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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for RPE |
 Gene summary |
| Gene information | Gene symbol | RPE | Gene ID | 6120 |
| Gene name | ribulose-5-phosphate-3-epimerase | |
| Synonyms | RPE2-1 | |
| Cytomap | 2q34 | |
| Type of gene | protein-coding | |
| Description | ribulose-phosphate 3-epimerase | |
| Modification date | 20200313 | |
| UniProtAcc | Q96AT9, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| RPE | GO:0005975 | carbohydrate metabolic process | 20923965 |
| RPE | GO:0006098 | pentose-phosphate shunt | 20923965 |
Top |
RNA A-to-I events for RPE |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_844382(210003039, +), ADediting_844383(210003094, +), ADediting_844384(210003098, +), ADediting_844385(210003201, +), ADediting_844386(210003241, +), ADediting_844387(210008373, +), ADediting_844388(210008375, +), ADediting_844389(210008393, +), ADediting_844390(210008396, +), ADediting_844391(210008435, +), ADediting_844392(210008468, +), ADediting_844393(210008476, +), ADediting_844394(210008747, +), ADediting_844395(210010447, +), ADediting_844396(210010478, +), ADediting_844397(210010484, +), ADediting_844398(210010502, +), ADediting_844399(210010532, +), ADediting_844400(210010731, +), ADediting_844401(210010732, +), ADediting_844402(210010742, +), ADediting_844403(210010775, +), ADediting_844404(210010787, +), ADediting_844405(210010788, +), ADediting_844406(210010789, +), ADediting_844407(210010791, +), ADediting_844408(210010797, +), ADediting_844409(210010798, +), ADediting_844410(210010803, +), ADediting_844411(210010811, +), ADediting_844412(210010820, +), ADediting_844413(210010833, +), ADediting_844414(210010839, +), ADediting_844415(210010859, +), ADediting_844416(210010868, +), ADediting_844417(210010873, +), ADediting_844418(210011720, +), ADediting_844419(210011725, +), ADediting_844420(210011775, +), ADediting_844421(210011799, +), ADediting_844422(210012342, +), ADediting_844423(210013358, +), ADediting_844424(210013546, +), ADediting_844425(210013547, +), ADediting_844426(210013757, +), ADediting_844427(210014166, +), ADediting_844428(210014172, +), ADediting_844429(210014218, +), ADediting_844430(210014271, +), ADediting_844431(210014296, +), ADediting_844432(210014349, +), ADediting_844433(210014363, +), ADediting_844434(210014365, +), ADediting_844435(210014372, +), ADediting_844436(210014529, +), ADediting_844437(210014531, +), ADediting_844438(210014535, +), ADediting_844439(210014537, +), ADediting_844440(210014555, +), ADediting_844441(210014565, +), ADediting_844442(210014567, +), ADediting_844443(210014573, +), ADediting_844444(210014583, +), ADediting_844445(210014586, +), ADediting_844446(210014597, +), ADediting_844447(210014609, +), ADediting_844450(210016977, +), ADediting_1635732(210010768, +), |
Top |
RNA editing positional annotations for RPE using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_844382 | chr2_210003039_+ | intronic |
| ADediting_844383 | chr2_210003094_+ | intronic |
| ADediting_844384 | chr2_210003098_+ | intronic |
| ADediting_844385 | chr2_210003201_+ | intronic |
| ADediting_844386 | chr2_210003241_+ | intronic |
| ADediting_844387 | chr2_210008373_+ | intronic |
| ADediting_844388 | chr2_210008375_+ | intronic |
| ADediting_844389 | chr2_210008393_+ | intronic |
| ADediting_844390 | chr2_210008396_+ | intronic |
| ADediting_844391 | chr2_210008435_+ | intronic |
| ADediting_844392 | chr2_210008468_+ | intronic |
| ADediting_844393 | chr2_210008476_+ | intronic |
| ADediting_844394 | chr2_210008747_+ | intronic |
| ADediting_844395 | chr2_210010447_+ | intronic |
| ADediting_844396 | chr2_210010478_+ | intronic |
| ADediting_844397 | chr2_210010484_+ | intronic |
| ADediting_844398 | chr2_210010502_+ | intronic |
| ADediting_844399 | chr2_210010532_+ | intronic |
| ADediting_844400 | chr2_210010731_+ | intronic |
| ADediting_844401 | chr2_210010732_+ | intronic |
| ADediting_844402 | chr2_210010742_+ | intronic |
| ADediting_844403 | chr2_210010775_+ | intronic |
| ADediting_844404 | chr2_210010787_+ | intronic |
| ADediting_844405 | chr2_210010788_+ | intronic |
| ADediting_844406 | chr2_210010789_+ | intronic |
| ADediting_844407 | chr2_210010791_+ | intronic |
| ADediting_844408 | chr2_210010797_+ | intronic |
| ADediting_844409 | chr2_210010798_+ | intronic |
| ADediting_844410 | chr2_210010803_+ | intronic |
| ADediting_844411 | chr2_210010811_+ | intronic |
| ADediting_844412 | chr2_210010820_+ | intronic |
| ADediting_844413 | chr2_210010833_+ | intronic |
| ADediting_844414 | chr2_210010839_+ | intronic |
| ADediting_844415 | chr2_210010859_+ | intronic |
| ADediting_844416 | chr2_210010868_+ | intronic |
| ADediting_844417 | chr2_210010873_+ | intronic |
| ADediting_844418 | chr2_210011720_+ | intronic |
| ADediting_844419 | chr2_210011725_+ | intronic |
| ADediting_844420 | chr2_210011775_+ | intronic |
| ADediting_844421 | chr2_210011799_+ | intronic |
| ADediting_844422 | chr2_210012342_+ | intronic |
| ADediting_844423 | chr2_210013358_+ | intronic |
| ADediting_844424 | chr2_210013546_+ | intronic |
| ADediting_844425 | chr2_210013547_+ | intronic |
| ADediting_844426 | chr2_210013757_+ | intronic |
| ADediting_844427 | chr2_210014166_+ | intronic |
| ADediting_844428 | chr2_210014172_+ | intronic |
| ADediting_844429 | chr2_210014218_+ | intronic |
| ADediting_844430 | chr2_210014271_+ | intronic |
| ADediting_844431 | chr2_210014296_+ | intronic |
| ADediting_844432 | chr2_210014349_+ | intronic |
| ADediting_844433 | chr2_210014363_+ | intronic |
| ADediting_844434 | chr2_210014365_+ | intronic |
| ADediting_844435 | chr2_210014372_+ | intronic |
| ADediting_844436 | chr2_210014529_+ | intronic |
| ADediting_844437 | chr2_210014531_+ | intronic |
| ADediting_844438 | chr2_210014535_+ | intronic |
| ADediting_844439 | chr2_210014537_+ | intronic |
| ADediting_844440 | chr2_210014555_+ | intronic |
| ADediting_844441 | chr2_210014565_+ | intronic |
| ADediting_844442 | chr2_210014567_+ | intronic |
| ADediting_844443 | chr2_210014573_+ | intronic |
| ADediting_844444 | chr2_210014583_+ | intronic |
| ADediting_844445 | chr2_210014586_+ | intronic |
| ADediting_844446 | chr2_210014597_+ | intronic |
| ADediting_844447 | chr2_210014609_+ | intronic |
| ADediting_844450 | chr2_210016977_+ | intronic |
| ADediting_1635732 | chr2_210010768_+ | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_844383 | chr2_210003094_+ | SINE | MIR | Name=MIR3 |
| ADediting_844384 | chr2_210003098_+ | SINE | MIR | Name=MIR3 |
| ADediting_844385 | chr2_210003201_+ | SINE | MIR | Name=MIR |
| ADediting_844386 | chr2_210003241_+ | SINE | MIR | Name=MIR |
| ADediting_844387 | chr2_210008373_+ | SINE | Alu | Name=AluSg |
| ADediting_844388 | chr2_210008375_+ | SINE | Alu | Name=AluSg |
| ADediting_844389 | chr2_210008393_+ | SINE | Alu | Name=AluSg |
| ADediting_844390 | chr2_210008396_+ | SINE | Alu | Name=AluSg |
| ADediting_844391 | chr2_210008435_+ | SINE | Alu | Name=AluSg |
| ADediting_844392 | chr2_210008468_+ | SINE | Alu | Name=AluSg |
| ADediting_844393 | chr2_210008476_+ | SINE | Alu | Name=AluSg |
| ADediting_844394 | chr2_210008747_+ | SINE | Alu | Name=AluSz |
| ADediting_844395 | chr2_210010447_+ | SINE | Alu | Name=FLAM_C |
| ADediting_844396 | chr2_210010478_+ | SINE | Alu | Name=FLAM_C |
| ADediting_844397 | chr2_210010484_+ | SINE | Alu | Name=FLAM_C |
| ADediting_844398 | chr2_210010502_+ | SINE | Alu | Name=FLAM_C |
| ADediting_844399 | chr2_210010532_+ | SINE | Alu | Name=FLAM_C |
| ADediting_844400 | chr2_210010731_+ | SINE | Alu | Name=AluSx1 |
| ADediting_844401 | chr2_210010732_+ | SINE | Alu | Name=AluSx1 |
| ADediting_844402 | chr2_210010742_+ | SINE | Alu | Name=AluSx1 |
| ADediting_844403 | chr2_210010775_+ | SINE | Alu | Name=AluSx1 |
| ADediting_844404 | chr2_210010787_+ | SINE | Alu | Name=AluSx1 |
| ADediting_844405 | chr2_210010788_+ | SINE | Alu | Name=AluSx1 |
| ADediting_844406 | chr2_210010789_+ | SINE | Alu | Name=AluSx1 |
| ADediting_844407 | chr2_210010791_+ | SINE | Alu | Name=AluSx1 |
| ADediting_844408 | chr2_210010797_+ | SINE | Alu | Name=AluSx1 |
| ADediting_844409 | chr2_210010798_+ | SINE | Alu | Name=AluSx1 |
| ADediting_844410 | chr2_210010803_+ | SINE | Alu | Name=AluSx1 |
| ADediting_844411 | chr2_210010811_+ | SINE | Alu | Name=AluSx1 |
| ADediting_844412 | chr2_210010820_+ | SINE | Alu | Name=AluSx1 |
| ADediting_844413 | chr2_210010833_+ | SINE | Alu | Name=AluSx1 |
| ADediting_844414 | chr2_210010839_+ | SINE | Alu | Name=AluSx1 |
| ADediting_844415 | chr2_210010859_+ | SINE | Alu | Name=AluSx1 |
| ADediting_844416 | chr2_210010868_+ | SINE | Alu | Name=AluSx1 |
| ADediting_844417 | chr2_210010873_+ | SINE | Alu | Name=AluSx1 |
| ADediting_844418 | chr2_210011720_+ | SINE | Alu | Name=AluJo |
| ADediting_844419 | chr2_210011725_+ | SINE | Alu | Name=AluJo |
| ADediting_844420 | chr2_210011775_+ | SINE | Alu | Name=AluJo |
| ADediting_844421 | chr2_210011799_+ | SINE | Alu | Name=AluJo |
| ADediting_844422 | chr2_210012342_+ | DNA | hAT-Charlie | Name=Charlie1a |
| ADediting_844423 | chr2_210013358_+ | SINE | Alu | Name=AluJo |
| ADediting_844424 | chr2_210013546_+ | SINE | Alu | Name=AluJo |
| ADediting_844425 | chr2_210013547_+ | SINE | Alu | Name=AluJo |
| ADediting_844426 | chr2_210013757_+ | SINE | Alu | Name=FLAM_C |
| ADediting_844427 | chr2_210014166_+ | SINE | Alu | Name=AluY |
| ADediting_844428 | chr2_210014172_+ | SINE | Alu | Name=AluY |
| ADediting_844429 | chr2_210014218_+ | SINE | Alu | Name=AluY |
| ADediting_844430 | chr2_210014271_+ | SINE | Alu | Name=AluY |
| ADediting_844431 | chr2_210014296_+ | SINE | Alu | Name=AluY |
| ADediting_844432 | chr2_210014349_+ | SINE | Alu | Name=AluY |
| ADediting_844433 | chr2_210014363_+ | SINE | Alu | Name=AluY |
| ADediting_844434 | chr2_210014365_+ | SINE | Alu | Name=AluY |
| ADediting_844435 | chr2_210014372_+ | SINE | Alu | Name=AluY |
| ADediting_844436 | chr2_210014529_+ | SINE | Alu | Name=FLAM_C |
| ADediting_844437 | chr2_210014531_+ | SINE | Alu | Name=FLAM_C |
| ADediting_844438 | chr2_210014535_+ | SINE | Alu | Name=FLAM_C |
| ADediting_844439 | chr2_210014537_+ | SINE | Alu | Name=FLAM_C |
| ADediting_844440 | chr2_210014555_+ | SINE | Alu | Name=FLAM_C |
| ADediting_844441 | chr2_210014565_+ | SINE | Alu | Name=FLAM_C |
| ADediting_844442 | chr2_210014567_+ | SINE | Alu | Name=FLAM_C |
| ADediting_844443 | chr2_210014573_+ | SINE | Alu | Name=FLAM_C |
| ADediting_844444 | chr2_210014583_+ | SINE | Alu | Name=FLAM_C |
| ADediting_844445 | chr2_210014586_+ | SINE | Alu | Name=FLAM_C |
| ADediting_844446 | chr2_210014597_+ | SINE | Alu | Name=FLAM_C |
| ADediting_844447 | chr2_210014609_+ | SINE | Alu | Name=FLAM_C |
| ADediting_844450 | chr2_210016977_+ | SINE | Alu | Name=AluJo |
| ADediting_1635732 | chr2_210010768_+ | SINE | Alu | Name=AluSx1 |
Top |
RNA A-to-I editing events in the alternative splicing sites for RPE |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| ES | ADediting_844447 | chr2_210014609_+ | 210014607:210014615 | 5ss | 1e | ACAGTGAGA | 3.45 | ACGGTGAGA | 8.94 |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
Top |
Differntial gene expression between RNA A-to-I edited versus non-edited samples for RPE |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
Top |
Protein coding region RNA A-to-I editings for RPE |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
Top |
The effects of the RNA editing to the miRNA binding sites for RPE |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000197713.15 | ENST00000354506.10 | RPE-201 | hsa-miR-5688 | chr2 | 210021513 | 210021519 | 7mer-m8 | 210021499 | 210021520 | 146 | -15.98 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000197713.15 | ENST00000354506.10 | RPE-201 | hsa-miR-5688 | chr2 | 210021576 | 210021583 | 8mer-1a | 210021562 | 210021583 | 142 | -13.28 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000197713.15 | ENST00000359429.11 | RPE-202 | hsa-miR-5688 | chr2 | 210021513 | 210021519 | 7mer-m8 | 210021499 | 210021520 | 146 | -15.98 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000197713.15 | ENST00000359429.11 | RPE-202 | hsa-miR-5688 | chr2 | 210021576 | 210021583 | 8mer-1a | 210021562 | 210021583 | 142 | -13.28 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000197713.15 | ENST00000429921.5 | RPE-206 | hsa-miR-5688 | chr2 | 210021513 | 210021519 | 7mer-m8 | 210021499 | 210021520 | 146 | -15.98 |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000197713.15 | ENST00000354506.10 | RPE-201 | hsa-miR-4477b | chr2 | 210021756 | 210021762 | 7mer-m8 | 210021741 | 210021763 | 163 | -17.64 |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000197713.15 | ENST00000359429.11 | RPE-202 | hsa-miR-4477b | chr2 | 210021756 | 210021762 | 7mer-m8 | 210021741 | 210021763 | 163 | -17.64 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000197713.15 | ENST00000354506.10 | RPE-201 | hsa-miR-5688 | chr2 | 210021341 | 210021347 | 7mer-1a | 210021336 | 210021357 | 153 | -10.33 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000197713.15 | ENST00000354506.10 | RPE-201 | hsa-miR-5688 | chr2 | 210021350 | 210021356 | 7mer-m8 | 210021336 | 210021357 | 153 | -10.33 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000197713.15 | ENST00000359429.11 | RPE-202 | hsa-miR-5688 | chr2 | 210021341 | 210021347 | 7mer-1a | 210021336 | 210021357 | 153 | -10.33 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000197713.15 | ENST00000359429.11 | RPE-202 | hsa-miR-5688 | chr2 | 210021350 | 210021356 | 7mer-m8 | 210021336 | 210021357 | 153 | -10.33 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000197713.15 | ENST00000429921.5 | RPE-206 | hsa-miR-5688 | chr2 | 210021341 | 210021347 | 7mer-1a | 210021336 | 210021357 | 153 | -10.33 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000197713.15 | ENST00000429921.5 | RPE-206 | hsa-miR-5688 | chr2 | 210021350 | 210021356 | 7mer-m8 | 210021336 | 210021357 | 153 | -10.33 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000197713.15 | ENST00000354506.10 | RPE-201 | hsa-miR-589-3p | chr2 | 210021119 | 210021126 | 8mer-1a | 210021103 | 210021126 | 141 | -11.54 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000197713.15 | ENST00000359429.11 | RPE-202 | hsa-miR-589-3p | chr2 | 210021119 | 210021126 | 8mer-1a | 210021103 | 210021126 | 141 | -11.54 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000197713.15 | ENST00000429921.5 | RPE-206 | hsa-miR-589-3p | chr2 | 210021119 | 210021126 | 8mer-1a | 210021103 | 210021126 | 141 | -11.54 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000197713.15 | ENST00000454822.5 | RPE-216 | hsa-miR-589-3p | chr2 | 210021119 | 210021126 | 8mer-1a | 210021103 | 210021126 | 141 | -11.54 |
| ADediting_1391023 | chr8_140732605_- | ENSG00000197713.15 | ENST00000354506.10 | RPE-201 | hsa-miR-151a-3p | chr2 | 210020963 | 210020970 | 8mer-1a | 210020950 | 210020970 | 145 | -11.26 |
| ADediting_1391023 | chr8_140732605_- | ENSG00000197713.15 | ENST00000359429.11 | RPE-202 | hsa-miR-151a-3p | chr2 | 210020963 | 210020970 | 8mer-1a | 210020950 | 210020970 | 145 | -11.26 |
| ADediting_1391023 | chr8_140732605_- | ENSG00000197713.15 | ENST00000429921.5 | RPE-206 | hsa-miR-151a-3p | chr2 | 210020963 | 210020970 | 8mer-1a | 210020950 | 210020970 | 145 | -11.26 |
| ADediting_1391023 | chr8_140732605_- | ENSG00000197713.15 | ENST00000454822.5 | RPE-216 | hsa-miR-151a-3p | chr2 | 210020963 | 210020970 | 8mer-1a | 210020950 | 210020970 | 145 | -11.26 |
| ADediting_1596844 | chr1_162342605_+ | ENSG00000197713.15 | ENST00000354506.10 | RPE-201 | hsa-miR-556-3p | chr2 | 210020487 | 210020493 | 7mer-m8 | 210020473 | 210020494 | 145 | -9.9 |
| ADediting_1596844 | chr1_162342605_+ | ENSG00000197713.15 | ENST00000359429.11 | RPE-202 | hsa-miR-556-3p | chr2 | 210020487 | 210020493 | 7mer-m8 | 210020473 | 210020494 | 145 | -9.9 |
| ADediting_1596844 | chr1_162342605_+ | ENSG00000197713.15 | ENST00000429921.5 | RPE-206 | hsa-miR-556-3p | chr2 | 210020487 | 210020493 | 7mer-m8 | 210020473 | 210020494 | 145 | -9.9 |
| ADediting_1596844 | chr1_162342605_+ | ENSG00000197713.15 | ENST00000454822.5 | RPE-216 | hsa-miR-556-3p | chr2 | 210020487 | 210020493 | 7mer-m8 | 210020473 | 210020494 | 145 | -9.9 |
| ADediting_286380 | chr11_79422188_- | ENSG00000197713.15 | ENST00000354506.10 | RPE-201 | hsa-miR-5579-3p | chr2 | 210021914 | 210021920 | 7mer-m8 | 210021900 | 210021921 | 140 | -9.37 |
| ADediting_286380 | chr11_79422188_- | ENSG00000197713.15 | ENST00000359429.11 | RPE-202 | hsa-miR-5579-3p | chr2 | 210021914 | 210021920 | 7mer-m8 | 210021900 | 210021921 | 140 | -9.37 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000197713.15 | ENST00000354506.10 | RPE-201 | hsa-miR-4775 | chr2 | 210020827 | 210020833 | 7mer-1a | 210020811 | 210020833 | 141 | -6.62 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000197713.15 | ENST00000359429.11 | RPE-202 | hsa-miR-4775 | chr2 | 210020827 | 210020833 | 7mer-1a | 210020811 | 210020833 | 141 | -6.62 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000197713.15 | ENST00000429921.5 | RPE-206 | hsa-miR-4775 | chr2 | 210020827 | 210020833 | 7mer-1a | 210020811 | 210020833 | 141 | -6.62 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000197713.15 | ENST00000454822.5 | RPE-216 | hsa-miR-4775 | chr2 | 210020827 | 210020833 | 7mer-1a | 210020811 | 210020833 | 141 | -6.62 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for RPE |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for RPE |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| STG | ADediting_844437 | chr2_210014531_+ | 0.0466641112570501 | 0.217705481649407 | 0.00390466588181627 | 0.311650340385663 | 0.547405724696165 | -0.0665702251410723 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 5.40421514969478e-65 | 0.781229653679855 | 3.24096084470241e-38 | 0.647413864168199 | 0.424576501768371 | 0.045512487081958 |
| AC | 1.42528128500685e-102 | 0.919531990853752 | 1.08191822243507e-56 | 0.798944366427808 | 2.57745617726411e-07 | 0.318891466274414 |
| PCC | 5.78344065389878e-52 | 0.839532067652936 | 1.97113989868742e-52 | 0.84151654681364 | 0.0923653452887338 | 0.122126644338729 |
| CER | 3.57675094785911e-43 | 0.850674812691672 | 1.09013450671383e-21 | 0.679960540070163 | 0.0144966886431466 | 0.199270939208162 |
| TCX | 1.5453234419185e-51 | 0.887049555424001 | 2.63799381715981e-12 | 0.53136352559242 | 0.000361127786280983 | 0.287474563889231 |
| FP | 2.82702691993768e-25 | 0.677649572074374 | 3.75251049837473e-29 | 0.714904141114625 | 0.308420306096628 | 0.0767711131352332 |
| IFG | 6.0211279974457e-06 | 0.772587684240461 | 7.74815732292404e-05 | 0.707094660411684 | 0.250336513547028 | 0.238786490552066 |
| PG | 9.85388901736787e-64 | 0.887243074276116 | 1.732858057274e-32 | 0.731987944042403 | 0.832154091203331 | -0.0156446860076057 |
| STG | 3.41400197979761e-23 | 0.837136910184829 | 3.99951643223789e-18 | 0.776510977545578 | 0.89461241123272 | 0.0146727602717567 |
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Relation with AD stages for RPE |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| IFG | ADediting_844437 | chr2_210014531_+ | 0.0354713369979928 | 0.422303326441651 |
| IFG | ADediting_844438 | chr2_210014535_+ | 0.0112614191895443 | 0.498187153213234 |
| IFG | ADediting_844439 | chr2_210014537_+ | 0.0354713369979928 | 0.422303326441651 |
| PG | ADediting_844438 | chr2_210014535_+ | 3.1317552194576e-05 | -0.300245229504873 |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 0.000254995890811135 | 0.345055894165086 |
| TCX | 0.000102155434197229 | 0.368390963011202 |
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RelatedDrugs for RPE |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RPE |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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