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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for IPPK |
 Gene summary |
| Gene information | Gene symbol | IPPK | Gene ID | 64768 |
| Gene name | inositol-pentakisphosphate 2-kinase | |
| Synonyms | C9orf12|INSP5K2|IP5K|IPK1|bA476B13.1 | |
| Cytomap | 9q22.31 | |
| Type of gene | protein-coding | |
| Description | inositol-pentakisphosphate 2-kinaseIPK1 homologbA476B13.1 (novel protein)inositol 1,3,4,5,6-pentakisphosphate 2-kinaseins(1,3,4,5,6)P5 2-kinaseinsP5 2-kinase | |
| Modification date | 20200313 | |
| UniProtAcc | Q9H8X2, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| IPPK | GO:0052746 | inositol phosphorylation | 12084730 |
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RNA A-to-I events for IPPK |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_1479439(92623322, -), ADediting_1479440(92626208, -), ADediting_1479441(92629667, -), ADediting_1479442(92631263, -), ADediting_1479443(92631375, -), ADediting_1479444(92631392, -), ADediting_1479445(92631399, -), ADediting_1479446(92631448, -), ADediting_1479447(92631454, -), ADediting_1479448(92631455, -), ADediting_1479449(92631457, -), ADediting_1479450(92631468, -), ADediting_1479451(92633283, -), ADediting_1479452(92633565, -), ADediting_1479453(92635727, -), ADediting_1479454(92635739, -), ADediting_1479455(92635740, -), ADediting_1479456(92635759, -), ADediting_1479457(92635779, -), ADediting_1479458(92635784, -), ADediting_1479459(92635787, -), ADediting_1479460(92635788, -), ADediting_1479461(92637275, -), ADediting_1479462(92637292, -), ADediting_1479463(92637305, -), ADediting_1479464(92637389, -), ADediting_1594300(92629036, -), ADediting_1594301(92629702, -), ADediting_1594302(92637284, -), ADediting_1674094(92628874, -), ADediting_1674095(92652327, -), ADediting_1674096(92652337, -), |
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RNA editing positional annotations for IPPK using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_1479439 | chr9_92623322_- | intronic |
| ADediting_1479440 | chr9_92626208_- | intronic |
| ADediting_1479441 | chr9_92629667_- | intronic |
| ADediting_1479442 | chr9_92631263_- | intronic |
| ADediting_1479443 | chr9_92631375_- | intronic |
| ADediting_1479444 | chr9_92631392_- | intronic |
| ADediting_1479445 | chr9_92631399_- | intronic |
| ADediting_1479446 | chr9_92631448_- | intronic |
| ADediting_1479447 | chr9_92631454_- | intronic |
| ADediting_1479448 | chr9_92631455_- | intronic |
| ADediting_1479449 | chr9_92631457_- | intronic |
| ADediting_1479450 | chr9_92631468_- | intronic |
| ADediting_1479451 | chr9_92633283_- | intronic |
| ADediting_1479452 | chr9_92633565_- | intronic |
| ADediting_1479453 | chr9_92635727_- | intronic |
| ADediting_1479454 | chr9_92635739_- | intronic |
| ADediting_1479455 | chr9_92635740_- | intronic |
| ADediting_1479456 | chr9_92635759_- | intronic |
| ADediting_1479457 | chr9_92635779_- | intronic |
| ADediting_1479458 | chr9_92635784_- | intronic |
| ADediting_1479459 | chr9_92635787_- | intronic |
| ADediting_1479460 | chr9_92635788_- | intronic |
| ADediting_1479461 | chr9_92637275_- | intronic |
| ADediting_1479462 | chr9_92637292_- | intronic |
| ADediting_1479463 | chr9_92637305_- | intronic |
| ADediting_1479464 | chr9_92637389_- | intronic |
| ADediting_1594300 | chr9_92629036_- | intronic |
| ADediting_1594301 | chr9_92629702_- | intronic |
| ADediting_1594302 | chr9_92637284_- | intronic |
| ADediting_1674094 | chr9_92628874_- | intronic |
| ADediting_1674095 | chr9_92652327_- | intronic |
| ADediting_1674096 | chr9_92652337_- | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_1479439 | chr9_92623322_- | SINE | Alu | Name=AluY |
| ADediting_1479440 | chr9_92626208_- | SINE | Alu | Name=AluY |
| ADediting_1479441 | chr9_92629667_- | SINE | Alu | Name=AluSz6 |
| ADediting_1479442 | chr9_92631263_- | SINE | Alu | Name=AluSg |
| ADediting_1479443 | chr9_92631375_- | SINE | Alu | Name=AluSg |
| ADediting_1479444 | chr9_92631392_- | SINE | Alu | Name=AluSg |
| ADediting_1479445 | chr9_92631399_- | SINE | Alu | Name=AluSg |
| ADediting_1479446 | chr9_92631448_- | SINE | Alu | Name=AluSg |
| ADediting_1479447 | chr9_92631454_- | SINE | Alu | Name=AluSg |
| ADediting_1479448 | chr9_92631455_- | SINE | Alu | Name=AluSg |
| ADediting_1479449 | chr9_92631457_- | SINE | Alu | Name=AluSg |
| ADediting_1479450 | chr9_92631468_- | SINE | Alu | Name=AluSg |
| ADediting_1479451 | chr9_92633283_- | SINE | Alu | Name=AluSc8 |
| ADediting_1479452 | chr9_92633565_- | SINE | Alu | Name=AluJb |
| ADediting_1479453 | chr9_92635727_- | SINE | Alu | Name=AluSz6 |
| ADediting_1479454 | chr9_92635739_- | SINE | Alu | Name=AluSz6 |
| ADediting_1479455 | chr9_92635740_- | SINE | Alu | Name=AluSz6 |
| ADediting_1479456 | chr9_92635759_- | SINE | Alu | Name=AluSz6 |
| ADediting_1479457 | chr9_92635779_- | SINE | Alu | Name=AluSz6 |
| ADediting_1479458 | chr9_92635784_- | SINE | Alu | Name=AluSz6 |
| ADediting_1479459 | chr9_92635787_- | SINE | Alu | Name=AluSz6 |
| ADediting_1479460 | chr9_92635788_- | SINE | Alu | Name=AluSz6 |
| ADediting_1479461 | chr9_92637275_- | SINE | Alu | Name=AluSz |
| ADediting_1479462 | chr9_92637292_- | SINE | Alu | Name=AluSz |
| ADediting_1479463 | chr9_92637305_- | SINE | Alu | Name=AluSz |
| ADediting_1594300 | chr9_92629036_- | SINE | Alu | Name=AluJr |
| ADediting_1594301 | chr9_92629702_- | SINE | Alu | Name=AluSz6 |
| ADediting_1594302 | chr9_92637284_- | SINE | Alu | Name=AluSz |
| ADediting_1674094 | chr9_92628874_- | SINE | Alu | Name=AluSz6 |
| ADediting_1674095 | chr9_92652327_- | SINE | Alu | Name=AluY |
| ADediting_1674096 | chr9_92652337_- | SINE | Alu | Name=AluY |
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RNA A-to-I editing events in the alternative splicing sites for IPPK |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for IPPK |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for IPPK |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for IPPK |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_107020 | chr1_37500952_- | ENSG00000127080.10 | ENST00000287996.8 | IPPK-201 | hsa-miR-5581-3p | chr9 | 92614379 | 92614385 | 7mer-m8 | 92614378 | 92614401 | 150 | -26.25 |
| ADediting_1337758 | chr7_5495892_- | ENSG00000127080.10 | ENST00000287996.8 | IPPK-201 | hsa-miR-589-5p | chr9 | 92615321 | 92615327 | 7mer-m8 | 92615320 | 92615341 | 152 | -22.71 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000127080.10 | ENST00000287996.8 | IPPK-201 | hsa-miR-381-3p | chr9 | 92614081 | 92614087 | 7mer-m8 | 92614080 | 92614101 | 140 | -11.71 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_107020 | chr1_37500952_- | ENSG00000127080.10 | ENST00000287996.8 | IPPK-201 | hsa-miR-5581-3p | chr9 | 92615685 | 92615691 | 7mer-1a | 92615685 | 92615706 | 143 | -20.93 |
| ADediting_107020 | chr1_37500952_- | ENSG00000127080.10 | ENST00000375522.1 | IPPK-202 | hsa-miR-5581-3p | chr9 | 92615685 | 92615691 | 7mer-1a | 92615685 | 92615706 | 143 | -20.93 |
| ADediting_1337758 | chr7_5495892_- | ENSG00000127080.10 | ENST00000287996.8 | IPPK-201 | hsa-miR-589-5p | chr9 | 92614823 | 92614829 | 7mer-m8 | 92614822 | 92614843 | 148 | -17.44 |
| ADediting_496066 | chr15_66496985_- | ENSG00000127080.10 | ENST00000287996.8 | IPPK-201 | hsa-miR-4512 | chr9 | 92614869 | 92614875 | 7mer-m8 | 92614868 | 92614889 | 140 | -21.02 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for IPPK |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for IPPK |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| CER | ADediting_1479456 | chr9_92635759_- | 8.64940492695373e-05 | 0.314966139467248 | 1.26579673505738e-05 | 0.348171222979912 | 0.00111370073259406 | 0.263665910744072 |
| CER | ADediting_1479459 | chr9_92635787_- | 5.35363824042421e-09 | 0.45404968347606 | 1.82482819828158e-07 | 0.410428805778085 | 0.00106172334201624 | 0.264721055922999 |
| CER | ADediting_1479461 | chr9_92637275_- | 4.02468654264257e-08 | 0.429871774530232 | 2.381071173573e-09 | 0.463254303800689 | 0.00510497038552756 | 0.227542599875301 |
| TCX | ADediting_1479461 | chr9_92637275_- | 0.000581557737589916 | 0.277659761171237 | 7.00293226610764e-06 | 0.357680598267349 | 0.57285994182186 | -0.0464010713473532 |
| CER | ADediting_1479462 | chr9_92637292_- | 2.22895807203317e-10 | 0.4886972378169 | 1.70161412423912e-12 | 0.535274694878198 | 0.000825130374311493 | 0.270217437646029 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 2.6219193915268e-42 | 0.673409687388943 | 4.54071005726627e-57 | 0.749279547550327 | 1.37605594966838e-05 | 0.244168639828023 |
| AC | 1.5857373041371e-78 | 0.871035325715094 | 3.8592854435486e-54 | 0.787908230350484 | 6.1114517253491e-17 | 0.496144777279272 |
| PCC | 1.13566109431348e-33 | 0.734621972790371 | 2.19836478843655e-36 | 0.754320020302967 | 0.00266842227563533 | 0.216173255823849 |
| CER | 5.55032249157405e-19 | 0.644600486632988 | 1.54678078981401e-31 | 0.776887585093361 | 0.00011324448439717 | 0.309985884292315 |
| TCX | 8.71718703721134e-30 | 0.762534523473346 | 1.54804211368204e-21 | 0.678094259401144 | 0.00946894229797401 | 0.211222835960555 |
| FP | 1.42807142544052e-30 | 0.727203972202613 | 3.89861726006323e-38 | 0.783013803160539 | 0.00544553206204759 | 0.207515978144843 |
| IFG | 1.36877768566196e-09 | 0.896317321968133 | 7.20895804263341e-07 | 0.814533114187753 | 0.0850140018748636 | 0.351368470510832 |
| PG | 3.89139239220539e-37 | 0.765892230813936 | 7.60906974668622e-28 | 0.692042133121433 | 0.958053364439645 | 0.00388272645665908 |
| STG | 2.42346315317507e-23 | 0.838615665013018 | 2.07289309443946e-21 | 0.818204649219064 | 0.566799817673158 | 0.063381238915417 |
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Relation with AD stages for IPPK |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| CER | ADediting_1479461 | chr9_92637275_- | 0.000188053489559944 | 0.351887413020597 |
| CER | ADediting_1479462 | chr9_92637292_- | 4.53260376663685e-05 | 0.38191454164402 |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 1.49905604132982e-05 | 0.403393183320098 |
| TCX | 0.00106655910402973 | 0.313503752088939 |
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RelatedDrugs for IPPK |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for IPPK |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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