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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for NFKBIZ |
 Gene summary |
| Gene information | Gene symbol | NFKBIZ | Gene ID | 64332 |
| Gene name | NFKB inhibitor zeta | |
| Synonyms | IKBZ|INAP|MAIL | |
| Cytomap | 3q12.3 | |
| Type of gene | protein-coding | |
| Description | NF-kappa-B inhibitor zetaI-kappa-B-zetaIL-1 inducible nuclear ankyrin-repeat proteinIkappa B-zeta variant 3IkappaB-zetaikB-zetaikappaBzetamolecule possessing ankyrin repeats induced by lipopolysaccharidenuclear factor of kappa light polypeptide ge | |
| Modification date | 20200313 | |
| UniProtAcc | Q9BYH8, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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RNA A-to-I events for NFKBIZ |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_1008978(101831666, +), ADediting_1008979(101831699, +), ADediting_1008980(101831735, +), ADediting_1008981(101831741, +), ADediting_1008982(101831758, +), ADediting_1008983(101831759, +), ADediting_1008984(101831770, +), ADediting_1008985(101831854, +), ADediting_1008986(101831875, +), ADediting_1008987(101831892, +), ADediting_1008988(101831945, +), ADediting_1008989(101832123, +), ADediting_1008990(101832139, +), ADediting_1008991(101832144, +), ADediting_1008992(101832186, +), ADediting_1008993(101832199, +), ADediting_1008995(101843179, +), ADediting_1008996(101843180, +), ADediting_1008997(101843225, +), ADediting_1008998(101843244, +), ADediting_1008999(101843253, +), ADediting_1009000(101843296, +), ADediting_1009001(101843322, +), ADediting_1009002(101843332, +), |
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RNA editing positional annotations for NFKBIZ using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_1008978 | chr3_101831666_+ | intronic |
| ADediting_1008979 | chr3_101831699_+ | intronic |
| ADediting_1008980 | chr3_101831735_+ | intronic |
| ADediting_1008981 | chr3_101831741_+ | intronic |
| ADediting_1008982 | chr3_101831758_+ | intronic |
| ADediting_1008983 | chr3_101831759_+ | intronic |
| ADediting_1008984 | chr3_101831770_+ | intronic |
| ADediting_1008985 | chr3_101831854_+ | intronic |
| ADediting_1008986 | chr3_101831875_+ | intronic |
| ADediting_1008987 | chr3_101831892_+ | intronic |
| ADediting_1008988 | chr3_101831945_+ | intronic |
| ADediting_1008989 | chr3_101832123_+ | intronic |
| ADediting_1008990 | chr3_101832139_+ | intronic |
| ADediting_1008991 | chr3_101832144_+ | intronic |
| ADediting_1008992 | chr3_101832186_+ | intronic |
| ADediting_1008993 | chr3_101832199_+ | intronic |
| ADediting_1008995 | chr3_101843179_+ | intronic |
| ADediting_1008996 | chr3_101843180_+ | intronic |
| ADediting_1008997 | chr3_101843225_+ | intronic |
| ADediting_1008998 | chr3_101843244_+ | intronic |
| ADediting_1008999 | chr3_101843253_+ | intronic |
| ADediting_1009000 | chr3_101843296_+ | intronic |
| ADediting_1009001 | chr3_101843322_+ | intronic |
| ADediting_1009002 | chr3_101843332_+ | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_1008978 | chr3_101831666_+ | SINE | Alu | Name=AluSx |
| ADediting_1008979 | chr3_101831699_+ | SINE | Alu | Name=AluSx |
| ADediting_1008980 | chr3_101831735_+ | SINE | Alu | Name=AluSx |
| ADediting_1008981 | chr3_101831741_+ | SINE | Alu | Name=AluSx |
| ADediting_1008982 | chr3_101831758_+ | SINE | Alu | Name=AluSx |
| ADediting_1008983 | chr3_101831759_+ | SINE | Alu | Name=AluSx |
| ADediting_1008984 | chr3_101831770_+ | SINE | Alu | Name=AluSx |
| ADediting_1008985 | chr3_101831854_+ | SINE | Alu | Name=AluSx |
| ADediting_1008986 | chr3_101831875_+ | SINE | Alu | Name=AluSx |
| ADediting_1008987 | chr3_101831892_+ | SINE | Alu | Name=AluSx |
| ADediting_1008988 | chr3_101831945_+ | SINE | Alu | Name=AluJr |
| ADediting_1008989 | chr3_101832123_+ | SINE | Alu | Name=AluJr |
| ADediting_1008990 | chr3_101832139_+ | SINE | Alu | Name=AluJr |
| ADediting_1008991 | chr3_101832144_+ | SINE | Alu | Name=AluJr |
| ADediting_1008992 | chr3_101832186_+ | SINE | Alu | Name=AluJr |
| ADediting_1008993 | chr3_101832199_+ | SINE | Alu | Name=AluJr |
| ADediting_1008995 | chr3_101843179_+ | SINE | Alu | Name=AluJr4 |
| ADediting_1008996 | chr3_101843180_+ | SINE | Alu | Name=AluJr4 |
| ADediting_1008997 | chr3_101843225_+ | SINE | Alu | Name=AluJr4 |
| ADediting_1008998 | chr3_101843244_+ | SINE | Alu | Name=AluJr4 |
| ADediting_1008999 | chr3_101843253_+ | SINE | Alu | Name=AluJr4 |
| ADediting_1009000 | chr3_101843296_+ | SINE | Alu | Name=AluJr4 |
| ADediting_1009001 | chr3_101843322_+ | SINE | Alu | Name=AluJr4 |
| ADediting_1009002 | chr3_101843332_+ | SINE | Alu | Name=AluJr4 |
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RNA A-to-I editing events in the alternative splicing sites for NFKBIZ |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for NFKBIZ |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for NFKBIZ |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for NFKBIZ |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1337757 | chr7_5495852_- | ENSG00000144802.11 | ENST00000326172.9 | NFKBIZ-202 | hsa-miR-589-3p | chr3 | 101860211 | 101860217 | 7mer-m8 | 101860195 | 101860218 | 156 | -18.25 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000144802.11 | ENST00000394054.6 | NFKBIZ-203 | hsa-miR-589-3p | chr3 | 101860211 | 101860217 | 7mer-m8 | 101860195 | 101860218 | 156 | -18.25 |
| ADediting_1391023 | chr8_140732605_- | ENSG00000144802.11 | ENST00000326172.9 | NFKBIZ-202 | hsa-miR-151a-3p | chr3 | 101860968 | 101860974 | 7mer-m8 | 101860957 | 101860975 | 141 | -12.03 |
| ADediting_1391023 | chr8_140732605_- | ENSG00000144802.11 | ENST00000394054.6 | NFKBIZ-203 | hsa-miR-151a-3p | chr3 | 101860968 | 101860974 | 7mer-m8 | 101860957 | 101860975 | 141 | -12.03 |
| ADediting_1535951 | chr14_100874558_+ | ENSG00000144802.11 | ENST00000326172.9 | NFKBIZ-202 | hsa-miR-337-3p | chr3 | 101860449 | 101860455 | 7mer-m8 | 101860433 | 101860456 | 144 | -17.46 |
| ADediting_1535951 | chr14_100874558_+ | ENSG00000144802.11 | ENST00000394054.6 | NFKBIZ-203 | hsa-miR-337-3p | chr3 | 101860449 | 101860455 | 7mer-m8 | 101860433 | 101860456 | 144 | -17.46 |
| ADediting_98289 | chr1_32086992_+ | ENSG00000144802.11 | ENST00000326172.9 | NFKBIZ-202 | hsa-miR-5585-3p | chr3 | 101860972 | 101860978 | 7mer-m8 | 101860955 | 101860979 | 152 | -17.73 |
| ADediting_98289 | chr1_32086992_+ | ENSG00000144802.11 | ENST00000394054.6 | NFKBIZ-203 | hsa-miR-5585-3p | chr3 | 101860972 | 101860978 | 7mer-m8 | 101860955 | 101860979 | 152 | -17.73 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_107020 | chr1_37500952_- | ENSG00000144802.11 | ENST00000326172.9 | NFKBIZ-202 | hsa-miR-5581-3p | chr3 | 101860483 | 101860490 | 8mer-1a | 101860467 | 101860490 | 150 | -17.5 |
| ADediting_107020 | chr1_37500952_- | ENSG00000144802.11 | ENST00000394054.6 | NFKBIZ-203 | hsa-miR-5581-3p | chr3 | 101860483 | 101860490 | 8mer-1a | 101860467 | 101860490 | 150 | -17.5 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000144802.11 | ENST00000326172.9 | NFKBIZ-202 | hsa-miR-589-3p | chr3 | 101860536 | 101860542 | 7mer-m8 | 101860520 | 101860543 | 148 | -10.18 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000144802.11 | ENST00000394054.6 | NFKBIZ-203 | hsa-miR-589-3p | chr3 | 101860536 | 101860542 | 7mer-m8 | 101860520 | 101860543 | 148 | -10.18 |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000144802.11 | ENST00000326172.9 | NFKBIZ-202 | hsa-miR-4477b | chr3 | 101859905 | 101859912 | 8mer-1a | 101859891 | 101859912 | 154 | -13.68 |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000144802.11 | ENST00000394054.6 | NFKBIZ-203 | hsa-miR-4477b | chr3 | 101859905 | 101859912 | 8mer-1a | 101859891 | 101859912 | 154 | -13.68 |
| ADediting_1471004 | chr9_63819627_+ | ENSG00000144802.11 | ENST00000326172.9 | NFKBIZ-202 | hsa-miR-4477b | chr3 | 101859905 | 101859912 | 8mer-1a | 101859891 | 101859912 | 154 | -13.68 |
| ADediting_1471004 | chr9_63819627_+ | ENSG00000144802.11 | ENST00000394054.6 | NFKBIZ-203 | hsa-miR-4477b | chr3 | 101859905 | 101859912 | 8mer-1a | 101859891 | 101859912 | 154 | -13.68 |
| ADediting_1535953 | chr14_101045971_+ | ENSG00000144802.11 | ENST00000326172.9 | NFKBIZ-202 | hsa-miR-381-3p | chr3 | 101860937 | 101860943 | 7mer-m8 | 101860923 | 101860944 | 145 | -11.8 |
| ADediting_1535953 | chr14_101045971_+ | ENSG00000144802.11 | ENST00000394054.6 | NFKBIZ-203 | hsa-miR-381-3p | chr3 | 101860937 | 101860943 | 7mer-m8 | 101860923 | 101860944 | 145 | -11.8 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000144802.11 | ENST00000326172.9 | NFKBIZ-202 | hsa-miR-381-3p | chr3 | 101860937 | 101860943 | 7mer-m8 | 101860923 | 101860944 | 145 | -11.8 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000144802.11 | ENST00000394054.6 | NFKBIZ-203 | hsa-miR-381-3p | chr3 | 101860937 | 101860943 | 7mer-m8 | 101860923 | 101860944 | 145 | -11.8 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000144802.11 | ENST00000326172.9 | NFKBIZ-202 | hsa-miR-641 | chr3 | 101860907 | 101860913 | 7mer-m8 | 101860889 | 101860914 | 151 | -11.09 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000144802.11 | ENST00000394054.6 | NFKBIZ-203 | hsa-miR-641 | chr3 | 101860907 | 101860913 | 7mer-m8 | 101860889 | 101860914 | 151 | -11.09 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000144802.11 | ENST00000326172.9 | NFKBIZ-202 | hsa-miR-641 | chr3 | 101860907 | 101860913 | 7mer-m8 | 101860889 | 101860914 | 151 | -11.09 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000144802.11 | ENST00000394054.6 | NFKBIZ-203 | hsa-miR-641 | chr3 | 101860907 | 101860913 | 7mer-m8 | 101860889 | 101860914 | 151 | -11.09 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for NFKBIZ |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for NFKBIZ |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| CER | ADediting_1008985 | chr3_101831854_+ | 0.000879139913945781 | 0.268845929589831 | 1.28875514381874e-05 | 0.347877609503141 | 0.895565313044385 | 0.0108078801935824 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 8.1470494114567e-13 | 0.391797092006473 | 0.0030863497940382 | 0.167547413585371 | 6.50787259896479e-15 | 0.423371059833103 |
| CER | 1.50509977701331e-11 | 0.515314773965034 | 7.6992758977704e-12 | 0.521592299086336 | 0.00866594290643776 | 0.21363393783322 |
| TCX | 9.10252279602337e-07 | 0.388311223042752 | 0.514981258165838 | 0.0535721388227006 | 0.000122433705503199 | 0.308527330455779 |
| IFG | 0.0446092335557281 | 0.404999970204992 | 0.0201500595780392 | 0.461737690939175 | 0.116535439890786 | 0.321954879366908 |
| PG | 2.92521729125108e-08 | 0.392824149259633 | 1.67284157324784e-08 | 0.399118802136216 | 0.858454606567995 | 0.013164831747808 |
| STG | 0.135341029150498 | 0.164292085255319 | 0.776647742907993 | 0.0314162435054701 | 0.0048873678939564 | 0.304313418980275 |
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Relation with AD stages for NFKBIZ |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 7.22217344915602e-05 | 0.372404425008179 |
| TCX | 6.46072851612501e-07 | 0.4613207463352 |
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RelatedDrugs for NFKBIZ |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NFKBIZ |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| NFKBIZ | C0009405 | Hereditary Nonpolyposis Colorectal Neoplasms | 1 | CLINGEN |
| NFKBIZ | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| NFKBIZ | C1112155 | Hereditary non-polyposis colorectal cancer syndrome | 1 | CLINGEN |
| NFKBIZ | C1333990 | Hereditary Nonpolyposis Colorectal Cancer | 1 | CLINGEN |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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