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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited versus non-edited samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with AD stages

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene


Gene summary for ATP8B2

check button Gene summary
Gene informationGene symbol

ATP8B2

Gene ID

57198

Gene nameATPase phospholipid transporting 8B2
SynonymsATPID
Cytomap

1q21.3

Type of geneprotein-coding
Descriptionphospholipid-transporting ATPase ID36/8-9 fusion protein with epitope for anti-lectin antibodyATPase, aminophospholipid transporter, class I, type 8B, member 2ATPase, class I, type 8B, member 2P4-ATPase flippase complex alpha subunit ATP8B2probable p
Modification date20200313
UniProtAcc

P98198,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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RNA A-to-I events for ATP8B2

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_27895(154333055, +), ADediting_27896(154333071, +), ADediting_27897(154333124, +), ADediting_27898(154333132, +), ADediting_27899(154333133, +), ADediting_27900(154333134, +), ADediting_27901(154333192, +), ADediting_27902(154333193, +), ADediting_27903(154333206, +), ADediting_27904(154333210, +), ADediting_27905(154333219, +), ADediting_27906(154333313, +), ADediting_27907(154333348, +), ADediting_27908(154333383, +), ADediting_27909(154333389, +), ADediting_27910(154333398, +), ADediting_27911(154333445, +), ADediting_27912(154333728, +), ADediting_27913(154333735, +), ADediting_27914(154333768, +), ADediting_27915(154333774, +), ADediting_27916(154333887, +), ADediting_27917(154333897, +), ADediting_27918(154333915, +), ADediting_27919(154335437, +), ADediting_27920(154335459, +), ADediting_27921(154335482, +), ADediting_27922(154335492, +), ADediting_27923(154335493, +), ADediting_27924(154335494, +), ADediting_27925(154335510, +), ADediting_27926(154335545, +), ADediting_27927(154335549, +), ADediting_27928(154335561, +), ADediting_27929(154335577, +), ADediting_27930(154335581, +), ADediting_27931(154335588, +), ADediting_27932(154335625, +), ADediting_27933(154335670, +), ADediting_27934(154335671, +), ADediting_27935(154335674, +), ADediting_27936(154335675, +), ADediting_27937(154335678, +), ADediting_27938(154335679, +), ADediting_27939(154335784, +), ADediting_27940(154335785, +), ADediting_27941(154335829, +), ADediting_27942(154335836, +), ADediting_27943(154335837, +), ADediting_27944(154335852, +), ADediting_27945(154335892, +), ADediting_27946(154335918, +), ADediting_27947(154335928, +), ADediting_27948(154335941, +), ADediting_27949(154335945, +), ADediting_27950(154335948, +), ADediting_27951(154335949, +), ADediting_27952(154335950, +), ADediting_27953(154335951, +), ADediting_27954(154335960, +), ADediting_27955(154336029, +), ADediting_27956(154336030, +), ADediting_27957(154336515, +), ADediting_27958(154336568, +), ADediting_27959(154336605, +), ADediting_27960(154336614, +), ADediting_27961(154336617, +), ADediting_27962(154336629, +), ADediting_27963(154336645, +), ADediting_27964(154336697, +), ADediting_27965(154336719, +), ADediting_27966(154336731, +), ADediting_27967(154336734, +), ADediting_27968(154336756, +), ADediting_27969(154336757, +), ADediting_27970(154336769, +), ADediting_27971(154336850, +), ADediting_27972(154336895, +), ADediting_27973(154336899, +), ADediting_27974(154336921, +), ADediting_27975(154336924, +), ADediting_27976(154336929, +), ADediting_27977(154336934, +), ADediting_27978(154336936, +), ADediting_27979(154336978, +), ADediting_27980(154336981, +), ADediting_27981(154337018, +), ADediting_27982(154337050, +), ADediting_27983(154337060, +), ADediting_27984(154340171, +), ADediting_27985(154346916, +), ADediting_27986(154347000, +), ADediting_27987(154347019, +), ADediting_27988(154347029, +), ADediting_27989(154347124, +), ADediting_27990(154347129, +), ADediting_27991(154347152, +), ADediting_27992(154347164, +), ADediting_27993(154347166, +), ADediting_27994(154347678, +), ADediting_27995(154347683, +), ADediting_27996(154347740, +), ADediting_27997(154347776, +), ADediting_27998(154347779, +), ADediting_27999(154347780, +), ADediting_28000(154350160, +), ADediting_1515107(154333054, +), ADediting_1515108(154333154, +), ADediting_1515109(154333357, +), ADediting_1515110(154333709, +), ADediting_1515111(154335414, +), ADediting_1515112(154335442, +), ADediting_1515113(154335445, +), ADediting_1515114(154335453, +), ADediting_1515115(154335458, +), ADediting_1515116(154335485, +), ADediting_1515117(154335496, +), ADediting_1515118(154335514, +), ADediting_1515119(154335533, +), ADediting_1515120(154335661, +), ADediting_1515121(154335673, +), ADediting_1515122(154335762, +), ADediting_1515123(154335924, +), ADediting_1515124(154335980, +), ADediting_1515125(154336012, +), ADediting_1515126(154336523, +), ADediting_1515127(154336643, +), ADediting_1515128(154336846, +), ADediting_1515129(154336856, +), ADediting_1515130(154337032, +), ADediting_1515131(154337059, +), ADediting_1515132(154337061, +),

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RNA editing positional annotations for ATP8B2 using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_27895chr1_154333055_+intronic
ADediting_27896chr1_154333071_+intronic
ADediting_27897chr1_154333124_+intronic
ADediting_27898chr1_154333132_+intronic
ADediting_27899chr1_154333133_+intronic
ADediting_27900chr1_154333134_+intronic
ADediting_27901chr1_154333192_+intronic
ADediting_27902chr1_154333193_+intronic
ADediting_27903chr1_154333206_+intronic
ADediting_27904chr1_154333210_+intronic
ADediting_27905chr1_154333219_+intronic
ADediting_27906chr1_154333313_+intronic
ADediting_27907chr1_154333348_+intronic
ADediting_27908chr1_154333383_+intronic
ADediting_27909chr1_154333389_+intronic
ADediting_27910chr1_154333398_+intronic
ADediting_27911chr1_154333445_+intronic
ADediting_27912chr1_154333728_+intronic
ADediting_27913chr1_154333735_+intronic
ADediting_27914chr1_154333768_+intronic
ADediting_27915chr1_154333774_+intronic
ADediting_27916chr1_154333887_+intronic
ADediting_27917chr1_154333897_+intronic
ADediting_27918chr1_154333915_+intronic
ADediting_27919chr1_154335437_+intronic
ADediting_27920chr1_154335459_+intronic
ADediting_27921chr1_154335482_+intronic
ADediting_27922chr1_154335492_+intronic
ADediting_27923chr1_154335493_+intronic
ADediting_27924chr1_154335494_+intronic
ADediting_27925chr1_154335510_+intronic
ADediting_27926chr1_154335545_+intronic
ADediting_27927chr1_154335549_+intronic
ADediting_27928chr1_154335561_+intronic
ADediting_27929chr1_154335577_+intronic
ADediting_27930chr1_154335581_+intronic
ADediting_27931chr1_154335588_+intronic
ADediting_27932chr1_154335625_+intronic
ADediting_27933chr1_154335670_+intronic
ADediting_27934chr1_154335671_+intronic
ADediting_27935chr1_154335674_+intronic
ADediting_27936chr1_154335675_+intronic
ADediting_27937chr1_154335678_+intronic
ADediting_27938chr1_154335679_+intronic
ADediting_27939chr1_154335784_+intronic
ADediting_27940chr1_154335785_+intronic
ADediting_27941chr1_154335829_+intronic
ADediting_27942chr1_154335836_+intronic
ADediting_27943chr1_154335837_+intronic
ADediting_27944chr1_154335852_+intronic
ADediting_27945chr1_154335892_+intronic
ADediting_27946chr1_154335918_+intronic
ADediting_27947chr1_154335928_+intronic
ADediting_27948chr1_154335941_+intronic
ADediting_27949chr1_154335945_+intronic
ADediting_27950chr1_154335948_+intronic
ADediting_27951chr1_154335949_+intronic
ADediting_27952chr1_154335950_+intronic
ADediting_27953chr1_154335951_+intronic
ADediting_27954chr1_154335960_+intronic
ADediting_27955chr1_154336029_+intronic
ADediting_27956chr1_154336030_+intronic
ADediting_27957chr1_154336515_+intronic
ADediting_27958chr1_154336568_+intronic
ADediting_27959chr1_154336605_+intronic
ADediting_27960chr1_154336614_+intronic
ADediting_27961chr1_154336617_+intronic
ADediting_27962chr1_154336629_+intronic
ADediting_27963chr1_154336645_+intronic
ADediting_27964chr1_154336697_+intronic
ADediting_27965chr1_154336719_+intronic
ADediting_27966chr1_154336731_+intronic
ADediting_27967chr1_154336734_+intronic
ADediting_27968chr1_154336756_+intronic
ADediting_27969chr1_154336757_+intronic
ADediting_27970chr1_154336769_+intronic
ADediting_27971chr1_154336850_+intronic
ADediting_27972chr1_154336895_+intronic
ADediting_27973chr1_154336899_+intronic
ADediting_27974chr1_154336921_+intronic
ADediting_27975chr1_154336924_+intronic
ADediting_27976chr1_154336929_+intronic
ADediting_27977chr1_154336934_+intronic
ADediting_27978chr1_154336936_+intronic
ADediting_27979chr1_154336978_+intronic
ADediting_27980chr1_154336981_+intronic
ADediting_27981chr1_154337018_+intronic
ADediting_27982chr1_154337050_+intronic
ADediting_27983chr1_154337060_+intronic
ADediting_27984chr1_154340171_+intronic
ADediting_27985chr1_154346916_+intronic
ADediting_27986chr1_154347000_+intronic
ADediting_27987chr1_154347019_+intronic
ADediting_27988chr1_154347029_+intronic
ADediting_27989chr1_154347124_+intronic
ADediting_27990chr1_154347129_+intronic
ADediting_27991chr1_154347152_+intronic
ADediting_27992chr1_154347164_+intronic
ADediting_27993chr1_154347166_+intronic
ADediting_27994chr1_154347678_+intronic
ADediting_27995chr1_154347683_+intronic
ADediting_27996chr1_154347740_+intronic
ADediting_27997chr1_154347776_+intronic
ADediting_27998chr1_154347779_+intronic
ADediting_27999chr1_154347780_+intronic
ADediting_28000chr1_154350160_+UTR3
ADediting_1515107chr1_154333054_+intronic
ADediting_1515108chr1_154333154_+intronic
ADediting_1515109chr1_154333357_+intronic
ADediting_1515110chr1_154333709_+intronic
ADediting_1515111chr1_154335414_+intronic
ADediting_1515112chr1_154335442_+intronic
ADediting_1515113chr1_154335445_+intronic
ADediting_1515114chr1_154335453_+intronic
ADediting_1515115chr1_154335458_+intronic
ADediting_1515116chr1_154335485_+intronic
ADediting_1515117chr1_154335496_+intronic
ADediting_1515118chr1_154335514_+intronic
ADediting_1515119chr1_154335533_+intronic
ADediting_1515120chr1_154335661_+intronic
ADediting_1515121chr1_154335673_+intronic
ADediting_1515122chr1_154335762_+intronic
ADediting_1515123chr1_154335924_+intronic
ADediting_1515124chr1_154335980_+intronic
ADediting_1515125chr1_154336012_+intronic
ADediting_1515126chr1_154336523_+intronic
ADediting_1515127chr1_154336643_+intronic
ADediting_1515128chr1_154336846_+intronic
ADediting_1515129chr1_154336856_+intronic
ADediting_1515130chr1_154337032_+intronic
ADediting_1515131chr1_154337059_+intronic
ADediting_1515132chr1_154337061_+intronic

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_27895chr1_154333055_+SINEAluName=AluSq2
ADediting_27896chr1_154333071_+SINEAluName=AluSq2
ADediting_27897chr1_154333124_+SINEAluName=AluSq2
ADediting_27898chr1_154333132_+SINEAluName=AluSq2
ADediting_27899chr1_154333133_+SINEAluName=AluSq2
ADediting_27900chr1_154333134_+SINEAluName=AluSq2
ADediting_27901chr1_154333192_+SINEAluName=AluSq2
ADediting_27902chr1_154333193_+SINEAluName=AluSq2
ADediting_27903chr1_154333206_+SINEAluName=AluSq2
ADediting_27904chr1_154333210_+SINEAluName=AluSq2
ADediting_27905chr1_154333219_+SINEAluName=AluSq2
ADediting_27906chr1_154333313_+SINEAluName=AluSq2
ADediting_27907chr1_154333348_+SINEAluName=AluSq2
ADediting_27908chr1_154333383_+SINEAluName=AluSz6
ADediting_27909chr1_154333389_+SINEAluName=AluSz6
ADediting_27910chr1_154333398_+SINEAluName=AluSz6
ADediting_27911chr1_154333445_+SINEAluName=AluSz6
ADediting_27912chr1_154333728_+SINEAluName=AluSq
ADediting_27913chr1_154333735_+SINEAluName=AluSq
ADediting_27914chr1_154333768_+SINEAluName=AluSq
ADediting_27915chr1_154333774_+SINEAluName=AluSq
ADediting_27916chr1_154333887_+SINEAluName=AluSq
ADediting_27917chr1_154333897_+SINEAluName=AluSq
ADediting_27918chr1_154333915_+SINEAluName=AluSq
ADediting_27919chr1_154335437_+SINEAluName=AluJo
ADediting_27920chr1_154335459_+SINEAluName=AluJo
ADediting_27921chr1_154335482_+SINEAluName=AluJo
ADediting_27922chr1_154335492_+SINEAluName=AluJo
ADediting_27923chr1_154335493_+SINEAluName=AluJo
ADediting_27924chr1_154335494_+SINEAluName=AluJo
ADediting_27925chr1_154335510_+SINEAluName=AluJo
ADediting_27926chr1_154335545_+SINEAluName=AluJo
ADediting_27927chr1_154335549_+SINEAluName=AluJo
ADediting_27928chr1_154335561_+SINEAluName=AluJo
ADediting_27929chr1_154335577_+SINEAluName=AluJo
ADediting_27930chr1_154335581_+SINEAluName=AluJo
ADediting_27931chr1_154335588_+SINEAluName=AluJo
ADediting_27932chr1_154335625_+SINEAluName=AluJo
ADediting_27933chr1_154335670_+SINEAluName=AluJo
ADediting_27934chr1_154335671_+SINEAluName=AluJo
ADediting_27935chr1_154335674_+SINEAluName=AluJo
ADediting_27936chr1_154335675_+SINEAluName=AluJo
ADediting_27937chr1_154335678_+SINEAluName=AluJo
ADediting_27938chr1_154335679_+SINEAluName=AluJo
ADediting_27939chr1_154335784_+SINEAluName=AluY
ADediting_27940chr1_154335785_+SINEAluName=AluY
ADediting_27941chr1_154335829_+SINEAluName=AluY
ADediting_27942chr1_154335836_+SINEAluName=AluY
ADediting_27943chr1_154335837_+SINEAluName=AluY
ADediting_27944chr1_154335852_+SINEAluName=AluY
ADediting_27945chr1_154335892_+SINEAluName=AluY
ADediting_27946chr1_154335918_+SINEAluName=AluY
ADediting_27947chr1_154335928_+SINEAluName=AluY
ADediting_27948chr1_154335941_+SINEAluName=AluY
ADediting_27949chr1_154335945_+SINEAluName=AluY
ADediting_27950chr1_154335948_+SINEAluName=AluY
ADediting_27951chr1_154335949_+SINEAluName=AluY
ADediting_27952chr1_154335950_+SINEAluName=AluY
ADediting_27953chr1_154335951_+SINEAluName=AluY
ADediting_27954chr1_154335960_+SINEAluName=AluY
ADediting_27955chr1_154336029_+SINEAluName=AluY
ADediting_27956chr1_154336030_+SINEAluName=AluY
ADediting_27957chr1_154336515_+SINEAluName=AluSx1
ADediting_27958chr1_154336568_+SINEAluName=AluSx1
ADediting_27959chr1_154336605_+SINEAluName=AluSx1
ADediting_27960chr1_154336614_+SINEAluName=AluSx1
ADediting_27961chr1_154336617_+SINEAluName=AluSx1
ADediting_27962chr1_154336629_+SINEAluName=AluSx1
ADediting_27963chr1_154336645_+SINEAluName=AluSx1
ADediting_27964chr1_154336697_+SINEAluName=AluSx1
ADediting_27965chr1_154336719_+SINEAluName=AluSx1
ADediting_27966chr1_154336731_+SINEAluName=AluSx1
ADediting_27967chr1_154336734_+SINEAluName=AluSx1
ADediting_27968chr1_154336756_+SINEAluName=AluSx1
ADediting_27969chr1_154336757_+SINEAluName=AluSx1
ADediting_27970chr1_154336769_+SINEAluName=AluSx1
ADediting_27971chr1_154336850_+SINEAluName=AluSx
ADediting_27972chr1_154336895_+SINEAluName=AluSx
ADediting_27973chr1_154336899_+SINEAluName=AluSx
ADediting_27974chr1_154336921_+SINEAluName=AluSx
ADediting_27975chr1_154336924_+SINEAluName=AluSx
ADediting_27976chr1_154336929_+SINEAluName=AluSx
ADediting_27977chr1_154336934_+SINEAluName=AluSx
ADediting_27978chr1_154336936_+SINEAluName=AluSx
ADediting_27979chr1_154336978_+SINEAluName=AluSx
ADediting_27980chr1_154336981_+SINEAluName=AluSx
ADediting_27981chr1_154337018_+SINEAluName=AluSx
ADediting_27982chr1_154337050_+SINEAluName=AluSx
ADediting_27983chr1_154337060_+SINEAluName=AluSx
ADediting_27984chr1_154340171_+SINEAluName=AluJr
ADediting_27985chr1_154346916_+SINEAluName=AluSx
ADediting_27986chr1_154347000_+SINEAluName=AluSx
ADediting_27987chr1_154347019_+SINEAluName=AluSx
ADediting_27988chr1_154347029_+SINEAluName=AluSx
ADediting_27989chr1_154347124_+SINEAluName=AluSx
ADediting_27990chr1_154347129_+SINEAluName=AluSx
ADediting_27991chr1_154347152_+SINEAluName=AluSx
ADediting_27992chr1_154347164_+SINEAluName=AluSx
ADediting_27993chr1_154347166_+SINEAluName=AluSx
ADediting_27994chr1_154347678_+SINEAluName=AluSp
ADediting_27995chr1_154347683_+SINEAluName=AluSp
ADediting_27996chr1_154347740_+SINEAluName=AluSp
ADediting_27997chr1_154347776_+SINEAluName=AluSp
ADediting_27998chr1_154347779_+SINEAluName=AluSp
ADediting_27999chr1_154347780_+SINEAluName=AluSp
ADediting_28000chr1_154350160_+SINEAluName=AluSg
ADediting_1515107chr1_154333054_+SINEAluName=AluSq2
ADediting_1515108chr1_154333154_+SINEAluName=AluSq2
ADediting_1515109chr1_154333357_+SINEAluName=AluSz6
ADediting_1515110chr1_154333709_+SINEAluName=AluSq
ADediting_1515111chr1_154335414_+SINEAluName=AluJo
ADediting_1515112chr1_154335442_+SINEAluName=AluJo
ADediting_1515113chr1_154335445_+SINEAluName=AluJo
ADediting_1515114chr1_154335453_+SINEAluName=AluJo
ADediting_1515115chr1_154335458_+SINEAluName=AluJo
ADediting_1515116chr1_154335485_+SINEAluName=AluJo
ADediting_1515117chr1_154335496_+SINEAluName=AluJo
ADediting_1515118chr1_154335514_+SINEAluName=AluJo
ADediting_1515119chr1_154335533_+SINEAluName=AluJo
ADediting_1515120chr1_154335661_+SINEAluName=AluJo
ADediting_1515121chr1_154335673_+SINEAluName=AluJo
ADediting_1515122chr1_154335762_+SINEAluName=AluY
ADediting_1515123chr1_154335924_+SINEAluName=AluY
ADediting_1515124chr1_154335980_+SINEAluName=AluY
ADediting_1515125chr1_154336012_+SINEAluName=AluY
ADediting_1515126chr1_154336523_+SINEAluName=AluSx1
ADediting_1515127chr1_154336643_+SINEAluName=AluSx1
ADediting_1515128chr1_154336846_+SINEAluName=AluSx
ADediting_1515129chr1_154336856_+SINEAluName=AluSx
ADediting_1515130chr1_154337032_+SINEAluName=AluSx
ADediting_1515131chr1_154337059_+SINEAluName=AluSx
ADediting_1515132chr1_154337061_+SINEAluName=AluSx

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RNA A-to-I editing events in the alternative splicing sites for ATP8B2

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for ATP8B2

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
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check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
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check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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ADeditome IDChrPositoingSkipped exonENSGENSTs

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Protein coding region RNA A-to-I editings for ATP8B2

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for ATP8B2

check buttonRNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
all structure

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_28000chr1_154350160_+ENSG00000143515.18ENST00000368489.5ATP8B2-202hsa-miR-25-5pchr11543501551543501617mer-m8154350143154350162143-19.97
ADediting_28000chr1_154350160_+ENSG00000143515.18ENST00000368489.5ATP8B2-202hsa-miR-658chr11543501541543501607mer-m8154350133154350161152-28.56
ADediting_28000chr1_154350160_+ENSG00000143515.18ENST00000672630.1ATP8B2-207hsa-miR-25-5pchr11543501551543501617mer-m8154350143154350162143-19.97
ADediting_28000chr1_154350160_+ENSG00000143515.18ENST00000672630.1ATP8B2-207hsa-miR-658chr11543501541543501607mer-m8154350133154350161152-28.56

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_28000chr1_154350160_+ENSG00000143515.18ENST00000368489.5ATP8B2-202hsa-miR-3689dchr11543501581543501647mer-m8154350145154350165146-14.77
ADediting_28000chr1_154350160_+ENSG00000143515.18ENST00000368489.5ATP8B2-202hsa-miR-6851-5pchr11543501581543501647mer-m8154350143154350165146-26.08
ADediting_28000chr1_154350160_+ENSG00000143515.18ENST00000368489.5ATP8B2-202hsa-miR-7847-3pchr11543501541543501607mer-m8154350137154350161148-22.2
ADediting_28000chr1_154350160_+ENSG00000143515.18ENST00000672630.1ATP8B2-207hsa-miR-3689dchr11543501581543501647mer-m8154350145154350165146-14.77
ADediting_28000chr1_154350160_+ENSG00000143515.18ENST00000672630.1ATP8B2-207hsa-miR-6851-5pchr11543501581543501647mer-m8154350143154350165146-26.08
ADediting_28000chr1_154350160_+ENSG00000143515.18ENST00000672630.1ATP8B2-207hsa-miR-7847-3pchr11543501541543501607mer-m8154350137154350161148-22.2

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1097295chr3_85385762_+ENSG00000143515.18ENST00000368489.5ATP8B2-202hsa-miR-5688chr11543510881543510947mer-m8154351073154351095155-11.36
ADediting_1097295chr3_85385762_+ENSG00000143515.18ENST00000672630.1ATP8B2-207hsa-miR-5688chr11543510881543510947mer-m8154351073154351095155-11.36
ADediting_1337757chr7_5495852_-ENSG00000143515.18ENST00000368489.5ATP8B2-202hsa-miR-589-3pchr11543497901543497967mer-m8154349774154349797143-16.59
ADediting_1337757chr7_5495852_-ENSG00000143515.18ENST00000672630.1ATP8B2-207hsa-miR-589-3pchr11543497901543497967mer-m8154349774154349797143-16.59
ADediting_1471004chr9_63819627_+ENSG00000143515.18ENST00000368489.5ATP8B2-202hsa-miR-4477bchr11543507481543507558mer-1a154350731154350755142-14.58
ADediting_1471004chr9_63819627_+ENSG00000143515.18ENST00000672630.1ATP8B2-207hsa-miR-4477bchr11543507481543507558mer-1a154350731154350755142-14.58
ADediting_1535953chr14_101045971_+ENSG00000143515.18ENST00000368489.5ATP8B2-202hsa-miR-381-3pchr11543504621543504687mer-m8154350450154350469151-13.93
ADediting_1535953chr14_101045971_+ENSG00000143515.18ENST00000672630.1ATP8B2-207hsa-miR-381-3pchr11543504621543504687mer-m8154350450154350469151-13.93
ADediting_1556067chr19_40282625_-ENSG00000143515.18ENST00000368489.5ATP8B2-202hsa-miR-641chr11543495831543495897mer-m8154349564154349590148-17.29
ADediting_1556067chr19_40282625_-ENSG00000143515.18ENST00000672630.1ATP8B2-207hsa-miR-641chr11543495831543495897mer-m8154349564154349590148-17.29

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1337758chr7_5495892_-ENSG00000143515.18ENST00000368489.5ATP8B2-202hsa-miR-589-5pchr11543511451543511517mer-m8154351131154351152145-11.63
ADediting_1337758chr7_5495892_-ENSG00000143515.18ENST00000672630.1ATP8B2-207hsa-miR-589-5pchr11543511451543511517mer-m8154351131154351152145-11.63
ADediting_496066chr15_66496985_-ENSG00000143515.18ENST00000368489.5ATP8B2-202hsa-miR-4512chr11543492881543492947mer-m8154349272154349295147-17.93
ADediting_496066chr15_66496985_-ENSG00000143515.18ENST00000368489.5ATP8B2-202hsa-miR-4512chr11543494931543494997mer-1a154349478154349499141-19.13
ADediting_496066chr15_66496985_-ENSG00000143515.18ENST00000672630.1ATP8B2-207hsa-miR-4512chr11543492881543492947mer-m8154349272154349295147-17.93
ADediting_496066chr15_66496985_-ENSG00000143515.18ENST00000672630.1ATP8B2-207hsa-miR-4512chr11543494931543494997mer-1a154349478154349499141-19.13
ADediting_843620chr2_207754818_+ENSG00000143515.18ENST00000368489.5ATP8B2-202hsa-miR-4775chr11543512421543512487mer-m8154351228154351249145-3.49
ADediting_843620chr2_207754818_+ENSG00000143515.18ENST00000672630.1ATP8B2-207hsa-miR-4775chr11543512421543512487mer-m8154351228154351249145-3.49

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for ATP8B2

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.
ENST00000368489.5protein_codingSoverviewSoverview
ENST00000672630.1protein_codingSoverviewSoverview

check button RNA A-to-I editing in miRNA.
ADeditom_IDENSTmir_IDEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in mRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI
ADediting_28000ENST00000368489.5chr1_154350160_+4767-2155.70-2156.10-2155.70
ADediting_28000ENST00000672630.1chr1_154350160_+4714-2143.20-2143.50-2143.20

check button RNA A-to-I editing in lncRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for ATP8B2

check button Correlation between ADAR gene expression and RNA editing frequency
TissueADeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
CERADediting_1515108chr1_154333154_+0.01194273313059390.2047865443176760.0001193800030034610.3090003459421850.2504781086320680.0944109198064315
CERADediting_1515120chr1_154335661_+1.3142371671288e-070.4147561226894458.15486175099596e-090.4491588990722460.2705515681457360.0905335154434369
CERADediting_1515129chr1_154336856_+5.14007295615593e-050.3243432252569141.24632111050239e-060.3837922658313480.5545111022210060.0486343633636858
CERADediting_1515132chr1_154337061_+4.00734489991387e-050.3287219989534671.3378014093497e-050.3472665604405270.8490641554085030.0156690867025186
CERADediting_27897chr1_154333124_+0.04740377618054460.1621681121515785.98187908156569e-060.3601615216901970.302394572068570.0847636991430398
CERADediting_27898chr1_154333132_+0.01300404033997020.2023798888506314.69559364283653e-070.3976159875399150.1724123548257840.111996473739148
DLPFCADediting_27900chr1_154333134_+0.6538239858106940.0255697313901430.323314484366176-0.0562787456622793.76215418877005e-100.346092164024793
CERADediting_27900chr1_154333134_+0.1396880021711080.121161615585698.37352724643917e-050.3155593392422710.05991720316459630.15398650966795
CERADediting_27903chr1_154333206_+0.02927798245422040.1780386302475980.0001465231952505430.3051403744564420.2262909449317450.0993801102943492
CERADediting_27904chr1_154333210_+0.01197159147912080.2047186670010281.28944834234918e-050.3478688212741290.298752412348750.08540249516384
CERADediting_27905chr1_154333219_+0.01089711855398910.2073487226230835.28999865543931e-050.3238331672343690.1934601824794260.106767494609454
CERADediting_27907chr1_154333348_+0.01158214108917220.2056470554424160.0001228806349744260.3084590270303250.2307782099571130.0984310282611649
CERADediting_27908chr1_154333383_+0.01083330908755260.2075119834689815.11386224574463e-070.3964323342072830.04775582245183470.161914693819095
CERADediting_27909chr1_154333389_+0.005312912538530550.226520928312861.04771664876161e-060.3862969010352420.03852557857688270.169146610971818
CERADediting_27910chr1_154333398_+0.02113153458600680.1881430673684940.0001597842498357070.3034917906630550.7420977802878330.0270906864472193
CERADediting_27912chr1_154333728_+0.007864969670966850.2162445754299350.0001398581825531870.3060222008207710.8506974290221570.0154975245465101
CERADediting_27913chr1_154333735_+0.01425941243577470.1997458680406338.35704755679279e-060.3548727567852730.1002039217521960.134735458330751
CERADediting_27914chr1_154333768_+0.009161050726622710.2121251500804251.70549770972605e-050.3432625596827840.1775117557227210.110688295359788
CERADediting_27915chr1_154333774_+0.0101975846969130.20918647433885.06576963847588e-060.3627561075309570.06947371255169960.148639759658155
CERADediting_27916chr1_154333887_+0.03454374566546390.1727257861070732.13332275888301e-050.3395227114227250.02788716677398550.179577133258664
DLPFCADediting_27917chr1_154333897_+0.1317204913596780.08580050117137710.8364000401219670.01177559939792352.03629622663669e-080.311844379456294
CERADediting_27921chr1_154335482_+2.08798979296057e-080.4379459910159445.32251407504671e-110.5031260301903280.002863378446457470.241879633713505
CERADediting_27922chr1_154335492_+4.300923040652e-120.526943041879612.84521778551183e-150.5871882315780380.004516616185993320.230649512479356
TCXADediting_27922chr1_154335492_+5.19530088591766e-050.3241537318191765.00547886119639e-060.3629421175780680.720000833973775-0.0295084231341961
CERADediting_27925chr1_154335510_+4.44680173232266e-150.583843545491231.75611889935084e-140.5733097449487660.002607209810425640.244127343153876
CERADediting_27926chr1_154335545_+1.41828520918095e-080.4426077513808722.08665419973364e-050.3398944367214240.6463896547393860.0377620459838307
CERADediting_27927chr1_154335549_+1.63983712295923e-050.343913640415091.90280373773525e-060.3775984823262890.09650816722683550.136209842331086
CERADediting_27930chr1_154335581_+1.57561819217468e-110.514881245065667.98639450218778e-140.5612408580684410.1144911268307610.129409709783715
CERADediting_27931chr1_154335588_+8.47386911876100e-090.448709090745761.40275039395877e-090.4691214572964630.300910593824220.0850233572003679
CERADediting_27934chr1_154335671_+2.25639922795976e-100.4885710191140538.57652198624117e-100.4744793089799380.4116290545868810.0675251572877752
CERADediting_27935chr1_154335674_+5.21701972898816e-100.479800546711641.64083170297455e-120.5355969271268430.08249104980773580.142245523659506
CERADediting_27936chr1_154335675_+0.001242691293474440.2612302803591710.0001192128561449750.3090265615929910.6611051241670510.0360844226773425
CERADediting_27937chr1_154335678_+1.49648977705926e-060.3811301826249263.08258158654963e-050.3332658258004660.3833832582359520.0716803621730292
CERADediting_27940chr1_154335785_+2.32809446286961e-100.4882481236916157.57671731343871e-090.4500190526881890.1974926435664360.105813718741427
CERADediting_27951chr1_154335949_+0.002633662924634740.2438862023287669.10300735894203e-050.3140282109615960.39736787820330.0696010651272732
CERADediting_27954chr1_154335960_+0.001866447267355340.2519840980887460.0001814984256644230.3010493251310950.4823196487086620.0578006839244165
DLPFCADediting_27955chr1_154336029_+0.328178311110230.05571665871693160.9955401277139540.0003187584924752521.07315009014755e-080.317636068573228
CERADediting_27955chr1_154336029_+4.46043415320428e-080.4285876654567552.15006636417021e-080.4375899852858680.6238909736146980.0403576576608198
CERADediting_27956chr1_154336030_+3.29651151420313e-070.4024747720944684.49757975765331e-070.3982118990435670.897084543424953-0.0106497787222675
CERADediting_27957chr1_154336515_+4.66211434297648e-120.5262076035504872.13317945372911e-100.4891498709643190.2239910968440940.0998716978969105
CERADediting_27959chr1_154336605_+1.34645426904339e-050.3471609579652193.43324273712049e-050.331408576821820.4771281469325930.0584866735032546
CERADediting_27960chr1_154336614_+2.17427574091242e-050.3392027706652688.28555733566171e-050.3157523423029390.3185696932639970.0819861446281314
CERADediting_27961chr1_154336617_+4.24452535064633e-060.3654922736885331.12678346688189e-050.3500644358339570.9458697534499750.00559027078870825
DLPFCADediting_27963chr1_154336645_+0.9940445685794930.0004256516607873560.33231344207229-0.05524299879012077.14361438841016e-080.300120508666608
CERADediting_27963chr1_154336645_+4.43081234581253e-050.3269630708909633.30740416404856e-050.3320536472787550.869707393822394-0.0135053753640352
CERADediting_27964chr1_154336697_+8.62128439783611e-060.3543755464841494.45818472076475e-070.3983334380446840.3659556089362120.0743370839319877
CERADediting_27965chr1_154336719_+7.00901703665559e-070.3920191689723360.0002658894583389530.2935983661191070.299210376705882-0.0853218916200035
CERADediting_27966chr1_154336731_+1.89291543800811e-080.4391348998324519.89394369473023e-090.4468862745575430.3148618861035050.0826145634985028
CERADediting_27968chr1_154336756_+2.2207042837497e-090.4640338351716084.72295901782362e-070.3975355267631220.3190050436201640.0819126710693526
CERADediting_27969chr1_154336757_+3.24823849987764e-100.4847889657829124.86420141765419e-090.4551531959557410.4491804135016840.0622518016864612
CERADediting_27970chr1_154336769_+3.51844309260716e-100.4839533017960361.44322048334424e-090.4688088747746090.1424241584572960.120336618212089
CERADediting_27971chr1_154336850_+0.003898822119321160.2343300022277561.3059158401685e-050.3476613509361830.4831194801798850.057695351094618
CERADediting_27972chr1_154336895_+3.47240449969014e-070.4017656311433.16948660729886e-070.4030097446733070.1191309146611870.127792174691922
CERADediting_27973chr1_154336899_+1.62385262566718e-060.3799339038262825.85979518222189e-060.3604846042636120.0004850173257228760.281441238518914
CERADediting_27975chr1_154336924_+6.13001968612319e-120.5236978969887153.94962934366643e-120.5277182269619560.0001859854191267950.300578747045902
TCXADediting_27975chr1_154336924_+0.02115003431608890.1881165675715093.66462600631931e-070.4010288787911020.89803512767077-0.0105508742470053
CERADediting_27976chr1_154336929_+1.28691725910632e-070.4150310094462023.12099298274473e-100.4852060464305030.06444917599769810.151370225231328
CERADediting_27978chr1_154336936_+5.13857028124799e-070.3963653374755182.84611720818274e-080.4341611090710910.4545037939619740.0615248366050673
CERADediting_27979chr1_154336978_+9.92719955334242e-070.3870707160873770.0001649072002152670.3028888686090580.5260183195129740.0521748895014407
CERADediting_27980chr1_154336981_+1.33438486791369e-090.4696698115543752.62367724783293e-060.3728095498955310.8180138010748790.0189444066668222
DLPFCADediting_27981chr1_154337018_+1.43456550985667e-050.2436706568721440.00695312331706740.1530119111732371.05470451893549e-100.356179069533308
CERADediting_27981chr1_154337018_+1.81538692003054e-070.4104976692056134.1966409350512e-070.3991673354749260.892423777823838-0.0111349355964979

check button Correlation between ADAR gene expression and this gene's expression
TissueADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFC3.2272259222705e-360.6337278005102874.7096915873111e-330.6105489603236088.20252703203357e-220.508756397808632
AC3.15377175755211e-240.5837186670863591.36814703557493e-160.4912265604102128.30083707216033e-160.479928847167791
PCC5.73654719136309e-090.405817648705815.6887207836858e-100.4294249803060491.91203272045472e-080.392752102669586
CER6.72558331742231e-280.745837066889876.71774582147525e-440.8542877436599850.001490961659104640.257130932023492
TCX1.89714615682841e-100.4903551171532681.4863851938712e-150.5919839676105530.05800979330497860.155136418898139
FP1.02797863903278e-240.6717664572778972.27765630936819e-180.5941719417568641.97036173036755e-120.495789114714763
IFG0.0002021282253746010.6769564875347036.53813949224713e-060.7707577040823550.01355568825914090.486978555609228
PG1.35398677267079e-070.3748565137190712.21574961915114e-080.3959693561714740.01321924741703860.181394694307425
STG1.8013125901206e-100.6267368966392951.70488533034275e-050.4505396646133130.0003159970676790270.383592126361622

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Relation with AD stages for ATP8B2

check button Correlation between AD stages and RNA editing frequency
TissueADeditomIDpositionP-valCoeff.
CERADediting_27908chr1_154333383_+0.0003120738373626490.340437116335399
CERADediting_27921chr1_154335482_+9.50904491300354e-050.366647014366541
CERADediting_27930chr1_154335581_+0.000236543907915070.346755446422185
CERADediting_27940chr1_154335785_+4.9918478085071e-050.379968394875504
CERADediting_27957chr1_154336515_+0.0009660467727451270.313180847670401
CERADediting_27958chr1_154336568_+0.0007216812383240980.320460895096561
CERADediting_27975chr1_154336924_+6.66099030265729e-060.418247789582132
CERADediting_27976chr1_154336929_+0.0005179906191179270.328525145676142

check button Correlation between AD stages and this gene's expression
TissueP-valCoeff.
CER3.07949400619165e-070.468912841386418
TCX3.17661956522518e-060.434946662213351

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RelatedDrugs for ATP8B2

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ATP8B2

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource