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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited versus non-edited samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with AD stages

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene


Gene summary for EMC3

check button Gene summary
Gene informationGene symbol

EMC3

Gene ID

55831

Gene nameER membrane protein complex subunit 3
SynonymsPOB|TMEM111
Cytomap

3p25.3

Type of geneprotein-coding
DescriptionER membrane protein complex subunit 330 kDa proteinpartial optokinetic response btransmembrane protein 111
Modification date20200313
UniProtAcc

Q9P0I2,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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RNA A-to-I events for EMC3

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_1100336(9963572, -), ADediting_1100337(9963573, -), ADediting_1100338(9963611, -), ADediting_1100339(9963612, -), ADediting_1100340(9963638, -), ADediting_1100341(9963681, -), ADediting_1100342(9963748, -), ADediting_1100343(9963749, -), ADediting_1100344(9965156, -), ADediting_1100345(9965189, -), ADediting_1100346(9965190, -), ADediting_1100347(9965282, -), ADediting_1100348(9965326, -), ADediting_1100349(9965335, -), ADediting_1100350(9965338, -), ADediting_1100351(9965339, -), ADediting_1100352(9965352, -), ADediting_1100353(9965359, -), ADediting_1100354(9965374, -), ADediting_1100355(9965407, -), ADediting_1100356(9966320, -), ADediting_1100357(9966855, -), ADediting_1100358(9968988, -), ADediting_1100359(9968989, -), ADediting_1100360(9969043, -), ADediting_1100361(9969052, -), ADediting_1100362(9969062, -), ADediting_1100363(9969097, -), ADediting_1100364(9972514, -), ADediting_1100365(9972536, -), ADediting_1100366(9972588, -), ADediting_1100367(9972591, -), ADediting_1100368(9972599, -), ADediting_1100369(9972607, -), ADediting_1100370(9972647, -), ADediting_1100371(9972658, -), ADediting_1100372(9972687, -), ADediting_1100373(9972688, -), ADediting_1100374(9972694, -), ADediting_1100375(9972701, -), ADediting_1100376(9972713, -), ADediting_1100377(9972743, -), ADediting_1100378(9972751, -), ADediting_1100379(9972925, -), ADediting_1100380(9972953, -), ADediting_1100381(9972957, -), ADediting_1100382(9972967, -), ADediting_1100383(9972993, -), ADediting_1100384(9972998, -), ADediting_1100385(9973023, -), ADediting_1100386(9973096, -), ADediting_1100387(9973097, -), ADediting_1100388(9973103, -), ADediting_1100389(9973467, -), ADediting_1100391(9975568, -), ADediting_1100392(9975690, -), ADediting_1100393(9975705, -), ADediting_1100394(9976234, -), ADediting_1100395(9976244, -), ADediting_1100396(9978602, -), ADediting_1100397(9978638, -), ADediting_1100398(9978718, -), ADediting_1100399(9978747, -), ADediting_1100400(9978761, -), ADediting_1100401(9980433, -), ADediting_1100402(9980450, -), ADediting_1100403(9980504, -), ADediting_1100404(9980622, -), ADediting_1100405(9980655, -), ADediting_1100406(9980660, -), ADediting_1100407(9980669, -), ADediting_1100408(9980947, -), ADediting_1100409(9980977, -), ADediting_1100410(9981011, -), ADediting_1100411(9981020, -), ADediting_1100412(9981083, -), ADediting_1100413(9981093, -), ADediting_1100414(9981707, -), ADediting_1100415(9981710, -), ADediting_1100418(9982062, -), ADediting_1100419(9982114, -), ADediting_1100420(9982118, -), ADediting_1100421(9982120, -), ADediting_1100447(9982196, -), ADediting_1100453(9982297, -), ADediting_1100454(9982365, -), ADediting_1100455(9982382, -), ADediting_1100456(9982391, -), ADediting_1100457(9982456, -), ADediting_1100458(9982685, -), ADediting_1100459(9982732, -), ADediting_1100460(9982762, -), ADediting_1100461(9982775, -), ADediting_1100462(9982792, -), ADediting_1100463(9982803, -), ADediting_1100464(9982810, -), ADediting_1100465(9982840, -), ADediting_1100466(9983226, -), ADediting_1100467(9983239, -), ADediting_1100468(9983240, -), ADediting_1100469(9983259, -), ADediting_1100470(9983273, -), ADediting_1100471(9983285, -), ADediting_1100472(9983318, -), ADediting_1100473(9983321, -), ADediting_1100474(9983434, -), ADediting_1100475(9983523, -), ADediting_1100476(9983524, -), ADediting_1100477(9983550, -), ADediting_1100478(9983571, -), ADediting_1100479(9983595, -), ADediting_1100480(9983625, -), ADediting_1100481(9983626, -), ADediting_1100482(9983656, -), ADediting_1100483(9984246, -), ADediting_1100484(9984264, -), ADediting_1100485(9984308, -), ADediting_1100486(9984575, -), ADediting_1100487(9985722, -), ADediting_1100488(9985728, -), ADediting_1100489(9985812, -), ADediting_1100490(9985842, -), ADediting_1575877(9981647, -), ADediting_1575878(9981702, -), ADediting_1575879(9981708, -),

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RNA editing positional annotations for EMC3 using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred
ADediting_1100414chr3_9981707_-nonsynonymous SNVENST00000429759.5c.A196Gp.I66V0.447.-0.03
ADediting_1100415chr3_9981710_-nonsynonymous SNVENST00000429759.5c.A193Gp.I65V0.238.-0.03
ADediting_1575877chr3_9981647_-nonsynonymous SNVENST00000429759.5c.A256Gp.T86A1.0.-0.03
ADediting_1575878chr3_9981702_-synonymous SNVENST00000429759.5c.A201Gp.P67P...
ADediting_1575879chr3_9981708_-nonsynonymous SNVENST00000429759.5c.A195Gp.I65M0.051.-0.03

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_1100336chr3_9963572_-UTR3
ADediting_1100337chr3_9963573_-UTR3
ADediting_1100338chr3_9963611_-UTR3
ADediting_1100339chr3_9963612_-UTR3
ADediting_1100340chr3_9963638_-UTR3
ADediting_1100341chr3_9963681_-UTR3
ADediting_1100342chr3_9963748_-UTR3
ADediting_1100343chr3_9963749_-UTR3
ADediting_1100344chr3_9965156_-intronic
ADediting_1100345chr3_9965189_-intronic
ADediting_1100346chr3_9965190_-intronic
ADediting_1100347chr3_9965282_-intronic
ADediting_1100348chr3_9965326_-intronic
ADediting_1100349chr3_9965335_-intronic
ADediting_1100350chr3_9965338_-intronic
ADediting_1100351chr3_9965339_-intronic
ADediting_1100352chr3_9965352_-intronic
ADediting_1100353chr3_9965359_-intronic
ADediting_1100354chr3_9965374_-intronic
ADediting_1100355chr3_9965407_-intronic
ADediting_1100356chr3_9966320_-intronic
ADediting_1100357chr3_9966855_-intronic
ADediting_1100358chr3_9968988_-intronic
ADediting_1100359chr3_9968989_-intronic
ADediting_1100360chr3_9969043_-intronic
ADediting_1100361chr3_9969052_-intronic
ADediting_1100362chr3_9969062_-intronic
ADediting_1100363chr3_9969097_-intronic
ADediting_1100364chr3_9972514_-intronic
ADediting_1100365chr3_9972536_-intronic
ADediting_1100366chr3_9972588_-intronic
ADediting_1100367chr3_9972591_-intronic
ADediting_1100368chr3_9972599_-intronic
ADediting_1100369chr3_9972607_-intronic
ADediting_1100370chr3_9972647_-intronic
ADediting_1100371chr3_9972658_-intronic
ADediting_1100372chr3_9972687_-intronic
ADediting_1100373chr3_9972688_-intronic
ADediting_1100374chr3_9972694_-intronic
ADediting_1100375chr3_9972701_-intronic
ADediting_1100376chr3_9972713_-intronic
ADediting_1100377chr3_9972743_-intronic
ADediting_1100378chr3_9972751_-intronic
ADediting_1100379chr3_9972925_-intronic
ADediting_1100380chr3_9972953_-intronic
ADediting_1100381chr3_9972957_-intronic
ADediting_1100382chr3_9972967_-intronic
ADediting_1100383chr3_9972993_-intronic
ADediting_1100384chr3_9972998_-intronic
ADediting_1100385chr3_9973023_-intronic
ADediting_1100386chr3_9973096_-intronic
ADediting_1100387chr3_9973097_-intronic
ADediting_1100388chr3_9973103_-intronic
ADediting_1100389chr3_9973467_-intronic
ADediting_1100391chr3_9975568_-intronic
ADediting_1100392chr3_9975690_-intronic
ADediting_1100393chr3_9975705_-intronic
ADediting_1100394chr3_9976234_-intronic
ADediting_1100395chr3_9976244_-intronic
ADediting_1100396chr3_9978602_-intronic
ADediting_1100397chr3_9978638_-intronic
ADediting_1100398chr3_9978718_-intronic
ADediting_1100399chr3_9978747_-intronic
ADediting_1100400chr3_9978761_-intronic
ADediting_1100401chr3_9980433_-intronic
ADediting_1100402chr3_9980450_-intronic
ADediting_1100403chr3_9980504_-intronic
ADediting_1100404chr3_9980622_-intronic
ADediting_1100405chr3_9980655_-intronic
ADediting_1100406chr3_9980660_-intronic
ADediting_1100407chr3_9980669_-intronic
ADediting_1100408chr3_9980947_-intronic
ADediting_1100409chr3_9980977_-intronic
ADediting_1100410chr3_9981011_-intronic
ADediting_1100411chr3_9981020_-intronic
ADediting_1100412chr3_9981083_-intronic
ADediting_1100413chr3_9981093_-intronic
ADediting_1100414chr3_9981707_-exonic
ADediting_1100415chr3_9981710_-exonic
ADediting_1100418chr3_9982062_-intronic
ADediting_1100419chr3_9982114_-intronic
ADediting_1100420chr3_9982118_-intronic
ADediting_1100421chr3_9982120_-intronic
ADediting_1100447chr3_9982196_-intronic
ADediting_1100453chr3_9982297_-intronic
ADediting_1100454chr3_9982365_-intronic
ADediting_1100455chr3_9982382_-intronic
ADediting_1100456chr3_9982391_-intronic
ADediting_1100457chr3_9982456_-intronic
ADediting_1100458chr3_9982685_-intronic
ADediting_1100459chr3_9982732_-intronic
ADediting_1100460chr3_9982762_-intronic
ADediting_1100461chr3_9982775_-intronic
ADediting_1100462chr3_9982792_-intronic
ADediting_1100463chr3_9982803_-intronic
ADediting_1100464chr3_9982810_-intronic
ADediting_1100465chr3_9982840_-intronic
ADediting_1100466chr3_9983226_-intronic
ADediting_1100467chr3_9983239_-intronic
ADediting_1100468chr3_9983240_-intronic
ADediting_1100469chr3_9983259_-intronic
ADediting_1100470chr3_9983273_-intronic
ADediting_1100471chr3_9983285_-intronic
ADediting_1100472chr3_9983318_-intronic
ADediting_1100473chr3_9983321_-intronic
ADediting_1100474chr3_9983434_-intronic
ADediting_1100475chr3_9983523_-intronic
ADediting_1100476chr3_9983524_-intronic
ADediting_1100477chr3_9983550_-intronic
ADediting_1100478chr3_9983571_-intronic
ADediting_1100479chr3_9983595_-intronic
ADediting_1100480chr3_9983625_-intronic
ADediting_1100481chr3_9983626_-intronic
ADediting_1100482chr3_9983656_-intronic
ADediting_1100483chr3_9984246_-intronic
ADediting_1100484chr3_9984264_-intronic
ADediting_1100485chr3_9984308_-intronic
ADediting_1100486chr3_9984575_-intronic
ADediting_1100487chr3_9985722_-intronic
ADediting_1100488chr3_9985728_-intronic
ADediting_1100489chr3_9985812_-intronic
ADediting_1100490chr3_9985842_-intronic
ADediting_1575877chr3_9981647_-exonic
ADediting_1575878chr3_9981702_-exonic
ADediting_1575879chr3_9981708_-exonic

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_1100336chr3_9963572_-SINEAluName=AluSg7
ADediting_1100337chr3_9963573_-SINEAluName=AluSg7
ADediting_1100338chr3_9963611_-SINEAluName=AluSg7
ADediting_1100339chr3_9963612_-SINEAluName=AluSg7
ADediting_1100340chr3_9963638_-SINEAluName=AluSg7
ADediting_1100341chr3_9963681_-SINEAluName=AluSg7
ADediting_1100342chr3_9963748_-SINEAluName=AluSg7
ADediting_1100343chr3_9963749_-SINEAluName=AluSg7
ADediting_1100344chr3_9965156_-SINEAluName=AluJr
ADediting_1100345chr3_9965189_-SINEAluName=AluJr
ADediting_1100346chr3_9965190_-SINEAluName=AluJr
ADediting_1100347chr3_9965282_-SINEAluName=AluJr
ADediting_1100348chr3_9965326_-SINEAluName=AluJr
ADediting_1100349chr3_9965335_-SINEAluName=AluJr
ADediting_1100350chr3_9965338_-SINEAluName=AluJr
ADediting_1100351chr3_9965339_-SINEAluName=AluJr
ADediting_1100352chr3_9965352_-SINEAluName=AluJr
ADediting_1100353chr3_9965359_-SINEAluName=AluJr
ADediting_1100354chr3_9965374_-SINEAluName=AluJr
ADediting_1100355chr3_9965407_-SINEAluName=AluJr
ADediting_1100356chr3_9966320_-SINEAluName=AluSg7
ADediting_1100357chr3_9966855_-SINEAluName=AluSz
ADediting_1100358chr3_9968988_-SINEAluName=AluSq2
ADediting_1100359chr3_9968989_-SINEAluName=AluSq2
ADediting_1100360chr3_9969043_-SINEAluName=AluSq2
ADediting_1100361chr3_9969052_-SINEAluName=AluSq2
ADediting_1100362chr3_9969062_-SINEAluName=AluSq2
ADediting_1100363chr3_9969097_-SINEAluName=AluSq2
ADediting_1100364chr3_9972514_-SINEAluName=AluSz
ADediting_1100365chr3_9972536_-SINEAluName=AluSz
ADediting_1100366chr3_9972588_-SINEAluName=AluSz
ADediting_1100367chr3_9972591_-SINEAluName=AluSz
ADediting_1100368chr3_9972599_-SINEAluName=AluSz
ADediting_1100369chr3_9972607_-SINEAluName=AluSz
ADediting_1100370chr3_9972647_-SINEAluName=AluSz
ADediting_1100371chr3_9972658_-SINEAluName=AluSz
ADediting_1100372chr3_9972687_-SINEAluName=AluSz
ADediting_1100373chr3_9972688_-SINEAluName=AluSz
ADediting_1100374chr3_9972694_-SINEAluName=AluSz
ADediting_1100375chr3_9972701_-SINEAluName=AluSz
ADediting_1100376chr3_9972713_-SINEAluName=AluSz
ADediting_1100377chr3_9972743_-SINEAluName=AluSz
ADediting_1100378chr3_9972751_-SINEAluName=AluSz
ADediting_1100379chr3_9972925_-SINEAluName=AluY
ADediting_1100380chr3_9972953_-SINEAluName=AluY
ADediting_1100381chr3_9972957_-SINEAluName=AluY
ADediting_1100382chr3_9972967_-SINEAluName=AluY
ADediting_1100383chr3_9972993_-SINEAluName=AluY
ADediting_1100384chr3_9972998_-SINEAluName=AluY
ADediting_1100385chr3_9973023_-SINEAluName=AluY
ADediting_1100386chr3_9973096_-SINEAluName=AluY
ADediting_1100387chr3_9973097_-SINEAluName=AluY
ADediting_1100388chr3_9973103_-SINEAluName=AluY
ADediting_1100389chr3_9973467_-SINEAluName=AluY
ADediting_1100391chr3_9975568_-SINEAluName=AluY
ADediting_1100392chr3_9975690_-SINEAluName=AluY
ADediting_1100393chr3_9975705_-SINEAluName=AluY
ADediting_1100394chr3_9976234_-SINEAluName=AluSx1
ADediting_1100395chr3_9976244_-SINEAluName=AluSx1
ADediting_1100396chr3_9978602_-SINEAluName=AluSg
ADediting_1100397chr3_9978638_-SINEAluName=AluSg
ADediting_1100398chr3_9978718_-SINEAluName=AluSg
ADediting_1100399chr3_9978747_-SINEAluName=AluSg
ADediting_1100400chr3_9978761_-SINEAluName=AluSg
ADediting_1100401chr3_9980433_-SINEAluName=AluJb
ADediting_1100402chr3_9980450_-SINEAluName=AluJb
ADediting_1100403chr3_9980504_-SINEAluName=AluJb
ADediting_1100404chr3_9980622_-SINEAluName=AluJb
ADediting_1100405chr3_9980655_-SINEAluName=AluJb
ADediting_1100406chr3_9980660_-SINEAluName=AluJb
ADediting_1100407chr3_9980669_-SINEAluName=AluJb
ADediting_1100408chr3_9980947_-SINEAluName=AluJo
ADediting_1100409chr3_9980977_-SINEAluName=AluJo
ADediting_1100410chr3_9981011_-SINEAluName=AluJo
ADediting_1100411chr3_9981020_-SINEAluName=AluJo
ADediting_1100412chr3_9981083_-SINEAluName=AluJo
ADediting_1100413chr3_9981093_-SINEAluName=AluJo
ADediting_1100414chr3_9981707_-SINEAluName=AluJb
ADediting_1100415chr3_9981710_-SINEAluName=AluJb
ADediting_1100418chr3_9982062_-SINEAluName=AluSx
ADediting_1100419chr3_9982114_-SINEAluName=AluSx
ADediting_1100420chr3_9982118_-SINEAluName=AluSx
ADediting_1100421chr3_9982120_-SINEAluName=AluSx
ADediting_1100447chr3_9982196_-SINEAluName=AluSx
ADediting_1100453chr3_9982297_-SINEAluName=AluSc8
ADediting_1100454chr3_9982365_-SINEAluName=AluSc8
ADediting_1100455chr3_9982382_-SINEAluName=AluSc8
ADediting_1100456chr3_9982391_-SINEAluName=AluSc8
ADediting_1100457chr3_9982456_-SINEAluName=AluSc8
ADediting_1100458chr3_9982685_-SINEAluName=AluJb
ADediting_1100459chr3_9982732_-SINEAluName=AluJb
ADediting_1100460chr3_9982762_-SINEAluName=AluJb
ADediting_1100461chr3_9982775_-SINEAluName=AluJb
ADediting_1100462chr3_9982792_-SINEAluName=AluJb
ADediting_1100463chr3_9982803_-SINEAluName=AluJb
ADediting_1100464chr3_9982810_-SINEAluName=AluJb
ADediting_1100465chr3_9982840_-SINEAluName=AluJb
ADediting_1100466chr3_9983226_-SINEAluName=AluSz
ADediting_1100467chr3_9983239_-SINEAluName=AluSz
ADediting_1100468chr3_9983240_-SINEAluName=AluSz
ADediting_1100469chr3_9983259_-SINEAluName=AluSz
ADediting_1100470chr3_9983273_-SINEAluName=AluSz
ADediting_1100471chr3_9983285_-SINEAluName=AluSz
ADediting_1100472chr3_9983318_-SINEAluName=AluSz
ADediting_1100473chr3_9983321_-SINEAluName=AluSz
ADediting_1100474chr3_9983434_-SINEAluName=AluSz
ADediting_1100475chr3_9983523_-SINEAluName=AluSx
ADediting_1100476chr3_9983524_-SINEAluName=AluSx
ADediting_1100477chr3_9983550_-SINEAluName=AluSx
ADediting_1100478chr3_9983571_-SINEAluName=AluSx
ADediting_1100479chr3_9983595_-SINEAluName=AluSx
ADediting_1100480chr3_9983625_-SINEAluName=AluSx
ADediting_1100481chr3_9983626_-SINEAluName=AluSx
ADediting_1100482chr3_9983656_-SINEAluName=AluSx
ADediting_1100483chr3_9984246_-SINEAluName=AluSc
ADediting_1100484chr3_9984264_-SINEAluName=AluSc
ADediting_1100485chr3_9984308_-SINEAluName=AluSc
ADediting_1100486chr3_9984575_-SINEAluName=AluY
ADediting_1100487chr3_9985722_-SINEAluName=AluSq
ADediting_1100488chr3_9985728_-SINEAluName=AluSq
ADediting_1100489chr3_9985812_-SINEAluName=AluSq
ADediting_1100490chr3_9985842_-SINEAluName=AluSq
ADediting_1575877chr3_9981647_-SINEAluName=AluJb
ADediting_1575878chr3_9981702_-SINEAluName=AluJb
ADediting_1575879chr3_9981708_-SINEAluName=AluJb

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RNA A-to-I editing events in the alternative splicing sites for EMC3

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for EMC3

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
boxplot
boxplot
boxplot
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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ADeditome IDChrPositoingSkipped exonENSGENSTs

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Protein coding region RNA A-to-I editings for EMC3

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.
all structure


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The effects of the RNA editing to the miRNA binding sites for EMC3

check buttonRNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
all structure

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1100337chr3_9963573_-ENSG00000125037.12ENST00000245046.6EMC3-201hsa-miR-498-5pchr3996357199635777mer-m899635709963591141-12.18
ADediting_1100339chr3_9963612_-ENSG00000125037.12ENST00000245046.6EMC3-201hsa-miR-513a-5pchr3996361199636177mer-m899636109963627140-14.96
ADediting_1100339chr3_9963612_-ENSG00000125037.12ENST00000245046.6EMC3-201hsa-miR-638chr3996360699636127mer-1a99636069963630143-29.48
ADediting_1100341chr3_9963681_-ENSG00000125037.12ENST00000245046.6EMC3-201hsa-miR-3190-5pchr3996368199636877mer-m899636809963699148-19.57
ADediting_1100341chr3_9963681_-ENSG00000125037.12ENST00000245046.6EMC3-201hsa-miR-4793-5pchr3996367799636837mer-m899636769963695148-19.01
ADediting_1100342chr3_9963748_-ENSG00000125037.12ENST00000245046.6EMC3-201hsa-miR-8052chr3996374399637497mer-1a99637439963761140-24.15
ADediting_1100343chr3_9963749_-ENSG00000125037.12ENST00000245046.6EMC3-201hsa-miR-513a-5pchr3996374899637547mer-m899637479963764144-16.68
ADediting_1100343chr3_9963749_-ENSG00000125037.12ENST00000245046.6EMC3-201hsa-miR-638chr3996374399637497mer-1a99637439963767157-32.92

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1100336chr3_9963572_-ENSG00000125037.12ENST00000245046.6EMC3-201hsa-miR-4503chr3996357199635788mer-1a99635719963592145-11.67
ADediting_1100337chr3_9963573_-ENSG00000125037.12ENST00000245046.6EMC3-201hsa-miR-4503chr3996357199635788mer-1a99635719963592145-11.67
ADediting_1100337chr3_9963573_-ENSG00000125037.12ENST00000245046.6EMC3-201hsa-miR-6792-5pchr3996357299635798mer-1a99635729963591150-19.95
ADediting_1100338chr3_9963611_-ENSG00000125037.12ENST00000245046.6EMC3-201hsa-miR-10399-5pchr3996361099636167mer-m899636099963628145-11.45
ADediting_1100338chr3_9963611_-ENSG00000125037.12ENST00000245046.6EMC3-201hsa-miR-5089-5pchr3996360699636127mer-m899636059963623146-13.74
ADediting_1100338chr3_9963611_-ENSG00000125037.12ENST00000245046.6EMC3-201hsa-miR-6504-3pchr3996361099636167mer-m899636099963633144-13.75
ADediting_1100339chr3_9963612_-ENSG00000125037.12ENST00000245046.6EMC3-201hsa-miR-10399-5pchr3996361099636167mer-m899636099963628145-11.45
ADediting_1100339chr3_9963612_-ENSG00000125037.12ENST00000245046.6EMC3-201hsa-miR-6504-3pchr3996361099636167mer-m899636099963633144-13.75
ADediting_1100340chr3_9963638_-ENSG00000125037.12ENST00000245046.6EMC3-201hsa-miR-4735-5pchr3996363799636437mer-m899636369963657140-4.28
ADediting_1100342chr3_9963748_-ENSG00000125037.12ENST00000245046.6EMC3-201hsa-miR-10399-5pchr3996374799637537mer-m899637469963767144-10.39
ADediting_1100342chr3_9963748_-ENSG00000125037.12ENST00000245046.6EMC3-201hsa-miR-5089-5pchr3996374399637497mer-m899637429963764148-14.13
ADediting_1100342chr3_9963748_-ENSG00000125037.12ENST00000245046.6EMC3-201hsa-miR-6504-3pchr3996374799637537mer-m899637469963767152-15.11
ADediting_1100343chr3_9963749_-ENSG00000125037.12ENST00000245046.6EMC3-201hsa-miR-10399-5pchr3996374799637537mer-m899637469963767144-10.39
ADediting_1100343chr3_9963749_-ENSG00000125037.12ENST00000245046.6EMC3-201hsa-miR-6504-3pchr3996374799637537mer-m899637469963767152-15.11
ADediting_1100343chr3_9963749_-ENSG00000125037.12ENST00000245046.6EMC3-201hsa-miR-7151-3pchr3996374899637558mer-1a99637489963772145-17.48

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1337758chr7_5495892_-ENSG00000125037.12ENST00000245046.6EMC3-201hsa-miR-589-5pchr3996392099639267mer-m899639199963940147-20.09
ADediting_843620chr2_207754818_+ENSG00000125037.12ENST00000245046.6EMC3-201hsa-miR-4775chr3996308999630957mer-m899630889963106143-9.53

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1643790chr3_121049689_+ENSG00000125037.12ENST00000245046.6EMC3-201hsa-miR-5682chr3996295699629627mer-m899629559962977142-13.99

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for EMC3

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.
ENST00000245046.6protein_codingSoverviewSoverview
ENST00000429759.5protein_codingSoverviewSoverview

check button RNA A-to-I editing in miRNA.
ADeditom_IDENSTmir_IDEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in mRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI
ADediting_1100336ENST00000245046.6chr3_9963572_-1742-998.10-996.90-1005.90
ADediting_1100337ENST00000245046.6chr3_9963573_-1741-997.50-996.90-1005.90
ADediting_1100338ENST00000245046.6chr3_9963611_-1703-1003.10-996.90-1005.90
ADediting_1100339ENST00000245046.6chr3_9963612_-1702-996.60-996.90-1005.90
ADediting_1100340ENST00000245046.6chr3_9963638_-1676-996.60-996.90-1005.90
ADediting_1100341ENST00000245046.6chr3_9963681_-1633-996.60-996.90-1005.90
ADediting_1100342ENST00000245046.6chr3_9963748_-1566-996.90-996.90-1005.90
ADediting_1100343ENST00000245046.6chr3_9963749_-1565-997.30-996.90-1005.90
ADediting_1575877ENST00000429759.5chr3_9981647_-277-207.20-207.20-210.70
ADediting_1575878ENST00000429759.5chr3_9981702_-222-206.80-207.20-210.70
ADediting_1100414ENST00000429759.5chr3_9981707_-217-209.00-207.20-210.70
ADediting_1575879ENST00000429759.5chr3_9981708_-216-208.80-207.20-210.70
ADediting_1100415ENST00000429759.5chr3_9981710_-214-207.20-207.20-210.70

check button RNA A-to-I editing in lncRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for EMC3

check button Correlation between ADAR gene expression and RNA editing frequency
TissueADeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFCADediting_1100344chr3_9965156_-0.08390151479373490.0983304784620750.9882704862638250.0008383640884197021.71014381602461e-110.370018202159245
DLPFCADediting_1100350chr3_9965338_-0.4913384862504890.03922951240396220.475115250715989-0.04071039740689341.08452947568497e-090.337411355133665
DLPFCADediting_1100374chr3_9972694_-0.003379518925965720.165979836070560.982888604857851-0.00122308219525194.01424055301711e-250.542528158524363
DLPFCADediting_1100402chr3_9980450_-0.784147933965122-0.0156196254798420.252460966653966-0.06519131176437022.83018100794441e-090.32930719909044

check button Correlation between ADAR gene expression and this gene's expression
TissueADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFC2.5485474152295e-450.6909872847673893.46452018308945e-270.5618086873428180.2428472013105420.0665274942212787
AC9.86395413646625e-740.8580613962684234.47301448886155e-430.7311554062177752.3297598064012e-170.501928317116162
PCC3.00297514698781e-300.7069912110144136.05776480016357e-290.6955339228956790.01150146549789760.182512808913501
CER2.71606766774195e-330.7902809583251962.27137442614719e-250.7212234910208870.0001628734276528730.3031261076209
TCX1.02111712383016e-490.8800349100262476.25255599287786e-130.5440214059570350.001438431083641910.257943355007006
FP2.6625237052041e-100.4509798738560371.32976553714524e-160.568130842539280.176301346504051-0.101807730641671
IFG1.32300935193096e-060.8034876978671570.000919514945672910.6211971825409950.949415863234379-0.013372149449172
PG7.11228245998267e-280.6923166837041161.41452408409047e-220.6371705091082110.0571052307023899-0.139755147173409
STG4.41544634001717e-130.6888088307487738.41737213494784e-110.6354315746641270.118427912438719-0.171668280901956

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Relation with AD stages for EMC3

check button Correlation between AD stages and RNA editing frequency
TissueADeditomIDpositionP-valCoeff.

check button Correlation between AD stages and this gene's expression
TissueP-valCoeff.
CER0.0002450751939839280.345954963399818
TCX6.4414359992954e-050.378100942193383

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RelatedDrugs for EMC3

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for EMC3

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource