|
||||||
|
 | |
| |
| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
| |
| |
| The effects of the RNA editing to the stability of the RNA structures |
| |
| |
| |
|
Gene summary for SLC1A3 |
 Gene summary |
| Gene information | Gene symbol | SLC1A3 | Gene ID | 6507 |
| Gene name | solute carrier family 1 member 3 | |
| Synonyms | EA6|EAAT1|GLAST|GLAST1 | |
| Cytomap | 5p13.2 | |
| Type of gene | protein-coding | |
| Description | excitatory amino acid transporter 1GLAST-1sodium-dependent glutamate/aspartate transporter 1solute carrier family 1 (glial high affinity glutamate transporter), member 3 | |
| Modification date | 20200320 | |
| UniProtAcc | P43003, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| SLC1A3 | GO:0015813 | L-glutamate transmembrane transport | 26690923 |
| SLC1A3 | GO:0051938 | L-glutamate import | 7521911 |
| SLC1A3 | GO:0070779 | D-aspartate import across plasma membrane | 7521911 |
| SLC1A3 | GO:0071805 | potassium ion transmembrane transport | 20477940 |
| SLC1A3 | GO:0098712 | L-glutamate import across plasma membrane | 26690923 |
| SLC1A3 | GO:0140009 | L-aspartate import across plasma membrane | 20477940 |
| SLC1A3 | GO:1902476 | chloride transmembrane transport | 20477940 |
Top |
RNA A-to-I events for SLC1A3 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
 |
| RNA editing frequencies across three data sets. |
 |
| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
 |
| RNA A-to-I editing events in AD. |
| ADediting_1200256(36619411, +), ADediting_1200257(36619458, +), ADediting_1200258(36619536, +), ADediting_1200259(36619555, +), ADediting_1200260(36620925, +), ADediting_1200261(36621153, +), ADediting_1200262(36634165, +), ADediting_1200263(36653943, +), ADediting_1200264(36653944, +), ADediting_1200265(36653973, +), ADediting_1200266(36653983, +), ADediting_1200267(36653985, +), ADediting_1200268(36654005, +), ADediting_1200269(36654066, +), ADediting_1200270(36661197, +), ADediting_1200271(36661202, +), ADediting_1200272(36661216, +), ADediting_1200273(36661220, +), ADediting_1200274(36661225, +), ADediting_1200275(36661226, +), ADediting_1200276(36661235, +), ADediting_1200277(36661236, +), ADediting_1200278(36661254, +), ADediting_1200279(36661256, +), ADediting_1200280(36661261, +), ADediting_1200281(36661265, +), ADediting_1200282(36661269, +), ADediting_1200283(36661270, +), ADediting_1200284(36661291, +), ADediting_1200285(36661292, +), ADediting_1200286(36661297, +), ADediting_1200287(36661356, +), ADediting_1200288(36662598, +), ADediting_1200289(36663274, +), ADediting_1200290(36663355, +), ADediting_1200291(36663463, +), ADediting_1200292(36664177, +), ADediting_1200293(36664190, +), ADediting_1200294(36664195, +), ADediting_1200295(36664198, +), ADediting_1200296(36664203, +), ADediting_1200297(36664208, +), ADediting_1200298(36664214, +), ADediting_1200299(36664227, +), ADediting_1200300(36664273, +), ADediting_1200301(36664295, +), ADediting_1200302(36664300, +), ADediting_1200303(36664307, +), ADediting_1200304(36664322, +), ADediting_1200305(36664330, +), ADediting_1200306(36664355, +), ADediting_1200307(36664368, +), ADediting_1200308(36664376, +), ADediting_1200309(36664393, +), ADediting_1200310(36664395, +), ADediting_1200311(36664407, +), ADediting_1200312(36665334, +), ADediting_1656740(36661285, +), |
Top |
RNA editing positional annotations for SLC1A3 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_1200256 | chr5_36619411_+ | intronic |
| ADediting_1200257 | chr5_36619458_+ | intronic |
| ADediting_1200258 | chr5_36619536_+ | intronic |
| ADediting_1200259 | chr5_36619555_+ | intronic |
| ADediting_1200260 | chr5_36620925_+ | intronic |
| ADediting_1200261 | chr5_36621153_+ | intronic |
| ADediting_1200262 | chr5_36634165_+ | intronic |
| ADediting_1200263 | chr5_36653943_+ | intronic |
| ADediting_1200264 | chr5_36653944_+ | intronic |
| ADediting_1200265 | chr5_36653973_+ | intronic |
| ADediting_1200266 | chr5_36653983_+ | intronic |
| ADediting_1200267 | chr5_36653985_+ | intronic |
| ADediting_1200268 | chr5_36654005_+ | intronic |
| ADediting_1200269 | chr5_36654066_+ | intronic |
| ADediting_1200270 | chr5_36661197_+ | intronic |
| ADediting_1200271 | chr5_36661202_+ | intronic |
| ADediting_1200272 | chr5_36661216_+ | intronic |
| ADediting_1200273 | chr5_36661220_+ | intronic |
| ADediting_1200274 | chr5_36661225_+ | intronic |
| ADediting_1200275 | chr5_36661226_+ | intronic |
| ADediting_1200276 | chr5_36661235_+ | intronic |
| ADediting_1200277 | chr5_36661236_+ | intronic |
| ADediting_1200278 | chr5_36661254_+ | intronic |
| ADediting_1200279 | chr5_36661256_+ | intronic |
| ADediting_1200280 | chr5_36661261_+ | intronic |
| ADediting_1200281 | chr5_36661265_+ | intronic |
| ADediting_1200282 | chr5_36661269_+ | intronic |
| ADediting_1200283 | chr5_36661270_+ | intronic |
| ADediting_1200284 | chr5_36661291_+ | intronic |
| ADediting_1200285 | chr5_36661292_+ | intronic |
| ADediting_1200286 | chr5_36661297_+ | intronic |
| ADediting_1200287 | chr5_36661356_+ | intronic |
| ADediting_1200288 | chr5_36662598_+ | intronic |
| ADediting_1200289 | chr5_36663274_+ | intronic |
| ADediting_1200290 | chr5_36663355_+ | intronic |
| ADediting_1200291 | chr5_36663463_+ | intronic |
| ADediting_1200292 | chr5_36664177_+ | intronic |
| ADediting_1200293 | chr5_36664190_+ | intronic |
| ADediting_1200294 | chr5_36664195_+ | intronic |
| ADediting_1200295 | chr5_36664198_+ | intronic |
| ADediting_1200296 | chr5_36664203_+ | intronic |
| ADediting_1200297 | chr5_36664208_+ | intronic |
| ADediting_1200298 | chr5_36664214_+ | intronic |
| ADediting_1200299 | chr5_36664227_+ | intronic |
| ADediting_1200300 | chr5_36664273_+ | intronic |
| ADediting_1200301 | chr5_36664295_+ | intronic |
| ADediting_1200302 | chr5_36664300_+ | intronic |
| ADediting_1200303 | chr5_36664307_+ | intronic |
| ADediting_1200304 | chr5_36664322_+ | intronic |
| ADediting_1200305 | chr5_36664330_+ | intronic |
| ADediting_1200306 | chr5_36664355_+ | intronic |
| ADediting_1200307 | chr5_36664368_+ | intronic |
| ADediting_1200308 | chr5_36664376_+ | intronic |
| ADediting_1200309 | chr5_36664393_+ | intronic |
| ADediting_1200310 | chr5_36664395_+ | intronic |
| ADediting_1200311 | chr5_36664407_+ | intronic |
| ADediting_1200312 | chr5_36665334_+ | intronic |
| ADediting_1656740 | chr5_36661285_+ | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_1200256 | chr5_36619411_+ | SINE | Alu | Name=AluJr4 |
| ADediting_1200257 | chr5_36619458_+ | SINE | Alu | Name=AluJr4 |
| ADediting_1200258 | chr5_36619536_+ | SINE | Alu | Name=AluJr4 |
| ADediting_1200259 | chr5_36619555_+ | SINE | Alu | Name=AluJr4 |
| ADediting_1200260 | chr5_36620925_+ | SINE | Alu | Name=AluSx |
| ADediting_1200261 | chr5_36621153_+ | SINE | Alu | Name=AluSx |
| ADediting_1200262 | chr5_36634165_+ | SINE | Alu | Name=AluSz |
| ADediting_1200263 | chr5_36653943_+ | SINE | Alu | Name=AluSg |
| ADediting_1200264 | chr5_36653944_+ | SINE | Alu | Name=AluSg |
| ADediting_1200265 | chr5_36653973_+ | SINE | Alu | Name=AluSg |
| ADediting_1200266 | chr5_36653983_+ | SINE | Alu | Name=AluSg |
| ADediting_1200267 | chr5_36653985_+ | SINE | Alu | Name=AluSg |
| ADediting_1200268 | chr5_36654005_+ | SINE | Alu | Name=AluSg |
| ADediting_1200269 | chr5_36654066_+ | SINE | Alu | Name=AluSg |
| ADediting_1200270 | chr5_36661197_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1200271 | chr5_36661202_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1200272 | chr5_36661216_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1200273 | chr5_36661220_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1200274 | chr5_36661225_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1200275 | chr5_36661226_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1200276 | chr5_36661235_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1200277 | chr5_36661236_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1200278 | chr5_36661254_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1200279 | chr5_36661256_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1200280 | chr5_36661261_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1200281 | chr5_36661265_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1200282 | chr5_36661269_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1200283 | chr5_36661270_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1200284 | chr5_36661291_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1200285 | chr5_36661292_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1200286 | chr5_36661297_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1200287 | chr5_36661356_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1200289 | chr5_36663274_+ | SINE | Alu | Name=AluSx |
| ADediting_1200290 | chr5_36663355_+ | SINE | Alu | Name=AluSx |
| ADediting_1200291 | chr5_36663463_+ | SINE | Alu | Name=AluSx |
| ADediting_1200292 | chr5_36664177_+ | SINE | Alu | Name=AluSq2 |
| ADediting_1200293 | chr5_36664190_+ | SINE | Alu | Name=AluSq2 |
| ADediting_1200294 | chr5_36664195_+ | SINE | Alu | Name=AluSq2 |
| ADediting_1200295 | chr5_36664198_+ | SINE | Alu | Name=AluSq2 |
| ADediting_1200296 | chr5_36664203_+ | SINE | Alu | Name=AluSq2 |
| ADediting_1200297 | chr5_36664208_+ | SINE | Alu | Name=AluSq2 |
| ADediting_1200298 | chr5_36664214_+ | SINE | Alu | Name=AluSq2 |
| ADediting_1200299 | chr5_36664227_+ | SINE | Alu | Name=AluSq2 |
| ADediting_1200300 | chr5_36664273_+ | SINE | Alu | Name=AluSq2 |
| ADediting_1200301 | chr5_36664295_+ | SINE | Alu | Name=AluSq2 |
| ADediting_1200302 | chr5_36664300_+ | SINE | Alu | Name=AluSq2 |
| ADediting_1200303 | chr5_36664307_+ | SINE | Alu | Name=AluSq2 |
| ADediting_1200304 | chr5_36664322_+ | SINE | Alu | Name=AluSq2 |
| ADediting_1200305 | chr5_36664330_+ | SINE | Alu | Name=AluSq2 |
| ADediting_1200306 | chr5_36664355_+ | SINE | Alu | Name=AluSq2 |
| ADediting_1200307 | chr5_36664368_+ | SINE | Alu | Name=AluSq2 |
| ADediting_1200308 | chr5_36664376_+ | SINE | Alu | Name=AluSq2 |
| ADediting_1200309 | chr5_36664393_+ | SINE | Alu | Name=AluSq2 |
| ADediting_1200310 | chr5_36664395_+ | SINE | Alu | Name=AluSq2 |
| ADediting_1200311 | chr5_36664407_+ | SINE | Alu | Name=AluSq2 |
| ADediting_1200312 | chr5_36665334_+ | LINE | L2 | Name=L2a |
| ADediting_1656740 | chr5_36661285_+ | SINE | Alu | Name=AluSx1 |
Top |
RNA A-to-I editing events in the alternative splicing sites for SLC1A3 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
Top |
Differntial gene expression between RNA A-to-I edited versus non-edited samples for SLC1A3 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
 | |
 | |
 | |
 | |
 | |
 | |
 | |
 | |
| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
 |
 |
 |
 |
 |
 |
| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
Top |
Protein coding region RNA A-to-I editings for SLC1A3 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
Top |
The effects of the RNA editing to the miRNA binding sites for SLC1A3 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000079215.14 | ENST00000265113.9 | SLC1A3-201 | hsa-miR-4477b | chr5 | 36687227 | 36687233 | 7mer-m8 | 36687213 | 36687234 | 140 | -9.69 |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000079215.14 | ENST00000381918.3 | SLC1A3-202 | hsa-miR-4477b | chr5 | 36687227 | 36687233 | 7mer-m8 | 36687213 | 36687234 | 140 | -9.69 |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000079215.14 | ENST00000612708.4 | SLC1A3-215 | hsa-miR-4477b | chr5 | 36687227 | 36687233 | 7mer-m8 | 36687213 | 36687234 | 140 | -9.69 |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000079215.14 | ENST00000613445.4 | SLC1A3-216 | hsa-miR-4477b | chr5 | 36687227 | 36687233 | 7mer-m8 | 36687213 | 36687234 | 140 | -9.69 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000079215.14 | ENST00000265113.9 | SLC1A3-201 | hsa-miR-641 | chr5 | 36687213 | 36687219 | 7mer-m8 | 36687195 | 36687220 | 141 | -16.82 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000079215.14 | ENST00000381918.3 | SLC1A3-202 | hsa-miR-641 | chr5 | 36687213 | 36687219 | 7mer-m8 | 36687195 | 36687220 | 141 | -16.82 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000079215.14 | ENST00000612708.4 | SLC1A3-215 | hsa-miR-641 | chr5 | 36687213 | 36687219 | 7mer-m8 | 36687195 | 36687220 | 141 | -16.82 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000079215.14 | ENST00000613445.4 | SLC1A3-216 | hsa-miR-641 | chr5 | 36687213 | 36687219 | 7mer-m8 | 36687195 | 36687220 | 141 | -16.82 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000079215.14 | ENST00000265113.9 | SLC1A3-201 | hsa-miR-4775 | chr5 | 36686622 | 36686629 | 8mer-1a | 36686605 | 36686629 | 145 | -12.73 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000079215.14 | ENST00000265113.9 | SLC1A3-201 | hsa-miR-4775 | chr5 | 36687459 | 36687465 | 7mer-m8 | 36687446 | 36687466 | 147 | -10.16 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000079215.14 | ENST00000381918.3 | SLC1A3-202 | hsa-miR-4775 | chr5 | 36686622 | 36686629 | 8mer-1a | 36686605 | 36686629 | 145 | -12.73 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000079215.14 | ENST00000381918.3 | SLC1A3-202 | hsa-miR-4775 | chr5 | 36687459 | 36687465 | 7mer-m8 | 36687446 | 36687466 | 147 | -10.16 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000079215.14 | ENST00000612708.4 | SLC1A3-215 | hsa-miR-4775 | chr5 | 36686622 | 36686629 | 8mer-1a | 36686605 | 36686629 | 145 | -12.73 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000079215.14 | ENST00000612708.4 | SLC1A3-215 | hsa-miR-4775 | chr5 | 36687459 | 36687465 | 7mer-m8 | 36687446 | 36687466 | 147 | -10.16 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000079215.14 | ENST00000613445.4 | SLC1A3-216 | hsa-miR-4775 | chr5 | 36686622 | 36686629 | 8mer-1a | 36686605 | 36686629 | 145 | -12.73 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000079215.14 | ENST00000613445.4 | SLC1A3-216 | hsa-miR-4775 | chr5 | 36687459 | 36687465 | 7mer-m8 | 36687446 | 36687466 | 147 | -10.16 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| Differentially expressed gene-miRNA network |
Top |
The effects of the RNA editing to the stability of the RNA structures for SLC1A3 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
Top |
Relation with ADAR for SLC1A3 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | ADediting_1200289 | chr5_36663274_+ | 0.832927466099852 | 0.012029230785961 | 0.0201403340749969 | -0.131934166743999 | 6.56662559092205e-08 | 0.300923576211513 |
| STG | ADediting_1200289 | chr5_36663274_+ | 0.436978894498568 | 0.0859415739425472 | 0.3894860655721 | -0.0951056483416363 | 0.00523238080900362 | 0.302047417068003 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 1.96997262585929e-09 | 0.332396243313566 | 0.00715647591915579 | 0.152473665842236 | 0.0329583504837252 | 0.121165874251821 |
| AC | 2.41475927899192e-36 | 0.687654835178595 | 2.06776412044659e-17 | 0.502636197980873 | 3.81228103177092e-26 | 0.603015223556239 |
| PCC | 4.58734944695907e-06 | 0.32470360962604 | 0.00302872508129905 | 0.213449218872182 | 2.31768533266094e-07 | 0.363714000775026 |
| CER | 6.2563243634865e-10 | 0.477866451623926 | 0.011118665315973 | 0.206788333298878 | 1.82874401228019e-07 | 0.410400344312732 |
| FP | 3.67531284568449e-07 | 0.3701247503703 | 0.0290519291749812 | 0.163654692618486 | 2.76218934164024e-07 | 0.373764383247557 |
| IFG | 0.000120435998180468 | 0.693669935622115 | 0.000373258544885732 | 0.655698062611656 | 0.00553721019495827 | 0.537996916446079 |
| PG | 4.05994560886246e-36 | 0.758919938276402 | 3.0899448832784e-12 | 0.482487762798579 | 0.205965401608907 | 0.0931612755589199 |
| STG | 5.91946669403004e-05 | 0.423700984781954 | 0.0238415772544081 | 0.246427517964628 | 0.00235152078240846 | 0.327588987866681 |
Top |
Relation with AD stages for SLC1A3 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| STG | ADediting_1200277 | chr5_36661236_+ | 0.00551854381515645 | -0.300266342751693 |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| TCX | 2.26915768769626e-07 | 0.477518527207469 |
Top |
RelatedDrugs for SLC1A3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| SLC1A3 | P43003 | DB00142 | Glutamic Acid | Excitatory amino acid transporter 1 {ECO:0000303|PubMed:16042756, ECO:0000303|PubMed:8647279} | small molecule | approved|nutraceutical |
Top |
RelatedDiseases for SLC1A3 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| SLC1A3 | C0036341 | Schizophrenia | 4 | PSYGENET |
| SLC1A3 | C0004352 | Autistic Disorder | 1 | CTD_human |
| SLC1A3 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| SLC1A3 | C0014544 | Epilepsy | 1 | CTD_human |
| SLC1A3 | C0086237 | Epilepsy, Cryptogenic | 1 | CTD_human |
| SLC1A3 | C0178417 | Anhedonia | 1 | PSYGENET |
| SLC1A3 | C0236018 | Aura | 1 | CTD_human |
| SLC1A3 | C0751111 | Awakening Epilepsy | 1 | CTD_human |
| SLC1A3 | C2675211 | EPISODIC ATAXIA, TYPE 6 (disorder) | 1 | CTD_human;ORPHANET;UNIPROT |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|