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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for PLSCR1 |
 Gene summary |
| Gene information | Gene symbol | PLSCR1 | Gene ID | 5359 |
| Gene name | phospholipid scramblase 1 | |
| Synonyms | MMTRA1B | |
| Cytomap | 3q24 | |
| Type of gene | protein-coding | |
| Description | phospholipid scramblase 1PL scramblase 1ca(2+)-dependent phospholipid scramblase 1erythrocyte phospholipid scramblase | |
| Modification date | 20200313 | |
| UniProtAcc | O15162, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| PLSCR1 | GO:0006915 | apoptotic process | 10770950 |
| PLSCR1 | GO:0017121 | phospholipid scrambling | 9218461|10770950|18629440 |
| PLSCR1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 16091359 |
| PLSCR1 | GO:2000373 | positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity | 17567603 |
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RNA A-to-I events for PLSCR1 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_1030595(146519255, -), ADediting_1030596(146519314, -), ADediting_1030597(146519333, -), ADediting_1030598(146519697, -), ADediting_1030599(146519732, -), ADediting_1030600(146519742, -), ADediting_1030601(146519780, -), ADediting_1030602(146526043, -), ADediting_1030603(146526998, -), ADediting_1030604(146529543, -), ADediting_1030605(146529610, -), ADediting_1030606(146529637, -), ADediting_1030607(146529641, -), ADediting_1030608(146529651, -), ADediting_1030609(146529719, -), ADediting_1030610(146542248, -), ADediting_1030611(146542252, -), ADediting_1030612(146542259, -), ADediting_1030613(146542266, -), ADediting_1030614(146542270, -), ADediting_1030615(146542306, -), ADediting_1030616(146542333, -), ADediting_1030617(146543056, -), ADediting_1030618(146543061, -), ADediting_1030619(146543063, -), ADediting_1030620(146543098, -), ADediting_1030621(146543102, -), ADediting_1030622(146543112, -), ADediting_1030623(146543116, -), ADediting_1030624(146543151, -), ADediting_1030625(146543157, -), ADediting_1030626(146543176, -), ADediting_1572516(146519694, -), ADediting_1572517(146542346, -), ADediting_1644929(146519740, -), ADediting_1644930(146526010, -), ADediting_1644931(146526055, -), ADediting_1644932(146526071, -), ADediting_1644933(146542293, -), ADediting_1644934(146542313, -), ADediting_1644935(146543074, -), ADediting_1644936(146543120, -), ADediting_1644937(146543125, -), ADediting_1644938(146543134, -), ADediting_1644939(146543177, -), |
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RNA editing positional annotations for PLSCR1 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_1030595 | chr3_146519255_- | intronic |
| ADediting_1030596 | chr3_146519314_- | intronic |
| ADediting_1030597 | chr3_146519333_- | intronic |
| ADediting_1030598 | chr3_146519697_- | intronic |
| ADediting_1030599 | chr3_146519732_- | intronic |
| ADediting_1030600 | chr3_146519742_- | intronic |
| ADediting_1030601 | chr3_146519780_- | intronic |
| ADediting_1030602 | chr3_146526043_- | intronic |
| ADediting_1030603 | chr3_146526998_- | intronic |
| ADediting_1030604 | chr3_146529543_- | intronic |
| ADediting_1030605 | chr3_146529610_- | intronic |
| ADediting_1030606 | chr3_146529637_- | intronic |
| ADediting_1030607 | chr3_146529641_- | intronic |
| ADediting_1030608 | chr3_146529651_- | intronic |
| ADediting_1030609 | chr3_146529719_- | intronic |
| ADediting_1030610 | chr3_146542248_- | intronic |
| ADediting_1030611 | chr3_146542252_- | intronic |
| ADediting_1030612 | chr3_146542259_- | intronic |
| ADediting_1030613 | chr3_146542266_- | intronic |
| ADediting_1030614 | chr3_146542270_- | intronic |
| ADediting_1030615 | chr3_146542306_- | intronic |
| ADediting_1030616 | chr3_146542333_- | intronic |
| ADediting_1030617 | chr3_146543056_- | intronic |
| ADediting_1030618 | chr3_146543061_- | intronic |
| ADediting_1030619 | chr3_146543063_- | intronic |
| ADediting_1030620 | chr3_146543098_- | intronic |
| ADediting_1030621 | chr3_146543102_- | intronic |
| ADediting_1030622 | chr3_146543112_- | intronic |
| ADediting_1030623 | chr3_146543116_- | intronic |
| ADediting_1030624 | chr3_146543151_- | intronic |
| ADediting_1030625 | chr3_146543157_- | intronic |
| ADediting_1030626 | chr3_146543176_- | intronic |
| ADediting_1572516 | chr3_146519694_- | intronic |
| ADediting_1572517 | chr3_146542346_- | intronic |
| ADediting_1644929 | chr3_146519740_- | intronic |
| ADediting_1644930 | chr3_146526010_- | intronic |
| ADediting_1644931 | chr3_146526055_- | intronic |
| ADediting_1644932 | chr3_146526071_- | intronic |
| ADediting_1644933 | chr3_146542293_- | intronic |
| ADediting_1644934 | chr3_146542313_- | intronic |
| ADediting_1644935 | chr3_146543074_- | intronic |
| ADediting_1644936 | chr3_146543120_- | intronic |
| ADediting_1644937 | chr3_146543125_- | intronic |
| ADediting_1644938 | chr3_146543134_- | intronic |
| ADediting_1644939 | chr3_146543177_- | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_1030602 | chr3_146526043_- | SINE | Alu | Name=AluSc8 |
| ADediting_1030603 | chr3_146526998_- | SINE | Alu | Name=AluSx4 |
| ADediting_1030604 | chr3_146529543_- | SINE | Alu | Name=AluY |
| ADediting_1030605 | chr3_146529610_- | SINE | Alu | Name=AluY |
| ADediting_1030606 | chr3_146529637_- | SINE | Alu | Name=AluY |
| ADediting_1030607 | chr3_146529641_- | SINE | Alu | Name=AluY |
| ADediting_1030608 | chr3_146529651_- | SINE | Alu | Name=AluY |
| ADediting_1030609 | chr3_146529719_- | SINE | Alu | Name=AluY |
| ADediting_1030610 | chr3_146542248_- | LINE | L2 | Name=L2b |
| ADediting_1030611 | chr3_146542252_- | LINE | L2 | Name=L2b |
| ADediting_1030612 | chr3_146542259_- | LINE | L2 | Name=L2b |
| ADediting_1030613 | chr3_146542266_- | LINE | L2 | Name=L2b |
| ADediting_1030614 | chr3_146542270_- | LINE | L2 | Name=L2b |
| ADediting_1030617 | chr3_146543056_- | LINE | L2 | Name=L2b |
| ADediting_1030618 | chr3_146543061_- | LINE | L2 | Name=L2b |
| ADediting_1030619 | chr3_146543063_- | LINE | L2 | Name=L2b |
| ADediting_1030620 | chr3_146543098_- | LINE | L2 | Name=L2b |
| ADediting_1030621 | chr3_146543102_- | LINE | L2 | Name=L2b |
| ADediting_1030622 | chr3_146543112_- | LINE | L2 | Name=L2b |
| ADediting_1030623 | chr3_146543116_- | LINE | L2 | Name=L2b |
| ADediting_1030624 | chr3_146543151_- | LINE | L2 | Name=L2b |
| ADediting_1030625 | chr3_146543157_- | LINE | L2 | Name=L2b |
| ADediting_1030626 | chr3_146543176_- | LINE | L2 | Name=L2b |
| ADediting_1644930 | chr3_146526010_- | SINE | Alu | Name=AluSc8 |
| ADediting_1644931 | chr3_146526055_- | SINE | Alu | Name=AluSc8 |
| ADediting_1644932 | chr3_146526071_- | SINE | Alu | Name=AluSc8 |
| ADediting_1644933 | chr3_146542293_- | LINE | L2 | Name=L2b |
| ADediting_1644935 | chr3_146543074_- | LINE | L2 | Name=L2b |
| ADediting_1644936 | chr3_146543120_- | LINE | L2 | Name=L2b |
| ADediting_1644937 | chr3_146543125_- | LINE | L2 | Name=L2b |
| ADediting_1644938 | chr3_146543134_- | LINE | L2 | Name=L2b |
| ADediting_1644939 | chr3_146543177_- | LINE | L2 | Name=L2b |
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RNA A-to-I editing events in the alternative splicing sites for PLSCR1 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for PLSCR1 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for PLSCR1 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for PLSCR1 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000188313.13 | ENST00000342435.9 | PLSCR1-201 | hsa-miR-381-3p | chr3 | 146515899 | 146515905 | 7mer-1a | 146515899 | 146515921 | 141 | -15 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000188313.13 | ENST00000342435.9 | PLSCR1-201 | hsa-miR-381-3p | chr3 | 146515971 | 146515977 | 7mer-m8 | 146515970 | 146515991 | 144 | -13.11 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000188313.13 | ENST00000448787.6 | PLSCR1-202 | hsa-miR-381-3p | chr3 | 146515971 | 146515977 | 7mer-m8 | 146515970 | 146515991 | 144 | -13.11 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000188313.13 | ENST00000487389.5 | PLSCR1-214 | hsa-miR-381-3p | chr3 | 146515899 | 146515905 | 7mer-1a | 146515899 | 146515921 | 141 | -15 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000188313.13 | ENST00000487389.5 | PLSCR1-214 | hsa-miR-381-3p | chr3 | 146515971 | 146515977 | 7mer-m8 | 146515970 | 146515991 | 144 | -13.11 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for PLSCR1 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for PLSCR1 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 1.42328629219124e-09 | 0.335138602414819 | 0.00949677347927223 | 0.147100528524276 | 0.163054161578218 | 0.0794191051768244 |
| AC | 3.32666567056409e-49 | 0.764528292289228 | 5.54913803068813e-22 | 0.559364323864096 | 8.2305235756997e-13 | 0.432381813515788 |
| CER | 6.36609565306412e-06 | 0.35918400452871 | 0.0278103617056991 | 0.179663986112925 | 0.018719582112566 | 0.191782842021068 |
| TCX | 9.02690930923185e-05 | 0.314182466304897 | 0.397830596507129 | -0.0695330221600609 | 0.000540245642665946 | 0.279201205332716 |
| FP | 2.19561632888326e-06 | 0.346267268763287 | 0.0370792550860206 | 0.156407990264125 | 0.381905809364169 | 0.0659314728619853 |
| PG | 1.829684653559e-20 | 0.611569903729122 | 1.28320020120764e-10 | 0.449083595610746 | 0.663867739080176 | 0.0320729218277314 |
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Relation with AD stages for PLSCR1 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| TCX | 1.80646968601675e-07 | 0.480940611223436 |
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RelatedDrugs for PLSCR1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PLSCR1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| PLSCR1 | C0021400 | Influenza | 1 | CTD_human |
| PLSCR1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
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