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Center for Computational Systems Medicine
Soverview

Gene summary

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RNA A-to-I events

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Differntial gene expression between RNA A-to-I edited versus non-edited samples

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Protein coding region RNA A-to-I editings

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The effects of the RNA editing to the miRNA binding sites

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The effects of the RNA editing to the stability of the RNA structures

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Relation with ADAR

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Relation with AD stages

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Related drugs with this gene

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Related diseases with this gene


Gene summary for ETNPPL

check button Gene summary
Gene informationGene symbol

ETNPPL

Gene ID

64850

Gene nameethanolamine-phosphate phospho-lyase
SynonymsAGXT2L1
Cytomap

4q25

Type of geneprotein-coding
Descriptionethanolamine-phosphate phospho-lyasealanine--glyoxylate aminotransferase 2-like 1
Modification date20200313
UniProtAcc

Q8TBG4,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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RNA A-to-I events for ETNPPL

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
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check button RNA A-to-I editing events in AD.
ADediting_1102155(108744076, -), ADediting_1102156(108744078, -), ADediting_1102157(108744094, -), ADediting_1102158(108744121, -), ADediting_1102159(108744133, -), ADediting_1102160(108744139, -), ADediting_1102161(108744149, -), ADediting_1102162(108744161, -), ADediting_1102163(108744178, -), ADediting_1102164(108744247, -), ADediting_1102165(108744751, -), ADediting_1102166(108744775, -), ADediting_1102167(108744804, -), ADediting_1102168(108744820, -), ADediting_1102169(108744846, -), ADediting_1102170(108744849, -), ADediting_1102171(108744856, -), ADediting_1102172(108744876, -), ADediting_1102173(108744884, -), ADediting_1102174(108744893, -), ADediting_1102175(108744907, -), ADediting_1102176(108744926, -), ADediting_1102177(108744952, -), ADediting_1102178(108750439, -), ADediting_1102179(108753497, -), ADediting_1102180(108753507, -), ADediting_1102181(108753555, -), ADediting_1102182(108753562, -), ADediting_1102183(108753618, -), ADediting_1102184(108753620, -), ADediting_1102185(108753648, -), ADediting_1102186(108754097, -), ADediting_1102187(108754102, -), ADediting_1102188(108754106, -), ADediting_1102189(108754112, -), ADediting_1102190(108754122, -), ADediting_1102191(108754138, -), ADediting_1102192(108754191, -), ADediting_1102193(108754197, -), ADediting_1102194(108754201, -), ADediting_1102195(108754251, -), ADediting_1102196(108756717, -), ADediting_1102197(108756788, -), ADediting_1102198(108757521, -), ADediting_1102199(108757522, -), ADediting_1102200(108757600, -), ADediting_1102201(108757682, -), ADediting_1102202(108757688, -), ADediting_1102203(108758072, -), ADediting_1102204(108758073, -), ADediting_1102205(108758081, -), ADediting_1102206(108758120, -), ADediting_1102207(108758124, -), ADediting_1102208(108758130, -), ADediting_1102209(108758156, -), ADediting_1102210(108758195, -), ADediting_1102211(108758210, -), ADediting_1102212(108758211, -), ADediting_1102213(108758218, -), ADediting_1102214(108758219, -), ADediting_1102215(108758254, -), ADediting_1102216(108758262, -), ADediting_1102217(108758263, -), ADediting_1102218(108758848, -), ADediting_1102219(108758885, -), ADediting_1102220(108758924, -), ADediting_1102221(108758927, -), ADediting_1102222(108758937, -), ADediting_1102223(108759010, -), ADediting_1102224(108759279, -), ADediting_1102225(108759349, -), ADediting_1102226(108759363, -), ADediting_1576088(108753483, -), ADediting_1576089(108753522, -),

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RNA editing positional annotations for ETNPPL using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_1102155chr4_108744076_-intronic
ADediting_1102156chr4_108744078_-intronic
ADediting_1102157chr4_108744094_-intronic
ADediting_1102158chr4_108744121_-intronic
ADediting_1102159chr4_108744133_-intronic
ADediting_1102160chr4_108744139_-intronic
ADediting_1102161chr4_108744149_-intronic
ADediting_1102162chr4_108744161_-intronic
ADediting_1102163chr4_108744178_-intronic
ADediting_1102164chr4_108744247_-intronic
ADediting_1102165chr4_108744751_-intronic
ADediting_1102166chr4_108744775_-intronic
ADediting_1102167chr4_108744804_-intronic
ADediting_1102168chr4_108744820_-intronic
ADediting_1102169chr4_108744846_-intronic
ADediting_1102170chr4_108744849_-intronic
ADediting_1102171chr4_108744856_-intronic
ADediting_1102172chr4_108744876_-intronic
ADediting_1102173chr4_108744884_-intronic
ADediting_1102174chr4_108744893_-intronic
ADediting_1102175chr4_108744907_-intronic
ADediting_1102176chr4_108744926_-intronic
ADediting_1102177chr4_108744952_-intronic
ADediting_1102178chr4_108750439_-intronic
ADediting_1102179chr4_108753497_-intronic
ADediting_1102180chr4_108753507_-intronic
ADediting_1102181chr4_108753555_-intronic
ADediting_1102182chr4_108753562_-intronic
ADediting_1102183chr4_108753618_-intronic
ADediting_1102184chr4_108753620_-intronic
ADediting_1102185chr4_108753648_-intronic
ADediting_1102186chr4_108754097_-intronic
ADediting_1102187chr4_108754102_-intronic
ADediting_1102188chr4_108754106_-intronic
ADediting_1102189chr4_108754112_-intronic
ADediting_1102190chr4_108754122_-intronic
ADediting_1102191chr4_108754138_-intronic
ADediting_1102192chr4_108754191_-intronic
ADediting_1102193chr4_108754197_-intronic
ADediting_1102194chr4_108754201_-intronic
ADediting_1102195chr4_108754251_-intronic
ADediting_1102196chr4_108756717_-intronic
ADediting_1102197chr4_108756788_-intronic
ADediting_1102198chr4_108757521_-intronic
ADediting_1102199chr4_108757522_-intronic
ADediting_1102200chr4_108757600_-intronic
ADediting_1102201chr4_108757682_-intronic
ADediting_1102202chr4_108757688_-intronic
ADediting_1102203chr4_108758072_-intronic
ADediting_1102204chr4_108758073_-intronic
ADediting_1102205chr4_108758081_-intronic
ADediting_1102206chr4_108758120_-intronic
ADediting_1102207chr4_108758124_-intronic
ADediting_1102208chr4_108758130_-intronic
ADediting_1102209chr4_108758156_-intronic
ADediting_1102210chr4_108758195_-intronic
ADediting_1102211chr4_108758210_-intronic
ADediting_1102212chr4_108758211_-intronic
ADediting_1102213chr4_108758218_-intronic
ADediting_1102214chr4_108758219_-intronic
ADediting_1102215chr4_108758254_-intronic
ADediting_1102216chr4_108758262_-intronic
ADediting_1102217chr4_108758263_-intronic
ADediting_1102218chr4_108758848_-intronic
ADediting_1102219chr4_108758885_-intronic
ADediting_1102220chr4_108758924_-intronic
ADediting_1102221chr4_108758927_-intronic
ADediting_1102222chr4_108758937_-intronic
ADediting_1102223chr4_108759010_-intronic
ADediting_1102224chr4_108759279_-intronic
ADediting_1102225chr4_108759349_-intronic
ADediting_1102226chr4_108759363_-intronic
ADediting_1576088chr4_108753483_-intronic
ADediting_1576089chr4_108753522_-intronic

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_1102155chr4_108744076_-SINEAluName=AluSx4
ADediting_1102156chr4_108744078_-SINEAluName=AluSx4
ADediting_1102157chr4_108744094_-SINEAluName=AluSx4
ADediting_1102158chr4_108744121_-SINEAluName=AluSx4
ADediting_1102159chr4_108744133_-SINEAluName=AluSx4
ADediting_1102160chr4_108744139_-SINEAluName=AluSx4
ADediting_1102161chr4_108744149_-SINEAluName=AluSx4
ADediting_1102162chr4_108744161_-SINEAluName=AluSx4
ADediting_1102163chr4_108744178_-SINEAluName=AluSx4
ADediting_1102164chr4_108744247_-SINEAluName=AluSx4
ADediting_1102165chr4_108744751_-SINEAluName=AluJb
ADediting_1102166chr4_108744775_-SINEAluName=AluJb
ADediting_1102167chr4_108744804_-SINEAluName=AluJb
ADediting_1102168chr4_108744820_-SINEAluName=AluJb
ADediting_1102169chr4_108744846_-SINEAluName=AluJb
ADediting_1102170chr4_108744849_-SINEAluName=AluJb
ADediting_1102171chr4_108744856_-SINEAluName=AluJb
ADediting_1102172chr4_108744876_-SINEAluName=AluJb
ADediting_1102173chr4_108744884_-SINEAluName=AluJb
ADediting_1102174chr4_108744893_-SINEAluName=AluJb
ADediting_1102175chr4_108744907_-SINEAluName=AluJb
ADediting_1102176chr4_108744926_-SINEAluName=AluJb
ADediting_1102177chr4_108744952_-SINEAluName=AluJb
ADediting_1102178chr4_108750439_-LTRERVLName=MLT2A1
ADediting_1102179chr4_108753497_-SINEAluName=AluSz
ADediting_1102180chr4_108753507_-SINEAluName=AluSz
ADediting_1102181chr4_108753555_-SINEAluName=AluSz
ADediting_1102182chr4_108753562_-SINEAluName=AluSz
ADediting_1102183chr4_108753618_-SINEAluName=AluSz
ADediting_1102184chr4_108753620_-SINEAluName=AluSz
ADediting_1102185chr4_108753648_-SINEAluName=AluSz
ADediting_1102186chr4_108754097_-SINEAluName=AluSx1
ADediting_1102187chr4_108754102_-SINEAluName=AluSx1
ADediting_1102188chr4_108754106_-SINEAluName=AluSx1
ADediting_1102189chr4_108754112_-SINEAluName=AluSx1
ADediting_1102190chr4_108754122_-SINEAluName=AluSx1
ADediting_1102191chr4_108754138_-SINEAluName=AluSx1
ADediting_1102192chr4_108754191_-SINEAluName=AluSx1
ADediting_1102193chr4_108754197_-SINEAluName=AluSx1
ADediting_1102194chr4_108754201_-SINEAluName=AluSx1
ADediting_1102195chr4_108754251_-SINEAluName=AluSx1
ADediting_1102196chr4_108756717_-SINEAluName=AluSx3
ADediting_1102197chr4_108756788_-SINEAluName=AluSx3
ADediting_1102198chr4_108757521_-SINEAluName=FLAM_C
ADediting_1102199chr4_108757522_-SINEAluName=FLAM_C
ADediting_1102200chr4_108757600_-SINEAluName=FLAM_C
ADediting_1102201chr4_108757682_-SINEAluName=AluJb
ADediting_1102202chr4_108757688_-SINEAluName=AluJb
ADediting_1102203chr4_108758072_-SINEAluName=AluSc5
ADediting_1102204chr4_108758073_-SINEAluName=AluSc5
ADediting_1102205chr4_108758081_-SINEAluName=AluSc5
ADediting_1102206chr4_108758120_-SINEAluName=AluSc5
ADediting_1102207chr4_108758124_-SINEAluName=AluSc5
ADediting_1102208chr4_108758130_-SINEAluName=AluSc5
ADediting_1102209chr4_108758156_-SINEAluName=AluSc5
ADediting_1102210chr4_108758195_-SINEAluName=AluSc5
ADediting_1102211chr4_108758210_-SINEAluName=AluSc5
ADediting_1102212chr4_108758211_-SINEAluName=AluSc5
ADediting_1102213chr4_108758218_-SINEAluName=AluSc5
ADediting_1102214chr4_108758219_-SINEAluName=AluSc5
ADediting_1102215chr4_108758254_-SINEAluName=AluSc5
ADediting_1102216chr4_108758262_-SINEAluName=AluSc5
ADediting_1102217chr4_108758263_-SINEAluName=AluSc5
ADediting_1102218chr4_108758848_-SINEAluName=AluSp
ADediting_1102219chr4_108758885_-SINEAluName=AluSp
ADediting_1102220chr4_108758924_-SINEAluName=AluSp
ADediting_1102221chr4_108758927_-SINEAluName=AluSp
ADediting_1102222chr4_108758937_-SINEAluName=AluSp
ADediting_1102223chr4_108759010_-SINEAluName=AluSp
ADediting_1102224chr4_108759279_-SINEAluName=AluYc
ADediting_1102225chr4_108759349_-SINEAluName=AluYc
ADediting_1102226chr4_108759363_-SINEAluName=AluYc
ADediting_1576088chr4_108753483_-SINEAluName=AluSz
ADediting_1576089chr4_108753522_-SINEAluName=AluSz

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RNA A-to-I editing events in the alternative splicing sites for ETNPPL

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for ETNPPL

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
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check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
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check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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ADeditome IDChrPositoingSkipped exonENSGENSTs

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Protein coding region RNA A-to-I editings for ETNPPL

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for ETNPPL


check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for ETNPPL

check button - RNA A-to-I editing in mRNA.
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ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in miRNA.
ADeditom_IDENSTmir_IDEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in mRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in lncRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for ETNPPL

check button Correlation between ADAR gene expression and RNA editing frequency
TissueADeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFCADediting_1102155chr4_108744076_-0.1229302399452960.08779865005328970.5432148055230280.03465937830637035.56948776034237e-080.302487037661908
DLPFCADediting_1102165chr4_108744751_-0.421587951368429-0.04580643498687780.133322265195004-0.08544757248979195.73248660659315e-080.30221386623355
DLPFCADediting_1102170chr4_108744849_-0.1169287873299190.08922758261263750.4821011328050150.0400694150973493.47324008682897e-080.306919425579826
TCXADediting_1102206chr4_108758120_-0.3424844637198020.07804195248122960.551722407653819-0.04897687180441462.90370393659838e-050.334291227579519
TCXADediting_1102208chr4_108758130_-0.6624956794838670.03592666951944740.347252275049444-0.07727677199560844.53035563085278e-050.326572587620572
DLPFCADediting_1102224chr4_108759279_-0.818619581193747-0.01307681697025720.0809358118693944-0.0992813869723456.43793978365773e-120.377185760200055
TCXADediting_1102225chr4_108759349_-0.976414619083090.002434266897471870.0637039117990259-0.151789893911172.63675921245023e-050.335937769314711

check button Correlation between ADAR gene expression and this gene's expression
TissueADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFC3.09005040087048e-070.2857468601657660.004076681259069040.1626970891653622.47327777929136e-080.31006165720336
AC1.34628660042727e-300.6432896855507344.15672294433125e-150.4694690549935661.3765321237746e-370.696316082542448
PCC5.36466322935909e-070.3532680765445230.00119831214653660.2326879601830582.65432815671014e-110.4581680600239
CER0.004996960345078420.2280880594027440.937132374024818-0.006494343839571992.44205792452175e-100.487754136332753
FP1.12927343865248e-060.355370044648730.001335699981585060.2386614547418739.96310576625046e-070.357053775888322
PG1.79158752246507e-250.6687699191457266.43840882859288e-110.455544763694120.1039056202179890.119617147792041
STG4.4275704076638e-060.4772674413794560.0302602518692120.2365806972603080.02518632500027460.244192684208487

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Relation with AD stages for ETNPPL

check button Correlation between AD stages and RNA editing frequency
TissueADeditomIDpositionP-valCoeff.
TCXADediting_1102155chr4_108744076_-0.001556716304154090.303616546403464
TCXADediting_1102157chr4_108744094_-0.001671193117567430.301722795336678
TCXADediting_1102206chr4_108758120_-9.88095722355571e-050.369102530531778
TCXADediting_1102208chr4_108758130_-0.001485004651524010.304868297577459
TCXADediting_1102209chr4_108758156_-0.0004568845144939190.334523820091992
TCXADediting_1102213chr4_108758218_-0.0002433794064534990.349228972909513
TCXADediting_1102225chr4_108759349_-0.001502450744120920.304558799669088

check button Correlation between AD stages and this gene's expression
TissueP-valCoeff.
CER0.0003189428702263840.339934984502201
TCX3.12963055922966e-070.472629562390565

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RelatedDrugs for ETNPPL

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ETNPPL

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource
ETNPPLC0036341Schizophrenia2PSYGENET