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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for CASKIN1 |
 Gene summary |
| Gene information | Gene symbol | CASKIN1 | Gene ID | 57524 |
| Gene name | CASK interacting protein 1 | |
| Synonyms | ANKS5A | |
| Cytomap | 16p13.3 | |
| Type of gene | protein-coding | |
| Description | caskin-1 | |
| Modification date | 20200313 | |
| UniProtAcc | Q8WXD9, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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RNA A-to-I events for CASKIN1 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_523565(2192062, -), ADediting_523566(2192074, -), ADediting_523567(2192119, -), ADediting_523568(2192155, -), ADediting_523569(2192187, -), ADediting_523572(2192230, -), ADediting_523579(2193039, -), ADediting_523582(2193132, -), ADediting_523583(2193155, -), ADediting_523584(2193156, -), ADediting_523611(2196461, -), ADediting_1541399(2192088, -), |
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RNA editing positional annotations for CASKIN1 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_523565 | chr16_2192062_- | intronic |
| ADediting_523566 | chr16_2192074_- | intronic |
| ADediting_523567 | chr16_2192119_- | intronic |
| ADediting_523568 | chr16_2192155_- | intronic |
| ADediting_523569 | chr16_2192187_- | intronic |
| ADediting_523572 | chr16_2192230_- | intronic |
| ADediting_523579 | chr16_2193039_- | intronic |
| ADediting_523582 | chr16_2193132_- | intronic |
| ADediting_523583 | chr16_2193155_- | intronic |
| ADediting_523584 | chr16_2193156_- | intronic |
| ADediting_523611 | chr16_2196461_- | UTR5 |
| ADediting_1541399 | chr16_2192088_- | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_523565 | chr16_2192062_- | SINE | Alu | Name=AluJr |
| ADediting_523566 | chr16_2192074_- | SINE | Alu | Name=AluJr |
| ADediting_523567 | chr16_2192119_- | SINE | Alu | Name=AluJr |
| ADediting_523568 | chr16_2192155_- | SINE | Alu | Name=AluJr |
| ADediting_523569 | chr16_2192187_- | SINE | Alu | Name=AluJr |
| ADediting_523572 | chr16_2192230_- | SINE | Alu | Name=AluJr |
| ADediting_523579 | chr16_2193039_- | SINE | Alu | Name=AluSp |
| ADediting_523582 | chr16_2193132_- | SINE | Alu | Name=AluSp |
| ADediting_523583 | chr16_2193155_- | SINE | Alu | Name=AluSp |
| ADediting_523584 | chr16_2193156_- | SINE | Alu | Name=AluSp |
| ADediting_1541399 | chr16_2192088_- | SINE | Alu | Name=AluJr |
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RNA A-to-I editing events in the alternative splicing sites for CASKIN1 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for CASKIN1 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for CASKIN1 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for CASKIN1 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1337757 | chr7_5495852_- | ENSG00000167971.16 | ENST00000343516.8 | CASKIN1-201 | hsa-miR-589-3p | chr16 | 2177856 | 2177862 | 7mer-m8 | 2177855 | 2177881 | 161 | -35.48 |
| ADediting_496066 | chr15_66496985_- | ENSG00000167971.16 | ENST00000343516.8 | CASKIN1-201 | hsa-miR-4512 | chr16 | 2177903 | 2177910 | 8mer-1a | 2177903 | 2177923 | 154 | -24.74 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_286380 | chr11_79422188_- | ENSG00000167971.16 | ENST00000343516.8 | CASKIN1-201 | hsa-miR-5579-3p | chr16 | 2178123 | 2178129 | 7mer-m8 | 2178122 | 2178143 | 140 | -7.8 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for CASKIN1 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000343516.8 | protein_coding |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_523611 | ENST00000343516.8 | chr16_2196461_- | 145 | -2875.60 | -2869.40 | -2875.60 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for CASKIN1 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | ADediting_523566 | chr16_2192074_- | 0.089287340184698 | 0.0966706952643533 | 0.524108740023098 | 0.0363153417509612 | 5.96493647328705e-12 | 0.37773827549862 |
| CER | ADediting_523566 | chr16_2192074_- | 0.252846046941113 | 0.0939426737531152 | 0.000185163829161538 | 0.30066411640998 | 0.0231439940913006 | 0.18537098694768 |
| TCX | ADediting_523611 | chr16_2196461_- | 0.0265354924632169 | 0.181136413677188 | 0.000108339575681183 | 0.310810288876951 | 0.00136902564301465 | -0.259059311836735 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 4.25114842764749e-19 | 0.477950917961285 | 1.43654762555175e-18 | 0.471570114684736 | 5.39356392313701e-26 | 0.55082436481349 |
| PCC | 4.08065692015408e-14 | 0.511311535166977 | 5.38389915513922e-12 | 0.472131785958545 | 0.00207486883081361 | 0.221490296219184 |
| CER | 1.84104309877738e-05 | 0.341990126924593 | 9.25203585992697e-18 | 0.62696036750388 | 0.00016085918632623 | 0.303363803267956 |
| TCX | 2.55661489732136e-07 | 0.405918820313208 | 4.47627630145443e-16 | 0.600644332098117 | 0.00662186416580358 | -0.220805993616546 |
| FP | 2.74160767226794e-05 | 0.308806456655571 | 0.190935649876599 | 0.0984803330923838 | 1.9357456772608e-06 | 0.348013876810405 |
| IFG | 5.36360672723446e-05 | 0.717758275235563 | 3.42786995600581e-06 | 0.784669110301531 | 0.104926874837672 | 0.332007353185275 |
| STG | 9.5575289387068e-06 | 0.462288730186747 | 6.11475890158962e-05 | 0.42296996939189 | 0.0173390588845108 | 0.25905105139109 |
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Relation with AD stages for CASKIN1 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 5.08868196470239e-09 | 0.52586456434504 |
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RelatedDrugs for CASKIN1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CASKIN1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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