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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for OSGEP |
 Gene summary |
| Gene information | Gene symbol | OSGEP | Gene ID | 55644 |
| Gene name | O-sialoglycoprotein endopeptidase | |
| Synonyms | GAMOS3|GCPL1|KAE1|OSGEP1|PRSMG1|TCS3 | |
| Cytomap | 14q11.2 | |
| Type of gene | protein-coding | |
| Description | probable tRNA N6-adenosine threonylcarbamoyltransferaseN6-L-threonylcarbamoyladenine synthasehOSGEPprobable O-sialoglycoprotein endopeptidaseprobable tRNA threonylcarbamoyladenosine biosynthesis protein OSGEPt(6)A synthaset(6)A37 threonylcarbamoylad | |
| Modification date | 20200313 | |
| UniProtAcc | Q9NPF4, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| OSGEP | GO:0002949 | tRNA threonylcarbamoyladenosine modification | 28805828 |
Top |
RNA A-to-I events for OSGEP |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
 |
| RNA editing frequencies across three data sets. |
 |
| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
 |
| RNA A-to-I editing events in AD. |
| ADediting_418863(20446942, -), ADediting_418864(20446943, -), ADediting_418865(20449703, -), ADediting_418866(20449713, -), ADediting_418867(20449719, -), ADediting_418868(20449733, -), ADediting_418869(20449814, -), ADediting_418870(20449822, -), ADediting_418871(20449826, -), ADediting_418872(20449843, -), ADediting_418873(20449854, -), ADediting_418874(20449859, -), ADediting_418875(20449869, -), ADediting_418876(20449873, -), ADediting_418877(20449883, -), ADediting_418878(20449894, -), ADediting_418879(20449899, -), ADediting_418880(20449900, -), ADediting_418881(20449902, -), ADediting_418882(20449906, -), ADediting_418883(20450073, -), ADediting_418884(20450074, -), ADediting_418885(20450076, -), ADediting_418886(20450079, -), ADediting_418887(20450106, -), ADediting_418888(20450116, -), ADediting_418889(20450120, -), ADediting_418890(20450129, -), ADediting_418891(20450140, -), ADediting_418892(20450149, -), ADediting_418893(20450152, -), ADediting_418894(20450181, -), ADediting_418895(20450182, -), ADediting_418896(20450843, -), ADediting_418897(20450854, -), ADediting_418898(20450856, -), ADediting_418899(20450868, -), ADediting_418900(20450869, -), ADediting_418901(20450887, -), ADediting_418902(20450896, -), ADediting_418903(20450901, -), ADediting_418904(20450908, -), ADediting_418905(20450933, -), ADediting_418906(20450947, -), ADediting_418907(20450950, -), ADediting_418908(20450965, -), ADediting_418909(20450966, -), ADediting_418910(20450979, -), ADediting_418911(20450992, -), ADediting_418912(20451002, -), ADediting_418913(20451005, -), ADediting_418914(20451025, -), ADediting_418915(20451046, -), ADediting_418916(20451047, -), ADediting_418917(20451062, -), ADediting_418918(20451063, -), ADediting_418919(20451067, -), ADediting_418920(20451070, -), ADediting_418921(20451071, -), ADediting_418922(20451076, -), ADediting_418923(20451083, -), ADediting_418924(20451090, -), ADediting_418925(20451113, -), ADediting_418926(20451117, -), ADediting_418927(20451125, -), ADediting_418928(20452052, -), ADediting_418929(20452573, -), ADediting_418930(20452826, -), ADediting_418931(20452835, -), ADediting_418932(20452839, -), ADediting_418933(20452843, -), ADediting_418934(20452937, -), ADediting_418935(20452954, -), ADediting_418936(20452981, -), ADediting_418937(20453439, -), ADediting_418938(20453464, -), ADediting_418939(20453472, -), ADediting_418940(20453478, -), ADediting_418941(20453499, -), ADediting_418942(20453503, -), ADediting_418943(20453504, -), ADediting_418944(20453505, -), ADediting_418945(20453530, -), ADediting_418946(20453531, -), ADediting_418947(20453534, -), ADediting_418948(20453535, -), ADediting_418949(20453538, -), ADediting_418950(20453541, -), ADediting_418951(20453543, -), ADediting_418952(20453544, -), ADediting_418953(20453545, -), ADediting_418954(20453546, -), ADediting_418955(20453547, -), ADediting_418956(20453548, -), ADediting_418957(20453600, -), ADediting_418958(20453605, -), ADediting_418959(20453610, -), ADediting_418960(20453614, -), ADediting_418961(20453618, -), ADediting_418962(20453619, -), ADediting_418963(20453759, -), ADediting_418964(20453765, -), ADediting_418965(20453777, -), ADediting_418966(20453778, -), ADediting_418967(20453787, -), ADediting_418968(20453792, -), ADediting_418969(20453803, -), ADediting_418970(20453805, -), ADediting_418971(20453829, -), ADediting_418972(20453853, -), ADediting_418973(20453856, -), ADediting_418974(20453871, -), ADediting_418975(20453897, -), ADediting_418976(20453903, -), ADediting_418977(20453907, -), ADediting_418978(20453910, -), ADediting_418979(20453924, -), ADediting_418980(20453936, -), ADediting_418981(20453937, -), ADediting_418982(20453943, -), ADediting_418983(20453972, -), ADediting_418984(20453975, -), ADediting_418985(20453985, -), ADediting_1618115(20453870, -), |
Top |
RNA editing positional annotations for OSGEP using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| ADediting_418928 | chr14_20452052_- | nonsynonymous SNV | ENST00000206542.9 | c.A333G | p.I111M | 0.001 | 0.941 | -2.34 |
| ADediting_418928 | chr14_20452052_- | nonsynonymous SNV | ENST00000553640.3 | c.A333G | p.I111M | 0.001 | 0.941 | -2.34 |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_418863 | chr14_20446942_- | UTR3 |
| ADediting_418864 | chr14_20446943_- | UTR3 |
| ADediting_418865 | chr14_20449703_- | intronic |
| ADediting_418866 | chr14_20449713_- | intronic |
| ADediting_418867 | chr14_20449719_- | intronic |
| ADediting_418868 | chr14_20449733_- | intronic |
| ADediting_418869 | chr14_20449814_- | intronic |
| ADediting_418870 | chr14_20449822_- | intronic |
| ADediting_418871 | chr14_20449826_- | intronic |
| ADediting_418872 | chr14_20449843_- | intronic |
| ADediting_418873 | chr14_20449854_- | intronic |
| ADediting_418874 | chr14_20449859_- | intronic |
| ADediting_418875 | chr14_20449869_- | intronic |
| ADediting_418876 | chr14_20449873_- | intronic |
| ADediting_418877 | chr14_20449883_- | intronic |
| ADediting_418878 | chr14_20449894_- | intronic |
| ADediting_418879 | chr14_20449899_- | intronic |
| ADediting_418880 | chr14_20449900_- | intronic |
| ADediting_418881 | chr14_20449902_- | intronic |
| ADediting_418882 | chr14_20449906_- | intronic |
| ADediting_418883 | chr14_20450073_- | intronic |
| ADediting_418884 | chr14_20450074_- | intronic |
| ADediting_418885 | chr14_20450076_- | intronic |
| ADediting_418886 | chr14_20450079_- | intronic |
| ADediting_418887 | chr14_20450106_- | intronic |
| ADediting_418888 | chr14_20450116_- | intronic |
| ADediting_418889 | chr14_20450120_- | intronic |
| ADediting_418890 | chr14_20450129_- | intronic |
| ADediting_418891 | chr14_20450140_- | intronic |
| ADediting_418892 | chr14_20450149_- | intronic |
| ADediting_418893 | chr14_20450152_- | intronic |
| ADediting_418894 | chr14_20450181_- | intronic |
| ADediting_418895 | chr14_20450182_- | intronic |
| ADediting_418896 | chr14_20450843_- | intronic |
| ADediting_418897 | chr14_20450854_- | intronic |
| ADediting_418898 | chr14_20450856_- | intronic |
| ADediting_418899 | chr14_20450868_- | intronic |
| ADediting_418900 | chr14_20450869_- | intronic |
| ADediting_418901 | chr14_20450887_- | intronic |
| ADediting_418902 | chr14_20450896_- | intronic |
| ADediting_418903 | chr14_20450901_- | intronic |
| ADediting_418904 | chr14_20450908_- | intronic |
| ADediting_418905 | chr14_20450933_- | intronic |
| ADediting_418906 | chr14_20450947_- | intronic |
| ADediting_418907 | chr14_20450950_- | intronic |
| ADediting_418908 | chr14_20450965_- | intronic |
| ADediting_418909 | chr14_20450966_- | intronic |
| ADediting_418910 | chr14_20450979_- | intronic |
| ADediting_418911 | chr14_20450992_- | intronic |
| ADediting_418912 | chr14_20451002_- | intronic |
| ADediting_418913 | chr14_20451005_- | intronic |
| ADediting_418914 | chr14_20451025_- | intronic |
| ADediting_418915 | chr14_20451046_- | intronic |
| ADediting_418916 | chr14_20451047_- | intronic |
| ADediting_418917 | chr14_20451062_- | intronic |
| ADediting_418918 | chr14_20451063_- | intronic |
| ADediting_418919 | chr14_20451067_- | intronic |
| ADediting_418920 | chr14_20451070_- | intronic |
| ADediting_418921 | chr14_20451071_- | intronic |
| ADediting_418922 | chr14_20451076_- | intronic |
| ADediting_418923 | chr14_20451083_- | intronic |
| ADediting_418924 | chr14_20451090_- | intronic |
| ADediting_418925 | chr14_20451113_- | intronic |
| ADediting_418926 | chr14_20451117_- | intronic |
| ADediting_418927 | chr14_20451125_- | intronic |
| ADediting_418928 | chr14_20452052_- | exonic |
| ADediting_418929 | chr14_20452573_- | intronic |
| ADediting_418930 | chr14_20452826_- | intronic |
| ADediting_418931 | chr14_20452835_- | intronic |
| ADediting_418932 | chr14_20452839_- | intronic |
| ADediting_418933 | chr14_20452843_- | intronic |
| ADediting_418934 | chr14_20452937_- | intronic |
| ADediting_418935 | chr14_20452954_- | intronic |
| ADediting_418936 | chr14_20452981_- | intronic |
| ADediting_418937 | chr14_20453439_- | intronic |
| ADediting_418938 | chr14_20453464_- | intronic |
| ADediting_418939 | chr14_20453472_- | intronic |
| ADediting_418940 | chr14_20453478_- | intronic |
| ADediting_418941 | chr14_20453499_- | intronic |
| ADediting_418942 | chr14_20453503_- | intronic |
| ADediting_418943 | chr14_20453504_- | intronic |
| ADediting_418944 | chr14_20453505_- | intronic |
| ADediting_418945 | chr14_20453530_- | intronic |
| ADediting_418946 | chr14_20453531_- | intronic |
| ADediting_418947 | chr14_20453534_- | intronic |
| ADediting_418948 | chr14_20453535_- | intronic |
| ADediting_418949 | chr14_20453538_- | intronic |
| ADediting_418950 | chr14_20453541_- | intronic |
| ADediting_418951 | chr14_20453543_- | intronic |
| ADediting_418952 | chr14_20453544_- | intronic |
| ADediting_418953 | chr14_20453545_- | intronic |
| ADediting_418954 | chr14_20453546_- | intronic |
| ADediting_418955 | chr14_20453547_- | intronic |
| ADediting_418956 | chr14_20453548_- | intronic |
| ADediting_418957 | chr14_20453600_- | intronic |
| ADediting_418958 | chr14_20453605_- | intronic |
| ADediting_418959 | chr14_20453610_- | intronic |
| ADediting_418960 | chr14_20453614_- | intronic |
| ADediting_418961 | chr14_20453618_- | intronic |
| ADediting_418962 | chr14_20453619_- | intronic |
| ADediting_418963 | chr14_20453759_- | intronic |
| ADediting_418964 | chr14_20453765_- | intronic |
| ADediting_418965 | chr14_20453777_- | intronic |
| ADediting_418966 | chr14_20453778_- | intronic |
| ADediting_418967 | chr14_20453787_- | intronic |
| ADediting_418968 | chr14_20453792_- | intronic |
| ADediting_418969 | chr14_20453803_- | intronic |
| ADediting_418970 | chr14_20453805_- | intronic |
| ADediting_418971 | chr14_20453829_- | intronic |
| ADediting_418972 | chr14_20453853_- | intronic |
| ADediting_418973 | chr14_20453856_- | intronic |
| ADediting_418974 | chr14_20453871_- | intronic |
| ADediting_418975 | chr14_20453897_- | intronic |
| ADediting_418976 | chr14_20453903_- | intronic |
| ADediting_418977 | chr14_20453907_- | intronic |
| ADediting_418978 | chr14_20453910_- | intronic |
| ADediting_418979 | chr14_20453924_- | intronic |
| ADediting_418980 | chr14_20453936_- | intronic |
| ADediting_418981 | chr14_20453937_- | intronic |
| ADediting_418982 | chr14_20453943_- | intronic |
| ADediting_418983 | chr14_20453972_- | intronic |
| ADediting_418984 | chr14_20453975_- | intronic |
| ADediting_418985 | chr14_20453985_- | intronic |
| ADediting_1618115 | chr14_20453870_- | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_418863 | chr14_20446942_- | SINE | Alu | Name=FLAM_C |
| ADediting_418864 | chr14_20446943_- | SINE | Alu | Name=FLAM_C |
| ADediting_418865 | chr14_20449703_- | SINE | Alu | Name=AluJr |
| ADediting_418866 | chr14_20449713_- | SINE | Alu | Name=AluJr |
| ADediting_418867 | chr14_20449719_- | SINE | Alu | Name=AluJr |
| ADediting_418868 | chr14_20449733_- | SINE | Alu | Name=AluJr |
| ADediting_418869 | chr14_20449814_- | SINE | Alu | Name=AluJr |
| ADediting_418870 | chr14_20449822_- | SINE | Alu | Name=AluJr |
| ADediting_418871 | chr14_20449826_- | SINE | Alu | Name=AluJr |
| ADediting_418872 | chr14_20449843_- | SINE | Alu | Name=AluJr |
| ADediting_418873 | chr14_20449854_- | SINE | Alu | Name=AluJr |
| ADediting_418874 | chr14_20449859_- | SINE | Alu | Name=AluJr |
| ADediting_418875 | chr14_20449869_- | SINE | Alu | Name=AluJr |
| ADediting_418876 | chr14_20449873_- | SINE | Alu | Name=AluJr |
| ADediting_418877 | chr14_20449883_- | SINE | Alu | Name=AluJr |
| ADediting_418878 | chr14_20449894_- | SINE | Alu | Name=AluJr |
| ADediting_418879 | chr14_20449899_- | SINE | Alu | Name=AluJr |
| ADediting_418880 | chr14_20449900_- | SINE | Alu | Name=AluJr |
| ADediting_418881 | chr14_20449902_- | SINE | Alu | Name=AluJr |
| ADediting_418882 | chr14_20449906_- | SINE | Alu | Name=AluJr |
| ADediting_418883 | chr14_20450073_- | SINE | Alu | Name=AluSx1 |
| ADediting_418884 | chr14_20450074_- | SINE | Alu | Name=AluSx1 |
| ADediting_418885 | chr14_20450076_- | SINE | Alu | Name=AluSx1 |
| ADediting_418886 | chr14_20450079_- | SINE | Alu | Name=AluSx1 |
| ADediting_418887 | chr14_20450106_- | SINE | Alu | Name=AluSx1 |
| ADediting_418888 | chr14_20450116_- | SINE | Alu | Name=AluSx1 |
| ADediting_418889 | chr14_20450120_- | SINE | Alu | Name=AluSx1 |
| ADediting_418890 | chr14_20450129_- | SINE | Alu | Name=AluSx1 |
| ADediting_418891 | chr14_20450140_- | SINE | Alu | Name=AluSx1 |
| ADediting_418892 | chr14_20450149_- | SINE | Alu | Name=AluSx1 |
| ADediting_418893 | chr14_20450152_- | SINE | Alu | Name=AluSx1 |
| ADediting_418894 | chr14_20450181_- | SINE | Alu | Name=AluSx1 |
| ADediting_418895 | chr14_20450182_- | SINE | Alu | Name=AluSx1 |
| ADediting_418896 | chr14_20450843_- | SINE | Alu | Name=AluSq2 |
| ADediting_418897 | chr14_20450854_- | SINE | Alu | Name=AluSq2 |
| ADediting_418898 | chr14_20450856_- | SINE | Alu | Name=AluSq2 |
| ADediting_418899 | chr14_20450868_- | SINE | Alu | Name=AluSq2 |
| ADediting_418900 | chr14_20450869_- | SINE | Alu | Name=AluSq2 |
| ADediting_418901 | chr14_20450887_- | SINE | Alu | Name=AluSq2 |
| ADediting_418902 | chr14_20450896_- | SINE | Alu | Name=AluSq2 |
| ADediting_418903 | chr14_20450901_- | SINE | Alu | Name=AluSq2 |
| ADediting_418904 | chr14_20450908_- | SINE | Alu | Name=AluSq2 |
| ADediting_418905 | chr14_20450933_- | SINE | Alu | Name=AluSq2 |
| ADediting_418906 | chr14_20450947_- | SINE | Alu | Name=AluSq2 |
| ADediting_418907 | chr14_20450950_- | SINE | Alu | Name=AluSq2 |
| ADediting_418908 | chr14_20450965_- | SINE | Alu | Name=AluSq2 |
| ADediting_418909 | chr14_20450966_- | SINE | Alu | Name=AluSq2 |
| ADediting_418910 | chr14_20450979_- | SINE | Alu | Name=AluSq2 |
| ADediting_418911 | chr14_20450992_- | SINE | Alu | Name=AluSq2 |
| ADediting_418912 | chr14_20451002_- | SINE | Alu | Name=AluSq2 |
| ADediting_418913 | chr14_20451005_- | SINE | Alu | Name=AluSq2 |
| ADediting_418914 | chr14_20451025_- | SINE | Alu | Name=AluSq2 |
| ADediting_418915 | chr14_20451046_- | SINE | Alu | Name=AluSq2 |
| ADediting_418916 | chr14_20451047_- | SINE | Alu | Name=AluSq2 |
| ADediting_418917 | chr14_20451062_- | SINE | Alu | Name=AluSq2 |
| ADediting_418918 | chr14_20451063_- | SINE | Alu | Name=AluSq2 |
| ADediting_418919 | chr14_20451067_- | SINE | Alu | Name=AluSq2 |
| ADediting_418920 | chr14_20451070_- | SINE | Alu | Name=AluSq2 |
| ADediting_418921 | chr14_20451071_- | SINE | Alu | Name=AluSq2 |
| ADediting_418922 | chr14_20451076_- | SINE | Alu | Name=AluSq2 |
| ADediting_418923 | chr14_20451083_- | SINE | Alu | Name=AluSq2 |
| ADediting_418924 | chr14_20451090_- | SINE | Alu | Name=AluSq2 |
| ADediting_418925 | chr14_20451113_- | SINE | Alu | Name=AluSq2 |
| ADediting_418926 | chr14_20451117_- | SINE | Alu | Name=AluSq2 |
| ADediting_418927 | chr14_20451125_- | SINE | Alu | Name=AluSq2 |
| ADediting_418930 | chr14_20452826_- | SINE | Alu | Name=AluSx4 |
| ADediting_418931 | chr14_20452835_- | SINE | Alu | Name=AluSx4 |
| ADediting_418932 | chr14_20452839_- | SINE | Alu | Name=AluSx4 |
| ADediting_418933 | chr14_20452843_- | SINE | Alu | Name=AluSx4 |
| ADediting_418934 | chr14_20452937_- | SINE | Alu | Name=AluSx4 |
| ADediting_418935 | chr14_20452954_- | SINE | Alu | Name=AluSx4 |
| ADediting_418936 | chr14_20452981_- | SINE | Alu | Name=AluSx4 |
| ADediting_418937 | chr14_20453439_- | SINE | Alu | Name=AluSp |
| ADediting_418938 | chr14_20453464_- | SINE | Alu | Name=AluSp |
| ADediting_418939 | chr14_20453472_- | SINE | Alu | Name=AluSp |
| ADediting_418940 | chr14_20453478_- | SINE | Alu | Name=AluSp |
| ADediting_418941 | chr14_20453499_- | SINE | Alu | Name=AluSp |
| ADediting_418942 | chr14_20453503_- | SINE | Alu | Name=AluSp |
| ADediting_418943 | chr14_20453504_- | SINE | Alu | Name=AluSp |
| ADediting_418944 | chr14_20453505_- | SINE | Alu | Name=AluSp |
| ADediting_418945 | chr14_20453530_- | SINE | Alu | Name=AluSp |
| ADediting_418946 | chr14_20453531_- | SINE | Alu | Name=AluSp |
| ADediting_418947 | chr14_20453534_- | SINE | Alu | Name=AluSp |
| ADediting_418948 | chr14_20453535_- | SINE | Alu | Name=AluSp |
| ADediting_418949 | chr14_20453538_- | SINE | Alu | Name=AluSp |
| ADediting_418950 | chr14_20453541_- | SINE | Alu | Name=AluSp |
| ADediting_418951 | chr14_20453543_- | SINE | Alu | Name=AluSp |
| ADediting_418952 | chr14_20453544_- | SINE | Alu | Name=AluSp |
| ADediting_418953 | chr14_20453545_- | SINE | Alu | Name=AluSp |
| ADediting_418954 | chr14_20453546_- | SINE | Alu | Name=AluSp |
| ADediting_418955 | chr14_20453547_- | SINE | Alu | Name=AluSp |
| ADediting_418956 | chr14_20453548_- | SINE | Alu | Name=AluSp |
| ADediting_418957 | chr14_20453600_- | SINE | Alu | Name=AluSp |
| ADediting_418958 | chr14_20453605_- | SINE | Alu | Name=AluSp |
| ADediting_418959 | chr14_20453610_- | SINE | Alu | Name=AluSp |
| ADediting_418960 | chr14_20453614_- | SINE | Alu | Name=AluSp |
| ADediting_418961 | chr14_20453618_- | SINE | Alu | Name=AluSp |
| ADediting_418962 | chr14_20453619_- | SINE | Alu | Name=AluSp |
| ADediting_418963 | chr14_20453759_- | SINE | Alu | Name=AluSx |
| ADediting_418964 | chr14_20453765_- | SINE | Alu | Name=AluSx |
| ADediting_418965 | chr14_20453777_- | SINE | Alu | Name=AluSx |
| ADediting_418966 | chr14_20453778_- | SINE | Alu | Name=AluSx |
| ADediting_418967 | chr14_20453787_- | SINE | Alu | Name=AluSx |
| ADediting_418968 | chr14_20453792_- | SINE | Alu | Name=AluSx |
| ADediting_418969 | chr14_20453803_- | SINE | Alu | Name=AluSx |
| ADediting_418970 | chr14_20453805_- | SINE | Alu | Name=AluSx |
| ADediting_418971 | chr14_20453829_- | SINE | Alu | Name=AluSx |
| ADediting_418972 | chr14_20453853_- | SINE | Alu | Name=AluSx |
| ADediting_418973 | chr14_20453856_- | SINE | Alu | Name=AluSx |
| ADediting_418974 | chr14_20453871_- | SINE | Alu | Name=AluSx |
| ADediting_418975 | chr14_20453897_- | SINE | Alu | Name=AluSx |
| ADediting_418976 | chr14_20453903_- | SINE | Alu | Name=AluSx |
| ADediting_418977 | chr14_20453907_- | SINE | Alu | Name=AluSx |
| ADediting_418978 | chr14_20453910_- | SINE | Alu | Name=AluSx |
| ADediting_418979 | chr14_20453924_- | SINE | Alu | Name=AluSx |
| ADediting_418980 | chr14_20453936_- | SINE | Alu | Name=AluSx |
| ADediting_418981 | chr14_20453937_- | SINE | Alu | Name=AluSx |
| ADediting_418982 | chr14_20453943_- | SINE | Alu | Name=AluSx |
| ADediting_418983 | chr14_20453972_- | SINE | Alu | Name=AluSx |
| ADediting_418984 | chr14_20453975_- | SINE | Alu | Name=AluSx |
| ADediting_418985 | chr14_20453985_- | SINE | Alu | Name=AluSx |
| ADediting_1618115 | chr14_20453870_- | SINE | Alu | Name=AluSx |
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RNA A-to-I editing events in the alternative splicing sites for OSGEP |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for OSGEP |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for OSGEP |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for OSGEP |
| RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. |
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| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_418864 | chr14_20446943_- | ENSG00000092094.11 | ENST00000206542.9 | OSGEP-201 | hsa-miR-3613-3p | chr14 | 20446942 | 20446949 | 8mer-1a | 20446942 | 20446965 | 161 | -10.77 |
| ADediting_418864 | chr14_20446943_- | ENSG00000092094.11 | ENST00000206542.9 | OSGEP-201 | hsa-miR-371b-5p | chr14 | 20446940 | 20446947 | 8mer-1a | 20446940 | 20446961 | 146 | -7.79 |
| ADediting_418864 | chr14_20446943_- | ENSG00000092094.11 | ENST00000206542.9 | OSGEP-201 | hsa-miR-373-5p | chr14 | 20446940 | 20446947 | 8mer-1a | 20446940 | 20446961 | 142 | -8.35 |
| ADediting_418864 | chr14_20446943_- | ENSG00000092094.11 | ENST00000206542.9 | OSGEP-201 | hsa-miR-514b-5p | chr14 | 20446939 | 20446945 | 7mer-1a | 20446939 | 20446960 | 146 | -15.02 |
| ADediting_418864 | chr14_20446943_- | ENSG00000092094.11 | ENST00000206542.9 | OSGEP-201 | hsa-miR-616-5p | chr14 | 20446940 | 20446947 | 8mer-1a | 20446940 | 20446961 | 140 | -5.71 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_418928 | chr14_20452052_- | ENSG00000092094.11 | ENST00000554699.1 | OSGEP-205 | hsa-let-7f-2-3p | chr14 | 20452052 | 20452058 | 7mer-m8 | 20452051 | 20452072 | 145 | -15.71 |
| ADediting_418928 | chr14_20452052_- | ENSG00000092094.11 | ENST00000554699.1 | OSGEP-205 | hsa-miR-1185-1-3p | chr14 | 20452052 | 20452058 | 7mer-m8 | 20452051 | 20452072 | 152 | -15.13 |
| ADediting_418928 | chr14_20452052_- | ENSG00000092094.11 | ENST00000554699.1 | OSGEP-205 | hsa-miR-1284 | chr14 | 20452051 | 20452057 | 7mer-m8 | 20452050 | 20452071 | 145 | -15.99 |
| ADediting_418928 | chr14_20452052_- | ENSG00000092094.11 | ENST00000556252.1 | OSGEP-211 | hsa-let-7f-2-3p | chr14 | 20452052 | 20452058 | 7mer-m8 | 20452051 | 20452072 | 145 | -15.71 |
| ADediting_418928 | chr14_20452052_- | ENSG00000092094.11 | ENST00000556252.1 | OSGEP-211 | hsa-miR-1185-1-3p | chr14 | 20452052 | 20452058 | 7mer-m8 | 20452051 | 20452072 | 152 | -15.13 |
| ADediting_418928 | chr14_20452052_- | ENSG00000092094.11 | ENST00000556252.1 | OSGEP-211 | hsa-miR-1284 | chr14 | 20452051 | 20452057 | 7mer-m8 | 20452050 | 20452071 | 145 | -15.99 |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000092094.11 | ENST00000206542.9 | OSGEP-201 | hsa-miR-4477b | chr14 | 20447205 | 20447211 | 7mer-m8 | 20447204 | 20447230 | 152 | -15.5 |
| ADediting_1471004 | chr9_63819627_+ | ENSG00000092094.11 | ENST00000206542.9 | OSGEP-201 | hsa-miR-4477b | chr14 | 20447205 | 20447211 | 7mer-m8 | 20447204 | 20447230 | 152 | -15.5 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000092094.11 | ENST00000206542.9 | OSGEP-201 | hsa-miR-4775 | chr14 | 20446601 | 20446607 | 7mer-m8 | 20446600 | 20446622 | 153 | -7.05 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for OSGEP |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000206542.9 | protein_coding |  |  |
| ENST00000553640.3 | protein_coding |  |  |
| ENST00000554699.1 | lncRNA |  |  |
| ENST00000556252.1 | lncRNA |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_418863 | ENST00000206542.9 | chr14_20446942_- | 1435 | -745.00 | -745.30 | -752.20 |
| ADediting_418864 | ENST00000206542.9 | chr14_20446943_- | 1434 | -745.40 | -745.30 | -752.20 |
| ADediting_418928 | ENST00000206542.9 | chr14_20452052_- | 462 | -751.10 | -745.30 | -752.20 |
| ADediting_418928 | ENST00000553640.3 | chr14_20452052_- | 462 | -243.20 | -237.40 | -243.20 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_418928 | ENST00000554699.1 | chr14_20452052_- | 443 | -286.30 | -280.50 | -286.30 |
| ADediting_418928 | ENST00000556252.1 | chr14_20452052_- | 756 | -341.90 | -336.10 | -341.90 |
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Relation with ADAR for OSGEP |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | ADediting_418865 | chr14_20449703_- | 2.87977369118202e-06 | 0.262157972433505 | 4.23089444453259e-12 | 0.380212406167741 | 0.00538867957828341 | 0.157701099035891 |
| TCX | ADediting_418865 | chr14_20449703_- | 0.00646898641351921 | 0.221418593978496 | 1.81260602307117e-06 | 0.378315835258415 | 0.0065630846413579 | -0.221040025947769 |
| DLPFC | ADediting_418867 | chr14_20449719_- | 6.25493293236814e-06 | 0.253405111556226 | 1.47350627957723e-12 | 0.387682152889534 | 0.0260473486402378 | 0.126403425331805 |
| TCX | ADediting_418867 | chr14_20449719_- | 1.14748246600935e-06 | 0.384987059875539 | 5.45626720159125e-16 | 0.599233547897153 | 0.0209221790171462 | -0.188444359903386 |
| TCX | ADediting_418875 | chr14_20449869_- | 2.57114717346062e-05 | 0.336366465663121 | 1.26479469508368e-09 | 0.470256560214164 | 0.249496418176434 | -0.0946059402269586 |
| DLPFC | ADediting_418881 | chr14_20449902_- | 3.14185675703694e-05 | 0.234091009241135 | 3.70650581118052e-10 | 0.346212460939387 | 0.000504559439754301 | 0.196421125406428 |
| TCX | ADediting_418881 | chr14_20449902_- | 0.000756946294906969 | 0.272071786193292 | 1.64851104715449e-07 | 0.411774980399883 | 0.219956285185651 | -0.100742835687292 |
| FP | ADediting_418881 | chr14_20449902_- | 4.32500110989891e-05 | 0.30147498358017 | 0.000686077900837277 | 0.25212492341037 | 0.0701990115320003 | 0.136038856223639 |
| STG | ADediting_418881 | chr14_20449902_- | 0.000279860850637049 | 0.386677728564216 | 0.0822691616801881 | 0.190708506861119 | 0.0121434912664023 | 0.27252229293087 |
| STG | ADediting_418882 | chr14_20449906_- | 0.00170765421167372 | 0.337228004422275 | 0.0179125621439476 | 0.257787336756655 | 0.0477241782016259 | 0.216688596355158 |
| TCX | ADediting_418898 | chr14_20450856_- | 0.00765066541362833 | 0.216982976131197 | 3.03640436596552e-05 | 0.333525063550383 | 0.263510586715517 | -0.0918704219770616 |
| DLPFC | ADediting_418900 | chr14_20450869_- | 0.00028417069254469 | 0.204770205182616 | 2.16259224752425e-08 | 0.31129384550175 | 0.0779281569725126 | 0.100274947964105 |
| TCX | ADediting_418900 | chr14_20450869_- | 0.00278765762878321 | 0.242524448192422 | 1.28630444864479e-05 | 0.34790871474248 | 0.228008039804056 | -0.0990153812053459 |
| DLPFC | ADediting_418902 | chr14_20450896_- | 3.49195802319522e-06 | 0.260012132218551 | 2.75204208991908e-12 | 0.383281062165532 | 0.0163219096754145 | 0.136317169093322 |
| TCX | ADediting_418906 | chr14_20450947_- | 0.00529766997798574 | 0.226594593191664 | 0.000145985362238718 | 0.305210131812731 | 0.513890219335367 | 0.0537110888958416 |
| DLPFC | ADediting_418915 | chr14_20451046_- | 0.00612208125264477 | 0.155369133254495 | 5.07390095414798e-09 | 0.32425636208151 | 0.111711121697402 | 0.0905172421263318 |
| STG | ADediting_418915 | chr14_20451046_- | 0.0309266662520442 | 0.235662785412853 | 0.00153466573409629 | 0.340379023488187 | 0.723015855653214 | -0.0392447343397909 |
| DLPFC | ADediting_418916 | chr14_20451047_- | 6.36699744124006e-05 | 0.225103203256752 | 2.76587519617651e-11 | 0.366424934873695 | 0.253400916951474 | 0.0650625823416654 |
| DLPFC | ADediting_418917 | chr14_20451062_- | 7.12498801090951e-05 | 0.223638194799752 | 2.7916418940856e-09 | 0.32942472217798 | 0.375138752389476 | 0.0505438825171078 |
| TCX | ADediting_418917 | chr14_20451062_- | 0.00801189427457108 | 0.215748576941733 | 1.19919000752488e-07 | 0.415953102996288 | 0.0647400839871553 | -0.151207486416623 |
| DLPFC | ADediting_418918 | chr14_20451063_- | 0.000664642395292495 | 0.192290400914286 | 2.81360494038264e-11 | 0.366296236712601 | 0.33503069794175 | 0.0549338103204193 |
| CER | ADediting_418918 | chr14_20451063_- | 8.56756256366113e-05 | 0.315140250977736 | 0.000261573351056614 | 0.293921895323968 | 0.962793376821621 | 0.00384095148108072 |
| TCX | ADediting_418918 | chr14_20451063_- | 4.83401246120427e-06 | 0.363482976297425 | 2.52352094482593e-05 | 0.336684146168846 | 0.774207464236784 | 0.0236176107550018 |
| DLPFC | ADediting_418919 | chr14_20451067_- | 0.000975406716999575 | 0.186395891502265 | 2.82102778128005e-10 | 0.348407154733615 | 0.460409042887871 | 0.042076844738436 |
| TCX | ADediting_418919 | chr14_20451067_- | 6.9717964044219e-06 | 0.357751033118264 | 1.18056941634678e-10 | 0.495183301162172 | 0.315770805044529 | -0.0824600721939634 |
| DLPFC | ADediting_418920 | chr14_20451070_- | 0.00166586209362931 | 0.177866634751394 | 3.74765857353212e-09 | 0.326889315922457 | 0.828347099655125 | 0.0123641370327803 |
| TCX | ADediting_418920 | chr14_20451070_- | 0.000101848381132941 | 0.31195661846728 | 3.5191605349462e-07 | 0.401582901730373 | 0.714219181340153 | -0.0301451200498807 |
| PCC | ADediting_418923 | chr14_20451083_- | 0.585619246924888 | -0.0396939532814849 | 0.81859846911976 | 0.0167035259897798 | 3.70068177976329e-06 | 0.327694736818157 |
| TCX | ADediting_418923 | chr14_20451083_- | 0.001070720526978 | 0.264535075131595 | 1.23999506128284e-07 | 0.415516439071945 | 0.448771265965401 | -0.0623078745281987 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 7.28453671101933e-14 | 0.407997714100052 | 1.43164353019352e-29 | 0.582613957698928 | 4.43832868133824e-07 | 0.282066751300637 |
| AC | 6.27807336735385e-66 | 0.833794987088712 | 2.23417494619829e-46 | 0.749784111833707 | 5.24224156317873e-20 | 0.536148228554507 |
| PCC | 1.05134410601014e-21 | 0.620409391037917 | 3.03531815067091e-20 | 0.602344781614046 | 2.68186258767206e-05 | 0.298814223476488 |
| TCX | 0.00163263471971943 | 0.25506336401742 | 0.00630221430214009 | 0.222101750707428 | 8.86814749507842e-05 | 0.314508239338512 |
| FP | 1.37100647744858e-26 | 0.690925278556575 | 6.97311464396695e-26 | 0.683877769090169 | 0.00076917336402575 | 0.249865905033109 |
| IFG | 0.000133543341061363 | 0.690420096065249 | 0.00382095278910552 | 0.557059243852384 | 0.122684922737626 | 0.316925058451378 |
| PG | 1.67218676305141e-17 | 0.571271639565654 | 3.31770452177412e-20 | 0.608269104313659 | 0.299000931500744 | 0.076556520954957 |
| STG | 6.61914492234042e-21 | 0.812417226683708 | 1.88633026239222e-12 | 0.675103530090916 | 0.00933879177032798 | 0.28206011816715 |
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Relation with AD stages for OSGEP |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| IFG | ADediting_418917 | chr14_20451062_- | 0.0113059937049014 | 0.497952103823781 |
| IFG | ADediting_418918 | chr14_20451063_- | 0.0423795586445896 | 0.40894316526528 |
| IFG | ADediting_418919 | chr14_20451067_- | 0.0141781305132572 | 0.484209503533271 |
| IFG | ADediting_418924 | chr14_20451090_- | 0.0354713369979928 | 0.422303326441651 |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
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RelatedDrugs for OSGEP |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for OSGEP |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| OSGEP | C4540266 | GALLOWAY-MOWAT SYNDROME 3 | 2 | UNIPROT |
| OSGEP | C0025958 | Microcephaly | 1 | GENOMICS_ENGLAND |
| OSGEP | C0795949 | Galloway Mowat syndrome | 1 | CTD_human;ORPHANET |
| OSGEP | C1955869 | Malformations of Cortical Development | 1 | GENOMICS_ENGLAND |
| OSGEP | C3714756 | Intellectual Disability | 1 | GENOMICS_ENGLAND |
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