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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited versus non-edited samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with AD stages

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene


Gene summary for GNB4

check button Gene summary
Gene informationGene symbol

GNB4

Gene ID

59345

Gene nameG protein subunit beta 4
SynonymsCMTD1F
Cytomap

3q26.33

Type of geneprotein-coding
Descriptionguanine nucleotide-binding protein subunit beta-4G protein beta-4 subunitguanine nucleotide binding protein (G protein), beta polypeptide 4transducin beta chain 4
Modification date20200313
UniProtAcc

Q9HAV0,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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RNA A-to-I events for GNB4

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_1041522(179399225, -), ADediting_1041523(179399245, -), ADediting_1041524(179399250, -), ADediting_1041525(179399255, -), ADediting_1041526(179399260, -), ADediting_1041527(179399279, -), ADediting_1041528(179399299, -), ADediting_1041529(179399314, -), ADediting_1041530(179399318, -), ADediting_1041531(179399331, -), ADediting_1041532(179399335, -), ADediting_1041533(179399340, -), ADediting_1041534(179399341, -), ADediting_1041535(179399349, -), ADediting_1041536(179399351, -), ADediting_1041537(179399367, -), ADediting_1041538(179399373, -), ADediting_1041539(179399376, -), ADediting_1041540(179399378, -), ADediting_1041541(179399379, -), ADediting_1041542(179399380, -), ADediting_1041543(179399381, -), ADediting_1041544(179399382, -), ADediting_1041545(179399396, -), ADediting_1041546(179399397, -), ADediting_1041547(179399411, -), ADediting_1041548(179399416, -), ADediting_1041549(179399440, -), ADediting_1041550(179399445, -), ADediting_1041551(179399453, -), ADediting_1041552(179399454, -), ADediting_1041553(179399466, -), ADediting_1041554(179399475, -), ADediting_1041555(179399476, -), ADediting_1041556(179399478, -), ADediting_1041557(179399482, -), ADediting_1041558(179399484, -), ADediting_1041559(179399492, -), ADediting_1041560(179399494, -), ADediting_1041561(179406695, -), ADediting_1041562(179406750, -), ADediting_1041563(179406813, -), ADediting_1041564(179406814, -), ADediting_1041565(179407201, -), ADediting_1041566(179407203, -), ADediting_1041567(179407229, -), ADediting_1041568(179407242, -), ADediting_1041569(179407347, -), ADediting_1041570(179407376, -), ADediting_1041571(179407377, -), ADediting_1041572(179407396, -), ADediting_1041573(179417606, -), ADediting_1041574(179417607, -), ADediting_1041575(179417637, -), ADediting_1041576(179418282, -), ADediting_1041577(179418434, -), ADediting_1041578(179423616, -), ADediting_1041579(179423698, -), ADediting_1041580(179423705, -), ADediting_1041581(179430365, -), ADediting_1041582(179430381, -), ADediting_1041583(179431372, -), ADediting_1041584(179431394, -), ADediting_1041585(179438432, -), ADediting_1041586(179444652, -), ADediting_1041587(179445347, -), ADediting_1041588(179445361, -), ADediting_1041589(179445401, -), ADediting_1041590(179445558, -), ADediting_1572924(179399300, -), ADediting_1646123(179406777, -), ADediting_1646124(179406861, -), ADediting_1646125(179406887, -), ADediting_1646126(179407276, -), ADediting_1646127(179407359, -), ADediting_1646128(179417601, -), ADediting_1646129(179423669, -), ADediting_1646130(179430347, -), ADediting_1646131(179430375, -), ADediting_1646132(179441668, -), ADediting_1646133(179441669, -), ADediting_1646134(179441952, -), ADediting_1646135(179441972, -), ADediting_1646136(179442010, -), ADediting_1646137(179442011, -), ADediting_1646138(179442034, -),

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RNA editing positional annotations for GNB4 using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_1041522chr3_179399225_-UTR3
ADediting_1041523chr3_179399245_-UTR3
ADediting_1041524chr3_179399250_-UTR3
ADediting_1041525chr3_179399255_-UTR3
ADediting_1041526chr3_179399260_-UTR3
ADediting_1041527chr3_179399279_-UTR3
ADediting_1041528chr3_179399299_-UTR3
ADediting_1041529chr3_179399314_-UTR3
ADediting_1041530chr3_179399318_-UTR3
ADediting_1041531chr3_179399331_-UTR3
ADediting_1041532chr3_179399335_-UTR3
ADediting_1041533chr3_179399340_-UTR3
ADediting_1041534chr3_179399341_-UTR3
ADediting_1041535chr3_179399349_-UTR3
ADediting_1041536chr3_179399351_-UTR3
ADediting_1041537chr3_179399367_-UTR3
ADediting_1041538chr3_179399373_-UTR3
ADediting_1041539chr3_179399376_-UTR3
ADediting_1041540chr3_179399378_-UTR3
ADediting_1041541chr3_179399379_-UTR3
ADediting_1041542chr3_179399380_-UTR3
ADediting_1041543chr3_179399381_-UTR3
ADediting_1041544chr3_179399382_-UTR3
ADediting_1041545chr3_179399396_-UTR3
ADediting_1041546chr3_179399397_-UTR3
ADediting_1041547chr3_179399411_-UTR3
ADediting_1041548chr3_179399416_-UTR3
ADediting_1041549chr3_179399440_-UTR3
ADediting_1041550chr3_179399445_-UTR3
ADediting_1041551chr3_179399453_-UTR3
ADediting_1041552chr3_179399454_-UTR3
ADediting_1041553chr3_179399466_-UTR3
ADediting_1041554chr3_179399475_-UTR3
ADediting_1041555chr3_179399476_-UTR3
ADediting_1041556chr3_179399478_-UTR3
ADediting_1041557chr3_179399482_-UTR3
ADediting_1041558chr3_179399484_-UTR3
ADediting_1041559chr3_179399492_-UTR3
ADediting_1041560chr3_179399494_-UTR3
ADediting_1041561chr3_179406695_-intronic
ADediting_1041562chr3_179406750_-intronic
ADediting_1041563chr3_179406813_-intronic
ADediting_1041564chr3_179406814_-intronic
ADediting_1041565chr3_179407201_-intronic
ADediting_1041566chr3_179407203_-intronic
ADediting_1041567chr3_179407229_-intronic
ADediting_1041568chr3_179407242_-intronic
ADediting_1041569chr3_179407347_-intronic
ADediting_1041570chr3_179407376_-intronic
ADediting_1041571chr3_179407377_-intronic
ADediting_1041572chr3_179407396_-intronic
ADediting_1041573chr3_179417606_-intronic
ADediting_1041574chr3_179417607_-intronic
ADediting_1041575chr3_179417637_-intronic
ADediting_1041576chr3_179418282_-intronic
ADediting_1041577chr3_179418434_-intronic
ADediting_1041578chr3_179423616_-intronic
ADediting_1041579chr3_179423698_-intronic
ADediting_1041580chr3_179423705_-intronic
ADediting_1041581chr3_179430365_-intronic
ADediting_1041582chr3_179430381_-intronic
ADediting_1041583chr3_179431372_-intronic
ADediting_1041584chr3_179431394_-intronic
ADediting_1041585chr3_179438432_-intronic
ADediting_1041586chr3_179444652_-intronic
ADediting_1041587chr3_179445347_-intronic
ADediting_1041588chr3_179445361_-intronic
ADediting_1041589chr3_179445401_-intronic
ADediting_1041590chr3_179445558_-intronic
ADediting_1572924chr3_179399300_-UTR3
ADediting_1646123chr3_179406777_-intronic
ADediting_1646124chr3_179406861_-intronic
ADediting_1646125chr3_179406887_-intronic
ADediting_1646126chr3_179407276_-intronic
ADediting_1646127chr3_179407359_-intronic
ADediting_1646128chr3_179417601_-intronic
ADediting_1646129chr3_179423669_-intronic
ADediting_1646130chr3_179430347_-intronic
ADediting_1646131chr3_179430375_-intronic
ADediting_1646132chr3_179441668_-intronic
ADediting_1646133chr3_179441669_-intronic
ADediting_1646134chr3_179441952_-intronic
ADediting_1646135chr3_179441972_-intronic
ADediting_1646136chr3_179442010_-intronic
ADediting_1646137chr3_179442011_-intronic
ADediting_1646138chr3_179442034_-intronic

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_1041522chr3_179399225_-SINEAluName=AluSz
ADediting_1041523chr3_179399245_-SINEAluName=AluSz
ADediting_1041524chr3_179399250_-SINEAluName=AluSz
ADediting_1041525chr3_179399255_-SINEAluName=AluSz
ADediting_1041526chr3_179399260_-SINEAluName=AluSz
ADediting_1041527chr3_179399279_-SINEAluName=AluSz
ADediting_1041528chr3_179399299_-SINEAluName=AluSz
ADediting_1041529chr3_179399314_-SINEAluName=AluSz
ADediting_1041530chr3_179399318_-SINEAluName=AluSz
ADediting_1041531chr3_179399331_-SINEAluName=AluSz
ADediting_1041532chr3_179399335_-SINEAluName=AluSz
ADediting_1041533chr3_179399340_-SINEAluName=AluSz
ADediting_1041534chr3_179399341_-SINEAluName=AluSz
ADediting_1041535chr3_179399349_-SINEAluName=AluSz
ADediting_1041536chr3_179399351_-SINEAluName=AluSz
ADediting_1041537chr3_179399367_-SINEAluName=AluSz
ADediting_1041538chr3_179399373_-SINEAluName=AluSz
ADediting_1041539chr3_179399376_-SINEAluName=AluSz
ADediting_1041540chr3_179399378_-SINEAluName=AluSz
ADediting_1041541chr3_179399379_-SINEAluName=AluSz
ADediting_1041542chr3_179399380_-SINEAluName=AluSz
ADediting_1041543chr3_179399381_-SINEAluName=AluSz
ADediting_1041544chr3_179399382_-SINEAluName=AluSz
ADediting_1041545chr3_179399396_-SINEAluName=AluSz
ADediting_1041546chr3_179399397_-SINEAluName=AluSz
ADediting_1041547chr3_179399411_-SINEAluName=AluSz
ADediting_1041548chr3_179399416_-SINEAluName=AluSz
ADediting_1041549chr3_179399440_-SINEAluName=AluSz
ADediting_1041550chr3_179399445_-SINEAluName=AluSz
ADediting_1041551chr3_179399453_-SINEAluName=AluSz
ADediting_1041552chr3_179399454_-SINEAluName=AluSz
ADediting_1041553chr3_179399466_-SINEAluName=AluSz
ADediting_1041554chr3_179399475_-SINEAluName=AluSz
ADediting_1041555chr3_179399476_-SINEAluName=AluSz
ADediting_1041556chr3_179399478_-SINEAluName=AluSz
ADediting_1041557chr3_179399482_-SINEAluName=AluSz
ADediting_1041558chr3_179399484_-SINEAluName=AluSz
ADediting_1041559chr3_179399492_-SINEAluName=AluSz
ADediting_1041560chr3_179399494_-SINEAluName=AluSz
ADediting_1041561chr3_179406695_-SINEAluName=AluSz
ADediting_1041562chr3_179406750_-SINEAluName=AluSz
ADediting_1041563chr3_179406813_-SINEAluName=AluSz
ADediting_1041564chr3_179406814_-SINEAluName=AluSz
ADediting_1041565chr3_179407201_-SINEAluName=AluSx1
ADediting_1041566chr3_179407203_-SINEAluName=AluSx1
ADediting_1041567chr3_179407229_-SINEAluName=AluSx1
ADediting_1041568chr3_179407242_-SINEAluName=AluSx1
ADediting_1041569chr3_179407347_-SINEAluName=AluSx1
ADediting_1041570chr3_179407376_-SINEAluName=AluSx1
ADediting_1041571chr3_179407377_-SINEAluName=AluSx1
ADediting_1041572chr3_179407396_-SINEAluName=AluSx1
ADediting_1041573chr3_179417606_-SINEAluName=AluSz
ADediting_1041574chr3_179417607_-SINEAluName=AluSz
ADediting_1041575chr3_179417637_-SINEAluName=AluSz
ADediting_1041576chr3_179418282_-SINEAluName=AluSq2
ADediting_1041577chr3_179418434_-SINEAluName=AluSq2
ADediting_1041578chr3_179423616_-SINEAluName=AluSc
ADediting_1041579chr3_179423698_-SINEAluName=AluSc
ADediting_1041580chr3_179423705_-SINEAluName=AluSc
ADediting_1041581chr3_179430365_-SINEAluName=AluJb
ADediting_1041582chr3_179430381_-SINEAluName=AluJb
ADediting_1041583chr3_179431372_-SINEAluName=AluSz6
ADediting_1041584chr3_179431394_-SINEAluName=AluSz6
ADediting_1041585chr3_179438432_-SINEMIRName=MIRb
ADediting_1041586chr3_179444652_-SINEAluName=AluJb
ADediting_1041587chr3_179445347_-SINEAluName=AluJb
ADediting_1041588chr3_179445361_-SINEAluName=AluJb
ADediting_1041589chr3_179445401_-SINEAluName=AluJb
ADediting_1041590chr3_179445558_-SINEAluName=AluJb
ADediting_1572924chr3_179399300_-SINEAluName=AluSz
ADediting_1646123chr3_179406777_-SINEAluName=AluSz
ADediting_1646124chr3_179406861_-SINEAluName=AluSz
ADediting_1646125chr3_179406887_-SINEAluName=AluSz
ADediting_1646126chr3_179407276_-SINEAluName=AluSx1
ADediting_1646127chr3_179407359_-SINEAluName=AluSx1
ADediting_1646128chr3_179417601_-SINEAluName=AluSz
ADediting_1646129chr3_179423669_-SINEAluName=AluSc
ADediting_1646130chr3_179430347_-SINEAluName=AluJb
ADediting_1646131chr3_179430375_-SINEAluName=AluJb
ADediting_1646132chr3_179441668_-SINEAluName=AluSx1
ADediting_1646133chr3_179441669_-SINEAluName=AluSx1
ADediting_1646134chr3_179441952_-SINEAluName=AluSq
ADediting_1646135chr3_179441972_-SINEAluName=AluSq
ADediting_1646136chr3_179442010_-SINEAluName=AluSq
ADediting_1646137chr3_179442011_-SINEAluName=AluSq
ADediting_1646138chr3_179442034_-SINEAluName=AluSq

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RNA A-to-I editing events in the alternative splicing sites for GNB4

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for GNB4

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
Soverview
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check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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ADeditome IDChrPositoingSkipped exonENSGENSTs

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Protein coding region RNA A-to-I editings for GNB4

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for GNB4

check buttonRNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
all structure

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1041524chr3_179399250_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-1295achr31793992451793992517mer-m8179399244179399264150-19.83
ADediting_1041524chr3_179399250_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-4743-5pchr31793992471793992537mer-m8179399246179399265147-26.03
ADediting_1041528chr3_179399299_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-24-3pchr31793992971793993037mer-m8179399296179399317141-14.5
ADediting_1041528chr3_179399299_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-3934-3pchr31793992981793993047mer-m8179399297179399318147-16.11
ADediting_1041528chr3_179399299_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-4437chr31793992961793993027mer-m8179399295179399315150-22.47
ADediting_1041530chr3_179399318_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-1913chr31793993131793993197mer-m8179399312179399333147-24.36
ADediting_1041530chr3_179399318_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-6849-3pchr31793993181793993247mer-m8179399317179399338140-15.93
ADediting_1041531chr3_179399331_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-1207-3pchr31793993311793993377mer-m8179399330179399347140-12.56
ADediting_1041531chr3_179399331_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-646chr31793993291793993357mer-m8179399328179399346145-14.99
ADediting_1041534chr3_179399341_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-513a-5pchr31793993401793993467mer-m8179399339179399356164-23.48
ADediting_1041534chr3_179399341_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-638chr31793993351793993417mer-1a179399335179399359155-30.36
ADediting_1041536chr3_179399351_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-4787-3pchr31793993481793993547mer-m8179399347179399368170-33.36
ADediting_1041538chr3_179399373_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-4742-3pchr31793993721793993798mer-1a179399372179399394142-9.18
ADediting_1041538chr3_179399373_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-654-3pchr31793993691793993757mer-m8179399368179399389140-10.44
ADediting_1041539chr3_179399376_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-153-5pchr31793993761793993827mer-m8179399375179399396144-8.16
ADediting_1041539chr3_179399376_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-3680-3pchr31793993721793993787mer-m8179399371179399393140-14.15
ADediting_1041542chr3_179399380_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-630chr31793993741793993818mer-1a179399374179399394158-15.13
ADediting_1041543chr3_179399381_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-518d-5pchr31793993791793993857mer-1a179399379179399401143-12.05
ADediting_1041543chr3_179399381_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-518e-5pchr31793993791793993857mer-1a179399379179399401151-12.91
ADediting_1041543chr3_179399381_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-518f-5pchr31793993791793993857mer-1a179399379179399401143-12.05
ADediting_1041543chr3_179399381_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-519a-5pchr31793993791793993857mer-1a179399379179399401151-12.91
ADediting_1041543chr3_179399381_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-519b-5pchr31793993791793993857mer-1a179399379179399401151-12.91
ADediting_1041543chr3_179399381_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-519c-5pchr31793993791793993857mer-1a179399379179399401151-12.91
ADediting_1041543chr3_179399381_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-520c-5pchr31793993791793993857mer-1a179399379179399401143-12.05
ADediting_1041543chr3_179399381_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-522-5pchr31793993791793993857mer-1a179399379179399401151-12.91
ADediting_1041543chr3_179399381_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-523-5pchr31793993791793993857mer-1a179399379179399401151-12.91
ADediting_1041543chr3_179399381_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-526a-5pchr31793993791793993857mer-1a179399379179399401143-12.05
ADediting_1041545chr3_179399396_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-412-3pchr31793993961793994027mer-m8179399395179399417149-13.63
ADediting_1041545chr3_179399396_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-6754-3pchr31793993961793994027mer-m8179399395179399417141-13.05
ADediting_1041546chr3_179399397_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-1229-3pchr31793993961793994027mer-m8179399395179399416146-14
ADediting_1041546chr3_179399397_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-6511a-3pchr31793993961793994038mer-1a179399396179399417145-13.51
ADediting_1041546chr3_179399397_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-6511b-3pchr31793993961793994038mer-1a179399396179399418140-12.9
ADediting_1041547chr3_179399411_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-6721-5pchr31793994071793994148mer-1a179399407179399427143-20.85
ADediting_1041548chr3_179399416_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-1295achr31793994111793994177mer-m8179399410179399430140-13.96
ADediting_1041551chr3_179399453_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-3176chr31793994531793994597mer-m8179399452179399470140-15.24
ADediting_1041551chr3_179399453_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-3620-3pchr31793994491793994557mer-m8179399448179399470156-24.24
ADediting_1041551chr3_179399453_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-3922-3pchr31793994531793994597mer-m8179399452179399474147-21.07
ADediting_1041553chr3_179399466_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-3692-5pchr31793994661793994727mer-m8179399465179399490146-16.8
ADediting_1041553chr3_179399466_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-548av-3pchr31793994631793994697mer-m8179399462179399481145-7.89
ADediting_1041554chr3_179399475_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-3199chr31793994701793994767mer-1a179399470179399489141-18.27
ADediting_1041554chr3_179399475_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-625-3pchr31793994741793994807mer-m8179399473179399494144-16.68
ADediting_1041554chr3_179399475_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-8052chr31793994701793994767mer-1a179399470179399490141-22.27
ADediting_1041556chr3_179399478_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-10399-5pchr31793994741793994807mer-m8179399473179399494144-8.91
ADediting_1041556chr3_179399478_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-3934-5pchr31793994781793994847mer-m8179399477179399499147-19.37
ADediting_1041556chr3_179399478_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-552-3pchr31793994761793994838mer-1a179399476179399496140-14.05
ADediting_1041556chr3_179399478_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-6504-3pchr31793994741793994807mer-m8179399473179399494149-19.51
ADediting_1041559chr3_179399492_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-3620-3pchr31793994891793994957mer-m8179399488179399507149-24.52
ADediting_1041559chr3_179399492_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-6752-3pchr31793994911793994977mer-m8179399490179399512149-20.52

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1041522chr3_179399225_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-3198chr31793992251793992317mer-m8179399224179399245140-14.76
ADediting_1041522chr3_179399225_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-4309chr31793992251793992317mer-m8179399224179399241145-15.52
ADediting_1041522chr3_179399225_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-4534chr31793992231793992297mer-m8179399222179399238140-14.2
ADediting_1041522chr3_179399225_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-6514-5pchr31793992241793992307mer-m8179399223179399246146-15.81
ADediting_1041522chr3_179399225_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-8082chr31793992231793992297mer-m8179399222179399244141-22.09
ADediting_1041524chr3_179399250_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-3652chr31793992471793992537mer-m8179399246179399265148-20.61
ADediting_1041526chr3_179399260_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-5693chr31793992571793992637mer-m8179399256179399277142-18.63
ADediting_1041526chr3_179399260_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-891a-3pchr31793992591793992657mer-m8179399258179399280152-19.33
ADediting_1041529chr3_179399314_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-1976chr31793993091793993168mer-1a179399309179399329149-24.39
ADediting_1041529chr3_179399314_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-6747-3pchr31793993111793993188mer-1a179399311179399333149-23.68
ADediting_1041532chr3_179399335_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-5089-5pchr31793993351793993417mer-m8179399334179399355146-13.21
ADediting_1041533chr3_179399340_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-5089-5pchr31793993351793993417mer-m8179399334179399355146-13.21
ADediting_1041533chr3_179399340_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-6504-3pchr31793993391793993457mer-m8179399338179399359145-12.4
ADediting_1041534chr3_179399341_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-6504-3pchr31793993391793993457mer-m8179399338179399359145-12.4
ADediting_1041535chr3_179399349_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-1-3pchr31793993451793993517mer-m8179399344179399365140-13
ADediting_1041535chr3_179399349_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-206chr31793993451793993517mer-m8179399344179399365140-16.32
ADediting_1041535chr3_179399349_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-455-5pchr31793993481793993547mer-m8179399347179399368140-17.76
ADediting_1041535chr3_179399349_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-613chr31793993451793993517mer-m8179399344179399363150-22.38
ADediting_1041536chr3_179399351_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-1227-3pchr31793993491793993568mer-1a179399349179399368147-19.38
ADediting_1041536chr3_179399351_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-455-5pchr31793993481793993547mer-m8179399347179399368140-17.76
ADediting_1041536chr3_179399351_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-4715-3pchr31793993511793993577mer-m8179399350179399372143-20.26
ADediting_1041538chr3_179399373_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-33a-3pchr31793993671793993748mer-1a179399367179399388140-3.46
ADediting_1041545chr3_179399396_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-193b-5pchr31793993911793993988mer-1a179399391179399412142-14.46
ADediting_1041545chr3_179399396_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-3170chr31793993911793993977mer-m8179399390179399411140-13.62
ADediting_1041545chr3_179399396_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-6855-5pchr31793993911793993977mer-m8179399390179399414145-18
ADediting_1041546chr3_179399397_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-193b-5pchr31793993911793993988mer-1a179399391179399412142-14.46
ADediting_1041547chr3_179399411_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-1229-5pchr31793994061793994138mer-1a179399406179399427155-25.77
ADediting_1041548chr3_179399416_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-6131chr31793994141793994207mer-m8179399413179399431140-19.08
ADediting_1041549chr3_179399440_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-1245achr31793994381793994447mer-m8179399437179399453150-21.07
ADediting_1041549chr3_179399440_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-8079chr31793994381793994447mer-m8179399437179399456149-16.35
ADediting_1041552chr3_179399454_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-6878-3pchr31793994531793994608mer-1a179399453179399475143-15.23
ADediting_1041553chr3_179399466_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-302fchr31793994641793994707mer-m8179399463179399479141-6.19
ADediting_1041554chr3_179399475_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-5089-5pchr31793994701793994767mer-m8179399469179399490148-12.98

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1535953chr14_101045971_+ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-381-3pchr31793964311793964377mer-m8179396430179396454147-14.35
ADediting_1556067chr19_40282625_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-641chr31793972291793972368mer-1a179397229179397253147-12.57
ADediting_843620chr2_207754818_+ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-4775chr31793996251793996317mer-m8179399624179399645140-7.05

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1337757chr7_5495852_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-589-3pchr31794001231794001297mer-m8179400122179400145150-15.37
ADediting_1535953chr14_101045971_+ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-381-3pchr31793962041793962107mer-m8179396203179396224148-10.07
ADediting_1535953chr14_101045971_+ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-381-3pchr31793967171793967237mer-m8179396716179396737145-12.2
ADediting_1535954chr14_101045974_+ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-381-3pchr31793962041793962107mer-m8179396203179396224148-10.07
ADediting_1535954chr14_101045974_+ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-381-3pchr31793967171793967237mer-m8179396716179396737145-12.2
ADediting_1596844chr1_162342605_+ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-556-3pchr31794005021794005087mer-m8179400501179400523142-7.42
ADediting_286380chr11_79422188_-ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-5579-3pchr31793967761793967827mer-m8179396775179396795144-9.53
ADediting_843620chr2_207754818_+ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-4775chr31793963701793963767mer-m8179396369179396390140-4.16
ADediting_843620chr2_207754818_+ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-4775chr31793970651793970728mer-1a179397065179397090146-13.03
ADediting_843620chr2_207754818_+ENSG00000114450.10ENST00000232564.8GNB4-201hsa-miR-4775chr31793989251793989317mer-m8179398924179398950146-8.87

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for GNB4

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.
ENST00000232564.8protein_codingSoverviewSoverview

check button RNA A-to-I editing in miRNA.
ADeditom_IDENSTmir_IDEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in mRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI
ADediting_1041522ENST00000232564.8chr3_179399225_-3178-1930.00-1926.60-1959.60
ADediting_1041523ENST00000232564.8chr3_179399245_-3158-1933.20-1926.60-1959.60
ADediting_1041524ENST00000232564.8chr3_179399250_-3153-1925.90-1926.60-1959.60
ADediting_1041525ENST00000232564.8chr3_179399255_-3148-1926.20-1926.60-1959.60
ADediting_1041526ENST00000232564.8chr3_179399260_-3143-1926.20-1926.60-1959.60
ADediting_1041527ENST00000232564.8chr3_179399279_-3124-1925.80-1926.60-1959.60
ADediting_1041528ENST00000232564.8chr3_179399299_-3104-1926.60-1926.60-1959.60
ADediting_1572924ENST00000232564.8chr3_179399300_-3103-1926.10-1926.60-1959.60
ADediting_1041529ENST00000232564.8chr3_179399314_-3089-1925.90-1926.60-1959.60
ADediting_1041530ENST00000232564.8chr3_179399318_-3085-1925.70-1926.60-1959.60
ADediting_1041531ENST00000232564.8chr3_179399331_-3072-1926.60-1926.60-1959.60
ADediting_1041532ENST00000232564.8chr3_179399335_-3068-1925.90-1926.60-1959.60
ADediting_1041533ENST00000232564.8chr3_179399340_-3063-1932.80-1926.60-1959.60
ADediting_1041534ENST00000232564.8chr3_179399341_-3062-1926.30-1926.60-1959.60
ADediting_1041535ENST00000232564.8chr3_179399349_-3054-1926.20-1926.60-1959.60
ADediting_1041536ENST00000232564.8chr3_179399351_-3052-1926.20-1926.60-1959.60
ADediting_1041537ENST00000232564.8chr3_179399367_-3036-1926.30-1926.60-1959.60
ADediting_1041538ENST00000232564.8chr3_179399373_-3030-1927.00-1926.60-1959.60
ADediting_1041539ENST00000232564.8chr3_179399376_-3027-1929.90-1926.60-1959.60
ADediting_1041540ENST00000232564.8chr3_179399378_-3025-1926.60-1926.60-1959.60
ADediting_1041541ENST00000232564.8chr3_179399379_-3024-1927.30-1926.60-1959.60
ADediting_1041542ENST00000232564.8chr3_179399380_-3023-1927.10-1926.60-1959.60
ADediting_1041543ENST00000232564.8chr3_179399381_-3022-1926.60-1926.60-1959.60
ADediting_1041544ENST00000232564.8chr3_179399382_-3021-1926.90-1926.60-1959.60
ADediting_1041545ENST00000232564.8chr3_179399396_-3007-1928.20-1926.60-1959.60
ADediting_1041546ENST00000232564.8chr3_179399397_-3006-1927.80-1926.60-1959.60
ADediting_1041547ENST00000232564.8chr3_179399411_-2992-1928.10-1926.60-1959.60
ADediting_1041548ENST00000232564.8chr3_179399416_-2987-1928.40-1926.60-1959.60
ADediting_1041549ENST00000232564.8chr3_179399440_-2963-1930.30-1926.60-1959.60
ADediting_1041550ENST00000232564.8chr3_179399445_-2958-1929.70-1926.60-1959.60
ADediting_1041551ENST00000232564.8chr3_179399453_-2950-1927.00-1926.60-1959.60
ADediting_1041552ENST00000232564.8chr3_179399454_-2949-1926.60-1926.60-1959.60
ADediting_1041553ENST00000232564.8chr3_179399466_-2937-1926.60-1926.60-1959.60
ADediting_1041554ENST00000232564.8chr3_179399475_-2928-1927.10-1926.60-1959.60
ADediting_1041555ENST00000232564.8chr3_179399476_-2927-1926.70-1926.60-1959.60
ADediting_1041556ENST00000232564.8chr3_179399478_-2925-1929.70-1926.60-1959.60
ADediting_1041557ENST00000232564.8chr3_179399482_-2921-1929.10-1926.60-1959.60
ADediting_1041558ENST00000232564.8chr3_179399484_-2919-1926.60-1926.60-1959.60
ADediting_1041559ENST00000232564.8chr3_179399492_-2911-1930.40-1926.60-1959.60
ADediting_1041560ENST00000232564.8chr3_179399494_-2909-1927.40-1926.60-1959.60

check button RNA A-to-I editing in lncRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for GNB4

check button Correlation between ADAR gene expression and RNA editing frequency
TissueADeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)

check button Correlation between ADAR gene expression and this gene's expression
TissueADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFC2.89589229510492e-110.3660792709813320.01845822466516180.133766994986951.33548641561775e-290.582868208633137
AC4.60218421266591e-580.8046027397058747.12520502270722e-260.6003598066938174.92263387255977e-180.51102609353728
PCC2.20061123329972e-180.5775464376026233.29384638856037e-110.4562291631250794.16700170585308e-060.326045910512504
CER3.87169193429869e-060.3669046518538360.1001422735872090.1347596970907481.2253769504877e-050.348700589876102
TCX3.47133166254258e-180.6332364042590060.002830282335478730.2421595503642250.02192309894472970.187026666246854
FP2.47146394598058e-190.6074618515423562.50352825246614e-210.6331035673577770.0116308028172690.188745051252417
IFG0.002408736994816060.5793060481416230.01604636556436190.4764590579951410.1378437850888810.305265254036932
PG1.38384423299867e-390.7817190183709854.1512328118861e-180.5799749391272330.6529883816532110.0331819482068966
STG3.55775914065224e-070.5219063976593250.0008055726692694040.3587355991284470.4260889359716550.0879898499573471

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Relation with AD stages for GNB4

check button Correlation between AD stages and RNA editing frequency
TissueADeditomIDpositionP-valCoeff.
TCXADediting_1041523chr3_179399245_-0.0007344811792671560.322938514045419
TCXADediting_1041533chr3_179399340_-0.0002788149186987040.346115742154211
TCXADediting_1041552chr3_179399454_-0.0006195559517093920.327143515910356

check button Correlation between AD stages and this gene's expression
TissueP-valCoeff.
TCX6.44272441120108e-060.422488764102926

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RelatedDrugs for GNB4

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GNB4

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource
GNB4C0007959Charcot-Marie-Tooth Disease1GENOMICS_ENGLAND
GNB4C0009402Colorectal Carcinoma1CTD_human
GNB4C0009404Colorectal Neoplasms1CTD_human
GNB4C1527249Colorectal Cancer1CTD_human
GNB4C3554654CHARCOT-MARIE-TOOTH DISEASE, DOMINANT INTERMEDIATE F1CTD_human;ORPHANET;UNIPROT