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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for HTRA1 |
 Gene summary |
| Gene information | Gene symbol | HTRA1 | Gene ID | 5654 |
| Gene name | HtrA serine peptidase 1 | |
| Synonyms | ARMD7|CADASIL2|CARASIL|HtrA|L56|ORF480|PRSS11 | |
| Cytomap | 10q26.13 | |
| Type of gene | protein-coding | |
| Description | serine protease HTRA1IGFBP5-proteasehigh-temperature requirement A serine peptidase 1protease, serine, 11 (IGF binding) | |
| Modification date | 20200322 | |
| UniProtAcc | Q92743, | |
| Context | - 31603204(Rs2293871 regulates HTRA1 expression and affects cerebral small vessel stroke and Alzheimer's disease) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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RNA A-to-I events for HTRA1 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_171024(122466305, +), ADediting_171025(122466374, +), ADediting_171026(122472457, +), ADediting_171027(122472482, +), ADediting_171028(122472489, +), ADediting_171029(122472496, +), ADediting_171030(122472499, +), ADediting_171031(122472657, +), ADediting_171032(122477214, +), ADediting_171033(122477229, +), ADediting_171034(122482664, +), ADediting_171035(122482695, +), ADediting_171036(122482711, +), ADediting_171037(122482732, +), ADediting_171038(122482742, +), ADediting_171039(122482747, +), ADediting_171040(122513563, +), ADediting_171041(122513564, +), ADediting_1522712(122472675, +), ADediting_1522713(122511108, +), |
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RNA editing positional annotations for HTRA1 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_171024 | chr10_122466305_+ | intronic |
| ADediting_171025 | chr10_122466374_+ | intronic |
| ADediting_171026 | chr10_122472457_+ | intronic |
| ADediting_171027 | chr10_122472482_+ | intronic |
| ADediting_171028 | chr10_122472489_+ | intronic |
| ADediting_171029 | chr10_122472496_+ | intronic |
| ADediting_171030 | chr10_122472499_+ | intronic |
| ADediting_171031 | chr10_122472657_+ | intronic |
| ADediting_171032 | chr10_122477214_+ | intronic |
| ADediting_171033 | chr10_122477229_+ | intronic |
| ADediting_171034 | chr10_122482664_+ | intronic |
| ADediting_171035 | chr10_122482695_+ | intronic |
| ADediting_171036 | chr10_122482711_+ | intronic |
| ADediting_171037 | chr10_122482732_+ | intronic |
| ADediting_171038 | chr10_122482742_+ | intronic |
| ADediting_171039 | chr10_122482747_+ | intronic |
| ADediting_171040 | chr10_122513563_+ | intronic |
| ADediting_171041 | chr10_122513564_+ | intronic |
| ADediting_1522712 | chr10_122472675_+ | intronic |
| ADediting_1522713 | chr10_122511108_+ | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_171024 | chr10_122466305_+ | SINE | Alu | Name=AluY |
| ADediting_171025 | chr10_122466374_+ | SINE | Alu | Name=AluY |
| ADediting_171026 | chr10_122472457_+ | SINE | Alu | Name=AluSz6 |
| ADediting_171027 | chr10_122472482_+ | SINE | Alu | Name=AluSz6 |
| ADediting_171028 | chr10_122472489_+ | SINE | Alu | Name=AluSz6 |
| ADediting_171029 | chr10_122472496_+ | SINE | Alu | Name=AluSz6 |
| ADediting_171030 | chr10_122472499_+ | SINE | Alu | Name=AluSz6 |
| ADediting_171031 | chr10_122472657_+ | SINE | Alu | Name=AluSz6 |
| ADediting_171032 | chr10_122477214_+ | SINE | Alu | Name=AluY |
| ADediting_171033 | chr10_122477229_+ | SINE | Alu | Name=AluY |
| ADediting_171034 | chr10_122482664_+ | SINE | Alu | Name=AluSg |
| ADediting_171035 | chr10_122482695_+ | SINE | Alu | Name=AluSg |
| ADediting_171036 | chr10_122482711_+ | SINE | Alu | Name=AluSg |
| ADediting_171037 | chr10_122482732_+ | SINE | Alu | Name=AluSg |
| ADediting_171038 | chr10_122482742_+ | SINE | Alu | Name=AluSg |
| ADediting_171039 | chr10_122482747_+ | SINE | Alu | Name=AluSg |
| ADediting_171040 | chr10_122513563_+ | SINE | Alu | Name=FLAM_C |
| ADediting_171041 | chr10_122513564_+ | SINE | Alu | Name=FLAM_C |
| ADediting_1522712 | chr10_122472675_+ | SINE | Alu | Name=AluSz6 |
| ADediting_1522713 | chr10_122511108_+ | SINE | MIR | Name=MIR |
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RNA A-to-I editing events in the alternative splicing sites for HTRA1 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for HTRA1 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for HTRA1 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for HTRA1 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000166033.13 | ENST00000368984.8 | HTRA1-201 | hsa-miR-5688 | chr10 | 122514469 | 122514475 | 7mer-m8 | 122514455 | 122514476 | 145 | -9.08 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000166033.13 | ENST00000420892.1 | HTRA1-202 | hsa-miR-5688 | chr10 | 122514469 | 122514475 | 7mer-m8 | 122514455 | 122514476 | 145 | -9.08 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000166033.13 | ENST00000648167.1 | HTRA1-203 | hsa-miR-5688 | chr10 | 122514469 | 122514475 | 7mer-m8 | 122514455 | 122514476 | 145 | -9.08 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for HTRA1 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for HTRA1 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| TCX | ADediting_171028 | chr10_122472489_+ | 0.615015358342438 | 0.0413925065214418 | 0.0420953037420924 | -0.166193504556593 | 4.73318709466382e-06 | 0.363809565738299 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| AC | 2.07328579754635e-31 | 0.650039439384269 | 9.99296056871881e-18 | 0.506915916373343 | 3.20415165629363e-28 | 0.622521115811037 |
| CER | 0.959923649260662 | 0.00413744015294482 | 0.0231157238408205 | -0.185408465798068 | 6.98250417981382e-08 | 0.422926291217067 |
| TCX | 0.00695832733392422 | 0.219500884716883 | 0.00295194548345392 | -0.241144693456215 | 2.61491902381358e-13 | 0.551436795363855 |
| FP | 7.0161901562051e-11 | 0.463817280639309 | 7.57759852287078e-08 | 0.389713024574214 | 3.79942877904085e-11 | 0.469547091008484 |
| IFG | 0.0183384243005821 | 0.467902578438918 | 0.468693075887978 | 0.151851972196108 | 0.0281812671495158 | 0.43887407344359 |
| PG | 4.90465189644246e-30 | 0.711741783077281 | 1.39746338457558e-08 | 0.401117172463997 | 0.00290485419372789 | 0.217182506759154 |
| STG | 3.59551124590338e-14 | 0.710830395331187 | 1.42359533480595e-05 | 0.454246754002892 | 0.000386575704314929 | 0.378402049684105 |
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Relation with AD stages for HTRA1 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| TCX | 1.81988229338273e-05 | 0.403248092705532 |
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RelatedDrugs for HTRA1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for HTRA1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| HTRA1 | C0024121 | Lung Neoplasms | 1 | CTD_human |
| HTRA1 | C0242379 | Malignant neoplasm of lung | 1 | CTD_human |
| HTRA1 | C1838577 | Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy | 1 | CTD_human;ORPHANET;UNIPROT |
| HTRA1 | C4225211 | CEREBRAL ARTERIOPATHY, AUTOSOMAL DOMINANT, WITH SUBCORTICAL INFARCTS AND LEUKOENCEPHALOPATHY, TYPE 2 | 1 | UNIPROT |
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