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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for NIPBL-DT |
 Gene summary |
| Gene information | Gene symbol | NIPBL-DT | Gene ID | 646719 |
| Gene name | NIPBL divergent transcript | |
| Synonyms | NIPBL-AS|NIPBL-AS1 | |
| Cytomap | 5p13.2 | |
| Type of gene | ncRNA | |
| Description | NIPBL antisense RNA 1 (head to head) | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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RNA A-to-I events for NIPBL-DT |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_1200314(36868326, -), ADediting_1200315(36868327, -), ADediting_1200316(36868362, -), ADediting_1200317(36868369, -), ADediting_1200318(36868375, -), ADediting_1200319(36868473, -), ADediting_1200320(36868508, -), ADediting_1200321(36868509, -), ADediting_1200322(36868517, -), ADediting_1200323(36868522, -), ADediting_1200324(36869000, -), ADediting_1200325(36869004, -), ADediting_1200326(36869005, -), ADediting_1200327(36872403, -), ADediting_1200328(36872458, -), ADediting_1200329(36872480, -), ADediting_1200330(36872483, -), ADediting_1200331(36872525, -), ADediting_1200332(36872538, -), ADediting_1200333(36872583, -), ADediting_1200334(36872599, -), ADediting_1200335(36872600, -), ADediting_1200336(36872608, -), ADediting_1581451(36865960, -), ADediting_1581452(36865982, -), ADediting_1581453(36867124, -), ADediting_1581454(36867143, -), ADediting_1581455(36867234, -), ADediting_1581456(36872535, -), |
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RNA editing positional annotations for NIPBL-DT using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_1200314 | chr5_36868326_- | ncRNA_intronic |
| ADediting_1200315 | chr5_36868327_- | ncRNA_intronic |
| ADediting_1200316 | chr5_36868362_- | ncRNA_intronic |
| ADediting_1200317 | chr5_36868369_- | ncRNA_intronic |
| ADediting_1200318 | chr5_36868375_- | ncRNA_intronic |
| ADediting_1200319 | chr5_36868473_- | ncRNA_intronic |
| ADediting_1200320 | chr5_36868508_- | ncRNA_intronic |
| ADediting_1200321 | chr5_36868509_- | ncRNA_intronic |
| ADediting_1200322 | chr5_36868517_- | ncRNA_intronic |
| ADediting_1200323 | chr5_36868522_- | ncRNA_intronic |
| ADediting_1200324 | chr5_36869000_- | ncRNA_intronic |
| ADediting_1200325 | chr5_36869004_- | ncRNA_intronic |
| ADediting_1200326 | chr5_36869005_- | ncRNA_intronic |
| ADediting_1200327 | chr5_36872403_- | ncRNA_exonic |
| ADediting_1200328 | chr5_36872458_- | ncRNA_exonic |
| ADediting_1200329 | chr5_36872480_- | ncRNA_exonic |
| ADediting_1200330 | chr5_36872483_- | ncRNA_exonic |
| ADediting_1200331 | chr5_36872525_- | ncRNA_exonic |
| ADediting_1200332 | chr5_36872538_- | ncRNA_exonic |
| ADediting_1200333 | chr5_36872583_- | ncRNA_exonic |
| ADediting_1200334 | chr5_36872599_- | ncRNA_exonic |
| ADediting_1200335 | chr5_36872600_- | ncRNA_exonic |
| ADediting_1200336 | chr5_36872608_- | ncRNA_exonic |
| ADediting_1581451 | chr5_36865960_- | ncRNA_exonic |
| ADediting_1581452 | chr5_36865982_- | ncRNA_exonic |
| ADediting_1581453 | chr5_36867124_- | ncRNA_exonic |
| ADediting_1581454 | chr5_36867143_- | ncRNA_exonic |
| ADediting_1581455 | chr5_36867234_- | ncRNA_exonic |
| ADediting_1581456 | chr5_36872535_- | ncRNA_exonic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_1200314 | chr5_36868326_- | SINE | Alu | Name=AluY |
| ADediting_1200315 | chr5_36868327_- | SINE | Alu | Name=AluY |
| ADediting_1200316 | chr5_36868362_- | SINE | Alu | Name=AluY |
| ADediting_1200317 | chr5_36868369_- | SINE | Alu | Name=AluY |
| ADediting_1200318 | chr5_36868375_- | SINE | Alu | Name=AluY |
| ADediting_1200319 | chr5_36868473_- | SINE | Alu | Name=AluY |
| ADediting_1200320 | chr5_36868508_- | SINE | Alu | Name=AluY |
| ADediting_1200321 | chr5_36868509_- | SINE | Alu | Name=AluY |
| ADediting_1200322 | chr5_36868517_- | SINE | Alu | Name=AluY |
| ADediting_1200323 | chr5_36868522_- | SINE | Alu | Name=AluY |
| ADediting_1200324 | chr5_36869000_- | SINE | Alu | Name=FLAM_C |
| ADediting_1200325 | chr5_36869004_- | SINE | Alu | Name=FLAM_C |
| ADediting_1200326 | chr5_36869005_- | SINE | Alu | Name=FLAM_C |
| ADediting_1200327 | chr5_36872403_- | SINE | Alu | Name=AluY |
| ADediting_1200328 | chr5_36872458_- | SINE | Alu | Name=AluY |
| ADediting_1200329 | chr5_36872480_- | SINE | Alu | Name=AluY |
| ADediting_1200330 | chr5_36872483_- | SINE | Alu | Name=AluY |
| ADediting_1200331 | chr5_36872525_- | SINE | Alu | Name=AluY |
| ADediting_1200332 | chr5_36872538_- | SINE | Alu | Name=AluY |
| ADediting_1200333 | chr5_36872583_- | SINE | Alu | Name=AluY |
| ADediting_1200334 | chr5_36872599_- | SINE | Alu | Name=AluY |
| ADediting_1200335 | chr5_36872600_- | SINE | Alu | Name=AluY |
| ADediting_1200336 | chr5_36872608_- | SINE | Alu | Name=AluY |
| ADediting_1581451 | chr5_36865960_- | SINE | Alu | Name=AluJr |
| ADediting_1581452 | chr5_36865982_- | SINE | Alu | Name=AluJr |
| ADediting_1581453 | chr5_36867124_- | SINE | Alu | Name=AluSz |
| ADediting_1581454 | chr5_36867143_- | SINE | Alu | Name=AluSz |
| ADediting_1581455 | chr5_36867234_- | SINE | Alu | Name=AluSz |
| ADediting_1581456 | chr5_36872535_- | SINE | Alu | Name=AluY |
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RNA A-to-I editing events in the alternative splicing sites for NIPBL-DT |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for NIPBL-DT |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for NIPBL-DT |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for NIPBL-DT |
| RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. |
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| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1200327 | chr5_36872403_- | ENSG00000285967.1 | ENST00000647824.1 | NIPBL-DT-202 | hsa-miR-3189-3p | chr5 | 36872402 | 36872408 | 7mer-m8 | 36872401 | 36872420 | 145 | -22.36 |
| ADediting_1200327 | chr5_36872403_- | ENSG00000285967.1 | ENST00000647824.1 | NIPBL-DT-202 | hsa-miR-6813-3p | chr5 | 36872401 | 36872407 | 7mer-m8 | 36872400 | 36872420 | 140 | -14.88 |
| ADediting_1200327 | chr5_36872403_- | ENSG00000285967.1 | ENST00000649921.1 | NIPBL-DT-203 | hsa-miR-3189-3p | chr5 | 36872402 | 36872408 | 7mer-m8 | 36872401 | 36872420 | 145 | -22.36 |
| ADediting_1200327 | chr5_36872403_- | ENSG00000285967.1 | ENST00000649921.1 | NIPBL-DT-203 | hsa-miR-6813-3p | chr5 | 36872401 | 36872407 | 7mer-m8 | 36872400 | 36872420 | 140 | -14.88 |
| ADediting_1200328 | chr5_36872458_- | ENSG00000285967.1 | ENST00000647824.1 | NIPBL-DT-202 | hsa-miR-3190-5p | chr5 | 36872453 | 36872459 | 7mer-m8 | 36872452 | 36872470 | 152 | -22.63 |
| ADediting_1200328 | chr5_36872458_- | ENSG00000285967.1 | ENST00000647824.1 | NIPBL-DT-202 | hsa-miR-548s | chr5 | 36872454 | 36872460 | 7mer-m8 | 36872453 | 36872475 | 149 | -12.68 |
| ADediting_1200328 | chr5_36872458_- | ENSG00000285967.1 | ENST00000649921.1 | NIPBL-DT-203 | hsa-miR-3190-5p | chr5 | 36872453 | 36872459 | 7mer-m8 | 36872452 | 36872470 | 152 | -22.63 |
| ADediting_1200328 | chr5_36872458_- | ENSG00000285967.1 | ENST00000649921.1 | NIPBL-DT-203 | hsa-miR-548s | chr5 | 36872454 | 36872460 | 7mer-m8 | 36872453 | 36872475 | 149 | -12.68 |
| ADediting_1200331 | chr5_36872525_- | ENSG00000285967.1 | ENST00000647824.1 | NIPBL-DT-202 | hsa-miR-17-3p | chr5 | 36872522 | 36872528 | 7mer-m8 | 36872521 | 36872543 | 154 | -21.02 |
| ADediting_1200331 | chr5_36872525_- | ENSG00000285967.1 | ENST00000649921.1 | NIPBL-DT-203 | hsa-miR-17-3p | chr5 | 36872522 | 36872528 | 7mer-m8 | 36872521 | 36872543 | 154 | -21.02 |
| ADediting_1200332 | chr5_36872538_- | ENSG00000285967.1 | ENST00000647824.1 | NIPBL-DT-202 | hsa-miR-4655-5p | chr5 | 36872535 | 36872542 | 8mer-1a | 36872535 | 36872555 | 168 | -30.79 |
| ADediting_1200332 | chr5_36872538_- | ENSG00000285967.1 | ENST00000649921.1 | NIPBL-DT-203 | hsa-miR-4655-5p | chr5 | 36872535 | 36872542 | 8mer-1a | 36872535 | 36872555 | 168 | -30.79 |
| ADediting_1200333 | chr5_36872583_- | ENSG00000285967.1 | ENST00000647824.1 | NIPBL-DT-202 | hsa-miR-17-3p | chr5 | 36872583 | 36872589 | 7mer-m8 | 36872582 | 36872603 | 150 | -18.16 |
| ADediting_1200333 | chr5_36872583_- | ENSG00000285967.1 | ENST00000647824.1 | NIPBL-DT-202 | hsa-miR-596 | chr5 | 36872580 | 36872586 | 7mer-m8 | 36872579 | 36872599 | 140 | -18.43 |
| ADediting_1200333 | chr5_36872583_- | ENSG00000285967.1 | ENST00000649921.1 | NIPBL-DT-203 | hsa-miR-17-3p | chr5 | 36872583 | 36872589 | 7mer-m8 | 36872582 | 36872603 | 150 | -18.16 |
| ADediting_1200333 | chr5_36872583_- | ENSG00000285967.1 | ENST00000649921.1 | NIPBL-DT-203 | hsa-miR-596 | chr5 | 36872580 | 36872586 | 7mer-m8 | 36872579 | 36872599 | 140 | -18.43 |
| ADediting_1200334 | chr5_36872599_- | ENSG00000285967.1 | ENST00000647824.1 | NIPBL-DT-202 | hsa-miR-3130-3p | chr5 | 36872599 | 36872605 | 7mer-m8 | 36872598 | 36872619 | 146 | -18.52 |
| ADediting_1200334 | chr5_36872599_- | ENSG00000285967.1 | ENST00000647824.1 | NIPBL-DT-202 | hsa-miR-873-3p | chr5 | 36872595 | 36872601 | 7mer-m8 | 36872594 | 36872616 | 145 | -17.9 |
| ADediting_1200334 | chr5_36872599_- | ENSG00000285967.1 | ENST00000649921.1 | NIPBL-DT-203 | hsa-miR-3130-3p | chr5 | 36872599 | 36872605 | 7mer-m8 | 36872598 | 36872619 | 146 | -18.52 |
| ADediting_1200334 | chr5_36872599_- | ENSG00000285967.1 | ENST00000649921.1 | NIPBL-DT-203 | hsa-miR-873-3p | chr5 | 36872595 | 36872601 | 7mer-m8 | 36872594 | 36872616 | 145 | -17.9 |
| ADediting_1581456 | chr5_36872535_- | ENSG00000285967.1 | ENST00000647824.1 | NIPBL-DT-202 | hsa-miR-4269 | chr5 | 36872531 | 36872537 | 7mer-m8 | 36872530 | 36872550 | 143 | -15.82 |
| ADediting_1581456 | chr5_36872535_- | ENSG00000285967.1 | ENST00000647824.1 | NIPBL-DT-202 | hsa-miR-4645-5p | chr5 | 36872530 | 36872536 | 7mer-m8 | 36872529 | 36872547 | 140 | -12.95 |
| ADediting_1581456 | chr5_36872535_- | ENSG00000285967.1 | ENST00000647824.1 | NIPBL-DT-202 | hsa-miR-4673 | chr5 | 36872530 | 36872536 | 7mer-m8 | 36872529 | 36872550 | 148 | -22.66 |
| ADediting_1581456 | chr5_36872535_- | ENSG00000285967.1 | ENST00000647824.1 | NIPBL-DT-202 | hsa-miR-6715b-5p | chr5 | 36872531 | 36872537 | 7mer-m8 | 36872530 | 36872551 | 142 | -20.68 |
| ADediting_1581456 | chr5_36872535_- | ENSG00000285967.1 | ENST00000649921.1 | NIPBL-DT-203 | hsa-miR-4269 | chr5 | 36872531 | 36872537 | 7mer-m8 | 36872530 | 36872550 | 143 | -15.82 |
| ADediting_1581456 | chr5_36872535_- | ENSG00000285967.1 | ENST00000649921.1 | NIPBL-DT-203 | hsa-miR-4645-5p | chr5 | 36872530 | 36872536 | 7mer-m8 | 36872529 | 36872547 | 140 | -12.95 |
| ADediting_1581456 | chr5_36872535_- | ENSG00000285967.1 | ENST00000649921.1 | NIPBL-DT-203 | hsa-miR-4673 | chr5 | 36872530 | 36872536 | 7mer-m8 | 36872529 | 36872550 | 148 | -22.66 |
| ADediting_1581456 | chr5_36872535_- | ENSG00000285967.1 | ENST00000649921.1 | NIPBL-DT-203 | hsa-miR-6715b-5p | chr5 | 36872531 | 36872537 | 7mer-m8 | 36872530 | 36872551 | 142 | -20.68 |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1200328 | chr5_36872458_- | ENSG00000285967.1 | ENST00000647824.1 | NIPBL-DT-202 | hsa-miR-4794 | chr5 | 36872453 | 36872459 | 7mer-m8 | 36872452 | 36872474 | 151 | -21.79 |
| ADediting_1200328 | chr5_36872458_- | ENSG00000285967.1 | ENST00000647824.1 | NIPBL-DT-202 | hsa-miR-664a-5p | chr5 | 36872453 | 36872459 | 7mer-m8 | 36872452 | 36872475 | 141 | -15.05 |
| ADediting_1200328 | chr5_36872458_- | ENSG00000285967.1 | ENST00000649921.1 | NIPBL-DT-203 | hsa-miR-4794 | chr5 | 36872453 | 36872459 | 7mer-m8 | 36872452 | 36872474 | 151 | -21.79 |
| ADediting_1200328 | chr5_36872458_- | ENSG00000285967.1 | ENST00000649921.1 | NIPBL-DT-203 | hsa-miR-664a-5p | chr5 | 36872453 | 36872459 | 7mer-m8 | 36872452 | 36872475 | 141 | -15.05 |
| ADediting_1200329 | chr5_36872480_- | ENSG00000285967.1 | ENST00000647824.1 | NIPBL-DT-202 | hsa-miR-3675-3p | chr5 | 36872475 | 36872481 | 7mer-m8 | 36872474 | 36872495 | 145 | -12.58 |
| ADediting_1200329 | chr5_36872480_- | ENSG00000285967.1 | ENST00000649921.1 | NIPBL-DT-203 | hsa-miR-3675-3p | chr5 | 36872475 | 36872481 | 7mer-m8 | 36872474 | 36872495 | 145 | -12.58 |
| ADediting_1200331 | chr5_36872525_- | ENSG00000285967.1 | ENST00000647824.1 | NIPBL-DT-202 | hsa-miR-20b-3p | chr5 | 36872522 | 36872528 | 7mer-m8 | 36872521 | 36872543 | 152 | -19.41 |
| ADediting_1200331 | chr5_36872525_- | ENSG00000285967.1 | ENST00000649921.1 | NIPBL-DT-203 | hsa-miR-20b-3p | chr5 | 36872522 | 36872528 | 7mer-m8 | 36872521 | 36872543 | 152 | -19.41 |
| ADediting_1200332 | chr5_36872538_- | ENSG00000285967.1 | ENST00000647824.1 | NIPBL-DT-202 | hsa-miR-3150a-3p | chr5 | 36872538 | 36872544 | 7mer-m8 | 36872537 | 36872555 | 146 | -26.05 |
| ADediting_1200332 | chr5_36872538_- | ENSG00000285967.1 | ENST00000647824.1 | NIPBL-DT-202 | hsa-miR-4700-5p | chr5 | 36872537 | 36872543 | 7mer-m8 | 36872536 | 36872559 | 154 | -25.68 |
| ADediting_1200332 | chr5_36872538_- | ENSG00000285967.1 | ENST00000647824.1 | NIPBL-DT-202 | hsa-miR-8089 | chr5 | 36872537 | 36872543 | 7mer-m8 | 36872536 | 36872560 | 151 | -30.21 |
| ADediting_1200332 | chr5_36872538_- | ENSG00000285967.1 | ENST00000649921.1 | NIPBL-DT-203 | hsa-miR-3150a-3p | chr5 | 36872538 | 36872544 | 7mer-m8 | 36872537 | 36872555 | 146 | -26.05 |
| ADediting_1200332 | chr5_36872538_- | ENSG00000285967.1 | ENST00000649921.1 | NIPBL-DT-203 | hsa-miR-4700-5p | chr5 | 36872537 | 36872543 | 7mer-m8 | 36872536 | 36872559 | 154 | -25.68 |
| ADediting_1200332 | chr5_36872538_- | ENSG00000285967.1 | ENST00000649921.1 | NIPBL-DT-203 | hsa-miR-8089 | chr5 | 36872537 | 36872543 | 7mer-m8 | 36872536 | 36872560 | 151 | -30.21 |
| ADediting_1200333 | chr5_36872583_- | ENSG00000285967.1 | ENST00000647824.1 | NIPBL-DT-202 | hsa-miR-4327 | chr5 | 36872581 | 36872587 | 7mer-m8 | 36872580 | 36872599 | 147 | -17.64 |
| ADediting_1200333 | chr5_36872583_- | ENSG00000285967.1 | ENST00000647824.1 | NIPBL-DT-202 | hsa-miR-6516-5p | chr5 | 36872583 | 36872589 | 7mer-m8 | 36872582 | 36872604 | 144 | -16.67 |
| ADediting_1200333 | chr5_36872583_- | ENSG00000285967.1 | ENST00000649921.1 | NIPBL-DT-203 | hsa-miR-4327 | chr5 | 36872581 | 36872587 | 7mer-m8 | 36872580 | 36872599 | 147 | -17.64 |
| ADediting_1200333 | chr5_36872583_- | ENSG00000285967.1 | ENST00000649921.1 | NIPBL-DT-203 | hsa-miR-6516-5p | chr5 | 36872583 | 36872589 | 7mer-m8 | 36872582 | 36872604 | 144 | -16.67 |
| ADediting_1200334 | chr5_36872599_- | ENSG00000285967.1 | ENST00000647824.1 | NIPBL-DT-202 | hsa-miR-25-3p | chr5 | 36872598 | 36872604 | 7mer-m8 | 36872597 | 36872622 | 153 | -24.46 |
| ADediting_1200334 | chr5_36872599_- | ENSG00000285967.1 | ENST00000647824.1 | NIPBL-DT-202 | hsa-miR-32-5p | chr5 | 36872598 | 36872604 | 7mer-m8 | 36872597 | 36872619 | 144 | -12.85 |
| ADediting_1200334 | chr5_36872599_- | ENSG00000285967.1 | ENST00000647824.1 | NIPBL-DT-202 | hsa-miR-363-3p | chr5 | 36872598 | 36872604 | 7mer-m8 | 36872597 | 36872623 | 149 | -19.28 |
| ADediting_1200334 | chr5_36872599_- | ENSG00000285967.1 | ENST00000647824.1 | NIPBL-DT-202 | hsa-miR-367-3p | chr5 | 36872598 | 36872604 | 7mer-m8 | 36872597 | 36872618 | 153 | -17.21 |
| ADediting_1200334 | chr5_36872599_- | ENSG00000285967.1 | ENST00000647824.1 | NIPBL-DT-202 | hsa-miR-5186 | chr5 | 36872595 | 36872601 | 7mer-m8 | 36872594 | 36872614 | 140 | -9.9 |
| ADediting_1200334 | chr5_36872599_- | ENSG00000285967.1 | ENST00000647824.1 | NIPBL-DT-202 | hsa-miR-92b-3p | chr5 | 36872598 | 36872604 | 7mer-m8 | 36872597 | 36872622 | 155 | -23.12 |
| ADediting_1200334 | chr5_36872599_- | ENSG00000285967.1 | ENST00000649921.1 | NIPBL-DT-203 | hsa-miR-25-3p | chr5 | 36872598 | 36872604 | 7mer-m8 | 36872597 | 36872622 | 153 | -24.46 |
| ADediting_1200334 | chr5_36872599_- | ENSG00000285967.1 | ENST00000649921.1 | NIPBL-DT-203 | hsa-miR-32-5p | chr5 | 36872598 | 36872604 | 7mer-m8 | 36872597 | 36872619 | 144 | -12.85 |
| ADediting_1200334 | chr5_36872599_- | ENSG00000285967.1 | ENST00000649921.1 | NIPBL-DT-203 | hsa-miR-363-3p | chr5 | 36872598 | 36872604 | 7mer-m8 | 36872597 | 36872623 | 149 | -19.28 |
| ADediting_1200334 | chr5_36872599_- | ENSG00000285967.1 | ENST00000649921.1 | NIPBL-DT-203 | hsa-miR-367-3p | chr5 | 36872598 | 36872604 | 7mer-m8 | 36872597 | 36872618 | 153 | -17.21 |
| ADediting_1200334 | chr5_36872599_- | ENSG00000285967.1 | ENST00000649921.1 | NIPBL-DT-203 | hsa-miR-5186 | chr5 | 36872595 | 36872601 | 7mer-m8 | 36872594 | 36872614 | 140 | -9.9 |
| ADediting_1200334 | chr5_36872599_- | ENSG00000285967.1 | ENST00000649921.1 | NIPBL-DT-203 | hsa-miR-92b-3p | chr5 | 36872598 | 36872604 | 7mer-m8 | 36872597 | 36872622 | 155 | -23.12 |
| ADediting_1200335 | chr5_36872600_- | ENSG00000285967.1 | ENST00000647824.1 | NIPBL-DT-202 | hsa-miR-25-3p | chr5 | 36872598 | 36872604 | 7mer-m8 | 36872597 | 36872622 | 153 | -24.46 |
| ADediting_1200335 | chr5_36872600_- | ENSG00000285967.1 | ENST00000647824.1 | NIPBL-DT-202 | hsa-miR-32-5p | chr5 | 36872598 | 36872604 | 7mer-m8 | 36872597 | 36872619 | 144 | -12.85 |
| ADediting_1200335 | chr5_36872600_- | ENSG00000285967.1 | ENST00000647824.1 | NIPBL-DT-202 | hsa-miR-363-3p | chr5 | 36872598 | 36872604 | 7mer-m8 | 36872597 | 36872623 | 149 | -19.28 |
| ADediting_1200335 | chr5_36872600_- | ENSG00000285967.1 | ENST00000647824.1 | NIPBL-DT-202 | hsa-miR-367-3p | chr5 | 36872598 | 36872604 | 7mer-m8 | 36872597 | 36872618 | 153 | -17.21 |
| ADediting_1200335 | chr5_36872600_- | ENSG00000285967.1 | ENST00000647824.1 | NIPBL-DT-202 | hsa-miR-5186 | chr5 | 36872595 | 36872601 | 7mer-m8 | 36872594 | 36872614 | 140 | -9.9 |
| ADediting_1200335 | chr5_36872600_- | ENSG00000285967.1 | ENST00000647824.1 | NIPBL-DT-202 | hsa-miR-92b-3p | chr5 | 36872598 | 36872604 | 7mer-m8 | 36872597 | 36872622 | 155 | -23.12 |
| ADediting_1200335 | chr5_36872600_- | ENSG00000285967.1 | ENST00000649921.1 | NIPBL-DT-203 | hsa-miR-25-3p | chr5 | 36872598 | 36872604 | 7mer-m8 | 36872597 | 36872622 | 153 | -24.46 |
| ADediting_1200335 | chr5_36872600_- | ENSG00000285967.1 | ENST00000649921.1 | NIPBL-DT-203 | hsa-miR-32-5p | chr5 | 36872598 | 36872604 | 7mer-m8 | 36872597 | 36872619 | 144 | -12.85 |
| ADediting_1200335 | chr5_36872600_- | ENSG00000285967.1 | ENST00000649921.1 | NIPBL-DT-203 | hsa-miR-363-3p | chr5 | 36872598 | 36872604 | 7mer-m8 | 36872597 | 36872623 | 149 | -19.28 |
| ADediting_1200335 | chr5_36872600_- | ENSG00000285967.1 | ENST00000649921.1 | NIPBL-DT-203 | hsa-miR-367-3p | chr5 | 36872598 | 36872604 | 7mer-m8 | 36872597 | 36872618 | 153 | -17.21 |
| ADediting_1200335 | chr5_36872600_- | ENSG00000285967.1 | ENST00000649921.1 | NIPBL-DT-203 | hsa-miR-5186 | chr5 | 36872595 | 36872601 | 7mer-m8 | 36872594 | 36872614 | 140 | -9.9 |
| ADediting_1200335 | chr5_36872600_- | ENSG00000285967.1 | ENST00000649921.1 | NIPBL-DT-203 | hsa-miR-92b-3p | chr5 | 36872598 | 36872604 | 7mer-m8 | 36872597 | 36872622 | 155 | -23.12 |
| ADediting_1200336 | chr5_36872608_- | ENSG00000285967.1 | ENST00000647824.1 | NIPBL-DT-202 | hsa-miR-324-3p | chr5 | 36872604 | 36872610 | 7mer-m8 | 36872603 | 36872625 | 148 | -24.11 |
| ADediting_1200336 | chr5_36872608_- | ENSG00000285967.1 | ENST00000649921.1 | NIPBL-DT-203 | hsa-miR-324-3p | chr5 | 36872604 | 36872610 | 7mer-m8 | 36872603 | 36872625 | 148 | -24.11 |
| ADediting_1581451 | chr5_36865960_- | ENSG00000285967.1 | ENST00000647750.1 | NIPBL-DT-201 | hsa-miR-10400-3p | chr5 | 36865960 | 36865966 | 7mer-m8 | 36865959 | 36865978 | 141 | -23.04 |
| ADediting_1581451 | chr5_36865960_- | ENSG00000285967.1 | ENST00000647750.1 | NIPBL-DT-201 | hsa-miR-1343-3p | chr5 | 36865957 | 36865963 | 7mer-m8 | 36865956 | 36865979 | 146 | -26.23 |
| ADediting_1581451 | chr5_36865960_- | ENSG00000285967.1 | ENST00000647750.1 | NIPBL-DT-201 | hsa-miR-4674 | chr5 | 36865960 | 36865966 | 7mer-m8 | 36865959 | 36865978 | 148 | -24.84 |
| ADediting_1581451 | chr5_36865960_- | ENSG00000285967.1 | ENST00000647750.1 | NIPBL-DT-201 | hsa-miR-6783-3p | chr5 | 36865957 | 36865963 | 7mer-m8 | 36865956 | 36865982 | 152 | -30.7 |
| ADediting_1581451 | chr5_36865960_- | ENSG00000285967.1 | ENST00000647750.1 | NIPBL-DT-201 | hsa-miR-939-3p | chr5 | 36865957 | 36865964 | 8mer-1a | 36865957 | 36865979 | 146 | -23.71 |
| ADediting_1581452 | chr5_36865982_- | ENSG00000285967.1 | ENST00000647750.1 | NIPBL-DT-201 | hsa-miR-3127-3p | chr5 | 36865978 | 36865984 | 7mer-m8 | 36865977 | 36865998 | 147 | -21.7 |
| ADediting_1581452 | chr5_36865982_- | ENSG00000285967.1 | ENST00000647750.1 | NIPBL-DT-201 | hsa-miR-6756-3p | chr5 | 36865978 | 36865984 | 7mer-m8 | 36865977 | 36865997 | 145 | -20.18 |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1337757 | chr7_5495852_- | ENSG00000285967.1 | ENST00000647824.1 | NIPBL-DT-202 | hsa-miR-589-3p | chr5 | 36872627 | 36872633 | 7mer-m8 | 36872626 | 36875678 | 151 | -15.45 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000285967.1 | ENST00000649921.1 | NIPBL-DT-203 | hsa-miR-589-3p | chr5 | 36872627 | 36872633 | 7mer-m8 | 36872626 | 36872650 | 149 | -15.45 |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000285967.1 | ENST00000647750.1 | NIPBL-DT-201 | hsa-miR-4477b | chr5 | 36864998 | 36865004 | 7mer-m8 | 36864997 | 36865018 | 152 | -17.27 |
| ADediting_1535953 | chr14_101045971_+ | ENSG00000285967.1 | ENST00000649921.1 | NIPBL-DT-203 | hsa-miR-381-3p | chr5 | 36873729 | 36873736 | 8mer-1a | 36873729 | 36873748 | 148 | -11.64 |
| ADediting_1643790 | chr3_121049689_+ | ENSG00000285967.1 | ENST00000649921.1 | NIPBL-DT-203 | hsa-miR-5682 | chr5 | 36873905 | 36873912 | 8mer-1a | 36873905 | 36873926 | 151 | -18.13 |
| ADediting_291761 | chr11_93733708_- | ENSG00000285967.1 | ENST00000647750.1 | NIPBL-DT-201 | hsa-miR-1304-3p | chr5 | 36865751 | 36865758 | 8mer-1a | 36865751 | 36865770 | 155 | -20.06 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000285967.1 | ENST00000649921.1 | NIPBL-DT-203 | hsa-miR-4775 | chr5 | 36873227 | 36873233 | 7mer-m8 | 36873226 | 36873247 | 147 | -10.41 |
| ADediting_98288 | chr1_32086990_+ | ENSG00000285967.1 | ENST00000649921.1 | NIPBL-DT-203 | hsa-miR-5585-3p | chr5 | 36873216 | 36873222 | 7mer-m8 | 36873215 | 36873236 | 140 | -10.23 |
| ADediting_98288 | chr1_32086990_+ | ENSG00000285967.1 | ENST00000649921.1 | NIPBL-DT-203 | hsa-miR-5585-3p | chr5 | 36874609 | 36874616 | 8mer-1a | 36874609 | 36874627 | 152 | -15.62 |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000285967.1 | ENST00000649921.1 | NIPBL-DT-203 | hsa-miR-5688 | chr5 | 36871710 | 36871716 | 7mer-m8 | 36871709 | 36871730 | 154 | -12.67 |
| ADediting_1391023 | chr8_140732605_- | ENSG00000285967.1 | ENST00000649921.1 | NIPBL-DT-203 | hsa-miR-151a-3p | chr5 | 36875253 | 36875259 | 7mer-m8 | 36875252 | 36875272 | 140 | -15.61 |
| ADediting_286380 | chr11_79422188_- | ENSG00000285967.1 | ENST00000649921.1 | NIPBL-DT-203 | hsa-miR-5579-3p | chr5 | 36874350 | 36874356 | 7mer-m8 | 36874349 | 36874371 | 146 | -12.62 |
| ADediting_496066 | chr15_66496985_- | ENSG00000285967.1 | ENST00000649921.1 | NIPBL-DT-203 | hsa-miR-4512 | chr5 | 36875500 | 36875506 | 7mer-m8 | 36875499 | 36875520 | 140 | -16.92 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000285967.1 | ENST00000647750.1 | NIPBL-DT-201 | hsa-miR-4775 | chr5 | 36865605 | 36865611 | 7mer-m8 | 36865604 | 36865625 | 145 | -7.17 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000285967.1 | ENST00000647750.1 | NIPBL-DT-201 | hsa-miR-4775 | chr5 | 36865794 | 36865800 | 7mer-m8 | 36865793 | 36865814 | 150 | -7.08 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000285967.1 | ENST00000647824.1 | NIPBL-DT-202 | hsa-miR-4775 | chr5 | 36872079 | 36872085 | 7mer-m8 | 36872078 | 36872098 | 152 | -5.51 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000285967.1 | ENST00000647824.1 | NIPBL-DT-202 | hsa-miR-4775 | chr5 | 36872210 | 36872216 | 7mer-m8 | 36872209 | 36872230 | 150 | -6.18 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000285967.1 | ENST00000649921.1 | NIPBL-DT-203 | hsa-miR-4775 | chr5 | 36872079 | 36872085 | 7mer-m8 | 36872078 | 36872098 | 152 | -5.51 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000285967.1 | ENST00000649921.1 | NIPBL-DT-203 | hsa-miR-4775 | chr5 | 36872210 | 36872216 | 7mer-m8 | 36872209 | 36872230 | 150 | -6.18 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000285967.1 | ENST00000649921.1 | NIPBL-DT-203 | hsa-miR-4775 | chr5 | 36872860 | 36872866 | 7mer-m8 | 36872859 | 36872880 | 140 | -1.73 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000285967.1 | ENST00000649921.1 | NIPBL-DT-203 | hsa-miR-4775 | chr5 | 36873089 | 36873095 | 7mer-m8 | 36873088 | 36873112 | 149 | -6.96 |
| ADediting_98288 | chr1_32086990_+ | ENSG00000285967.1 | ENST00000649921.1 | NIPBL-DT-203 | hsa-miR-5585-3p | chr5 | 36874198 | 36874204 | 7mer-m8 | 36874197 | 36874218 | 144 | -10.91 |
| ADediting_98289 | chr1_32086992_+ | ENSG00000285967.1 | ENST00000649921.1 | NIPBL-DT-203 | hsa-miR-5585-3p | chr5 | 36874198 | 36874204 | 7mer-m8 | 36874197 | 36874218 | 144 | -10.91 |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for NIPBL-DT |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000647750.1 | lncRNA |  |  |
| ENST00000649921.1 | lncRNA |  |  |
| ENST00000647824.1 | lncRNA |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_1581451 | ENST00000647750.1 | chr5_36865960_- | 1054 | -771.50 | -771.50 | -772.40 |
| ADediting_1581452 | ENST00000647750.1 | chr5_36865982_- | 1032 | -771.60 | -771.50 | -772.40 |
| ADediting_1200327 | ENST00000649921.1 | chr5_36872403_- | 4298 | -1493.30 | -1492.50 | -1499.50 |
| ADediting_1200328 | ENST00000649921.1 | chr5_36872458_- | 4243 | -1491.20 | -1492.50 | -1499.50 |
| ADediting_1200329 | ENST00000649921.1 | chr5_36872480_- | 4221 | -1492.20 | -1492.50 | -1499.50 |
| ADediting_1200330 | ENST00000649921.1 | chr5_36872483_- | 4218 | -1493.30 | -1492.50 | -1499.50 |
| ADediting_1200331 | ENST00000649921.1 | chr5_36872525_- | 4176 | -1493.40 | -1492.50 | -1499.50 |
| ADediting_1581456 | ENST00000649921.1 | chr5_36872535_- | 4166 | -1492.50 | -1492.50 | -1499.50 |
| ADediting_1200332 | ENST00000649921.1 | chr5_36872538_- | 4163 | -1491.80 | -1492.50 | -1499.50 |
| ADediting_1200333 | ENST00000649921.1 | chr5_36872583_- | 4118 | -1492.50 | -1492.50 | -1499.50 |
| ADediting_1200334 | ENST00000649921.1 | chr5_36872599_- | 4102 | -1492.50 | -1492.50 | -1499.50 |
| ADediting_1200335 | ENST00000649921.1 | chr5_36872600_- | 4101 | -1493.50 | -1492.50 | -1499.50 |
| ADediting_1200336 | ENST00000649921.1 | chr5_36872608_- | 4093 | -1491.80 | -1492.50 | -1499.50 |
| ADediting_1200327 | ENST00000647824.1 | chr5_36872403_- | 777 | -388.00 | -387.20 | -397.20 |
| ADediting_1200328 | ENST00000647824.1 | chr5_36872458_- | 722 | -385.90 | -387.20 | -397.20 |
| ADediting_1200329 | ENST00000647824.1 | chr5_36872480_- | 700 | -386.90 | -387.20 | -397.20 |
| ADediting_1200330 | ENST00000647824.1 | chr5_36872483_- | 697 | -388.00 | -387.20 | -397.20 |
| ADediting_1200331 | ENST00000647824.1 | chr5_36872525_- | 655 | -388.10 | -387.20 | -397.20 |
| ADediting_1581456 | ENST00000647824.1 | chr5_36872535_- | 645 | -387.20 | -387.20 | -397.20 |
| ADediting_1200332 | ENST00000647824.1 | chr5_36872538_- | 642 | -386.50 | -387.20 | -397.20 |
| ADediting_1200333 | ENST00000647824.1 | chr5_36872583_- | 597 | -387.20 | -387.20 | -397.20 |
| ADediting_1200334 | ENST00000647824.1 | chr5_36872599_- | 581 | -387.20 | -387.20 | -397.20 |
| ADediting_1200335 | ENST00000647824.1 | chr5_36872600_- | 580 | -388.20 | -387.20 | -397.20 |
| ADediting_1200336 | ENST00000647824.1 | chr5_36872608_- | 572 | -386.50 | -387.20 | -397.20 |
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Relation with ADAR for NIPBL-DT |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| CER | ADediting_1200323 | chr5_36868522_- | 2.6886974873946e-07 | 0.405239359204293 | 0.000173659243760144 | 0.301898075162188 | 0.660193341082095 | 0.0361879322354149 |
| DLPFC | ADediting_1200334 | chr5_36872599_- | 0.00207525474392094 | 0.174253432426997 | 0.466306881774346 | 0.0415259873714982 | 5.82658861413862e-08 | 0.302059550444002 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 1.60061394233628e-19 | 0.482974986063749 | 3.37507378311409e-07 | 0.284854987131235 | 5.96870561455178e-30 | 0.585797094490184 |
| AC | 1.2174669609888e-62 | 0.822230890409508 | 1.54422966001918e-47 | 0.755963942672678 | 1.09292168726987e-05 | 0.274174566656208 |
| PCC | 2.3315833858926e-26 | 0.67112211651223 | 1.3053309202539e-25 | 0.663596703143353 | 0.000910321120976725 | 0.238102126414141 |
| CER | 5.88061442915194e-23 | 0.694981244780786 | 6.55910317631405e-10 | 0.477361310457153 | 0.853098955605859 | -0.0152453843540299 |
| TCX | 6.27113989271677e-15 | 0.581242302870777 | 7.43339771594766e-05 | 0.317728111692543 | 0.0173509720537451 | 0.194032868386575 |
| FP | 3.04299765738625e-10 | 0.44966427453522 | 3.95068262166695e-18 | 0.590778914383379 | 0.348141267644004 | 0.0707313165171183 |
| PG | 1.07963315676014e-40 | 0.788470023868298 | 7.58095008594414e-24 | 0.651496456297531 | 0.805277660452604 | -0.0181970941642897 |
| STG | 2.37821234389078e-15 | 0.73257333153282 | 3.35497125511976e-11 | 0.645590822906819 | 0.089671661860924 | 0.186338783693373 |
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Relation with AD stages for NIPBL-DT |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
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RelatedDrugs for NIPBL-DT |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NIPBL-DT |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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