | chr19_41329759_- | SINE | Alu | Name=AluSg |
| ADediting_754302 | chr19_41329775_- | SINE | Alu | Name=AluSg |
| ADediting_754303 | chr19_41329847_- | SINE | Alu | Name=AluSz |
| ADediting_754304 | chr19_41329866_- | SINE | Alu | Name=AluSz |
| ADediting_754305 | chr19_41329892_- | SINE | Alu | Name=AluSz |
| ADediting_754306 | chr19_41329972_- | SINE | Alu | Name=AluSp |
| ADediting_754307 | chr19_41329975_- | SINE | Alu | Name=AluSp |
| ADediting_754308 | chr19_41329978_- | SINE | Alu | Name=AluSp |
| ADediting_754309 | chr19_41329989_- | SINE | Alu | Name=AluSp |
| ADediting_754310 | chr19_41329990_- | SINE | Alu | Name=AluSp |
| ADediting_754311 | chr19_41329991_- | SINE | Alu | Name=AluSp |
| ADediting_754312 | chr19_41330018_- | SINE | Alu | Name=AluSp |
| ADediting_754313 | chr19_41330055_- | SINE | Alu | Name=AluSp |
| ADediting_754314 | chr19_41330069_- | SINE | Alu | Name=AluSp |
| ADediting_754315 | chr19_41330072_- | SINE | Alu | Name=AluSp |
| ADediting_754316 | chr19_41330110_- | SINE | Alu | Name=AluSp |
| ADediting_754317 | chr19_41330116_- | SINE | Alu | Name=AluSp |
| ADediting_754318 | chr19_41330126_- | SINE | Alu | Name=AluSp |
| ADediting_754319 | chr19_41330146_- | SINE | Alu | Name=AluSp |
| ADediting_754320 | chr19_41330163_- | SINE | Alu | Name=AluSp |
| ADediting_754321 | chr19_41330164_- | SINE | Alu | Name=AluSp |
| ADediting_754322 | chr19_41330183_- | SINE | Alu | Name=AluSp |
| ADediting_754323 | chr19_41330186_- | SINE | Alu | Name=AluSp |
| ADediting_754324 | chr19_41330277_- | SINE | Alu | Name=AluJb |
| ADediting_754325 | chr19_41330278_- | SINE | Alu | Name=AluJb |
| ADediting_754326 | chr19_41330324_- | SINE | Alu | Name=AluJb |
| ADediting_754327 | chr19_41330331_- | SINE | Alu | Name=AluJb |
| ADediting_754328 | chr19_41330350_- | SINE | Alu | Name=AluJb |
| ADediting_754329 | chr19_41330364_- | SINE | Alu | Name=AluJb |
| ADediting_754330 | chr19_41330433_- | SINE | Alu | Name=AluJb |
| ADediting_754331 | chr19_41330530_- | SINE | Alu | Name=AluJb |
| ADediting_754332 | chr19_41333350_- | SINE | Alu | Name=AluSx3 |
| ADediting_754333 | chr19_41333377_- | SINE | Alu | Name=AluSx3 |
| ADediting_754334 | chr19_41333483_- | SINE | Alu | Name=AluSx3 |
| ADediting_754335 | chr19_41333494_- | SINE | Alu | Name=AluSx3 |
| ADediting_754336 | chr19_41334130_- | SINE | Alu | Name=AluSz6 |
| ADediting_754337 | chr19_41334149_- | SINE | Alu | Name=AluSz6 |
| ADediting_754338 | chr19_41334172_- | SINE | Alu | Name=AluSz6 |
| ADediting_754339 | chr19_41334212_- | SINE | Alu | Name=AluSz6 |
| ADediting_754340 | chr19_41334253_- | SINE | Alu | Name=AluSz6 |
| ADediting_754341 | chr19_41334275_- | SINE | Alu | Name=AluSz6 |
| ADediting_754342 | chr19_41334293_- | SINE | Alu | Name=AluSz6 |
| ADediting_754343 | chr19_41334332_- | SINE | Alu | Name=AluSz6 |
| ADediting_754344 | chr19_41334338_- | SINE | Alu | Name=AluSz6 |
| ADediting_754345 | chr19_41334572_- | SINE | Alu | Name=AluSx1 |
| ADediting_754346 | chr19_41334634_- | SINE | Alu | Name=AluSx1 |
| ADediting_754347 | chr19_41334656_- | SINE | Alu | Name=AluSx1 |
| ADediting_754348 | chr19_41334666_- | SINE | Alu | Name=AluSx1 |
| ADediting_754349 | chr19_41334678_- | SINE | Alu | Name=AluSx1 |
| ADediting_754350 | chr19_41335176_- | SINE | Alu | Name=AluSq2 |
| ADediting_754351 | chr19_41335213_- | SINE | Alu | Name=AluSq2 |
| ADediting_754352 | chr19_41335217_- | SINE | Alu | Name=AluSq2 |
| ADediting_754353 | chr19_41335236_- | SINE | Alu | Name=AluSq2 |
| ADediting_754354 | chr19_41335326_- | SINE | Alu | Name=AluSq2 |
| ADediting_754355 | chr19_41335771_- | SINE | Alu | Name=AluJo |
| ADediting_754356 | chr19_41336160_- | SINE | Alu | Name=AluSx |
| ADediting_754357 | chr19_41336277_- | SINE | Alu | Name=AluSx |
| ADediting_754358 | chr19_41337096_- | SINE | Alu | Name=AluSx1 |
| ADediting_754359 | chr19_41337305_- | SINE | Alu | Name=AluSq2 |
| ADediting_754360 | chr19_41337344_- | SINE | Alu | Name=AluSq2 |
| ADediting_754361 | chr19_41337420_- | SINE | Alu | Name=AluSq2 |
| ADediting_754362 | chr19_41337436_- | SINE | Alu | Name=AluSq2 |
| ADediting_754363 | chr19_41337563_- | SINE | Alu | Name=AluSx1 |
| ADediting_754364 | chr19_41337572_- | SINE | Alu | Name=AluSx1 |
| ADediting_754365 | chr19_41338026_- | SINE | Alu | Name=AluSx1 |
| ADediting_754366 | chr19_41338082_- | SINE | Alu | Name=AluSx1 |
| ADediting_754367 | chr19_41338382_- | SINE | Alu | Name=AluSq2 |
| ADediting_754368 | chr19_41338444_- | SINE | Alu | Name=AluSq2 |
| ADediting_754369 | chr19_41338588_- | SINE | Alu | Name=AluSx1 |
| ADediting_754370 | chr19_41338618_- | SINE | Alu | Name=AluSx1 |
| ADediting_754371 | chr19_41338717_- | SINE | Alu | Name=AluSx1 |
| ADediting_754372 | chr19_41338727_- | SINE | Alu | Name=AluSx1 |
| ADediting_754373 | chr19_41338739_- | SINE | Alu | Name=AluSx1 |
| ADediting_754374 | chr19_41338756_- | SINE | Alu | Name=AluSx1 |
| ADediting_754375 | chr19_41339187_- | SINE | Alu | Name=AluJb |
| ADediting_754376 | chr19_41339195_- | SINE | Alu | Name=AluJb |
| ADediting_754377 | chr19_41339211_- | SINE | Alu | Name=AluJb |
| ADediting_754378 | chr19_41339254_- | SINE | Alu | Name=AluJb |
| ADediting_754379 | chr19_41339338_- | SINE | Alu | Name=AluJb |
| ADediting_754380 | chr19_41339361_- | SINE | Alu | Name=AluJb |
| ADediting_754381 | chr19_41339391_- | SINE | Alu | Name=AluJb |
| ADediting_754382 | chr19_41339392_- | SINE | Alu | Name=AluJb |
| ADediting_754383 | chr19_41339414_- | SINE | Alu | Name=AluJb |
| ADediting_754384 | chr19_41340328_- | SINE | Alu | Name=AluSx1 |
| ADediting_754385 | chr19_41340475_- | SINE | Alu | Name=AluSx1 |
| ADediting_754386 | chr19_41340485_- | SINE | Alu | Name=AluSx1 |
| ADediting_754387 | chr19_41340486_- | SINE | Alu | Name=AluSx1 |
| ADediting_754388 | chr19_41340500_- | SINE | Alu | Name=AluSx1 |
| ADediting_754389 | chr19_41340545_- | SINE | Alu | Name=AluSx1 |
| ADediting_754390 | chr19_41340553_- | SINE | Alu | Name=AluSx1 |
| ADediting_754391 | chr19_41340554_- | SINE | Alu | Name=AluSx1 |
| ADediting_754392 | chr19_41340556_- | SINE | Alu | Name=AluSx1 |
| ADediting_754393 | chr19_41341073_- | SINE | Alu | Name=AluY |
| ADediting_754394 | chr19_41341075_- | SINE | Alu | Name=AluY |
| ADediting_754395 | chr19_41341142_- | SINE | Alu | Name=AluY |
| ADediting_754396 | chr19_41341164_- | SINE | Alu | Name=AluY |
| ADediting_754397 | chr19_41341167_- | SINE | Alu | Name=AluY |
| ADediting_754398 | chr19_41341277_- | SINE | Alu | Name=AluSc8 |
| ADediting_754399 | chr19_41341299_- | SINE | Alu | Name=AluSc8 |
| ADediting_754400 | chr19_41341302_- | SINE | Alu | Name=AluSc8 |
| ADediting_754401 | chr19_41341351_- | SINE | Alu | Name=AluSc8 |
| ADediting_754402 | chr19_41341355_- | SINE | Alu | Name=AluSc8 |
| ADediting_754403 | chr19_41341571_- | SINE | Alu | Name=AluSx1 |
| ADediting_754404 | chr19_41341613_- | SINE | Alu | Name=AluSx1 |
| ADediting_754405 | chr19_41341614_- | SINE | Alu | Name=AluSx1 |
| ADediting_754406 | chr19_41341656_- | SINE | Alu | Name=AluSx1 |
| ADediting_754407 | chr19_41341676_- | SINE | Alu | Name=AluSx1 |
| ADediting_754408 | chr19_41341705_- | SINE | Alu | Name=AluSx1 |
| ADediting_754409 | chr19_41345411_- | SINE | Alu | Name=AluSz |
| ADediting_754410 | chr19_41347625_- | SINE | Alu | Name=AluSz |
| ADediting_754411 | chr19_41347662_- | SINE | Alu | Name=AluSz |
| ADediting_754412 | chr19_41347765_- | SINE | Alu | Name=AluSz |
| ADediting_754413 | chr19_41347889_- | SINE | Alu | Name=AluSc |
| ADediting_754414 | chr19_41347890_- | SINE | Alu | Name=AluSc |
| ADediting_754415 | chr19_41348069_- | SINE | Alu | Name=AluSc |
| ADediting_754416 | chr19_41348894_- | SINE | Alu | Name=AluSc8 |
| ADediting_754417 | chr19_41348895_- | SINE | Alu | Name=AluSc8 |
| ADediting_754418 | chr19_41348901_- | SINE | Alu | Name=AluSc8 |
| ADediting_754419 | chr19_41349536_- | SINE | Alu | Name=AluSx1 |
| ADediting_754420 | chr19_41349588_- | SINE | Alu | Name=AluSx1 |
| ADediting_754421 | chr19_41349591_- | SINE | Alu | Name=AluSx1 |
| ADediting_754422 | chr19_41349594_- | SINE | Alu | Name=AluSx1 |
| ADediting_754423 | chr19_41349609_- | SINE | Alu | Name=AluSx1 |
| ADediting_754424 | chr19_41349635_- | SINE | Alu | Name=AluSx1 |
| ADediting_754425 | chr19_41349656_- | SINE | Alu | Name=AluSx1 |
| ADediting_754426 | chr19_41349670_- | SINE | Alu | Name=AluSx1 |
| ADediting_754427 | chr19_41349674_- | SINE | Alu | Name=AluSx1 |
| ADediting_754428 | chr19_41349681_- | SINE | Alu | Name=AluSx1 |
| ADediting_754429 | chr19_41349697_- | SINE | Alu | Name=AluSx1 |
| ADediting_754430 | chr19_41349735_- | SINE | Alu | Name=AluSx1 |
| ADediting_754431 | chr19_41349751_- | SINE | Alu | Name=AluSx1 |
| ADediting_754432 | chr19_41350416_- | SINE | Alu | Name=AluSx1 |
| ADediting_754433 | chr19_41350472_- | SINE | Alu | Name=AluSx1 |
| ADediting_754434 | chr19_41350478_- | SINE | Alu | Name=AluSx1 |
| ADediting_754435 | chr19_41350481_- | SINE | Alu | Name=AluSx1 |
| ADediting_1556202 | chr19_41330363_- | SINE | Alu | Name=AluJb |
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RNA A-to-I editing events in the alternative splicing sites for TGFB1 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for TGFB1 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for TGFB1 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for TGFB1 |
| RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. |
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| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_754327 | chr19_41330331_- | ENSG00000105329.10 | ENST00000221930.6 | TGFB1-201 | hsa-miR-4732-3p | chr19 | 41330329 | 41330335 | 7mer-m8 | 41330328 | 41330348 | 159 | -26.98 |
| ADediting_754327 | chr19_41330331_- | ENSG00000105329.10 | ENST00000221930.6 | TGFB1-201 | hsa-miR-6779-3p | chr19 | 41330327 | 41330333 | 7mer-m8 | 41330326 | 41330344 | 159 | -28.14 |
| ADediting_754327 | chr19_41330331_- | ENSG00000105329.10 | ENST00000221930.6 | TGFB1-201 | hsa-miR-7976 | chr19 | 41330328 | 41330334 | 7mer-m8 | 41330327 | 41330344 | 142 | -16.3 |
| ADediting_754330 | chr19_41330433_- | ENSG00000105329.10 | ENST00000221930.6 | TGFB1-201 | hsa-miR-4716-5p | chr19 | 41330432 | 41330438 | 7mer-m8 | 41330431 | 41330452 | 148 | -14.09 |
| ADediting_754330 | chr19_41330433_- | ENSG00000105329.10 | ENST00000221930.6 | TGFB1-201 | hsa-miR-6511a-3p | chr19 | 41330427 | 41330434 | 8mer-1a | 41330427 | 41330448 | 145 | -18.84 |
| ADediting_754330 | chr19_41330433_- | ENSG00000105329.10 | ENST00000221930.6 | TGFB1-201 | hsa-miR-6511b-3p | chr19 | 41330427 | 41330434 | 8mer-1a | 41330427 | 41330449 | 140 | -18.02 |
| ADediting_754331 | chr19_41330530_- | ENSG00000105329.10 | ENST00000221930.6 | TGFB1-201 | hsa-miR-1234-3p | chr19 | 41330530 | 41330536 | 7mer-m8 | 41330529 | 41330550 | 150 | -18.98 |
| ADediting_754331 | chr19_41330530_- | ENSG00000105329.10 | ENST00000221930.6 | TGFB1-201 | hsa-miR-7107-5p | chr19 | 41330530 | 41330536 | 7mer-m8 | 41330529 | 41330550 | 142 | -19.17 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_754326 | chr19_41330324_- | ENSG00000105329.10 | ENST00000221930.6 | TGFB1-201 | hsa-miR-1184 | chr19 | 41330323 | 41330329 | 7mer-m8 | 41330323 | 41330342 | 154 | -23.11 |
| ADediting_754326 | chr19_41330324_- | ENSG00000105329.10 | ENST00000221930.6 | TGFB1-201 | hsa-miR-7156-3p | chr19 | 41330324 | 41330330 | 7mer-m8 | 41330323 | 41330343 | 143 | -21.41 |
| ADediting_754327 | chr19_41330331_- | ENSG00000105329.10 | ENST00000221930.6 | TGFB1-201 | hsa-miR-10397-5p | chr19 | 41330329 | 41330335 | 7mer-m8 | 41330328 | 41330349 | 150 | -21.41 |
| ADediting_754328 | chr19_41330350_- | ENSG00000105329.10 | ENST00000221930.6 | TGFB1-201 | hsa-miR-1245a | chr19 | 41330348 | 41330354 | 7mer-m8 | 41330347 | 41330367 | 145 | -18.36 |
| ADediting_754331 | chr19_41330530_- | ENSG00000105329.10 | ENST00000221930.6 | TGFB1-201 | hsa-miR-4485-5p | chr19 | 41330525 | 41330531 | 7mer-m8 | 41330524 | 41330539 | 149 | -18.55 |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_527135 | chr16_24203190_+ | ENSG00000105329.10 | ENST00000221930.6 | TGFB1-201 | hsa-miR-1273h-3p | chr19 | 41330808 | 41330814 | 7mer-m8 | 41330807 | 41330828 | 140 | -15.1 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for TGFB1 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000221930.6 | protein_coding |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_754326 | ENST00000221930.6 | chr19_41330324_- | 2779 | -1195.90 | -1191.70 | -1201.70 |
| ADediting_754327 | ENST00000221930.6 | chr19_41330331_- | 2772 | -1192.40 | -1191.70 | -1201.70 |
| ADediting_754328 | ENST00000221930.6 | chr19_41330350_- | 2753 | -1191.70 | -1191.70 | -1201.70 |
| ADediting_1556202 | ENST00000221930.6 | chr19_41330363_- | 2740 | -1191.70 | -1191.70 | -1201.70 |
| ADediting_754329 | ENST00000221930.6 | chr19_41330364_- | 2739 | -1194.30 | -1191.70 | -1201.70 |
| ADediting_754330 | ENST00000221930.6 | chr19_41330433_- | 2670 | -1191.40 | -1191.70 | -1201.70 |
| ADediting_754331 | ENST00000221930.6 | chr19_41330530_- | 2573 | -1195.90 | -1191.70 | -1201.70 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for TGFB1 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | ADediting_754314 | chr19_41330069_- | 0.262982054773991 | 0.063768863957876 | 0.351708761607886 | -0.053070255573245 | 1.32176851504061e-14 | 0.418942122957668 |
| DLPFC | ADediting_754369 | chr19_41338588_- | 0.320376013824331 | 0.0566209897021555 | 0.439003477629331 | -0.0441100615475741 | 8.05490588995998e-11 | 0.358272106385634 |
| DLPFC | ADediting_754377 | chr19_41339211_- | 0.231793589826551 | -0.0681103730948136 | 0.00354839553638797 | -0.165131962240734 | 3.04940971893162e-11 | 0.365690081374603 |
| DLPFC | ADediting_754392 | chr19_41340556_- | 0.654906340915498 | 0.0254842602028483 | 0.1876956233376 | -0.0750223961264738 | 1.46979141909428e-17 | 0.459000479279622 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 0.00924028201418633 | 0.14762785237595 | 0.945113788693362 | -0.00392592156468161 | 1.09376785673092e-30 | 0.591872790441699 |
| AC | 1.26538975646553e-10 | 0.392293927971175 | 0.000172935076838051 | 0.235358506183453 | 2.28503018422403e-15 | 0.473395855587913 |
| PCC | 0.581276824063941 | 0.040154116251022 | 0.759771807298427 | -0.0222689331078777 | 1.57605530370347e-08 | 0.394887770481703 |
| CER | 6.19348691174943e-05 | 0.321019491880563 | 0.000161553984946036 | 0.303281500182852 | 2.72071733199362e-09 | 0.461758049287017 |
| TCX | 0.0183438596797051 | 0.192385951781853 | 0.0160125166290511 | -0.196387605134308 | 8.57582537974669e-08 | 0.420294685700595 |
| FP | 0.014568406550698 | 0.182847466400471 | 0.923052798193462 | 0.00729092147511379 | 7.41145549591067e-12 | 0.484315728391228 |
| IFG | 0.750329621424074 | 0.0669995309752887 | 0.397885934764718 | 0.176794002538647 | 0.000220902770032767 | 0.673979622420454 |
| PG | 0.00296037683588387 | -0.21676897679843 | 0.000908879347395811 | -0.241260389247921 | 2.14501975134404e-09 | 0.421192718750663 |
| STG | 0.0876022062966799 | -0.187530682426686 | 0.00773259452209513 | -0.288723945436143 | 0.000185514949469103 | 0.396905699405586 |
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Relation with AD stages for TGFB1 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 5.7780265159187e-05 | 0.376995434769041 |
| TCX | 7.29731820239925e-11 | 0.579929729081912 |
| PG | 5.64460432641226e-08 | 0.385247792087556 |
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RelatedDrugs for TGFB1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TGFB1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| TGFB1 | C0034069 | Pulmonary Fibrosis | 7 | CTD_human |
| TGFB1 | C0085786 | Hamman-Rich syndrome | 7 | CTD_human |
| TGFB1 | C0016059 | Fibrosis | 6 | CTD_human |
| TGFB1 | C1623038 | Cirrhosis | 6 | CTD_human |
| TGFB1 | C0023893 | Liver Cirrhosis, Experimental | 5 | CTD_human |
| TGFB1 | C0027626 | Neoplasm Invasiveness | 5 | CTD_human |
| TGFB1 | C0011989 | Camurati-Engelmann Syndrome | 4 | CTD_human;ORPHANET;UNIPROT |
| TGFB1 | C0017668 | Focal glomerulosclerosis | 3 | CTD_human |
| TGFB1 | C0022658 | Kidney Diseases | 3 | CTD_human |
| TGFB1 | C0024121 | Lung Neoplasms | 3 | CTD_human |
| TGFB1 | C0027627 | Neoplasm Metastasis | 3 | CTD_human |
| TGFB1 | C0027726 | Nephrotic Syndrome | 3 | CTD_human |
| TGFB1 | C0086432 | Hyalinosis, Segmental Glomerular | 3 | CTD_human |
| TGFB1 | C0242379 | Malignant neoplasm of lung | 3 | CTD_human |
| TGFB1 | C0002152 | Alloxan Diabetes | 2 | CTD_human |
| TGFB1 | C0004096 | Asthma | 2 | CTD_human |
| TGFB1 | C0005138 | Berylliosis | 2 | CTD_human |
| TGFB1 | C0011853 | Diabetes Mellitus, Experimental | 2 | CTD_human |
| TGFB1 | C0011881 | Diabetic Nephropathy | 2 | CTD_human |
| TGFB1 | C0017667 | Nodular glomerulosclerosis | 2 | CTD_human |
| TGFB1 | C0020517 | Hypersensitivity | 2 | CTD_human |
| TGFB1 | C0020538 | Hypertensive disease | 2 | CTD_human |
| TGFB1 | C0021368 | Inflammation | 2 | CTD_human |
| TGFB1 | C0033578 | Prostatic Neoplasms | 2 | CTD_human |
| TGFB1 | C0038433 | Streptozotocin Diabetes | 2 | CTD_human |
| TGFB1 | C0376358 | Malignant neoplasm of prostate | 2 | CTD_human |
| TGFB1 | C1527304 | Allergic Reaction | 2 | CTD_human |
| TGFB1 | C2350873 | Beryllium Disease | 2 | CTD_human |
| TGFB1 | C0000786 | Spontaneous abortion | 1 | CTD_human |
| TGFB1 | C0000822 | Abortion, Tubal | 1 | CTD_human |
| TGFB1 | C0001418 | Adenocarcinoma | 1 | CTD_human |
| TGFB1 | C0001787 | Osteoporosis, Age-Related | 1 | CTD_human |
| TGFB1 | C0003504 | Aortic Valve Insufficiency | 1 | CTD_human |
| TGFB1 | C0005398 | Cholestasis, Extrahepatic | 1 | CTD_human |
| TGFB1 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| TGFB1 | C0006111 | Brain Diseases | 1 | CTD_human |
| TGFB1 | C0006663 | Calcinosis | 1 | CTD_human |
| TGFB1 | C0007097 | Carcinoma | 1 | CTD_human |
| TGFB1 | C0007114 | Malignant neoplasm of skin | 1 | CTD_human |
| TGFB1 | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
| TGFB1 | C0007140 | Carcinosarcoma | 1 | CTD_human |
| TGFB1 | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
| TGFB1 | C0008925 | Cleft Palate | 1 | CTD_human |
| TGFB1 | C0009402 | Colorectal Carcinoma | 1 | CTD_human |
| TGFB1 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
| TGFB1 | C0010474 | Curling Ulcer | 1 | CTD_human |
| TGFB1 | C0011581 | Depressive disorder | 1 | PSYGENET |
| TGFB1 | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | CTD_human |
| TGFB1 | C0011882 | Diabetic Neuropathies | 1 | CTD_human |
| TGFB1 | C0013238 | Dry Eye Syndromes | 1 | CTD_human |
| TGFB1 | C0013264 | Muscular Dystrophy, Duchenne | 1 | CTD_human |
| TGFB1 | C0013295 | Duodenal Ulcer | 1 | CTD_human |
| TGFB1 | C0014544 | Epilepsy | 1 | CTD_human |
| TGFB1 | C0017661 | IGA Glomerulonephritis | 1 | CTD_human |
| TGFB1 | C0019189 | Hepatitis, Chronic | 1 | CTD_human |
| TGFB1 | C0019207 | Hepatoma, Morris | 1 | CTD_human |
| TGFB1 | C0019208 | Hepatoma, Novikoff | 1 | CTD_human |
| TGFB1 | C0019284 | Diaphragmatic Hernia | 1 | CTD_human |
| TGFB1 | C0020507 | Hyperplasia | 1 | CTD_human |
| TGFB1 | C0021290 | Neonatal disorder | 1 | CTD_human |
| TGFB1 | C0021390 | Inflammatory Bowel Diseases | 1 | CTD_human |
| TGFB1 | C0022660 | Kidney Failure, Acute | 1 | CTD_human |
| TGFB1 | C0022661 | Kidney Failure, Chronic | 1 | CTD_human |
| TGFB1 | C0023890 | Liver Cirrhosis | 1 | CTD_human |
| TGFB1 | C0023891 | Liver Cirrhosis, Alcoholic | 1 | CTD_human |
| TGFB1 | C0023904 | Liver Neoplasms, Experimental | 1 | CTD_human |
| TGFB1 | C0024115 | Lung diseases | 1 | CTD_human |
| TGFB1 | C0024117 | Chronic Obstructive Airway Disease | 1 | CTD_human |
| TGFB1 | C0026848 | Myopathy | 1 | CTD_human |
| TGFB1 | C0027051 | Myocardial Infarction | 1 | CTD_human |
| TGFB1 | C0028797 | Occupational Diseases | 1 | CTD_human |
| TGFB1 | C0029172 | Oral Submucous Fibrosis | 1 | CTD_human |
| TGFB1 | C0029456 | Osteoporosis | 1 | CTD_human |
| TGFB1 | C0029458 | Osteoporosis, Postmenopausal | 1 | CTD_human |
| TGFB1 | C0029459 | Osteoporosis, Senile | 1 | CTD_human |
| TGFB1 | C0030297 | Pancreatic Neoplasm | 1 | CTD_human |
| TGFB1 | C0030354 | Papilloma | 1 | CTD_human |
| TGFB1 | C0030848 | Peyronie Disease | 1 | CTD_human |
| TGFB1 | C0032226 | Pleural Diseases | 1 | CTD_human |
| TGFB1 | C0032285 | Pneumonia | 1 | CTD_human |
| TGFB1 | C0032300 | Lobar Pneumonia | 1 | CTD_human |
| TGFB1 | C0033687 | Proteinuria | 1 | CTD_human |
| TGFB1 | C0033975 | Psychotic Disorders | 1 | PSYGENET |
| TGFB1 | C0034067 | Pulmonary Emphysema | 1 | CTD_human |
| TGFB1 | C0034189 | Pyemia | 1 | CTD_human |
| TGFB1 | C0036202 | Sarcoidosis | 1 | CTD_human |
| TGFB1 | C0036341 | Schizophrenia | 1 | PSYGENET |
| TGFB1 | C0036690 | Septicemia | 1 | CTD_human |
| TGFB1 | C0037286 | Skin Neoplasms | 1 | CTD_human |
| TGFB1 | C0038454 | Cerebrovascular accident | 1 | CTD_human |
| TGFB1 | C0040028 | Thrombocythemia, Essential | 1 | CTD_human |
| TGFB1 | C0041948 | Uremia | 1 | CTD_human |
| TGFB1 | C0041956 | Ureteral obstruction | 1 | CTD_human |
| TGFB1 | C0042109 | Urticaria | 1 | CTD_human |
| TGFB1 | C0085584 | Encephalopathies | 1 | CTD_human |
| TGFB1 | C0086132 | Depressive Symptoms | 1 | PSYGENET |
| TGFB1 | C0086237 | Epilepsy, Cryptogenic | 1 | CTD_human |
| TGFB1 | C0086404 | Experimental Hepatoma | 1 | CTD_human |
| TGFB1 | C0149519 | Chronic Persistent Hepatitis | 1 | CTD_human |
| TGFB1 | C0158266 | Intervertebral Disc Degeneration | 1 | CTD_human |
| TGFB1 | C0205641 | Adenocarcinoma, Basal Cell | 1 | CTD_human |
| TGFB1 | C0205642 | Adenocarcinoma, Oxyphilic | 1 | CTD_human |
| TGFB1 | C0205643 | Carcinoma, Cribriform | 1 | CTD_human |
| TGFB1 | C0205644 | Carcinoma, Granular Cell | 1 | CTD_human |
| TGFB1 | C0205645 | Adenocarcinoma, Tubular | 1 | CTD_human |
| TGFB1 | C0205696 | Anaplastic carcinoma | 1 | CTD_human |
| TGFB1 | C0205697 | Carcinoma, Spindle-Cell | 1 | CTD_human |
| TGFB1 | C0205698 | Undifferentiated carcinoma | 1 | CTD_human |
| TGFB1 | C0205699 | Carcinomatosis | 1 | CTD_human |
| TGFB1 | C0205874 | Papilloma, Squamous Cell | 1 | CTD_human |
| TGFB1 | C0205875 | Papillomatosis | 1 | CTD_human |
| TGFB1 | C0221227 | Centriacinar Emphysema | 1 | CTD_human |
| TGFB1 | C0236018 | Aura | 1 | CTD_human |
| TGFB1 | C0239946 | Fibrosis, Liver | 1 | CTD_human |
| TGFB1 | C0241910 | Hepatitis, Autoimmune | 1 | CTD_human |
| TGFB1 | C0242488 | Acute Lung Injury | 1 | CTD_human |
| TGFB1 | C0243026 | Sepsis | 1 | CTD_human |
| TGFB1 | C0263628 | Tumoral calcinosis | 1 | CTD_human |
| TGFB1 | C0264393 | Panacinar Emphysema | 1 | CTD_human |
| TGFB1 | C0264423 | Asthma, Occupational | 1 | CTD_human |
| TGFB1 | C0265287 | Acromicric Dysplasia | 1 | CTD_human |
| TGFB1 | C0271673 | Symmetric Diabetic Proximal Motor Neuropathy | 1 | CTD_human |
| TGFB1 | C0271674 | Asymmetric Diabetic Proximal Motor Neuropathy | 1 | CTD_human |
| TGFB1 | C0271678 | Diabetic Mononeuropathy | 1 | CTD_human |
| TGFB1 | C0271680 | Diabetic Polyneuropathies | 1 | CTD_human |
| TGFB1 | C0271685 | Diabetic Amyotrophy | 1 | CTD_human |
| TGFB1 | C0271686 | Diabetic Autonomic Neuropathy | 1 | CTD_human |
| TGFB1 | C0346647 | Malignant neoplasm of pancreas | 1 | CTD_human |
| TGFB1 | C0349204 | Nonorganic psychosis | 1 | PSYGENET |
| TGFB1 | C0393835 | Diabetic Asymmetric Polyneuropathy | 1 | CTD_human |
| TGFB1 | C0400966 | Non-alcoholic Fatty Liver Disease | 1 | CTD_human |
| TGFB1 | C0455503 | H/O: depression | 1 | PSYGENET |
| TGFB1 | C0520463 | Chronic active hepatitis | 1 | CTD_human |
| TGFB1 | C0521174 | Microcalcification | 1 | CTD_human |
| TGFB1 | C0521607 | Peritoneal Fibrosis | 1 | CTD_human |
| TGFB1 | C0524611 | Cryptogenic Chronic Hepatitis | 1 | CTD_human |
| TGFB1 | C0525045 | Mood Disorders | 1 | PSYGENET |
| TGFB1 | C0553980 | Endomyocardial Fibrosis | 1 | CTD_human |
| TGFB1 | C0600519 | Ventricular Remodeling | 1 | CTD_human |
| TGFB1 | C0600520 | Left Ventricle Remodeling | 1 | CTD_human |
| TGFB1 | C0751074 | Diabetic Neuralgia | 1 | CTD_human |
| TGFB1 | C0751111 | Awakening Epilepsy | 1 | CTD_human |
| TGFB1 | C0751406 | Post-Traumatic Osteoporosis | 1 | CTD_human |
| TGFB1 | C0751956 | Acute Cerebrovascular Accidents | 1 | CTD_human |
| TGFB1 | C0878576 | Posterior Leukoencephalopathy Syndrome | 1 | CTD_human |
| TGFB1 | C0887898 | Experimental Lung Inflammation | 1 | CTD_human |
| TGFB1 | C0917713 | Becker Muscular Dystrophy | 1 | CTD_human |
| TGFB1 | C1527249 | Colorectal Cancer | 1 | CTD_human |
| TGFB1 | C1527303 | Chronic Airflow Obstruction | 1 | CTD_human |
| TGFB1 | C1565662 | Acute Kidney Insufficiency | 1 | CTD_human |
| TGFB1 | C1719672 | Severe Sepsis | 1 | CTD_human |
| TGFB1 | C1837218 | Cleft palate, isolated | 1 | CTD_human |
| TGFB1 | C1876165 | Copper-Overload Cirrhosis | 1 | CTD_human |
| TGFB1 | C2239176 | Liver carcinoma | 1 | CTD_human |
| TGFB1 | C2350878 | Focal Emphysema | 1 | CTD_human |
| TGFB1 | C2609414 | Acute kidney injury | 1 | CTD_human |
| TGFB1 | C2717759 | Degenerative Intervertebral Discs | 1 | CTD_human |
| TGFB1 | C2717859 | Peritoneal Sclerosis | 1 | CTD_human |
| TGFB1 | C2717860 | Encapsulating Peritoneal Sclerosis | 1 | CTD_human |
| TGFB1 | C3160858 | Posterior reversible encephalopathy syndrome | 1 | CTD_human |
| TGFB1 | C3241937 | Nonalcoholic Steatohepatitis | 1 | CTD_human |
| TGFB1 | C3489628 | Thrombocytosis, Autosomal Dominant | 1 | CTD_human |
| TGFB1 | C3489726 | Geleophysic dysplasia | 1 | CTD_human |
| TGFB1 | C3542021 | Duchenne and Becker Muscular Dystrophy | 1 | CTD_human |
| TGFB1 | C3714636 | Pneumonitis | 1 | CTD_human |
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