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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for RGS3 |
 Gene summary |
| Gene information | Gene symbol | RGS3 | Gene ID | 5998 |
| Gene name | regulator of G protein signaling 3 | |
| Synonyms | C2PA|RGP3 | |
| Cytomap | 9q32 | |
| Type of gene | protein-coding | |
| Description | regulator of G-protein signaling 3regulator of G-protein signalling 3 | |
| Modification date | 20200320 | |
| UniProtAcc | P49796, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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RNA A-to-I events for RGS3 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_1433199(113500741, +), ADediting_1433200(113500890, +), ADediting_1433201(113500925, +), ADediting_1433202(113545876, +), ADediting_1433203(113552360, +), ADediting_1433204(113552434, +), ADediting_1433205(113552503, +), ADediting_1433206(113552525, +), ADediting_1433207(113552556, +), ADediting_1433208(113553251, +), ADediting_1433209(113553340, +), ADediting_1433210(113593260, +), ADediting_1433211(113596223, +), ADediting_1592052(113593249, +), ADediting_1592053(113593526, +), ADediting_1671708(113550172, +), ADediting_1671709(113550187, +), |
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RNA editing positional annotations for RGS3 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_1433199 | chr9_113500741_+ | intronic |
| ADediting_1433200 | chr9_113500890_+ | intronic |
| ADediting_1433201 | chr9_113500925_+ | intronic |
| ADediting_1433202 | chr9_113545876_+ | intronic |
| ADediting_1433203 | chr9_113552360_+ | intronic |
| ADediting_1433204 | chr9_113552434_+ | intronic |
| ADediting_1433205 | chr9_113552503_+ | intronic |
| ADediting_1433206 | chr9_113552525_+ | intronic |
| ADediting_1433207 | chr9_113552556_+ | intronic |
| ADediting_1433208 | chr9_113553251_+ | intronic |
| ADediting_1433209 | chr9_113553340_+ | intronic |
| ADediting_1433210 | chr9_113593260_+ | intronic |
| ADediting_1433211 | chr9_113596223_+ | intronic |
| ADediting_1592052 | chr9_113593249_+ | intronic |
| ADediting_1592053 | chr9_113593526_+ | UTR5 |
| ADediting_1671708 | chr9_113550172_+ | intronic |
| ADediting_1671709 | chr9_113550187_+ | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_1433199 | chr9_113500741_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1433200 | chr9_113500890_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1433201 | chr9_113500925_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1433202 | chr9_113545876_+ | SINE | MIR | Name=MIR |
| ADediting_1433203 | chr9_113552360_+ | SINE | Alu | Name=AluY |
| ADediting_1433204 | chr9_113552434_+ | SINE | Alu | Name=AluY |
| ADediting_1433205 | chr9_113552503_+ | SINE | Alu | Name=AluY |
| ADediting_1433206 | chr9_113552525_+ | SINE | Alu | Name=AluY |
| ADediting_1433207 | chr9_113552556_+ | SINE | Alu | Name=AluY |
| ADediting_1433208 | chr9_113553251_+ | SINE | Alu | Name=AluJb |
| ADediting_1433209 | chr9_113553340_+ | SINE | Alu | Name=AluJb |
| ADediting_1433211 | chr9_113596223_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1671708 | chr9_113550172_+ | SINE | Alu | Name=AluSx3 |
| ADediting_1671709 | chr9_113550187_+ | SINE | Alu | Name=AluSx3 |
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RNA A-to-I editing events in the alternative splicing sites for RGS3 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for RGS3 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for RGS3 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for RGS3 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for RGS3 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000462403.5 | protein_coding |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_1592053 | ENST00000462403.5 | chr9_113593526_+ | 41 | -896.40 | -896.40 | -896.40 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for RGS3 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 4.40683543062432e-07 | 0.282139638003883 | 4.61207389025726e-06 | 0.256881154075086 | 2.22407709247548e-10 | 0.350304882091218 |
| AC | 8.04223560711097e-28 | 0.618869067462523 | 2.46949393582707e-14 | 0.45746795907144 | 2.49516254500744e-38 | 0.701336824173592 |
| PCC | 0.0167225719633509 | 0.172961867239068 | 0.00327486148819893 | 0.211752338700841 | 1.96632305207735e-05 | 0.303544226447546 |
| CER | 2.35307846649684e-06 | 0.374440800478467 | 0.000903936133731348 | 0.268241989787701 | 0.000128694706439475 | 0.307590983734682 |
| TCX | 0.00637719810022939 | 0.221792622997512 | 0.00342231764073926 | -0.237546404042239 | 2.8986543909029e-23 | 0.698486822187998 |
| FP | 1.61287516423184e-05 | 0.317101142928869 | 0.00095060547573525 | 0.245626268761942 | 1.01040875436793e-17 | 0.584900288456984 |
| IFG | 0.00959533625543122 | 0.507581032476722 | 0.00869352668730298 | 0.513246315222111 | 4.22926802515712e-06 | 0.780250027800696 |
| PG | 0.0488261634210035 | -0.144669635337985 | 3.54130208870548e-05 | -0.298309904610413 | 2.31875610248471e-09 | 0.420384236014048 |
| STG | 0.0261521193353141 | 0.242649390877037 | 0.733516314100371 | 0.0376979903067291 | 5.10077372619692e-13 | 0.687479871905207 |
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Relation with AD stages for RGS3 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| TCX | 3.77060902606093e-08 | 0.503493977432186 |
| PG | 7.48168351635117e-06 | 0.32184110433882 |
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RelatedDrugs for RGS3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RGS3 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| RGS3 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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