Home Download Statistics Landscape Help Contact

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited versus non-edited samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with AD stages
	Related drugs with this gene
	Related diseases with this gene

Gene summary for SIPA1

Gene summary

Gene information	Gene symbol	SIPA1
	Gene ID	6494
	Gene name	signal-induced proliferation-associated 1
	Synonyms	SPA1
	Cytomap	11q13.1
	Type of gene	protein-coding
	Description	signal-induced proliferation-associated protein 1GTPase-activating protein Spa-1p130 SPA-1signal-induced proliferation-associated gene 1sipa-1
	Modification date	20200313
	UniProtAcc	Q96FS4,
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

Top

RNA A-to-I events for SIPA1

RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).

RNA editing frequencies across three data sets.

The number of RNA A-to-I editing events in different types of transcripts (# event, percentage).

RNA A-to-I editing events in AD.

ADediting_268456(65647928, +), ADediting_268457(65647965, +), ADediting_268458(65647971, +), ADediting_268459(65647972, +), ADediting_268460(65647975, +), ADediting_268461(65647989, +), ADediting_268462(65648011, +), ADediting_268463(65648037, +), ADediting_268464(65648053, +), ADediting_268465(65648074, +), ADediting_268466(65648095, +), ADediting_268467(65648107, +), ADediting_268468(65648116, +), ADediting_268469(65648134, +), ADediting_268470(65648135, +), ADediting_268471(65648147, +), ADediting_268472(65648487, +), ADediting_268473(65648578, +), ADediting_268474(65648579, +), ADediting_268475(65648609, +), ADediting_268476(65648619, +), ADediting_268477(65648624, +), ADediting_268478(65648633, +), ADediting_268479(65648635, +), ADediting_268480(65648658, +), ADediting_268481(65648668, +), ADediting_268482(65648671, +), ADediting_268483(65648672, +), ADediting_268484(65648673, +), ADediting_268485(65648686, +), ADediting_268486(65648690, +), ADediting_268487(65648712, +), ADediting_268488(65648713, +), ADediting_268489(65648735, +), ADediting_268490(65648739, +), ADediting_268491(65648743, +), ADediting_268492(65648744, +), ADediting_268493(65648748, +), ADediting_268494(65648758, +), ADediting_268495(65648778, +), ADediting_268496(65648816, +), ADediting_1528099(65648819, +),

Top

RNA editing positional annotations for SIPA1 using Annovar

Protein coding RNA editing(s).

ADeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

ADeditome ID	Position	Variant type
ADediting_268456	chr11_65647928_+	intronic
ADediting_268457	chr11_65647965_+	intronic
ADediting_268458	chr11_65647971_+	intronic
ADediting_268459	chr11_65647972_+	intronic
ADediting_268460	chr11_65647975_+	intronic
ADediting_268461	chr11_65647989_+	intronic
ADediting_268462	chr11_65648011_+	intronic
ADediting_268463	chr11_65648037_+	intronic
ADediting_268464	chr11_65648053_+	intronic
ADediting_268465	chr11_65648074_+	intronic
ADediting_268466	chr11_65648095_+	intronic
ADediting_268467	chr11_65648107_+	intronic
ADediting_268468	chr11_65648116_+	intronic
ADediting_268469	chr11_65648134_+	intronic
ADediting_268470	chr11_65648135_+	intronic
ADediting_268471	chr11_65648147_+	intronic
ADediting_268472	chr11_65648487_+	intronic
ADediting_268473	chr11_65648578_+	intronic
ADediting_268474	chr11_65648579_+	intronic
ADediting_268475	chr11_65648609_+	intronic
ADediting_268476	chr11_65648619_+	intronic
ADediting_268477	chr11_65648624_+	intronic
ADediting_268478	chr11_65648633_+	intronic
ADediting_268479	chr11_65648635_+	intronic
ADediting_268480	chr11_65648658_+	intronic
ADediting_268481	chr11_65648668_+	intronic
ADediting_268482	chr11_65648671_+	intronic
ADediting_268483	chr11_65648672_+	intronic
ADediting_268484	chr11_65648673_+	intronic
ADediting_268485	chr11_65648686_+	intronic
ADediting_268486	chr11_65648690_+	intronic
ADediting_268487	chr11_65648712_+	intronic
ADediting_268488	chr11_65648713_+	intronic
ADediting_268489	chr11_65648735_+	intronic
ADediting_268490	chr11_65648739_+	intronic
ADediting_268491	chr11_65648743_+	intronic
ADediting_268492	chr11_65648744_+	intronic
ADediting_268493	chr11_65648748_+	intronic
ADediting_268494	chr11_65648758_+	intronic
ADediting_268495	chr11_65648778_+	intronic
ADediting_268496	chr11_65648816_+	intronic
ADediting_1528099	chr11_65648819_+	intronic

Repat-regional RNA editing(s).

ADeditome ID	Position	Repeat family	Repeat sub family	Repeat name
ADediting_268456	chr11_65647928_+	SINE	Alu	Name=AluSq2
ADediting_268457	chr11_65647965_+	SINE	Alu	Name=AluSq2
ADediting_268458	chr11_65647971_+	SINE	Alu	Name=AluSq2
ADediting_268459	chr11_65647972_+	SINE	Alu	Name=AluSq2
ADediting_268460	chr11_65647975_+	SINE	Alu	Name=AluSq2
ADediting_268461	chr11_65647989_+	SINE	Alu	Name=AluSq2
ADediting_268462	chr11_65648011_+	SINE	Alu	Name=AluSq2
ADediting_268463	chr11_65648037_+	SINE	Alu	Name=AluSq2
ADediting_268464	chr11_65648053_+	SINE	Alu	Name=AluSq2
ADediting_268465	chr11_65648074_+	SINE	Alu	Name=AluSq2
ADediting_268466	chr11_65648095_+	SINE	Alu	Name=AluSq2
ADediting_268467	chr11_65648107_+	SINE	Alu	Name=AluSq2
ADediting_268468	chr11_65648116_+	SINE	Alu	Name=AluSq2
ADediting_268469	chr11_65648134_+	SINE	Alu	Name=AluSq2
ADediting_268470	chr11_65648135_+	SINE	Alu	Name=AluSq2
ADediting_268471	chr11_65648147_+	SINE	Alu	Name=AluSq2
ADediting_268472	chr11_65648487_+	DNA	hAT-Charlie	Name=MER58B
ADediting_268473	chr11_65648578_+	SINE	Alu	Name=AluSq2
ADediting_268474	chr11_65648579_+	SINE	Alu	Name=AluSq2
ADediting_268475	chr11_65648609_+	SINE	Alu	Name=AluSq2
ADediting_268476	chr11_65648619_+	SINE	Alu	Name=AluSq2
ADediting_268477	chr11_65648624_+	SINE	Alu	Name=AluSq2
ADediting_268478	chr11_65648633_+	SINE	Alu	Name=AluSq2
ADediting_268479	chr11_65648635_+	SINE	Alu	Name=AluSq2
ADediting_268480	chr11_65648658_+	SINE	Alu	Name=AluSq2
ADediting_268481	chr11_65648668_+	SINE	Alu	Name=AluSq2
ADediting_268482	chr11_65648671_+	SINE	Alu	Name=AluSq2
ADediting_268483	chr11_65648672_+	SINE	Alu	Name=AluSq2
ADediting_268484	chr11_65648673_+	SINE	Alu	Name=AluSq2
ADediting_268485	chr11_65648686_+	SINE	Alu	Name=AluSq2
ADediting_268486	chr11_65648690_+	SINE	Alu	Name=AluSq2
ADediting_268487	chr11_65648712_+	SINE	Alu	Name=AluSq2
ADediting_268488	chr11_65648713_+	SINE	Alu	Name=AluSq2
ADediting_268489	chr11_65648735_+	SINE	Alu	Name=AluSq2
ADediting_268490	chr11_65648739_+	SINE	Alu	Name=AluSq2
ADediting_268491	chr11_65648743_+	SINE	Alu	Name=AluSq2
ADediting_268492	chr11_65648744_+	SINE	Alu	Name=AluSq2
ADediting_268493	chr11_65648748_+	SINE	Alu	Name=AluSq2
ADediting_268494	chr11_65648758_+	SINE	Alu	Name=AluSq2
ADediting_268495	chr11_65648778_+	SINE	Alu	Name=AluSq2
ADediting_268496	chr11_65648816_+	SINE	Alu	Name=AluSq2
ADediting_1528099	chr11_65648819_+	SINE	Alu	Name=AluSq2

Top

RNA A-to-I editing events in the alternative splicing sites for SIPA1

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

ADeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

Top

Differntial gene expression between RNA A-to-I edited versus non-edited samples for SIPA1

Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A.

Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window.

- Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window.

ADeditome ID

Chr

Positoing

Skipped exon

ENSG

ENSTs

Top

Protein coding region RNA A-to-I editings for SIPA1

- Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window.

Top

The effects of the RNA editing to the miRNA binding sites for SIPA1

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

Top

The effects of the RNA editing to the stability of the RNA structures for SIPA1

- RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in miRNA.

ADeditom_ID

ENST

mir_ID

Editing_Information

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

RNA A-to-I editing in mRNA.

ADeditom_ID

ENST

Editing_Information

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

RNA A-to-I editing in lncRNA.

ADeditom_ID

ENST

Editing_Information

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

Top

Relation with ADAR for SIPA1

Correlation between ADAR gene expression and RNA editing frequency

Tissue	ADeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
DLPFC	ADediting_268457	chr11_65647965_+	0.267307544021885	0.0631954168255485	0.411759101203555	-0.0467818745831329	4.93954228874191e-15	0.425077216706798
DLPFC	ADediting_268459	chr11_65647972_+	0.559388542418147	0.0332800280921846	0.232313513276253	-0.0680347421856436	1.60937251484305e-13	0.402775597424505
DLPFC	ADediting_268460	chr11_65647975_+	0.985687799344953	-0.0010229789232415	0.109017110920175	-0.0912017197427953	4.57342687558279e-11	0.362617923956156
DLPFC	ADediting_268461	chr11_65647989_+	0.833817787553854	0.0119641807165939	0.367164920487078	-0.0513923640668738	2.67821017953972e-08	0.309328273346503
DLPFC	ADediting_268462	chr11_65648011_+	0.27387600434331	0.0623366211012437	0.39429664610267	-0.0485494923491016	1.34159363174629e-17	0.459503657478421

Correlation between ADAR gene expression and this gene's expression

Tissue	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
DLPFC	0.485150183908825	-0.0397912313243949	0.86450188605255	-0.00973114079876025	1.14415509469737e-14	0.419849428425303
AC	5.99996229904776e-15	0.467035228871563	5.66583777422105e-09	0.357998554217338	6.85699754120926e-24	0.580186967245837
CER	0.0173148016626886	-0.194094393922827	0.72217047275661	-0.0292699468709841	5.09329900322266e-05	0.324505211802552
TCX	0.0366841742055684	-0.170760996359076	1.39582608835331e-08	-0.442798654359908	4.09697350263682e-11	0.505691298137147
FP	0.703657846253287	-0.0287076181122373	0.0990286914842986	-0.124037250168151	3.16914538380767e-08	0.400004109703161
IFG	0.377832422192077	0.184296986135021	0.115621655011422	0.322718752070788	0.0170579877753743	0.47256691571855
PG	0.075603051488897	-0.130602293000429	0.000264719373339052	-0.264458895756695	9.81635245322948e-11	0.4516094820833
STG	0.609582460993486	-0.0565209443552072	0.00107210033415613	-0.350729813694016	2.18704818121466e-09	0.596168186181049

Top

Relation with AD stages for SIPA1

Correlation between AD stages and RNA editing frequency

Tissue

ADeditomID

position

P-val

Coeff.

Correlation between AD stages and this gene's expression

Tissue	P-val	Coeff.
PCC	1.87783456203263e-05	0.304239079217726
PG	3.05899115405502e-08	0.392314756915074

Top

RelatedDrugs for SIPA1

Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

RelatedDiseases for SIPA1

Diseases associated with this gene. (DisGeNet 4.0)

Gene	Disease ID	Disease name	# pubmeds	Source
SIPA1	C0025202	melanoma	1	CTD_human

Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth) Web File Viewing | Emergency Information |Site Policies