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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited versus non-edited samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with AD stages

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene


Gene summary for TRIM54

check button Gene summary
Gene informationGene symbol

TRIM54

Gene ID

57159

Gene nametripartite motif containing 54
SynonymsMURF|MURF-3|RNF30|muRF3
Cytomap

2p23.3

Type of geneprotein-coding
Descriptiontripartite motif-containing protein 54muscle-specific RING finger protein 3ring finger protein 30
Modification date20200327
UniProtAcc

Q9BYV2,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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RNA A-to-I events for TRIM54

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_864719(27284012, +), ADediting_864720(27284048, +), ADediting_864721(27287443, +), ADediting_864722(27287657, +), ADediting_864723(27287749, +), ADediting_864724(27287750, +), ADediting_864725(27287764, +), ADediting_864726(27287781, +), ADediting_864727(27291092, +), ADediting_864728(27291096, +), ADediting_864729(27291104, +), ADediting_864730(27291120, +), ADediting_864731(27291125, +), ADediting_864732(27291129, +), ADediting_864733(27291134, +), ADediting_864734(27291178, +), ADediting_864735(27291267, +), ADediting_864736(27291270, +), ADediting_864737(27291284, +), ADediting_864738(27292427, +), ADediting_864739(27292451, +), ADediting_864740(27293767, +), ADediting_864741(27293876, +), ADediting_864742(27293908, +), ADediting_864743(27293916, +), ADediting_864744(27293929, +), ADediting_864745(27294168, +), ADediting_864746(27294198, +), ADediting_864747(27294203, +), ADediting_864748(27294229, +), ADediting_864749(27294241, +), ADediting_864750(27294256, +), ADediting_864751(27294330, +), ADediting_864752(27294356, +), ADediting_864753(27294383, +), ADediting_864754(27294395, +), ADediting_864755(27296679, +), ADediting_864756(27296876, +), ADediting_864757(27296920, +), ADediting_864758(27296939, +), ADediting_864759(27296942, +), ADediting_864760(27296959, +), ADediting_864761(27296980, +), ADediting_864762(27296981, +), ADediting_864763(27297877, +), ADediting_864764(27297901, +), ADediting_864765(27297906, +), ADediting_864766(27299531, +), ADediting_864767(27299534, +), ADediting_864768(27299572, +), ADediting_864769(27299590, +), ADediting_864770(27299611, +), ADediting_864771(27299628, +), ADediting_864772(27299644, +), ADediting_864773(27299645, +), ADediting_864774(27299832, +), ADediting_864775(27299845, +), ADediting_864776(27299947, +), ADediting_864777(27300373, +), ADediting_864778(27300693, +), ADediting_864779(27300721, +), ADediting_864780(27300745, +), ADediting_864781(27300781, +), ADediting_864782(27300786, +), ADediting_864783(27300807, +), ADediting_864784(27300897, +), ADediting_864785(27301196, +), ADediting_864786(27301217, +), ADediting_864787(27301265, +), ADediting_864788(27301279, +), ADediting_864789(27301305, +), ADediting_864790(27301306, +), ADediting_864791(27301321, +), ADediting_864792(27301323, +), ADediting_864793(27301340, +), ADediting_864794(27301349, +), ADediting_864795(27301360, +), ADediting_864796(27301383, +), ADediting_864797(27301400, +), ADediting_864798(27301402, +), ADediting_864799(27301912, +), ADediting_864800(27301913, +), ADediting_864801(27301944, +), ADediting_864802(27301972, +), ADediting_864803(27301973, +), ADediting_864804(27301978, +), ADediting_864805(27301992, +), ADediting_864806(27302007, +), ADediting_864807(27302011, +), ADediting_864808(27302133, +), ADediting_864809(27302136, +), ADediting_864810(27302219, +), ADediting_864811(27302320, +), ADediting_864812(27302559, +), ADediting_864813(27302582, +), ADediting_864814(27302592, +), ADediting_864815(27302676, +), ADediting_864816(27302680, +), ADediting_864817(27302730, +), ADediting_864818(27302743, +), ADediting_864819(27303388, +), ADediting_864820(27303389, +), ADediting_864821(27303394, +), ADediting_864822(27303430, +), ADediting_864823(27303439, +), ADediting_864824(27303447, +), ADediting_864825(27303475, +), ADediting_864826(27303491, +), ADediting_864827(27303505, +), ADediting_864828(27303958, +), ADediting_864829(27304052, +), ADediting_864830(27304053, +), ADediting_864831(27304091, +), ADediting_864832(27304132, +), ADediting_864833(27304140, +), ADediting_864834(27304316, +), ADediting_864835(27304334, +), ADediting_864836(27304335, +), ADediting_864837(27304336, +), ADediting_864838(27304344, +), ADediting_864839(27304347, +),

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RNA editing positional annotations for TRIM54 using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred
ADediting_864766chr2_27299531_+nonsynonymous SNVENST00000296098.4c.A515Gp.K172R0.2040.0-0.02
ADediting_864767chr2_27299534_+nonsynonymous SNVENST00000296098.4c.A518Gp.Q173R0.0190.607-0.11
ADediting_864768chr2_27299572_+nonsynonymous SNVENST00000296098.4c.A556Gp.T186A0.1720.0-0.14
ADediting_864769chr2_27299590_+nonsynonymous SNVENST00000296098.4c.A574Gp.S192G0.0620.003-0.12
ADediting_864770chr2_27299611_+nonsynonymous SNVENST00000296098.4c.A595Gp.S199G0.8710.682-0.08
ADediting_864771chr2_27299628_+synonymous SNVENST00000296098.4c.A612Gp.L204L...
ADediting_864772chr2_27299644_+nonsynonymous SNVENST00000296098.4c.A628Gp.K210E0.2360.003-0.12
ADediting_864773chr2_27299645_+nonsynonymous SNVENST00000296098.4c.A629Gp.K210R0.7960.005-0.08

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_864719chr2_27284012_+intronic
ADediting_864720chr2_27284048_+intronic
ADediting_864721chr2_27287443_+intronic
ADediting_864722chr2_27287657_+intronic
ADediting_864723chr2_27287749_+intronic
ADediting_864724chr2_27287750_+intronic
ADediting_864725chr2_27287764_+intronic
ADediting_864726chr2_27287781_+intronic
ADediting_864727chr2_27291092_+intronic
ADediting_864728chr2_27291096_+intronic
ADediting_864729chr2_27291104_+intronic
ADediting_864730chr2_27291120_+intronic
ADediting_864731chr2_27291125_+intronic
ADediting_864732chr2_27291129_+intronic
ADediting_864733chr2_27291134_+intronic
ADediting_864734chr2_27291178_+intronic
ADediting_864735chr2_27291267_+intronic
ADediting_864736chr2_27291270_+intronic
ADediting_864737chr2_27291284_+intronic
ADediting_864738chr2_27292427_+intronic
ADediting_864739chr2_27292451_+intronic
ADediting_864740chr2_27293767_+intronic
ADediting_864741chr2_27293876_+intronic
ADediting_864742chr2_27293908_+intronic
ADediting_864743chr2_27293916_+intronic
ADediting_864744chr2_27293929_+intronic
ADediting_864745chr2_27294168_+intronic
ADediting_864746chr2_27294198_+intronic
ADediting_864747chr2_27294203_+intronic
ADediting_864748chr2_27294229_+intronic
ADediting_864749chr2_27294241_+intronic
ADediting_864750chr2_27294256_+intronic
ADediting_864751chr2_27294330_+intronic
ADediting_864752chr2_27294356_+intronic
ADediting_864753chr2_27294383_+intronic
ADediting_864754chr2_27294395_+intronic
ADediting_864755chr2_27296679_+intronic
ADediting_864756chr2_27296876_+intronic
ADediting_864757chr2_27296920_+intronic
ADediting_864758chr2_27296939_+intronic
ADediting_864759chr2_27296942_+intronic
ADediting_864760chr2_27296959_+intronic
ADediting_864761chr2_27296980_+intronic
ADediting_864762chr2_27296981_+intronic
ADediting_864763chr2_27297877_+intronic
ADediting_864764chr2_27297901_+intronic
ADediting_864765chr2_27297906_+intronic
ADediting_864766chr2_27299531_+exonic
ADediting_864767chr2_27299534_+exonic
ADediting_864768chr2_27299572_+exonic
ADediting_864769chr2_27299590_+exonic
ADediting_864770chr2_27299611_+exonic
ADediting_864771chr2_27299628_+exonic
ADediting_864772chr2_27299644_+exonic
ADediting_864773chr2_27299645_+exonic
ADediting_864774chr2_27299832_+intronic
ADediting_864775chr2_27299845_+intronic
ADediting_864776chr2_27299947_+intronic
ADediting_864777chr2_27300373_+intronic
ADediting_864778chr2_27300693_+intronic
ADediting_864779chr2_27300721_+intronic
ADediting_864780chr2_27300745_+intronic
ADediting_864781chr2_27300781_+intronic
ADediting_864782chr2_27300786_+intronic
ADediting_864783chr2_27300807_+intronic
ADediting_864784chr2_27300897_+intronic
ADediting_864785chr2_27301196_+intronic
ADediting_864786chr2_27301217_+intronic
ADediting_864787chr2_27301265_+intronic
ADediting_864788chr2_27301279_+intronic
ADediting_864789chr2_27301305_+intronic
ADediting_864790chr2_27301306_+intronic
ADediting_864791chr2_27301321_+intronic
ADediting_864792chr2_27301323_+intronic
ADediting_864793chr2_27301340_+intronic
ADediting_864794chr2_27301349_+intronic
ADediting_864795chr2_27301360_+intronic
ADediting_864796chr2_27301383_+intronic
ADediting_864797chr2_27301400_+intronic
ADediting_864798chr2_27301402_+intronic
ADediting_864799chr2_27301912_+intronic
ADediting_864800chr2_27301913_+intronic
ADediting_864801chr2_27301944_+intronic
ADediting_864802chr2_27301972_+intronic
ADediting_864803chr2_27301973_+intronic
ADediting_864804chr2_27301978_+intronic
ADediting_864805chr2_27301992_+intronic
ADediting_864806chr2_27302007_+intronic
ADediting_864807chr2_27302011_+intronic
ADediting_864808chr2_27302133_+intronic
ADediting_864809chr2_27302136_+intronic
ADediting_864810chr2_27302219_+intronic
ADediting_864811chr2_27302320_+intronic
ADediting_864812chr2_27302559_+intronic
ADediting_864813chr2_27302582_+intronic
ADediting_864814chr2_27302592_+intronic
ADediting_864815chr2_27302676_+intronic
ADediting_864816chr2_27302680_+intronic
ADediting_864817chr2_27302730_+intronic
ADediting_864818chr2_27302743_+intronic
ADediting_864819chr2_27303388_+intronic
ADediting_864820chr2_27303389_+intronic
ADediting_864821chr2_27303394_+intronic
ADediting_864822chr2_27303430_+intronic
ADediting_864823chr2_27303439_+intronic
ADediting_864824chr2_27303447_+intronic
ADediting_864825chr2_27303475_+intronic
ADediting_864826chr2_27303491_+intronic
ADediting_864827chr2_27303505_+intronic
ADediting_864828chr2_27303958_+intronic
ADediting_864829chr2_27304052_+intronic
ADediting_864830chr2_27304053_+intronic
ADediting_864831chr2_27304091_+intronic
ADediting_864832chr2_27304132_+intronic
ADediting_864833chr2_27304140_+intronic
ADediting_864834chr2_27304316_+intronic
ADediting_864835chr2_27304334_+intronic
ADediting_864836chr2_27304335_+intronic
ADediting_864837chr2_27304336_+intronic
ADediting_864838chr2_27304344_+intronic
ADediting_864839chr2_27304347_+intronic

