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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited versus non-edited samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with AD stages

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene


Gene summary for PI4K2A

check button Gene summary
Gene informationGene symbol

PI4K2A

Gene ID

55361

Gene namephosphatidylinositol 4-kinase type 2 alpha
SynonymsPI4KII|PIK42A
Cytomap

10q24.2

Type of geneprotein-coding
Descriptionphosphatidylinositol 4-kinase type 2-alphaphosphatidylinositol 4-kinase type II (PI4KII)phosphatidylinositol 4-kinase type II-alpha
Modification date20200313
UniProtAcc

Q9BTU6,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
PI4K2A

GO:0006661

phosphatidylinositol biosynthetic process

11279162

PI4K2A

GO:0046854

phosphatidylinositol phosphorylation

25168678


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RNA A-to-I events for PI4K2A

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_228435(97644271, +), ADediting_228436(97645354, +), ADediting_228437(97645362, +), ADediting_228438(97646267, +), ADediting_228439(97646315, +), ADediting_228440(97646319, +), ADediting_228441(97646332, +), ADediting_228442(97646340, +), ADediting_228443(97646354, +), ADediting_228444(97646479, +), ADediting_228445(97646482, +), ADediting_228446(97650332, +), ADediting_228447(97655155, +), ADediting_228448(97655223, +), ADediting_228449(97655249, +), ADediting_228450(97655621, +), ADediting_228451(97655630, +), ADediting_228452(97655639, +), ADediting_228453(97655668, +), ADediting_228454(97655675, +), ADediting_228455(97655687, +), ADediting_228456(97655692, +), ADediting_228457(97655700, +), ADediting_228458(97655708, +), ADediting_228459(97655714, +), ADediting_228460(97655740, +), ADediting_228461(97655758, +), ADediting_228462(97655784, +), ADediting_228463(97655810, +), ADediting_228464(97657434, +), ADediting_228465(97657490, +), ADediting_228466(97657491, +), ADediting_228467(97657492, +), ADediting_228468(97657521, +), ADediting_228469(97657547, +), ADediting_228470(97657589, +), ADediting_228471(97657892, +), ADediting_228472(97657935, +), ADediting_228473(97657936, +), ADediting_228474(97657962, +), ADediting_228475(97657975, +), ADediting_228476(97658018, +), ADediting_228477(97658066, +), ADediting_228478(97658084, +), ADediting_228479(97663673, +), ADediting_228480(97663761, +), ADediting_228481(97663765, +), ADediting_228482(97663769, +), ADediting_228483(97663770, +), ADediting_228484(97663893, +), ADediting_228485(97663898, +), ADediting_228486(97663903, +), ADediting_228487(97664918, +), ADediting_228488(97668316, +), ADediting_228489(97668322, +), ADediting_228490(97668331, +), ADediting_228491(97668337, +), ADediting_228492(97668382, +), ADediting_228493(97668413, +), ADediting_228494(97668418, +), ADediting_228495(97668431, +), ADediting_228496(97668457, +), ADediting_228497(97668458, +), ADediting_228498(97668487, +), ADediting_228499(97668553, +), ADediting_228500(97668946, +), ADediting_228501(97669128, +), ADediting_228502(97670860, +), ADediting_228503(97670882, +), ADediting_228504(97670883, +), ADediting_228505(97670918, +), ADediting_228506(97670923, +), ADediting_228507(97672303, +), ADediting_228508(97672315, +), ADediting_228509(97673104, +), ADediting_1608047(97657940, +), ADediting_1608048(97657981, +),

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RNA editing positional annotations for PI4K2A using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred
ADediting_228487chr10_97664918_+nonsynonymous SNVENST00000370631.3c.A1018Gp.I340V0.1880.996-0.69

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_228435chr10_97644271_+intronic
ADediting_228436chr10_97645354_+intronic
ADediting_228437chr10_97645362_+intronic
ADediting_228438chr10_97646267_+intronic
ADediting_228439chr10_97646315_+intronic
ADediting_228440chr10_97646319_+intronic
ADediting_228441chr10_97646332_+intronic
ADediting_228442chr10_97646340_+intronic
ADediting_228443chr10_97646354_+intronic
ADediting_228444chr10_97646479_+intronic
ADediting_228445chr10_97646482_+intronic
ADediting_228446chr10_97650332_+intronic
ADediting_228447chr10_97655155_+intronic
ADediting_228448chr10_97655223_+intronic
ADediting_228449chr10_97655249_+intronic
ADediting_228450chr10_97655621_+intronic
ADediting_228451chr10_97655630_+intronic
ADediting_228452chr10_97655639_+intronic
ADediting_228453chr10_97655668_+intronic
ADediting_228454chr10_97655675_+intronic
ADediting_228455chr10_97655687_+intronic
ADediting_228456chr10_97655692_+intronic
ADediting_228457chr10_97655700_+intronic
ADediting_228458chr10_97655708_+intronic
ADediting_228459chr10_97655714_+intronic
ADediting_228460chr10_97655740_+intronic
ADediting_228461chr10_97655758_+intronic
ADediting_228462chr10_97655784_+intronic
ADediting_228463chr10_97655810_+intronic
ADediting_228464chr10_97657434_+intronic
ADediting_228465chr10_97657490_+intronic
ADediting_228466chr10_97657491_+intronic
ADediting_228467chr10_97657492_+intronic
ADediting_228468chr10_97657521_+intronic
ADediting_228469chr10_97657547_+intronic
ADediting_228470chr10_97657589_+intronic
ADediting_228471chr10_97657892_+intronic
ADediting_228472chr10_97657935_+intronic
ADediting_228473chr10_97657936_+intronic
ADediting_228474chr10_97657962_+intronic
ADediting_228475chr10_97657975_+intronic
ADediting_228476chr10_97658018_+intronic
ADediting_228477chr10_97658066_+intronic
ADediting_228478chr10_97658084_+intronic
ADediting_228479chr10_97663673_+intronic
ADediting_228480chr10_97663761_+intronic
ADediting_228481chr10_97663765_+intronic
ADediting_228482chr10_97663769_+intronic
ADediting_228483chr10_97663770_+intronic
ADediting_228484chr10_97663893_+intronic
ADediting_228485chr10_97663898_+intronic
ADediting_228486chr10_97663903_+intronic
ADediting_228487chr10_97664918_+exonic
ADediting_228488chr10_97668316_+intronic
ADediting_228489chr10_97668322_+intronic
ADediting_228490chr10_97668331_+intronic
ADediting_228491chr10_97668337_+intronic
ADediting_228492chr10_97668382_+intronic
ADediting_228493chr10_97668413_+intronic
ADediting_228494chr10_97668418_+intronic
ADediting_228495chr10_97668431_+intronic
ADediting_228496chr10_97668457_+intronic
ADediting_228497chr10_97668458_+intronic
ADediting_228498chr10_97668487_+intronic
ADediting_228499chr10_97668553_+intronic
ADediting_228500chr10_97668946_+intronic
ADediting_228501chr10_97669128_+intronic
ADediting_228502chr10_97670860_+intronic
ADediting_228503chr10_97670882_+intronic
ADediting_228504chr10_97670883_+intronic
ADediting_228505chr10_97670918_+intronic
ADediting_228506chr10_97670923_+intronic
ADediting_228507chr10_97672303_+intronic
ADediting_228508chr10_97672315_+intronic
ADediting_228509chr10_97673104_+intronic
ADediting_1608047chr10_97657940_+intronic
ADediting_1608048chr10_97657981_+intronic

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_228435chr10_97644271_+SINEAluName=AluSx1
ADediting_228436chr10_97645354_+SINEAluName=AluY
ADediting_228437chr10_97645362_+SINEAluName=AluY
ADediting_228438chr10_97646267_+SINEAluName=AluSx1
ADediting_228439chr10_97646315_+SINEAluName=AluSx1
ADediting_228440chr10_97646319_+SINEAluName=AluSx1
ADediting_228441chr10_97646332_+SINEAluName=AluSx1
ADediting_228442chr10_97646340_+SINEAluName=AluSx1
ADediting_228443chr10_97646354_+SINEAluName=AluSx1
ADediting_228444chr10_97646479_+SINEAluName=AluSx1
ADediting_228445chr10_97646482_+SINEAluName=AluSx1
ADediting_228446chr10_97650332_+SINEAluName=AluSz6
ADediting_228447chr10_97655155_+SINEAluName=AluSx
ADediting_228448chr10_97655223_+SINEAluName=AluSx
ADediting_228449chr10_97655249_+SINEAluName=AluSx
ADediting_228450chr10_97655621_+SINEAluName=AluSz
ADediting_228451chr10_97655630_+SINEAluName=AluSz
ADediting_228452chr10_97655639_+SINEAluName=AluSz
ADediting_228453chr10_97655668_+SINEAluName=AluSz
ADediting_228454chr10_97655675_+SINEAluName=AluSz
ADediting_228455chr10_97655687_+SINEAluName=AluSz
ADediting_228456chr10_97655692_+SINEAluName=AluSz
ADediting_228457chr10_97655700_+SINEAluName=AluSz
ADediting_228458chr10_97655708_+SINEAluName=AluSz
ADediting_228459chr10_97655714_+SINEAluName=AluSz
ADediting_228460chr10_97655740_+SINEAluName=AluSz
ADediting_228461chr10_97655758_+SINEAluName=AluSz
ADediting_228462chr10_97655784_+SINEAluName=AluSz
ADediting_228463chr10_97655810_+SINEAluName=AluSz
ADediting_228464chr10_97657434_+SINEAluName=AluSx1
ADediting_228465chr10_97657490_+SINEAluName=AluSx1
ADediting_228466chr10_97657491_+SINEAluName=AluSx1
ADediting_228467chr10_97657492_+SINEAluName=AluSx1
ADediting_228468chr10_97657521_+SINEAluName=AluSx1
ADediting_228469chr10_97657547_+SINEAluName=AluSx1
ADediting_228470chr10_97657589_+SINEAluName=AluSx1
ADediting_228471chr10_97657892_+SINEAluName=AluSx1
ADediting_228472chr10_97657935_+SINEAluName=AluSx1
ADediting_228473chr10_97657936_+SINEAluName=AluSx1
ADediting_228474chr10_97657962_+SINEAluName=AluSx1
ADediting_228475chr10_97657975_+SINEAluName=AluSx1
ADediting_228476chr10_97658018_+SINEAluName=AluSx1
ADediting_228477chr10_97658066_+SINEAluName=AluSx1
ADediting_228478chr10_97658084_+SINEAluName=AluSx1
ADediting_228479chr10_97663673_+SINEAluName=AluSx1
ADediting_228480chr10_97663761_+SINEAluName=AluSx1
ADediting_228481chr10_97663765_+SINEAluName=AluSx1
ADediting_228482chr10_97663769_+SINEAluName=AluSx1
ADediting_228483chr10_97663770_+SINEAluName=AluSx1
ADediting_228484chr10_97663893_+SINEAluName=AluJr
ADediting_228485chr10_97663898_+SINEAluName=AluJr
ADediting_228486chr10_97663903_+SINEAluName=AluJr
ADediting_228488chr10_97668316_+SINEAluName=AluJb
ADediting_228489chr10_97668322_+SINEAluName=AluJb
ADediting_228490chr10_97668331_+SINEAluName=AluJb
ADediting_228491chr10_97668337_+SINEAluName=AluJb
ADediting_228492chr10_97668382_+SINEAluName=AluJb
ADediting_228493chr10_97668413_+SINEAluName=AluJb
ADediting_228494chr10_97668418_+SINEAluName=AluJb
ADediting_228495chr10_97668431_+SINEAluName=AluJb
ADediting_228496chr10_97668457_+SINEAluName=AluJb
ADediting_228497chr10_97668458_+SINEAluName=AluJb
ADediting_228498chr10_97668487_+SINEAluName=AluJb
ADediting_228499chr10_97668553_+SINEAluName=AluJb
ADediting_228500chr10_97668946_+SINEAluName=AluSx
ADediting_228501chr10_97669128_+SINEAluName=AluSx
ADediting_228502chr10_97670860_+SINEAluName=AluSp
ADediting_228503chr10_97670882_+SINEAluName=AluSp
ADediting_228504chr10_97670883_+SINEAluName=AluSp
ADediting_228505chr10_97670918_+SINEAluName=AluSp
ADediting_228506chr10_97670923_+SINEAluName=AluSp
ADediting_228507chr10_97672303_+SINEAluName=AluSg
ADediting_228508chr10_97672315_+SINEAluName=AluSg
ADediting_228509chr10_97673104_+SINEAluName=AluSz
ADediting_1608047chr10_97657940_+SINEAluName=AluSx1
ADediting_1608048chr10_97657981_+SINEAluName=AluSx1

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RNA A-to-I editing events in the alternative splicing sites for PI4K2A

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for PI4K2A

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

ADeditome IDChrPositoingSkipped exonENSGENSTs

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Protein coding region RNA A-to-I editings for PI4K2A

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.
all structure


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The effects of the RNA editing to the miRNA binding sites for PI4K2A


check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1097295chr3_85385762_+ENSG00000155252.13ENST00000370631.3PI4K2A-201hsa-miR-5688chr1097674691976746977mer-m89767467497674698147-11.1
ADediting_1337757chr7_5495852_-ENSG00000155252.13ENST00000370631.3PI4K2A-201hsa-miR-589-3pchr1097676213976762208mer-1a9767619797676220140-13.2
ADediting_1337758chr7_5495892_-ENSG00000155252.13ENST00000370631.3PI4K2A-201hsa-miR-589-5pchr1097676358976763647mer-m89767634497676365157-18.16
ADediting_1391023chr8_140732605_-ENSG00000155252.13ENST00000370631.3PI4K2A-201hsa-miR-151a-3pchr1097675315976753217mer-m89767530197675322146-19.79
ADediting_1471004chr9_63819627_+ENSG00000155252.13ENST00000370631.3PI4K2A-201hsa-miR-4477bchr1097676169976761757mer-m89767615597676176142-10.59
ADediting_1631458chr19_40282624_-ENSG00000155252.13ENST00000370631.3PI4K2A-201hsa-miR-641chr1097675231976752377mer-m89767521497675238154-17.98

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_291761chr11_93733708_-ENSG00000155252.13ENST00000370631.3PI4K2A-201hsa-miR-1304-3pchr1097673915976739217mer-m89767390397673922149-18.99
ADediting_496066chr15_66496985_-ENSG00000155252.13ENST00000370631.3PI4K2A-201hsa-miR-4512chr1097675908976759147mer-m89767589697675915143-19.38

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for PI4K2A

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.
ENST00000370631.3protein_codingSoverviewSoverview

check button RNA A-to-I editing in miRNA.
ADeditom_IDENSTmir_IDEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in mRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI
ADediting_228487ENST00000370631.3chr10_97664918_+1075-1604.80-1598.60-1604.80

check button RNA A-to-I editing in lncRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for PI4K2A

check button Correlation between ADAR gene expression and RNA editing frequency
TissueADeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFCADediting_228458chr10_97655708_+0.412867191612434-0.04667122508216540.0126383634166647-0.141496627079281.19741854282537e-140.419563634474168
DLPFCADediting_228459chr10_97655714_+0.321443783788361-0.05649639143165760.0139172034525527-0.1395636777922142.75059329713047e-110.366466598379564

check button Correlation between ADAR gene expression and this gene's expression
TissueADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFC2.17637428559112e-860.8466746017859841.9031069638445e-1160.9051405476878650.0002822805942981980.204865320823548
AC3.09031408380353e-990.9141528893203155.17334150941586e-770.867083393549741.61082931884313e-100.390231081529729
PCC8.1239424272857e-590.8660970506945843.67676913901754e-750.9122050410258890.04662342697344430.144163390870053
CER1.82737727522742e-290.7597839812965329.6711164126484e-190.6412082610924580.1554510377915240.116565804253123
TCX4.64002522322855e-360.8095751960144199.05257430781402e-380.8204920362271990.0789639395578344-0.143892669089891
FP1.89484504348579e-380.7850214452323291.14557470070628e-430.8155334874589710.007085836592640810.201182125686934
IFG2.61746515610829e-080.8640597422603366.77488735083281e-070.8156236865412090.6020554110299440.109584746261884
PG6.43765868593064e-210.6172715760098621.33015879731618e-260.6801190131122470.0753605361788711-0.130709806945189
STG1.84929906568818e-310.9008835049344123.16017884339216e-160.7474706659658130.6551874364301110.049435422071594

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Relation with AD stages for PI4K2A

check button Correlation between AD stages and RNA editing frequency
TissueADeditomIDpositionP-valCoeff.

check button Correlation between AD stages and this gene's expression
TissueP-valCoeff.

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RelatedDrugs for PI4K2A

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PI4K2A

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource