ADeditome Logo

Home

Download

Statistics

Landscape

Help

Contact

Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited versus non-edited samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with AD stages

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene


Gene summary for MYORG

check button Gene summary
Gene informationGene symbol

MYORG

Gene ID

57462

Gene namemyogenesis regulating glycosidase (putative)
SynonymsIBGC7|KIAA1161|NET37
Cytomap

9p13.3

Type of geneprotein-coding
Descriptionmyogenesis-regulating glycosidase
Modification date20200315
UniProtAcc

Q6NSJ0,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

Top

RNA A-to-I events for MYORG

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_1464634(34369438, -), ADediting_1464635(34369478, -), ADediting_1464636(34369484, -), ADediting_1464637(34369514, -), ADediting_1464638(34369517, -), ADediting_1464639(34369566, -), ADediting_1464640(34369584, -), ADediting_1464641(34373488, -), ADediting_1464642(34373515, -), ADediting_1464643(34373544, -), ADediting_1464644(34373549, -), ADediting_1464645(34373550, -), ADediting_1464646(34373564, -), ADediting_1464647(34373581, -), ADediting_1464648(34373585, -), ADediting_1464649(34373590, -), ADediting_1464650(34373591, -), ADediting_1464651(34373617, -), ADediting_1464652(34373623, -), ADediting_1464653(34373626, -), ADediting_1464654(34373629, -), ADediting_1464655(34373646, -), ADediting_1464656(34373647, -), ADediting_1464657(34373648, -), ADediting_1464658(34373654, -), ADediting_1464659(34373656, -), ADediting_1464660(34373657, -), ADediting_1464661(34373666, -), ADediting_1464662(34373670, -), ADediting_1464663(34373690, -), ADediting_1464664(34373699, -), ADediting_1464665(34374641, -), ADediting_1464666(34374689, -), ADediting_1464667(34374780, -), ADediting_1464668(34374790, -), ADediting_1464669(34374807, -), ADediting_1464670(34374855, -), ADediting_1464671(34374856, -), ADediting_1464672(34374896, -), ADediting_1593540(34373545, -), ADediting_1672872(34373568, -),

Top

RNA editing positional annotations for MYORG using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_1464634chr9_34369438_-UTR3
ADediting_1464635chr9_34369478_-UTR3
ADediting_1464636chr9_34369484_-UTR3
ADediting_1464637chr9_34369514_-UTR3
ADediting_1464638chr9_34369517_-UTR3
ADediting_1464639chr9_34369566_-UTR3
ADediting_1464640chr9_34369584_-UTR3
ADediting_1464641chr9_34373488_-intronic
ADediting_1464642chr9_34373515_-intronic
ADediting_1464643chr9_34373544_-intronic
ADediting_1464644chr9_34373549_-intronic
ADediting_1464645chr9_34373550_-intronic
ADediting_1464646chr9_34373564_-intronic
ADediting_1464647chr9_34373581_-intronic
ADediting_1464648chr9_34373585_-intronic
ADediting_1464649chr9_34373590_-intronic
ADediting_1464650chr9_34373591_-intronic
ADediting_1464651chr9_34373617_-intronic
ADediting_1464652chr9_34373623_-intronic
ADediting_1464653chr9_34373626_-intronic
ADediting_1464654chr9_34373629_-intronic
ADediting_1464655chr9_34373646_-intronic
ADediting_1464656chr9_34373647_-intronic
ADediting_1464657chr9_34373648_-intronic
ADediting_1464658chr9_34373654_-intronic
ADediting_1464659chr9_34373656_-intronic
ADediting_1464660chr9_34373657_-intronic
ADediting_1464661chr9_34373666_-intronic
ADediting_1464662chr9_34373670_-intronic
ADediting_1464663chr9_34373690_-intronic
ADediting_1464664chr9_34373699_-intronic
ADediting_1464665chr9_34374641_-intronic
ADediting_1464666chr9_34374689_-intronic
ADediting_1464667chr9_34374780_-intronic
ADediting_1464668chr9_34374790_-intronic
ADediting_1464669chr9_34374807_-intronic
ADediting_1464670chr9_34374855_-intronic
ADediting_1464671chr9_34374856_-intronic
ADediting_1464672chr9_34374896_-intronic
ADediting_1593540chr9_34373545_-intronic
ADediting_1672872chr9_34373568_-intronic

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_1464634chr9_34369438_-SINEAluName=AluSg
ADediting_1464635chr9_34369478_-SINEAluName=AluSg
ADediting_1464636chr9_34369484_-SINEAluName=AluSg
ADediting_1464637chr9_34369514_-SINEAluName=AluSg
ADediting_1464638chr9_34369517_-SINEAluName=AluSg
ADediting_1464639chr9_34369566_-SINEAluName=AluSg
ADediting_1464640chr9_34369584_-SINEAluName=AluSg
ADediting_1464641chr9_34373488_-SINEAluName=AluSz
ADediting_1464642chr9_34373515_-SINEAluName=AluSz
ADediting_1464643chr9_34373544_-SINEAluName=AluSz
ADediting_1464644chr9_34373549_-SINEAluName=AluSz
ADediting_1464645chr9_34373550_-SINEAluName=AluSz
ADediting_1464646chr9_34373564_-SINEAluName=AluSz
ADediting_1464647chr9_34373581_-SINEAluName=AluSz
ADediting_1464648chr9_34373585_-SINEAluName=AluSz
ADediting_1464649chr9_34373590_-SINEAluName=AluSz
ADediting_1464650chr9_34373591_-SINEAluName=AluSz
ADediting_1464651chr9_34373617_-SINEAluName=AluSz
ADediting_1464652chr9_34373623_-SINEAluName=AluSz
ADediting_1464653chr9_34373626_-SINEAluName=AluSz
ADediting_1464654chr9_34373629_-SINEAluName=AluSz
ADediting_1464655chr9_34373646_-SINEAluName=AluSz
ADediting_1464656chr9_34373647_-SINEAluName=AluSz
ADediting_1464657chr9_34373648_-SINEAluName=AluSz
ADediting_1464658chr9_34373654_-SINEAluName=AluSz
ADediting_1464659chr9_34373656_-SINEAluName=AluSz
ADediting_1464660chr9_34373657_-SINEAluName=AluSz
ADediting_1464661chr9_34373666_-SINEAluName=AluSz
ADediting_1464662chr9_34373670_-SINEAluName=AluSz
ADediting_1464663chr9_34373690_-SINEAluName=AluSz
ADediting_1464664chr9_34373699_-SINEAluName=AluSz
ADediting_1464665chr9_34374641_-SINEAluName=AluJb
ADediting_1464666chr9_34374689_-SINEAluName=AluJb
ADediting_1464667chr9_34374780_-SINEAluName=AluJb
ADediting_1464668chr9_34374790_-SINEAluName=AluJb
ADediting_1464669chr9_34374807_-SINEAluName=AluJb
ADediting_1464670chr9_34374855_-SINEAluName=AluJb
ADediting_1464671chr9_34374856_-SINEAluName=AluJb
ADediting_1464672chr9_34374896_-SINEAluName=AluJb
ADediting_1593540chr9_34373545_-SINEAluName=AluSz
ADediting_1672872chr9_34373568_-SINEAluName=AluSz

Top

RNA A-to-I editing events in the alternative splicing sites for MYORG

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

Top

Differntial gene expression between RNA A-to-I edited versus non-edited samples for MYORG

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
Soverview
Soverview

check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

Soverview
Soverview
Soverview
ADeditome IDChrPositoingSkipped exonENSGENSTs

Top

Protein coding region RNA A-to-I editings for MYORG

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


Top

The effects of the RNA editing to the miRNA binding sites for MYORG

check buttonRNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
all structure

