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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited versus non-edited samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

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Relation with AD stages

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Related drugs with this gene

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Related diseases with this gene


Gene summary for ADAP2

check button Gene summary
Gene informationGene symbol

ADAP2

Gene ID

55803

Gene nameArfGAP with dual PH domains 2
SynonymsCENTA2|HSA272195|cent-b
Cytomap

17q11.2

Type of geneprotein-coding
Descriptionarf-GAP with dual PH domain-containing protein 2centaurin betacentaurin-alpha 2 protein
Modification date20200313
UniProtAcc

Q9NPF8,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
ADAP2

GO:0048017

inositol lipid-mediated signaling

14690521


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RNA A-to-I events for ADAP2

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_607739(30907163, +), ADediting_607740(30907180, +), ADediting_607741(30907197, +), ADediting_607742(30907202, +), ADediting_607743(30907204, +), ADediting_607744(30907252, +), ADediting_607745(30907283, +), ADediting_607746(30907704, +), ADediting_607747(30907731, +), ADediting_607748(30907736, +), ADediting_607749(30907744, +), ADediting_607750(30907763, +), ADediting_607751(30907766, +), ADediting_607752(30907771, +), ADediting_607753(30907814, +), ADediting_607754(30908196, +), ADediting_607755(30908287, +), ADediting_607756(30908301, +), ADediting_607757(30908340, +), ADediting_607758(30910087, +), ADediting_607759(30910092, +), ADediting_607760(30910195, +), ADediting_607761(30910222, +), ADediting_607762(30910273, +), ADediting_607763(30911655, +), ADediting_607764(30912018, +), ADediting_607765(30912024, +), ADediting_607766(30912382, +), ADediting_607767(30912406, +), ADediting_607768(30913535, +), ADediting_607769(30913581, +), ADediting_607770(30914734, +), ADediting_607771(30915265, +), ADediting_607772(30915330, +), ADediting_607773(30937405, +), ADediting_607774(30937411, +), ADediting_607775(30939547, +), ADediting_607776(30939664, +), ADediting_607777(30939677, +), ADediting_607778(30939691, +), ADediting_607779(30939692, +), ADediting_607780(30940061, +), ADediting_607781(30944643, +), ADediting_607782(30946259, +), ADediting_607783(30946269, +), ADediting_607784(30946319, +), ADediting_607785(30946466, +), ADediting_607786(30946480, +), ADediting_607787(30946481, +), ADediting_607788(30947377, +), ADediting_607789(30958636, +), ADediting_607790(30958638, +), ADediting_607791(30958639, +), ADediting_607792(30958644, +), ADediting_607793(30958656, +), ADediting_607794(30958665, +), ADediting_607795(30958680, +), ADediting_607796(30958692, +), ADediting_607797(30958694, +), ADediting_607798(30958703, +), ADediting_607799(30958704, +), ADediting_607800(30958706, +), ADediting_607801(30958708, +), ADediting_607802(30958719, +), ADediting_607803(30958725, +), ADediting_607804(30958728, +), ADediting_607805(30958729, +), ADediting_607806(30958737, +), ADediting_607807(30958738, +), ADediting_607808(30958739, +), ADediting_607809(30958742, +), ADediting_607810(30958750, +), ADediting_607811(30958755, +), ADediting_607812(30958756, +), ADediting_607813(30958759, +), ADediting_607814(30958760, +), ADediting_607815(30958768, +), ADediting_607816(30958796, +), ADediting_607817(30958804, +), ADediting_607818(30958828, +), ADediting_607819(30958830, +), ADediting_607820(30958846, +),

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RNA editing positional annotations for ADAP2 using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_607739chr17_30907163_+upstream
ADediting_607740chr17_30907180_+upstream
ADediting_607741chr17_30907197_+upstream
ADediting_607742chr17_30907202_+upstream
ADediting_607743chr17_30907204_+upstream
ADediting_607744chr17_30907252_+intergenic
ADediting_607745chr17_30907283_+intergenic
ADediting_607746chr17_30907704_+intergenic
ADediting_607747chr17_30907731_+intergenic
ADediting_607748chr17_30907736_+intergenic
ADediting_607749chr17_30907744_+intergenic
ADediting_607750chr17_30907763_+intergenic
ADediting_607751chr17_30907766_+intergenic
ADediting_607752chr17_30907771_+intergenic
ADediting_607753chr17_30907814_+intergenic
ADediting_607754chr17_30908196_+intergenic
ADediting_607755chr17_30908287_+intergenic
ADediting_607756chr17_30908301_+intergenic
ADediting_607757chr17_30908340_+intergenic
ADediting_607758chr17_30910087_+intergenic
ADediting_607759chr17_30910092_+intergenic
ADediting_607760chr17_30910195_+intergenic
ADediting_607761chr17_30910222_+intergenic
ADediting_607762chr17_30910273_+intergenic
ADediting_607763chr17_30911655_+intergenic
ADediting_607764chr17_30912018_+intergenic
ADediting_607765chr17_30912024_+intergenic
ADediting_607766chr17_30912382_+intergenic
ADediting_607767chr17_30912406_+intergenic
ADediting_607768chr17_30913535_+intergenic
ADediting_607769chr17_30913581_+intergenic
ADediting_607770chr17_30914734_+intergenic
ADediting_607771chr17_30915265_+intergenic
ADediting_607772chr17_30915330_+intergenic
ADediting_607773chr17_30937405_+intronic
ADediting_607774chr17_30937411_+intronic
ADediting_607775chr17_30939547_+intronic
ADediting_607776chr17_30939664_+intronic
ADediting_607777chr17_30939677_+intronic
ADediting_607778chr17_30939691_+intronic
ADediting_607779chr17_30939692_+intronic
ADediting_607780chr17_30940061_+intronic
ADediting_607781chr17_30944643_+intronic
ADediting_607782chr17_30946259_+intronic
ADediting_607783chr17_30946269_+intronic
ADediting_607784chr17_30946319_+intronic
ADediting_607785chr17_30946466_+intronic
ADediting_607786chr17_30946480_+intronic
ADediting_607787chr17_30946481_+intronic
ADediting_607788chr17_30947377_+intronic
ADediting_607789chr17_30958636_+UTR3
ADediting_607790chr17_30958638_+UTR3
ADediting_607791chr17_30958639_+UTR3
ADediting_607792chr17_30958644_+UTR3
ADediting_607793chr17_30958656_+UTR3
ADediting_607794chr17_30958665_+UTR3
ADediting_607795chr17_30958680_+UTR3
ADediting_607796chr17_30958692_+UTR3
ADediting_607797chr17_30958694_+UTR3
ADediting_607798chr17_30958703_+UTR3
ADediting_607799chr17_30958704_+UTR3
ADediting_607800chr17_30958706_+UTR3
ADediting_607801chr17_30958708_+UTR3
ADediting_607802chr17_30958719_+UTR3
ADediting_607803chr17_30958725_+UTR3
ADediting_607804chr17_30958728_+UTR3
ADediting_607805chr17_30958729_+UTR3
ADediting_607806chr17_30958737_+UTR3
ADediting_607807chr17_30958738_+UTR3
ADediting_607808chr17_30958739_+UTR3
ADediting_607809chr17_30958742_+UTR3
ADediting_607810chr17_30958750_+UTR3
ADediting_607811chr17_30958755_+UTR3
ADediting_607812chr17_30958756_+UTR3
ADediting_607813chr17_30958759_+UTR3
ADediting_607814chr17_30958760_+UTR3
ADediting_607815chr17_30958768_+UTR3
ADediting_607816chr17_30958796_+UTR3
ADediting_607817chr17_30958804_+UTR3
ADediting_607818chr17_30958828_+UTR3
ADediting_607819chr17_30958830_+UTR3
ADediting_607820chr17_30958846_+UTR3

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_607739chr17_30907163_+SINEAluName=AluSx
ADediting_607740chr17_30907180_+SINEAluName=AluSx
ADediting_607741chr17_30907197_+SINEAluName=AluSx
ADediting_607742chr17_30907202_+SINEAluName=AluSx
ADediting_607743chr17_30907204_+SINEAluName=AluSx
ADediting_607744chr17_30907252_+SINEAluName=AluSx
ADediting_607745chr17_30907283_+SINEAluName=AluSx
ADediting_607746chr17_30907704_+SINEAluName=AluJb
ADediting_607747chr17_30907731_+SINEAluName=AluJb
ADediting_607748chr17_30907736_+SINEAluName=AluJb
ADediting_607749chr17_30907744_+SINEAluName=AluJb
ADediting_607750chr17_30907763_+SINEAluName=AluJb
ADediting_607751chr17_30907766_+SINEAluName=AluJb
ADediting_607752chr17_30907771_+SINEAluName=AluJb
ADediting_607753chr17_30907814_+SINEAluName=AluJb
ADediting_607754chr17_30908196_+SINEAluName=AluY
ADediting_607755chr17_30908287_+SINEAluName=AluY
ADediting_607756chr17_30908301_+SINEAluName=AluY
ADediting_607757chr17_30908340_+SINEAluName=AluY
ADediting_607758chr17_30910087_+SINEAluName=AluSq2
ADediting_607759chr17_30910092_+SINEAluName=AluSq2
ADediting_607760chr17_30910195_+SINEAluName=AluSq2
ADediting_607761chr17_30910222_+SINEAluName=AluSq2
ADediting_607762chr17_30910273_+SINEAluName=AluSq2
ADediting_607763chr17_30911655_+SINEAluName=AluY
ADediting_607764chr17_30912018_+SINEAluName=AluY
ADediting_607765chr17_30912024_+SINEAluName=AluY
ADediting_607766chr17_30912382_+SINEAluName=AluSz6
ADediting_607767chr17_30912406_+SINEAluName=AluSz6
ADediting_607768chr17_30913535_+SINEAluName=AluSx
ADediting_607769chr17_30913581_+SINEAluName=AluSx
ADediting_607770chr17_30914734_+SINEAluName=AluSz
ADediting_607771chr17_30915265_+SINEAluName=AluSz6
ADediting_607772chr17_30915330_+SINEAluName=AluSz6
ADediting_607773chr17_30937405_+SINEAluName=AluSx
ADediting_607774chr17_30937411_+SINEAluName=AluSx
ADediting_607775chr17_30939547_+SINEAluName=AluYk3
ADediting_607776chr17_30939664_+SINEAluName=AluYk3
ADediting_607777chr17_30939677_+SINEAluName=AluYk3
ADediting_607778chr17_30939691_+SINEAluName=AluYk3
ADediting_607779chr17_30939692_+SINEAluName=AluYk3
ADediting_607780chr17_30940061_+SINEAluName=AluJb
ADediting_607781chr17_30944643_+SINEAluName=AluSx1
ADediting_607782chr17_30946259_+SINEAluName=AluSz
ADediting_607783chr17_30946269_+SINEAluName=AluSz
ADediting_607784chr17_30946319_+SINEAluName=AluSz
ADediting_607785chr17_30946466_+SINEAluName=AluSz
ADediting_607786chr17_30946480_+SINEAluName=AluSz
ADediting_607787chr17_30946481_+SINEAluName=AluSz
ADediting_607788chr17_30947377_+SINEAluName=AluSx
ADediting_607789chr17_30958636_+SINEAluName=AluJb
ADediting_607790chr17_30958638_+SINEAluName=AluJb
ADediting_607791chr17_30958639_+SINEAluName=AluJb
ADediting_607792chr17_30958644_+SINEAluName=AluJb
ADediting_607793chr17_30958656_+SINEAluName=AluJb
ADediting_607794chr17_30958665_+SINEAluName=AluJb
ADediting_607795chr17_30958680_+SINEAluName=AluJb
ADediting_607796chr17_30958692_+SINEAluName=AluJb
ADediting_607797chr17_30958694_+SINEAluName=AluJb
ADediting_607798chr17_30958703_+SINEAluName=AluJb
ADediting_607799chr17_30958704_+SINEAluName=AluJb
ADediting_607800chr17_30958706_+SINEAluName=AluJb
ADediting_607801chr17_30958708_+SINEAluName=AluJb
ADediting_607802chr17_30958719_+SINEAluName=AluJb
ADediting_607803chr17_30958725_+SINEAluName=AluJb
ADediting_607804chr17_30958728_+SINEAluName=AluJb
ADediting_607805chr17_30958729_+SINEAluName=AluJb
ADediting_607806chr17_30958737_+SINEAluName=AluJb
ADediting_607807chr17_30958738_+SINEAluName=AluJb
ADediting_607808chr17_30958739_+SINEAluName=AluJb
ADediting_607809chr17_30958742_+SINEAluName=AluJb
ADediting_607810chr17_30958750_+SINEAluName=AluJb
ADediting_607811chr17_30958755_+SINEAluName=AluJb
ADediting_607812chr17_30958756_+SINEAluName=AluJb
ADediting_607813chr17_30958759_+SINEAluName=AluJb
ADediting_607814chr17_30958760_+SINEAluName=AluJb
ADediting_607815chr17_30958768_+SINEAluName=AluJb
ADediting_607816chr17_30958796_+SINEAluName=AluJb
ADediting_607817chr17_30958804_+SINEAluName=AluJb
ADediting_607818chr17_30958828_+SINEAluName=AluJb
ADediting_607819chr17_30958830_+SINEAluName=AluJb
ADediting_607820chr17_30958846_+SINEAluName=AluJb

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RNA A-to-I editing events in the alternative splicing sites for ADAP2

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for ADAP2

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
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check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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ADeditome IDChrPositoingSkipped exonENSGENSTs