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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited versus non-edited samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with AD stages

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene


Gene summary for PURB

check button Gene summary
Gene informationGene symbol

PURB

Gene ID

5814

Gene namepurine rich element binding protein B
SynonymsPURBETA
Cytomap

7p13

Type of geneprotein-coding
Descriptiontranscriptional activator protein Pur-beta
Modification date20200313
UniProtAcc

Q96QR8,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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RNA A-to-I events for PURB

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_1333992(44877546, -), ADediting_1333993(44877557, -), ADediting_1333994(44877558, -), ADediting_1333995(44877559, -), ADediting_1333996(44877637, -), ADediting_1333997(44877640, -), ADediting_1333998(44877646, -), ADediting_1333999(44877660, -), ADediting_1334000(44877679, -), ADediting_1334001(44877680, -), ADediting_1334002(44877682, -), ADediting_1334003(44877692, -), ADediting_1334004(44877695, -), ADediting_1334005(44877717, -), ADediting_1334006(44877721, -), ADediting_1334007(44877741, -), ADediting_1334008(44877752, -), ADediting_1334009(44877807, -), ADediting_1334010(44879071, -), ADediting_1334011(44879073, -), ADediting_1334012(44879109, -), ADediting_1334013(44879129, -), ADediting_1334014(44879137, -), ADediting_1334015(44879169, -), ADediting_1334016(44879173, -), ADediting_1334017(44879179, -), ADediting_1334018(44879205, -), ADediting_1334019(44879214, -), ADediting_1334020(44879244, -), ADediting_1334021(44879294, -), ADediting_1334022(44879299, -), ADediting_1334023(44879300, -), ADediting_1334024(44880792, -), ADediting_1334025(44881040, -), ADediting_1587637(44877540, -), ADediting_1587638(44877722, -), ADediting_1587639(44879223, -), ADediting_1587640(44879234, -), ADediting_1587641(44879235, -), ADediting_1587642(44879236, -),

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RNA editing positional annotations for PURB using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_1333992chr7_44877546_-UTR3
ADediting_1333993chr7_44877557_-UTR3
ADediting_1333994chr7_44877558_-UTR3
ADediting_1333995chr7_44877559_-UTR3
ADediting_1333996chr7_44877637_-UTR3
ADediting_1333997chr7_44877640_-UTR3
ADediting_1333998chr7_44877646_-UTR3
ADediting_1333999chr7_44877660_-UTR3
ADediting_1334000chr7_44877679_-UTR3
ADediting_1334001chr7_44877680_-UTR3
ADediting_1334002chr7_44877682_-UTR3
ADediting_1334003chr7_44877692_-UTR3
ADediting_1334004chr7_44877695_-UTR3
ADediting_1334005chr7_44877717_-UTR3
ADediting_1334006chr7_44877721_-UTR3
ADediting_1334007chr7_44877741_-UTR3
ADediting_1334008chr7_44877752_-UTR3
ADediting_1334009chr7_44877807_-UTR3
ADediting_1334010chr7_44879071_-UTR3
ADediting_1334011chr7_44879073_-UTR3
ADediting_1334012chr7_44879109_-UTR3
ADediting_1334013chr7_44879129_-UTR3
ADediting_1334014chr7_44879137_-UTR3
ADediting_1334015chr7_44879169_-UTR3
ADediting_1334016chr7_44879173_-UTR3
ADediting_1334017chr7_44879179_-UTR3
ADediting_1334018chr7_44879205_-UTR3
ADediting_1334019chr7_44879214_-UTR3
ADediting_1334020chr7_44879244_-UTR3
ADediting_1334021chr7_44879294_-UTR3
ADediting_1334022chr7_44879299_-UTR3
ADediting_1334023chr7_44879300_-UTR3
ADediting_1334024chr7_44880792_-UTR3
ADediting_1334025chr7_44881040_-UTR3
ADediting_1587637chr7_44877540_-UTR3
ADediting_1587638chr7_44877722_-UTR3
ADediting_1587639chr7_44879223_-UTR3
ADediting_1587640chr7_44879234_-UTR3
ADediting_1587641chr7_44879235_-UTR3
ADediting_1587642chr7_44879236_-UTR3

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_1333992chr7_44877546_-SINEAluName=AluSz
ADediting_1333993chr7_44877557_-SINEAluName=AluSz
ADediting_1333994chr7_44877558_-SINEAluName=AluSz
ADediting_1333995chr7_44877559_-SINEAluName=AluSz
ADediting_1333996chr7_44877637_-SINEAluName=AluSz
ADediting_1333997chr7_44877640_-SINEAluName=AluSz
ADediting_1333998chr7_44877646_-SINEAluName=AluSz
ADediting_1333999chr7_44877660_-SINEAluName=AluSz
ADediting_1334000chr7_44877679_-SINEAluName=AluSz
ADediting_1334001chr7_44877680_-SINEAluName=AluSz
ADediting_1334002chr7_44877682_-SINEAluName=AluSz
ADediting_1334003chr7_44877692_-SINEAluName=AluSz
ADediting_1334004chr7_44877695_-SINEAluName=AluSz
ADediting_1334005chr7_44877717_-SINEAluName=AluSz
ADediting_1334006chr7_44877721_-SINEAluName=AluSz
ADediting_1334007chr7_44877741_-SINEAluName=AluSz
ADediting_1334008chr7_44877752_-SINEAluName=AluSz
ADediting_1334009chr7_44877807_-SINEAluName=AluSz
ADediting_1334010chr7_44879071_-SINEAluName=AluSg
ADediting_1334011chr7_44879073_-SINEAluName=AluSg
ADediting_1334012chr7_44879109_-SINEAluName=AluSg
ADediting_1334013chr7_44879129_-SINEAluName=AluSg
ADediting_1334014chr7_44879137_-SINEAluName=AluSg
ADediting_1334015chr7_44879169_-SINEAluName=AluSg
ADediting_1334016chr7_44879173_-SINEAluName=AluSg
ADediting_1334017chr7_44879179_-SINEAluName=AluSg
ADediting_1334018chr7_44879205_-SINEAluName=AluSg
ADediting_1334019chr7_44879214_-SINEAluName=AluSg
ADediting_1334020chr7_44879244_-SINEAluName=AluSg
ADediting_1334021chr7_44879294_-SINEAluName=AluSg
ADediting_1334022chr7_44879299_-SINEAluName=AluSg
ADediting_1334023chr7_44879300_-SINEAluName=AluSg
ADediting_1587637chr7_44877540_-SINEAluName=AluSz
ADediting_1587638chr7_44877722_-SINEAluName=AluSz
ADediting_1587639chr7_44879223_-SINEAluName=AluSg
ADediting_1587640chr7_44879234_-SINEAluName=AluSg
ADediting_1587641chr7_44879235_-SINEAluName=AluSg
ADediting_1587642chr7_44879236_-SINEAluName=AluSg

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RNA A-to-I editing events in the alternative splicing sites for PURB

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for PURB

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
Soverview
Soverview

check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

Soverview
Soverview
ADeditome IDChrPositoingSkipped exonENSGENSTs

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Protein coding region RNA A-to-I editings for PURB

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for PURB

check buttonRNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
all structure

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1333993chr7_44877557_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-383-3pchr744877552448775587mer-m84487755144877569140-16.64
ADediting_1333995chr7_44877559_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-204-3pchr744877558448775658mer-1a4487755844877577150-21.04
ADediting_1333995chr7_44877559_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-3192-5pchr744877558448775647mer-1a4487755844877580146-28.4
ADediting_1333995chr7_44877559_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-4314chr744877557448775648mer-1a4487755744877575151-16.77
ADediting_1333995chr7_44877559_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-4646-5pchr744877558448775658mer-1a4487755844877579159-27.87
ADediting_1334000chr7_44877679_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-6514-3pchr744877676448776827mer-m84487767544877696158-19.13
ADediting_1334002chr7_44877682_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-4327chr744877676448776838mer-1a4487767644877694140-13.38
ADediting_1334003chr7_44877692_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-3614-5pchr744877692448776987mer-m84487769144877714152-25.27
ADediting_1334003chr7_44877692_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-4691-3pchr744877688448776947mer-m84487768744877714150-26.36
ADediting_1334005chr7_44877717_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-589-5pchr744877712448777187mer-m84487771144877732156-16.87
ADediting_1334006chr7_44877721_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-6078chr744877717448777248mer-1a4487771744877735153-23.01
ADediting_1334006chr7_44877721_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-6751-3pchr744877721448777277mer-m84487772044877740141-13.02
ADediting_1334007chr7_44877741_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-17-3pchr744877741448777477mer-m84487774044877761150-16.39
ADediting_1334008chr7_44877752_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-4537chr744877747448777548mer-1a4487774744877769155-24.32
ADediting_1334011chr7_44879073_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-5691chr744879070448790778mer-1a4487907044879091145-18.94
ADediting_1334011chr7_44879073_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-6805-3pchr744879070448790778mer-1a4487907044879092158-21.15
ADediting_1334012chr7_44879109_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-4638-5pchr744879106448791138mer-1a4487910644879125146-20.28
ADediting_1334013chr7_44879129_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-1281chr744879126448791327mer-m84487912544879141145-17.85
ADediting_1334013chr7_44879129_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-660-3pchr744879128448791347mer-m84487912744879147164-21.31
ADediting_1334013chr7_44879129_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-6791-3pchr744879127448791337mer-m84487912644879145157-24.51
ADediting_1334013chr7_44879129_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-6829-3pchr744879127448791337mer-m84487912644879145144-20.88
ADediting_1334014chr7_44879137_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-10400-3pchr744879133448791397mer-m84487913244879153140-20.37
ADediting_1334014chr7_44879137_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-4437chr744879133448791408mer-1a4487913344879153145-16.69
ADediting_1334014chr7_44879137_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-4674chr744879133448791397mer-m84487913244879152146-23.01
ADediting_1334014chr7_44879137_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-6847-3pchr744879136448791427mer-m84487913544879156154-22.53
ADediting_1334015chr7_44879169_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-1207-3pchr744879169448791757mer-m84487916844879186145-13.53
ADediting_1334015chr7_44879169_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-646chr744879167448791737mer-m84487916644879185148-22.3
ADediting_1334017chr7_44879179_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-140-3pchr744879177448791837mer-m84487917644879196163-23.48
ADediting_1334019chr7_44879214_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-153-5pchr744879214448792207mer-m84487921344879235144-8.17
ADediting_1334020chr7_44879244_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-6876-3pchr744879242448792487mer-1a4487924244879265142-18.21
ADediting_1334021chr7_44879294_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-371a-3pchr744879289448792957mer-m84487928844879310145-16.11
ADediting_1334022chr7_44879299_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-8052chr744879294448793007mer-1a4487929444879312140-24.15
ADediting_1334023chr7_44879300_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-513a-5pchr744879299448793057mer-m84487929844879315144-16.68
ADediting_1334023chr7_44879300_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-638chr744879294448793007mer-1a4487929444879318159-35.77
ADediting_1334024chr7_44880792_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-34b-3pchr744880787448807937mer-m84488078644880807140-11.15
ADediting_1587639chr7_44879223_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-374b-3pchr744879218448792258mer-1a4487921844879240147-12.57
ADediting_1587640chr7_44879234_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-412-3pchr744879234448792407mer-m84487923344879260158-22.77
ADediting_1587640chr7_44879234_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-4508chr744879229448792357mer-m84487922844879244140-21.85
ADediting_1587640chr7_44879234_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-6754-3pchr744879234448792407mer-m84487923344879257145-17.32
ADediting_1587641chr7_44879235_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-1229-3pchr744879234448792407mer-m84487923344879254152-16.24
ADediting_1587641chr7_44879235_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-6511a-3pchr744879234448792418mer-1a4487923444879256147-17.85
ADediting_1587641chr7_44879235_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-6511b-3pchr744879234448792418mer-1a4487923444879257144-16.31
ADediting_1587642chr7_44879236_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-23a-5pchr744879231448792377mer-m84487923044879251140-18.3
ADediting_1587642chr7_44879236_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-23b-5pchr744879231448792377mer-m84487923044879250156-20.63

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1333993chr7_44877557_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-4310chr744877552448775587mer-m84487755144877566140-8.38
ADediting_1333993chr7_44877557_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-7157-5pchr744877552448775587mer-m84487755144877572151-15.94
ADediting_1333995chr7_44877559_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-450a-1-3pchr744877558448775658mer-1a4487755844877579140-10.65
ADediting_1333996chr7_44877637_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-4684-5pchr744877633448776397mer-m84487763244877654152-14.61
ADediting_1333999chr7_44877660_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-1285-3pchr744877659448776657mer-m84487765844877679140-15.26
ADediting_1333999chr7_44877660_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-3187-5pchr744877659448776657mer-m84487765844877681150-21.45
ADediting_1333999chr7_44877660_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-5189-5pchr744877659448776657mer-m84487765844877683149-23.98
ADediting_1333999chr7_44877660_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-612chr744877659448776657mer-m84487765844877683148-23.52
ADediting_1333999chr7_44877660_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-6860chr744877659448776657mer-m84487765844877680150-20.19
ADediting_1334003chr7_44877692_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-5690chr744877688448776947mer-m84487768744877707145-16.74
ADediting_1334004chr7_44877695_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-12126chr744877692448776998mer-1a4487769244877715147-13.23
ADediting_1334004chr7_44877695_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-887-5pchr744877695448777017mer-m84487769444877713143-19.73
ADediting_1334007chr7_44877741_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-12135chr744877736448777427mer-m84487773544877752140-9.26
ADediting_1334007chr7_44877741_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-6516-5pchr744877741448777477mer-m84487774044877759148-12.72
ADediting_1334009chr7_44877807_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-340-3pchr744877801448778088mer-1a4487780144877822146-18.22
ADediting_1334009chr7_44877807_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-371b-5pchr744877805448778128mer-1a4487780544877826146-8.27
ADediting_1334009chr7_44877807_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-373-5pchr744877805448778128mer-1a4487780544877826142-8.35
ADediting_1334009chr7_44877807_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-616-5pchr744877805448778128mer-1a4487780544877826140-5.71
ADediting_1334009chr7_44877807_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-6827-3pchr744877801448778088mer-1a4487780144877821140-14.67
ADediting_1334010chr7_44879071_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-6739-3pchr744879070448790767mer-m84487906944879089151-19.95
ADediting_1334011chr7_44879073_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-6739-3pchr744879070448790767mer-m84487906944879089151-19.95
ADediting_1334013chr7_44879129_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-516a-3pchr744879127448791337mer-m84487912644879146143-17.02
ADediting_1334013chr7_44879129_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-516b-3pchr744879127448791337mer-m84487912644879146143-17.02
ADediting_1334013chr7_44879129_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-7162-5pchr744879127448791337mer-m84487912644879143140-14.56
ADediting_1334014chr7_44879137_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-1206chr744879136448791427mer-m84487913544879155145-11.84
ADediting_1334015chr7_44879169_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-562chr744879166448791727mer-m84487916544879185151-14.2
ADediting_1334015chr7_44879169_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-5697chr744879165448791717mer-m84487916444879185146-18.01
ADediting_1334017chr7_44879179_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-7151-3pchr744879179448791857mer-m84487917844879199143-18.12
ADediting_1334017chr7_44879179_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-8052chr744879173448791797mer-1a4487917344879191143-23.66
ADediting_1334018chr7_44879205_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-4735-5pchr744879204448792107mer-m84487920344879224148-5.48
ADediting_1334018chr7_44879205_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-4775chr744879205448792117mer-m84487920444879226149-6.02
ADediting_1334020chr7_44879244_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-4716-5pchr744879239448792457mer-m84487923844879260146-15.79
ADediting_1334021chr7_44879294_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-5089-5pchr744879294448793007mer-m84487929344879315148-14.13
ADediting_1334021chr7_44879294_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-512-3pchr744879289448792957mer-m84487928844879309149-14.26
ADediting_1334021chr7_44879294_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-6506-5pchr744879293448792997mer-m84487929244879314144-13.78
ADediting_1334022chr7_44879299_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-10399-5pchr744879298448793047mer-m84487929744879318144-10.39
ADediting_1334022chr7_44879299_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-5089-5pchr744879294448793007mer-m84487929344879315148-14.13
ADediting_1334022chr7_44879299_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-6504-3pchr744879298448793047mer-m84487929744879318148-14.48
ADediting_1334023chr7_44879300_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-10399-5pchr744879298448793047mer-m84487929744879318144-10.39
ADediting_1334023chr7_44879300_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-6504-3pchr744879298448793047mer-m84487929744879318148-14.48
ADediting_1334023chr7_44879300_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-7151-3pchr744879299448793068mer-1a4487929944879319144-16.51
ADediting_1334025chr7_44881040_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-376c-3pchr744881037448810437mer-m84488103644881056153-13.52
ADediting_1587637chr7_44877540_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-6847-3pchr744877535448775417mer-m84487753444877557148-20.19
ADediting_1587639chr7_44879223_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-6832-5pchr744879222448792287mer-m84487922144879243142-16.66
ADediting_1587640chr7_44879234_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-193b-5pchr744879230448792367mer-m84487922944879250142-17.74
ADediting_1587641chr7_44879235_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-193b-5pchr744879230448792367mer-m84487922944879250142-17.74

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1097295chr3_85385762_+ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-5688chr744878199448782057mer-m84487819844878219150-12.23
ADediting_1097295chr3_85385762_+ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-5688chr744880235448802417mer-m84488023444880256156-14.83
ADediting_1337757chr7_5495852_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-589-3pchr744880108448801158mer-1a4488010844880133153-20.25
ADediting_1631458chr19_40282624_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-641chr744877126448771327mer-m84487712544877148146-16.17
ADediting_1631458chr19_40282624_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-641chr744882241448822477mer-m84488224044882263150-13.79
ADediting_286380chr11_79422188_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-5579-3pchr744878111448781177mer-1a4487811144878133140-20.44
ADediting_286380chr11_79422188_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-5579-3pchr744880425448804317mer-m84488042444880444153-16.3
ADediting_843620chr2_207754818_+ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-4775chr744880923448809308mer-1a4488092344880944160-11.79
ADediting_98289chr1_32086992_+ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-5585-3pchr744876644448766507mer-m84487664344876666154-21.26
ADediting_98289chr1_32086992_+ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-5585-3pchr744879484448794907mer-m84487948344879507143-16.84

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_107020chr1_37500952_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-5581-3pchr744883740448837478mer-1a4488374044883761140-13.14
ADediting_1097295chr3_85385762_+ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-5688chr744878020448780267mer-m84487801944878040144-9.57
ADediting_1097295chr3_85385762_+ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-5688chr744881138448811447mer-m84488113744881157152-11.48
ADediting_1097295chr3_85385762_+ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-5688chr744881508448815147mer-m84488150744881527143-9.57
ADediting_1535951chr14_100874558_+ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-337-3pchr744877199448772068mer-1a4487719944877220149-10.44
ADediting_1535953chr14_101045971_+ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-381-3pchr744882031448820388mer-1a4488203144882052142-11.15
ADediting_1535954chr14_101045974_+ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-381-3pchr744882031448820388mer-1a4488203144882052142-11.15
ADediting_1556067chr19_40282625_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-641chr744876989448769957mer-m84487698844877011149-14.04
ADediting_1556067chr19_40282625_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-641chr744878297448783037mer-m84487829644878318149-14.21
ADediting_1556067chr19_40282625_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-641chr744883718448837247mer-m84488371744883740143-13.38
ADediting_1631458chr19_40282624_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-641chr744876989448769957mer-m84487698844877011149-14.04
ADediting_1631458chr19_40282624_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-641chr744878297448783037mer-m84487829644878318149-14.21
ADediting_1631458chr19_40282624_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-641chr744883718448837247mer-m84488371744883740143-13.38
ADediting_286380chr11_79422188_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-5579-3pchr744881617448816237mer-m84488161644881637146-9.12
ADediting_286380chr11_79422188_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-5579-3pchr744881820448818267mer-m84488181944881839145-11.53
ADediting_291761chr11_93733708_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-1304-3pchr744880298448803058mer-1a4488029844880321142-18.6
ADediting_291761chr11_93733708_-ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-1304-3pchr744884327448843337mer-m84488432644884347140-11.07
ADediting_843620chr2_207754818_+ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-4775chr744879205448792117mer-m84487920444879226149-6.02
ADediting_843620chr2_207754818_+ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-4775chr744882527448825337mer-m84488252644882548155-10.09
ADediting_98288chr1_32086990_+ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-5585-3pchr744877150448771567mer-m84487714944877174154-19.25
ADediting_98288chr1_32086990_+ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-5585-3pchr744878240448782467mer-m84487823944878260140-13.8
ADediting_98289chr1_32086992_+ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-5585-3pchr744877150448771567mer-m84487714944877174154-19.25
ADediting_98289chr1_32086992_+ENSG00000146676.10ENST00000395699.5PURB-201hsa-miR-5585-3pchr744878240448782467mer-m84487823944878260140-13.8

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for PURB

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.
ENST00000395699.5protein_codingSoverviewSoverview

check button RNA A-to-I editing in miRNA.
ADeditom_IDENSTmir_IDEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in mRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI
ADediting_1587637ENST00000395699.5chr7_44877540_-7991-2966.50-2960.70-3026.20
ADediting_1333992ENST00000395699.5chr7_44877546_-7985-2960.70-2960.70-3026.20
ADediting_1333993ENST00000395699.5chr7_44877557_-7974-2966.50-2960.70-3026.20
ADediting_1333994ENST00000395699.5chr7_44877558_-7973-2962.10-2960.70-3026.20
ADediting_1333995ENST00000395699.5chr7_44877559_-7972-2966.70-2960.70-3026.20
ADediting_1333996ENST00000395699.5chr7_44877637_-7894-2960.40-2960.70-3026.20
ADediting_1333997ENST00000395699.5chr7_44877640_-7891-2960.40-2960.70-3026.20
ADediting_1333998ENST00000395699.5chr7_44877646_-7885-2960.70-2960.70-3026.20
ADediting_1333999ENST00000395699.5chr7_44877660_-7871-2966.90-2960.70-3026.20
ADediting_1334000ENST00000395699.5chr7_44877679_-7852-2967.30-2960.70-3026.20
ADediting_1334001ENST00000395699.5chr7_44877680_-7851-2960.00-2960.70-3026.20
ADediting_1334002ENST00000395699.5chr7_44877682_-7849-2960.70-2960.70-3026.20
ADediting_1334003ENST00000395699.5chr7_44877692_-7839-2960.40-2960.70-3026.20
ADediting_1334004ENST00000395699.5chr7_44877695_-7836-2960.40-2960.70-3026.20
ADediting_1334005ENST00000395699.5chr7_44877717_-7814-2961.00-2960.70-3026.20
ADediting_1334006ENST00000395699.5chr7_44877721_-7810-2960.70-2960.70-3026.20
ADediting_1587638ENST00000395699.5chr7_44877722_-7809-2960.60-2960.70-3026.20
ADediting_1334007ENST00000395699.5chr7_44877741_-7790-2960.70-2960.70-3026.20
ADediting_1334008ENST00000395699.5chr7_44877752_-7779-2964.30-2960.70-3026.20
ADediting_1334009ENST00000395699.5chr7_44877807_-7724-2959.80-2960.70-3026.20
ADediting_1334010ENST00000395699.5chr7_44879071_-6460-2966.70-2960.70-3026.20
ADediting_1334011ENST00000395699.5chr7_44879073_-6458-2967.40-2960.70-3026.20
ADediting_1334012ENST00000395699.5chr7_44879109_-6422-2964.10-2960.70-3026.20
ADediting_1334013ENST00000395699.5chr7_44879129_-6402-2967.30-2960.70-3026.20
ADediting_1334014ENST00000395699.5chr7_44879137_-6394-2967.40-2960.70-3026.20
ADediting_1334015ENST00000395699.5chr7_44879169_-6362-2960.70-2960.70-3026.20
ADediting_1334016ENST00000395699.5chr7_44879173_-6358-2960.00-2960.70-3026.20
ADediting_1334017ENST00000395699.5chr7_44879179_-6352-2960.30-2960.70-3026.20
ADediting_1334018ENST00000395699.5chr7_44879205_-6326-2960.40-2960.70-3026.20
ADediting_1334019ENST00000395699.5chr7_44879214_-6317-2960.70-2960.70-3026.20
ADediting_1587639ENST00000395699.5chr7_44879223_-6308-2960.70-2960.70-3026.20
ADediting_1587640ENST00000395699.5chr7_44879234_-6297-2960.70-2960.70-3026.20
ADediting_1587641ENST00000395699.5chr7_44879235_-6296-2960.80-2960.70-3026.20
ADediting_1587642ENST00000395699.5chr7_44879236_-6295-2960.20-2960.70-3026.20
ADediting_1334020ENST00000395699.5chr7_44879244_-6287-2960.70-2960.70-3026.20
ADediting_1334021ENST00000395699.5chr7_44879294_-6237-2960.00-2960.70-3026.20
ADediting_1334022ENST00000395699.5chr7_44879299_-6232-2960.70-2960.70-3026.20
ADediting_1334023ENST00000395699.5chr7_44879300_-6231-2960.80-2960.70-3026.20
ADediting_1334024ENST00000395699.5chr7_44880792_-4739-2966.90-2960.70-3026.20
ADediting_1334025ENST00000395699.5chr7_44881040_-4491-2966.60-2960.70-3026.20

check button RNA A-to-I editing in lncRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for PURB

check button Correlation between ADAR gene expression and RNA editing frequency
TissueADeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
CERADediting_1333992chr7_44877546_-0.1420330432266160.1204538034343670.0001447953580349420.3053653314912490.481773931042520.0578726054888424
CERADediting_1333996chr7_44877637_-0.001674645701517880.2544816825897588.10883430687751e-050.3161459300728630.4006697409584780.0691165535414416
CERADediting_1334000chr7_44877679_-0.008625848010486030.2137594343428872.81689001122847e-050.3348104919048820.004262765003472960.232103531592896
CERADediting_1334002chr7_44877682_-0.006931395328755890.2196032608526628.93279975286755e-050.3143749224118470.2263674346740440.0993638215668488
CERADediting_1334003chr7_44877692_-0.005814129934149040.2241979993377522.77612748973056e-050.3350595227758660.007224652227261280.218507038702147
CERADediting_1334007chr7_44877741_-0.01521131103921160.1978804396140841.96607172877768e-050.3408924439979540.0005355890759508420.279381714027089
CERADediting_1334008chr7_44877752_-0.02725732348211420.1802954913198925.99569500804983e-060.3601253534922734.12193635866874e-050.328229412027731
CERADediting_1334012chr7_44879109_-0.2418380030195840.09614591016400390.0001748177057850440.3017704298437880.0007637948090491640.271878746121173
CERADediting_1334013chr7_44879129_-0.1159823153385510.1288843765245164.47760611259086e-050.3267784959419750.01014002333360570.20934259428681
CERADediting_1334015chr7_44879169_-0.08258060652833540.1422044434780467.91918529126795e-050.3165773349561930.001134978465340170.263246927197611
CERADediting_1334017chr7_44879179_-0.01516941507426820.1979603711880363.7888420161739e-060.367235986217110.002441203251648460.24569322493886
CERADediting_1334018chr7_44879205_-0.006593363093788340.2209192395102855.92298204161062e-070.3943840040421930.003147976242280950.239586341047994

check button Correlation between ADAR gene expression and this gene's expression
TissueADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFC3.8733551743491e-280.5702916642443495.06302736986916e-110.3618418933162913.63638481812965e-220.51254563434309
AC3.96359841642414e-1180.9403562759987647.54626425819337e-930.9027732504667389.96272483207872e-070.303607737070108
PCC2.35078052559226e-860.9338972368512273.40919764743556e-820.9265708210514290.01231921329018320.180792926791319
CER6.78456749797535e-590.9112681606614991.56616303030333e-440.857356196431720.02326109718159990.185216157164081
TCX1.04197871360213e-630.9241067307662484.21871655893834e-230.6966333931434210.01518885771590730.197923253482504
FP3.84913257333706e-180.5909402464858025.08271736903437e-360.7688806940466570.4006421919196720.0633794128308958
IFG4.23713181034004e-080.8578513194658853.55749547050893e-060.7838956787618090.8011147559140590.0530620721347692
PG1.76296630801104e-560.8630877612013931.2226487144974e-400.7881464036445480.245111866097206-0.085644960960528
STG2.87029022657308e-160.7481559471028162.46800687230555e-220.8283038943867840.618231388633105-0.0551604574209271

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Relation with AD stages for PURB

check button Correlation between AD stages and RNA editing frequency
TissueADeditomIDpositionP-valCoeff.

check button Correlation between AD stages and this gene's expression
TissueP-valCoeff.
CER0.0002020816864676130.350287348043805
TCX0.0003933453198501460.338086177597392

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RelatedDrugs for PURB

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PURB

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource