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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for AACS |
 Gene summary |
| Gene information | Gene symbol | AACS | Gene ID | 65985 |
| Gene name | acetoacetyl-CoA synthetase | |
| Synonyms | ACSF1|SUR-5 | |
| Cytomap | 12q24.31 | |
| Type of gene | protein-coding | |
| Description | acetoacetyl-CoA synthetaseacetoacetate-CoA ligaseacyl-CoA synthetase family member 1homolog of C. elegans supressor of ras 5 (sur-5)protein sur-5 homolog | |
| Modification date | 20200313 | |
| UniProtAcc | Q86V21, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
Top |
RNA A-to-I events for AACS |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
 |
| RNA editing frequencies across three data sets. |
 |
| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
 |
| RNA A-to-I editing events in AD. |
| ADediting_327438(125067651, +), ADediting_327439(125067808, +), ADediting_327440(125068201, +), ADediting_327441(125068202, +), ADediting_327442(125068210, +), ADediting_327443(125068219, +), ADediting_327444(125068302, +), ADediting_327445(125068384, +), ADediting_327446(125068920, +), ADediting_327447(125074319, +), ADediting_327448(125077001, +), ADediting_327449(125077020, +), ADediting_327450(125077037, +), ADediting_327451(125077047, +), ADediting_327452(125077049, +), ADediting_327453(125077053, +), ADediting_327454(125077323, +), ADediting_327455(125077333, +), ADediting_327456(125077389, +), ADediting_327457(125077778, +), ADediting_327458(125077848, +), ADediting_327459(125077850, +), ADediting_327460(125078655, +), ADediting_327461(125079131, +), ADediting_327462(125079418, +), ADediting_327463(125079494, +), ADediting_327464(125079511, +), ADediting_327465(125083677, +), ADediting_327466(125083685, +), ADediting_327467(125098161, +), ADediting_327468(125098168, +), ADediting_327469(125098175, +), ADediting_327470(125098251, +), ADediting_327471(125098252, +), ADediting_327472(125098272, +), ADediting_327473(125098283, +), ADediting_327474(125098521, +), ADediting_327475(125098532, +), ADediting_327476(125098545, +), ADediting_327477(125098632, +), ADediting_327478(125098649, +), ADediting_327479(125098725, +), ADediting_327480(125107783, +), ADediting_327481(125107784, +), ADediting_327482(125107842, +), ADediting_327483(125108768, +), ADediting_327484(125108797, +), ADediting_327485(125108925, +), ADediting_327486(125109163, +), ADediting_327487(125109232, +), ADediting_327488(125109257, +), ADediting_327489(125110094, +), ADediting_327490(125110120, +), ADediting_327491(125110270, +), ADediting_327492(125115360, +), ADediting_327493(125115402, +), ADediting_327494(125115534, +), ADediting_327495(125116544, +), ADediting_327496(125116550, +), ADediting_327497(125116557, +), ADediting_327498(125116568, +), ADediting_327499(125116603, +), ADediting_327500(125116605, +), ADediting_327501(125116629, +), ADediting_327502(125116739, +), ADediting_327503(125117068, +), ADediting_327504(125117156, +), ADediting_327505(125117183, +), ADediting_327506(125117202, +), ADediting_327507(125117263, +), ADediting_327508(125117287, +), ADediting_327509(125117293, +), ADediting_327510(125117294, +), ADediting_327511(125117321, +), ADediting_327512(125117708, +), ADediting_327513(125117715, +), ADediting_327514(125117730, +), ADediting_327515(125117731, +), ADediting_327516(125117757, +), ADediting_327517(125117785, +), ADediting_327518(125117837, +), ADediting_327519(125117869, +), ADediting_327520(125117873, +), ADediting_327521(125117890, +), ADediting_327522(125117904, +), ADediting_327523(125117909, +), ADediting_327524(125122386, +), ADediting_327525(125122416, +), ADediting_327526(125122522, +), ADediting_327527(125122523, +), ADediting_327528(125122549, +), ADediting_327529(125122558, +), ADediting_327530(125123731, +), ADediting_327531(125124081, +), ADediting_327532(125124111, +), ADediting_327533(125124125, +), ADediting_327534(125124130, +), ADediting_327535(125124133, +), ADediting_327536(125124166, +), ADediting_327537(125124174, +), ADediting_327538(125124205, +), ADediting_327539(125124210, +), ADediting_327540(125124220, +), ADediting_327541(125124252, +), ADediting_327542(125124281, +), ADediting_327543(125126601, +), ADediting_327544(125126603, +), ADediting_327545(125126646, +), ADediting_327546(125126649, +), ADediting_327547(125126656, +), ADediting_327548(125126661, +), ADediting_327549(125126681, +), ADediting_327550(125126682, +), ADediting_327551(125126686, +), ADediting_327552(125126694, +), ADediting_327553(125126711, +), ADediting_327554(125126715, +), ADediting_327555(125126721, +), ADediting_327556(125126817, +), ADediting_327557(125126818, +), ADediting_327558(125126830, +), ADediting_327559(125126857, +), ADediting_327560(125127019, +), ADediting_327561(125127020, +), ADediting_327562(125127032, +), ADediting_327563(125127036, +), ADediting_327564(125127046, +), ADediting_327565(125127055, +), ADediting_327566(125127060, +), ADediting_327567(125127061, +), ADediting_327568(125127075, +), ADediting_327569(125127131, +), ADediting_327570(125127467, +), ADediting_327571(125127468, +), ADediting_327572(125127503, +), ADediting_327573(125127505, +), ADediting_327574(125127516, +), ADediting_327575(125127571, +), ADediting_327576(125127581, +), ADediting_327577(125127627, +), ADediting_327578(125127641, +), ADediting_327579(125127683, +), ADediting_327580(125127706, +), ADediting_327581(125127712, +), ADediting_327582(125130408, +), ADediting_327583(125130961, +), ADediting_327584(125131011, +), ADediting_327585(125132116, +), ADediting_327586(125136212, +), ADediting_327587(125137225, +), ADediting_327588(125137248, +), ADediting_327589(125141423, +), ADediting_327590(125141453, +), ADediting_327591(125141470, +), ADediting_327592(125141475, +), ADediting_327593(125141483, +), ADediting_327594(125141536, +), ADediting_327595(125141540, +), ADediting_327596(125141543, +), ADediting_327597(125141546, +), ADediting_327598(125141550, +), ADediting_327599(125141574, +), ADediting_327600(125141590, +), ADediting_327601(125141618, +), ADediting_327602(125141641, +), ADediting_327603(125141642, +), ADediting_327604(125141718, +), ADediting_327605(125141720, +), ADediting_1531542(125137348, +), ADediting_1531543(125141478, +), ADediting_1612522(125083826, +), ADediting_1612523(125083834, +), ADediting_1612524(125084142, +), ADediting_1612525(125084152, +), ADediting_1612526(125098274, +), ADediting_1612527(125098299, +), ADediting_1612528(125098661, +), |
Top |
RNA editing positional annotations for AACS using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_327438 | chr12_125067651_+ | intronic |
| ADediting_327439 | chr12_125067808_+ | intronic |
| ADediting_327440 | chr12_125068201_+ | intronic |
| ADediting_327441 | chr12_125068202_+ | intronic |
| ADediting_327442 | chr12_125068210_+ | intronic |
| ADediting_327443 | chr12_125068219_+ | intronic |
| ADediting_327444 | chr12_125068302_+ | intronic |
| ADediting_327445 | chr12_125068384_+ | intronic |
| ADediting_327446 | chr12_125068920_+ | intronic |
| ADediting_327447 | chr12_125074319_+ | intronic |
| ADediting_327448 | chr12_125077001_+ | intronic |
| ADediting_327449 | chr12_125077020_+ | intronic |
| ADediting_327450 | chr12_125077037_+ | intronic |
| ADediting_327451 | chr12_125077047_+ | intronic |
| ADediting_327452 | chr12_125077049_+ | intronic |
| ADediting_327453 | chr12_125077053_+ | intronic |
| ADediting_327454 | chr12_125077323_+ | intronic |
| ADediting_327455 | chr12_125077333_+ | intronic |
| ADediting_327456 | chr12_125077389_+ | intronic |
| ADediting_327457 | chr12_125077778_+ | intronic |
| ADediting_327458 | chr12_125077848_+ | intronic |
| ADediting_327459 | chr12_125077850_+ | intronic |
| ADediting_327460 | chr12_125078655_+ | intronic |
| ADediting_327461 | chr12_125079131_+ | intronic |
| ADediting_327462 | chr12_125079418_+ | intronic |
| ADediting_327463 | chr12_125079494_+ | intronic |
| ADediting_327464 | chr12_125079511_+ | intronic |
| ADediting_327465 | chr12_125083677_+ | intronic |
| ADediting_327466 | chr12_125083685_+ | intronic |
| ADediting_327467 | chr12_125098161_+ | intronic |
| ADediting_327468 | chr12_125098168_+ | intronic |
| ADediting_327469 | chr12_125098175_+ | intronic |
| ADediting_327470 | chr12_125098251_+ | intronic |
| ADediting_327471 | chr12_125098252_+ | intronic |
| ADediting_327472 | chr12_125098272_+ | intronic |
| ADediting_327473 | chr12_125098283_+ | intronic |
| ADediting_327474 | chr12_125098521_+ | intronic |
| ADediting_327475 | chr12_125098532_+ | intronic |
| ADediting_327476 | chr12_125098545_+ | intronic |
| ADediting_327477 | chr12_125098632_+ | intronic |
| ADediting_327478 | chr12_125098649_+ | intronic |
| ADediting_327479 | chr12_125098725_+ | intronic |
| ADediting_327480 | chr12_125107783_+ | intronic |
| ADediting_327481 | chr12_125107784_+ | intronic |
| ADediting_327482 | chr12_125107842_+ | intronic |
| ADediting_327483 | chr12_125108768_+ | intronic |
| ADediting_327484 | chr12_125108797_+ | intronic |
| ADediting_327485 | chr12_125108925_+ | intronic |
| ADediting_327486 | chr12_125109163_+ | intronic |
| ADediting_327487 | chr12_125109232_+ | intronic |
| ADediting_327488 | chr12_125109257_+ | intronic |
| ADediting_327489 | chr12_125110094_+ | intronic |
| ADediting_327490 | chr12_125110120_+ | intronic |
| ADediting_327491 | chr12_125110270_+ | intronic |
| ADediting_327492 | chr12_125115360_+ | intronic |
| ADediting_327493 | chr12_125115402_+ | intronic |
| ADediting_327494 | chr12_125115534_+ | intronic |
| ADediting_327495 | chr12_125116544_+ | intronic |
| ADediting_327496 | chr12_125116550_+ | intronic |
| ADediting_327497 | chr12_125116557_+ | intronic |
| ADediting_327498 | chr12_125116568_+ | intronic |
| ADediting_327499 | chr12_125116603_+ | intronic |
| ADediting_327500 | chr12_125116605_+ | intronic |
| ADediting_327501 | chr12_125116629_+ | intronic |
| ADediting_327502 | chr12_125116739_+ | intronic |
| ADediting_327503 | chr12_125117068_+ | intronic |
| ADediting_327504 | chr12_125117156_+ | intronic |
| ADediting_327505 | chr12_125117183_+ | intronic |
| ADediting_327506 | chr12_125117202_+ | intronic |
| ADediting_327507 | chr12_125117263_+ | intronic |
| ADediting_327508 | chr12_125117287_+ | intronic |
| ADediting_327509 | chr12_125117293_+ | intronic |
| ADediting_327510 | chr12_125117294_+ | intronic |
| ADediting_327511 | chr12_125117321_+ | intronic |
| ADediting_327512 | chr12_125117708_+ | intronic |
| ADediting_327513 | chr12_125117715_+ | intronic |
| ADediting_327514 | chr12_125117730_+ | intronic |
| ADediting_327515 | chr12_125117731_+ | intronic |
| ADediting_327516 | chr12_125117757_+ | intronic |
| ADediting_327517 | chr12_125117785_+ | intronic |
| ADediting_327518 | chr12_125117837_+ | intronic |
| ADediting_327519 | chr12_125117869_+ | intronic |
| ADediting_327520 | chr12_125117873_+ | intronic |
| ADediting_327521 | chr12_125117890_+ | intronic |
| ADediting_327522 | chr12_125117904_+ | intronic |
| ADediting_327523 | chr12_125117909_+ | intronic |
| ADediting_327524 | chr12_125122386_+ | intronic |
| ADediting_327525 | chr12_125122416_+ | intronic |
| ADediting_327526 | chr12_125122522_+ | intronic |
| ADediting_327527 | chr12_125122523_+ | intronic |
| ADediting_327528 | chr12_125122549_+ | intronic |
| ADediting_327529 | chr12_125122558_+ | intronic |
| ADediting_327530 | chr12_125123731_+ | intronic |
| ADediting_327531 | chr12_125124081_+ | intronic |
| ADediting_327532 | chr12_125124111_+ | intronic |
| ADediting_327533 | chr12_125124125_+ | intronic |
| ADediting_327534 | chr12_125124130_+ | intronic |
| ADediting_327535 | chr12_125124133_+ | intronic |
| ADediting_327536 | chr12_125124166_+ | intronic |
| ADediting_327537 | chr12_125124174_+ | intronic |
| ADediting_327538 | chr12_125124205_+ | intronic |
| ADediting_327539 | chr12_125124210_+ | intronic |
| ADediting_327540 | chr12_125124220_+ | intronic |
| ADediting_327541 | chr12_125124252_+ | intronic |
| ADediting_327542 | chr12_125124281_+ | intronic |
| ADediting_327543 | chr12_125126601_+ | intronic |
| ADediting_327544 | chr12_125126603_+ | intronic |
| ADediting_327545 | chr12_125126646_+ | intronic |
| ADediting_327546 | chr12_125126649_+ | intronic |
| ADediting_327547 | chr12_125126656_+ | intronic |
| ADediting_327548 | chr12_125126661_+ | intronic |
| ADediting_327549 | chr12_125126681_+ | intronic |
| ADediting_327550 | chr12_125126682_+ | intronic |
| ADediting_327551 | chr12_125126686_+ | intronic |
| ADediting_327552 | chr12_125126694_+ | intronic |
| ADediting_327553 | chr12_125126711_+ | intronic |
| ADediting_327554 | chr12_125126715_+ | intronic |
| ADediting_327555 | chr12_125126721_+ | intronic |
| ADediting_327556 | chr12_125126817_+ | intronic |
| ADediting_327557 | chr12_125126818_+ | intronic |
| ADediting_327558 | chr12_125126830_+ | intronic |
| ADediting_327559 | chr12_125126857_+ | intronic |
| ADediting_327560 | chr12_125127019_+ | intronic |
| ADediting_327561 | chr12_125127020_+ | intronic |
| ADediting_327562 | chr12_125127032_+ | intronic |
| ADediting_327563 | chr12_125127036_+ | intronic |
| ADediting_327564 | chr12_125127046_+ | intronic |
| ADediting_327565 | chr12_125127055_+ | intronic |
| ADediting_327566 | chr12_125127060_+ | intronic |
| ADediting_327567 | chr12_125127061_+ | intronic |
| ADediting_327568 | chr12_125127075_+ | intronic |
| ADediting_327569 | chr12_125127131_+ | intronic |
| ADediting_327570 | chr12_125127467_+ | intronic |
| ADediting_327571 | chr12_125127468_+ | intronic |
| ADediting_327572 | chr12_125127503_+ | intronic |
| ADediting_327573 | chr12_125127505_+ | intronic |
| ADediting_327574 | chr12_125127516_+ | intronic |
| ADediting_327575 | chr12_125127571_+ | intronic |
| ADediting_327576 | chr12_125127581_+ | intronic |
| ADediting_327577 | chr12_125127627_+ | intronic |
| ADediting_327578 | chr12_125127641_+ | intronic |
| ADediting_327579 | chr12_125127683_+ | intronic |
| ADediting_327580 | chr12_125127706_+ | intronic |
| ADediting_327581 | chr12_125127712_+ | intronic |
| ADediting_327582 | chr12_125130408_+ | intronic |
| ADediting_327583 | chr12_125130961_+ | intronic |
| ADediting_327584 | chr12_125131011_+ | intronic |
| ADediting_327585 | chr12_125132116_+ | intronic |
| ADediting_327586 | chr12_125136212_+ | intronic |
| ADediting_327587 | chr12_125137225_+ | intronic |
| ADediting_327588 | chr12_125137248_+ | intronic |
| ADediting_327589 | chr12_125141423_+ | ncRNA_exonic |
| ADediting_327590 | chr12_125141453_+ | ncRNA_exonic |
| ADediting_327591 | chr12_125141470_+ | ncRNA_exonic |
| ADediting_327592 | chr12_125141475_+ | ncRNA_exonic |
| ADediting_327593 | chr12_125141483_+ | ncRNA_exonic |
| ADediting_327594 | chr12_125141536_+ | ncRNA_exonic |
| ADediting_327595 | chr12_125141540_+ | ncRNA_exonic |
| ADediting_327596 | chr12_125141543_+ | ncRNA_exonic |
| ADediting_327597 | chr12_125141546_+ | ncRNA_exonic |
| ADediting_327598 | chr12_125141550_+ | ncRNA_exonic |
| ADediting_327599 | chr12_125141574_+ | ncRNA_exonic |
| ADediting_327600 | chr12_125141590_+ | ncRNA_exonic |
| ADediting_327601 | chr12_125141618_+ | ncRNA_exonic |
| ADediting_327602 | chr12_125141641_+ | ncRNA_exonic |
| ADediting_327603 | chr12_125141642_+ | ncRNA_exonic |
| ADediting_327604 | chr12_125141718_+ | intronic |
| ADediting_327605 | chr12_125141720_+ | intronic |
| ADediting_1531542 | chr12_125137348_+ | intronic |
| ADediting_1531543 | chr12_125141478_+ | ncRNA_exonic |
| ADediting_1612522 | chr12_125083826_+ | intronic |
| ADediting_1612523 | chr12_125083834_+ | intronic |
| ADediting_1612524 | chr12_125084142_+ | intronic |
| ADediting_1612525 | chr12_125084152_+ | intronic |
| ADediting_1612526 | chr12_125098274_+ | intronic |
| ADediting_1612527 | chr12_125098299_+ | intronic |
| ADediting_1612528 | chr12_125098661_+ | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_327438 | chr12_125067651_+ | SINE | Alu | Name=AluSq10 |
| ADediting_327439 | chr12_125067808_+ | SINE | Alu | Name=AluSq10 |
| ADediting_327440 | chr12_125068201_+ | SINE | Alu | Name=AluJb |
| ADediting_327441 | chr12_125068202_+ | SINE | Alu | Name=AluJb |
| ADediting_327442 | chr12_125068210_+ | SINE | Alu | Name=AluJb |
| ADediting_327443 | chr12_125068219_+ | SINE | Alu | Name=AluJb |
| ADediting_327444 | chr12_125068302_+ | SINE | Alu | Name=AluJb |
| ADediting_327445 | chr12_125068384_+ | SINE | Alu | Name=AluJb |
| ADediting_327446 | chr12_125068920_+ | SINE | Alu | Name=AluSx3 |
| ADediting_327447 | chr12_125074319_+ | SINE | Alu | Name=AluJo |
| ADediting_327448 | chr12_125077001_+ | SINE | Alu | Name=AluJo |
| ADediting_327449 | chr12_125077020_+ | SINE | Alu | Name=AluJo |
| ADediting_327450 | chr12_125077037_+ | SINE | Alu | Name=AluJo |
| ADediting_327451 | chr12_125077047_+ | SINE | Alu | Name=AluJo |
| ADediting_327452 | chr12_125077049_+ | SINE | Alu | Name=AluJo |
| ADediting_327453 | chr12_125077053_+ | SINE | Alu | Name=AluJo |
| ADediting_327454 | chr12_125077323_+ | SINE | Alu | Name=AluY |
| ADediting_327455 | chr12_125077333_+ | SINE | Alu | Name=AluY |
| ADediting_327456 | chr12_125077389_+ | SINE | Alu | Name=AluY |
| ADediting_327457 | chr12_125077778_+ | SINE | Alu | Name=AluSx |
| ADediting_327458 | chr12_125077848_+ | SINE | Alu | Name=AluSx |
| ADediting_327459 | chr12_125077850_+ | SINE | Alu | Name=AluSx |
| ADediting_327460 | chr12_125078655_+ | SINE | Alu | Name=AluSx1 |
| ADediting_327461 | chr12_125079131_+ | LINE | L2 | Name=L2a |
| ADediting_327462 | chr12_125079418_+ | SINE | Alu | Name=AluJb |
| ADediting_327463 | chr12_125079494_+ | SINE | Alu | Name=AluJb |
| ADediting_327464 | chr12_125079511_+ | SINE | Alu | Name=AluJb |
| ADediting_327465 | chr12_125083677_+ | SINE | Alu | Name=AluSx1 |
| ADediting_327466 | chr12_125083685_+ | SINE | Alu | Name=AluSx1 |
| ADediting_327467 | chr12_125098161_+ | SINE | Alu | Name=AluJb |
| ADediting_327468 | chr12_125098168_+ | SINE | Alu | Name=AluJb |
| ADediting_327469 | chr12_125098175_+ | SINE | Alu | Name=AluJb |
| ADediting_327470 | chr12_125098251_+ | SINE | Alu | Name=AluJb |
| ADediting_327471 | chr12_125098252_+ | SINE | Alu | Name=AluJb |
| ADediting_327472 | chr12_125098272_+ | SINE | Alu | Name=AluJb |
| ADediting_327473 | chr12_125098283_+ | SINE | Alu | Name=AluJb |
| ADediting_327474 | chr12_125098521_+ | SINE | Alu | Name=AluSz |
| ADediting_327475 | chr12_125098532_+ | SINE | Alu | Name=AluSz |
| ADediting_327476 | chr12_125098545_+ | SINE | Alu | Name=AluSz |
| ADediting_327477 | chr12_125098632_+ | SINE | Alu | Name=AluSz |
| ADediting_327478 | chr12_125098649_+ | SINE | Alu | Name=AluSz |
| ADediting_327479 | chr12_125098725_+ | SINE | Alu | Name=AluSz |
| ADediting_327480 | chr12_125107783_+ | SINE | Alu | Name=AluSz6 |
| ADediting_327481 | chr12_125107784_+ | SINE | Alu | Name=AluSz6 |
| ADediting_327482 | chr12_125107842_+ | SINE | Alu | Name=AluSz6 |
| ADediting_327483 | chr12_125108768_+ | SINE | Alu | Name=AluSz6 |
| ADediting_327484 | chr12_125108797_+ | SINE | Alu | Name=AluSz6 |
| ADediting_327485 | chr12_125108925_+ | SINE | Alu | Name=AluSz6 |
| ADediting_327486 | chr12_125109163_+ | SINE | Alu | Name=AluJo |
| ADediting_327487 | chr12_125109232_+ | SINE | Alu | Name=AluJo |
| ADediting_327488 | chr12_125109257_+ | SINE | Alu | Name=AluJo |
| ADediting_327489 | chr12_125110094_+ | SINE | Alu | Name=AluSg |
| ADediting_327490 | chr12_125110120_+ | SINE | Alu | Name=AluSg |
| ADediting_327491 | chr12_125110270_+ | SINE | Alu | Name=AluSg |
| ADediting_327492 | chr12_125115360_+ | SINE | Alu | Name=AluSx3 |
| ADediting_327493 | chr12_125115402_+ | SINE | Alu | Name=AluSx3 |
| ADediting_327494 | chr12_125115534_+ | SINE | Alu | Name=AluSx3 |
| ADediting_327495 | chr12_125116544_+ | SINE | Alu | Name=AluY |
| ADediting_327496 | chr12_125116550_+ | SINE | Alu | Name=AluY |
| ADediting_327497 | chr12_125116557_+ | SINE | Alu | Name=AluY |
| ADediting_327498 | chr12_125116568_+ | SINE | Alu | Name=AluY |
| ADediting_327499 | chr12_125116603_+ | SINE | Alu | Name=AluY |
| ADediting_327500 | chr12_125116605_+ | SINE | Alu | Name=AluY |
| ADediting_327501 | chr12_125116629_+ | SINE | Alu | Name=AluY |
| ADediting_327502 | chr12_125116739_+ | SINE | Alu | Name=AluY |
| ADediting_327503 | chr12_125117068_+ | SINE | Alu | Name=AluJr |
| ADediting_327504 | chr12_125117156_+ | SINE | Alu | Name=AluSx1 |
| ADediting_327505 | chr12_125117183_+ | SINE | Alu | Name=AluSx1 |
| ADediting_327506 | chr12_125117202_+ | SINE | Alu | Name=AluSx1 |
| ADediting_327507 | chr12_125117263_+ | SINE | Alu | Name=AluSx1 |
| ADediting_327508 | chr12_125117287_+ | SINE | Alu | Name=AluSx1 |
| ADediting_327509 | chr12_125117293_+ | SINE | Alu | Name=AluSx1 |
| ADediting_327510 | chr12_125117294_+ | SINE | Alu | Name=AluSx1 |
| ADediting_327511 | chr12_125117321_+ | SINE | Alu | Name=AluSx1 |
| ADediting_327512 | chr12_125117708_+ | SINE | Alu | Name=AluJr |
| ADediting_327513 | chr12_125117715_+ | SINE | Alu | Name=AluJr |
| ADediting_327514 | chr12_125117730_+ | SINE | Alu | Name=AluJr |
| ADediting_327515 | chr12_125117731_+ | SINE | Alu | Name=AluJr |
| ADediting_327516 | chr12_125117757_+ | SINE | Alu | Name=AluJr |
| ADediting_327517 | chr12_125117785_+ | SINE | Alu | Name=AluJr |
| ADediting_327518 | chr12_125117837_+ | SINE | Alu | Name=AluJr |
| ADediting_327519 | chr12_125117869_+ | SINE | Alu | Name=AluJr |
| ADediting_327520 | chr12_125117873_+ | SINE | Alu | Name=AluJr |
| ADediting_327521 | chr12_125117890_+ | SINE | Alu | Name=AluJr |
| ADediting_327522 | chr12_125117904_+ | SINE | Alu | Name=AluJr |
| ADediting_327523 | chr12_125117909_+ | SINE | Alu | Name=AluJr |
| ADediting_327524 | chr12_125122386_+ | SINE | Alu | Name=AluSx3 |
| ADediting_327525 | chr12_125122416_+ | SINE | Alu | Name=AluSx3 |
| ADediting_327526 | chr12_125122522_+ | SINE | Alu | Name=AluSx3 |
| ADediting_327527 | chr12_125122523_+ | SINE | Alu | Name=AluSx3 |
| ADediting_327528 | chr12_125122549_+ | SINE | Alu | Name=AluSx3 |
| ADediting_327529 | chr12_125122558_+ | SINE | Alu | Name=AluSx3 |
| ADediting_327531 | chr12_125124081_+ | SINE | Alu | Name=AluJo |
| ADediting_327532 | chr12_125124111_+ | SINE | Alu | Name=AluJo |
| ADediting_327533 | chr12_125124125_+ | SINE | Alu | Name=AluJo |
| ADediting_327534 | chr12_125124130_+ | SINE | Alu | Name=AluJo |
| ADediting_327535 | chr12_125124133_+ | SINE | Alu | Name=AluJo |
| ADediting_327536 | chr12_125124166_+ | SINE | Alu | Name=AluJo |
| ADediting_327537 | chr12_125124174_+ | SINE | Alu | Name=AluJo |
| ADediting_327538 | chr12_125124205_+ | SINE | Alu | Name=AluJo |
| ADediting_327539 | chr12_125124210_+ | SINE | Alu | Name=AluJo |
| ADediting_327540 | chr12_125124220_+ | SINE | Alu | Name=AluJo |
| ADediting_327541 | chr12_125124252_+ | SINE | Alu | Name=AluJo |
| ADediting_327542 | chr12_125124281_+ | SINE | Alu | Name=AluJo |
| ADediting_327543 | chr12_125126601_+ | SINE | Alu | Name=AluJb |
| ADediting_327544 | chr12_125126603_+ | SINE | Alu | Name=AluJb |
| ADediting_327545 | chr12_125126646_+ | SINE | Alu | Name=AluJb |
| ADediting_327546 | chr12_125126649_+ | SINE | Alu | Name=AluJb |
| ADediting_327547 | chr12_125126656_+ | SINE | Alu | Name=AluJb |
| ADediting_327548 | chr12_125126661_+ | SINE | Alu | Name=AluJb |
| ADediting_327549 | chr12_125126681_+ | SINE | Alu | Name=AluJb |
| ADediting_327550 | chr12_125126682_+ | SINE | Alu | Name=AluJb |
| ADediting_327551 | chr12_125126686_+ | SINE | Alu | Name=AluJb |
| ADediting_327552 | chr12_125126694_+ | SINE | Alu | Name=AluJb |
| ADediting_327553 | chr12_125126711_+ | SINE | Alu | Name=AluJb |
| ADediting_327554 | chr12_125126715_+ | SINE | Alu | Name=AluJb |
| ADediting_327555 | chr12_125126721_+ | SINE | Alu | Name=AluJb |
| ADediting_327556 | chr12_125126817_+ | SINE | Alu | Name=AluJb |
| ADediting_327557 | chr12_125126818_+ | SINE | Alu | Name=AluJb |
| ADediting_327558 | chr12_125126830_+ | SINE | Alu | Name=AluJb |
| ADediting_327559 | chr12_125126857_+ | SINE | Alu | Name=AluJb |
| ADediting_327560 | chr12_125127019_+ | SINE | Alu | Name=AluSp |
| ADediting_327561 | chr12_125127020_+ | SINE | Alu | Name=AluSp |
| ADediting_327562 | chr12_125127032_+ | SINE | Alu | Name=AluSp |
| ADediting_327563 | chr12_125127036_+ | SINE | Alu | Name=AluSp |
| ADediting_327564 | chr12_125127046_+ | SINE | Alu | Name=AluSp |
| ADediting_327565 | chr12_125127055_+ | SINE | Alu | Name=AluSp |
| ADediting_327566 | chr12_125127060_+ | SINE | Alu | Name=AluSp |
| ADediting_327567 | chr12_125127061_+ | SINE | Alu | Name=AluSp |
| ADediting_327568 | chr12_125127075_+ | SINE | Alu | Name=AluSp |
| ADediting_327569 | chr12_125127131_+ | SINE | Alu | Name=AluSp |
| ADediting_327570 | chr12_125127467_+ | SINE | Alu | Name=AluSx |
| ADediting_327571 | chr12_125127468_+ | SINE | Alu | Name=AluSx |
| ADediting_327572 | chr12_125127503_+ | SINE | Alu | Name=AluSx |
| ADediting_327573 | chr12_125127505_+ | SINE | Alu | Name=AluSx |
| ADediting_327574 | chr12_125127516_+ | SINE | Alu | Name=AluSx |
| ADediting_327575 | chr12_125127571_+ | SINE | Alu | Name=AluSx |
| ADediting_327576 | chr12_125127581_+ | SINE | Alu | Name=AluSx |
| ADediting_327577 | chr12_125127627_+ | SINE | Alu | Name=AluSx |
| ADediting_327578 | chr12_125127641_+ | SINE | Alu | Name=AluSx |
| ADediting_327579 | chr12_125127683_+ | SINE | Alu | Name=AluSx |
| ADediting_327580 | chr12_125127706_+ | SINE | Alu | Name=AluSx |
| ADediting_327581 | chr12_125127712_+ | SINE | Alu | Name=AluSx |
| ADediting_327586 | chr12_125136212_+ | SINE | Alu | Name=AluJo |
| ADediting_327587 | chr12_125137225_+ | SINE | Alu | Name=AluSz |
| ADediting_327588 | chr12_125137248_+ | SINE | Alu | Name=AluSz |
| ADediting_327589 | chr12_125141423_+ | SINE | Alu | Name=AluY |
| ADediting_327590 | chr12_125141453_+ | SINE | Alu | Name=AluY |
| ADediting_327591 | chr12_125141470_+ | SINE | Alu | Name=AluY |
| ADediting_327592 | chr12_125141475_+ | SINE | Alu | Name=AluY |
| ADediting_327593 | chr12_125141483_+ | SINE | Alu | Name=AluY |
| ADediting_327594 | chr12_125141536_+ | SINE | Alu | Name=AluY |
| ADediting_327595 | chr12_125141540_+ | SINE | Alu | Name=AluY |
| ADediting_327596 | chr12_125141543_+ | SINE | Alu | Name=AluY |
| ADediting_327597 | chr12_125141546_+ | SINE | Alu | Name=AluY |
| ADediting_327598 | chr12_125141550_+ | SINE | Alu | Name=AluY |
| ADediting_327599 | chr12_125141574_+ | SINE | Alu | Name=AluY |
| ADediting_327600 | chr12_125141590_+ | SINE | Alu | Name=AluY |
| ADediting_327601 | chr12_125141618_+ | SINE | Alu | Name=AluY |
| ADediting_327602 | chr12_125141641_+ | SINE | Alu | Name=AluY |
| ADediting_327603 | chr12_125141642_+ | SINE | Alu | Name=AluY |
| ADediting_327604 | chr12_125141718_+ | SINE | Alu | Name=AluY |
| ADediting_327605 | chr12_125141720_+ | SINE | Alu | Name=AluY |
| ADediting_1531542 | chr12_125137348_+ | SINE | Alu | Name=AluSz |
| ADediting_1531543 | chr12_125141478_+ | SINE | Alu | Name=AluY |
| ADediting_1612522 | chr12_125083826_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1612523 | chr12_125083834_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1612524 | chr12_125084142_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1612525 | chr12_125084152_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1612526 | chr12_125098274_+ | SINE | Alu | Name=AluJb |
| ADediting_1612527 | chr12_125098299_+ | SINE | Alu | Name=AluJb |
| ADediting_1612528 | chr12_125098661_+ | SINE | Alu | Name=AluSz |
Top |
RNA A-to-I editing events in the alternative splicing sites for AACS |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
Top |
Differntial gene expression between RNA A-to-I edited versus non-edited samples for AACS |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
Top |
Protein coding region RNA A-to-I editings for AACS |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
Top |
The effects of the RNA editing to the miRNA binding sites for AACS |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1337757 | chr7_5495852_- | ENSG00000081760.17 | ENST00000316519.11 | AACS-201 | hsa-miR-589-3p | chr12 | 125142595 | 125142601 | 7mer-m8 | 125142578 | 125142602 | 151 | -16.72 |
| ADediting_1535951 | chr14_100874558_+ | ENSG00000081760.17 | ENST00000316519.11 | AACS-201 | hsa-miR-337-3p | chr12 | 125142866 | 125142872 | 7mer-m8 | 125142851 | 125142873 | 162 | -20.43 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1337757 | chr7_5495852_- | ENSG00000081760.17 | ENST00000316519.11 | AACS-201 | hsa-miR-589-3p | chr12 | 125142340 | 125142346 | 7mer-m8 | 125142324 | 125142347 | 144 | -16.28 |
| ADediting_1535953 | chr14_101045971_+ | ENSG00000081760.17 | ENST00000316519.11 | AACS-201 | hsa-miR-381-3p | chr12 | 125143162 | 125143168 | 7mer-m8 | 125143148 | 125143169 | 154 | -12.49 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000081760.17 | ENST00000316519.11 | AACS-201 | hsa-miR-381-3p | chr12 | 125143162 | 125143168 | 7mer-m8 | 125143148 | 125143169 | 154 | -12.49 |
| Differentially expressed gene-miRNA network |
Top |
The effects of the RNA editing to the stability of the RNA structures for AACS |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
Top |
Relation with ADAR for AACS |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | ADediting_327462 | chr12_125079418_+ | 0.35458967103403 | -0.0527540574725395 | 0.00443402750991192 | -0.161207030443748 | 3.62068211312579e-18 | 0.466635232148815 |
| DLPFC | ADediting_327463 | chr12_125079494_+ | 0.717155623325452 | -0.0206563980678796 | 0.066774580246834 | -0.104255364488099 | 3.28674445958807e-14 | 0.413150675201713 |
| TCX | ADediting_327534 | chr12_125124130_+ | 0.0365914648653284 | 0.170844067050761 | 7.13466178179704e-05 | 0.318471263883972 | 0.411208318310221 | -0.0675857876809725 |
| DLPFC | ADediting_327548 | chr12_125126661_+ | 3.89957385258363e-09 | 0.326545432247866 | 1.5157243214568e-10 | 0.353339028006186 | 0.00556142299987832 | 0.157127279049946 |
| DLPFC | ADediting_327549 | chr12_125126681_+ | 2.50933190613144e-07 | 0.287839002341136 | 2.86196961309563e-08 | 0.308715360717104 | 0.00815201389884853 | 0.150020838269873 |
| DLPFC | ADediting_327550 | chr12_125126682_+ | 3.44739813756784e-10 | 0.346796743534938 | 2.22084135327219e-11 | 0.36807075292013 | 0.0687023225439594 | 0.103530444653651 |
| DLPFC | ADediting_327552 | chr12_125126694_+ | 3.14047399425743e-10 | 0.347546763109629 | 7.73892489812968e-12 | 0.375848822780719 | 0.000254276512624813 | 0.206348878095345 |
| DLPFC | ADediting_327554 | chr12_125126715_+ | 3.1511617681173e-09 | 0.328384614737925 | 3.9101195983809e-10 | 0.345780520401205 | 3.41711628876235e-05 | 0.233040778535176 |
| DLPFC | ADediting_327555 | chr12_125126721_+ | 4.83674981458119e-08 | 0.303818828386253 | 1.28632845688144e-05 | 0.244972801984961 | 3.13077794076738e-05 | 0.234135077820796 |
| DLPFC | ADediting_327560 | chr12_125127019_+ | 2.5523208129947e-09 | 0.330191740651308 | 2.40874639652996e-12 | 0.384225271100201 | 0.0696406687038317 | 0.103183588449199 |
| DLPFC | ADediting_327561 | chr12_125127020_+ | 7.33138743684371e-09 | 0.321023538200574 | 1.37648597191658e-11 | 0.371625886230081 | 0.40912153882135 | 0.0470459606553194 |
| DLPFC | ADediting_327562 | chr12_125127032_+ | 6.96598298323983e-09 | 0.321474894928565 | 1.06790148690014e-08 | 0.317679926168196 | 0.000196415831858264 | 0.209971167274039 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 4.39779044101965e-44 | 0.683918476099146 | 4.68160727879254e-36 | 0.632590336345668 | 2.88363000183497e-19 | 0.479957177292824 |
| AC | 2.4090900470198e-69 | 0.844935842777117 | 1.34634255187521e-67 | 0.83934362149252 | 8.46875163503736e-07 | 0.305490473226682 |
| PCC | 4.84605753577149e-53 | 0.844062851026212 | 6.34350454144115e-75 | 0.911672831582581 | 0.23609951671859 | 0.0861345629367069 |
| CER | 3.61660201254508e-18 | 0.632976784745497 | 1.27694729297451e-16 | 0.609424601325755 | 0.0059979709578054 | 0.223390634388387 |
| TCX | 8.50759162860044e-26 | 0.72556970780912 | 6.80660871076861e-36 | 0.808473456667084 | 0.00813668970835319 | -0.215333575443203 |
| FP | 6.50350287126408e-41 | 0.800091458269301 | 5.21546945501919e-38 | 0.782197934924948 | 5.33930580680748e-05 | 0.298019315283219 |
| IFG | 8.26515327715683e-06 | 0.765458786213237 | 4.97960984062002e-06 | 0.776744145386603 | 0.274992008082411 | 0.227085660952327 |
| PG | 1.97340834171698e-16 | 0.555195019567545 | 2.02743409784255e-21 | 0.623445844790046 | 0.146765306997862 | -0.106811750179306 |
| STG | 3.31070477951547e-21 | 0.815895040271577 | 8.80706563047959e-23 | 0.832969372929022 | 0.609394840913191 | 0.056550549729076 |
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Relation with AD stages for AACS |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| CER | ADediting_327532 | chr12_125124111_+ | 0.00104769473749416 | 0.311122592114524 |
| CER | ADediting_327588 | chr12_125137248_+ | 0.000635655936410742 | 0.323573599705144 |
| IFG | ADediting_327581 | chr12_125127712_+ | 0.0354713369979928 | 0.422303326441651 |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 0.000204378642938989 | 0.350035210191479 |
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RelatedDrugs for AACS |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for AACS |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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