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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited versus non-edited samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with AD stages

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene


Gene summary for SNRPD2

check button Gene summary
Gene informationGene symbol

SNRPD2

Gene ID

6633

Gene namesmall nuclear ribonucleoprotein D2 polypeptide
SynonymsSMD2|SNRPD1|Sm-D2
Cytomap

19q13.32

Type of geneprotein-coding
Descriptionsmall nuclear ribonucleoprotein Sm D2small nuclear ribonucleoprotein D2 polypeptide 16.5kDasnRNP core protein D2
Modification date20200322
UniProtAcc

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
SNRPD2

GO:0000387

spliceosomal snRNP assembly

18984161

SNRPD2

GO:0000398

mRNA splicing, via spliceosome

28076346


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RNA A-to-I events for SNRPD2

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_763153(45688818, -), ADediting_763154(45688830, -), ADediting_763155(45688844, -), ADediting_763156(45688848, -), ADediting_763157(45688857, -), ADediting_763158(45688865, -), ADediting_763159(45688871, -), ADediting_763160(45688900, -), ADediting_763161(45688914, -), ADediting_763162(45688954, -), ADediting_763163(45688958, -), ADediting_763164(45688961, -), ADediting_763165(45689008, -), ADediting_763166(45689409, -), ADediting_763167(45689411, -), ADediting_763168(45689417, -), ADediting_763169(45689423, -), ADediting_763170(45689424, -), ADediting_763171(45689425, -), ADediting_763172(45689438, -), ADediting_763173(45689450, -), ADediting_763174(45689463, -), ADediting_763175(45689485, -), ADediting_763176(45689488, -), ADediting_763177(45689499, -), ADediting_763178(45689502, -), ADediting_763179(45689505, -), ADediting_763180(45689589, -), ADediting_763181(45689610, -), ADediting_763182(45689616, -), ADediting_763183(45689625, -), ADediting_763184(45689628, -), ADediting_763185(45689629, -), ADediting_763186(45689649, -), ADediting_763187(45689929, -), ADediting_763188(45689937, -), ADediting_763189(45689954, -), ADediting_763190(45689990, -), ADediting_763191(45689991, -), ADediting_763192(45690010, -), ADediting_763193(45690385, -), ADediting_763194(45690418, -), ADediting_763195(45690444, -), ADediting_763196(45690575, -), ADediting_763197(45690587, -), ADediting_763198(45690613, -), ADediting_763199(45690639, -), ADediting_763200(45690666, -), ADediting_763201(45690688, -), ADediting_763202(45690745, -), ADediting_763203(45690749, -), ADediting_763204(45690750, -), ADediting_763205(45690780, -), ADediting_763206(45690793, -), ADediting_763207(45691177, -), ADediting_763208(45691188, -), ADediting_763209(45691198, -), ADediting_763210(45691228, -), ADediting_763211(45691268, -), ADediting_763212(45691285, -), ADediting_763213(45691295, -), ADediting_763214(45691298, -), ADediting_763215(45691299, -), ADediting_763216(45691301, -), ADediting_763217(45691302, -), ADediting_763218(45691413, -), ADediting_763219(45691571, -), ADediting_763220(45691580, -), ADediting_763221(45691627, -), ADediting_763222(45691630, -), ADediting_763223(45691638, -), ADediting_1556779(45689706, -), ADediting_1556780(45690606, -), ADediting_1556781(45691165, -),

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RNA editing positional annotations for SNRPD2 using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_763153chr19_45688818_-intronic
ADediting_763154chr19_45688830_-intronic
ADediting_763155chr19_45688844_-intronic
ADediting_763156chr19_45688848_-intronic
ADediting_763157chr19_45688857_-intronic
ADediting_763158chr19_45688865_-intronic
ADediting_763159chr19_45688871_-intronic
ADediting_763160chr19_45688900_-intronic
ADediting_763161chr19_45688914_-intronic
ADediting_763162chr19_45688954_-intronic
ADediting_763163chr19_45688958_-intronic
ADediting_763164chr19_45688961_-intronic
ADediting_763165chr19_45689008_-intronic
ADediting_763166chr19_45689409_-intronic
ADediting_763167chr19_45689411_-intronic
ADediting_763168chr19_45689417_-intronic
ADediting_763169chr19_45689423_-intronic
ADediting_763170chr19_45689424_-intronic
ADediting_763171chr19_45689425_-intronic
ADediting_763172chr19_45689438_-intronic
ADediting_763173chr19_45689450_-intronic
ADediting_763174chr19_45689463_-intronic
ADediting_763175chr19_45689485_-intronic
ADediting_763176chr19_45689488_-intronic
ADediting_763177chr19_45689499_-intronic
ADediting_763178chr19_45689502_-intronic
ADediting_763179chr19_45689505_-intronic
ADediting_763180chr19_45689589_-intronic
ADediting_763181chr19_45689610_-intronic
ADediting_763182chr19_45689616_-intronic
ADediting_763183chr19_45689625_-intronic
ADediting_763184chr19_45689628_-intronic
ADediting_763185chr19_45689629_-intronic
ADediting_763186chr19_45689649_-intronic
ADediting_763187chr19_45689929_-intronic
ADediting_763188chr19_45689937_-intronic
ADediting_763189chr19_45689954_-intronic
ADediting_763190chr19_45689990_-intronic
ADediting_763191chr19_45689991_-intronic
ADediting_763192chr19_45690010_-intronic
ADediting_763193chr19_45690385_-intronic
ADediting_763194chr19_45690418_-intronic
ADediting_763195chr19_45690444_-intronic
ADediting_763196chr19_45690575_-UTR5
ADediting_763197chr19_45690587_-UTR5
ADediting_763198chr19_45690613_-UTR5
ADediting_763199chr19_45690639_-UTR5
ADediting_763200chr19_45690666_-UTR5
ADediting_763201chr19_45690688_-intronic
ADediting_763202chr19_45690745_-intronic
ADediting_763203chr19_45690749_-intronic
ADediting_763204chr19_45690750_-intronic
ADediting_763205chr19_45690780_-intronic
ADediting_763206chr19_45690793_-intronic
ADediting_763207chr19_45691177_-intronic
ADediting_763208chr19_45691188_-intronic
ADediting_763209chr19_45691198_-intronic
ADediting_763210chr19_45691228_-intronic
ADediting_763211chr19_45691268_-intronic
ADediting_763212chr19_45691285_-intronic
ADediting_763213chr19_45691295_-intronic
ADediting_763214chr19_45691298_-intronic
ADediting_763215chr19_45691299_-intronic
ADediting_763216chr19_45691301_-intronic
ADediting_763217chr19_45691302_-intronic
ADediting_763218chr19_45691413_-UTR5
ADediting_763219chr19_45691571_-UTR5
ADediting_763220chr19_45691580_-UTR5
ADediting_763221chr19_45691627_-UTR5
ADediting_763222chr19_45691630_-UTR5
ADediting_763223chr19_45691638_-UTR5
ADediting_1556779chr19_45689706_-intronic
ADediting_1556780chr19_45690606_-UTR5
ADediting_1556781chr19_45691165_-intronic

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_763153chr19_45688818_-SINEAluName=AluSc
ADediting_763154chr19_45688830_-SINEAluName=AluSc
ADediting_763155chr19_45688844_-SINEAluName=AluSc
ADediting_763156chr19_45688848_-SINEAluName=AluSc
ADediting_763157chr19_45688857_-SINEAluName=AluSc
ADediting_763158chr19_45688865_-SINEAluName=AluSc
ADediting_763159chr19_45688871_-SINEAluName=AluSc
ADediting_763160chr19_45688900_-SINEAluName=AluSc
ADediting_763161chr19_45688914_-SINEAluName=AluSc
ADediting_763162chr19_45688954_-SINEAluName=AluSc
ADediting_763163chr19_45688958_-SINEAluName=AluSc
ADediting_763164chr19_45688961_-SINEAluName=AluSc
ADediting_763165chr19_45689008_-SINEAluName=AluSc
ADediting_763166chr19_45689409_-SINEAluName=AluSz
ADediting_763167chr19_45689411_-SINEAluName=AluSz
ADediting_763168chr19_45689417_-SINEAluName=AluSz
ADediting_763169chr19_45689423_-SINEAluName=AluSz
ADediting_763170chr19_45689424_-SINEAluName=AluSz
ADediting_763171chr19_45689425_-SINEAluName=AluSz
ADediting_763172chr19_45689438_-SINEAluName=AluSz
ADediting_763173chr19_45689450_-SINEAluName=AluSz
ADediting_763174chr19_45689463_-SINEAluName=AluSz
ADediting_763175chr19_45689485_-SINEAluName=AluSz
ADediting_763176chr19_45689488_-SINEAluName=AluSz
ADediting_763177chr19_45689499_-SINEAluName=AluSz
ADediting_763178chr19_45689502_-SINEAluName=AluSz
ADediting_763179chr19_45689505_-SINEAluName=AluSz
ADediting_763180chr19_45689589_-SINEAluName=AluSz
ADediting_763181chr19_45689610_-SINEAluName=AluSz
ADediting_763182chr19_45689616_-SINEAluName=AluSz
ADediting_763183chr19_45689625_-SINEAluName=AluSz
ADediting_763184chr19_45689628_-SINEAluName=AluSz
ADediting_763185chr19_45689629_-SINEAluName=AluSz
ADediting_763186chr19_45689649_-SINEAluName=AluSz
ADediting_763187chr19_45689929_-SINEAluName=AluSx
ADediting_763188chr19_45689937_-SINEAluName=AluSx
ADediting_763189chr19_45689954_-SINEAluName=AluSx
ADediting_763190chr19_45689990_-SINEAluName=AluSx
ADediting_763191chr19_45689991_-SINEAluName=AluSx
ADediting_763192chr19_45690010_-SINEAluName=AluSx
ADediting_763193chr19_45690385_-SINEAluName=AluSx
ADediting_763194chr19_45690418_-SINEAluName=AluSx
ADediting_763195chr19_45690444_-SINEAluName=AluSx
ADediting_763196chr19_45690575_-SINEAluName=AluSx1
ADediting_763197chr19_45690587_-SINEAluName=AluSx1
ADediting_763198chr19_45690613_-SINEAluName=AluSx1
ADediting_763199chr19_45690639_-SINEAluName=AluSx1
ADediting_763200chr19_45690666_-SINEAluName=AluSx1
ADediting_763201chr19_45690688_-SINEAluName=AluSx1
ADediting_763202chr19_45690745_-SINEAluName=AluSx1
ADediting_763203chr19_45690749_-SINEAluName=AluSx1
ADediting_763204chr19_45690750_-SINEAluName=AluSx1
ADediting_763205chr19_45690780_-SINEAluName=AluSx1
ADediting_763206chr19_45690793_-SINEAluName=AluSx1
ADediting_763207chr19_45691177_-SINEAluName=AluSx1
ADediting_763208chr19_45691188_-SINEAluName=AluSx1
ADediting_763209chr19_45691198_-SINEAluName=AluSx1
ADediting_763210chr19_45691228_-SINEAluName=AluSx1
ADediting_763211chr19_45691268_-SINEAluName=AluSx1
ADediting_763212chr19_45691285_-SINEAluName=AluSx1
ADediting_763213chr19_45691295_-SINEAluName=AluSx1
ADediting_763214chr19_45691298_-SINEAluName=AluSx1
ADediting_763215chr19_45691299_-SINEAluName=AluSx1
ADediting_763216chr19_45691301_-SINEAluName=AluSx1
ADediting_763217chr19_45691302_-SINEAluName=AluSx1
ADediting_763218chr19_45691413_-SINEAluName=AluSx1
ADediting_763219chr19_45691571_-SINEAluName=FLAM_C
ADediting_763220chr19_45691580_-SINEAluName=FLAM_C
ADediting_763221chr19_45691627_-SINEAluName=FLAM_C
ADediting_763222chr19_45691630_-SINEAluName=FLAM_C
ADediting_763223chr19_45691638_-SINEAluName=FLAM_C
ADediting_1556779chr19_45689706_-SINEAluName=AluSz
ADediting_1556780chr19_45690606_-SINEAluName=AluSx1
ADediting_1556781chr19_45691165_-SINEAluName=AluSx1

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RNA A-to-I editing events in the alternative splicing sites for SNRPD2

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength
ESADediting_763197chr19_45690587_-45690583:456906053ss2iCCCGCCTCGACCTTCCAAAGTGC3.44CCCGCCTCGACCTTCCAAGGTGC-4.51
ESADediting_763200chr19_45690666_-45690662:456906843ss2iAACTTTCGTATTTTTAGTAGAGA1.68AACTTTCGTATTTTTAGTGGAGA-6.27
ESADediting_763200chr19_45690666_-45690665:456906873ss2eGCTAACTTTCGTATTTTTAGTAG4.07GCTAACTTTCGTATTTTTAGTGG5.39

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for SNRPD2

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
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check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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ADeditome IDChrPositoingSkipped exonENSGENSTs

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Protein coding region RNA A-to-I editings for SNRPD2

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for SNRPD2


check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1631458chr19_40282624_-ENSG00000125743.10ENST00000342669.7SNRPD2-201hsa-miR-641chr1945687513456875197mer-1a4568751345687536142-19.39
ADediting_1631458chr19_40282624_-ENSG00000125743.10ENST00000391932.7SNRPD2-202hsa-miR-641chr1945687513456875197mer-1a4568751345687536142-19.39
ADediting_1631458chr19_40282624_-ENSG00000125743.10ENST00000585392.2SNRPD2-203hsa-miR-641chr1945687513456875197mer-1a4568751345687536142-19.39
ADediting_1631458chr19_40282624_-ENSG00000125743.10ENST00000587367.5SNRPD2-204hsa-miR-641chr1945687513456875197mer-1a4568751345687536142-19.39
ADediting_1631458chr19_40282624_-ENSG00000125743.10ENST00000588301.5SNRPD2-206hsa-miR-641chr1945687513456875197mer-1a4568751345687536142-19.39
ADediting_1631458chr19_40282624_-ENSG00000125743.10ENST00000588599.5SNRPD2-207hsa-miR-641chr1945687513456875197mer-1a4568751345687536142-19.39
ADediting_1631458chr19_40282624_-ENSG00000125743.10ENST00000590212.1SNRPD2-208hsa-miR-641chr1945687513456875197mer-1a4568751345687536142-19.39

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for SNRPD2

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.
ENST00000587367.5protein_codingSoverviewSoverview
ENST00000588599.5protein_codingSoverviewSoverview

check button RNA A-to-I editing in miRNA.
ADeditom_IDENSTmir_IDEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in mRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI
ADediting_763196ENST00000587367.5chr19_45690575_-147-192.80-191.40-197.20
ADediting_763197ENST00000587367.5chr19_45690587_-135-197.60-191.40-197.20
ADediting_1556780ENST00000587367.5chr19_45690606_-116-191.60-191.40-197.20
ADediting_763198ENST00000587367.5chr19_45690613_-109-192.00-191.40-197.20
ADediting_763199ENST00000587367.5chr19_45690639_-83-191.10-191.40-197.20
ADediting_763200ENST00000587367.5chr19_45690666_-56-191.40-191.40-197.20
ADediting_763218ENST00000588599.5chr19_45691413_-359-263.00-260.80-269.10
ADediting_763219ENST00000588599.5chr19_45691571_-201-262.90-260.80-269.10
ADediting_763220ENST00000588599.5chr19_45691580_-192-262.00-260.80-269.10
ADediting_763221ENST00000588599.5chr19_45691627_-145-263.40-260.80-269.10
ADediting_763222ENST00000588599.5chr19_45691630_-142-263.50-260.80-269.10
ADediting_763223ENST00000588599.5chr19_45691638_-134-263.40-260.80-269.10

check button RNA A-to-I editing in lncRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for SNRPD2

check button Correlation between ADAR gene expression and RNA editing frequency
TissueADeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFCADediting_763165chr19_45689008_-0.0006251315272051570.1932163701255570.01016420716467920.1457853511578941.1926529790592e-090.336618860246234
CERADediting_763172chr19_45689438_-0.04976649022273360.1604963944872751.29176786234288e-050.3478394472805470.208681996953090.103238893225841
DLPFCADediting_763182chr19_45689616_-0.1806735681482440.07622941854957570.831221987483725-0.01215388274365694.3262755531859e-090.32564474975243
DLPFCADediting_763183chr19_45689625_-0.0005501017587671850.1951346898284520.5881940258042220.03086995270348772.9330888335678e-150.428276181418654
DLPFCADediting_763193chr19_45690385_-0.03391904940049290.1205140218308310.1726277732447540.07765582595875151.53243908270969e-090.334517564310195
DLPFCADediting_763205chr19_45690780_-0.04146839278686050.1158747359390110.3040666726412480.05855882864402031.00636299723785e-080.318210296260689
DLPFCADediting_763206chr19_45690793_-0.01327155563863860.1405190809414970.366262215957460.05148913494744541.10783942589858e-130.4052471338382

check button Correlation between ADAR gene expression and this gene's expression
TissueADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFC2.35765452324143e-310.5972586906620991.43614495307778e-520.7286828609445610.0003356108798968410.202384858182122
AC7.5996158236243e-590.8077494915138578.78290037051324e-490.762395560912133.59108299447474e-130.438504361617623
PCC1.35021523066433e-160.5515565799232151.28376941499405e-190.5942318804728840.1486911858392790.104896534586133
TCX4.35050952556361e-060.3651122558757925.49377974689649e-090.4537515904989150.0352136620459553-0.172100043326414
FP1.88997411304339e-070.3785321102957352.689051660988e-140.5302818995903230.0655930344330713-0.138313775278177
IFG0.0206171396997880.4602217427949780.06824347524541720.3705431841523950.0790801675423718-0.35779431617248
STG2.65682280954823e-130.6934320657676451.53819503621398e-100.62856394744520.249640763302494-0.127002244136781

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Relation with AD stages for SNRPD2

check button Correlation between AD stages and RNA editing frequency
TissueADeditomIDpositionP-valCoeff.

check button Correlation between AD stages and this gene's expression
TissueP-valCoeff.
PG4.24115907669428e-08-0.388566131665339

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RelatedDrugs for SNRPD2

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SNRPD2

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource