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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for PHKG1 |
 Gene summary |
| Gene information | Gene symbol | PHKG1 | Gene ID | 5260 |
| Gene name | phosphorylase kinase catalytic subunit gamma 1 | |
| Synonyms | PHKG | |
| Cytomap | 7p11.2 | |
| Type of gene | protein-coding | |
| Description | phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoformPHK-gamma-Mphosphorylase b kinase gamma catalytic chain, skeletal muscle isoformphosphorylase kinase gamma subunit 1phosphorylase kinase subunit gamma-1phosphorylase kinase, g | |
| Modification date | 20200313 | |
| UniProtAcc | Q16816, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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RNA A-to-I events for PHKG1 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_1340479(56082851, -), ADediting_1340480(56082863, -), ADediting_1340481(56084401, -), ADediting_1340482(56084511, -), ADediting_1340483(56084512, -), ADediting_1340484(56084525, -), ADediting_1340485(56084567, -), ADediting_1340486(56084593, -), ADediting_1340487(56084646, -), ADediting_1340488(56085049, -), ADediting_1340489(56085085, -), ADediting_1340490(56085192, -), ADediting_1340491(56085207, -), ADediting_1340492(56085233, -), ADediting_1340493(56085234, -), ADediting_1340494(56085298, -), ADediting_1340495(56085325, -), ADediting_1340496(56085377, -), ADediting_1340497(56085387, -), ADediting_1340498(56085708, -), ADediting_1340499(56085720, -), ADediting_1340500(56085747, -), ADediting_1340501(56085773, -), ADediting_1340502(56085793, -), ADediting_1340503(56085799, -), ADediting_1340504(56085852, -), ADediting_1340505(56085862, -), ADediting_1340506(56085891, -), ADediting_1340507(56085911, -), ADediting_1340508(56085938, -), ADediting_1340509(56085969, -), ADediting_1340510(56085992, -), ADediting_1340511(56086414, -), ADediting_1340512(56086416, -), ADediting_1340513(56088102, -), ADediting_1340514(56088145, -), ADediting_1340515(56088173, -), ADediting_1340516(56088179, -), ADediting_1340517(56088295, -), ADediting_1340518(56088413, -), ADediting_1340519(56088416, -), ADediting_1340520(56088430, -), ADediting_1340521(56088442, -), ADediting_1340522(56088449, -), ADediting_1340523(56088465, -), ADediting_1340524(56088468, -), ADediting_1340525(56088489, -), ADediting_1340526(56088519, -), ADediting_1340527(56088629, -), ADediting_1340528(56088630, -), ADediting_1340529(56088636, -), ADediting_1340530(56088645, -), ADediting_1340531(56089148, -), ADediting_1340532(56089159, -), ADediting_1340533(56089169, -), ADediting_1340534(56089186, -), ADediting_1340535(56089212, -), ADediting_1340536(56089224, -), ADediting_1340537(56089231, -), ADediting_1340538(56089238, -), ADediting_1340539(56089275, -), ADediting_1340540(56089525, -), ADediting_1340541(56089620, -), ADediting_1340542(56089621, -), ADediting_1340543(56089661, -), ADediting_1340544(56089662, -), ADediting_1340545(56089684, -), ADediting_1340546(56089740, -), ADediting_1340547(56089860, -), ADediting_1340548(56089903, -), ADediting_1340549(56090183, -), ADediting_1340550(56090184, -), ADediting_1340551(56090187, -), ADediting_1340552(56090212, -), ADediting_1340553(56090253, -), ADediting_1340554(56090254, -), ADediting_1340555(56090276, -), ADediting_1340556(56090295, -), ADediting_1340557(56090298, -), ADediting_1340558(56090366, -), ADediting_1340559(56090367, -), ADediting_1340560(56090967, -), ADediting_1340561(56090994, -), ADediting_1340562(56091020, -), ADediting_1340563(56091025, -), ADediting_1340564(56091106, -), ADediting_1340565(56091114, -), ADediting_1340566(56091131, -), ADediting_1340567(56091503, -), ADediting_1340568(56092411, -), ADediting_1340569(56092548, -), ADediting_1587896(56082864, -), ADediting_1587897(56082923, -), ADediting_1587898(56082940, -), ADediting_1587899(56083037, -), ADediting_1587900(56084446, -), ADediting_1587901(56085311, -), ADediting_1587902(56086443, -), |
Top |
RNA editing positional annotations for PHKG1 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_1340479 | chr7_56082851_- | intronic |
| ADediting_1340480 | chr7_56082863_- | intronic |
| ADediting_1340481 | chr7_56084401_- | intronic |
| ADediting_1340482 | chr7_56084511_- | intronic |
| ADediting_1340483 | chr7_56084512_- | intronic |
| ADediting_1340484 | chr7_56084525_- | intronic |
| ADediting_1340485 | chr7_56084567_- | intronic |
| ADediting_1340486 | chr7_56084593_- | intronic |
| ADediting_1340487 | chr7_56084646_- | intronic |
| ADediting_1340488 | chr7_56085049_- | intronic |
| ADediting_1340489 | chr7_56085085_- | intronic |
| ADediting_1340490 | chr7_56085192_- | intronic |
| ADediting_1340491 | chr7_56085207_- | intronic |
| ADediting_1340492 | chr7_56085233_- | intronic |
| ADediting_1340493 | chr7_56085234_- | intronic |
| ADediting_1340494 | chr7_56085298_- | intronic |
| ADediting_1340495 | chr7_56085325_- | intronic |
| ADediting_1340496 | chr7_56085377_- | intronic |
| ADediting_1340497 | chr7_56085387_- | intronic |
| ADediting_1340498 | chr7_56085708_- | intronic |
| ADediting_1340499 | chr7_56085720_- | intronic |
| ADediting_1340500 | chr7_56085747_- | intronic |
| ADediting_1340501 | chr7_56085773_- | intronic |
| ADediting_1340502 | chr7_56085793_- | intronic |
| ADediting_1340503 | chr7_56085799_- | intronic |
| ADediting_1340504 | chr7_56085852_- | intronic |
| ADediting_1340505 | chr7_56085862_- | intronic |
| ADediting_1340506 | chr7_56085891_- | intronic |
| ADediting_1340507 | chr7_56085911_- | intronic |
| ADediting_1340508 | chr7_56085938_- | intronic |
| ADediting_1340509 | chr7_56085969_- | intronic |
| ADediting_1340510 | chr7_56085992_- | intronic |
| ADediting_1340511 | chr7_56086414_- | intronic |
| ADediting_1340512 | chr7_56086416_- | intronic |
| ADediting_1340513 | chr7_56088102_- | intronic |
| ADediting_1340514 | chr7_56088145_- | intronic |
| ADediting_1340515 | chr7_56088173_- | intronic |
| ADediting_1340516 | chr7_56088179_- | intronic |
| ADediting_1340517 | chr7_56088295_- | intronic |
| ADediting_1340518 | chr7_56088413_- | intronic |
| ADediting_1340519 | chr7_56088416_- | intronic |
| ADediting_1340520 | chr7_56088430_- | intronic |
| ADediting_1340521 | chr7_56088442_- | intronic |
| ADediting_1340522 | chr7_56088449_- | intronic |
| ADediting_1340523 | chr7_56088465_- | intronic |
| ADediting_1340524 | chr7_56088468_- | intronic |
| ADediting_1340525 | chr7_56088489_- | intronic |
| ADediting_1340526 | chr7_56088519_- | intronic |
| ADediting_1340527 | chr7_56088629_- | intronic |
| ADediting_1340528 | chr7_56088630_- | intronic |
| ADediting_1340529 | chr7_56088636_- | intronic |
| ADediting_1340530 | chr7_56088645_- | intronic |
| ADediting_1340531 | chr7_56089148_- | intronic |
| ADediting_1340532 | chr7_56089159_- | intronic |
| ADediting_1340533 | chr7_56089169_- | intronic |
| ADediting_1340534 | chr7_56089186_- | intronic |
| ADediting_1340535 | chr7_56089212_- | intronic |
| ADediting_1340536 | chr7_56089224_- | intronic |
| ADediting_1340537 | chr7_56089231_- | intronic |
| ADediting_1340538 | chr7_56089238_- | intronic |
| ADediting_1340539 | chr7_56089275_- | intronic |
| ADediting_1340540 | chr7_56089525_- | intronic |
| ADediting_1340541 | chr7_56089620_- | intronic |
| ADediting_1340542 | chr7_56089621_- | intronic |
| ADediting_1340543 | chr7_56089661_- | intronic |
| ADediting_1340544 | chr7_56089662_- | intronic |
| ADediting_1340545 | chr7_56089684_- | intronic |
| ADediting_1340546 | chr7_56089740_- | intronic |
| ADediting_1340547 | chr7_56089860_- | intronic |
| ADediting_1340548 | chr7_56089903_- | intronic |
| ADediting_1340549 | chr7_56090183_- | intronic |
| ADediting_1340550 | chr7_56090184_- | intronic |
| ADediting_1340551 | chr7_56090187_- | intronic |
| ADediting_1340552 | chr7_56090212_- | intronic |
| ADediting_1340553 | chr7_56090253_- | intronic |
| ADediting_1340554 | chr7_56090254_- | intronic |
| ADediting_1340555 | chr7_56090276_- | intronic |
| ADediting_1340556 | chr7_56090295_- | intronic |
| ADediting_1340557 | chr7_56090298_- | intronic |
| ADediting_1340558 | chr7_56090366_- | intronic |
| ADediting_1340559 | chr7_56090367_- | intronic |
| ADediting_1340560 | chr7_56090967_- | intronic |
| ADediting_1340561 | chr7_56090994_- | intronic |
| ADediting_1340562 | chr7_56091020_- | intronic |
| ADediting_1340563 | chr7_56091025_- | intronic |
| ADediting_1340564 | chr7_56091106_- | intronic |
| ADediting_1340565 | chr7_56091114_- | intronic |
| ADediting_1340566 | chr7_56091131_- | intronic |
| ADediting_1340567 | chr7_56091503_- | intronic |
| ADediting_1340568 | chr7_56092411_- | intronic |
| ADediting_1340569 | chr7_56092548_- | intronic |
| ADediting_1587896 | chr7_56082864_- | intronic |
| ADediting_1587897 | chr7_56082923_- | intronic |
| ADediting_1587898 | chr7_56082940_- | intronic |
| ADediting_1587899 | chr7_56083037_- | intronic |
| ADediting_1587900 | chr7_56084446_- | intronic |
| ADediting_1587901 | chr7_56085311_- | intronic |
| ADediting_1587902 | chr7_56086443_- | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_1340479 | chr7_56082851_- | SINE | Alu | Name=AluSg |
| ADediting_1340480 | chr7_56082863_- | SINE | Alu | Name=AluSg |
| ADediting_1340481 | chr7_56084401_- | SINE | Alu | Name=AluSq2 |
| ADediting_1340482 | chr7_56084511_- | SINE | Alu | Name=AluSq2 |
| ADediting_1340483 | chr7_56084512_- | SINE | Alu | Name=AluSq2 |
| ADediting_1340484 | chr7_56084525_- | SINE | Alu | Name=AluSq2 |
| ADediting_1340485 | chr7_56084567_- | SINE | Alu | Name=AluSq2 |
| ADediting_1340486 | chr7_56084593_- | SINE | Alu | Name=AluSq2 |
| ADediting_1340487 | chr7_56084646_- | SINE | Alu | Name=AluSq2 |
| ADediting_1340488 | chr7_56085049_- | SINE | Alu | Name=AluSz6 |
| ADediting_1340489 | chr7_56085085_- | SINE | Alu | Name=AluSz6 |
| ADediting_1340490 | chr7_56085192_- | SINE | Alu | Name=AluSz6 |
| ADediting_1340491 | chr7_56085207_- | SINE | Alu | Name=AluSz6 |
| ADediting_1340492 | chr7_56085233_- | SINE | Alu | Name=AluSz6 |
| ADediting_1340493 | chr7_56085234_- | SINE | Alu | Name=AluSz6 |
| ADediting_1340494 | chr7_56085298_- | SINE | Alu | Name=AluJr |
| ADediting_1340495 | chr7_56085325_- | SINE | Alu | Name=AluJr |
| ADediting_1340496 | chr7_56085377_- | SINE | Alu | Name=AluJr |
| ADediting_1340497 | chr7_56085387_- | SINE | Alu | Name=AluJr |
| ADediting_1340498 | chr7_56085708_- | SINE | Alu | Name=AluSq2 |
| ADediting_1340499 | chr7_56085720_- | SINE | Alu | Name=AluSq2 |
| ADediting_1340500 | chr7_56085747_- | SINE | Alu | Name=AluSq2 |
| ADediting_1340501 | chr7_56085773_- | SINE | Alu | Name=AluSq2 |
| ADediting_1340502 | chr7_56085793_- | SINE | Alu | Name=AluSq2 |
| ADediting_1340503 | chr7_56085799_- | SINE | Alu | Name=AluSq2 |
| ADediting_1340504 | chr7_56085852_- | SINE | Alu | Name=AluSq2 |
| ADediting_1340505 | chr7_56085862_- | SINE | Alu | Name=AluSq2 |
| ADediting_1340506 | chr7_56085891_- | SINE | Alu | Name=AluSq2 |
| ADediting_1340507 | chr7_56085911_- | SINE | Alu | Name=AluSq2 |
| ADediting_1340508 | chr7_56085938_- | SINE | Alu | Name=AluSq2 |
| ADediting_1340509 | chr7_56085969_- | SINE | Alu | Name=AluSq2 |
| ADediting_1340510 | chr7_56085992_- | SINE | Alu | Name=AluSq2 |
| ADediting_1340511 | chr7_56086414_- | SINE | Alu | Name=AluJb |
| ADediting_1340512 | chr7_56086416_- | SINE | Alu | Name=AluJb |
| ADediting_1340513 | chr7_56088102_- | SINE | Alu | Name=AluSx1 |
| ADediting_1340514 | chr7_56088145_- | SINE | Alu | Name=AluSx1 |
| ADediting_1340515 | chr7_56088173_- | SINE | Alu | Name=AluSx1 |
| ADediting_1340516 | chr7_56088179_- | SINE | Alu | Name=AluSx1 |
| ADediting_1340517 | chr7_56088295_- | SINE | Alu | Name=AluSx1 |
| ADediting_1340518 | chr7_56088413_- | SINE | Alu | Name=AluJb |
| ADediting_1340519 | chr7_56088416_- | SINE | Alu | Name=AluJb |
| ADediting_1340520 | chr7_56088430_- | SINE | Alu | Name=AluJb |
| ADediting_1340521 | chr7_56088442_- | SINE | Alu | Name=AluJb |
| ADediting_1340522 | chr7_56088449_- | SINE | Alu | Name=AluJb |
| ADediting_1340523 | chr7_56088465_- | SINE | Alu | Name=AluJb |
| ADediting_1340524 | chr7_56088468_- | SINE | Alu | Name=AluJb |
| ADediting_1340525 | chr7_56088489_- | SINE | Alu | Name=AluJb |
| ADediting_1340526 | chr7_56088519_- | SINE | Alu | Name=AluJb |
| ADediting_1340527 | chr7_56088629_- | SINE | Alu | Name=AluJr |
| ADediting_1340528 | chr7_56088630_- | SINE | Alu | Name=AluJr |
| ADediting_1340529 | chr7_56088636_- | SINE | Alu | Name=AluJr |
| ADediting_1340530 | chr7_56088645_- | SINE | Alu | Name=AluJr |
| ADediting_1340531 | chr7_56089148_- | SINE | Alu | Name=AluSz |
| ADediting_1340532 | chr7_56089159_- | SINE | Alu | Name=AluSz |
| ADediting_1340533 | chr7_56089169_- | SINE | Alu | Name=AluSz |
| ADediting_1340534 | chr7_56089186_- | SINE | Alu | Name=AluSz |
| ADediting_1340535 | chr7_56089212_- | SINE | Alu | Name=AluSz |
| ADediting_1340536 | chr7_56089224_- | SINE | Alu | Name=AluSz |
| ADediting_1340537 | chr7_56089231_- | SINE | Alu | Name=AluSz |
| ADediting_1340538 | chr7_56089238_- | SINE | Alu | Name=AluSz |
| ADediting_1340539 | chr7_56089275_- | SINE | Alu | Name=AluSz |
| ADediting_1340540 | chr7_56089525_- | SINE | Alu | Name=AluJr |
| ADediting_1340541 | chr7_56089620_- | SINE | Alu | Name=AluSx1 |
| ADediting_1340542 | chr7_56089621_- | SINE | Alu | Name=AluSx1 |
| ADediting_1340543 | chr7_56089661_- | SINE | Alu | Name=AluSx1 |
| ADediting_1340544 | chr7_56089662_- | SINE | Alu | Name=AluSx1 |
| ADediting_1340545 | chr7_56089684_- | SINE | Alu | Name=AluSx1 |
| ADediting_1340546 | chr7_56089740_- | SINE | Alu | Name=AluSx1 |
| ADediting_1340547 | chr7_56089860_- | SINE | Alu | Name=AluJr |
| ADediting_1340548 | chr7_56089903_- | SINE | Alu | Name=AluJr |
| ADediting_1340549 | chr7_56090183_- | SINE | Alu | Name=AluSz |
| ADediting_1340550 | chr7_56090184_- | SINE | Alu | Name=AluSz |
| ADediting_1340551 | chr7_56090187_- | SINE | Alu | Name=AluSz |
| ADediting_1340552 | chr7_56090212_- | SINE | Alu | Name=AluSz |
| ADediting_1340553 | chr7_56090253_- | SINE | Alu | Name=AluSz |
| ADediting_1340554 | chr7_56090254_- | SINE | Alu | Name=AluSz |
| ADediting_1340555 | chr7_56090276_- | SINE | Alu | Name=AluSz |
| ADediting_1340556 | chr7_56090295_- | SINE | Alu | Name=AluSz |
| ADediting_1340557 | chr7_56090298_- | SINE | Alu | Name=AluSz |
| ADediting_1340558 | chr7_56090366_- | SINE | Alu | Name=AluSz |
| ADediting_1340559 | chr7_56090367_- | SINE | Alu | Name=AluSz |
| ADediting_1340560 | chr7_56090967_- | SINE | Alu | Name=AluSz |
| ADediting_1340561 | chr7_56090994_- | SINE | Alu | Name=AluSz |
| ADediting_1340562 | chr7_56091020_- | SINE | Alu | Name=AluSz |
| ADediting_1340563 | chr7_56091025_- | SINE | Alu | Name=AluSz |
| ADediting_1340564 | chr7_56091106_- | SINE | Alu | Name=AluSz |
| ADediting_1340565 | chr7_56091114_- | SINE | Alu | Name=AluSz |
| ADediting_1340566 | chr7_56091131_- | SINE | Alu | Name=AluSz |
| ADediting_1340567 | chr7_56091503_- | SINE | Alu | Name=AluY |
| ADediting_1340568 | chr7_56092411_- | SINE | Alu | Name=AluSz |
| ADediting_1340569 | chr7_56092548_- | SINE | Alu | Name=AluSz |
| ADediting_1587896 | chr7_56082864_- | SINE | Alu | Name=AluSg |
| ADediting_1587897 | chr7_56082923_- | SINE | Alu | Name=AluSg |
| ADediting_1587898 | chr7_56082940_- | SINE | Alu | Name=AluSg |
| ADediting_1587899 | chr7_56083037_- | SINE | Alu | Name=AluSg |
| ADediting_1587900 | chr7_56084446_- | SINE | Alu | Name=AluSq2 |
| ADediting_1587901 | chr7_56085311_- | SINE | Alu | Name=AluJr |
| ADediting_1587902 | chr7_56086443_- | SINE | Alu | Name=AluJb |
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RNA A-to-I editing events in the alternative splicing sites for PHKG1 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| ES | ADediting_1587898 | chr7_56082940_- | 56082930:56082952 | 3ss | 8i | TGTATTTTTAGTAGAGACAGGGT | -13.20 | TGTATTTTTAGTGGAGACAGGGT | -7.65 |
| ES | ADediting_1587898 | chr7_56082940_- | 56082939:56082961 | 3ss | 2e | GCTAATTTTTGTATTTTTAGTAG | 3.60 | GCTAATTTTTGTATTTTTAGTGG | 4.93 |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for PHKG1 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for PHKG1 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for PHKG1 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_496066 | chr15_66496985_- | ENSG00000164776.9 | ENST00000452681.6 | PHKG1-205 | hsa-miR-4512 | chr7 | 56080835 | 56080841 | 7mer-m8 | 56080834 | 56080856 | 142 | -23.74 |
| ADediting_496066 | chr15_66496985_- | ENSG00000164776.9 | ENST00000537360.5 | PHKG1-210 | hsa-miR-4512 | chr7 | 56080835 | 56080841 | 7mer-m8 | 56080834 | 56080856 | 142 | -23.74 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for PHKG1 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for PHKG1 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| CER | ADediting_1340488 | chr7_56085049_- | 0.00255712291295414 | 0.244590053066242 | 4.02234142221269e-07 | 0.399751089046078 | 0.0899104809569152 | 0.138957058611323 |
| DLPFC | ADediting_1340503 | chr7_56085799_- | 0.0437081373295747 | 0.114636238141516 | 0.722610008689698 | -0.0202407994711148 | 4.13913590957459e-14 | 0.411666760936167 |
| DLPFC | ADediting_1340520 | chr7_56088430_- | 0.0845372245817589 | 0.0981301836362163 | 0.539976338580495 | 0.034937983707852 | 9.33301033090587e-11 | 0.35713047282757 |
| DLPFC | ADediting_1340521 | chr7_56088442_- | 0.50474023559214 | 0.0380258009726489 | 0.740188864619502 | -0.0189085008506232 | 4.19245928596087e-08 | 0.305161743011925 |
| DLPFC | ADediting_1340522 | chr7_56088449_- | 0.44447535521947 | 0.0435850742617696 | 0.715244847026677 | -0.0208022478540288 | 2.71882157675884e-09 | 0.329651140528465 |
| DLPFC | ADediting_1340523 | chr7_56088465_- | 0.706586130507904 | 0.0214648860049485 | 0.560114840067086 | -0.0332185457221678 | 7.23793506992556e-10 | 0.34075878050246 |
| DLPFC | ADediting_1340525 | chr7_56088489_- | 0.277798298325699 | 0.0618304665720361 | 0.725544919169756 | -0.0200176165283946 | 5.38852095395474e-10 | 0.34317627709778 |
| DLPFC | ADediting_1340534 | chr7_56089186_- | 0.0965226954488257 | 0.0945628303777043 | 0.680154584054871 | -0.0235060745071232 | 8.32897650546489e-21 | 0.497692726624033 |
| DLPFC | ADediting_1340543 | chr7_56089661_- | 0.358337294002486 | 0.0523451379451738 | 0.498647408410094 | -0.0385709190503781 | 3.06014631123734e-08 | 0.308095563330226 |
| CER | ADediting_1587901 | chr7_56085311_- | 0.00053303974805012 | 0.279481151025308 | 4.95909264716608e-05 | 0.324977860385633 | 0.205752643507537 | 0.103903176151233 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 1.68585127611595e-05 | 0.241730302186332 | 0.0030062361417998 | 0.167999276894784 | 1.11568306532771e-20 | 0.496268482656175 |
| AC | 2.59244776056521e-38 | 0.701225514310028 | 2.91195291906218e-15 | 0.471810810307926 | 3.94388060414416e-28 | 0.621700973565517 |
| PCC | 0.000185990012273741 | 0.267242364782273 | 0.0561405067524496 | 0.138441210346701 | 4.25158539632298e-09 | 0.408983002763975 |
| CER | 0.000160586738472217 | 0.303396166756816 | 0.000991889372977836 | 0.266215762700927 | 9.49040189046119e-15 | 0.578076238766745 |
| TCX | 0.0393701564161957 | 0.168427794506249 | 0.223408822559 | -0.0999967237554584 | 2.5190367264568e-08 | 0.435658319500165 |
| FP | 1.06572274386943e-05 | 0.323412817180325 | 0.00106013887757623 | 0.243414451527994 | 1.81426891732805e-08 | 0.406410079476035 |
| IFG | 0.236424771284265 | 0.245722125069074 | 0.207648636736336 | 0.260977739921244 | 0.00238751093425733 | 0.579718032173328 |
| PG | 0.35620600181965 | 0.0680298756166978 | 0.468122413354257 | -0.0535216421972178 | 1.1819459145923e-10 | 0.449860792357186 |
| STG | 0.346512265394332 | 0.103991896477946 | 0.779415886115113 | 0.0310166648371668 | 2.6811848865115e-06 | 0.486664782461479 |
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Relation with AD stages for PHKG1 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| CER | ADediting_1340488 | chr7_56085049_- | 0.000225347607514273 | 0.347847507773665 |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 0.0005272348502347 | 0.328100533870172 |
| TCX | 4.50478524186646e-05 | 0.38542521947113 |
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RelatedDrugs for PHKG1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| PHKG1 | Q16816 | DB12010 | Fostamatinib | Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform | small molecule | approved|investigational |
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RelatedDiseases for PHKG1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| PHKG1 | C1319315 | Adenocarcinoma of large intestine | 1 | UNIPROT |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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