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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for CAPN15 |
 Gene summary |
| Gene information | Gene symbol | CAPN15 | Gene ID | 6650 |
| Gene name | calpain 15 | |
| Synonyms | SOLH | |
| Cytomap | 16p13.3 | |
| Type of gene | protein-coding | |
| Description | calpain-15small optic lobes homolog | |
| Modification date | 20200313 | |
| UniProtAcc | O75808, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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RNA A-to-I events for CAPN15 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_545408(531738, +), ADediting_545477(531985, +), ADediting_545487(532007, +), ADediting_545513(532119, +), ADediting_545514(532120, +), ADediting_545518(532133, +), ADediting_545520(532160, +), ADediting_545521(532161, +), ADediting_545522(532215, +), ADediting_545530(532434, +), ADediting_545531(532435, +), ADediting_545549(532487, +), ADediting_545683(533142, +), ADediting_545939(536503, +), ADediting_545940(536640, +), ADediting_546003(537389, +), ADediting_546125(539032, +), ADediting_546389(542605, +), ADediting_546390(542611, +), ADediting_546391(542627, +), ADediting_546392(542641, +), ADediting_546393(542643, +), ADediting_546394(542655, +), ADediting_546395(542657, +), ADediting_546396(542662, +), ADediting_546397(542667, +), ADediting_546398(542688, +), ADediting_546399(542705, +), ADediting_546400(542729, +), ADediting_546401(542798, +), ADediting_546402(542799, +), ADediting_546403(542821, +), ADediting_546404(542928, +), ADediting_546405(542930, +), ADediting_546406(542931, +), ADediting_546407(542996, +), ADediting_546408(543001, +), ADediting_546409(543016, +), ADediting_546410(543095, +), ADediting_546411(543118, +), ADediting_1543072(536478, +), ADediting_1543073(536698, +), ADediting_1543079(542607, +), ADediting_1543080(542674, +), ADediting_1543081(542924, +), ADediting_1543082(543000, +), |
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RNA editing positional annotations for CAPN15 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_545408 | chr16_531738_+ | intronic |
| ADediting_545477 | chr16_531985_+ | intronic |
| ADediting_545487 | chr16_532007_+ | intronic |
| ADediting_545513 | chr16_532119_+ | intronic |
| ADediting_545514 | chr16_532120_+ | intronic |
| ADediting_545518 | chr16_532133_+ | intronic |
| ADediting_545520 | chr16_532160_+ | intronic |
| ADediting_545521 | chr16_532161_+ | intronic |
| ADediting_545522 | chr16_532215_+ | intronic |
| ADediting_545530 | chr16_532434_+ | intronic |
| ADediting_545531 | chr16_532435_+ | intronic |
| ADediting_545549 | chr16_532487_+ | intronic |
| ADediting_545683 | chr16_533142_+ | intronic |
| ADediting_545939 | chr16_536503_+ | intronic |
| ADediting_545940 | chr16_536640_+ | intronic |
| ADediting_546003 | chr16_537389_+ | intronic |
| ADediting_546125 | chr16_539032_+ | intronic |
| ADediting_546389 | chr16_542605_+ | intronic |
| ADediting_546390 | chr16_542611_+ | intronic |
| ADediting_546391 | chr16_542627_+ | intronic |
| ADediting_546392 | chr16_542641_+ | intronic |
| ADediting_546393 | chr16_542643_+ | intronic |
| ADediting_546394 | chr16_542655_+ | intronic |
| ADediting_546395 | chr16_542657_+ | intronic |
| ADediting_546396 | chr16_542662_+ | intronic |
| ADediting_546397 | chr16_542667_+ | intronic |
| ADediting_546398 | chr16_542688_+ | intronic |
| ADediting_546399 | chr16_542705_+ | intronic |
| ADediting_546400 | chr16_542729_+ | intronic |
| ADediting_546401 | chr16_542798_+ | intronic |
| ADediting_546402 | chr16_542799_+ | intronic |
| ADediting_546403 | chr16_542821_+ | intronic |
| ADediting_546404 | chr16_542928_+ | intronic |
| ADediting_546405 | chr16_542930_+ | intronic |
| ADediting_546406 | chr16_542931_+ | intronic |
| ADediting_546407 | chr16_542996_+ | intronic |
| ADediting_546408 | chr16_543001_+ | intronic |
| ADediting_546409 | chr16_543016_+ | intronic |
| ADediting_546410 | chr16_543095_+ | intronic |
| ADediting_546411 | chr16_543118_+ | intronic |
| ADediting_1543072 | chr16_536478_+ | intronic |
| ADediting_1543073 | chr16_536698_+ | intronic |
| ADediting_1543079 | chr16_542607_+ | intronic |
| ADediting_1543080 | chr16_542674_+ | intronic |
| ADediting_1543081 | chr16_542924_+ | intronic |
| ADediting_1543082 | chr16_543000_+ | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_545477 | chr16_531985_+ | SINE | Alu | Name=AluSx |
| ADediting_545487 | chr16_532007_+ | SINE | Alu | Name=AluSx |
| ADediting_545513 | chr16_532119_+ | SINE | Alu | Name=AluSx |
| ADediting_545514 | chr16_532120_+ | SINE | Alu | Name=AluSx |
| ADediting_545518 | chr16_532133_+ | SINE | Alu | Name=AluSx |
| ADediting_545520 | chr16_532160_+ | SINE | Alu | Name=AluSx |
| ADediting_545521 | chr16_532161_+ | SINE | Alu | Name=AluSx |
| ADediting_545522 | chr16_532215_+ | SINE | Alu | Name=AluSx |
| ADediting_545530 | chr16_532434_+ | SINE | Alu | Name=AluSz6 |
| ADediting_545531 | chr16_532435_+ | SINE | Alu | Name=AluSz6 |
| ADediting_545549 | chr16_532487_+ | SINE | Alu | Name=AluSz6 |
| ADediting_545683 | chr16_533142_+ | SINE | Alu | Name=AluSx1 |
| ADediting_545939 | chr16_536503_+ | SINE | Alu | Name=AluSg4 |
| ADediting_545940 | chr16_536640_+ | SINE | Alu | Name=AluSg4 |
| ADediting_546125 | chr16_539032_+ | SINE | Alu | Name=AluJr4 |
| ADediting_546389 | chr16_542605_+ | SINE | Alu | Name=AluJb |
| ADediting_546390 | chr16_542611_+ | SINE | Alu | Name=AluJb |
| ADediting_546391 | chr16_542627_+ | SINE | Alu | Name=AluJb |
| ADediting_546392 | chr16_542641_+ | SINE | Alu | Name=AluJb |
| ADediting_546393 | chr16_542643_+ | SINE | Alu | Name=AluJb |
| ADediting_546394 | chr16_542655_+ | SINE | Alu | Name=AluJb |
| ADediting_546395 | chr16_542657_+ | SINE | Alu | Name=AluJb |
| ADediting_546396 | chr16_542662_+ | SINE | Alu | Name=AluJb |
| ADediting_546397 | chr16_542667_+ | SINE | Alu | Name=AluJb |
| ADediting_546398 | chr16_542688_+ | SINE | Alu | Name=AluJb |
| ADediting_546399 | chr16_542705_+ | SINE | Alu | Name=AluJb |
| ADediting_546400 | chr16_542729_+ | SINE | Alu | Name=AluJb |
| ADediting_546401 | chr16_542798_+ | SINE | Alu | Name=AluSx1 |
| ADediting_546402 | chr16_542799_+ | SINE | Alu | Name=AluSx1 |
| ADediting_546403 | chr16_542821_+ | SINE | Alu | Name=AluSx1 |
| ADediting_546404 | chr16_542928_+ | SINE | Alu | Name=AluSx1 |
| ADediting_546405 | chr16_542930_+ | SINE | Alu | Name=AluSx1 |
| ADediting_546406 | chr16_542931_+ | SINE | Alu | Name=AluSx1 |
| ADediting_546407 | chr16_542996_+ | SINE | Alu | Name=AluSx1 |
| ADediting_546408 | chr16_543001_+ | SINE | Alu | Name=AluSx1 |
| ADediting_546409 | chr16_543016_+ | SINE | Alu | Name=AluSx1 |
| ADediting_546410 | chr16_543095_+ | SINE | Alu | Name=AluJb |
| ADediting_546411 | chr16_543118_+ | SINE | Alu | Name=AluJb |
| ADediting_1543072 | chr16_536478_+ | SINE | Alu | Name=AluSg4 |
| ADediting_1543073 | chr16_536698_+ | SINE | Alu | Name=AluSg4 |
| ADediting_1543079 | chr16_542607_+ | SINE | Alu | Name=AluJb |
| ADediting_1543080 | chr16_542674_+ | SINE | Alu | Name=AluJb |
| ADediting_1543081 | chr16_542924_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1543082 | chr16_543000_+ | SINE | Alu | Name=AluSx1 |
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RNA A-to-I editing events in the alternative splicing sites for CAPN15 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| A5SS | ADediting_546003 | chr16_537389_+ | 537384:537392 | 5ss | 3i | CTGGTAGGA | 6.77 | CTGGTGGGA | 3.33 |
| A5SS | ADediting_546003 | chr16_537389_+ | 537384:537392 | 5ss | 3i | CTGGTAGGA | 6.77 | CTGGTGGGA | 3.33 |
| ES | ADediting_546003 | chr16_537389_+ | 537384:537392 | 5ss | 3i | CTGGTAGGA | 6.77 | CTGGTGGGA | 3.33 |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for CAPN15 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for CAPN15 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for CAPN15 |
| RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. |
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| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_546003 | chr16_537389_+ | ENSG00000103326.12 | ENST00000567216.5 | CAPN15-205 | hsa-miR-1260a | chr16 | 537386 | 537392 | 7mer-m8 | 537377 | 537393 | 142 | -21.16 |
| ADediting_546003 | chr16_537389_+ | ENSG00000103326.12 | ENST00000567216.5 | CAPN15-205 | hsa-miR-1260b | chr16 | 537386 | 537392 | 7mer-m8 | 537376 | 537393 | 150 | -22.46 |
| ADediting_546003 | chr16_537389_+ | ENSG00000103326.12 | ENST00000567216.5 | CAPN15-205 | hsa-miR-4733-3p | chr16 | 537383 | 537389 | 7mer-m8 | 537369 | 537390 | 156 | -27.67 |
| ADediting_546003 | chr16_537389_+ | ENSG00000103326.12 | ENST00000567216.5 | CAPN15-205 | hsa-miR-532-3p | chr16 | 537387 | 537393 | 7mer-m8 | 537372 | 537394 | 147 | -27.92 |
| ADediting_546003 | chr16_537389_+ | ENSG00000103326.12 | ENST00000568402.1 | CAPN15-206 | hsa-miR-1260a | chr16 | 537386 | 537392 | 7mer-m8 | 537377 | 537393 | 142 | -21.16 |
| ADediting_546003 | chr16_537389_+ | ENSG00000103326.12 | ENST00000568402.1 | CAPN15-206 | hsa-miR-1260b | chr16 | 537386 | 537392 | 7mer-m8 | 537376 | 537393 | 150 | -22.46 |
| ADediting_546003 | chr16_537389_+ | ENSG00000103326.12 | ENST00000568402.1 | CAPN15-206 | hsa-miR-4733-3p | chr16 | 537383 | 537389 | 7mer-m8 | 537369 | 537390 | 156 | -27.67 |
| ADediting_546003 | chr16_537389_+ | ENSG00000103326.12 | ENST00000568402.1 | CAPN15-206 | hsa-miR-532-3p | chr16 | 537387 | 537393 | 7mer-m8 | 537372 | 537394 | 147 | -27.92 |
| ADediting_546125 | chr16_539032_+ | ENSG00000103326.12 | ENST00000567216.5 | CAPN15-205 | hsa-miR-5690 | chr16 | 539026 | 539032 | 7mer-m8 | 539013 | 539033 | 145 | -17.72 |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_527135 | chr16_24203190_+ | ENSG00000103326.12 | ENST00000219611.7 | CAPN15-201 | hsa-miR-1273h-3p | chr16 | 553867 | 553874 | 8mer-1a | 553854 | 553874 | 155 | -24.84 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for CAPN15 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000567216.5 | lncRNA |  |  |
| ENST00000568402.1 | lncRNA |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_546003 | ENST00000567216.5 | chr16_537389_+ | 705 | -1524.30 | -1520.00 | -1524.20 |
| ADediting_546125 | ENST00000567216.5 | chr16_539032_+ | 2348 | -1519.90 | -1520.00 | -1524.20 |
| ADediting_546003 | ENST00000568402.1 | chr16_537389_+ | 290 | -266.10 | -261.20 | -266.10 |
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Relation with ADAR for CAPN15 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| CER | ADediting_545940 | chr16_536640_+ | 0.00357846329979864 | 0.236450275810351 | 6.56590925950193e-06 | 0.358697520140039 | 0.0169731385483714 | 0.194681131905935 |
| CER | ADediting_546003 | chr16_537389_+ | 1.63480242926914e-06 | 0.379835264048703 | 1.32722587140045e-06 | 0.382879613086249 | 0.00105790351329124 | 0.264800452336391 |
| CER | ADediting_546391 | chr16_542627_+ | 5.15186998941814e-06 | 0.362494075062717 | 2.38053308747148e-07 | 0.406878794262507 | 0.00468303844173505 | 0.229735551640021 |
| CER | ADediting_546392 | chr16_542641_+ | 4.27851768988186e-05 | 0.327576721885584 | 0.000172720201966068 | 0.302002126621916 | 0.0100750554209757 | 0.209519743587725 |
| CER | ADediting_546394 | chr16_542655_+ | 0.000805849101998136 | 0.270727097028234 | 1.63267601517307e-05 | 0.343986130065951 | 0.0254205839958321 | 0.182474534493017 |
| CER | ADediting_546395 | chr16_542657_+ | 0.000538215388109401 | 0.279279729677258 | 0.000150125873273971 | 0.304679165307346 | 0.247226193474233 | 0.0950589805904174 |
| CER | ADediting_546397 | chr16_542667_+ | 2.64391175430053e-05 | 0.335891644603156 | 0.0136157325028736 | 0.201069912248989 | 0.307989273563153 | 0.0837922370042438 |
| CER | ADediting_546399 | chr16_542705_+ | 3.95693906875552e-07 | 0.399976383555324 | 0.000506500487382194 | 0.280543212799798 | 0.0178659906119758 | 0.193168686819995 |
| CER | ADediting_546406 | chr16_542931_+ | 8.3009265795763e-05 | 0.31571848492785 | 3.25797494068652e-05 | 0.332313361617476 | 0.104918153179837 | 0.132915789601301 |
| CER | ADediting_546408 | chr16_543001_+ | 3.95717842739319e-05 | 0.328941823129793 | 6.60632864950297e-05 | 0.319859951969768 | 0.0243560007125674 | 0.18380002125929 |
| CER | ADediting_546409 | chr16_543016_+ | 1.69595997043765e-05 | 0.343355651193063 | 9.0627401071359e-07 | 0.388373739813647 | 0.0194247422123784 | 0.190678669005405 |
| CER | ADediting_546411 | chr16_543118_+ | 2.37294932539879e-07 | 0.406921649100351 | 7.58570418012442e-08 | 0.421868128846778 | 0.00227146174166242 | 0.247397433716167 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 0.000456785991232233 | 0.19789196449195 | 2.27494764773043e-08 | 0.31082958606885 | 2.66720805885304e-11 | 0.366697982735629 |
| AC | 0.357902162206751 | 0.0583890481167698 | 0.0613669780118715 | 0.118499077528299 | 2.83392343129948e-07 | 0.317846636642127 |
| PCC | 0.000535547878140688 | 0.248221388510617 | 2.00980575678509e-05 | 0.303213538187406 | 5.05462718619542e-07 | 0.354021441888245 |
| CER | 0.0735473678563325 | 0.1465415412581 | 4.71881643484713e-10 | 0.480863962428866 | 0.000559608421979151 | 0.278465684480368 |
| TCX | 0.153078774257171 | 0.117234240147984 | 1.90164988830031e-05 | 0.341449537391045 | 0.0246607514285417 | 0.183415589470062 |
| FP | 0.0487683030637842 | 0.14793213079261 | 0.870839495155129 | -0.012272810188197 | 2.01190498201701e-09 | 0.43043294110303 |
| IFG | 0.000827782727524611 | 0.62543683424611 | 2.44100575652637e-06 | 0.791601845364732 | 0.0342332647072936 | 0.424912560837299 |
| STG | 0.00735921014802423 | 0.290446297438041 | 0.232345276379163 | 0.131718085197201 | 1.12029079917748e-08 | 0.574272069727712 |
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Relation with AD stages for CAPN15 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| CER | ADediting_546411 | chr16_543118_+ | 0.000410274467698436 | 0.334065044250146 |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 3.52594618033057e-05 | 0.386922182325346 |
| TCX | 6.90969608545573e-05 | 0.376643041133107 |
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RelatedDrugs for CAPN15 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CAPN15 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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