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Center for Computational Systems Medicine
Soverview

Gene summary

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RNA A-to-I events

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Differntial gene expression between RNA A-to-I edited versus non-edited samples

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Protein coding region RNA A-to-I editings

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The effects of the RNA editing to the miRNA binding sites

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The effects of the RNA editing to the stability of the RNA structures

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Relation with ADAR

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Relation with AD stages

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Related drugs with this gene

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Related diseases with this gene


Gene summary for TCTA

check button Gene summary
Gene informationGene symbol

TCTA

Gene ID

6988

Gene nameT cell leukemia translocation altered
Synonyms-
Cytomap

3p21.31

Type of geneprotein-coding
DescriptionT-cell leukemia translocation-altered gene proteinT-cell leukemia translocation-associated gene protein
Modification date20200313
UniProtAcc

P57738,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
TCTA

GO:0045671

negative regulation of osteoclast differentiation

19560569

TCTA

GO:0072675

osteoclast fusion

19560569


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RNA A-to-I events for TCTA

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_1075676(49414058, +), ADediting_1075677(49414309, +), ADediting_1075678(49414413, +), ADediting_1075679(49414414, +), ADediting_1075680(49415239, +), ADediting_1075681(49415253, +), ADediting_1075682(49415261, +), ADediting_1075683(49415262, +), ADediting_1075684(49415267, +), ADediting_1075685(49415268, +), ADediting_1075686(49415288, +), ADediting_1075687(49415292, +), ADediting_1075688(49415305, +), ADediting_1075689(49415340, +), ADediting_1075690(49415345, +), ADediting_1075691(49415351, +), ADediting_1075692(49415354, +), ADediting_1075693(49415355, +), ADediting_1075694(49415356, +), ADediting_1075695(49415357, +), ADediting_1075696(49415358, +), ADediting_1075697(49415363, +), ADediting_1075698(49415364, +), ADediting_1075699(49415365, +), ADediting_1075700(49415366, +), ADediting_1075701(49415369, +), ADediting_1075702(49415385, +), ADediting_1075703(49415387, +), ADediting_1075704(49415389, +), ADediting_1075705(49415392, +), ADediting_1075706(49415395, +), ADediting_1075707(49415396, +), ADediting_1075708(49415409, +), ADediting_1075709(49415419, +), ADediting_1075710(49415422, +), ADediting_1075711(49415444, +), ADediting_1075712(49415448, +), ADediting_1075713(49415457, +), ADediting_1075714(49415465, +), ADediting_1075715(49415466, +), ADediting_1075716(49415468, +), ADediting_1075717(49415486, +), ADediting_1574961(49415300, +), ADediting_1574962(49415329, +), ADediting_1574963(49415437, +), ADediting_1647868(49415362, +), ADediting_1647869(49415503, +),

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RNA editing positional annotations for TCTA using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_1075676chr3_49414058_+intronic
ADediting_1075677chr3_49414309_+intronic
ADediting_1075678chr3_49414413_+intronic
ADediting_1075679chr3_49414414_+intronic
ADediting_1075680chr3_49415239_+UTR3
ADediting_1075681chr3_49415253_+UTR3
ADediting_1075682chr3_49415261_+UTR3
ADediting_1075683chr3_49415262_+UTR3
ADediting_1075684chr3_49415267_+UTR3
ADediting_1075685chr3_49415268_+UTR3
ADediting_1075686chr3_49415288_+UTR3
ADediting_1075687chr3_49415292_+UTR3
ADediting_1075688chr3_49415305_+UTR3
ADediting_1075689chr3_49415340_+UTR3
ADediting_1075690chr3_49415345_+UTR3
ADediting_1075691chr3_49415351_+UTR3
ADediting_1075692chr3_49415354_+UTR3
ADediting_1075693chr3_49415355_+UTR3
ADediting_1075694chr3_49415356_+UTR3
ADediting_1075695chr3_49415357_+UTR3
ADediting_1075696chr3_49415358_+UTR3
ADediting_1075697chr3_49415363_+UTR3
ADediting_1075698chr3_49415364_+UTR3
ADediting_1075699chr3_49415365_+UTR3
ADediting_1075700chr3_49415366_+UTR3
ADediting_1075701chr3_49415369_+UTR3
ADediting_1075702chr3_49415385_+UTR3
ADediting_1075703chr3_49415387_+UTR3
ADediting_1075704chr3_49415389_+UTR3
ADediting_1075705chr3_49415392_+UTR3
ADediting_1075706chr3_49415395_+UTR3
ADediting_1075707chr3_49415396_+UTR3
ADediting_1075708chr3_49415409_+UTR3
ADediting_1075709chr3_49415419_+UTR3
ADediting_1075710chr3_49415422_+UTR3
ADediting_1075711chr3_49415444_+UTR3
ADediting_1075712chr3_49415448_+UTR3
ADediting_1075713chr3_49415457_+UTR3
ADediting_1075714chr3_49415465_+UTR3
ADediting_1075715chr3_49415466_+UTR3
ADediting_1075716chr3_49415468_+UTR3
ADediting_1075717chr3_49415486_+UTR3
ADediting_1574961chr3_49415300_+UTR3
ADediting_1574962chr3_49415329_+UTR3
ADediting_1574963chr3_49415437_+UTR3
ADediting_1647868chr3_49415362_+UTR3
ADediting_1647869chr3_49415503_+UTR3

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_1075676chr3_49414058_+SINEAluName=AluSz
ADediting_1075677chr3_49414309_+SINEAluName=AluSq2
ADediting_1075678chr3_49414413_+SINEAluName=AluSq2
ADediting_1075679chr3_49414414_+SINEAluName=AluSq2
ADediting_1075680chr3_49415239_+SINEAluName=AluSg
ADediting_1075681chr3_49415253_+SINEAluName=AluSg
ADediting_1075682chr3_49415261_+SINEAluName=AluSg
ADediting_1075683chr3_49415262_+SINEAluName=AluSg
ADediting_1075684chr3_49415267_+SINEAluName=AluSg
ADediting_1075685chr3_49415268_+SINEAluName=AluSg
ADediting_1075686chr3_49415288_+SINEAluName=AluSg
ADediting_1075687chr3_49415292_+SINEAluName=AluSg
ADediting_1075688chr3_49415305_+SINEAluName=AluSg
ADediting_1075689chr3_49415340_+SINEAluName=AluSg
ADediting_1075690chr3_49415345_+SINEAluName=AluSg
ADediting_1075691chr3_49415351_+SINEAluName=AluSg
ADediting_1075692chr3_49415354_+SINEAluName=AluSg
ADediting_1075693chr3_49415355_+SINEAluName=AluSg
ADediting_1075694chr3_49415356_+SINEAluName=AluSg
ADediting_1075695chr3_49415357_+SINEAluName=AluSg
ADediting_1075696chr3_49415358_+SINEAluName=AluSg
ADediting_1075697chr3_49415363_+SINEAluName=AluSg
ADediting_1075698chr3_49415364_+SINEAluName=AluSg
ADediting_1075699chr3_49415365_+SINEAluName=AluSg
ADediting_1075700chr3_49415366_+SINEAluName=AluSg
ADediting_1075701chr3_49415369_+SINEAluName=AluSg
ADediting_1075702chr3_49415385_+SINEAluName=AluSg
ADediting_1075703chr3_49415387_+SINEAluName=AluSg
ADediting_1075704chr3_49415389_+SINEAluName=AluSg
ADediting_1075705chr3_49415392_+SINEAluName=AluSg
ADediting_1075706chr3_49415395_+SINEAluName=AluSg
ADediting_1075707chr3_49415396_+SINEAluName=AluSg
ADediting_1075708chr3_49415409_+SINEAluName=AluSg
ADediting_1075709chr3_49415419_+SINEAluName=AluSg
ADediting_1075710chr3_49415422_+SINEAluName=AluSg
ADediting_1075711chr3_49415444_+SINEAluName=AluSg
ADediting_1075712chr3_49415448_+SINEAluName=AluSg
ADediting_1075713chr3_49415457_+SINEAluName=AluSg
ADediting_1075714chr3_49415465_+SINEAluName=AluSg
ADediting_1075715chr3_49415466_+SINEAluName=AluSg
ADediting_1075716chr3_49415468_+SINEAluName=AluSg
ADediting_1075717chr3_49415486_+SINEAluName=AluSg
ADediting_1574961chr3_49415300_+SINEAluName=AluSg
ADediting_1574962chr3_49415329_+SINEAluName=AluSg
ADediting_1574963chr3_49415437_+SINEAluName=AluSg
ADediting_1647868chr3_49415362_+SINEAluName=AluSg
ADediting_1647869chr3_49415503_+SINEAluName=AluSg

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RNA A-to-I editing events in the alternative splicing sites for TCTA

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for TCTA

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
boxplot
boxplot
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
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check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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ADeditome IDChrPositoingSkipped exonENSGENSTs