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_864719chr2_27284012_+SINEAluName=AluSx4
ADediting_864720chr2_27284048_+SINEAluName=AluSx4
ADediting_864721chr2_27287443_+SINEAluName=AluJb
ADediting_864722chr2_27287657_+SINEAluName=AluJr4
ADediting_864723chr2_27287749_+SINEAluName=AluJr4
ADediting_864724chr2_27287750_+SINEAluName=AluJr4
ADediting_864725chr2_27287764_+SINEAluName=AluJr4
ADediting_864726chr2_27287781_+SINEAluName=AluJr4
ADediting_864727chr2_27291092_+SINEAluName=AluSq
ADediting_864728chr2_27291096_+SINEAluName=AluSq
ADediting_864729chr2_27291104_+SINEAluName=AluSq
ADediting_864730chr2_27291120_+SINEAluName=AluSq
ADediting_864731chr2_27291125_+SINEAluName=AluSq
ADediting_864732chr2_27291129_+SINEAluName=AluSq
ADediting_864733chr2_27291134_+SINEAluName=AluSq
ADediting_864734chr2_27291178_+SINEAluName=AluSq
ADediting_864735chr2_27291267_+SINEAluName=AluSq
ADediting_864736chr2_27291270_+SINEAluName=AluSq
ADediting_864737chr2_27291284_+SINEAluName=AluSq
ADediting_864738chr2_27292427_+SINEAluName=AluJr
ADediting_864739chr2_27292451_+SINEAluName=AluJr
ADediting_864740chr2_27293767_+SINEAluName=AluSx
ADediting_864741chr2_27293876_+SINEAluName=AluSx
ADediting_864742chr2_27293908_+SINEAluName=AluSx
ADediting_864743chr2_27293916_+SINEAluName=AluSx
ADediting_864744chr2_27293929_+SINEAluName=AluSx
ADediting_864745chr2_27294168_+SINEAluName=AluJb
ADediting_864746chr2_27294198_+SINEAluName=AluJb
ADediting_864747chr2_27294203_+SINEAluName=AluJb
ADediting_864748chr2_27294229_+SINEAluName=AluJb
ADediting_864749chr2_27294241_+SINEAluName=AluJb
ADediting_864750chr2_27294256_+SINEAluName=AluJb
ADediting_864751chr2_27294330_+SINEAluName=AluJb
ADediting_864752chr2_27294356_+SINEAluName=AluJb
ADediting_864753chr2_27294383_+SINEAluName=AluJb
ADediting_864754chr2_27294395_+SINEAluName=AluJb
ADediting_864755chr2_27296679_+LTRERVL-MaLRName=MLT1J
ADediting_864756chr2_27296876_+SINEAluName=AluSz
ADediting_864757chr2_27296920_+SINEAluName=AluSz
ADediting_864758chr2_27296939_+SINEAluName=AluSz
ADediting_864759chr2_27296942_+SINEAluName=AluSz
ADediting_864760chr2_27296959_+SINEAluName=AluSz
ADediting_864761chr2_27296980_+SINEAluName=AluSz
ADediting_864762chr2_27296981_+SINEAluName=AluSz
ADediting_864763chr2_27297877_+SINEAluName=AluJr
ADediting_864764chr2_27297901_+SINEAluName=AluJr
ADediting_864765chr2_27297906_+SINEAluName=AluJr
ADediting_864766chr2_27299531_+SINEAluName=AluJb
ADediting_864767chr2_27299534_+SINEAluName=AluJb
ADediting_864768chr2_27299572_+SINEAluName=AluJb
ADediting_864769chr2_27299590_+SINEAluName=AluJb
ADediting_864770chr2_27299611_+SINEAluName=AluJb
ADediting_864771chr2_27299628_+SINEAluName=AluJb
ADediting_864772chr2_27299644_+SINEAluName=AluJb
ADediting_864773chr2_27299645_+SINEAluName=AluJb
ADediting_864774chr2_27299832_+SINEAluName=AluSz6
ADediting_864775chr2_27299845_+SINEAluName=AluSz6
ADediting_864776chr2_27299947_+SINEAluName=AluSz6
ADediting_864777chr2_27300373_+SINEAluName=AluSq2
ADediting_864778chr2_27300693_+SINEAluName=AluJb
ADediting_864779chr2_27300721_+SINEAluName=AluJb
ADediting_864780chr2_27300745_+SINEAluName=AluJb
ADediting_864781chr2_27300781_+SINEAluName=AluJb
ADediting_864782chr2_27300786_+SINEAluName=AluJb
ADediting_864783chr2_27300807_+SINEAluName=AluJb
ADediting_864784chr2_27300897_+SINEAluName=AluJo
ADediting_864785chr2_27301196_+SINEAluName=AluSq2
ADediting_864786chr2_27301217_+SINEAluName=AluSq2
ADediting_864787chr2_27301265_+SINEAluName=AluSq2
ADediting_864788chr2_27301279_+SINEAluName=AluSq2
ADediting_864789chr2_27301305_+SINEAluName=AluSq2
ADediting_864790chr2_27301306_+SINEAluName=AluSq2
ADediting_864791chr2_27301321_+SINEAluName=AluSq2
ADediting_864792chr2_27301323_+SINEAluName=AluSq2
ADediting_864793chr2_27301340_+SINEAluName=AluSq2
ADediting_864794chr2_27301349_+SINEAluName=AluSq2
ADediting_864795chr2_27301360_+SINEAluName=AluSq2
ADediting_864796chr2_27301383_+SINEAluName=AluSq2
ADediting_864797chr2_27301400_+SINEAluName=AluSq2
ADediting_864798chr2_27301402_+SINEAluName=AluSq2
ADediting_864799chr2_27301912_+SINEAluName=AluSq2
ADediting_864800chr2_27301913_+SINEAluName=AluSq2
ADediting_864801chr2_27301944_+SINEAluName=AluSq2
ADediting_864802chr2_27301972_+SINEAluName=AluSq2
ADediting_864803chr2_27301973_+SINEAluName=AluSq2
ADediting_864804chr2_27301978_+SINEAluName=AluSq2
ADediting_864805chr2_27301992_+SINEAluName=AluSq2
ADediting_864806chr2_27302007_+SINEAluName=AluSq2
ADediting_864807chr2_27302011_+SINEAluName=AluSq2
ADediting_864808chr2_27302133_+SINEAluName=AluSq2
ADediting_864809chr2_27302136_+SINEAluName=AluSq2
ADediting_864810chr2_27302219_+SINEAluName=AluY
ADediting_864811chr2_27302320_+SINEAluName=AluY
ADediting_864812chr2_27302559_+SINEAluName=AluSq2
ADediting_864813chr2_27302582_+SINEAluName=AluSq2
ADediting_864814chr2_27302592_+SINEAluName=AluSq2
ADediting_864815chr2_27302676_+SINEAluName=AluSq2
ADediting_864816chr2_27302680_+SINEAluName=AluSq2
ADediting_864817chr2_27302730_+SINEAluName=AluSq2
ADediting_864818chr2_27302743_+SINEAluName=AluSq2
ADediting_864819chr2_27303388_+SINEAluName=AluSx3
ADediting_864820chr2_27303389_+SINEAluName=AluSx3
ADediting_864821chr2_27303394_+SINEAluName=AluSx3
ADediting_864822chr2_27303430_+SINEAluName=AluSx3
ADediting_864823chr2_27303439_+SINEAluName=AluSx3
ADediting_864824chr2_27303447_+SINEAluName=AluSx3
ADediting_864825chr2_27303475_+SINEAluName=AluSx3
ADediting_864826chr2_27303491_+SINEAluName=AluSx3
ADediting_864827chr2_27303505_+SINEAluName=AluSx3
ADediting_864828chr2_27303958_+SINEAluName=AluJb
ADediting_864829chr2_27304052_+SINEAluName=AluJb
ADediting_864830chr2_27304053_+SINEAluName=AluJb
ADediting_864831chr2_27304091_+SINEAluName=AluJb
ADediting_864832chr2_27304132_+SINEAluName=AluJb
ADediting_864833chr2_27304140_+SINEAluName=AluJb
ADediting_864834chr2_27304316_+SINEAluName=AluJr4
ADediting_864835chr2_27304334_+SINEAluName=AluJr4
ADediting_864836chr2_27304335_+SINEAluName=AluJr4
ADediting_864837chr2_27304336_+SINEAluName=AluJr4
ADediting_864838chr2_27304344_+SINEAluName=AluJr4
ADediting_864839chr2_27304347_+SINEAluName=AluJr4

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RNA A-to-I editing events in the alternative splicing sites for TRIM54

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength
ESADediting_864766chr2_27299531_+27299510:272995323ss2eTTATTTCTTTATTTATTTAGAAA7.02TTATTTCTTTATTTATTTAGAGA6.69

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for TRIM54

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
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check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
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check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
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ADeditome IDChrPositoingSkipped exonENSGENSTs

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Protein coding region RNA A-to-I editings for TRIM54

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.
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The effects of the RNA editing to the miRNA binding sites for TRIM54


check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1337758chr7_5495892_-ENSG00000138100.13ENST00000296098.4TRIM54-201hsa-miR-589-5pchr227307352273073598mer-1a2730733927307359146-20.61
ADediting_1337758chr7_5495892_-ENSG00000138100.13ENST00000380075.6TRIM54-202hsa-miR-589-5pchr227307352273073598mer-1a2730733927307359146-20.61

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for TRIM54

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.
ENST00000296098.4protein_codingSoverviewSoverview

check button RNA A-to-I editing in miRNA.
ADeditom_IDENSTmir_IDEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in mRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI
ADediting_864766ENST00000296098.4chr2_27299531_+785-809.50-809.70-813.50
ADediting_864767ENST00000296098.4chr2_27299534_+788-809.00-809.70-813.50
ADediting_864768ENST00000296098.4chr2_27299572_+826-809.80-809.70-813.50
ADediting_864769ENST00000296098.4chr2_27299590_+844-810.10-809.70-813.50
ADediting_864770ENST00000296098.4chr2_27299611_+865-809.40-809.70-813.50
ADediting_864771ENST00000296098.4chr2_27299628_+882-809.90-809.70-813.50
ADediting_864772ENST00000296098.4chr2_27299644_+898-808.90-809.70-813.50
ADediting_864773ENST00000296098.4chr2_27299645_+899-810.60-809.70-813.50

check button RNA A-to-I editing in lncRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for TRIM54

check button Correlation between ADAR gene expression and RNA editing frequency
TissueADeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFCADediting_864767chr2_27299534_+8.98191068768105e-050.2205908971224933.27629598637728e-080.3074622691870510.65478327952886-0.025493975212893
DLPFCADediting_864768chr2_27299572_+4.54361774029606e-050.2294412022654452.72881559668846e-090.3296197208723060.2601716435116460.0641449306391429
DLPFCADediting_864770chr2_27299611_+1.13480826470186e-050.2464602134412531.37851872150191e-080.3153865828004210.004660476619313580.160317925264292
DLPFCADediting_864771chr2_27299628_+4.44790152670866e-050.2297121621883741.32399687567467e-090.3357450354695880.01020176492050620.14571364209736
DLPFCADediting_864775chr2_27299845_+0.0002091322496862590.20909669246330.02673835538454160.1258293479757791.16155146074334e-110.372877292844643
DLPFCADediting_864797chr2_27301400_+1.66235724576358e-050.2418996505890520.01909129663199350.1330607774202752.5589380674776e-160.442812504725749
DLPFCADediting_864799chr2_27301912_+2.35529875941682e-050.2376582704437780.03247194049072320.1215021061304425.18288588244482e-100.34349351819309
DLPFCADediting_864800chr2_27301913_+0.0006890528931057660.1917434621146850.2372434396695770.06732347335159674.82514562983521e-120.379268198079428
DLPFCADediting_864810chr2_27302219_+0.01876342676901640.1334239408075450.3900427019822910.0489871673573368.71622046331113e-120.37498172094761

check button Correlation between ADAR gene expression and this gene's expression
TissueADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFC9.28173954844321e-140.4064111453684312.50013897814746e-250.544506097194048.37874893254135e-060.250022194082861
PCC1.75727393216668e-150.5341319083479593.55350563588278e-180.5746360505674970.004527959499653590.204576287707849
TCX0.1850012949813210.1088162525049312.56429239379164e-050.3364118459900862.33874510002867e-05-0.33797257758141
FP2.46381493068557e-160.5639725037042279.6860136596648e-110.4607618415315410.04308376540224230.151812131197043
IFG0.0005494330120816660.6414078745599680.001513878759229840.6002232872662720.3731829431369910.186068897645691
PG1.13560738149518e-050.3157183826600353.70840952592106e-110.4606175451694830.0459408599609442-0.14654598522559
STG4.45871756523073e-080.554418118867243.27525725153353e-090.5909045957472740.8811545123527230.0165594314118481

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Relation with AD stages for TRIM54

check button Correlation between AD stages and RNA editing frequency
TissueADeditomIDpositionP-valCoeff.

check button Correlation between AD stages and this gene's expression
TissueP-valCoeff.

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RelatedDrugs for TRIM54

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TRIM54

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource