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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for SLC15A2 |
 Gene summary |
| Gene information | Gene symbol | SLC15A2 | Gene ID | 6565 |
| Gene name | solute carrier family 15 member 2 | |
| Synonyms | PEPT2 | |
| Cytomap | 3q13.33 | |
| Type of gene | protein-coding | |
| Description | solute carrier family 15 member 2kidney H(+)/peptide cotransporteroligopeptide transporter, kidney isoformpeptide transporter 2solute carrier family 15 (H+/peptide transporter), member 2solute carrier family 15 (oligopeptide transporter), member 2 | |
| Modification date | 20200313 | |
| UniProtAcc | Q16348, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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RNA A-to-I events for SLC15A2 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_1016368(121897997, +), ADediting_1016369(121898082, +), ADediting_1016370(121916938, +), ADediting_1016371(121916962, +), ADediting_1016372(121917072, +), ADediting_1016373(121917088, +), ADediting_1016374(121917346, +), ADediting_1016375(121917415, +), ADediting_1016376(121917417, +), ADediting_1016377(121917433, +), ADediting_1016378(121917434, +), ADediting_1016379(121917439, +), ADediting_1016380(121917456, +), ADediting_1016381(121917479, +), ADediting_1016382(121917482, +), ADediting_1016383(121917507, +), ADediting_1016384(121917541, +), ADediting_1016385(121917561, +), ADediting_1016386(121917565, +), ADediting_1016387(121917574, +), ADediting_1016388(121917584, +), ADediting_1016389(121917613, +), ADediting_1016390(121917637, +), ADediting_1016391(121917670, +), ADediting_1016392(121917675, +), ADediting_1016393(121920376, +), ADediting_1016394(121920564, +), ADediting_1016395(121942988, +), ADediting_1016396(121942992, +), ADediting_1016397(121942994, +), ADediting_1016398(121943010, +), ADediting_1016399(121943011, +), ADediting_1016400(121943016, +), ADediting_1016401(121943146, +), ADediting_1016402(121943155, +), ADediting_1016403(121943169, +), ADediting_1016404(121943172, +), ADediting_1016405(121943175, +), ADediting_1016406(121943198, +), ADediting_1643883(121917082, +), ADediting_1643884(121917094, +), ADediting_1643885(121917573, +), |
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RNA editing positional annotations for SLC15A2 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_1016368 | chr3_121897997_+ | intronic |
| ADediting_1016369 | chr3_121898082_+ | intronic |
| ADediting_1016370 | chr3_121916938_+ | intronic |
| ADediting_1016371 | chr3_121916962_+ | intronic |
| ADediting_1016372 | chr3_121917072_+ | intronic |
| ADediting_1016373 | chr3_121917088_+ | intronic |
| ADediting_1016374 | chr3_121917346_+ | intronic |
| ADediting_1016375 | chr3_121917415_+ | intronic |
| ADediting_1016376 | chr3_121917417_+ | intronic |
| ADediting_1016377 | chr3_121917433_+ | intronic |
| ADediting_1016378 | chr3_121917434_+ | intronic |
| ADediting_1016379 | chr3_121917439_+ | intronic |
| ADediting_1016380 | chr3_121917456_+ | intronic |
| ADediting_1016381 | chr3_121917479_+ | intronic |
| ADediting_1016382 | chr3_121917482_+ | intronic |
| ADediting_1016383 | chr3_121917507_+ | intronic |
| ADediting_1016384 | chr3_121917541_+ | intronic |
| ADediting_1016385 | chr3_121917561_+ | intronic |
| ADediting_1016386 | chr3_121917565_+ | intronic |
| ADediting_1016387 | chr3_121917574_+ | intronic |
| ADediting_1016388 | chr3_121917584_+ | intronic |
| ADediting_1016389 | chr3_121917613_+ | intronic |
| ADediting_1016390 | chr3_121917637_+ | intronic |
| ADediting_1016391 | chr3_121917670_+ | intronic |
| ADediting_1016392 | chr3_121917675_+ | intronic |
| ADediting_1016393 | chr3_121920376_+ | intronic |
| ADediting_1016394 | chr3_121920564_+ | intronic |
| ADediting_1016395 | chr3_121942988_+ | UTR3 |
| ADediting_1016396 | chr3_121942992_+ | UTR3 |
| ADediting_1016397 | chr3_121942994_+ | UTR3 |
| ADediting_1016398 | chr3_121943010_+ | UTR3 |
| ADediting_1016399 | chr3_121943011_+ | UTR3 |
| ADediting_1016400 | chr3_121943016_+ | UTR3 |
| ADediting_1016401 | chr3_121943146_+ | UTR3 |
| ADediting_1016402 | chr3_121943155_+ | UTR3 |
| ADediting_1016403 | chr3_121943169_+ | UTR3 |
| ADediting_1016404 | chr3_121943172_+ | UTR3 |
| ADediting_1016405 | chr3_121943175_+ | UTR3 |
| ADediting_1016406 | chr3_121943198_+ | UTR3 |
| ADediting_1643883 | chr3_121917082_+ | intronic |
| ADediting_1643884 | chr3_121917094_+ | intronic |
| ADediting_1643885 | chr3_121917573_+ | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_1016368 | chr3_121897997_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1016369 | chr3_121898082_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1016370 | chr3_121916938_+ | SINE | Alu | Name=AluY |
| ADediting_1016371 | chr3_121916962_+ | SINE | Alu | Name=AluY |
| ADediting_1016372 | chr3_121917072_+ | SINE | Alu | Name=AluY |
| ADediting_1016373 | chr3_121917088_+ | SINE | Alu | Name=AluY |
| ADediting_1016374 | chr3_121917346_+ | LINE | L2 | Name=L2c |
| ADediting_1016375 | chr3_121917415_+ | SINE | Alu | Name=AluJr |
| ADediting_1016376 | chr3_121917417_+ | SINE | Alu | Name=AluJr |
| ADediting_1016377 | chr3_121917433_+ | SINE | Alu | Name=AluJr |
| ADediting_1016378 | chr3_121917434_+ | SINE | Alu | Name=AluJr |
| ADediting_1016379 | chr3_121917439_+ | SINE | Alu | Name=AluJr |
| ADediting_1016380 | chr3_121917456_+ | SINE | Alu | Name=AluJr |
| ADediting_1016381 | chr3_121917479_+ | SINE | Alu | Name=AluJr |
| ADediting_1016382 | chr3_121917482_+ | SINE | Alu | Name=AluJr |
| ADediting_1016383 | chr3_121917507_+ | SINE | Alu | Name=AluJr |
| ADediting_1016384 | chr3_121917541_+ | SINE | Alu | Name=AluJr |
| ADediting_1016385 | chr3_121917561_+ | SINE | Alu | Name=AluJr |
| ADediting_1016386 | chr3_121917565_+ | SINE | Alu | Name=AluJr |
| ADediting_1016387 | chr3_121917574_+ | SINE | Alu | Name=AluJr |
| ADediting_1016388 | chr3_121917584_+ | SINE | Alu | Name=AluJr |
| ADediting_1016389 | chr3_121917613_+ | SINE | Alu | Name=AluJr |
| ADediting_1016390 | chr3_121917637_+ | SINE | Alu | Name=AluJr |
| ADediting_1016391 | chr3_121917670_+ | SINE | Alu | Name=AluJr |
| ADediting_1016392 | chr3_121917675_+ | SINE | Alu | Name=AluJr |
| ADediting_1016393 | chr3_121920376_+ | SINE | Alu | Name=AluSc |
| ADediting_1016394 | chr3_121920564_+ | SINE | Alu | Name=AluSc |
| ADediting_1016395 | chr3_121942988_+ | SINE | Alu | Name=AluSq10 |
| ADediting_1016396 | chr3_121942992_+ | SINE | Alu | Name=AluSq10 |
| ADediting_1016397 | chr3_121942994_+ | SINE | Alu | Name=AluSq10 |
| ADediting_1016398 | chr3_121943010_+ | SINE | Alu | Name=AluSq10 |
| ADediting_1016399 | chr3_121943011_+ | SINE | Alu | Name=AluSq10 |
| ADediting_1016400 | chr3_121943016_+ | SINE | Alu | Name=AluSq10 |
| ADediting_1016401 | chr3_121943146_+ | SINE | Alu | Name=AluSq10 |
| ADediting_1016402 | chr3_121943155_+ | SINE | Alu | Name=AluSq10 |
| ADediting_1016403 | chr3_121943169_+ | SINE | Alu | Name=AluSq10 |
| ADediting_1016404 | chr3_121943172_+ | SINE | Alu | Name=AluSq10 |
| ADediting_1016405 | chr3_121943175_+ | SINE | Alu | Name=AluSq10 |
| ADediting_1016406 | chr3_121943198_+ | SINE | Alu | Name=AluSq10 |
| ADediting_1643883 | chr3_121917082_+ | SINE | Alu | Name=AluY |
| ADediting_1643884 | chr3_121917094_+ | SINE | Alu | Name=AluY |
| ADediting_1643885 | chr3_121917573_+ | SINE | Alu | Name=AluJr |
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RNA A-to-I editing events in the alternative splicing sites for SLC15A2 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for SLC15A2 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for SLC15A2 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for SLC15A2 |
| RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. |
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| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1016395 | chr3_121942988_+ | ENSG00000163406.11 | ENST00000489711.6 | SLC15A2-205 | hsa-miR-6850-3p | chr3 | 121942982 | 121942988 | 7mer-m8 | 121942970 | 121942989 | 145 | -26.09 |
| ADediting_1016396 | chr3_121942992_+ | ENSG00000163406.11 | ENST00000489711.6 | SLC15A2-205 | hsa-miR-6720-3p | chr3 | 121942986 | 121942993 | 8mer-1a | 121942973 | 121942993 | 152 | -19.17 |
| ADediting_1016398 | chr3_121943010_+ | ENSG00000163406.11 | ENST00000489711.6 | SLC15A2-205 | hsa-miR-513a-5p | chr3 | 121943004 | 121943010 | 7mer-m8 | 121942994 | 121943011 | 152 | -17.32 |
| ADediting_1016398 | chr3_121943010_+ | ENSG00000163406.11 | ENST00000489711.6 | SLC15A2-205 | hsa-miR-638 | chr3 | 121943009 | 121943015 | 7mer-1a | 121942991 | 121943015 | 153 | -31.53 |
| ADediting_1016399 | chr3_121943011_+ | ENSG00000163406.11 | ENST00000489711.6 | SLC15A2-205 | hsa-miR-8052 | chr3 | 121943009 | 121943015 | 7mer-1a | 121942997 | 121943015 | 148 | -29.06 |
| ADediting_1016400 | chr3_121943016_+ | ENSG00000163406.11 | ENST00000489711.6 | SLC15A2-205 | hsa-miR-371a-3p | chr3 | 121943014 | 121943020 | 7mer-m8 | 121942999 | 121943021 | 144 | -15.05 |
| ADediting_1016401 | chr3_121943146_+ | ENSG00000163406.11 | ENST00000489711.6 | SLC15A2-205 | hsa-miR-8052 | chr3 | 121943144 | 121943150 | 7mer-1a | 121943130 | 121943150 | 141 | -21.77 |
| ADediting_1016402 | chr3_121943155_+ | ENSG00000163406.11 | ENST00000489711.6 | SLC15A2-205 | hsa-miR-1207-3p | chr3 | 121943148 | 121943154 | 7mer-m8 | 121943138 | 121943155 | 140 | -12.56 |
| ADediting_1016402 | chr3_121943155_+ | ENSG00000163406.11 | ENST00000489711.6 | SLC15A2-205 | hsa-miR-646 | chr3 | 121943150 | 121943156 | 7mer-m8 | 121943139 | 121943157 | 145 | -14.99 |
| ADediting_1016403 | chr3_121943169_+ | ENSG00000163406.11 | ENST00000489711.6 | SLC15A2-205 | hsa-miR-5001-3p | chr3 | 121943167 | 121943174 | 8mer-1a | 121943153 | 121943174 | 153 | -22.88 |
| ADediting_1016405 | chr3_121943175_+ | ENSG00000163406.11 | ENST00000489711.6 | SLC15A2-205 | hsa-miR-3059-5p | chr3 | 121943171 | 121943177 | 7mer-m8 | 121943152 | 121943178 | 148 | -23.3 |
| ADediting_1016405 | chr3_121943175_+ | ENSG00000163406.11 | ENST00000489711.6 | SLC15A2-205 | hsa-miR-6780a-3p | chr3 | 121943170 | 121943177 | 8mer-1a | 121943155 | 121943177 | 161 | -22.49 |
| ADediting_1016405 | chr3_121943175_+ | ENSG00000163406.11 | ENST00000489711.6 | SLC15A2-205 | hsa-miR-7111-3p | chr3 | 121943171 | 121943177 | 7mer-1a | 121943156 | 121943177 | 140 | -26.92 |
| ADediting_1016406 | chr3_121943198_+ | ENSG00000163406.11 | ENST00000489711.6 | SLC15A2-205 | hsa-miR-1281 | chr3 | 121943191 | 121943197 | 7mer-m8 | 121943182 | 121943198 | 141 | -16.88 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1016395 | chr3_121942988_+ | ENSG00000163406.11 | ENST00000489711.6 | SLC15A2-205 | hsa-miR-1271-3p | chr3 | 121942986 | 121942993 | 8mer-1a | 121942972 | 121942993 | 140 | -20.36 |
| ADediting_1016395 | chr3_121942988_+ | ENSG00000163406.11 | ENST00000489711.6 | SLC15A2-205 | hsa-miR-550a-3-5p | chr3 | 121942986 | 121942993 | 8mer-1a | 121942974 | 121942993 | 140 | -15.18 |
| ADediting_1016395 | chr3_121942988_+ | ENSG00000163406.11 | ENST00000489711.6 | SLC15A2-205 | hsa-miR-550a-5p | chr3 | 121942986 | 121942993 | 8mer-1a | 121942969 | 121942993 | 142 | -16.78 |
| ADediting_1016396 | chr3_121942992_+ | ENSG00000163406.11 | ENST00000489711.6 | SLC15A2-205 | hsa-miR-1271-3p | chr3 | 121942986 | 121942993 | 8mer-1a | 121942972 | 121942993 | 140 | -20.36 |
| ADediting_1016396 | chr3_121942992_+ | ENSG00000163406.11 | ENST00000489711.6 | SLC15A2-205 | hsa-miR-550a-3-5p | chr3 | 121942986 | 121942993 | 8mer-1a | 121942974 | 121942993 | 140 | -15.18 |
| ADediting_1016396 | chr3_121942992_+ | ENSG00000163406.11 | ENST00000489711.6 | SLC15A2-205 | hsa-miR-550a-5p | chr3 | 121942986 | 121942993 | 8mer-1a | 121942969 | 121942993 | 142 | -16.78 |
| ADediting_1016396 | chr3_121942992_+ | ENSG00000163406.11 | ENST00000489711.6 | SLC15A2-205 | hsa-miR-550b-2-5p | chr3 | 121942987 | 121942993 | 7mer-m8 | 121942971 | 121942994 | 147 | -18.47 |
| ADediting_1016396 | chr3_121942992_+ | ENSG00000163406.11 | ENST00000489711.6 | SLC15A2-205 | hsa-miR-6529-3p | chr3 | 121942988 | 121942994 | 7mer-m8 | 121942974 | 121942995 | 145 | -13.3 |
| ADediting_1016396 | chr3_121942992_+ | ENSG00000163406.11 | ENST00000489711.6 | SLC15A2-205 | hsa-miR-6889-3p | chr3 | 121942988 | 121942994 | 7mer-m8 | 121942976 | 121942995 | 140 | -13.75 |
| ADediting_1016397 | chr3_121942994_+ | ENSG00000163406.11 | ENST00000489711.6 | SLC15A2-205 | hsa-miR-4252 | chr3 | 121942992 | 121942998 | 7mer-m8 | 121942981 | 121942999 | 150 | -18.25 |
| ADediting_1016397 | chr3_121942994_+ | ENSG00000163406.11 | ENST00000489711.6 | SLC15A2-205 | hsa-miR-550b-2-5p | chr3 | 121942987 | 121942993 | 7mer-m8 | 121942971 | 121942994 | 147 | -18.47 |
| ADediting_1016397 | chr3_121942994_+ | ENSG00000163406.11 | ENST00000489711.6 | SLC15A2-205 | hsa-miR-6529-3p | chr3 | 121942988 | 121942994 | 7mer-m8 | 121942974 | 121942995 | 145 | -13.3 |
| ADediting_1016397 | chr3_121942994_+ | ENSG00000163406.11 | ENST00000489711.6 | SLC15A2-205 | hsa-miR-6889-3p | chr3 | 121942988 | 121942994 | 7mer-m8 | 121942976 | 121942995 | 140 | -13.75 |
| ADediting_1016398 | chr3_121943010_+ | ENSG00000163406.11 | ENST00000489711.6 | SLC15A2-205 | hsa-miR-10399-5p | chr3 | 121943005 | 121943011 | 7mer-m8 | 121942991 | 121943012 | 144 | -10.53 |
| ADediting_1016398 | chr3_121943010_+ | ENSG00000163406.11 | ENST00000489711.6 | SLC15A2-205 | hsa-miR-7151-3p | chr3 | 121943003 | 121943010 | 8mer-1a | 121942994 | 121943010 | 146 | -17.62 |
| ADediting_1016399 | chr3_121943011_+ | ENSG00000163406.11 | ENST00000489711.6 | SLC15A2-205 | hsa-miR-10399-5p | chr3 | 121943005 | 121943011 | 7mer-m8 | 121942991 | 121943012 | 144 | -10.53 |
| ADediting_1016399 | chr3_121943011_+ | ENSG00000163406.11 | ENST00000489711.6 | SLC15A2-205 | hsa-miR-5089-5p | chr3 | 121943009 | 121943015 | 7mer-m8 | 121942997 | 121943016 | 146 | -13.24 |
| ADediting_1016400 | chr3_121943016_+ | ENSG00000163406.11 | ENST00000489711.6 | SLC15A2-205 | hsa-miR-5089-5p | chr3 | 121943009 | 121943015 | 7mer-m8 | 121942997 | 121943016 | 146 | -13.24 |
| ADediting_1016400 | chr3_121943016_+ | ENSG00000163406.11 | ENST00000489711.6 | SLC15A2-205 | hsa-miR-512-3p | chr3 | 121943014 | 121943020 | 7mer-m8 | 121943000 | 121943021 | 149 | -15 |
| ADediting_1016400 | chr3_121943016_+ | ENSG00000163406.11 | ENST00000489711.6 | SLC15A2-205 | hsa-miR-6506-5p | chr3 | 121943010 | 121943016 | 7mer-m8 | 121942995 | 121943017 | 144 | -16.21 |
| ADediting_1016401 | chr3_121943146_+ | ENSG00000163406.11 | ENST00000489711.6 | SLC15A2-205 | hsa-miR-10399-5p | chr3 | 121943140 | 121943146 | 7mer-m8 | 121943123 | 121943147 | 148 | -15.36 |
| ADediting_1016401 | chr3_121943146_+ | ENSG00000163406.11 | ENST00000489711.6 | SLC15A2-205 | hsa-miR-5089-5p | chr3 | 121943144 | 121943150 | 7mer-m8 | 121943132 | 121943151 | 148 | -15.02 |
| ADediting_1016403 | chr3_121943169_+ | ENSG00000163406.11 | ENST00000489711.6 | SLC15A2-205 | hsa-miR-3977 | chr3 | 121943165 | 121943171 | 7mer-m8 | 121943150 | 121943172 | 144 | -10.35 |
| ADediting_1016404 | chr3_121943172_+ | ENSG00000163406.11 | ENST00000489711.6 | SLC15A2-205 | hsa-miR-3977 | chr3 | 121943165 | 121943171 | 7mer-m8 | 121943150 | 121943172 | 144 | -10.35 |
| ADediting_1016405 | chr3_121943175_+ | ENSG00000163406.11 | ENST00000489711.6 | SLC15A2-205 | hsa-miR-4659a-3p | chr3 | 121943171 | 121943177 | 7mer-m8 | 121943157 | 121943178 | 140 | -9.28 |
| ADediting_1016405 | chr3_121943175_+ | ENSG00000163406.11 | ENST00000489711.6 | SLC15A2-205 | hsa-miR-4659b-3p | chr3 | 121943171 | 121943177 | 7mer-m8 | 121943157 | 121943178 | 140 | -11.61 |
| ADediting_1016406 | chr3_121943198_+ | ENSG00000163406.11 | ENST00000489711.6 | SLC15A2-205 | hsa-miR-5001-3p | chr3 | 121943193 | 121943199 | 7mer-m8 | 121943176 | 121943200 | 153 | -21.28 |
| ADediting_1016406 | chr3_121943198_+ | ENSG00000163406.11 | ENST00000489711.6 | SLC15A2-205 | hsa-miR-6836-3p | chr3 | 121943191 | 121943197 | 7mer-m8 | 121943178 | 121943198 | 147 | -20.52 |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1337757 | chr7_5495852_- | ENSG00000163406.11 | ENST00000489711.6 | SLC15A2-205 | hsa-miR-589-3p | chr3 | 121943969 | 121943976 | 8mer-1a | 121943953 | 121943976 | 149 | -15.02 |
| ADediting_1471004 | chr9_63819627_+ | ENSG00000163406.11 | ENST00000489711.6 | SLC15A2-205 | hsa-miR-4477b | chr3 | 121943347 | 121943353 | 7mer-m8 | 121943332 | 121943354 | 148 | -14.04 |
| ADediting_496066 | chr15_66496985_- | ENSG00000163406.11 | ENST00000295605.6 | SLC15A2-201 | hsa-miR-4512 | chr3 | 121941174 | 121941181 | 8mer-1a | 121941160 | 121941181 | 140 | -15.51 |
| ADediting_496066 | chr15_66496985_- | ENSG00000163406.11 | ENST00000489711.6 | SLC15A2-205 | hsa-miR-4512 | chr3 | 121941174 | 121941181 | 8mer-1a | 121941160 | 121941181 | 140 | -15.51 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1337757 | chr7_5495852_- | ENSG00000163406.11 | ENST00000489711.6 | SLC15A2-205 | hsa-miR-589-3p | chr3 | 121941717 | 121941723 | 7mer-m8 | 121941702 | 121941724 | 146 | -13.36 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for SLC15A2 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000489711.6 | protein_coding |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_1016395 | ENST00000489711.6 | chr3_121942988_+ | 4247 | -1510.70 | -1511.40 | -1513.40 |
| ADediting_1016396 | ENST00000489711.6 | chr3_121942992_+ | 4251 | -1513.30 | -1511.40 | -1513.40 |
| ADediting_1016397 | ENST00000489711.6 | chr3_121942994_+ | 4253 | -1510.80 | -1511.40 | -1513.40 |
| ADediting_1016398 | ENST00000489711.6 | chr3_121943010_+ | 4269 | -1514.00 | -1511.40 | -1513.40 |
| ADediting_1016399 | ENST00000489711.6 | chr3_121943011_+ | 4270 | -1511.40 | -1511.40 | -1513.40 |
| ADediting_1016400 | ENST00000489711.6 | chr3_121943016_+ | 4275 | -1510.60 | -1511.40 | -1513.40 |
| ADediting_1016401 | ENST00000489711.6 | chr3_121943146_+ | 4405 | -1511.50 | -1511.40 | -1513.40 |
| ADediting_1016402 | ENST00000489711.6 | chr3_121943155_+ | 4414 | -1511.80 | -1511.40 | -1513.40 |
| ADediting_1016403 | ENST00000489711.6 | chr3_121943169_+ | 4428 | -1511.10 | -1511.40 | -1513.40 |
| ADediting_1016404 | ENST00000489711.6 | chr3_121943172_+ | 4431 | -1510.60 | -1511.40 | -1513.40 |
| ADediting_1016405 | ENST00000489711.6 | chr3_121943175_+ | 4434 | -1511.40 | -1511.40 | -1513.40 |
| ADediting_1016406 | ENST00000489711.6 | chr3_121943198_+ | 4457 | -1513.50 | -1511.40 | -1513.40 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for SLC15A2 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 1.70849306208197e-13 | 0.402378124166917 | 6.81520577497186e-06 | 0.252417314193322 | 0.00985736454772294 | 0.146380166245619 |
| AC | 3.19703059028105e-56 | 0.796959926343983 | 2.8311779105615e-30 | 0.640559867777747 | 1.40762190970283e-23 | 0.576877883538727 |
| PCC | 1.34915491803636e-10 | 0.443255221260845 | 7.85757342157503e-06 | 0.317066021116083 | 1.3967236805772e-08 | 0.396215132916019 |
| CER | 2.69870256011889e-12 | 0.53115918280461 | 1.44491781154002e-07 | 0.413512592009633 | 1.06279920354222e-09 | 0.472155133258063 |
| TCX | 5.27686664810122e-06 | 0.362120961161943 | 0.0441006109398861 | 0.164625568733648 | 0.0813666492205029 | 0.142764363435691 |
| FP | 2.13516495877745e-11 | 0.474835584400402 | 5.11816531357066e-08 | 0.394388839839495 | 2.77732814205761e-09 | 0.427026803902871 |
| IFG | 0.00290540104443431 | 0.570452261930125 | 2.75252066793834e-05 | 0.735958671134933 | 0.0409010769334676 | 0.411649031704143 |
| PG | 8.56984660045575e-37 | 0.763571573262589 | 8.11367004978856e-16 | 0.545580317348914 | 0.204368690184401 | 0.0934887547706751 |
| STG | 3.90591260467959e-05 | 0.432918869487871 | 0.00910309818331578 | 0.282971742760729 | 1.48347905746825e-05 | 0.453403410444895 |
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Relation with AD stages for SLC15A2 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 3.44337046859083e-07 | 0.467208061084033 |
| TCX | 3.98414941076962e-08 | 0.502727946674443 |
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RelatedDrugs for SLC15A2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| SLC15A2 | Q16348 | DB00493 | Cefotaxime | Solute carrier family 15 member 2 | small molecule | approved |
| SLC15A2 | Q16348 | DB00713 | Oxacillin | Solute carrier family 15 member 2 | small molecule | approved|investigational |
| SLC15A2 | Q16348 | DB00415 | Ampicillin | Solute carrier family 15 member 2 | small molecule | approved|vet_approved |
| SLC15A2 | Q16348 | DB01053 | Benzylpenicillin | Solute carrier family 15 member 2 | small molecule | approved|vet_approved |
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RelatedDiseases for SLC15A2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| SLC15A2 | C0025202 | melanoma | 1 | CTD_human |
| SLC15A2 | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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