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1464634chr9_34369438_-ENSG00000164976.9ENST00000297625.8MYORG-201hsa-miR-3189-3pchr934369437343694437mer-m83436943634369459149-20.67
ADediting_1464634chr9_34369438_-ENSG00000164976.9ENST00000297625.8MYORG-201hsa-miR-6813-3pchr934369436343694427mer-m83436943534369455140-16.1
ADediting_1464636chr9_34369484_-ENSG00000164976.9ENST00000297625.8MYORG-201hsa-miR-4786-5pchr934369478343694858mer-1a3436947834369498153-27.29
ADediting_1464636chr9_34369484_-ENSG00000164976.9ENST00000297625.8MYORG-201hsa-miR-6849-3pchr934369483343694897mer-m83436948234369502156-22.23
ADediting_1464638chr9_34369517_-ENSG00000164976.9ENST00000297625.8MYORG-201hsa-miR-3613-3pchr934369517343695237mer-m83436951634369542157-11.07
ADediting_1464639chr9_34369566_-ENSG00000164976.9ENST00000297625.8MYORG-201hsa-miR-3157-5pchr934369561343695677mer-m83436956034369581149-18.58
ADediting_1464639chr9_34369566_-ENSG00000164976.9ENST00000297625.8MYORG-201hsa-miR-4691-3pchr934369561343695688mer-1a3436956134369583141-14.69
ADediting_1464640chr9_34369584_-ENSG00000164976.9ENST00000297625.8MYORG-201hsa-miR-665chr934369583343695897mer-m83436958234369601146-21.37
ADediting_1464640chr9_34369584_-ENSG00000164976.9ENST00000297625.8MYORG-201hsa-miR-6840-3pchr934369582343695887mer-m83436958134369602140-23.26

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1464635chr9_34369478_-ENSG00000164976.9ENST00000297625.8MYORG-201hsa-miR-3672chr934369477343694848mer-1a3436947734369501155-14.15
ADediting_1464635chr9_34369478_-ENSG00000164976.9ENST00000297625.8MYORG-201hsa-miR-6864-3pchr934369477343694848mer-1a3436947734369497145-15.64
ADediting_1464637chr9_34369514_-ENSG00000164976.9ENST00000297625.8MYORG-201hsa-miR-3675-3pchr934369509343695157mer-m83436950834369531148-12.58
ADediting_1464637chr9_34369514_-ENSG00000164976.9ENST00000297625.8MYORG-201hsa-miR-4684-5pchr934369510343695167mer-m83436950934369532155-14.81
ADediting_1464639chr9_34369566_-ENSG00000164976.9ENST00000297625.8MYORG-201hsa-miR-5690chr934369561343695688mer-1a3436956134369581150-17.09
ADediting_1464640chr9_34369584_-ENSG00000164976.9ENST00000297625.8MYORG-201hsa-miR-4266chr934369584343695907mer-m83436958334369598140-17.76

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1337757chr7_5495852_-ENSG00000164976.9ENST00000297625.8MYORG-201hsa-miR-589-3pchr934369638343696447mer-m83436963734369661153-17.88
ADediting_1391023chr8_140732605_-ENSG00000164976.9ENST00000297625.8MYORG-201hsa-miR-151a-3pchr934370267343702737mer-m83437026634370286141-18.61
ADediting_1535951chr14_100874558_+ENSG00000164976.9ENST00000297625.8MYORG-201hsa-miR-337-3pchr934367936343679427mer-m83436793534367956150-19.27
ADediting_1535953chr14_101045971_+ENSG00000164976.9ENST00000297625.8MYORG-201hsa-miR-381-3pchr934367574343675807mer-m83436757334367594142-14.07

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1337757chr7_5495852_-ENSG00000164976.9ENST00000297625.8MYORG-201hsa-miR-589-3pchr934367178343671847mer-m83436717734367201143-12.88
ADediting_1337757chr7_5495852_-ENSG00000164976.9ENST00000297625.8MYORG-201hsa-miR-589-3pchr934369086343690927mer-m83436908534369109155-18.71
ADediting_1556067chr19_40282625_-ENSG00000164976.9ENST00000297625.8MYORG-201hsa-miR-641chr934366976343669827mer-m83436697534366998150-15.28
ADediting_1556067chr19_40282625_-ENSG00000164976.9ENST00000297625.8MYORG-201hsa-miR-641chr934368889343688957mer-m83436888834368911154-13.84
ADediting_1631458chr19_40282624_-ENSG00000164976.9ENST00000297625.8MYORG-201hsa-miR-641chr934366976343669827mer-m83436697534366998150-15.28
ADediting_1631458chr19_40282624_-ENSG00000164976.9ENST00000297625.8MYORG-201hsa-miR-641chr934368889343688957mer-m83436888834368911154-13.84
ADediting_496066chr15_66496985_-ENSG00000164976.9ENST00000297625.8MYORG-201hsa-miR-4512chr934370314343703207mer-m83437031334370335150-21.86
ADediting_527135chr16_24203190_+ENSG00000164976.9ENST00000297625.8MYORG-201hsa-miR-1273h-3pchr934368275343682817mer-m83436827434368296143-23.23

check button Differentially expressed gene-miRNA network

Top

The effects of the RNA editing to the stability of the RNA structures for MYORG

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.
ENST00000297625.8protein_codingSoverviewSoverview

check button RNA A-to-I editing in miRNA.
ADeditom_IDENSTmir_IDEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in mRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI
ADediting_1464634ENST00000297625.8chr9_34369438_-3675-2415.50-2411.07-2432.77
ADediting_1464635ENST00000297625.8chr9_34369478_-3635-2410.77-2411.07-2432.77
ADediting_1464636ENST00000297625.8chr9_34369484_-3629-2414.40-2411.07-2432.77
ADediting_1464637ENST00000297625.8chr9_34369514_-3599-2410.77-2411.07-2432.77
ADediting_1464638ENST00000297625.8chr9_34369517_-3596-2410.37-2411.07-2432.77
ADediting_1464639ENST00000297625.8chr9_34369566_-3547-2415.80-2411.07-2432.77
ADediting_1464640ENST00000297625.8chr9_34369584_-3529-2417.27-2411.07-2432.77

check button RNA A-to-I editing in lncRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

Top

Relation with ADAR for MYORG

check button Correlation between ADAR gene expression and RNA editing frequency
TissueADeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
CERADediting_1464638chr9_34369517_-0.5423612434364490.05013283587102270.0001822889321835580.3009656399760910.09027285748622740.138802077472055
DLPFCADediting_1464659chr9_34373656_-0.1717483107685620.07781471604025920.614796953551185-0.0286920210817593.59092251903804e-130.397393496672218
CERADediting_1464659chr9_34373656_-0.01806097418646560.1928471434195980.0001307947542713010.3072864183558390.0003845285684733670.286201480861383
CERADediting_1464662chr9_34373670_-0.02412848157792330.1840897277620150.00039519038176840.2856450543132550.0001734771019241240.301918216559779

check button Correlation between ADAR gene expression and this gene's expression
TissueADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFC1.42376392994685e-070.2934503560505560.0009547145485017660.1867299960599062.08646053958112e-090.331908734937816
AC1.16900093786029e-270.6173709355512732.03602456179439e-160.4887709658691822.26662996010506e-240.585207721942563
PCC2.32501215407316e-050.30100064836720.001539284894441820.2276464260213259.98781299128227e-090.399869795679014
CER7.93265833280682e-060.3557033351051820.03842987383142030.169228898563574.88099957861855e-140.565218338479385
FP0.610121456536491-0.03847554191156640.000759476541367334-0.2501176034692234.27569540057482e-090.422408635543844
IFG2.83979833593307e-050.7351381575128333.70968112082172e-060.7830190768159360.005263431753675040.540668254530004
STG0.357649343039561-0.1016268342342710.014742792221247-0.2652663775033729.79375573552782e-060.461801723968612

Top

Relation with AD stages for MYORG

check button Correlation between AD stages and RNA editing frequency
TissueADeditomIDpositionP-valCoeff.
IFGADediting_1464638chr9_34369517_-0.04897706951583-0.397704204776515
IFGADediting_1464640chr9_34369584_-0.04897706951583-0.397704204776515

check button Correlation between AD stages and this gene's expression
TissueP-valCoeff.
CER3.91195595730968e-050.384860587825215
TCX7.96108087836767e-070.457985890711239

Top

RelatedDrugs for MYORG

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for MYORG

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource