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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for UNC45A |
 Gene summary |
| Gene information | Gene symbol | UNC45A | Gene ID | 55898 |
| Gene name | unc-45 myosin chaperone A | |
| Synonyms | GC-UNC45|GCUNC-45|GCUNC45|IRO039700|SMAP-1|SMAP1|UNC-45A | |
| Cytomap | 15q26.1 | |
| Type of gene | protein-coding | |
| Description | protein unc-45 homolog Ageneral cell UNC45smooth muscle cell associated protein-1unc-45 homolog A | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
Top |
RNA A-to-I events for UNC45A |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_511230(90937112, +), ADediting_511231(90937113, +), ADediting_511232(90937136, +), ADediting_511233(90937164, +), ADediting_511234(90937185, +), ADediting_511235(90937186, +), ADediting_511236(90937225, +), ADediting_511237(90937235, +), ADediting_511238(90937242, +), ADediting_511239(90937252, +), ADediting_511240(90937285, +), ADediting_511241(90937537, +), ADediting_511242(90937587, +), ADediting_511243(90937616, +), ADediting_511244(90937668, +), ADediting_511245(90943213, +), ADediting_511246(90943245, +), ADediting_511247(90943282, +), ADediting_511248(90943302, +), ADediting_511249(90943323, +), ADediting_511250(90943341, +), ADediting_511251(90943344, +), ADediting_511252(90943348, +), ADediting_511253(90943349, +), ADediting_511254(90943358, +), ADediting_511255(90943363, +), ADediting_511256(90943374, +), ADediting_511257(90943397, +), ADediting_511258(90943408, +), ADediting_511259(90943409, +), ADediting_511260(90943571, +), ADediting_511261(90943739, +), ADediting_511262(90943758, +), ADediting_511263(90943763, +), ADediting_511264(90943788, +), ADediting_511265(90943789, +), ADediting_511266(90943792, +), ADediting_511267(90943793, +), ADediting_511268(90943794, +), ADediting_511269(90943828, +), ADediting_511270(90943834, +), ADediting_511271(90943854, +), ADediting_511272(90943863, +), ADediting_511273(90943872, +), ADediting_511274(90943878, +), ADediting_511275(90943881, +), ADediting_511276(90943886, +), ADediting_511277(90943889, +), ADediting_511278(90943898, +), ADediting_511279(90943951, +), ADediting_511280(90943969, +), ADediting_511281(90944129, +), ADediting_511282(90944131, +), ADediting_511283(90944132, +), ADediting_511284(90944137, +), ADediting_511285(90944175, +), ADediting_511286(90944189, +), ADediting_511287(90944223, +), ADediting_511288(90944244, +), ADediting_511289(90944260, +), ADediting_511290(90944267, +), ADediting_511291(90944308, +), ADediting_511292(90944312, +), ADediting_511293(90944328, +), ADediting_511294(90945439, +), ADediting_511295(90945462, +), ADediting_511296(90945685, +), ADediting_511297(90945726, +), ADediting_511298(90945732, +), ADediting_511299(90945733, +), ADediting_511300(90945736, +), ADediting_511301(90945759, +), ADediting_511302(90945762, +), ADediting_511303(90945771, +), ADediting_511304(90945816, +), ADediting_511305(90945902, +), ADediting_511306(90946043, +), ADediting_511307(90947046, +), ADediting_511308(90947104, +), ADediting_511309(90951029, +), ADediting_511310(90951051, +), ADediting_511311(90951056, +), ADediting_511312(90951108, +), ADediting_511313(90951204, +), ADediting_511314(90951267, +), ADediting_511315(90951279, +), ADediting_511316(90951534, +), ADediting_511317(90951791, +), ADediting_511318(90951797, +), ADediting_511319(90951807, +), ADediting_511320(90951820, +), ADediting_511321(90951824, +), ADediting_511322(90951833, +), ADediting_511323(90951838, +), ADediting_511324(90951863, +), ADediting_511325(90951897, +), ADediting_1540826(90937626, +), ADediting_1540827(90938025, +), ADediting_1540828(90938049, +), ADediting_1540829(90951027, +), ADediting_1540830(90951107, +), ADediting_1540831(90951125, +), ADediting_1540832(90951499, +), ADediting_1540833(90951517, +), ADediting_1540834(90951892, +), ADediting_1623616(90949016, +), |
Top |
RNA editing positional annotations for UNC45A using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_511230 | chr15_90937112_+ | intronic |
| ADediting_511231 | chr15_90937113_+ | intronic |
| ADediting_511232 | chr15_90937136_+ | intronic |
| ADediting_511233 | chr15_90937164_+ | intronic |
| ADediting_511234 | chr15_90937185_+ | intronic |
| ADediting_511235 | chr15_90937186_+ | intronic |
| ADediting_511236 | chr15_90937225_+ | intronic |
| ADediting_511237 | chr15_90937235_+ | intronic |
| ADediting_511238 | chr15_90937242_+ | intronic |
| ADediting_511239 | chr15_90937252_+ | intronic |
| ADediting_511240 | chr15_90937285_+ | intronic |
| ADediting_511241 | chr15_90937537_+ | intronic |
| ADediting_511242 | chr15_90937587_+ | intronic |
| ADediting_511243 | chr15_90937616_+ | intronic |
| ADediting_511244 | chr15_90937668_+ | intronic |
| ADediting_511245 | chr15_90943213_+ | intronic |
| ADediting_511246 | chr15_90943245_+ | intronic |
| ADediting_511247 | chr15_90943282_+ | intronic |
| ADediting_511248 | chr15_90943302_+ | intronic |
| ADediting_511249 | chr15_90943323_+ | intronic |
| ADediting_511250 | chr15_90943341_+ | intronic |
| ADediting_511251 | chr15_90943344_+ | intronic |
| ADediting_511252 | chr15_90943348_+ | intronic |
| ADediting_511253 | chr15_90943349_+ | intronic |
| ADediting_511254 | chr15_90943358_+ | intronic |
| ADediting_511255 | chr15_90943363_+ | intronic |
| ADediting_511256 | chr15_90943374_+ | intronic |
| ADediting_511257 | chr15_90943397_+ | intronic |
| ADediting_511258 | chr15_90943408_+ | intronic |
| ADediting_511259 | chr15_90943409_+ | intronic |
| ADediting_511260 | chr15_90943571_+ | intronic |
| ADediting_511261 | chr15_90943739_+ | intronic |
| ADediting_511262 | chr15_90943758_+ | intronic |
| ADediting_511263 | chr15_90943763_+ | intronic |
| ADediting_511264 | chr15_90943788_+ | intronic |
| ADediting_511265 | chr15_90943789_+ | intronic |
| ADediting_511266 | chr15_90943792_+ | intronic |
| ADediting_511267 | chr15_90943793_+ | intronic |
| ADediting_511268 | chr15_90943794_+ | intronic |
| ADediting_511269 | chr15_90943828_+ | intronic |
| ADediting_511270 | chr15_90943834_+ | intronic |
| ADediting_511271 | chr15_90943854_+ | intronic |
| ADediting_511272 | chr15_90943863_+ | intronic |
| ADediting_511273 | chr15_90943872_+ | intronic |
| ADediting_511274 | chr15_90943878_+ | intronic |
| ADediting_511275 | chr15_90943881_+ | intronic |
| ADediting_511276 | chr15_90943886_+ | intronic |
| ADediting_511277 | chr15_90943889_+ | intronic |
| ADediting_511278 | chr15_90943898_+ | intronic |
| ADediting_511279 | chr15_90943951_+ | intronic |
| ADediting_511280 | chr15_90943969_+ | intronic |
| ADediting_511281 | chr15_90944129_+ | intronic |
| ADediting_511282 | chr15_90944131_+ | intronic |
| ADediting_511283 | chr15_90944132_+ | intronic |
| ADediting_511284 | chr15_90944137_+ | intronic |
| ADediting_511285 | chr15_90944175_+ | intronic |
| ADediting_511286 | chr15_90944189_+ | intronic |
| ADediting_511287 | chr15_90944223_+ | intronic |
| ADediting_511288 | chr15_90944244_+ | intronic |
| ADediting_511289 | chr15_90944260_+ | intronic |
| ADediting_511290 | chr15_90944267_+ | intronic |
| ADediting_511291 | chr15_90944308_+ | intronic |
| ADediting_511292 | chr15_90944312_+ | intronic |
| ADediting_511293 | chr15_90944328_+ | intronic |
| ADediting_511294 | chr15_90945439_+ | intronic |
| ADediting_511295 | chr15_90945462_+ | intronic |
| ADediting_511296 | chr15_90945685_+ | intronic |
| ADediting_511297 | chr15_90945726_+ | intronic |
| ADediting_511298 | chr15_90945732_+ | intronic |
| ADediting_511299 | chr15_90945733_+ | intronic |
| ADediting_511300 | chr15_90945736_+ | intronic |
| ADediting_511301 | chr15_90945759_+ | intronic |
| ADediting_511302 | chr15_90945762_+ | intronic |
| ADediting_511303 | chr15_90945771_+ | intronic |
| ADediting_511304 | chr15_90945816_+ | intronic |
| ADediting_511305 | chr15_90945902_+ | intronic |
| ADediting_511306 | chr15_90946043_+ | intronic |
| ADediting_511307 | chr15_90947046_+ | intronic |
| ADediting_511308 | chr15_90947104_+ | intronic |
| ADediting_511309 | chr15_90951029_+ | intronic |
| ADediting_511310 | chr15_90951051_+ | intronic |
| ADediting_511311 | chr15_90951056_+ | intronic |
| ADediting_511312 | chr15_90951108_+ | intronic |
| ADediting_511313 | chr15_90951204_+ | intronic |
| ADediting_511314 | chr15_90951267_+ | intronic |
| ADediting_511315 | chr15_90951279_+ | intronic |
| ADediting_511316 | chr15_90951534_+ | intronic |
| ADediting_511317 | chr15_90951791_+ | intronic |
| ADediting_511318 | chr15_90951797_+ | intronic |
| ADediting_511319 | chr15_90951807_+ | intronic |
| ADediting_511320 | chr15_90951820_+ | intronic |
| ADediting_511321 | chr15_90951824_+ | intronic |
| ADediting_511322 | chr15_90951833_+ | intronic |
| ADediting_511323 | chr15_90951838_+ | intronic |
| ADediting_511324 | chr15_90951863_+ | intronic |
| ADediting_511325 | chr15_90951897_+ | intronic |
| ADediting_1540826 | chr15_90937626_+ | intronic |
| ADediting_1540827 | chr15_90938025_+ | intronic |
| ADediting_1540828 | chr15_90938049_+ | intronic |
| ADediting_1540829 | chr15_90951027_+ | intronic |
| ADediting_1540830 | chr15_90951107_+ | intronic |
| ADediting_1540831 | chr15_90951125_+ | intronic |
| ADediting_1540832 | chr15_90951499_+ | intronic |
| ADediting_1540833 | chr15_90951517_+ | intronic |
| ADediting_1540834 | chr15_90951892_+ | intronic |
| ADediting_1623616 | chr15_90949016_+ | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_511230 | chr15_90937112_+ | SINE | Alu | Name=AluJr4 |
| ADediting_511231 | chr15_90937113_+ | SINE | Alu | Name=AluJr4 |
| ADediting_511232 | chr15_90937136_+ | SINE | Alu | Name=AluJr4 |
| ADediting_511233 | chr15_90937164_+ | SINE | Alu | Name=AluJr4 |
| ADediting_511234 | chr15_90937185_+ | SINE | Alu | Name=AluJr4 |
| ADediting_511235 | chr15_90937186_+ | SINE | Alu | Name=AluJr4 |
| ADediting_511236 | chr15_90937225_+ | SINE | Alu | Name=AluJr4 |
| ADediting_511237 | chr15_90937235_+ | SINE | Alu | Name=AluJr4 |
| ADediting_511238 | chr15_90937242_+ | SINE | Alu | Name=AluJr4 |
| ADediting_511239 | chr15_90937252_+ | SINE | Alu | Name=AluJr4 |
| ADediting_511240 | chr15_90937285_+ | SINE | Alu | Name=AluJr4 |
| ADediting_511241 | chr15_90937537_+ | SINE | Alu | Name=AluSc8 |
| ADediting_511242 | chr15_90937587_+ | SINE | Alu | Name=AluSc8 |
| ADediting_511243 | chr15_90937616_+ | SINE | Alu | Name=AluSc8 |
| ADediting_511244 | chr15_90937668_+ | SINE | Alu | Name=AluSc8 |
| ADediting_511245 | chr15_90943213_+ | SINE | Alu | Name=AluJr |
| ADediting_511246 | chr15_90943245_+ | SINE | Alu | Name=AluJr |
| ADediting_511247 | chr15_90943282_+ | SINE | Alu | Name=AluJr |
| ADediting_511248 | chr15_90943302_+ | SINE | Alu | Name=AluJr |
| ADediting_511249 | chr15_90943323_+ | SINE | Alu | Name=AluJr |
| ADediting_511250 | chr15_90943341_+ | SINE | Alu | Name=AluJr |
| ADediting_511251 | chr15_90943344_+ | SINE | Alu | Name=AluJr |
| ADediting_511252 | chr15_90943348_+ | SINE | Alu | Name=AluJr |
| ADediting_511253 | chr15_90943349_+ | SINE | Alu | Name=AluJr |
| ADediting_511254 | chr15_90943358_+ | SINE | Alu | Name=AluJr |
| ADediting_511255 | chr15_90943363_+ | SINE | Alu | Name=AluJr |
| ADediting_511256 | chr15_90943374_+ | SINE | Alu | Name=AluJr |
| ADediting_511257 | chr15_90943397_+ | SINE | Alu | Name=AluJr |
| ADediting_511258 | chr15_90943408_+ | SINE | Alu | Name=AluJr |
| ADediting_511259 | chr15_90943409_+ | SINE | Alu | Name=AluJr |
| ADediting_511261 | chr15_90943739_+ | SINE | Alu | Name=AluSz |
| ADediting_511262 | chr15_90943758_+ | SINE | Alu | Name=AluSz |
| ADediting_511263 | chr15_90943763_+ | SINE | Alu | Name=AluSz |
| ADediting_511264 | chr15_90943788_+ | SINE | Alu | Name=AluSz |
| ADediting_511265 | chr15_90943789_+ | SINE | Alu | Name=AluSz |
| ADediting_511266 | chr15_90943792_+ | SINE | Alu | Name=AluSz |
| ADediting_511267 | chr15_90943793_+ | SINE | Alu | Name=AluSz |
| ADediting_511268 | chr15_90943794_+ | SINE | Alu | Name=AluSz |
| ADediting_511269 | chr15_90943828_+ | SINE | Alu | Name=AluSz |
| ADediting_511270 | chr15_90943834_+ | SINE | Alu | Name=AluSz |
| ADediting_511271 | chr15_90943854_+ | SINE | Alu | Name=AluSz |
| ADediting_511272 | chr15_90943863_+ | SINE | Alu | Name=AluSz |
| ADediting_511273 | chr15_90943872_+ | SINE | Alu | Name=AluSz |
| ADediting_511274 | chr15_90943878_+ | SINE | Alu | Name=AluSz |
| ADediting_511275 | chr15_90943881_+ | SINE | Alu | Name=AluSz |
| ADediting_511276 | chr15_90943886_+ | SINE | Alu | Name=AluSz |
| ADediting_511277 | chr15_90943889_+ | SINE | Alu | Name=AluSz |
| ADediting_511278 | chr15_90943898_+ | SINE | Alu | Name=AluSz |
| ADediting_511279 | chr15_90943951_+ | SINE | Alu | Name=AluSz |
| ADediting_511280 | chr15_90943969_+ | SINE | Alu | Name=AluSz |
| ADediting_511281 | chr15_90944129_+ | SINE | Alu | Name=AluSx3 |
| ADediting_511282 | chr15_90944131_+ | SINE | Alu | Name=AluSx3 |
| ADediting_511283 | chr15_90944132_+ | SINE | Alu | Name=AluSx3 |
| ADediting_511284 | chr15_90944137_+ | SINE | Alu | Name=AluSx3 |
| ADediting_511285 | chr15_90944175_+ | SINE | Alu | Name=AluSx3 |
| ADediting_511286 | chr15_90944189_+ | SINE | Alu | Name=AluSx3 |
| ADediting_511287 | chr15_90944223_+ | SINE | Alu | Name=AluSx3 |
| ADediting_511288 | chr15_90944244_+ | SINE | Alu | Name=AluSx3 |
| ADediting_511289 | chr15_90944260_+ | SINE | Alu | Name=AluSx3 |
| ADediting_511290 | chr15_90944267_+ | SINE | Alu | Name=AluSx3 |
| ADediting_511291 | chr15_90944308_+ | SINE | Alu | Name=AluSx3 |
| ADediting_511292 | chr15_90944312_+ | SINE | Alu | Name=AluSx3 |
| ADediting_511293 | chr15_90944328_+ | SINE | Alu | Name=AluSx3 |
| ADediting_511294 | chr15_90945439_+ | SINE | Alu | Name=AluSp |
| ADediting_511295 | chr15_90945462_+ | SINE | Alu | Name=AluSp |
| ADediting_511296 | chr15_90945685_+ | SINE | Alu | Name=AluSq2 |
| ADediting_511297 | chr15_90945726_+ | SINE | Alu | Name=AluSq2 |
| ADediting_511298 | chr15_90945732_+ | SINE | Alu | Name=AluSq2 |
| ADediting_511299 | chr15_90945733_+ | SINE | Alu | Name=AluSq2 |
| ADediting_511300 | chr15_90945736_+ | SINE | Alu | Name=AluSq2 |
| ADediting_511301 | chr15_90945759_+ | SINE | Alu | Name=AluSq2 |
| ADediting_511302 | chr15_90945762_+ | SINE | Alu | Name=AluSq2 |
| ADediting_511303 | chr15_90945771_+ | SINE | Alu | Name=AluSq2 |
| ADediting_511304 | chr15_90945816_+ | SINE | Alu | Name=AluSq2 |
| ADediting_511305 | chr15_90945902_+ | SINE | Alu | Name=AluSq2 |
| ADediting_511306 | chr15_90946043_+ | SINE | Alu | Name=AluSx1 |
| ADediting_511307 | chr15_90947046_+ | SINE | Alu | Name=AluJb |
| ADediting_511308 | chr15_90947104_+ | SINE | Alu | Name=AluJb |
| ADediting_511309 | chr15_90951029_+ | SINE | Alu | Name=AluSg |
| ADediting_511310 | chr15_90951051_+ | SINE | Alu | Name=AluSg |
| ADediting_511311 | chr15_90951056_+ | SINE | Alu | Name=AluSg |
| ADediting_511312 | chr15_90951108_+ | SINE | Alu | Name=AluSg |
| ADediting_511313 | chr15_90951204_+ | SINE | Alu | Name=AluSg |
| ADediting_511314 | chr15_90951267_+ | SINE | Alu | Name=AluSg |
| ADediting_511315 | chr15_90951279_+ | SINE | Alu | Name=AluSg |
| ADediting_511316 | chr15_90951534_+ | SINE | Alu | Name=FLAM_C |
| ADediting_511317 | chr15_90951791_+ | SINE | Alu | Name=AluJb |
| ADediting_511318 | chr15_90951797_+ | SINE | Alu | Name=AluJb |
| ADediting_511319 | chr15_90951807_+ | SINE | Alu | Name=AluJb |
| ADediting_511320 | chr15_90951820_+ | SINE | Alu | Name=AluJb |
| ADediting_511321 | chr15_90951824_+ | SINE | Alu | Name=AluJb |
| ADediting_511322 | chr15_90951833_+ | SINE | Alu | Name=AluJb |
| ADediting_511323 | chr15_90951838_+ | SINE | Alu | Name=AluJb |
| ADediting_511324 | chr15_90951863_+ | SINE | Alu | Name=AluJb |
| ADediting_511325 | chr15_90951897_+ | SINE | Alu | Name=AluJb |
| ADediting_1540826 | chr15_90937626_+ | SINE | Alu | Name=AluSc8 |
| ADediting_1540827 | chr15_90938025_+ | SINE | Alu | Name=AluJb |
| ADediting_1540828 | chr15_90938049_+ | SINE | Alu | Name=AluJb |
| ADediting_1540829 | chr15_90951027_+ | SINE | Alu | Name=AluSg |
| ADediting_1540830 | chr15_90951107_+ | SINE | Alu | Name=AluSg |
| ADediting_1540831 | chr15_90951125_+ | SINE | Alu | Name=AluSg |
| ADediting_1540832 | chr15_90951499_+ | SINE | Alu | Name=FLAM_C |
| ADediting_1540833 | chr15_90951517_+ | SINE | Alu | Name=FLAM_C |
| ADediting_1540834 | chr15_90951892_+ | SINE | Alu | Name=AluJb |
| ADediting_1623616 | chr15_90949016_+ | SINE | Alu | Name=AluY |
Top |
RNA A-to-I editing events in the alternative splicing sites for UNC45A |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
Top |
Differntial gene expression between RNA A-to-I edited versus non-edited samples for UNC45A |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for UNC45A |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for UNC45A |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_107020 | chr1_37500952_- | ENSG00000140553.18 | ENST00000394275.7 | UNC45A-201 | hsa-miR-5581-3p | chr15 | 90953763 | 90953769 | 7mer-m8 | 90953748 | 90953770 | 150 | -19.81 |
| ADediting_107020 | chr1_37500952_- | ENSG00000140553.18 | ENST00000418476.2 | UNC45A-202 | hsa-miR-5581-3p | chr15 | 90953763 | 90953769 | 7mer-m8 | 90953748 | 90953770 | 150 | -19.81 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000140553.18 | ENST00000394275.7 | UNC45A-201 | hsa-miR-641 | chr15 | 90953849 | 90953855 | 7mer-m8 | 90953830 | 90953856 | 146 | -16.31 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000140553.18 | ENST00000418476.2 | UNC45A-202 | hsa-miR-641 | chr15 | 90953849 | 90953855 | 7mer-m8 | 90953830 | 90953856 | 146 | -16.31 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1337757 | chr7_5495852_- | ENSG00000140553.18 | ENST00000394275.7 | UNC45A-201 | hsa-miR-589-3p | chr15 | 90953857 | 90953864 | 8mer-1a | 90953843 | 90953864 | 151 | -16 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000140553.18 | ENST00000418476.2 | UNC45A-202 | hsa-miR-589-3p | chr15 | 90953857 | 90953864 | 8mer-1a | 90953843 | 90953864 | 151 | -16 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for UNC45A |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for UNC45A |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| CER | ADediting_1540829 | chr15_90951027_+ | 0.000721390789865037 | 0.273100557164332 | 5.39795585167315e-08 | 0.426190392061202 | 0.00280307426576116 | 0.242391892279378 |
| CER | ADediting_1540831 | chr15_90951125_+ | 0.000457872638570437 | 0.282629966508877 | 2.66071865037115e-06 | 0.37259881107026 | 0.0858107443936311 | 0.140746091098507 |
| CER | ADediting_1540834 | chr15_90951892_+ | 0.00381211453405248 | 0.234887931530797 | 1.0299918272989e-08 | 0.446411412477952 | 0.0976066784742131 | 0.135767006050769 |
| DLPFC | ADediting_511262 | chr15_90943758_+ | 5.87697923341496e-05 | 0.226140459668323 | 0.0565768810015982 | 0.108404256186851 | 1.22157906740469e-12 | 0.38899039892764 |
| DLPFC | ADediting_511266 | chr15_90943792_+ | 0.000637625580890895 | 0.192917842618533 | 0.0363463225297106 | 0.118934430784014 | 3.68143256136023e-10 | 0.346267237058941 |
| DLPFC | ADediting_511267 | chr15_90943793_+ | 0.00170631540036756 | 0.177475400431142 | 0.146825414087533 | 0.082594781758302 | 7.51841158989968e-12 | 0.376059210053001 |
| DLPFC | ADediting_511268 | chr15_90943794_+ | 0.002368271947114 | 0.172048295719255 | 0.16332061215619 | 0.0793689953648801 | 2.7904810497534e-11 | 0.366358320036194 |
| DLPFC | ADediting_511269 | chr15_90943828_+ | 0.000312612989151413 | 0.203405904766203 | 0.14511567737719 | 0.08294460527835 | 7.76847772788959e-13 | 0.392125036250769 |
| DLPFC | ADediting_511270 | chr15_90943834_+ | 0.000297702659972009 | 0.204105970063404 | 0.207472299468941 | 0.071791835340421 | 2.14283201163598e-13 | 0.400866883159123 |
| DLPFC | ADediting_511272 | chr15_90943863_+ | 0.000746417168523378 | 0.190525565271841 | 0.140451501214502 | 0.0839151848348122 | 1.65241182982841e-08 | 0.313746872545172 |
| DLPFC | ADediting_511273 | chr15_90943872_+ | 2.12028976544843e-07 | 0.289519767340743 | 0.000287047140200898 | 0.204626579252693 | 7.91804932338851e-11 | 0.358404647394344 |
| DLPFC | ADediting_511274 | chr15_90943878_+ | 1.92699932476601e-06 | 0.266571131991256 | 0.00196799878697588 | 0.175132274941948 | 9.82154999791665e-10 | 0.338235807075825 |
| DLPFC | ADediting_511275 | chr15_90943881_+ | 1.33963301405942e-05 | 0.244488892064974 | 0.000961881007007706 | 0.186613534452842 | 2.77889089581697e-09 | 0.329463952060892 |
| DLPFC | ADediting_511276 | chr15_90943886_+ | 1.52955715514961e-06 | 0.269073265214067 | 0.00868662737284484 | 0.148811952150626 | 3.61960383278898e-15 | 0.426989486385872 |
| DLPFC | ADediting_511278 | chr15_90943898_+ | 1.22733491698664e-10 | 0.354995332967668 | 1.00864631892363e-09 | 0.338014739244765 | 3.41095889724424e-06 | 0.260274417174197 |
| DLPFC | ADediting_511283 | chr15_90944132_+ | 1.82562677684751e-08 | 0.312840657807967 | 3.29118725281165e-08 | 0.307420137452407 | 3.86466419993633e-05 | 0.231492878627636 |
| DLPFC | ADediting_511287 | chr15_90944223_+ | 0.00206720576027813 | 0.174317928014387 | 0.135730508615806 | 0.0849230440124894 | 6.15658563605062e-19 | 0.476024328744395 |
| DLPFC | ADediting_511292 | chr15_90944312_+ | 0.00258029969206638 | 0.170602813511695 | 0.0155036515500289 | 0.137371825082211 | 4.87036671241127e-09 | 0.324613622425921 |
| DLPFC | ADediting_511302 | chr15_90945762_+ | 0.558722212910812 | -0.0333364679684847 | 0.0127894244256952 | -0.141259561385833 | 2.5849595656409e-17 | 0.455869002463835 |
| DLPFC | ADediting_511303 | chr15_90945771_+ | 0.495615890696267 | -0.0388434564698665 | 0.0116411646259074 | -0.14312737284876 | 4.67544730540932e-18 | 0.465256213986409 |
| DLPFC | ADediting_511305 | chr15_90945902_+ | 0.58948896854403 | -0.030762919306122 | 0.0230789514701644 | -0.1290293911859 | 2.46215606503393e-12 | 0.384070061209833 |
| CER | ADediting_511309 | chr15_90951029_+ | 0.00314986761575906 | 0.239571736981008 | 2.38944989330339e-06 | 0.374211471692959 | 0.433790578892297 | 0.0643811945431683 |
| DLPFC | ADediting_511310 | chr15_90951051_+ | 0.0176793308948198 | 0.134665423562267 | 0.595559633558636 | 0.0302625769986226 | 2.45341459473583e-15 | 0.429364446607208 |
| CER | ADediting_511310 | chr15_90951051_+ | 0.000283724086057392 | 0.292311189040333 | 9.59096147785841e-12 | 0.519548974186411 | 0.00099529907437351 | 0.266140575988902 |
| DLPFC | ADediting_511311 | chr15_90951056_+ | 0.0113562608813009 | 0.143615922749216 | 0.413407776150657 | 0.0466173080165675 | 7.65152533637736e-14 | 0.407676547791249 |
| CER | ADediting_511311 | chr15_90951056_+ | 0.000596002860533018 | 0.277144531318231 | 2.88008325236447e-10 | 0.486042780549459 | 0.00680564583461745 | 0.220086002248368 |
| CER | ADediting_511312 | chr15_90951108_+ | 0.00436963259499519 | 0.231482188632962 | 6.5930720621784e-07 | 0.392880634490662 | 0.0165068210871957 | 0.195498721788596 |
| CER | ADediting_511315 | chr15_90951279_+ | 0.0268531585518916 | 0.180763958735382 | 3.70168761484709e-05 | 0.330103658953618 | 0.0684003145841101 | 0.14920923135045 |
| CER | ADediting_511316 | chr15_90951534_+ | 0.00239155898044193 | 0.246180249399851 | 1.03056119789179e-06 | 0.386534044667971 | 0.0492728643214532 | 0.160840119853598 |
| CER | ADediting_511317 | chr15_90951791_+ | 0.00445782463400329 | 0.230979613490906 | 2.75361788061975e-06 | 0.372082298241751 | 0.000207023458528368 | 0.298504280765672 |
| CER | ADediting_511318 | chr15_90951797_+ | 1.20248868548403e-05 | 0.349007712305581 | 5.90814135860958e-07 | 0.394419104755334 | 1.08442853291649e-05 | 0.350685292480707 |
| CER | ADediting_511319 | chr15_90951807_+ | 0.000270370532946822 | 0.293267586728995 | 2.60719322679118e-11 | 0.510072103368788 | 8.93937151849618e-05 | 0.314361421582218 |
| CER | ADediting_511320 | chr15_90951820_+ | 0.000271504453368364 | 0.293184690762498 | 2.47967704189995e-09 | 0.46279974501033 | 0.0115082157036233 | 0.205826370489966 |
| CER | ADediting_511321 | chr15_90951824_+ | 0.000684092817848438 | 0.27423112103992 | 3.81745726628195e-11 | 0.506380334781589 | 0.00400544131760704 | 0.23365904313879 |
| CER | ADediting_511322 | chr15_90951833_+ | 0.000272665817442647 | 0.293100120782649 | 2.41724392644902e-11 | 0.510799265080056 | 0.00212873980866191 | 0.248922223513456 |
| CER | ADediting_511324 | chr15_90951863_+ | 0.00245255372389151 | 0.245583134721469 | 3.74872739704052e-09 | 0.458131761815063 | 0.0678367383179442 | 0.149511142681078 |
| CER | ADediting_511325 | chr15_90951897_+ | 0.00119495844275447 | 0.262103400004026 | 1.48702241865976e-09 | 0.468479945859658 | 0.0177910378724429 | 0.193293099990392 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 2.89654966764556e-33 | 0.612157061158006 | 2.19789163489049e-46 | 0.696910781998452 | 3.48006615947128e-15 | 0.427230426756493 |
| AC | 6.49755750083528e-55 | 0.791325423577941 | 5.85757995764458e-35 | 0.67764358898307 | 5.48509609340252e-26 | 0.60147355917436 |
| PCC | 4.86686165383555e-20 | 0.599713831930338 | 1.65318382819922e-20 | 0.605695365793833 | 5.47569290899026e-05 | 0.287610303637543 |
| CER | 1.86600782132897e-18 | 0.637137577417984 | 8.21584116944947e-34 | 0.794064596475464 | 6.04567430919324e-05 | 0.321452326485104 |
| TCX | 3.23479487593517e-12 | 0.529526943278692 | 3.13928676432469e-09 | 0.460144280329322 | 9.14440601880807e-05 | 0.313944798970075 |
| FP | 1.70896427002689e-33 | 0.750568865362516 | 1.9486682310578e-22 | 0.646390428542461 | 6.42007921813885e-12 | 0.485580151825748 |
| IFG | 3.21192715354352e-08 | 0.861458005888336 | 5.19873856540282e-07 | 0.820195547315323 | 0.0149827035490673 | 0.480774680952051 |
| STG | 5.11050860729796e-19 | 0.788835729739714 | 8.6323642056483e-08 | 0.544443074861476 | 0.00366265682186004 | 0.313708782880933 |
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Relation with AD stages for UNC45A |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| CER | ADediting_511310 | chr15_90951051_+ | 0.00042306672569509 | 0.333341332969171 |
| CER | ADediting_511311 | chr15_90951056_+ | 5.25145063097638e-06 | 0.422471523393575 |
| CER | ADediting_511317 | chr15_90951791_+ | 2.63110858474448e-05 | 0.392658605544981 |
| CER | ADediting_511318 | chr15_90951797_+ | 6.74765006173516e-05 | 0.373810288781435 |
| CER | ADediting_511319 | chr15_90951807_+ | 1.60480833583746e-06 | 0.442722577800215 |
| CER | ADediting_511320 | chr15_90951820_+ | 0.000241347364775589 | 0.346301520783204 |
| CER | ADediting_511321 | chr15_90951824_+ | 0.000102761367738194 | 0.365003476950657 |
| CER | ADediting_511322 | chr15_90951833_+ | 9.17816547651632e-06 | 0.412461517687518 |
| CER | ADediting_511324 | chr15_90951863_+ | 0.000152038842825759 | 0.356566453910686 |
| CER | ADediting_511325 | chr15_90951897_+ | 1.11400239504351e-05 | 0.408912186287377 |
| CER | ADediting_1540831 | chr15_90951125_+ | 0.000335421660269247 | 0.338769902825348 |
| CER | ADediting_1540834 | chr15_90951892_+ | 0.0001476214536969 | 0.357209725264112 |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 3.50001574035706e-08 | 0.500384952674818 |
| TCX | 0.000512332725434264 | 0.331769751286034 |
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RelatedDrugs for UNC45A |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for UNC45A |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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