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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited versus non-edited samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with AD stages

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene


Gene summary for PPP2R1B

check button Gene summary
Gene informationGene symbol

PPP2R1B

Gene ID

5519

Gene nameprotein phosphatase 2 scaffold subunit Abeta
SynonymsPP2A-Abeta|PR65B
Cytomap

11q23.1

Type of geneprotein-coding
Descriptionserine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoformPP2A, subunit A, PR65-beta isoformPP2A, subunit A, R1-beta isoformprotein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoformprotein phosphatase 2, regulatory
Modification date20200313
UniProtAcc

P30154,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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RNA A-to-I events for PPP2R1B

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_232596(111740285, -), ADediting_232597(111740342, -), ADediting_232598(111740346, -), ADediting_232599(111740350, -), ADediting_232600(111740356, -), ADediting_232601(111740393, -), ADediting_232602(111740395, -), ADediting_232603(111740399, -), ADediting_232604(111740423, -), ADediting_232605(111740443, -), ADediting_232606(111740446, -), ADediting_232607(111749389, -), ADediting_232608(111750429, -), ADediting_232609(111750430, -), ADediting_232610(111750869, -), ADediting_232611(111750906, -), ADediting_232612(111750923, -), ADediting_232613(111750931, -), ADediting_232614(111750944, -), ADediting_232615(111750954, -), ADediting_232616(111750967, -), ADediting_232617(111750977, -), ADediting_232618(111751003, -), ADediting_232619(111751021, -), ADediting_232620(111751032, -), ADediting_232621(111751042, -), ADediting_232622(111751066, -), ADediting_232623(111751085, -), ADediting_232624(111751118, -), ADediting_232625(111751733, -), ADediting_232626(111751743, -), ADediting_232627(111751761, -), ADediting_232628(111751786, -), ADediting_232629(111751868, -), ADediting_232630(111751877, -), ADediting_232631(111751894, -), ADediting_232632(111751895, -), ADediting_232633(111751908, -), ADediting_232634(111751930, -), ADediting_232635(111751938, -), ADediting_232636(111751964, -), ADediting_232637(111751977, -), ADediting_232638(111755625, -), ADediting_232639(111755636, -), ADediting_232640(111755637, -), ADediting_232641(111755642, -), ADediting_232642(111755647, -), ADediting_232643(111755665, -), ADediting_232644(111755666, -), ADediting_232645(111755692, -), ADediting_232646(111755701, -), ADediting_232647(111755718, -), ADediting_232648(111755722, -), ADediting_232649(111755727, -), ADediting_232650(111755728, -), ADediting_232651(111755754, -), ADediting_232652(111755757, -), ADediting_232653(111755760, -), ADediting_232654(111755763, -), ADediting_232655(111755766, -), ADediting_232656(111755768, -), ADediting_232657(111755769, -), ADediting_232658(111755772, -), ADediting_232659(111755783, -), ADediting_232660(111755784, -), ADediting_232661(111755785, -), ADediting_232662(111755793, -), ADediting_232663(111755794, -), ADediting_232664(111755836, -), ADediting_232665(111755892, -), ADediting_232666(111755952, -), ADediting_232667(111755974, -), ADediting_232668(111756019, -), ADediting_232669(111756044, -), ADediting_232670(111756123, -), ADediting_232671(111756147, -), ADediting_232672(111756196, -), ADediting_232673(111757028, -), ADediting_232674(111757752, -), ADediting_232675(111757799, -), ADediting_232676(111758424, -), ADediting_232677(111758427, -), ADediting_232678(111758433, -), ADediting_232679(111758446, -), ADediting_232680(111758468, -), ADediting_232681(111758474, -), ADediting_232682(111758482, -), ADediting_232683(111758503, -), ADediting_232684(111758504, -), ADediting_232685(111758507, -), ADediting_232686(111758567, -), ADediting_232687(111758575, -), ADediting_232688(111761877, -), ADediting_232689(111761938, -), ADediting_232690(111762818, -), ADediting_1525445(111740329, -), ADediting_1525446(111749010, -), ADediting_1525447(111749027, -), ADediting_1525448(111749117, -), ADediting_1525449(111749451, -), ADediting_1525450(111756172, -), ADediting_1525451(111756177, -), ADediting_1525452(111756184, -), ADediting_1525453(111756202, -), ADediting_1525454(111758347, -), ADediting_1525455(111758543, -), ADediting_1525456(111758564, -),

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RNA editing positional annotations for PPP2R1B using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_232596chr11_111740285_-UTR3
ADediting_232597chr11_111740342_-UTR3
ADediting_232598chr11_111740346_-UTR3
ADediting_232599chr11_111740350_-UTR3
ADediting_232600chr11_111740356_-UTR3
ADediting_232601chr11_111740393_-UTR3
ADediting_232602chr11_111740395_-UTR3
ADediting_232603chr11_111740399_-UTR3
ADediting_232604chr11_111740423_-UTR3
ADediting_232605chr11_111740443_-UTR3
ADediting_232606chr11_111740446_-UTR3
ADediting_232607chr11_111749389_-intronic
ADediting_232608chr11_111750429_-intronic
ADediting_232609chr11_111750430_-intronic
ADediting_232610chr11_111750869_-intronic
ADediting_232611chr11_111750906_-intronic
ADediting_232612chr11_111750923_-intronic
ADediting_232613chr11_111750931_-intronic
ADediting_232614chr11_111750944_-intronic
ADediting_232615chr11_111750954_-intronic
ADediting_232616chr11_111750967_-intronic
ADediting_232617chr11_111750977_-intronic
ADediting_232618chr11_111751003_-intronic
ADediting_232619chr11_111751021_-intronic
ADediting_232620chr11_111751032_-intronic
ADediting_232621chr11_111751042_-intronic
ADediting_232622chr11_111751066_-intronic
ADediting_232623chr11_111751085_-intronic
ADediting_232624chr11_111751118_-intronic
ADediting_232625chr11_111751733_-intronic
ADediting_232626chr11_111751743_-intronic
ADediting_232627chr11_111751761_-intronic
ADediting_232628chr11_111751786_-intronic
ADediting_232629chr11_111751868_-intronic
ADediting_232630chr11_111751877_-intronic
ADediting_232631chr11_111751894_-intronic
ADediting_232632chr11_111751895_-intronic
ADediting_232633chr11_111751908_-intronic
ADediting_232634chr11_111751930_-intronic
ADediting_232635chr11_111751938_-intronic
ADediting_232636chr11_111751964_-intronic
ADediting_232637chr11_111751977_-intronic
ADediting_232638chr11_111755625_-intronic
ADediting_232639chr11_111755636_-intronic
ADediting_232640chr11_111755637_-intronic
ADediting_232641chr11_111755642_-intronic
ADediting_232642chr11_111755647_-intronic
ADediting_232643chr11_111755665_-intronic
ADediting_232644chr11_111755666_-intronic
ADediting_232645chr11_111755692_-intronic
ADediting_232646chr11_111755701_-intronic
ADediting_232647chr11_111755718_-intronic
ADediting_232648chr11_111755722_-intronic
ADediting_232649chr11_111755727_-intronic
ADediting_232650chr11_111755728_-intronic
ADediting_232651chr11_111755754_-intronic
ADediting_232652chr11_111755757_-intronic
ADediting_232653chr11_111755760_-intronic
ADediting_232654chr11_111755763_-intronic
ADediting_232655chr11_111755766_-intronic
ADediting_232656chr11_111755768_-intronic
ADediting_232657chr11_111755769_-intronic
ADediting_232658chr11_111755772_-intronic
ADediting_232659chr11_111755783_-intronic
ADediting_232660chr11_111755784_-intronic
ADediting_232661chr11_111755785_-intronic
ADediting_232662chr11_111755793_-intronic
ADediting_232663chr11_111755794_-intronic
ADediting_232664chr11_111755836_-intronic
ADediting_232665chr11_111755892_-intronic
ADediting_232666chr11_111755952_-intronic
ADediting_232667chr11_111755974_-intronic
ADediting_232668chr11_111756019_-intronic
ADediting_232669chr11_111756044_-intronic
ADediting_232670chr11_111756123_-intronic
ADediting_232671chr11_111756147_-intronic
ADediting_232672chr11_111756196_-intronic
ADediting_232673chr11_111757028_-intronic
ADediting_232674chr11_111757752_-intronic
ADediting_232675chr11_111757799_-intronic
ADediting_232676chr11_111758424_-intronic
ADediting_232677chr11_111758427_-intronic
ADediting_232678chr11_111758433_-intronic
ADediting_232679chr11_111758446_-intronic
ADediting_232680chr11_111758468_-intronic
ADediting_232681chr11_111758474_-intronic
ADediting_232682chr11_111758482_-intronic
ADediting_232683chr11_111758503_-intronic
ADediting_232684chr11_111758504_-intronic
ADediting_232685chr11_111758507_-intronic
ADediting_232686chr11_111758567_-intronic
ADediting_232687chr11_111758575_-intronic
ADediting_232688chr11_111761877_-intronic
ADediting_232689chr11_111761938_-intronic
ADediting_232690chr11_111762818_-intronic
ADediting_1525445chr11_111740329_-UTR3
ADediting_1525446chr11_111749010_-intronic
ADediting_1525447chr11_111749027_-intronic
ADediting_1525448chr11_111749117_-intronic
ADediting_1525449chr11_111749451_-intronic
ADediting_1525450chr11_111756172_-intronic
ADediting_1525451chr11_111756177_-intronic
ADediting_1525452chr11_111756184_-intronic
ADediting_1525453chr11_111756202_-intronic
ADediting_1525454chr11_111758347_-intronic
ADediting_1525455chr11_111758543_-intronic
ADediting_1525456chr11_111758564_-intronic

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_232596chr11_111740285_-SINEAluName=AluSz
ADediting_232597chr11_111740342_-SINEAluName=AluSz
ADediting_232598chr11_111740346_-SINEAluName=AluSz
ADediting_232599chr11_111740350_-SINEAluName=AluSz
ADediting_232600chr11_111740356_-SINEAluName=AluSz
ADediting_232601chr11_111740393_-SINEAluName=AluSz
ADediting_232602chr11_111740395_-SINEAluName=AluSz
ADediting_232603chr11_111740399_-SINEAluName=AluSz
ADediting_232604chr11_111740423_-SINEAluName=AluSz
ADediting_232605chr11_111740443_-SINEAluName=AluSz
ADediting_232606chr11_111740446_-SINEAluName=AluSz
ADediting_232607chr11_111749389_-SINEAluName=AluSx1
ADediting_232608chr11_111750429_-SINEAluName=FLAM_C
ADediting_232609chr11_111750430_-SINEAluName=FLAM_C
ADediting_232610chr11_111750869_-SINEAluName=AluSz
ADediting_232611chr11_111750906_-SINEAluName=AluSz
ADediting_232612chr11_111750923_-SINEAluName=AluSz
ADediting_232613chr11_111750931_-SINEAluName=AluSz
ADediting_232614chr11_111750944_-SINEAluName=AluSz
ADediting_232615chr11_111750954_-SINEAluName=AluSz
ADediting_232616chr11_111750967_-SINEAluName=AluSz
ADediting_232617chr11_111750977_-SINEAluName=AluSz
ADediting_232618chr11_111751003_-SINEAluName=AluSz
ADediting_232619chr11_111751021_-SINEAluName=AluSz
ADediting_232620chr11_111751032_-SINEAluName=AluSz
ADediting_232621chr11_111751042_-SINEAluName=AluSz
ADediting_232622chr11_111751066_-SINEAluName=AluSz
ADediting_232623chr11_111751085_-SINEAluName=AluSz
ADediting_232624chr11_111751118_-SINEAluName=AluSz
ADediting_232625chr11_111751733_-SINEAluName=AluSq2
ADediting_232626chr11_111751743_-SINEAluName=AluSq2
ADediting_232627chr11_111751761_-SINEAluName=AluSq2
ADediting_232628chr11_111751786_-SINEAluName=AluSq2
ADediting_232629chr11_111751868_-SINEAluName=AluSq2
ADediting_232630chr11_111751877_-SINEAluName=AluSq2
ADediting_232631chr11_111751894_-SINEAluName=AluSq2
ADediting_232632chr11_111751895_-SINEAluName=AluSq2
ADediting_232633chr11_111751908_-SINEAluName=AluSq2
ADediting_232634chr11_111751930_-SINEAluName=AluSq2
ADediting_232635chr11_111751938_-SINEAluName=AluSq2
ADediting_232636chr11_111751964_-SINEAluName=AluSq2
ADediting_232637chr11_111751977_-SINEAluName=AluSq2
ADediting_232638chr11_111755625_-SINEAluName=AluSz
ADediting_232639chr11_111755636_-SINEAluName=AluSz
ADediting_232640chr11_111755637_-SINEAluName=AluSz
ADediting_232641chr11_111755642_-SINEAluName=AluSz
ADediting_232642chr11_111755647_-SINEAluName=AluSz
ADediting_232643chr11_111755665_-SINEAluName=AluSz
ADediting_232644chr11_111755666_-SINEAluName=AluSz
ADediting_232645chr11_111755692_-SINEAluName=AluSz
ADediting_232646chr11_111755701_-SINEAluName=AluSz
ADediting_232647chr11_111755718_-SINEAluName=AluSz
ADediting_232648chr11_111755722_-SINEAluName=AluSz
ADediting_232649chr11_111755727_-SINEAluName=AluSz
ADediting_232650chr11_111755728_-SINEAluName=AluSz
ADediting_232651chr11_111755754_-SINEAluName=AluSz
ADediting_232652chr11_111755757_-SINEAluName=AluSz
ADediting_232653chr11_111755760_-SINEAluName=AluSz
ADediting_232654chr11_111755763_-SINEAluName=AluSz
ADediting_232655chr11_111755766_-SINEAluName=AluSz
ADediting_232656chr11_111755768_-SINEAluName=AluSz
ADediting_232657chr11_111755769_-SINEAluName=AluSz
ADediting_232658chr11_111755772_-SINEAluName=AluSz
ADediting_232659chr11_111755783_-SINEAluName=AluSz
ADediting_232660chr11_111755784_-SINEAluName=AluSz
ADediting_232661chr11_111755785_-SINEAluName=AluSz
ADediting_232662chr11_111755793_-SINEAluName=AluSz
ADediting_232663chr11_111755794_-SINEAluName=AluSz
ADediting_232664chr11_111755836_-SINEAluName=AluSz
ADediting_232665chr11_111755892_-SINEAluName=AluSz
ADediting_232666chr11_111755952_-SINEAluName=AluY
ADediting_232667chr11_111755974_-SINEAluName=AluY
ADediting_232668chr11_111756019_-SINEAluName=AluY
ADediting_232669chr11_111756044_-SINEAluName=AluY
ADediting_232670chr11_111756123_-SINEAluName=AluY
ADediting_232671chr11_111756147_-SINEAluName=AluY
ADediting_232672chr11_111756196_-SINEAluName=AluY
ADediting_232673chr11_111757028_-SINEAluName=AluSx
ADediting_232674chr11_111757752_-SINEAluName=AluSq2
ADediting_232675chr11_111757799_-SINEAluName=AluSq2
ADediting_232676chr11_111758424_-SINEAluName=AluSc
ADediting_232677chr11_111758427_-SINEAluName=AluSc
ADediting_232678chr11_111758433_-SINEAluName=AluSc
ADediting_232679chr11_111758446_-SINEAluName=AluSc
ADediting_232680chr11_111758468_-SINEAluName=AluSc
ADediting_232681chr11_111758474_-SINEAluName=AluSc
ADediting_232682chr11_111758482_-SINEAluName=AluSc
ADediting_232683chr11_111758503_-SINEAluName=AluSc
ADediting_232684chr11_111758504_-SINEAluName=AluSc
ADediting_232685chr11_111758507_-SINEAluName=AluSc
ADediting_232686chr11_111758567_-SINEAluName=AluSc
ADediting_232687chr11_111758575_-SINEAluName=AluSc
ADediting_232688chr11_111761877_-SINEAluName=AluSz
ADediting_232689chr11_111761938_-SINEAluName=AluSz
ADediting_232690chr11_111762818_-SINEAluName=AluJr
ADediting_1525445chr11_111740329_-SINEAluName=AluSz
ADediting_1525446chr11_111749010_-SINEAluName=AluSx
ADediting_1525447chr11_111749027_-SINEAluName=AluSx
ADediting_1525448chr11_111749117_-SINEAluName=AluSx
ADediting_1525449chr11_111749451_-SINEAluName=AluSx1
ADediting_1525450chr11_111756172_-SINEAluName=AluY
ADediting_1525451chr11_111756177_-SINEAluName=AluY
ADediting_1525452chr11_111756184_-SINEAluName=AluY
ADediting_1525453chr11_111756202_-SINEAluName=AluY
ADediting_1525454chr11_111758347_-SINEAluName=AluSc
ADediting_1525455chr11_111758543_-SINEAluName=AluSc
ADediting_1525456chr11_111758564_-SINEAluName=AluSc

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RNA A-to-I editing events in the alternative splicing sites for PPP2R1B

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for PPP2R1B

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
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check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
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check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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ADeditome IDChrPositoingSkipped exonENSGENSTs

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Protein coding region RNA A-to-I editings for PPP2R1B

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for PPP2R1B

check buttonRNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
all structure

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_232598chr11_111740346_-ENSG00000137713.16ENST00000527614.6PPP2R1B-206hsa-miR-1207-3pchr111117403461117403527mer-m8111740345111740363145-13.53
ADediting_232598chr11_111740346_-ENSG00000137713.16ENST00000527614.6PPP2R1B-206hsa-miR-646chr111117403441117403507mer-m8111740343111740362148-20.6
ADediting_232600chr11_111740356_-ENSG00000137713.16ENST00000527614.6PPP2R1B-206hsa-miR-140-3pchr111117403541117403607mer-m8111740353111740373156-22.58
ADediting_232601chr11_111740393_-ENSG00000137713.16ENST00000527614.6PPP2R1B-206hsa-miR-153-5pchr111117403931117403997mer-m8111740392111740414148-8.16
ADediting_232601chr11_111740393_-ENSG00000137713.16ENST00000527614.6PPP2R1B-206hsa-miR-3680-3pchr111117403881117403958mer-1a111740388111740410140-14.24
ADediting_232603chr11_111740399_-ENSG00000137713.16ENST00000527614.6PPP2R1B-206hsa-miR-222-5pchr111117403971117404048mer-1a111740397111740417141-9.81
ADediting_232603chr11_111740399_-ENSG00000137713.16ENST00000527614.6PPP2R1B-206hsa-miR-30a-3pchr111117403951117404028mer-1a111740395111740419154-11.94
ADediting_232603chr11_111740399_-ENSG00000137713.16ENST00000527614.6PPP2R1B-206hsa-miR-30d-3pchr111117403951117404028mer-1a111740395111740417153-12.1
ADediting_232603chr11_111740399_-ENSG00000137713.16ENST00000527614.6PPP2R1B-206hsa-miR-30e-3pchr111117403951117404028mer-1a111740395111740419154-14
ADediting_232603chr11_111740399_-ENSG00000137713.16ENST00000527614.6PPP2R1B-206hsa-miR-936chr111117403981117404058mer-1a111740398111740420159-22.75
ADediting_232604chr11_111740423_-ENSG00000137713.16ENST00000527614.6PPP2R1B-206hsa-miR-6131chr111117404211117404288mer-1a111740421111740439151-20.37
ADediting_232605chr11_111740443_-ENSG00000137713.16ENST00000527614.6PPP2R1B-206hsa-miR-4680-5pchr111117404401117404467mer-m8111740439111740459166-23.25
ADediting_232606chr11_111740446_-ENSG00000137713.16ENST00000527614.6PPP2R1B-206hsa-miR-378a-5pchr111117404431117404508mer-1a111740443111740464155-21.17

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1525445chr11_111740329_-ENSG00000137713.16ENST00000527614.6PPP2R1B-206hsa-miR-1976chr111117403241117403318mer-1a111740324111740344153-25.04
ADediting_1525445chr11_111740329_-ENSG00000137713.16ENST00000527614.6PPP2R1B-206hsa-miR-6747-3pchr111117403261117403338mer-1a111740326111740348149-23.42
ADediting_232596chr11_111740285_-ENSG00000137713.16ENST00000527614.6PPP2R1B-206hsa-miR-4638-5pchr111117402831117402908mer-1a111740283111740302154-23.82
ADediting_232597chr11_111740342_-ENSG00000137713.16ENST00000527614.6PPP2R1B-206hsa-miR-1200chr111117403391117403457mer-m8111740338111740359141-18.61
ADediting_232597chr11_111740342_-ENSG00000137713.16ENST00000527614.6PPP2R1B-206hsa-miR-6869-5pchr111117403421117403487mer-m8111740341111740364152-19.66
ADediting_232598chr11_111740346_-ENSG00000137713.16ENST00000527614.6PPP2R1B-206hsa-miR-6869-5pchr111117403421117403487mer-m8111740341111740364152-19.66
ADediting_232604chr11_111740423_-ENSG00000137713.16ENST00000527614.6PPP2R1B-206hsa-miR-4716-5pchr111117404181117404247mer-m8111740417111740438140-9.49
ADediting_232604chr11_111740423_-ENSG00000137713.16ENST00000527614.6PPP2R1B-206hsa-miR-4781-3pchr111117404201117404267mer-m8111740419111740440140-12.59
ADediting_232605chr11_111740443_-ENSG00000137713.16ENST00000527614.6PPP2R1B-206hsa-miR-10393-5pchr111117404401117404467mer-m8111740439111740462153-10.91

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1556067chr19_40282625_-ENSG00000137713.16ENST00000527614.6PPP2R1B-206hsa-miR-641chr111117380771117380837mer-m8111738076111738102152-18.53
ADediting_1556067chr19_40282625_-ENSG00000137713.16ENST00000527614.6PPP2R1B-206hsa-miR-641chr111117388511117388588mer-1a111738851111738874140-12.09

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_107020chr1_37500952_-ENSG00000137713.16ENST00000527614.6PPP2R1B-206hsa-miR-5581-3pchr111117391391117391468mer-1a111739139111739161149-11.74
ADediting_1097295chr3_85385762_+ENSG00000137713.16ENST00000527614.6PPP2R1B-206hsa-miR-5688chr111117408201117408267mer-m8111740819111740841149-11.93
ADediting_1337757chr7_5495852_-ENSG00000137713.16ENST00000527614.6PPP2R1B-206hsa-miR-589-3pchr111117400501117400567mer-m8111740049111740072140-12.52
ADediting_291761chr11_93733708_-ENSG00000137713.16ENST00000527614.6PPP2R1B-206hsa-miR-1304-3pchr111117395981117396047mer-m8111739597111739619148-14.71
ADediting_496066chr15_66496985_-ENSG00000137713.16ENST00000527614.6PPP2R1B-206hsa-miR-4512chr111117382141117382207mer-m8111738213111738234152-24.34
ADediting_527135chr16_24203190_+ENSG00000137713.16ENST00000527614.6PPP2R1B-206hsa-miR-1273h-3pchr111117399191117399257mer-m8111739918111739941147-18.43
ADediting_527135chr16_24203190_+ENSG00000137713.16ENST00000527614.6PPP2R1B-206hsa-miR-1273h-3pchr111117410731117410797mer-m8111741072111741093141-15.53

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for PPP2R1B

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.
ENST00000527614.6protein_codingSoverviewSoverview

check button RNA A-to-I editing in miRNA.
ADeditom_IDENSTmir_IDEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in mRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI
ADediting_232596ENST00000527614.6chr11_111740285_-3145-1577.10-1576.90-1588.30
ADediting_1525445ENST00000527614.6chr11_111740329_-3101-1576.50-1576.90-1588.30
ADediting_232597ENST00000527614.6chr11_111740342_-3088-1576.90-1576.90-1588.30
ADediting_232598ENST00000527614.6chr11_111740346_-3084-1577.40-1576.90-1588.30
ADediting_232599ENST00000527614.6chr11_111740350_-3080-1576.20-1576.90-1588.30
ADediting_232600ENST00000527614.6chr11_111740356_-3074-1576.90-1576.90-1588.30
ADediting_232601ENST00000527614.6chr11_111740393_-3037-1576.90-1576.90-1588.30
ADediting_232602ENST00000527614.6chr11_111740395_-3035-1578.50-1576.90-1588.30
ADediting_232603ENST00000527614.6chr11_111740399_-3031-1577.20-1576.90-1588.30
ADediting_232604ENST00000527614.6chr11_111740423_-3007-1577.30-1576.90-1588.30
ADediting_232605ENST00000527614.6chr11_111740443_-2987-1577.50-1576.90-1588.30
ADediting_232606ENST00000527614.6chr11_111740446_-2984-1582.30-1576.90-1588.30

check button RNA A-to-I editing in lncRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for PPP2R1B

check button Correlation between ADAR gene expression and RNA editing frequency
TissueADeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFCADediting_232638chr11_111755625_-0.5699484945613610.03238984486774510.130220632200327-0.08613398785798252.25371078422127e-240.535208518594621
DLPFCADediting_232639chr11_111755636_-0.8415733213999220.01139817892445970.125670233094106-0.08716425613453381.22399124612427e-140.419425676417293
DLPFCADediting_232645chr11_111755692_-0.1146325614641140.0897894736805140.9194453234700840.005767187130416621.288584424878e-120.388618402008635
DLPFCADediting_232646chr11_111755701_-0.7148677797933560.02083104542235720.158965127608788-0.0801959341489311.12000153945112e-130.40517516079262
DLPFCADediting_232649chr11_111755727_-0.3550923181630410.05269905447806060.247938844969436-0.06581532735606551.00177023707208e-170.461108547198939
DLPFCADediting_232650chr11_111755728_-0.205704785831680.07207121759189280.72294784995943-0.02021509293929256.21011909027347e-110.360277290953192
DLPFCADediting_232662chr11_111755793_-0.270801799306920.06273678968656640.403128026080668-0.04764983831926881.02806799178144e-130.405739284017014
DLPFCADediting_232663chr11_111755794_-0.1251866361801520.08727543847492490.532990677982668-0.03554181333156683.0469113436346e-170.454950980373587
DLPFCADediting_232667chr11_111755974_-0.2854169640803630.06086096848759410.216568624874754-0.07038052813553212.71372761272588e-250.544164593955692
DLPFCADediting_232681chr11_111758474_-0.2327047807743690.06797790507151870.704927076610409-0.02159217812822741.45851069615357e-110.371198011972892
DLPFCADediting_232682chr11_111758482_-0.05945323027994920.1071753979050270.780909596488485-0.01586001927827691.21960246343328e-080.316489211438185

check button Correlation between ADAR gene expression and this gene's expression
TissueADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFC3.43618640353397e-210.5019664095277322.95362134958244e-110.3659306126937382.78759308911564e-160.442314040519543
AC1.44084255264315e-480.7612994190463851.41097500182946e-260.6071849801675971.15252231447423e-240.588233073552981
PCC1.67581634924503e-080.3942111028084696.98548825487632e-060.3187534577405227.87708796704314e-130.488156094210213
CER2.44076001850917e-300.7671794301343399.72317515312632e-310.7704718433584191.54539426063349e-080.441579220654933
TCX2.39000289221673e-060.3742080105941110.373630110354321-0.07315782377928066.15582015974657e-260.726983731285401
FP5.05663358111176e-100.444610242614141.36126357815087e-080.4096573959395737.46288116705183e-130.50393390232742
IFG0.001939625061311730.5892365960590290.001317902865714920.6062025178188280.0001412381942233180.68864045154504
PG1.27904284560887e-220.6376762347228941.09985190362653e-130.5095980703984410.002534241536051230.220141880184051
STG0.3141008327322270.1111597655358680.628674766778841-0.05352852780278520.005464847062136250.300594212106178

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Relation with AD stages for PPP2R1B

check button Correlation between AD stages and RNA editing frequency
TissueADeditomIDpositionP-valCoeff.
TCXADediting_232686chr11_111758567_-0.001394509279539190.306528725694654

check button Correlation between AD stages and this gene's expression
TissueP-valCoeff.
CER3.62728008979807e-060.428933610508709
TCX8.58702640116371e-110.57816528095919

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RelatedDrugs for PPP2R1B

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PPP2R1B

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource