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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for SLC22A23 |
 Gene summary |
| Gene information | Gene symbol | SLC22A23 | Gene ID | 63027 |
| Gene name | solute carrier family 22 member 23 | |
| Synonyms | C6orf85 | |
| Cytomap | 6p25.2 | |
| Type of gene | protein-coding | |
| Description | solute carrier family 22 member 23ion transporter protein | |
| Modification date | 20200313 | |
| UniProtAcc | A1A5C7, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
Top |
RNA A-to-I events for SLC22A23 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_1254520(3313776, -), ADediting_1254521(3313804, -), ADediting_1254522(3313848, -), ADediting_1254523(3313929, -), ADediting_1254524(3313943, -), ADediting_1254525(3313966, -), ADediting_1254526(3313969, -), ADediting_1254527(3313982, -), ADediting_1254528(3313985, -), ADediting_1254529(3313990, -), ADediting_1254530(3313996, -), ADediting_1254531(3314010, -), ADediting_1254532(3315675, -), ADediting_1254533(3315700, -), ADediting_1254534(3315716, -), ADediting_1254535(3315831, -), ADediting_1254536(3316311, -), ADediting_1254537(3316698, -), ADediting_1254538(3316709, -), ADediting_1254539(3316714, -), ADediting_1254540(3316721, -), ADediting_1254541(3316740, -), ADediting_1254542(3316753, -), ADediting_1254543(3316762, -), ADediting_1254544(3316766, -), ADediting_1254545(3316785, -), ADediting_1254546(3316788, -), ADediting_1254547(3316801, -), ADediting_1254548(3316804, -), ADediting_1254549(3316816, -), ADediting_1254550(3316817, -), ADediting_1254551(3316826, -), ADediting_1254552(3316837, -), ADediting_1254553(3316841, -), ADediting_1254554(3316842, -), ADediting_1254555(3316851, -), ADediting_1254556(3316856, -), ADediting_1254557(3316857, -), ADediting_1254558(3316880, -), ADediting_1254559(3320490, -), ADediting_1254560(3320518, -), ADediting_1254561(3320526, -), ADediting_1254562(3320544, -), ADediting_1254563(3320545, -), ADediting_1254564(3320558, -), ADediting_1254565(3320587, -), ADediting_1254566(3321920, -), ADediting_1254567(3321957, -), ADediting_1254568(3321973, -), ADediting_1254569(3321979, -), ADediting_1254570(3321980, -), ADediting_1254571(3321981, -), ADediting_1254572(3321992, -), ADediting_1254573(3321996, -), ADediting_1254574(3322013, -), ADediting_1254575(3322025, -), ADediting_1254631(3334428, -), ADediting_1254632(3335839, -), ADediting_1254680(3398785, -), ADediting_1254681(3398945, -), ADediting_1254685(3400016, -), ADediting_1254686(3400151, -), ADediting_1254687(3401216, -), ADediting_1254688(3401255, -), ADediting_1254689(3401278, -), ADediting_1254690(3401291, -), ADediting_1254691(3401292, -), ADediting_1254692(3401307, -), ADediting_1254714(3420920, -), ADediting_1254715(3420922, -), ADediting_1255296(3430832, -), ADediting_1255614(3436273, -), ADediting_1255615(3436274, -), ADediting_1255616(3436335, -), ADediting_1255617(3436339, -), ADediting_1255618(3436387, -), ADediting_1255628(3436400, -), ADediting_1255629(3436408, -), ADediting_1255630(3436427, -), ADediting_1255670(3437421, -), ADediting_1255671(3437464, -), ADediting_1255672(3437488, -), ADediting_1255688(3437567, -), ADediting_1255689(3437577, -), ADediting_1255702(3437833, -), ADediting_1255703(3437886, -), ADediting_1255704(3437912, -), ADediting_1255933(3447793, -), ADediting_1255934(3447874, -), ADediting_1255996(3450508, -), ADediting_1255997(3450572, -), ADediting_1255998(3450577, -), ADediting_1255999(3451263, -), ADediting_1256000(3451334, -), ADediting_1256001(3451335, -), ADediting_1256002(3451398, -), ADediting_1256003(3451400, -), ADediting_1256004(3451464, -), ADediting_1256005(3451469, -), ADediting_1256006(3452342, -), ADediting_1256007(3452375, -), ADediting_1256008(3452401, -), ADediting_1256009(3452408, -), ADediting_1256010(3452471, -), ADediting_1256011(3452477, -), ADediting_1256012(3452487, -), ADediting_1256013(3452547, -), ADediting_1256014(3452575, -), ADediting_1583563(3320581, -), ADediting_1583564(3334282, -), ADediting_1583565(3334286, -), ADediting_1661188(3401275, -), ADediting_1661189(3420963, -), ADediting_1661190(3420973, -), ADediting_1661191(3420979, -), ADediting_1661221(3452499, -), ADediting_1661222(3452523, -), |
Top |
RNA editing positional annotations for SLC22A23 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_1254520 | chr6_3313776_- | intronic |
| ADediting_1254521 | chr6_3313804_- | intronic |
| ADediting_1254522 | chr6_3313848_- | intronic |
| ADediting_1254523 | chr6_3313929_- | intronic |
| ADediting_1254524 | chr6_3313943_- | intronic |
| ADediting_1254525 | chr6_3313966_- | intronic |
| ADediting_1254526 | chr6_3313969_- | intronic |
| ADediting_1254527 | chr6_3313982_- | intronic |
| ADediting_1254528 | chr6_3313985_- | intronic |
| ADediting_1254529 | chr6_3313990_- | intronic |
| ADediting_1254530 | chr6_3313996_- | intronic |
| ADediting_1254531 | chr6_3314010_- | intronic |
| ADediting_1254532 | chr6_3315675_- | intronic |
| ADediting_1254533 | chr6_3315700_- | intronic |
| ADediting_1254534 | chr6_3315716_- | intronic |
| ADediting_1254535 | chr6_3315831_- | intronic |
| ADediting_1254536 | chr6_3316311_- | intronic |
| ADediting_1254537 | chr6_3316698_- | intronic |
| ADediting_1254538 | chr6_3316709_- | intronic |
| ADediting_1254539 | chr6_3316714_- | intronic |
| ADediting_1254540 | chr6_3316721_- | intronic |
| ADediting_1254541 | chr6_3316740_- | intronic |
| ADediting_1254542 | chr6_3316753_- | intronic |
| ADediting_1254543 | chr6_3316762_- | intronic |
| ADediting_1254544 | chr6_3316766_- | intronic |
| ADediting_1254545 | chr6_3316785_- | intronic |
| ADediting_1254546 | chr6_3316788_- | intronic |
| ADediting_1254547 | chr6_3316801_- | intronic |
| ADediting_1254548 | chr6_3316804_- | intronic |
| ADediting_1254549 | chr6_3316816_- | intronic |
| ADediting_1254550 | chr6_3316817_- | intronic |
| ADediting_1254551 | chr6_3316826_- | intronic |
| ADediting_1254552 | chr6_3316837_- | intronic |
| ADediting_1254553 | chr6_3316841_- | intronic |
| ADediting_1254554 | chr6_3316842_- | intronic |
| ADediting_1254555 | chr6_3316851_- | intronic |
| ADediting_1254556 | chr6_3316856_- | intronic |
| ADediting_1254557 | chr6_3316857_- | intronic |
| ADediting_1254558 | chr6_3316880_- | intronic |
| ADediting_1254559 | chr6_3320490_- | intronic |
| ADediting_1254560 | chr6_3320518_- | intronic |
| ADediting_1254561 | chr6_3320526_- | intronic |
| ADediting_1254562 | chr6_3320544_- | intronic |
| ADediting_1254563 | chr6_3320545_- | intronic |
| ADediting_1254564 | chr6_3320558_- | intronic |
| ADediting_1254565 | chr6_3320587_- | intronic |
| ADediting_1254566 | chr6_3321920_- | intronic |
| ADediting_1254567 | chr6_3321957_- | intronic |
| ADediting_1254568 | chr6_3321973_- | intronic |
| ADediting_1254569 | chr6_3321979_- | intronic |
| ADediting_1254570 | chr6_3321980_- | intronic |
| ADediting_1254571 | chr6_3321981_- | intronic |
| ADediting_1254572 | chr6_3321992_- | intronic |
| ADediting_1254573 | chr6_3321996_- | intronic |
| ADediting_1254574 | chr6_3322013_- | intronic |
| ADediting_1254575 | chr6_3322025_- | intronic |
| ADediting_1254631 | chr6_3334428_- | intronic |
| ADediting_1254632 | chr6_3335839_- | intronic |
| ADediting_1254680 | chr6_3398785_- | intronic |
| ADediting_1254681 | chr6_3398945_- | intronic |
| ADediting_1254685 | chr6_3400016_- | intronic |
| ADediting_1254686 | chr6_3400151_- | intronic |
| ADediting_1254687 | chr6_3401216_- | intronic |
| ADediting_1254688 | chr6_3401255_- | intronic |
| ADediting_1254689 | chr6_3401278_- | intronic |
| ADediting_1254690 | chr6_3401291_- | intronic |
| ADediting_1254691 | chr6_3401292_- | intronic |
| ADediting_1254692 | chr6_3401307_- | intronic |
| ADediting_1254714 | chr6_3420920_- | intronic |
| ADediting_1254715 | chr6_3420922_- | intronic |
| ADediting_1255296 | chr6_3430832_- | intronic |
| ADediting_1255614 | chr6_3436273_- | intronic |
| ADediting_1255615 | chr6_3436274_- | intronic |
| ADediting_1255616 | chr6_3436335_- | intronic |
| ADediting_1255617 | chr6_3436339_- | intronic |
| ADediting_1255618 | chr6_3436387_- | intronic |
| ADediting_1255628 | chr6_3436400_- | intronic |
| ADediting_1255629 | chr6_3436408_- | intronic |
| ADediting_1255630 | chr6_3436427_- | intronic |
| ADediting_1255670 | chr6_3437421_- | intronic |
| ADediting_1255671 | chr6_3437464_- | intronic |
| ADediting_1255672 | chr6_3437488_- | intronic |
| ADediting_1255688 | chr6_3437567_- | intronic |
| ADediting_1255689 | chr6_3437577_- | intronic |
| ADediting_1255702 | chr6_3437833_- | intronic |
| ADediting_1255703 | chr6_3437886_- | intronic |
| ADediting_1255704 | chr6_3437912_- | intronic |
| ADediting_1255933 | chr6_3447793_- | intronic |
| ADediting_1255934 | chr6_3447874_- | intronic |
| ADediting_1255996 | chr6_3450508_- | intronic |
| ADediting_1255997 | chr6_3450572_- | intronic |
| ADediting_1255998 | chr6_3450577_- | intronic |
| ADediting_1255999 | chr6_3451263_- | intronic |
| ADediting_1256000 | chr6_3451334_- | intronic |
| ADediting_1256001 | chr6_3451335_- | intronic |
| ADediting_1256002 | chr6_3451398_- | intronic |
| ADediting_1256003 | chr6_3451400_- | intronic |
| ADediting_1256004 | chr6_3451464_- | intronic |
| ADediting_1256005 | chr6_3451469_- | intronic |
| ADediting_1256006 | chr6_3452342_- | intronic |
| ADediting_1256007 | chr6_3452375_- | intronic |
| ADediting_1256008 | chr6_3452401_- | intronic |
| ADediting_1256009 | chr6_3452408_- | intronic |
| ADediting_1256010 | chr6_3452471_- | intronic |
| ADediting_1256011 | chr6_3452477_- | intronic |
| ADediting_1256012 | chr6_3452487_- | intronic |
| ADediting_1256013 | chr6_3452547_- | intronic |
| ADediting_1256014 | chr6_3452575_- | intronic |
| ADediting_1583563 | chr6_3320581_- | intronic |
| ADediting_1583564 | chr6_3334282_- | intronic |
| ADediting_1583565 | chr6_3334286_- | intronic |
| ADediting_1661188 | chr6_3401275_- | intronic |
| ADediting_1661189 | chr6_3420963_- | intronic |
| ADediting_1661190 | chr6_3420973_- | intronic |
| ADediting_1661191 | chr6_3420979_- | intronic |
| ADediting_1661221 | chr6_3452499_- | intronic |
| ADediting_1661222 | chr6_3452523_- | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_1254520 | chr6_3313776_- | SINE | Alu | Name=AluSp |
| ADediting_1254521 | chr6_3313804_- | SINE | Alu | Name=AluSp |
| ADediting_1254522 | chr6_3313848_- | SINE | Alu | Name=AluSp |
| ADediting_1254523 | chr6_3313929_- | SINE | Alu | Name=AluSp |
| ADediting_1254524 | chr6_3313943_- | SINE | Alu | Name=AluSp |
| ADediting_1254525 | chr6_3313966_- | SINE | Alu | Name=AluSp |
| ADediting_1254526 | chr6_3313969_- | SINE | Alu | Name=AluSp |
| ADediting_1254527 | chr6_3313982_- | SINE | Alu | Name=AluSp |
| ADediting_1254528 | chr6_3313985_- | SINE | Alu | Name=AluSp |
| ADediting_1254529 | chr6_3313990_- | SINE | Alu | Name=AluSp |
| ADediting_1254530 | chr6_3313996_- | SINE | Alu | Name=AluSp |
| ADediting_1254531 | chr6_3314010_- | SINE | Alu | Name=AluSp |
| ADediting_1254532 | chr6_3315675_- | SINE | Alu | Name=AluY |
| ADediting_1254533 | chr6_3315700_- | SINE | Alu | Name=AluY |
| ADediting_1254534 | chr6_3315716_- | SINE | Alu | Name=AluY |
| ADediting_1254535 | chr6_3315831_- | SINE | Alu | Name=AluY |
| ADediting_1254537 | chr6_3316698_- | SINE | Alu | Name=AluJr |
| ADediting_1254538 | chr6_3316709_- | SINE | Alu | Name=AluJr |
| ADediting_1254539 | chr6_3316714_- | SINE | Alu | Name=AluJr |
| ADediting_1254540 | chr6_3316721_- | SINE | Alu | Name=AluJr |
| ADediting_1254541 | chr6_3316740_- | SINE | Alu | Name=AluJr |
| ADediting_1254542 | chr6_3316753_- | SINE | Alu | Name=AluJr |
| ADediting_1254543 | chr6_3316762_- | SINE | Alu | Name=AluJr |
| ADediting_1254544 | chr6_3316766_- | SINE | Alu | Name=AluJr |
| ADediting_1254545 | chr6_3316785_- | SINE | Alu | Name=AluJr |
| ADediting_1254546 | chr6_3316788_- | SINE | Alu | Name=AluJr |
| ADediting_1254547 | chr6_3316801_- | SINE | Alu | Name=AluJr |
| ADediting_1254548 | chr6_3316804_- | SINE | Alu | Name=AluJr |
| ADediting_1254549 | chr6_3316816_- | SINE | Alu | Name=AluJr |
| ADediting_1254550 | chr6_3316817_- | SINE | Alu | Name=AluJr |
| ADediting_1254551 | chr6_3316826_- | SINE | Alu | Name=AluJr |
| ADediting_1254552 | chr6_3316837_- | SINE | Alu | Name=AluJr |
| ADediting_1254553 | chr6_3316841_- | SINE | Alu | Name=AluJr |
| ADediting_1254554 | chr6_3316842_- | SINE | Alu | Name=AluJr |
| ADediting_1254555 | chr6_3316851_- | SINE | Alu | Name=AluJr |
| ADediting_1254556 | chr6_3316856_- | SINE | Alu | Name=AluJr |
| ADediting_1254557 | chr6_3316857_- | SINE | Alu | Name=AluJr |
| ADediting_1254558 | chr6_3316880_- | SINE | Alu | Name=AluJr |
| ADediting_1254631 | chr6_3334428_- | SINE | Alu | Name=AluSq2 |
| ADediting_1254632 | chr6_3335839_- | SINE | Alu | Name=AluYk3 |
| ADediting_1254680 | chr6_3398785_- | SINE | Alu | Name=AluJr |
| ADediting_1254681 | chr6_3398945_- | SINE | Alu | Name=AluJr |
| ADediting_1254685 | chr6_3400016_- | SINE | Alu | Name=AluSq2 |
| ADediting_1254686 | chr6_3400151_- | SINE | Alu | Name=AluSq2 |
| ADediting_1254687 | chr6_3401216_- | SINE | Alu | Name=AluSx1 |
| ADediting_1254688 | chr6_3401255_- | SINE | Alu | Name=AluSx1 |
| ADediting_1254689 | chr6_3401278_- | SINE | Alu | Name=AluSx1 |
| ADediting_1254690 | chr6_3401291_- | SINE | Alu | Name=AluSx1 |
| ADediting_1254691 | chr6_3401292_- | SINE | Alu | Name=AluSx1 |
| ADediting_1254692 | chr6_3401307_- | SINE | Alu | Name=AluSx1 |
| ADediting_1254714 | chr6_3420920_- | SINE | Alu | Name=AluSz |
| ADediting_1254715 | chr6_3420922_- | SINE | Alu | Name=AluSz |
| ADediting_1255296 | chr6_3430832_- | SINE | Alu | Name=AluSp |
| ADediting_1255614 | chr6_3436273_- | SINE | Alu | Name=AluSx1 |
| ADediting_1255615 | chr6_3436274_- | SINE | Alu | Name=AluSx1 |
| ADediting_1255616 | chr6_3436335_- | SINE | Alu | Name=AluSx1 |
| ADediting_1255617 | chr6_3436339_- | SINE | Alu | Name=AluSx1 |
| ADediting_1255618 | chr6_3436387_- | SINE | Alu | Name=AluSx1 |
| ADediting_1255628 | chr6_3436400_- | SINE | Alu | Name=AluSx1 |
| ADediting_1255629 | chr6_3436408_- | SINE | Alu | Name=AluSx1 |
| ADediting_1255630 | chr6_3436427_- | SINE | Alu | Name=AluSx1 |
| ADediting_1255670 | chr6_3437421_- | SINE | Alu | Name=AluY |
| ADediting_1255671 | chr6_3437464_- | SINE | Alu | Name=AluY |
| ADediting_1255672 | chr6_3437488_- | SINE | Alu | Name=AluY |
| ADediting_1255688 | chr6_3437567_- | SINE | Alu | Name=AluY |
| ADediting_1255689 | chr6_3437577_- | SINE | Alu | Name=AluY |
| ADediting_1255702 | chr6_3437833_- | SINE | Alu | Name=AluSq |
| ADediting_1255703 | chr6_3437886_- | SINE | Alu | Name=AluSq |
| ADediting_1255704 | chr6_3437912_- | SINE | Alu | Name=AluSq |
| ADediting_1255933 | chr6_3447793_- | SINE | Alu | Name=AluY |
| ADediting_1255934 | chr6_3447874_- | SINE | Alu | Name=AluY |
| ADediting_1255996 | chr6_3450508_- | SINE | Alu | Name=AluSg |
| ADediting_1255997 | chr6_3450572_- | SINE | Alu | Name=AluSg |
| ADediting_1255998 | chr6_3450577_- | SINE | Alu | Name=AluSg |
| ADediting_1255999 | chr6_3451263_- | SINE | Alu | Name=AluSz |
| ADediting_1256000 | chr6_3451334_- | SINE | Alu | Name=AluSz |
| ADediting_1256001 | chr6_3451335_- | SINE | Alu | Name=AluSz |
| ADediting_1256002 | chr6_3451398_- | SINE | Alu | Name=AluSz |
| ADediting_1256003 | chr6_3451400_- | SINE | Alu | Name=AluSz |
| ADediting_1256004 | chr6_3451464_- | SINE | Alu | Name=AluSz |
| ADediting_1256005 | chr6_3451469_- | SINE | Alu | Name=AluSz |
| ADediting_1256006 | chr6_3452342_- | SINE | Alu | Name=AluJr |
| ADediting_1256007 | chr6_3452375_- | SINE | Alu | Name=AluJr |
| ADediting_1256008 | chr6_3452401_- | SINE | Alu | Name=AluJr |
| ADediting_1256009 | chr6_3452408_- | SINE | Alu | Name=AluJr |
| ADediting_1256010 | chr6_3452471_- | SINE | Alu | Name=AluJr |
| ADediting_1256011 | chr6_3452477_- | SINE | Alu | Name=AluJr |
| ADediting_1256012 | chr6_3452487_- | SINE | Alu | Name=AluJr |
| ADediting_1256013 | chr6_3452547_- | SINE | Alu | Name=AluJr |
| ADediting_1256014 | chr6_3452575_- | SINE | Alu | Name=AluJr |
| ADediting_1583564 | chr6_3334282_- | SINE | Alu | Name=AluSq2 |
| ADediting_1583565 | chr6_3334286_- | SINE | Alu | Name=AluSq2 |
| ADediting_1661188 | chr6_3401275_- | SINE | Alu | Name=AluSx1 |
| ADediting_1661189 | chr6_3420963_- | SINE | Alu | Name=AluSz |
| ADediting_1661190 | chr6_3420973_- | SINE | Alu | Name=AluSz |
| ADediting_1661191 | chr6_3420979_- | SINE | Alu | Name=AluSz |
| ADediting_1661221 | chr6_3452499_- | SINE | Alu | Name=AluJr |
| ADediting_1661222 | chr6_3452523_- | SINE | Alu | Name=AluJr |
Top |
RNA A-to-I editing events in the alternative splicing sites for SLC22A23 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
Top |
Differntial gene expression between RNA A-to-I edited versus non-edited samples for SLC22A23 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for SLC22A23 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for SLC22A23 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1337757 | chr7_5495852_- | ENSG00000137266.14 | ENST00000380302.8 | SLC22A23-202 | hsa-miR-589-3p | chr6 | 3272723 | 3272729 | 7mer-m8 | 3272722 | 3272749 | 165 | -29.51 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000137266.14 | ENST00000406686.7 | SLC22A23-203 | hsa-miR-589-3p | chr6 | 3272723 | 3272729 | 7mer-m8 | 3272722 | 3272749 | 165 | -29.51 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000137266.14 | ENST00000436008.6 | SLC22A23-205 | hsa-miR-589-3p | chr6 | 3272723 | 3272729 | 7mer-m8 | 3272722 | 3272749 | 165 | -29.51 |
| ADediting_1391023 | chr8_140732605_- | ENSG00000137266.14 | ENST00000406686.7 | SLC22A23-203 | hsa-miR-151a-3p | chr6 | 3270922 | 3270928 | 7mer-m8 | 3270921 | 3270941 | 147 | -16.25 |
| ADediting_1391023 | chr8_140732605_- | ENSG00000137266.14 | ENST00000436008.6 | SLC22A23-205 | hsa-miR-151a-3p | chr6 | 3270922 | 3270928 | 7mer-m8 | 3270921 | 3270941 | 147 | -16.25 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000137266.14 | ENST00000406686.7 | SLC22A23-203 | hsa-miR-641 | chr6 | 3271425 | 3271431 | 7mer-m8 | 3271424 | 3271446 | 152 | -15.06 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000137266.14 | ENST00000436008.6 | SLC22A23-205 | hsa-miR-641 | chr6 | 3271425 | 3271431 | 7mer-m8 | 3271424 | 3271446 | 152 | -15.06 |
| ADediting_291761 | chr11_93733708_- | ENSG00000137266.14 | ENST00000380302.8 | SLC22A23-202 | hsa-miR-1304-3p | chr6 | 3272736 | 3272743 | 8mer-1a | 3272736 | 3272757 | 141 | -16.9 |
| ADediting_291761 | chr11_93733708_- | ENSG00000137266.14 | ENST00000406686.7 | SLC22A23-203 | hsa-miR-1304-3p | chr6 | 3270995 | 3271001 | 7mer-m8 | 3270994 | 3271016 | 159 | -24.77 |
| ADediting_291761 | chr11_93733708_- | ENSG00000137266.14 | ENST00000406686.7 | SLC22A23-203 | hsa-miR-1304-3p | chr6 | 3272736 | 3272743 | 8mer-1a | 3272736 | 3272757 | 141 | -16.9 |
| ADediting_291761 | chr11_93733708_- | ENSG00000137266.14 | ENST00000436008.6 | SLC22A23-205 | hsa-miR-1304-3p | chr6 | 3270995 | 3271001 | 7mer-m8 | 3270994 | 3271016 | 159 | -24.77 |
| ADediting_291761 | chr11_93733708_- | ENSG00000137266.14 | ENST00000436008.6 | SLC22A23-205 | hsa-miR-1304-3p | chr6 | 3272736 | 3272743 | 8mer-1a | 3272736 | 3272757 | 141 | -16.9 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1337757 | chr7_5495852_- | ENSG00000137266.14 | ENST00000436008.6 | SLC22A23-205 | hsa-miR-589-3p | chr6 | 3269126 | 3269132 | 7mer-m8 | 3269125 | 3269148 | 149 | -14.28 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000137266.14 | ENST00000406686.7 | SLC22A23-203 | hsa-miR-641 | chr6 | 3271593 | 3271599 | 7mer-m8 | 3271592 | 3271614 | 147 | -12.26 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000137266.14 | ENST00000436008.6 | SLC22A23-205 | hsa-miR-641 | chr6 | 3269440 | 3269446 | 7mer-m8 | 3269439 | 3269464 | 146 | -13.48 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000137266.14 | ENST00000436008.6 | SLC22A23-205 | hsa-miR-641 | chr6 | 3271593 | 3271599 | 7mer-m8 | 3271592 | 3271614 | 147 | -12.26 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000137266.14 | ENST00000406686.7 | SLC22A23-203 | hsa-miR-641 | chr6 | 3271593 | 3271599 | 7mer-m8 | 3271592 | 3271614 | 147 | -12.26 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000137266.14 | ENST00000436008.6 | SLC22A23-205 | hsa-miR-641 | chr6 | 3269440 | 3269446 | 7mer-m8 | 3269439 | 3269464 | 146 | -13.48 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000137266.14 | ENST00000436008.6 | SLC22A23-205 | hsa-miR-641 | chr6 | 3271593 | 3271599 | 7mer-m8 | 3271592 | 3271614 | 147 | -12.26 |
| ADediting_291761 | chr11_93733708_- | ENSG00000137266.14 | ENST00000485307.5 | SLC22A23-209 | hsa-miR-1304-3p | chr6 | 3283667 | 3283674 | 8mer-1a | 3283667 | 3283688 | 144 | -20.35 |
| ADediting_527135 | chr16_24203190_+ | ENSG00000137266.14 | ENST00000406686.7 | SLC22A23-203 | hsa-miR-1273h-3p | chr6 | 3269536 | 3269542 | 7mer-m8 | 3269535 | 3269557 | 150 | -16.57 |
| ADediting_527135 | chr16_24203190_+ | ENSG00000137266.14 | ENST00000436008.6 | SLC22A23-205 | hsa-miR-1273h-3p | chr6 | 3269536 | 3269542 | 7mer-m8 | 3269535 | 3269557 | 150 | -16.57 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000137266.14 | ENST00000406686.7 | SLC22A23-203 | hsa-miR-4775 | chr6 | 3270031 | 3270037 | 7mer-m8 | 3270030 | 3270053 | 143 | -2.91 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000137266.14 | ENST00000436008.6 | SLC22A23-205 | hsa-miR-4775 | chr6 | 3269160 | 3269167 | 8mer-1a | 3269160 | 3269180 | 147 | -11.28 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000137266.14 | ENST00000436008.6 | SLC22A23-205 | hsa-miR-4775 | chr6 | 3270031 | 3270037 | 7mer-m8 | 3270030 | 3270053 | 143 | -2.91 |
| Differentially expressed gene-miRNA network |
Top |
The effects of the RNA editing to the stability of the RNA structures for SLC22A23 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for SLC22A23 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| CER | ADediting_1254522 | chr6_3313848_- | 0.000274942897117271 | 0.292935270369588 | 1.26625115948283e-08 | 0.443961301520007 | 3.8196485455595e-06 | 0.367111988849309 |
| CER | ADediting_1254523 | chr6_3313929_- | 0.000575064560070549 | 0.277895212774571 | 1.6832427550101e-06 | 0.379406303004185 | 0.141682101401741 | 0.120559160968037 |
| CER | ADediting_1254524 | chr6_3313943_- | 0.00545616836459051 | 0.22583767677261 | 2.17601807725795e-07 | 0.408082956197643 | 0.0223217668649176 | 0.186477486923495 |
| TCX | ADediting_1254524 | chr6_3313943_- | 0.00668349915597748 | 0.22056256959756 | 0.7115324544916 | 0.0304415988624416 | 8.24887501062437e-05 | 0.315833388954462 |
| CER | ADediting_1254525 | chr6_3313966_- | 0.00479462671915252 | 0.229138895267364 | 5.61090209747034e-05 | 0.322785503575712 | 0.00230111378754732 | 0.247091581787151 |
| CER | ADediting_1254526 | chr6_3313969_- | 0.00177720066315629 | 0.253115674066246 | 8.36265713787706e-07 | 0.38951893564939 | 0.00139880238455219 | 0.258574354953257 |
| TCX | ADediting_1254526 | chr6_3313969_- | 0.150283615912957 | 0.118031921370308 | 0.718955120560582 | -0.0296234504409397 | 2.82147462425145e-07 | 0.404587754424267 |
| CER | ADediting_1254528 | chr6_3313985_- | 0.0025136976698028 | 0.244997909948028 | 5.72613703894204e-06 | 0.360845711729338 | 0.00116675487554096 | 0.262634403173002 |
| CER | ADediting_1254529 | chr6_3313990_- | 0.00121669703566917 | 0.261701880947968 | 3.80643776813259e-07 | 0.400508634947809 | 0.0177131561226126 | 0.193422857520335 |
| CER | ADediting_1254530 | chr6_3313996_- | 0.000893214210920531 | 0.268501245310838 | 8.54021873138649e-08 | 0.420348179071349 | 0.000308530516405214 | 0.290640343078381 |
| TCX | ADediting_1254530 | chr6_3313996_- | 0.0179572885678499 | 0.193017752413647 | 0.369069566696023 | 0.0738567773112061 | 2.97881408457098e-06 | 0.370895846372852 |
| CER | ADediting_1254532 | chr6_3315675_- | 0.00366589681358336 | 0.235855174790307 | 1.34027767539346e-05 | 0.347236273521463 | 0.275851258951266 | 0.0895427378861925 |
| CER | ADediting_1254533 | chr6_3315700_- | 0.000226126145437781 | 0.296783960229986 | 3.92913568098355e-08 | 0.430171146243858 | 0.0388359152874184 | 0.16888095888782 |
| TCX | ADediting_1254533 | chr6_3315700_- | 0.0192010428925974 | 0.191025138120794 | 0.838776065049717 | -0.0167513483989806 | 5.51281989702975e-08 | 0.425924659501502 |
| CER | ADediting_1254534 | chr6_3315716_- | 0.0106048465387518 | 0.208103544115843 | 2.84140321110022e-05 | 0.334662360964793 | 0.0224296575453484 | 0.186330315853751 |
| CER | ADediting_1254535 | chr6_3315831_- | 0.000712124066666187 | 0.273376337510722 | 1.25568953412576e-06 | 0.383683742600958 | 0.00603317755087342 | 0.223238542812676 |
| TCX | ADediting_1254535 | chr6_3315831_- | 0.960828599167396 | -0.00404393882779432 | 0.0659606263561706 | -0.150531134509244 | 3.53963808413655e-07 | 0.40150360173002 |
| CER | ADediting_1254537 | chr6_3316698_- | 0.00042693030838068 | 0.284067131520593 | 1.57798327953589e-09 | 0.46782573484872 | 0.00111395691449765 | 0.263660822809642 |
| CER | ADediting_1254538 | chr6_3316709_- | 0.000339033783199839 | 0.288748672390361 | 1.05439328317197e-07 | 0.417626629372038 | 0.0227275228844329 | 0.185927144067901 |
| CER | ADediting_1254539 | chr6_3316714_- | 0.000288807017994111 | 0.291958081463193 | 6.46034636480113e-10 | 0.477523552038498 | 0.000577660896336603 | 0.277800773499656 |
| CER | ADediting_1254541 | chr6_3316740_- | 0.00131670563966887 | 0.259935234538347 | 4.56909877960927e-09 | 0.455871461626683 | 0.00170790004814603 | 0.254030592174085 |
| TCX | ADediting_1254541 | chr6_3316740_- | 0.0365726502262714 | 0.170860947261953 | 0.648897411792961 | 0.0374750700472815 | 9.25353192096064e-07 | 0.388076265213749 |
| CER | ADediting_1254543 | chr6_3316762_- | 0.000110900940232587 | 0.31037553217338 | 1.57262671744018e-11 | 0.514899250440665 | 0.00661969428004017 | 0.220814600148669 |
| CER | ADediting_1254544 | chr6_3316766_- | 0.000415796378752881 | 0.284607910464425 | 3.43509163481613e-08 | 0.431840084537592 | 0.0080714281286046 | 0.21554989069973 |
| CER | ADediting_1254545 | chr6_3316785_- | 0.0175588556368545 | 0.193681403427649 | 0.000109768306248914 | 0.310566612461474 | 0.000105136909661022 | 0.311367607694987 |
| CER | ADediting_1254551 | chr6_3316826_- | 0.000292165825445933 | 0.291727896161547 | 2.13234366969943e-08 | 0.437690606110027 | 3.26046821237253e-06 | 0.369526437606949 |
| CER | ADediting_1254555 | chr6_3316851_- | 0.000568538225542724 | 0.278134348698358 | 4.92282308633777e-08 | 0.42735052432583 | 0.0035952644527403 | 0.236334913209925 |
| CER | ADediting_1254557 | chr6_3316857_- | 6.00035057571897e-05 | 0.321587034227843 | 2.42146992750656e-08 | 0.436141234440272 | 8.16472294115547e-05 | 0.316020597533285 |
| CER | ADediting_1254559 | chr6_3320490_- | 0.0238365509831 | 0.184464904896349 | 7.37578853899517e-06 | 0.356859412659204 | 0.000371544729228578 | 0.286898693870055 |
| CER | ADediting_1254575 | chr6_3322025_- | 0.000711173886568118 | 0.273404801413572 | 3.03049375101151e-09 | 0.46054280711446 | 0.0212444181253121 | 0.187981678495871 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 1.82937307947093e-64 | 0.779248628744687 | 5.01800690562724e-67 | 0.788643929005034 | 0.000118671397295435 | 0.216869158957013 |
| AC | 1.01011243278926e-47 | 0.756928992996689 | 3.16758211900169e-40 | 0.713713588662573 | 1.60407783609228e-32 | 0.659003377734561 |
| PCC | 8.37220956778067e-30 | 0.703142174603314 | 4.42386571971895e-33 | 0.730087450801281 | 1.33506875305338e-08 | 0.396709728215 |
| CER | 1.26124823929886e-17 | 0.624946709259858 | 5.55424954179348e-27 | 0.737225186876947 | 3.07153923478495e-12 | 0.529994341575062 |
| TCX | 8.08451714728064e-15 | 0.579305461502857 | 0.25557663095502 | 0.0934064555477113 | 1.24329255846596e-25 | 0.723900399408568 |
| FP | 9.94881879295773e-18 | 0.584998205719187 | 6.84223784783262e-09 | 0.417295596608569 | 1.07446422146388e-22 | 0.649396689386514 |
| IFG | 0.0020774646405804 | 0.586122986593253 | 0.00485772365928241 | 0.544850524108284 | 0.000441500038317512 | 0.649580582533219 |
| PG | 2.07220991177103e-10 | 0.444512502991069 | 9.77409517879153e-07 | 0.349944287830975 | 1.64617903365561e-13 | 0.506444615749546 |
| STG | 0.00021154240366647 | 0.393675617517571 | 0.138082145187317 | 0.163163744688087 | 0.000194003550111419 | 0.395808658849215 |
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Relation with AD stages for SLC22A23 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| CER | ADediting_1254537 | chr6_3316698_- | 0.00121462413810603 | 0.307334015449647 |
| CER | ADediting_1254539 | chr6_3316714_- | 0.000993735399815085 | 0.312465632794151 |
| CER | ADediting_1254541 | chr6_3316740_- | 0.000638018021025028 | 0.323483105986832 |
| CER | ADediting_1254551 | chr6_3316826_- | 0.00109528392875584 | 0.309989473103382 |
| TCX | ADediting_1254526 | chr6_3313969_- | 0.0012302820143801 | 0.309809436218299 |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 5.12774072469063e-09 | 0.525767558108864 |
| TCX | 2.3778534856435e-12 | 0.614773912272986 |
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RelatedDrugs for SLC22A23 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SLC22A23 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| SLC22A23 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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