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Center for Computational Systems Medicine
Soverview

Gene summary

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RNA A-to-I events

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Differntial gene expression between RNA A-to-I edited versus non-edited samples

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Protein coding region RNA A-to-I editings

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The effects of the RNA editing to the miRNA binding sites

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The effects of the RNA editing to the stability of the RNA structures

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Relation with ADAR

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Relation with AD stages

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Related drugs with this gene

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Related diseases with this gene


Gene summary for BLOC1S5

check button Gene summary
Gene informationGene symbol

BLOC1S5

Gene ID

63915

Gene namebiogenesis of lysosomal organelles complex 1 subunit 5
SynonymsBLOS5|MU|MUTED
Cytomap

6p24.3

Type of geneprotein-coding
Descriptionbiogenesis of lysosome-related organelles complex 1 subunit 5BLOC-1 subunit 5biogenesis of lysosomal organelles complex-1, subunit 5, mutedmuted homologprotein Muted homolog
Modification date20200313
UniProtAcc

Q8TDH9,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
BLOC1S5

GO:0032402

melanosome transport

17182842

BLOC1S5

GO:0035646

endosome to melanosome transport

17182842

BLOC1S5

GO:0050942

positive regulation of pigment cell differentiation

17182842


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RNA A-to-I events for BLOC1S5

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
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check button RNA A-to-I editing events in AD.
ADediting_1277501(8014296, -), ADediting_1277502(8014334, -), ADediting_1277503(8014339, -), ADediting_1277504(8014346, -), ADediting_1277505(8014376, -), ADediting_1277506(8014379, -), ADediting_1277507(8014380, -), ADediting_1277508(8014389, -), ADediting_1277509(8014395, -), ADediting_1277510(8014398, -), ADediting_1277511(8014402, -), ADediting_1277512(8014411, -), ADediting_1277513(8014412, -), ADediting_1277514(8014438, -), ADediting_1277515(8014441, -), ADediting_1277516(8014442, -), ADediting_1277517(8014443, -), ADediting_1277518(8014444, -), ADediting_1277519(8014445, -), ADediting_1277520(8014447, -), ADediting_1277521(8014452, -), ADediting_1277522(8014453, -), ADediting_1277523(8014456, -), ADediting_1277524(8014467, -), ADediting_1277525(8014477, -), ADediting_1277526(8014492, -), ADediting_1277527(8014493, -), ADediting_1277528(8014501, -), ADediting_1277529(8014505, -), ADediting_1277530(8014506, -), ADediting_1277531(8014520, -), ADediting_1277532(8014524, -), ADediting_1277533(8014540, -), ADediting_1277534(8014546, -), ADediting_1277535(8014547, -), ADediting_1277536(8014553, -), ADediting_1277537(8017356, -), ADediting_1277538(8019337, -), ADediting_1277539(8019448, -), ADediting_1277540(8019487, -), ADediting_1277541(8019488, -), ADediting_1277544(8023407, -), ADediting_1277545(8023452, -), ADediting_1277546(8023468, -), ADediting_1277547(8023478, -), ADediting_1277548(8023507, -), ADediting_1277549(8024281, -), ADediting_1277616(8049939, -), ADediting_1277617(8052703, -), ADediting_1277618(8052767, -), ADediting_1277619(8052773, -), ADediting_1584554(8014366, -), ADediting_1584555(8014530, -), ADediting_1662643(8014371, -), ADediting_1662644(8014406, -),

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RNA editing positional annotations for BLOC1S5 using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_1277501chr6_8014296_-UTR3
ADediting_1277502chr6_8014334_-UTR3
ADediting_1277503chr6_8014339_-UTR3
ADediting_1277504chr6_8014346_-UTR3
ADediting_1277505chr6_8014376_-UTR3
ADediting_1277506chr6_8014379_-UTR3
ADediting_1277507chr6_8014380_-UTR3
ADediting_1277508chr6_8014389_-UTR3
ADediting_1277509chr6_8014395_-UTR3
ADediting_1277510chr6_8014398_-UTR3
ADediting_1277511chr6_8014402_-UTR3
ADediting_1277512chr6_8014411_-UTR3
ADediting_1277513chr6_8014412_-UTR3
ADediting_1277514chr6_8014438_-UTR3
ADediting_1277515chr6_8014441_-UTR3
ADediting_1277516chr6_8014442_-UTR3
ADediting_1277517chr6_8014443_-UTR3
ADediting_1277518chr6_8014444_-UTR3
ADediting_1277519chr6_8014445_-UTR3
ADediting_1277520chr6_8014447_-UTR3
ADediting_1277521chr6_8014452_-UTR3
ADediting_1277522chr6_8014453_-UTR3
ADediting_1277523chr6_8014456_-UTR3
ADediting_1277524chr6_8014467_-UTR3
ADediting_1277525chr6_8014477_-UTR3
ADediting_1277526chr6_8014492_-UTR3
ADediting_1277527chr6_8014493_-UTR3
ADediting_1277528chr6_8014501_-UTR3
ADediting_1277529chr6_8014505_-UTR3
ADediting_1277530chr6_8014506_-UTR3
ADediting_1277531chr6_8014520_-UTR3
ADediting_1277532chr6_8014524_-UTR3
ADediting_1277533chr6_8014540_-UTR3
ADediting_1277534chr6_8014546_-UTR3
ADediting_1277535chr6_8014547_-UTR3
ADediting_1277536chr6_8014553_-UTR3
ADediting_1277537chr6_8017356_-intronic
ADediting_1277538chr6_8019337_-intronic
ADediting_1277539chr6_8019448_-intronic
ADediting_1277540chr6_8019487_-intronic
ADediting_1277541chr6_8019488_-intronic
ADediting_1277544chr6_8023407_-intronic
ADediting_1277545chr6_8023452_-intronic
ADediting_1277546chr6_8023468_-intronic
ADediting_1277547chr6_8023478_-intronic
ADediting_1277548chr6_8023507_-intronic
ADediting_1277549chr6_8024281_-intronic
ADediting_1277616chr6_8049939_-intronic
ADediting_1277617chr6_8052703_-intronic
ADediting_1277618chr6_8052767_-intronic
ADediting_1277619chr6_8052773_-intronic
ADediting_1584554chr6_8014366_-UTR3
ADediting_1584555chr6_8014530_-UTR3
ADediting_1662643chr6_8014371_-UTR3
ADediting_1662644chr6_8014406_-UTR3

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_1277501chr6_8014296_-SINEAluName=AluSz
ADediting_1277502chr6_8014334_-SINEAluName=AluSz
ADediting_1277503chr6_8014339_-SINEAluName=AluSz
ADediting_1277504chr6_8014346_-SINEAluName=AluSz
ADediting_1277505chr6_8014376_-SINEAluName=AluSz
ADediting_1277506chr6_8014379_-SINEAluName=AluSz
ADediting_1277507chr6_8014380_-SINEAluName=AluSz
ADediting_1277508chr6_8014389_-SINEAluName=AluSz
ADediting_1277509chr6_8014395_-SINEAluName=AluSz
ADediting_1277510chr6_8014398_-SINEAluName=AluSz
ADediting_1277511chr6_8014402_-SINEAluName=AluSz
ADediting_1277512chr6_8014411_-SINEAluName=AluSz
ADediting_1277513chr6_8014412_-SINEAluName=AluSz
ADediting_1277514chr6_8014438_-SINEAluName=AluSz
ADediting_1277515chr6_8014441_-SINEAluName=AluSz
ADediting_1277516chr6_8014442_-SINEAluName=AluSz
ADediting_1277517chr6_8014443_-SINEAluName=AluSz
ADediting_1277518chr6_8014444_-SINEAluName=AluSz
ADediting_1277519chr6_8014445_-SINEAluName=AluSz
ADediting_1277520chr6_8014447_-SINEAluName=AluSz
ADediting_1277521chr6_8014452_-SINEAluName=AluSz
ADediting_1277522chr6_8014453_-SINEAluName=AluSz
ADediting_1277523chr6_8014456_-SINEAluName=AluSz
ADediting_1277524chr6_8014467_-SINEAluName=AluSz
ADediting_1277525chr6_8014477_-SINEAluName=AluSz
ADediting_1277526chr6_8014492_-SINEAluName=AluSz
ADediting_1277527chr6_8014493_-SINEAluName=AluSz
ADediting_1277528chr6_8014501_-SINEAluName=AluSz
ADediting_1277529chr6_8014505_-SINEAluName=AluSz
ADediting_1277530chr6_8014506_-SINEAluName=AluSz
ADediting_1277531chr6_8014520_-SINEAluName=AluSz
ADediting_1277532chr6_8014524_-SINEAluName=AluSz
ADediting_1277533chr6_8014540_-SINEAluName=AluSz
ADediting_1277534chr6_8014546_-SINEAluName=AluSz
ADediting_1277535chr6_8014547_-SINEAluName=AluSz
ADediting_1277536chr6_8014553_-SINEAluName=AluSz
ADediting_1277537chr6_8017356_-SINEAluName=AluSg7
ADediting_1277538chr6_8019337_-SINEAluName=AluSq2
ADediting_1277539chr6_8019448_-SINEAluName=AluSq2
ADediting_1277540chr6_8019487_-SINEAluName=AluSq2
ADediting_1277541chr6_8019488_-SINEAluName=AluSq2
ADediting_1277544chr6_8023407_-SINEAluName=AluSx
ADediting_1277545chr6_8023452_-SINEAluName=AluSx
ADediting_1277546chr6_8023468_-SINEAluName=AluSx
ADediting_1277547chr6_8023478_-SINEAluName=AluSx
ADediting_1277548chr6_8023507_-SINEAluName=AluSx
ADediting_1277549chr6_8024281_-SINEAluName=AluSx1
ADediting_1277616chr6_8049939_-SINEAluName=AluJb
ADediting_1277617chr6_8052703_-SINEAluName=AluY
ADediting_1277618chr6_8052767_-SINEAluName=AluY
ADediting_1277619chr6_8052773_-SINEAluName=AluY
ADediting_1584554chr6_8014366_-SINEAluName=AluSz
ADediting_1584555chr6_8014530_-SINEAluName=AluSz
ADediting_1662643chr6_8014371_-SINEAluName=AluSz
ADediting_1662644chr6_8014406_-SINEAluName=AluSz

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RNA A-to-I editing events in the alternative splicing sites for BLOC1S5

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for BLOC1S5

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
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check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
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check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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ADeditome IDChrPositoingSkipped exonENSGENSTs

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Protein coding region RNA A-to-I editings for BLOC1S5

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for BLOC1S5

check buttonRNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
all structure

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1277503chr6_8014339_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-4715-3pchr6801433480143407mer-m880143338014359167-35.01
ADediting_1277504chr6_8014346_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-4690-3pchr6801434180143488mer-1a80143418014360161-30.09
ADediting_1277504chr6_8014346_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-5685chr6801434180143488mer-1a80143418014364150-22.78
ADediting_1277505chr6_8014376_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-8053chr6801437480143807mer-m880143738014397153-21.97
ADediting_1277509chr6_8014395_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-125a-5pchr6801439580144017mer-m880143948014417141-16.11
ADediting_1277509chr6_8014395_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-125b-5pchr6801439580144017mer-m880143948014415141-16.11
ADediting_1277509chr6_8014395_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-4319chr6801439580144017mer-m880143948014410142-17.68
ADediting_1277509chr6_8014395_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-6846-3pchr6801439280143987mer-m880143918014411140-13.95
ADediting_1277511chr6_8014402_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-1207-3pchr6801440280144087mer-m880144018014418140-12.56
ADediting_1277511chr6_8014402_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-646chr6801440080144067mer-m880143998014417145-13.63
ADediting_1277512chr6_8014411_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-8052chr6801440680144127mer-1a80144068014428143-22.12
ADediting_1277513chr6_8014412_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-513b-5pchr6801441180144177mer-m880144108014431149-14.71
ADediting_1277513chr6_8014412_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-638chr6801440680144127mer-1a80144068014430159-30.58
ADediting_1277516chr6_8014442_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-6844chr6801444180144477mer-m880144408014461155-7.49
ADediting_1277517chr6_8014443_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-578chr6801444180144477mer-m880144408014460148-9.14
ADediting_1277517chr6_8014443_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-643chr6801444280144498mer-1a80144428014464143-11.13
ADediting_1277518chr6_8014444_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-4742-3pchr6801444380144508mer-1a80144438014465142-9.18
ADediting_1277520chr6_8014447_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-153-5pchr6801444780144537mer-m880144468014468144-8.17
ADediting_1277520chr6_8014447_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-3680-3pchr6801444280144498mer-1a80144428014464140-14.25
ADediting_1277521chr6_8014452_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-325chr6801445180144588mer-1a80144518014473141-10.26
ADediting_1277522chr6_8014453_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-222-5pchr6801445180144588mer-1a80144518014472140-9.13
ADediting_1277522chr6_8014453_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-30a-3pchr6801444980144568mer-1a80144498014473150-12.52
ADediting_1277522chr6_8014453_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-30d-3pchr6801444980144568mer-1a80144498014471149-12.11
ADediting_1277522chr6_8014453_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-30e-3pchr6801444980144568mer-1a80144498014473150-14.55
ADediting_1277522chr6_8014453_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-936chr6801445280144598mer-1a80144528014474159-22.47
ADediting_1277523chr6_8014456_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-374b-3pchr6801445180144588mer-1a80144518014473147-12.57
ADediting_1277524chr6_8014467_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-412-3pchr6801446780144737mer-m880144668014493154-21.03
ADediting_1277524chr6_8014467_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-4508chr6801446280144687mer-m880144618014477140-21.85
ADediting_1277524chr6_8014467_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-6754-3pchr6801446780144737mer-m880144668014486144-15.76
ADediting_1277525chr6_8014477_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-3190-5pchr6801447780144837mer-m880144768014496154-18.52
ADediting_1277526chr6_8014492_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-12113chr6801449280144987mer-m880144918014514150-16.53
ADediting_1277526chr6_8014492_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-4539chr6801449280144987mer-m880144918014509145-14.9
ADediting_1277529chr6_8014505_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-372-5pchr6801450580145117mer-m880145048014526145-19.22
ADediting_1277530chr6_8014506_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-3145-5pchr6801450380145097mer-m880145028014523146-11.72
ADediting_1277530chr6_8014506_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-519d-5pchr6801450480145107mer-m880145038014526156-19.49
ADediting_1277531chr6_8014520_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-4707-3pchr6801451780145237mer-m880145168014537154-23.87
ADediting_1277532chr6_8014524_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-10396a-3pchr6801452080145278mer-1a80145208014540156-26.99
ADediting_1277532chr6_8014524_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-10396b-3pchr6801452080145278mer-1a80145208014541156-27.05
ADediting_1277532chr6_8014524_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-1913chr6801451980145257mer-m880145188014539147-22.1
ADediting_1277532chr6_8014524_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-4707-5pchr6801452280145287mer-m880145218014545142-27.23
ADediting_1277533chr6_8014540_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-302a-3pchr6801453580145417mer-m880145348014555147-15.45
ADediting_1277533chr6_8014540_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-302b-3pchr6801453580145417mer-m880145348014554145-9.54
ADediting_1277533chr6_8014540_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-302c-3pchr6801453580145417mer-m880145348014554149-11.96
ADediting_1277533chr6_8014540_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-302d-3pchr6801453580145417mer-m880145348014561152-14.53
ADediting_1277533chr6_8014540_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-302echr6801453580145417mer-m880145348014550141-8.62
ADediting_1277533chr6_8014540_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-372-3pchr6801453580145417mer-m880145348014561159-20.52
ADediting_1277533chr6_8014540_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-373-3pchr6801453580145417mer-m880145348014557164-22.27
ADediting_1277533chr6_8014540_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-512-3pchr6801453680145427mer-m880145358014559151-18.66
ADediting_1277533chr6_8014540_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-520a-3pchr6801453580145417mer-m880145348014555140-11.04
ADediting_1277533chr6_8014540_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-520b-3pchr6801453580145417mer-m880145348014553141-16.53
ADediting_1277533chr6_8014540_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-520c-3pchr6801453580145417mer-m880145348014554146-16.53
ADediting_1277533chr6_8014540_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-520d-3pchr6801453580145417mer-m880145348014557142-15.59
ADediting_1277533chr6_8014540_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-520e-3pchr6801453580145417mer-m880145348014554140-13.33
ADediting_1277533chr6_8014540_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-7160-5pchr6801453880145447mer-1a80145388014558144-25.98
ADediting_1277534chr6_8014546_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-3672chr6801454080145478mer-1a80145408014565150-13.26
ADediting_1277534chr6_8014546_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-6864-3pchr6801454080145478mer-1a80145408014560142-10.97
ADediting_1277535chr6_8014547_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-513a-5pchr6801454680145527mer-m880145458014562144-17.77
ADediting_1584555chr6_8014530_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-10392-3pchr6801452480145318mer-1a80145248014547142-21.88

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1277501chr6_8014296_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-3198chr6801429680143027mer-m880142958014316140-14.27
ADediting_1277501chr6_8014296_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-4309chr6801429680143027mer-m880142958014312145-15.52
ADediting_1277501chr6_8014296_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-4534chr6801429480143007mer-m880142938014309140-14.2
ADediting_1277501chr6_8014296_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-6514-5pchr6801429580143017mer-m880142948014319147-15.81
ADediting_1277501chr6_8014296_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-8082chr6801429480143007mer-m880142938014315141-22.09
ADediting_1277502chr6_8014334_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-3085-5pchr6801433180143388mer-1a80143318014354153-21.44
ADediting_1277505chr6_8014376_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-125a-3pchr6801437180143788mer-1a80143718014390155-22.69
ADediting_1277509chr6_8014395_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-1200chr6801439580144017mer-m880143948014415141-17.86
ADediting_1277510chr6_8014398_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-1200chr6801439580144017mer-m880143948014415141-17.86
ADediting_1277510chr6_8014398_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-6869-5pchr6801439880144047mer-m880143978014419146-18.16
ADediting_1277511chr6_8014402_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-6869-5pchr6801439880144047mer-m880143978014419146-18.16
ADediting_1277512chr6_8014411_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-5089-5pchr6801440680144127mer-m880144058014425148-17.3
ADediting_1277514chr6_8014438_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-4735-5pchr6801443780144437mer-m880144368014457140-5.48
ADediting_1277514chr6_8014438_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-664b-5pchr6801443480144407mer-m880144338014456140-15.87
ADediting_1277515chr6_8014441_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-4735-5pchr6801443780144437mer-m880144368014457140-5.48
ADediting_1277516chr6_8014442_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-4735-5pchr6801443780144437mer-m880144368014457140-5.48
ADediting_1277523chr6_8014456_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-6832-5pchr6801445580144617mer-m880144548014476142-16.66
ADediting_1277524chr6_8014467_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-193b-5pchr6801446380144697mer-m880144628014483142-20.42
ADediting_1277525chr6_8014477_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-4716-5pchr6801447280144787mer-m880144718014492140-12.82
ADediting_1277525chr6_8014477_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-4781-3pchr6801447480144807mer-m880144738014491152-18.4
ADediting_1277526chr6_8014492_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-12116chr6801448780144937mer-m880144868014506147-20.15
ADediting_1277529chr6_8014505_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-607chr6801450580145117mer-m880145048014521144-8.19
ADediting_1277530chr6_8014506_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-607chr6801450580145117mer-m880145048014521144-8.19
ADediting_1277531chr6_8014520_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-4485-5pchr6801451480145218mer-1a80145148014529150-22.24
ADediting_1277531chr6_8014520_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-6747-3pchr6801451880145247mer-m880145178014538150-22.04
ADediting_1277534chr6_8014546_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-10399-5pchr6801454580145517mer-m880145448014565148-10
ADediting_1277534chr6_8014546_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-6504-3pchr6801454580145517mer-m880145448014565149-15.11
ADediting_1277535chr6_8014547_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-10399-5pchr6801454580145517mer-m880145448014565148-10
ADediting_1277535chr6_8014547_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-6504-3pchr6801454580145517mer-m880145448014565149-15.11
ADediting_1277536chr6_8014553_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-3934-5pchr6801454980145557mer-m880145488014570155-23.69
ADediting_1277536chr6_8014553_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-552-3pchr6801454780145548mer-1a80145478014567140-14.09
ADediting_1584554chr6_8014366_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-1200chr6801436380143697mer-m880143628014390141-26.05
ADediting_1584555chr6_8014530_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-150-5pchr6801452980145357mer-m880145288014549140-15.81
ADediting_1584555chr6_8014530_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-6778-3pchr6801452780145337mer-m880145268014546143-13.97
ADediting_1662643chr6_8014371_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-5000-5pchr6801436880143747mer-m880143678014386151-15.4
ADediting_1662644chr6_8014406_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-5089-5pchr6801440680144127mer-m880144058014425148-17.3
ADediting_1662644chr6_8014406_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-6506-5pchr6801440580144117mer-m880144048014426144-14.51

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1391023chr8_140732605_-ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-151a-3pchr6801457980145868mer-1a80145798014599140-12.6
ADediting_1535953chr14_101045971_+ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-381-3pchr6801362480136318mer-1a80136248013647147-14.36
ADediting_1535954chr14_101045974_+ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-381-3pchr6801362480136318mer-1a80136248013647147-14.36
ADediting_843620chr2_207754818_+ENSG00000188428.20ENST00000397457.7BLOC1S5-202hsa-miR-4775chr6801367780136837mer-1a80136778013699149-12.34

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for BLOC1S5

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.
ENST00000397457.7protein_codingSoverviewSoverview

check button RNA A-to-I editing in miRNA.
ADeditom_IDENSTmir_IDEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in mRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI
ADediting_1277501ENST00000397457.7chr6_8014296_-1930-734.50-732.10-768.50
ADediting_1277502ENST00000397457.7chr6_8014334_-1892-731.70-732.10-768.50
ADediting_1277503ENST00000397457.7chr6_8014339_-1887-731.50-732.10-768.50
ADediting_1277504ENST00000397457.7chr6_8014346_-1880-735.60-732.10-768.50
ADediting_1584554ENST00000397457.7chr6_8014366_-1860-731.40-732.10-768.50
ADediting_1662643ENST00000397457.7chr6_8014371_-1855-732.10-732.10-768.50
ADediting_1277505ENST00000397457.7chr6_8014376_-1850-732.30-732.10-768.50
ADediting_1277506ENST00000397457.7chr6_8014379_-1847-732.80-732.10-768.50
ADediting_1277507ENST00000397457.7chr6_8014380_-1846-732.60-732.10-768.50
ADediting_1277508ENST00000397457.7chr6_8014389_-1837-733.00-732.10-768.50
ADediting_1277509ENST00000397457.7chr6_8014395_-1831-734.20-732.10-768.50
ADediting_1277510ENST00000397457.7chr6_8014398_-1828-732.60-732.10-768.50
ADediting_1277511ENST00000397457.7chr6_8014402_-1824-732.80-732.10-768.50
ADediting_1662644ENST00000397457.7chr6_8014406_-1820-737.30-732.10-768.50
ADediting_1277512ENST00000397457.7chr6_8014411_-1815-737.20-732.10-768.50
ADediting_1277513ENST00000397457.7chr6_8014412_-1814-734.00-732.10-768.50
ADediting_1277514ENST00000397457.7chr6_8014438_-1788-732.70-732.10-768.50
ADediting_1277515ENST00000397457.7chr6_8014441_-1785-732.10-732.10-768.50
ADediting_1277516ENST00000397457.7chr6_8014442_-1784-733.20-732.10-768.50
ADediting_1277517ENST00000397457.7chr6_8014443_-1783-733.50-732.10-768.50
ADediting_1277518ENST00000397457.7chr6_8014444_-1782-733.60-732.10-768.50
ADediting_1277519ENST00000397457.7chr6_8014445_-1781-732.80-732.10-768.50
ADediting_1277520ENST00000397457.7chr6_8014447_-1779-732.80-732.10-768.50
ADediting_1277521ENST00000397457.7chr6_8014452_-1774-733.50-732.10-768.50
ADediting_1277522ENST00000397457.7chr6_8014453_-1773-735.50-732.10-768.50
ADediting_1277523ENST00000397457.7chr6_8014456_-1770-732.10-732.10-768.50
ADediting_1277524ENST00000397457.7chr6_8014467_-1759-732.60-732.10-768.50
ADediting_1277525ENST00000397457.7chr6_8014477_-1749-731.60-732.10-768.50
ADediting_1277526ENST00000397457.7chr6_8014492_-1734-732.10-732.10-768.50
ADediting_1277527ENST00000397457.7chr6_8014493_-1733-732.10-732.10-768.50
ADediting_1277528ENST00000397457.7chr6_8014501_-1725-731.30-732.10-768.50
ADediting_1277529ENST00000397457.7chr6_8014505_-1721-732.10-732.10-768.50
ADediting_1277530ENST00000397457.7chr6_8014506_-1720-732.10-732.10-768.50
ADediting_1277531ENST00000397457.7chr6_8014520_-1706-731.40-732.10-768.50
ADediting_1277532ENST00000397457.7chr6_8014524_-1702-733.00-732.10-768.50
ADediting_1584555ENST00000397457.7chr6_8014530_-1696-732.60-732.10-768.50
ADediting_1277533ENST00000397457.7chr6_8014540_-1686-732.30-732.10-768.50
ADediting_1277534ENST00000397457.7chr6_8014546_-1680-732.44-732.10-768.50
ADediting_1277535ENST00000397457.7chr6_8014547_-1679-731.20-732.10-768.50
ADediting_1277536ENST00000397457.7chr6_8014553_-1673-736.20-732.10-768.50

check button RNA A-to-I editing in lncRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for BLOC1S5

check button Correlation between ADAR gene expression and RNA editing frequency
TissueADeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)

check button Correlation between ADAR gene expression and this gene's expression
TissueADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFC3.13599147031481e-220.5132301991965632.15798018530188e-050.2387306331045753.3377181367424e-280.57085911416776
AC2.4817696596844e-530.7842699426205128.86991953821339e-310.6448099927998663.73083970575278e-170.499118173765879
PCC9.74477735308831e-140.5046820247782096.24672431680913e-110.4504079295140560.00012491417436110.274048943963213
CER8.21640967994061e-430.8488416932773282.03223974975794e-180.6366045432324140.009909672342159990.209975283104768
TCX8.46969524661044e-110.4985191632471590.9453711393080990.005641844362520031.18519086373263e-140.576364069197984
FP7.17632282518784e-240.6626488338058891.34779345751219e-140.5354834834471661.9467237811319e-080.405608215025799
PG3.17962669555787e-380.7730805461808574.08821087778699e-170.5655488835315350.2024333672791680.093888166231801
STG3.31600673601471e-070.5230656999558830.0004002128901521790.3775007756786930.01253772845409960.271339849830438

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Relation with AD stages for BLOC1S5

check button Correlation between AD stages and RNA editing frequency
TissueADeditomIDpositionP-valCoeff.

check button Correlation between AD stages and this gene's expression
TissueP-valCoeff.
TCX1.14730257196697e-090.548556754397645

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RelatedDrugs for BLOC1S5

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for BLOC1S5

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource