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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for WDR41 |
 Gene summary |
| Gene information | Gene symbol | WDR41 | Gene ID | 55255 |
| Gene name | WD repeat domain 41 | |
| Synonyms | MSTP048 | |
| Cytomap | 5q13.3-q14.1 | |
| Type of gene | protein-coding | |
| Description | WD repeat-containing protein 41 | |
| Modification date | 20200313 | |
| UniProtAcc | Q9HAD4, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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RNA A-to-I events for WDR41 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_1213797(77442648, -), ADediting_1213798(77442649, -), ADediting_1213799(77442703, -), ADediting_1213800(77443678, -), ADediting_1213801(77443930, -), ADediting_1213802(77443935, -), ADediting_1213803(77443950, -), ADediting_1213804(77443951, -), ADediting_1213805(77443959, -), ADediting_1213806(77443961, -), ADediting_1213807(77443992, -), ADediting_1213808(77444005, -), ADediting_1213809(77444019, -), ADediting_1213810(77444041, -), ADediting_1213811(77444045, -), ADediting_1213812(77444051, -), ADediting_1213813(77444054, -), ADediting_1213814(77444058, -), ADediting_1213815(77444059, -), ADediting_1213816(77444060, -), ADediting_1213817(77444063, -), ADediting_1213818(77444073, -), ADediting_1213819(77444074, -), ADediting_1213820(77444093, -), ADediting_1213821(77444107, -), ADediting_1213822(77444152, -), ADediting_1213823(77444153, -), ADediting_1213824(77444169, -), ADediting_1213825(77444175, -), ADediting_1213826(77448683, -), ADediting_1213827(77448705, -), ADediting_1213828(77448768, -), ADediting_1213829(77448785, -), ADediting_1213830(77448805, -), ADediting_1213831(77481087, -), ADediting_1213832(77481147, -), ADediting_1213833(77481174, -), ADediting_1213834(77481178, -), ADediting_1213835(77481198, -), ADediting_1213836(77481211, -), ADediting_1213837(77481237, -), ADediting_1213838(77481242, -), ADediting_1213839(77481243, -), ADediting_1213840(77481259, -), ADediting_1213841(77481272, -), ADediting_1213842(77481281, -), ADediting_1581937(77442728, -), ADediting_1657948(77481060, -), ADediting_1657949(77481084, -), ADediting_1657950(77481107, -), ADediting_1657951(77481121, -), ADediting_1657952(77481530, -), ADediting_1657953(77481637, -), |
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RNA editing positional annotations for WDR41 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_1213797 | chr5_77442648_- | intronic |
| ADediting_1213798 | chr5_77442649_- | intronic |
| ADediting_1213799 | chr5_77442703_- | intronic |
| ADediting_1213800 | chr5_77443678_- | intronic |
| ADediting_1213801 | chr5_77443930_- | intronic |
| ADediting_1213802 | chr5_77443935_- | intronic |
| ADediting_1213803 | chr5_77443950_- | intronic |
| ADediting_1213804 | chr5_77443951_- | intronic |
| ADediting_1213805 | chr5_77443959_- | intronic |
| ADediting_1213806 | chr5_77443961_- | intronic |
| ADediting_1213807 | chr5_77443992_- | intronic |
| ADediting_1213808 | chr5_77444005_- | intronic |
| ADediting_1213809 | chr5_77444019_- | intronic |
| ADediting_1213810 | chr5_77444041_- | intronic |
| ADediting_1213811 | chr5_77444045_- | intronic |
| ADediting_1213812 | chr5_77444051_- | intronic |
| ADediting_1213813 | chr5_77444054_- | intronic |
| ADediting_1213814 | chr5_77444058_- | intronic |
| ADediting_1213815 | chr5_77444059_- | intronic |
| ADediting_1213816 | chr5_77444060_- | intronic |
| ADediting_1213817 | chr5_77444063_- | intronic |
| ADediting_1213818 | chr5_77444073_- | intronic |
| ADediting_1213819 | chr5_77444074_- | intronic |
| ADediting_1213820 | chr5_77444093_- | intronic |
| ADediting_1213821 | chr5_77444107_- | intronic |
| ADediting_1213822 | chr5_77444152_- | intronic |
| ADediting_1213823 | chr5_77444153_- | intronic |
| ADediting_1213824 | chr5_77444169_- | intronic |
| ADediting_1213825 | chr5_77444175_- | intronic |
| ADediting_1213826 | chr5_77448683_- | intronic |
| ADediting_1213827 | chr5_77448705_- | intronic |
| ADediting_1213828 | chr5_77448768_- | intronic |
| ADediting_1213829 | chr5_77448785_- | intronic |
| ADediting_1213830 | chr5_77448805_- | intronic |
| ADediting_1213831 | chr5_77481087_- | intronic |
| ADediting_1213832 | chr5_77481147_- | intronic |
| ADediting_1213833 | chr5_77481174_- | intronic |
| ADediting_1213834 | chr5_77481178_- | intronic |
| ADediting_1213835 | chr5_77481198_- | intronic |
| ADediting_1213836 | chr5_77481211_- | intronic |
| ADediting_1213837 | chr5_77481237_- | intronic |
| ADediting_1213838 | chr5_77481242_- | intronic |
| ADediting_1213839 | chr5_77481243_- | intronic |
| ADediting_1213840 | chr5_77481259_- | intronic |
| ADediting_1213841 | chr5_77481272_- | intronic |
| ADediting_1213842 | chr5_77481281_- | intronic |
| ADediting_1581937 | chr5_77442728_- | intronic |
| ADediting_1657948 | chr5_77481060_- | intronic |
| ADediting_1657949 | chr5_77481084_- | intronic |
| ADediting_1657950 | chr5_77481107_- | intronic |
| ADediting_1657951 | chr5_77481121_- | intronic |
| ADediting_1657952 | chr5_77481530_- | intronic |
| ADediting_1657953 | chr5_77481637_- | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_1213797 | chr5_77442648_- | SINE | Alu | Name=AluY |
| ADediting_1213798 | chr5_77442649_- | SINE | Alu | Name=AluY |
| ADediting_1213799 | chr5_77442703_- | SINE | Alu | Name=AluY |
| ADediting_1213801 | chr5_77443930_- | SINE | Alu | Name=AluSx |
| ADediting_1213802 | chr5_77443935_- | SINE | Alu | Name=AluSx |
| ADediting_1213803 | chr5_77443950_- | SINE | Alu | Name=AluSx |
| ADediting_1213804 | chr5_77443951_- | SINE | Alu | Name=AluSx |
| ADediting_1213805 | chr5_77443959_- | SINE | Alu | Name=AluSx |
| ADediting_1213806 | chr5_77443961_- | SINE | Alu | Name=AluSx |
| ADediting_1213807 | chr5_77443992_- | SINE | Alu | Name=AluSx |
| ADediting_1213808 | chr5_77444005_- | SINE | Alu | Name=AluSx |
| ADediting_1213809 | chr5_77444019_- | SINE | Alu | Name=AluSx |
| ADediting_1213810 | chr5_77444041_- | SINE | Alu | Name=AluSx |
| ADediting_1213811 | chr5_77444045_- | SINE | Alu | Name=AluSx |
| ADediting_1213812 | chr5_77444051_- | SINE | Alu | Name=AluSx |
| ADediting_1213813 | chr5_77444054_- | SINE | Alu | Name=AluSx |
| ADediting_1213814 | chr5_77444058_- | SINE | Alu | Name=AluSx |
| ADediting_1213815 | chr5_77444059_- | SINE | Alu | Name=AluSx |
| ADediting_1213816 | chr5_77444060_- | SINE | Alu | Name=AluSx |
| ADediting_1213817 | chr5_77444063_- | SINE | Alu | Name=AluSx |
| ADediting_1213818 | chr5_77444073_- | SINE | Alu | Name=AluSx |
| ADediting_1213819 | chr5_77444074_- | SINE | Alu | Name=AluSx |
| ADediting_1213820 | chr5_77444093_- | SINE | Alu | Name=AluSx |
| ADediting_1213821 | chr5_77444107_- | SINE | Alu | Name=AluSx |
| ADediting_1213822 | chr5_77444152_- | SINE | Alu | Name=AluSx |
| ADediting_1213823 | chr5_77444153_- | SINE | Alu | Name=AluSx |
| ADediting_1213824 | chr5_77444169_- | SINE | Alu | Name=AluSx |
| ADediting_1213825 | chr5_77444175_- | SINE | Alu | Name=AluSx |
| ADediting_1213826 | chr5_77448683_- | SINE | Alu | Name=AluSx4 |
| ADediting_1213827 | chr5_77448705_- | SINE | Alu | Name=AluSx4 |
| ADediting_1213828 | chr5_77448768_- | SINE | Alu | Name=AluSx4 |
| ADediting_1213829 | chr5_77448785_- | SINE | Alu | Name=AluSx4 |
| ADediting_1213830 | chr5_77448805_- | SINE | Alu | Name=AluSx4 |
| ADediting_1213831 | chr5_77481087_- | SINE | Alu | Name=AluSg |
| ADediting_1213832 | chr5_77481147_- | SINE | Alu | Name=AluSg |
| ADediting_1213833 | chr5_77481174_- | SINE | Alu | Name=AluSg |
| ADediting_1213834 | chr5_77481178_- | SINE | Alu | Name=AluSg |
| ADediting_1213835 | chr5_77481198_- | SINE | Alu | Name=AluSg |
| ADediting_1213836 | chr5_77481211_- | SINE | Alu | Name=AluSg |
| ADediting_1213837 | chr5_77481237_- | SINE | Alu | Name=AluSg |
| ADediting_1213838 | chr5_77481242_- | SINE | Alu | Name=AluSg |
| ADediting_1213839 | chr5_77481243_- | SINE | Alu | Name=AluSg |
| ADediting_1213840 | chr5_77481259_- | SINE | Alu | Name=AluSg |
| ADediting_1213841 | chr5_77481272_- | SINE | Alu | Name=AluSg |
| ADediting_1213842 | chr5_77481281_- | SINE | Alu | Name=AluSg |
| ADediting_1581937 | chr5_77442728_- | SINE | Alu | Name=AluY |
| ADediting_1657948 | chr5_77481060_- | SINE | Alu | Name=AluSg |
| ADediting_1657949 | chr5_77481084_- | SINE | Alu | Name=AluSg |
| ADediting_1657950 | chr5_77481107_- | SINE | Alu | Name=AluSg |
| ADediting_1657951 | chr5_77481121_- | SINE | Alu | Name=AluSg |
| ADediting_1657952 | chr5_77481530_- | SINE | Alu | Name=AluSx4 |
| ADediting_1657953 | chr5_77481637_- | SINE | Alu | Name=AluSx4 |
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RNA A-to-I editing events in the alternative splicing sites for WDR41 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for WDR41 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for WDR41 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for WDR41 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1391023 | chr8_140732605_- | ENSG00000164253.14 | ENST00000296679.9 | WDR41-201 | hsa-miR-151a-3p | chr5 | 77433022 | 77433028 | 7mer-m8 | 77433021 | 77433041 | 145 | -13.77 |
| ADediting_1391023 | chr8_140732605_- | ENSG00000164253.14 | ENST00000507029.5 | WDR41-208 | hsa-miR-151a-3p | chr5 | 77433022 | 77433028 | 7mer-m8 | 77433021 | 77433041 | 145 | -13.77 |
| ADediting_1391023 | chr8_140732605_- | ENSG00000164253.14 | ENST00000515253.5 | WDR41-227 | hsa-miR-151a-3p | chr5 | 77433022 | 77433028 | 7mer-m8 | 77433021 | 77433041 | 145 | -13.77 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000164253.14 | ENST00000296679.9 | WDR41-201 | hsa-miR-381-3p | chr5 | 77432573 | 77432579 | 7mer-m8 | 77432572 | 77432593 | 140 | -14.53 |
| ADediting_291761 | chr11_93733708_- | ENSG00000164253.14 | ENST00000296679.9 | WDR41-201 | hsa-miR-1304-3p | chr5 | 77431337 | 77431343 | 7mer-m8 | 77431336 | 77431357 | 162 | -20.88 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000164253.14 | ENST00000296679.9 | WDR41-201 | hsa-miR-4477b | chr5 | 77431244 | 77431251 | 8mer-1a | 77431244 | 77431263 | 144 | -10.86 |
| ADediting_1471004 | chr9_63819627_+ | ENSG00000164253.14 | ENST00000296679.9 | WDR41-201 | hsa-miR-4477b | chr5 | 77431244 | 77431251 | 8mer-1a | 77431244 | 77431263 | 144 | -10.86 |
| ADediting_1596844 | chr1_162342605_+ | ENSG00000164253.14 | ENST00000296679.9 | WDR41-201 | hsa-miR-556-3p | chr5 | 77432827 | 77432833 | 7mer-m8 | 77432826 | 77432848 | 151 | -11.96 |
| ADediting_1596844 | chr1_162342605_+ | ENSG00000164253.14 | ENST00000515253.5 | WDR41-227 | hsa-miR-556-3p | chr5 | 77432827 | 77432833 | 7mer-m8 | 77432826 | 77432848 | 151 | -11.96 |
| ADediting_1643790 | chr3_121049689_+ | ENSG00000164253.14 | ENST00000296679.9 | WDR41-201 | hsa-miR-5682 | chr5 | 77432266 | 77432273 | 8mer-1a | 77432266 | 77432286 | 154 | -18.02 |
| ADediting_286380 | chr11_79422188_- | ENSG00000164253.14 | ENST00000296679.9 | WDR41-201 | hsa-miR-5579-3p | chr5 | 77431806 | 77431812 | 7mer-m8 | 77431805 | 77431826 | 151 | -12.01 |
| ADediting_98288 | chr1_32086990_+ | ENSG00000164253.14 | ENST00000296679.9 | WDR41-201 | hsa-miR-5585-3p | chr5 | 77431626 | 77431633 | 8mer-1a | 77431626 | 77431648 | 147 | -11 |
| ADediting_98289 | chr1_32086992_+ | ENSG00000164253.14 | ENST00000296679.9 | WDR41-201 | hsa-miR-5585-3p | chr5 | 77431626 | 77431633 | 8mer-1a | 77431626 | 77431648 | 147 | -11 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for WDR41 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for WDR41 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | ADediting_1213810 | chr5_77444041_- | 0.600035491063173 | -0.0298951608023828 | 0.129572234950792 | -0.0862790746251881 | 2.67971628241223e-09 | 0.329775166875575 |
| DLPFC | ADediting_1213816 | chr5_77444060_- | 0.590792447466701 | 0.0306552892539029 | 0.448060484229101 | -0.0432430959258595 | 2.32842868353286e-09 | 0.330975241289176 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 1.9620410480982e-77 | 0.822406462810836 | 4.3267732214555e-42 | 0.672091459119429 | 0.000757960913210599 | 0.190290983187642 |
| AC | 1.25589813670007e-100 | 0.916440163707179 | 8.55065437247793e-57 | 0.799372428355776 | 5.84650718296248e-12 | 0.417399087145103 |
| PCC | 5.93373785796687e-51 | 0.835145289297324 | 3.40572324186263e-46 | 0.81263122921295 | 0.0191463165218971 | 0.169394722060524 |
| CER | 1.91838501872681e-45 | 0.861657993467929 | 3.45992683191398e-18 | 0.633257233549463 | 0.0499934086830944 | 0.160339333666179 |
| TCX | 6.16100343832307e-51 | 0.884784348704542 | 3.2092944910966e-12 | 0.529598420576145 | 0.005031824874833 | 0.227910847107619 |
| FP | 2.54125702754197e-19 | 0.607298983864673 | 4.70046091041859e-25 | 0.675348730924058 | 0.236338510477395 | 0.089210089895694 |
| IFG | 1.09589483693077e-06 | 0.806989707831263 | 0.000363687661055354 | 0.656632605420832 | 0.129883266451753 | 0.311265515493282 |
| PG | 3.75733251801852e-55 | 0.858086288650357 | 4.63612165428138e-26 | 0.674732770255368 | 0.869622639361882 | -0.0121164085026237 |
| STG | 4.00259605368374e-17 | 0.761718622420799 | 1.25097647872561e-12 | 0.679055482379315 | 0.832947732025001 | 0.0233604247228203 |
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Relation with AD stages for WDR41 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| STG | 0.00334322777514854 | -0.316620127778718 |
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RelatedDrugs for WDR41 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for WDR41 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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