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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for FAM3A |
 Gene summary |
| Gene information | Gene symbol | FAM3A | Gene ID | 60343 |
| Gene name | FAM3 metabolism regulating signaling molecule A | |
| Synonyms | 2.19|DLD|DXS560S|XAP-7 | |
| Cytomap | Xq28 | |
| Type of gene | protein-coding | |
| Description | protein FAM3Acytokine-like protein 2-19family with sequence similarity 3 member A | |
| Modification date | 20200313 | |
| UniProtAcc | P98173, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| FAM3A | GO:0019732 | antifungal humoral response | 18212107 |
| FAM3A | GO:0061844 | antimicrobial humoral immune response mediated by antimicrobial peptide | 18212107 |
| FAM3A | GO:1905035 | negative regulation of antifungal innate immune response | 18212107 |
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RNA A-to-I events for FAM3A |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_1494652(154512317, -), ADediting_1494653(154512382, -), ADediting_1494654(154512401, -), ADediting_1494655(154513375, -), ADediting_1494656(154513387, -), ADediting_1494657(154513413, -), ADediting_1494658(154513508, -), ADediting_1494659(154513518, -), ADediting_1494660(154513578, -), ADediting_1494661(154513586, -), ADediting_1494662(154513592, -), ADediting_1494663(154513615, -), ADediting_1494664(154514316, -), ADediting_1494665(154514471, -), ADediting_1494666(154514472, -), ADediting_1494667(154514532, -), ADediting_1494668(154514536, -), ADediting_1494669(154514542, -), ADediting_1494670(154514821, -), |
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RNA editing positional annotations for FAM3A using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| ADediting_1494652 | chrX_154512317_- | nonsynonymous SNV | ENST00000322269.10 | c.A166G | p.T56A | . | 0.001 | . |
| ADediting_1494653 | chrX_154512382_- | nonsynonymous SNV | ENST00000322269.10 | c.A101G | p.H34R | . | 0.0 | . |
| ADediting_1494653 | chrX_154512382_- | nonsynonymous SNV | ENST00000621967.4 | c.A157G | p.T53A | . | 0.0 | . |
| ADediting_1494653 | chrX_154512382_- | nonsynonymous SNV | ENST00000421517.5 | c.A157G | p.T53A | . | 0.0 | . |
| ADediting_1494653 | chrX_154512382_- | nonsynonymous SNV | ENST00000449971.5 | c.A157G | p.T53A | . | 0.0 | . |
| ADediting_1494653 | chrX_154512382_- | nonsynonymous SNV | ENST00000434658.6 | c.A157G | p.T53A | . | 0.0 | . |
| ADediting_1494654 | chrX_154512401_- | nonsynonymous SNV | ENST00000433619.2 | c.A158G | p.Q53R | . | 0.0 | . |
| ADediting_1494654 | chrX_154512401_- | nonsynonymous SNV | ENST00000322269.10 | c.A82G | p.S28G | . | 0.0 | . |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_1494652 | chrX_154512317_- | exonic |
| ADediting_1494653 | chrX_154512382_- | exonic |
| ADediting_1494654 | chrX_154512401_- | exonic |
| ADediting_1494655 | chrX_154513375_- | intronic |
| ADediting_1494656 | chrX_154513387_- | intronic |
| ADediting_1494657 | chrX_154513413_- | intronic |
| ADediting_1494658 | chrX_154513508_- | intronic |
| ADediting_1494659 | chrX_154513518_- | intronic |
| ADediting_1494660 | chrX_154513578_- | intronic |
| ADediting_1494661 | chrX_154513586_- | intronic |
| ADediting_1494662 | chrX_154513592_- | intronic |
| ADediting_1494663 | chrX_154513615_- | intronic |
| ADediting_1494664 | chrX_154514316_- | intronic |
| ADediting_1494665 | chrX_154514471_- | intronic |
| ADediting_1494666 | chrX_154514472_- | intronic |
| ADediting_1494667 | chrX_154514532_- | intronic |
| ADediting_1494668 | chrX_154514536_- | intronic |
| ADediting_1494669 | chrX_154514542_- | intronic |
| ADediting_1494670 | chrX_154514821_- | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_1494652 | chrX_154512317_- | SINE | Alu | Name=AluSz6 |
| ADediting_1494653 | chrX_154512382_- | SINE | Alu | Name=AluSz6 |
| ADediting_1494654 | chrX_154512401_- | SINE | Alu | Name=AluSz6 |
| ADediting_1494655 | chrX_154513375_- | SINE | Alu | Name=AluSg |
| ADediting_1494656 | chrX_154513387_- | SINE | Alu | Name=AluSg |
| ADediting_1494657 | chrX_154513413_- | SINE | Alu | Name=AluSg |
| ADediting_1494658 | chrX_154513508_- | SINE | Alu | Name=AluSg |
| ADediting_1494659 | chrX_154513518_- | SINE | Alu | Name=AluSg |
| ADediting_1494660 | chrX_154513578_- | SINE | Alu | Name=AluSg |
| ADediting_1494661 | chrX_154513586_- | SINE | Alu | Name=AluSg |
| ADediting_1494662 | chrX_154513592_- | SINE | Alu | Name=AluSg |
| ADediting_1494663 | chrX_154513615_- | SINE | Alu | Name=AluSg |
| ADediting_1494664 | chrX_154514316_- | SINE | Alu | Name=AluSq2 |
| ADediting_1494665 | chrX_154514471_- | SINE | Alu | Name=AluY |
| ADediting_1494666 | chrX_154514472_- | SINE | Alu | Name=AluY |
| ADediting_1494667 | chrX_154514532_- | SINE | Alu | Name=AluY |
| ADediting_1494668 | chrX_154514536_- | SINE | Alu | Name=AluY |
| ADediting_1494669 | chrX_154514542_- | SINE | Alu | Name=AluY |
| ADediting_1494670 | chrX_154514821_- | SINE | Alu | Name=AluSq2 |
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RNA A-to-I editing events in the alternative splicing sites for FAM3A |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for FAM3A |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for FAM3A |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for FAM3A |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000071889.16 | ENST00000322269.10 | FAM3A-201 | hsa-miR-5688 | chrX | 154506221 | 154506228 | 8mer-1a | 154506221 | 154506242 | 143 | -13.45 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000071889.16 | ENST00000359889.9 | FAM3A-202 | hsa-miR-5688 | chrX | 154506221 | 154506228 | 8mer-1a | 154506221 | 154506242 | 143 | -13.45 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000071889.16 | ENST00000369643.5 | FAM3A-204 | hsa-miR-5688 | chrX | 154506221 | 154506228 | 8mer-1a | 154506221 | 154506242 | 143 | -13.45 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000071889.16 | ENST00000419205.5 | FAM3A-208 | hsa-miR-5688 | chrX | 154506221 | 154506228 | 8mer-1a | 154506221 | 154506242 | 143 | -13.45 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000071889.16 | ENST00000447601.6 | FAM3A-215 | hsa-miR-5688 | chrX | 154506221 | 154506228 | 8mer-1a | 154506221 | 154506242 | 143 | -13.45 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_291761 | chr11_93733708_- | ENSG00000071889.16 | ENST00000322269.10 | FAM3A-201 | hsa-miR-1304-3p | chrX | 154506349 | 154506355 | 7mer-m8 | 154506348 | 154506371 | 146 | -14.98 |
| ADediting_291761 | chr11_93733708_- | ENSG00000071889.16 | ENST00000359889.9 | FAM3A-202 | hsa-miR-1304-3p | chrX | 154506349 | 154506355 | 7mer-m8 | 154506348 | 154506371 | 146 | -14.98 |
| ADediting_291761 | chr11_93733708_- | ENSG00000071889.16 | ENST00000369643.5 | FAM3A-204 | hsa-miR-1304-3p | chrX | 154506349 | 154506355 | 7mer-m8 | 154506348 | 154506371 | 146 | -14.98 |
| ADediting_291761 | chr11_93733708_- | ENSG00000071889.16 | ENST00000419205.5 | FAM3A-208 | hsa-miR-1304-3p | chrX | 154506349 | 154506355 | 7mer-m8 | 154506348 | 154506371 | 146 | -14.98 |
| ADediting_291761 | chr11_93733708_- | ENSG00000071889.16 | ENST00000447601.6 | FAM3A-215 | hsa-miR-1304-3p | chrX | 154506349 | 154506355 | 7mer-m8 | 154506348 | 154506371 | 146 | -14.98 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for FAM3A |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000322269.10 | protein_coding |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_1494652 | ENST00000322269.10 | chrX_154512317_- | 595 | -814.00 | -814.00 | -819.20 |
| ADediting_1494653 | ENST00000322269.10 | chrX_154512382_- | 530 | -816.40 | -814.00 | -819.20 |
| ADediting_1494654 | ENST00000322269.10 | chrX_154512401_- | 511 | -817.80 | -814.00 | -819.20 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for FAM3A |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 1.42963587194308e-17 | 0.459153296010813 | 1.96379138428393e-25 | 0.54550975995432 | 4.49743475666821e-19 | 0.477658716595727 |
| AC | 9.9949239020052e-38 | 0.697265039741937 | 4.86369176449691e-24 | 0.581754105703773 | 6.38725174498493e-33 | 0.66215533978972 |
| PCC | 2.13751952008565e-14 | 0.516144823053069 | 6.51674892079327e-15 | 0.524829197416021 | 4.21292638079279e-06 | 0.32589314502261 |
| TCX | 0.00108102724611389 | 0.264323775309428 | 0.400578525711061 | -0.0691299063658577 | 5.49772199292653e-19 | 0.6446582873607 |
| FP | 2.17893297884635e-14 | 0.531875462680411 | 2.20021317494042e-10 | 0.45284873010217 | 1.14464431800808e-12 | 0.500372049989499 |
| IFG | 1.41125566121158e-05 | 0.752833210768491 | 7.36624197905885e-05 | 0.708587988834044 | 0.0293142304829571 | 0.436088864361185 |
| PG | 0.273823966860607 | -0.0806507857453879 | 0.581858942344651 | -0.0406344341872724 | 9.38008497738121e-08 | 0.379259931152972 |
| STG | 4.11238974393444e-12 | 0.667433404728947 | 1.09622315786078e-05 | 0.459543856234403 | 0.000180671573948429 | 0.397552573871056 |
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Relation with AD stages for FAM3A |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
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RelatedDrugs for FAM3A |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FAM3A |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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