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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited versus non-edited samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with AD stages

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene


Gene summary for ZNF490

check button Gene summary
Gene informationGene symbol

ZNF490

Gene ID

57474

Gene namezinc finger protein 490
Synonyms-
Cytomap

19p13.2-p13.13

Type of geneprotein-coding
Descriptionzinc finger protein 490
Modification date20200313
UniProtAcc

Q9ULM2,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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RNA A-to-I events for ZNF490

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_710709(12576251, -), ADediting_710710(12576263, -), ADediting_710711(12576326, -), ADediting_710712(12576340, -), ADediting_710713(12576343, -), ADediting_710714(12576358, -), ADediting_710715(12576366, -), ADediting_710716(12576384, -), ADediting_710717(12576394, -), ADediting_710718(12576406, -), ADediting_710719(12576419, -), ADediting_710720(12576420, -), ADediting_710721(12576423, -), ADediting_710722(12576479, -), ADediting_710723(12576558, -), ADediting_710724(12576570, -), ADediting_710725(12576634, -), ADediting_710726(12576651, -), ADediting_710727(12576705, -), ADediting_710728(12576730, -), ADediting_710729(12576731, -), ADediting_710730(12576734, -), ADediting_710731(12576735, -), ADediting_710732(12576748, -), ADediting_710733(12576754, -), ADediting_710734(12576755, -), ADediting_710735(12576760, -), ADediting_710736(12576770, -), ADediting_710737(12576771, -), ADediting_710738(12576773, -), ADediting_710739(12579064, -), ADediting_710740(12579201, -), ADediting_710741(12579429, -), ADediting_710742(12579608, -), ADediting_710743(12579686, -), ADediting_710744(12579689, -), ADediting_710745(12579703, -), ADediting_710746(12589274, -), ADediting_710747(12589275, -), ADediting_710748(12590187, -), ADediting_710749(12590188, -), ADediting_710750(12590292, -), ADediting_710751(12590328, -), ADediting_710752(12590436, -), ADediting_710753(12590443, -), ADediting_710754(12590482, -), ADediting_710755(12590494, -), ADediting_710756(12590495, -), ADediting_710757(12590517, -), ADediting_710758(12591132, -), ADediting_710759(12591186, -), ADediting_710760(12591197, -), ADediting_710761(12591289, -), ADediting_710762(12591294, -), ADediting_710763(12591307, -), ADediting_710764(12591314, -), ADediting_710765(12591333, -), ADediting_710766(12591357, -), ADediting_710767(12591368, -), ADediting_710768(12593359, -), ADediting_710769(12593376, -), ADediting_710770(12594371, -), ADediting_710771(12595380, -), ADediting_710772(12595385, -), ADediting_710773(12595787, -), ADediting_710774(12598471, -), ADediting_710775(12598472, -), ADediting_710776(12598513, -), ADediting_710777(12598539, -), ADediting_710778(12598553, -), ADediting_710779(12598744, -), ADediting_710780(12598911, -), ADediting_710781(12602467, -), ADediting_710782(12602487, -), ADediting_710783(12602697, -), ADediting_710784(12602698, -), ADediting_710785(12602708, -), ADediting_710786(12602730, -), ADediting_710787(12602763, -), ADediting_710788(12602853, -), ADediting_710789(12602872, -), ADediting_710790(12602898, -), ADediting_710791(12602899, -), ADediting_710792(12603386, -), ADediting_710793(12604281, -), ADediting_710794(12604298, -), ADediting_710795(12604323, -), ADediting_710796(12604897, -), ADediting_710797(12604936, -), ADediting_710798(12604974, -), ADediting_710799(12605031, -), ADediting_710800(12605069, -), ADediting_710801(12605070, -), ADediting_710802(12605090, -), ADediting_710803(12605109, -), ADediting_710804(12605112, -), ADediting_710805(12605977, -), ADediting_710806(12606271, -), ADediting_710807(12606509, -), ADediting_710808(12606563, -), ADediting_710809(12608608, -), ADediting_710810(12608679, -), ADediting_710811(12608680, -), ADediting_710812(12608747, -), ADediting_710813(12608748, -), ADediting_710814(12608761, -), ADediting_710815(12608764, -), ADediting_710816(12608856, -), ADediting_710817(12635557, -), ADediting_710818(12635586, -), ADediting_710819(12635598, -), ADediting_710820(12636294, -), ADediting_710821(12637079, -), ADediting_710822(12638409, -), ADediting_710823(12638415, -), ADediting_710824(12639143, -), ADediting_710825(12639156, -), ADediting_710826(12639336, -), ADediting_1552352(12576349, -), ADediting_1552353(12576459, -), ADediting_1552354(12576468, -), ADediting_1552355(12579439, -), ADediting_1552356(12634673, -), ADediting_1552357(12635095, -), ADediting_1630821(12591267, -), ADediting_1630822(12595392, -), ADediting_1630823(12634759, -),

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RNA editing positional annotations for ZNF490 using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_710709chr19_12576251_-UTR3
ADediting_710710chr19_12576263_-UTR3
ADediting_710711chr19_12576326_-UTR3
ADediting_710712chr19_12576340_-UTR3
ADediting_710713chr19_12576343_-UTR3
ADediting_710714chr19_12576358_-UTR3
ADediting_710715chr19_12576366_-UTR3
ADediting_710716chr19_12576384_-UTR3
ADediting_710717chr19_12576394_-UTR3
ADediting_710718chr19_12576406_-UTR3
ADediting_710719chr19_12576419_-UTR3
ADediting_710720chr19_12576420_-UTR3
ADediting_710721chr19_12576423_-UTR3
ADediting_710722chr19_12576479_-UTR3
ADediting_710723chr19_12576558_-UTR3
ADediting_710724chr19_12576570_-UTR3
ADediting_710725chr19_12576634_-UTR3
ADediting_710726chr19_12576651_-UTR3
ADediting_710727chr19_12576705_-UTR3
ADediting_710728chr19_12576730_-UTR3
ADediting_710729chr19_12576731_-UTR3
ADediting_710730chr19_12576734_-UTR3
ADediting_710731chr19_12576735_-UTR3
ADediting_710732chr19_12576748_-UTR3
ADediting_710733chr19_12576754_-UTR3
ADediting_710734chr19_12576755_-UTR3
ADediting_710735chr19_12576760_-UTR3
ADediting_710736chr19_12576770_-UTR3
ADediting_710737chr19_12576771_-UTR3
ADediting_710738chr19_12576773_-UTR3
ADediting_710739chr19_12579064_-UTR3
ADediting_710740chr19_12579201_-UTR3
ADediting_710741chr19_12579429_-UTR3
ADediting_710742chr19_12579608_-UTR3
ADediting_710743chr19_12579686_-UTR3
ADediting_710744chr19_12579689_-UTR3
ADediting_710745chr19_12579703_-UTR3
ADediting_710746chr19_12589274_-intronic
ADediting_710747chr19_12589275_-intronic
ADediting_710748chr19_12590187_-intronic
ADediting_710749chr19_12590188_-intronic
ADediting_710750chr19_12590292_-intronic
ADediting_710751chr19_12590328_-intronic
ADediting_710752chr19_12590436_-intronic
ADediting_710753chr19_12590443_-intronic
ADediting_710754chr19_12590482_-intronic
ADediting_710755chr19_12590494_-intronic
ADediting_710756chr19_12590495_-intronic
ADediting_710757chr19_12590517_-intronic
ADediting_710758chr19_12591132_-intronic
ADediting_710759chr19_12591186_-intronic
ADediting_710760chr19_12591197_-intronic
ADediting_710761chr19_12591289_-intronic
ADediting_710762chr19_12591294_-intronic
ADediting_710763chr19_12591307_-intronic
ADediting_710764chr19_12591314_-intronic
ADediting_710765chr19_12591333_-intronic
ADediting_710766chr19_12591357_-intronic
ADediting_710767chr19_12591368_-intronic
ADediting_710768chr19_12593359_-intronic
ADediting_710769chr19_12593376_-intronic
ADediting_710770chr19_12594371_-intronic
ADediting_710771chr19_12595380_-intronic
ADediting_710772chr19_12595385_-intronic
ADediting_710773chr19_12595787_-intronic
ADediting_710774chr19_12598471_-intronic
ADediting_710775chr19_12598472_-intronic
ADediting_710776chr19_12598513_-intronic
ADediting_710777chr19_12598539_-intronic
ADediting_710778chr19_12598553_-intronic
ADediting_710779chr19_12598744_-intronic
ADediting_710780chr19_12598911_-intronic
ADediting_710781chr19_12602467_-intronic
ADediting_710782chr19_12602487_-intronic
ADediting_710783chr19_12602697_-intronic
ADediting_710784chr19_12602698_-intronic
ADediting_710785chr19_12602708_-intronic
ADediting_710786chr19_12602730_-intronic
ADediting_710787chr19_12602763_-intronic
ADediting_710788chr19_12602853_-intronic
ADediting_710789chr19_12602872_-intronic
ADediting_710790chr19_12602898_-intronic
ADediting_710791chr19_12602899_-intronic
ADediting_710792chr19_12603386_-intronic
ADediting_710793chr19_12604281_-intronic
ADediting_710794chr19_12604298_-intronic
ADediting_710795chr19_12604323_-intronic
ADediting_710796chr19_12604897_-intronic
ADediting_710797chr19_12604936_-intronic
ADediting_710798chr19_12604974_-intronic
ADediting_710799chr19_12605031_-intronic
ADediting_710800chr19_12605069_-intronic
ADediting_710801chr19_12605070_-intronic
ADediting_710802chr19_12605090_-intronic
ADediting_710803chr19_12605109_-intronic
ADediting_710804chr19_12605112_-intronic
ADediting_710805chr19_12605977_-intronic
ADediting_710806chr19_12606271_-intronic
ADediting_710807chr19_12606509_-intronic
ADediting_710808chr19_12606563_-intronic
ADediting_710809chr19_12608608_-intronic
ADediting_710810chr19_12608679_-intronic
ADediting_710811chr19_12608680_-intronic
ADediting_710812chr19_12608747_-intronic
ADediting_710813chr19_12608748_-intronic
ADediting_710814chr19_12608761_-intronic
ADediting_710815chr19_12608764_-intronic
ADediting_710816chr19_12608856_-intronic
ADediting_710817chr19_12635557_-intergenic
ADediting_710818chr19_12635586_-intergenic
ADediting_710819chr19_12635598_-intergenic
ADediting_710820chr19_12636294_-intergenic
ADediting_710821chr19_12637079_-intergenic
ADediting_710822chr19_12638409_-intergenic
ADediting_710823chr19_12638415_-intergenic
ADediting_710824chr19_12639143_-intergenic
ADediting_710825chr19_12639156_-intergenic
ADediting_710826chr19_12639336_-intergenic
ADediting_1552352chr19_12576349_-UTR3
ADediting_1552353chr19_12576459_-UTR3
ADediting_1552354chr19_12576468_-UTR3
ADediting_1552355chr19_12579439_-UTR3
ADediting_1552356chr19_12634673_-downstream
ADediting_1552357chr19_12635095_-intergenic
ADediting_1630821chr19_12591267_-intronic
ADediting_1630822chr19_12595392_-intronic
ADediting_1630823chr19_12634759_-downstream

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_710709chr19_12576251_-SINEAluName=AluSc
ADediting_710710chr19_12576263_-SINEAluName=AluSc
ADediting_710711chr19_12576326_-SINEAluName=AluSc
ADediting_710712chr19_12576340_-SINEAluName=AluSc
ADediting_710713chr19_12576343_-SINEAluName=AluSc
ADediting_710714chr19_12576358_-SINEAluName=AluSc
ADediting_710715chr19_12576366_-SINEAluName=AluSc
ADediting_710716chr19_12576384_-SINEAluName=AluSc
ADediting_710717chr19_12576394_-SINEAluName=AluSc
ADediting_710718chr19_12576406_-SINEAluName=AluSc
ADediting_710719chr19_12576419_-SINEAluName=AluSc
ADediting_710720chr19_12576420_-SINEAluName=AluSc
ADediting_710721chr19_12576423_-SINEAluName=AluSc
ADediting_710722chr19_12576479_-SINEAluName=AluSc
ADediting_710723chr19_12576558_-SINEAluName=AluSc
ADediting_710724chr19_12576570_-SINEAluName=AluSc
ADediting_710725chr19_12576634_-SINEAluName=AluSc
ADediting_710726chr19_12576651_-SINEAluName=AluSc
ADediting_710727chr19_12576705_-SINEAluName=AluSc
ADediting_710728chr19_12576730_-SINEAluName=AluSc
ADediting_710729chr19_12576731_-SINEAluName=AluSc
ADediting_710730chr19_12576734_-SINEAluName=AluSc
ADediting_710731chr19_12576735_-SINEAluName=AluSc
ADediting_710732chr19_12576748_-SINEAluName=AluSc
ADediting_710733chr19_12576754_-SINEAluName=AluSc
ADediting_710734chr19_12576755_-SINEAluName=AluSc
ADediting_710735chr19_12576760_-SINEAluName=AluSc
ADediting_710736chr19_12576770_-SINEAluName=AluSc
ADediting_710737chr19_12576771_-SINEAluName=AluSc
ADediting_710738chr19_12576773_-SINEAluName=AluSc
ADediting_710739chr19_12579064_-SINEAluName=AluY
ADediting_710740chr19_12579201_-SINEAluName=AluY
ADediting_710741chr19_12579429_-SINEAluName=AluSx
ADediting_710742chr19_12579608_-SINEAluName=AluSx1
ADediting_710743chr19_12579686_-SINEAluName=AluSx1
ADediting_710744chr19_12579689_-SINEAluName=AluSx1
ADediting_710745chr19_12579703_-SINEAluName=AluSx1
ADediting_710746chr19_12589274_-SINEAluName=AluSx
ADediting_710747chr19_12589275_-SINEAluName=AluSx
ADediting_710748chr19_12590187_-SINEAluName=AluSx3
ADediting_710749chr19_12590188_-SINEAluName=AluSx3
ADediting_710750chr19_12590292_-SINEAluName=AluSz
ADediting_710751chr19_12590328_-SINEAluName=AluSz
ADediting_710752chr19_12590436_-SINEAluName=AluSz
ADediting_710753chr19_12590443_-SINEAluName=AluSz
ADediting_710754chr19_12590482_-SINEAluName=AluSz
ADediting_710755chr19_12590494_-SINEAluName=AluSz
ADediting_710756chr19_12590495_-SINEAluName=AluSz
ADediting_710757chr19_12590517_-SINEAluName=AluSz
ADediting_710758chr19_12591132_-SINEAluName=AluSz
ADediting_710759chr19_12591186_-SINEAluName=AluSz
ADediting_710760chr19_12591197_-SINEAluName=AluSz
ADediting_710761chr19_12591289_-SINEAluName=AluSz
ADediting_710762chr19_12591294_-SINEAluName=AluSz
ADediting_710763chr19_12591307_-SINEAluName=AluSz
ADediting_710764chr19_12591314_-SINEAluName=AluSz
ADediting_710765chr19_12591333_-SINEAluName=AluSz
ADediting_710766chr19_12591357_-SINEAluName=AluSz
ADediting_710767chr19_12591368_-SINEAluName=AluSz
ADediting_710768chr19_12593359_-SINEAluName=AluSz
ADediting_710769chr19_12593376_-SINEAluName=AluSz
ADediting_710770chr19_12594371_-SINEAluName=AluSz
ADediting_710771chr19_12595380_-SINEAluName=AluSp
ADediting_710772chr19_12595385_-SINEAluName=AluSp
ADediting_710773chr19_12595787_-SINEAluName=AluSx1
ADediting_710774chr19_12598471_-SINEAluName=AluSp
ADediting_710775chr19_12598472_-SINEAluName=AluSp
ADediting_710776chr19_12598513_-SINEAluName=AluSp
ADediting_710777chr19_12598539_-SINEAluName=AluSp
ADediting_710778chr19_12598553_-SINEAluName=AluSp
ADediting_710779chr19_12598744_-SINEAluName=AluSg
ADediting_710780chr19_12598911_-SINEAluName=AluSg
ADediting_710781chr19_12602467_-SINEAluName=AluSx1
ADediting_710782chr19_12602487_-SINEAluName=AluSx1
ADediting_710783chr19_12602697_-SINEAluName=AluJb
ADediting_710784chr19_12602698_-SINEAluName=AluJb
ADediting_710785chr19_12602708_-SINEAluName=AluJb
ADediting_710786chr19_12602730_-SINEAluName=AluJb
ADediting_710787chr19_12602763_-SINEAluName=AluJb
ADediting_710788chr19_12602853_-SINEAluName=AluJb
ADediting_710789chr19_12602872_-SINEAluName=AluJb
ADediting_710790chr19_12602898_-SINEAluName=AluJb
ADediting_710791chr19_12602899_-SINEAluName=AluJb
ADediting_710792chr19_12603386_-SINEAluName=AluJo
ADediting_710793chr19_12604281_-SINEAluName=AluSq2
ADediting_710794chr19_12604298_-SINEAluName=AluSq2
ADediting_710795chr19_12604323_-SINEAluName=AluSq2
ADediting_710796chr19_12604897_-SINEAluName=AluSx1
ADediting_710797chr19_12604936_-SINEAluName=AluSx1
ADediting_710798chr19_12604974_-SINEAluName=AluSx1
ADediting_710799chr19_12605031_-SINEAluName=AluSx1
ADediting_710800chr19_12605069_-SINEAluName=AluSx1
ADediting_710801chr19_12605070_-SINEAluName=AluSx1
ADediting_710802chr19_12605090_-SINEAluName=AluSx1
ADediting_710803chr19_12605109_-SINEAluName=AluSx1
ADediting_710804chr19_12605112_-SINEAluName=AluSx1
ADediting_710805chr19_12605977_-SINEAluName=AluSp
ADediting_710806chr19_12606271_-SINEAluName=AluJo
ADediting_710807chr19_12606509_-SINEAluName=AluSz
ADediting_710808chr19_12606563_-SINEAluName=AluSz
ADediting_710809chr19_12608608_-SINEAluName=AluSz6
ADediting_710810chr19_12608679_-SINEAluName=AluSz6
ADediting_710811chr19_12608680_-SINEAluName=AluSz6
ADediting_710812chr19_12608747_-SINEAluName=AluSz6
ADediting_710813chr19_12608748_-SINEAluName=AluSz6
ADediting_710814chr19_12608761_-SINEAluName=AluSz6
ADediting_710815chr19_12608764_-SINEAluName=AluSz6
ADediting_710816chr19_12608856_-SINEAluName=AluJr
ADediting_710817chr19_12635557_-SINEAluName=AluJr
ADediting_710818chr19_12635586_-SINEAluName=AluJr
ADediting_710819chr19_12635598_-SINEAluName=AluJr
ADediting_710820chr19_12636294_-SINEAluName=AluSx1
ADediting_710821chr19_12637079_-SINEAluName=AluSq2
ADediting_710822chr19_12638409_-SINEAluName=AluY
ADediting_710823chr19_12638415_-SINEAluName=AluY
ADediting_710824chr19_12639143_-SINEAluName=AluSx1
ADediting_710825chr19_12639156_-SINEAluName=AluSx1
ADediting_710826chr19_12639336_-SINEAluName=AluY
ADediting_1552352chr19_12576349_-SINEAluName=AluSc
ADediting_1552353chr19_12576459_-SINEAluName=AluSc
ADediting_1552354chr19_12576468_-SINEAluName=AluSc
ADediting_1552355chr19_12579439_-SINEAluName=AluSx
ADediting_1552356chr19_12634673_-SINEAluName=AluSx
ADediting_1552357chr19_12635095_-SINEAluName=AluJr4
ADediting_1630821chr19_12591267_-SINEAluName=AluSz
ADediting_1630822chr19_12595392_-SINEAluName=AluSp
ADediting_1630823chr19_12634759_-SINEAluName=AluSx

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RNA A-to-I editing events in the alternative splicing sites for ZNF490

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for ZNF490

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

Soverview
Soverview
ADeditome IDChrPositoingSkipped exonENSGENSTs

Top

Protein coding region RNA A-to-I editings for ZNF490

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


Top

The effects of the RNA editing to the miRNA binding sites for ZNF490

check buttonRNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
all structure

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1552352chr19_12576349_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-3613-3pchr1912576349125763557mer-m81257634812576371156-10.63
ADediting_1552353chr19_12576459_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-4786-5pchr1912576455125764617mer-m81257645412576478154-21.73
ADediting_1552353chr19_12576459_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-591chr1912576457125764637mer-m81257645612576475140-18.78
ADediting_1552353chr19_12576459_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-6502-3pchr1912576456125764627mer-m81257645512576475155-13.87
ADediting_1552353chr19_12576459_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-6872-3pchr1912576459125764657mer-m81257645812576477150-21.89
ADediting_1552355chr19_12579439_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-4691-3pchr1912579435125794417mer-m81257943412579461147-26.14
ADediting_710714chr19_12576358_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-4267chr1912576357125763637mer-m81257635612576371156-23.9
ADediting_710714chr19_12576358_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-548aachr1912576353125763597mer-m81257635212576378142-10.05
ADediting_710714chr19_12576358_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-548ap-3pchr1912576353125763597mer-m81257635212576370140-7.26
ADediting_710714chr19_12576358_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-548t-3pchr1912576353125763597mer-m81257635212576378142-10.05
ADediting_710715chr19_12576366_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-3622b-5pchr1912576364125763707mer-m81257636312576380142-22.33
ADediting_710715chr19_12576366_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-4304chr1912576362125763698mer-1a1257636212576378140-17.43
ADediting_710717chr19_12576394_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-4691-3pchr1912576390125763967mer-m81257638912576416151-24.96
ADediting_710718chr19_12576406_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-6089chr1912576401125764077mer-m81257640012576423156-33.27
ADediting_710719chr19_12576419_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-146a-5pchr1912576414125764207mer-m81257641312576435151-22.31
ADediting_710719chr19_12576419_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-146b-5pchr1912576414125764207mer-m81257641312576435145-15.82
ADediting_710719chr19_12576419_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-7153-5pchr1912576414125764207mer-m81257641312576436152-22
ADediting_710722chr19_12576479_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-4299chr1912576479125764857mer-m81257647812576494158-21.81
ADediting_710722chr19_12576479_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-6849-3pchr1912576473125764808mer-1a1257647312576495148-18.33
ADediting_710724chr19_12576570_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-3189-3pchr1912576569125765757mer-m81257656812576588151-22.51
ADediting_710724chr19_12576570_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-6813-3pchr1912576568125765747mer-m81257656712576587140-11.58
ADediting_710727chr19_12576705_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-4691-3pchr1912576701125767077mer-m81257670012576727150-26.36
ADediting_710728chr19_12576730_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-146a-5pchr1912576725125767317mer-m81257672412576746147-19.24
ADediting_710728chr19_12576730_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-146b-5pchr1912576725125767317mer-m81257672412576746145-15.36
ADediting_710728chr19_12576730_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-7153-5pchr1912576725125767317mer-m81257672412576747148-17.27
ADediting_710732chr19_12576748_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-658chr1912576747125767537mer-m81257674612576772153-26.62
ADediting_710732chr19_12576748_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-7846-3pchr1912576746125767527mer-m81257674512576765158-18.44
ADediting_710733chr19_12576754_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-17-3pchr1912576754125767607mer-m81257675312576775157-20.02
ADediting_710733chr19_12576754_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-485-5pchr1912576750125767567mer-m81257674912576769153-17.86
ADediting_710733chr19_12576754_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-6884-5pchr1912576750125767567mer-m81257674912576771146-20.16
ADediting_710736chr19_12576770_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-6529-3pchr1912576770125767767mer-m81257676912576791156-18.52
ADediting_710736chr19_12576770_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-6889-3pchr1912576770125767767mer-m81257676912576789156-22.5
ADediting_710739chr19_12579064_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-3190-5pchr1912579059125790657mer-m81257905812579076152-22.63
ADediting_710739chr19_12579064_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-548schr1912579060125790667mer-m81257905912579081149-13.99
ADediting_710740chr19_12579201_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-4537chr1912579196125792038mer-1a1257919612579218151-25.93
ADediting_710741chr19_12579429_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-106a-3pchr1912579427125794337mer-m81257942612579448159-19.83
ADediting_710742chr19_12579608_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-520e-5pchr1912579606125796138mer-1a1257960612579627140-11.69
ADediting_710743chr19_12579686_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-6804-3pchr1912579682125796887mer-m81257968112579703155-18.21
ADediting_710745chr19_12579703_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-6125chr1912579702125797098mer-1a1257970212579722159-26.5

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1552354chr19_12576468_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-17-3pchr1912576467125764737mer-m81257646612576484147-17.7
ADediting_1552354chr19_12576468_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-324-3pchr1912576464125764707mer-m81257646312576488149-21.37
ADediting_1552354chr19_12576468_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-4418chr1912576466125764727mer-m81257646512576480145-23.12
ADediting_1552354chr19_12576468_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-509-3-5pchr1912576466125764727mer-m81257646512576485145-19.51
ADediting_1552354chr19_12576468_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-509-5pchr1912576466125764727mer-m81257646512576488145-19.95
ADediting_1552355chr19_12579439_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-5690chr1912579435125794417mer-m81257943412579454150-16.48
ADediting_710712chr19_12576340_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-4684-5pchr1912576336125763427mer-m81257633512576356151-12.03
ADediting_710714chr19_12576358_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-4661-5pchr1912576356125763627mer-m81257635512576376153-19.37
ADediting_710715chr19_12576366_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-4798-5pchr1912576362125763687mer-m81257636112576382140-15.71
ADediting_710715chr19_12576366_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-8088chr1912576361125763677mer-m81257636012576379146-18.48
ADediting_710717chr19_12576394_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-5690chr1912576390125763967mer-m81257638912576409145-17.72
ADediting_710718chr19_12576406_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-3929chr1912576402125764087mer-m81257640112576422152-17.74
ADediting_710718chr19_12576406_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-4478chr1912576402125764087mer-m81257640112576416145-23.3
ADediting_710718chr19_12576406_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-485-5pchr1912576401125764077mer-m81257640012576421153-20.12
ADediting_710719chr19_12576419_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-219b-3pchr1912576416125764227mer-m81257641512576435153-15.53
ADediting_710719chr19_12576419_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-302fchr1912576417125764237mer-m81257641612576432147-8.32
ADediting_710720chr19_12576420_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-219b-3pchr1912576416125764227mer-m81257641512576435153-15.53
ADediting_710720chr19_12576420_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-302fchr1912576417125764237mer-m81257641612576432147-8.32
ADediting_710722chr19_12576479_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-4453chr1912576476125764827mer-m81257647512576495153-18.11
ADediting_710727chr19_12576705_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-5690chr1912576701125767077mer-m81257670012576720145-17.72
ADediting_710728chr19_12576730_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-219b-3pchr1912576727125767337mer-m81257672612576746153-15.53
ADediting_710728chr19_12576730_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-302fchr1912576728125767347mer-m81257672712576743147-8.79
ADediting_710729chr19_12576731_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-219b-3pchr1912576727125767337mer-m81257672612576746153-15.53
ADediting_710729chr19_12576731_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-302fchr1912576728125767347mer-m81257672712576743147-8.79
ADediting_710732chr19_12576748_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-12117chr1912576745125767517mer-m81257674412576763145-23.8
ADediting_710732chr19_12576748_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-4795-5pchr1912576744125767507mer-m81257674312576763140-12.95
ADediting_710732chr19_12576748_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-7847-3pchr1912576747125767537mer-m81257674612576768146-18.89
ADediting_710733chr19_12576754_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-377-5pchr1912576750125767567mer-m81257674912576770155-17.55
ADediting_710733chr19_12576754_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-6086chr1912576750125767567mer-m81257674912576768148-21.93
ADediting_710733chr19_12576754_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-6516-5pchr1912576754125767607mer-m81257675312576778152-16.76
ADediting_710734chr19_12576755_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-377-5pchr1912576750125767567mer-m81257674912576770155-17.55
ADediting_710734chr19_12576755_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-6086chr1912576750125767567mer-m81257674912576768148-21.93
ADediting_710734chr19_12576755_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-6516-5pchr1912576754125767607mer-m81257675312576778152-16.76
ADediting_710735chr19_12576760_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-6807-5pchr1912576760125767667mer-m81257675912576778145-17.12
ADediting_710738chr19_12576773_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-1227-3pchr1912576771125767788mer-1a1257677112576790148-18.2
ADediting_710739chr19_12579064_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-4794chr1912579059125790657mer-m81257905812579080151-21.79
ADediting_710739chr19_12579064_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-664a-5pchr1912579059125790657mer-m81257905812579081141-16.08
ADediting_710740chr19_12579201_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-3160-3pchr1912579196125792038mer-1a1257919612579217150-20.6
ADediting_710743chr19_12579686_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-6500-3pchr1912579683125796897mer-m81257968212579702140-13.41
ADediting_710745chr19_12579703_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-890chr1912579699125797068mer-1a1257969912579717154-18.35

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1337757chr7_5495852_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-589-3pchr1912578448125784547mer-1a1257844812578471142-26.37
ADediting_1535951chr14_100874558_+ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-337-3pchr1912577298125773058mer-1a1257729812577323149-19.39
ADediting_1535953chr14_101045971_+ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-381-3pchr1912576213125762197mer-m81257621212576235143-13.11
ADediting_1535954chr14_101045974_+ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-381-3pchr1912576931125769377mer-m81257693012576953148-15.95
ADediting_1535954chr14_101045974_+ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-381-3pchr1912578418125784247mer-m81257841712578436148-14.86
ADediting_496066chr15_66496985_-ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-4512chr1912579445125794517mer-m81257944412579467150-15.03

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1097295chr3_85385762_+ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-5688chr1912576513125765197mer-m81257651212576534154-12.91
ADediting_1097295chr3_85385762_+ENSG00000188033.10ENST00000311437.11ZNF490-201hsa-miR-5688chr1912576517125765237mer-m81257651212576534154-12.91

check button Differentially expressed gene-miRNA network

Top

The effects of the RNA editing to the stability of the RNA structures for ZNF490

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.
ENST00000311437.11protein_codingSoverviewSoverview

check button RNA A-to-I editing in miRNA.
ADeditom_IDENSTmir_IDEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in mRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI
ADediting_710709ENST00000311437.11chr19_12576251_-5957-1925.30-1921.80-1985.00
ADediting_710710ENST00000311437.11chr19_12576263_-5945-1923.70-1921.80-1985.00
ADediting_710711ENST00000311437.11chr19_12576326_-5882-1925.20-1921.80-1985.00
ADediting_710712ENST00000311437.11chr19_12576340_-5868-1923.50-1921.80-1985.00
ADediting_710713ENST00000311437.11chr19_12576343_-5865-1925.30-1921.80-1985.00
ADediting_1552352ENST00000311437.11chr19_12576349_-5859-1921.80-1921.80-1985.00
ADediting_710714ENST00000311437.11chr19_12576358_-5850-1923.20-1921.80-1985.00
ADediting_710715ENST00000311437.11chr19_12576366_-5842-1923.30-1921.80-1985.00
ADediting_710716ENST00000311437.11chr19_12576384_-5824-1924.50-1921.80-1985.00
ADediting_710717ENST00000311437.11chr19_12576394_-5814-1923.70-1921.80-1985.00
ADediting_710718ENST00000311437.11chr19_12576406_-5802-1921.70-1921.80-1985.00
ADediting_710719ENST00000311437.11chr19_12576419_-5789-1924.70-1921.80-1985.00
ADediting_710720ENST00000311437.11chr19_12576420_-5788-1921.10-1921.80-1985.00
ADediting_710721ENST00000311437.11chr19_12576423_-5785-1922.50-1921.80-1985.00
ADediting_1552353ENST00000311437.11chr19_12576459_-5749-1923.60-1921.80-1985.00
ADediting_1552354ENST00000311437.11chr19_12576468_-5740-1921.40-1921.80-1985.00
ADediting_710722ENST00000311437.11chr19_12576479_-5729-1923.10-1921.80-1985.00
ADediting_710723ENST00000311437.11chr19_12576558_-5650-1921.60-1921.80-1985.00
ADediting_710724ENST00000311437.11chr19_12576570_-5638-1928.00-1921.80-1985.00
ADediting_710725ENST00000311437.11chr19_12576634_-5574-1922.00-1921.80-1985.00
ADediting_710726ENST00000311437.11chr19_12576651_-5557-1925.20-1921.80-1985.00
ADediting_710727ENST00000311437.11chr19_12576705_-5503-1923.00-1921.80-1985.00
ADediting_710728ENST00000311437.11chr19_12576730_-5478-1923.30-1921.80-1985.00
ADediting_710729ENST00000311437.11chr19_12576731_-5477-1921.40-1921.80-1985.00
ADediting_710730ENST00000311437.11chr19_12576734_-5474-1924.40-1921.80-1985.00
ADediting_710731ENST00000311437.11chr19_12576735_-5473-1921.50-1921.80-1985.00
ADediting_710732ENST00000311437.11chr19_12576748_-5460-1921.10-1921.80-1985.00
ADediting_710733ENST00000311437.11chr19_12576754_-5454-1921.80-1921.80-1985.00
ADediting_710734ENST00000311437.11chr19_12576755_-5453-1921.10-1921.80-1985.00
ADediting_710735ENST00000311437.11chr19_12576760_-5448-1921.40-1921.80-1985.00
ADediting_710736ENST00000311437.11chr19_12576770_-5438-1921.80-1921.80-1985.00
ADediting_710737ENST00000311437.11chr19_12576771_-5437-1921.10-1921.80-1985.00
ADediting_710738ENST00000311437.11chr19_12576773_-5435-1921.80-1921.80-1985.00
ADediting_710739ENST00000311437.11chr19_12579064_-3144-1925.30-1921.80-1985.00
ADediting_710740ENST00000311437.11chr19_12579201_-3007-1923.00-1921.80-1985.00
ADediting_710741ENST00000311437.11chr19_12579429_-2779-1924.00-1921.80-1985.00
ADediting_1552355ENST00000311437.11chr19_12579439_-2769-1927.10-1921.80-1985.00
ADediting_710742ENST00000311437.11chr19_12579608_-2600-1923.00-1921.80-1985.00
ADediting_710743ENST00000311437.11chr19_12579686_-2522-1922.80-1921.80-1985.00
ADediting_710744ENST00000311437.11chr19_12579689_-2519-1921.80-1921.80-1985.00
ADediting_710745ENST00000311437.11chr19_12579703_-2505-1921.80-1921.80-1985.00

check button RNA A-to-I editing in lncRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for ZNF490

check button Correlation between ADAR gene expression and RNA editing frequency
TissueADeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
CERADediting_710709chr19_12576251_-0.024969481277070.1830302696726942.67005054803077e-060.3725461588737160.01133090634152270.206260615405602
CERADediting_710715chr19_12576366_-0.01445763202941280.1993486455946941.0281033966988e-060.3865683269700440.0299165316038940.177353045134798
CERADediting_710716chr19_12576384_-0.02204271799005080.1868609899707394.24903357874594e-060.3654759266117640.1145038685224490.129405198486896
CERADediting_710722chr19_12576479_-0.02271686417620730.1859414923913251.67838270696923e-050.3435285121606510.08965310043895050.139067437612184
CERADediting_710723chr19_12576558_-0.01085345707669860.2074603422890060.0001035796571263740.31164435014510.1003048724144920.134695792057622

check button Correlation between ADAR gene expression and this gene's expression
TissueADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFC1.42168698949362e-120.3879323926240440.0003586803809286970.2014241018325751.49740254829626e-460.697825478878396
PCC1.83014331268696e-140.5172940068917371.79751841195019e-120.4813794415285390.0005208695583891750.2487401481033
CER1.42392750689099e-330.7923341491446253.24605830579273e-220.6863031422291020.003693887033720470.235667362605467
TCX1.39911403895006e-250.7233783581551396.03629904670791e-100.4782485661236332.94076885766612e-070.404026846362035
FP1.27775811702348e-330.7515237163494413.47936320592509e-240.6660832719245998.55936311282131e-060.326695617749024
IFG1.17660373336467e-060.8056765590333827.58058327145759e-070.8136451962080720.03420179788737490.424979849992867
PG5.03210200424995e-540.8536886095894762.94456008028976e-360.7598892269314290.4982690537447660.049961654159799
STG3.60797076058285e-150.7293678293007748.80895839161125e-120.6597122439986990.02625343298123230.242490313340503

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Relation with AD stages for ZNF490

check button Correlation between AD stages and RNA editing frequency
TissueADeditomIDpositionP-valCoeff.
CERADediting_710709chr19_12576251_-0.001454791228536730.302641853248568
CERADediting_710713chr19_12576343_-0.0002009082150566280.350417186409343

check button Correlation between AD stages and this gene's expression
TissueP-valCoeff.
CER0.0001921044532090260.351414302074115
TCX1.33953783215189e-070.485372661988172

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RelatedDrugs for ZNF490

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF490

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource