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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for ANLN |
 Gene summary |
| Gene information | Gene symbol | ANLN | Gene ID | 54443 |
| Gene name | anillin actin binding protein | |
| Synonyms | FSGS8|Scraps|scra | |
| Cytomap | 7p14.2 | |
| Type of gene | protein-coding | |
| Description | anillin | |
| Modification date | 20200313 | |
| UniProtAcc | Q9NQW6, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| ANLN | GO:0000281 | mitotic cytokinesis | 10931866 |
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RNA A-to-I events for ANLN |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_1328737(36401439, +), ADediting_1328738(36401478, +), ADediting_1328739(36432091, +), ADediting_1328740(36432101, +), ADediting_1328741(36444128, +), ADediting_1328755(36448076, +), ADediting_1328756(36448115, +), ADediting_1328757(36448131, +), ADediting_1328758(36448211, +), ADediting_1587392(36431943, +), ADediting_1587393(36431963, +), ADediting_1587394(36431980, +), ADediting_1587395(36432115, +), ADediting_1587396(36434717, +), ADediting_1587397(36434727, +), ADediting_1587398(36438396, +), ADediting_1587399(36444169, +), ADediting_1665785(36429435, +), ADediting_1665786(36429449, +), ADediting_1665787(36429455, +), ADediting_1665788(36434840, +), ADediting_1665789(36444134, +), |
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RNA editing positional annotations for ANLN using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_1328737 | chr7_36401439_+ | intronic |
| ADediting_1328738 | chr7_36401478_+ | intronic |
| ADediting_1328739 | chr7_36432091_+ | intronic |
| ADediting_1328740 | chr7_36432101_+ | intronic |
| ADediting_1328741 | chr7_36444128_+ | intronic |
| ADediting_1328755 | chr7_36448076_+ | intronic |
| ADediting_1328756 | chr7_36448115_+ | intronic |
| ADediting_1328757 | chr7_36448131_+ | intronic |
| ADediting_1328758 | chr7_36448211_+ | intronic |
| ADediting_1587392 | chr7_36431943_+ | intronic |
| ADediting_1587393 | chr7_36431963_+ | intronic |
| ADediting_1587394 | chr7_36431980_+ | intronic |
| ADediting_1587395 | chr7_36432115_+ | intronic |
| ADediting_1587396 | chr7_36434717_+ | intronic |
| ADediting_1587397 | chr7_36434727_+ | intronic |
| ADediting_1587398 | chr7_36438396_+ | intronic |
| ADediting_1587399 | chr7_36444169_+ | intronic |
| ADediting_1665785 | chr7_36429435_+ | intronic |
| ADediting_1665786 | chr7_36429449_+ | intronic |
| ADediting_1665787 | chr7_36429455_+ | intronic |
| ADediting_1665788 | chr7_36434840_+ | intronic |
| ADediting_1665789 | chr7_36444134_+ | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_1328737 | chr7_36401439_+ | SINE | Alu | Name=AluSx |
| ADediting_1328738 | chr7_36401478_+ | SINE | Alu | Name=AluSx |
| ADediting_1328739 | chr7_36432091_+ | SINE | Alu | Name=AluJr |
| ADediting_1328740 | chr7_36432101_+ | SINE | Alu | Name=AluJr |
| ADediting_1328741 | chr7_36444128_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1328755 | chr7_36448076_+ | SINE | Alu | Name=AluSz |
| ADediting_1328756 | chr7_36448115_+ | SINE | Alu | Name=AluSz |
| ADediting_1328757 | chr7_36448131_+ | SINE | Alu | Name=AluSz |
| ADediting_1328758 | chr7_36448211_+ | SINE | Alu | Name=AluSz |
| ADediting_1587392 | chr7_36431943_+ | SINE | Alu | Name=AluJr |
| ADediting_1587393 | chr7_36431963_+ | SINE | Alu | Name=AluJr |
| ADediting_1587394 | chr7_36431980_+ | SINE | Alu | Name=AluJr |
| ADediting_1587395 | chr7_36432115_+ | SINE | Alu | Name=AluJr |
| ADediting_1587396 | chr7_36434717_+ | SINE | Alu | Name=AluSz |
| ADediting_1587397 | chr7_36434727_+ | SINE | Alu | Name=AluSz |
| ADediting_1587398 | chr7_36438396_+ | SINE | Alu | Name=AluJo |
| ADediting_1587399 | chr7_36444169_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1665785 | chr7_36429435_+ | SINE | Alu | Name=AluSx |
| ADediting_1665786 | chr7_36429449_+ | SINE | Alu | Name=AluSx |
| ADediting_1665787 | chr7_36429455_+ | SINE | Alu | Name=AluSx |
| ADediting_1665788 | chr7_36434840_+ | SINE | Alu | Name=AluSz |
| ADediting_1665789 | chr7_36444134_+ | SINE | Alu | Name=AluSx1 |
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RNA A-to-I editing events in the alternative splicing sites for ANLN |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for ANLN |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for ANLN |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for ANLN |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_843620 | chr2_207754818_+ | ENSG00000011426.11 | ENST00000265748.7 | ANLN-201 | hsa-miR-4775 | chr7 | 36453567 | 36453573 | 7mer-m8 | 36453553 | 36453574 | 140 | -4.26 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000011426.11 | ENST00000396068.6 | ANLN-202 | hsa-miR-4775 | chr7 | 36453567 | 36453573 | 7mer-m8 | 36453553 | 36453574 | 140 | -4.26 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for ANLN |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for ANLN |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| TCX | ADediting_1328741 | chr7_36444128_+ | 0.32482512800611 | 0.08093659155641 | 0.162893996127978 | -0.114517076767056 | 9.1594408546826e-08 | 0.419446966183203 |
| TCX | ADediting_1328758 | chr7_36448211_+ | 0.100916686164184 | 0.134456065289193 | 0.171438247586492 | -0.112249612551275 | 2.27606132960582e-14 | 0.571277805263354 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| AC | 5.82106076874797e-33 | 0.662470960380949 | 1.25228127942378e-20 | 0.543652655314307 | 5.74058426924991e-33 | 0.662518264610218 |
| CER | 0.106889393526553 | 0.132173929621445 | 0.180446739330569 | 0.109947891932578 | 1.28664565271957e-05 | 0.347904380687154 |
| TCX | 0.065563352158702 | 0.15075015067683 | 0.000104544657171634 | -0.311472404038135 | 3.18972802855789e-26 | 0.729829960349686 |
| FP | 4.09262270731643e-05 | 0.302373638614702 | 0.000384066026408846 | 0.263287063548859 | 1.01499540448713e-16 | 0.569933963685006 |
| IFG | 0.602467740068496 | 0.109461097632311 | 0.479440269468327 | -0.148245725965161 | 0.000149660671667529 | 0.686787451986894 |
| PG | 7.37224483873492e-27 | 0.682625462150459 | 7.29455557317041e-08 | 0.382239562433489 | 4.80923909434682e-05 | 0.293429713289476 |
| STG | 0.000329987749003274 | 0.382483998470233 | 0.12190180014543 | 0.170090333852271 | 4.93361189251139e-10 | 0.614791072577952 |
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Relation with AD stages for ANLN |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| PCC | 1.38072463580018e-05 | 0.308834913298902 |
| CER | 7.32055219276438e-05 | 0.372123773666503 |
| TCX | 5.96278423271749e-06 | 0.423876931827419 |
| PG | 9.66360553067199e-07 | 0.35009379866548 |
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RelatedDrugs for ANLN |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ANLN |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| ANLN | C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |
| ANLN | C1136382 | Sclerocystic Ovaries | 1 | CTD_human |
| ANLN | C4014993 | FOCAL SEGMENTAL GLOMERULOSCLEROSIS 8 | 1 | UNIPROT |
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