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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited versus non-edited samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with AD stages

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene


Gene summary for PGGT1B

check button Gene summary
Gene informationGene symbol

PGGT1B

Gene ID

5229

Gene nameprotein geranylgeranyltransferase type I subunit beta
SynonymsBGGI|GGTI
Cytomap

5q22.3

Type of geneprotein-coding
Descriptiongeranylgeranyl transferase type-1 subunit betaCTC-428G20.3GGTase-I-betageranylgeranyl transferase type I subunit betageranylgeranyltransferase type I beta subunitprotein geranylgeranyltransferase type I, beta subunittype I protein geranyl-geranyltra
Modification date20200313
UniProtAcc

P53609,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
PGGT1B

GO:0018344

protein geranylgeranylation

16893176


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RNA A-to-I events for PGGT1B

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_1159653(115205821, -), ADediting_1159654(115205822, -), ADediting_1159655(115205823, -), ADediting_1159656(115205824, -), ADediting_1159657(115205836, -), ADediting_1159658(115205840, -), ADediting_1159659(115205841, -), ADediting_1159660(115205843, -), ADediting_1159661(115205845, -), ADediting_1159662(115205847, -), ADediting_1159663(115205851, -), ADediting_1159664(115205852, -), ADediting_1159665(115205869, -), ADediting_1159666(115205876, -), ADediting_1159667(115205877, -), ADediting_1159668(115205879, -), ADediting_1159669(115205883, -), ADediting_1159670(115205884, -), ADediting_1159671(115205885, -), ADediting_1159672(115205886, -), ADediting_1159673(115205895, -), ADediting_1159674(115205904, -), ADediting_1159675(115205906, -), ADediting_1159676(115205907, -), ADediting_1159677(115205908, -), ADediting_1159678(115205909, -), ADediting_1159679(115205912, -), ADediting_1159680(115205915, -), ADediting_1159681(115205916, -), ADediting_1159682(115205918, -), ADediting_1159683(115205925, -), ADediting_1159684(115205967, -), ADediting_1159685(115206004, -), ADediting_1159686(115206005, -), ADediting_1159687(115206017, -), ADediting_1159688(115206020, -), ADediting_1159689(115206031, -), ADediting_1159690(115206036, -), ADediting_1159691(115206038, -), ADediting_1159692(115206042, -), ADediting_1159693(115206044, -), ADediting_1159694(115206058, -), ADediting_1159695(115206616, -), ADediting_1159696(115206621, -), ADediting_1159697(115206627, -), ADediting_1159698(115206632, -), ADediting_1159699(115206635, -), ADediting_1159700(115206637, -), ADediting_1159701(115206642, -), ADediting_1159702(115206647, -), ADediting_1159703(115206651, -), ADediting_1159704(115206667, -), ADediting_1159705(115206668, -), ADediting_1159706(115206672, -), ADediting_1159707(115206680, -), ADediting_1159708(115206681, -), ADediting_1159709(115206689, -), ADediting_1159710(115206691, -), ADediting_1159711(115206695, -), ADediting_1159712(115206697, -), ADediting_1159713(115206702, -), ADediting_1159714(115206705, -), ADediting_1159715(115206706, -), ADediting_1159716(115206712, -), ADediting_1159717(115206714, -), ADediting_1159718(115206716, -), ADediting_1159719(115206719, -), ADediting_1159720(115206720, -), ADediting_1159721(115206724, -), ADediting_1159722(115206726, -), ADediting_1159723(115206727, -), ADediting_1159724(115206728, -), ADediting_1159725(115206734, -), ADediting_1159726(115206735, -), ADediting_1159727(115206736, -), ADediting_1159728(115206738, -), ADediting_1159729(115206739, -), ADediting_1159730(115206740, -), ADediting_1159731(115206745, -), ADediting_1159732(115206751, -), ADediting_1159733(115206753, -), ADediting_1159734(115206757, -), ADediting_1159735(115206764, -), ADediting_1159736(115206768, -), ADediting_1159737(115206780, -), ADediting_1159738(115206782, -), ADediting_1159739(115206789, -), ADediting_1159740(115206790, -), ADediting_1159741(115206791, -), ADediting_1159742(115244209, -), ADediting_1159743(115244276, -), ADediting_1159744(115244365, -), ADediting_1159745(115244402, -), ADediting_1159746(115244459, -), ADediting_1159747(115244654, -), ADediting_1159748(115244742, -), ADediting_1159749(115244770, -), ADediting_1159750(115244773, -), ADediting_1159751(115244794, -), ADediting_1159752(115244795, -), ADediting_1159753(115244804, -), ADediting_1159754(115244814, -), ADediting_1159755(115244818, -), ADediting_1159756(115244833, -), ADediting_1159757(115244837, -), ADediting_1159758(115244842, -), ADediting_1159759(115244863, -), ADediting_1159760(115244864, -), ADediting_1578742(115205853, -), ADediting_1578743(115205893, -), ADediting_1578744(115205910, -), ADediting_1578745(115238358, -),

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RNA editing positional annotations for PGGT1B using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_1159653chr5_115205821_-UTR3
ADediting_1159654chr5_115205822_-UTR3
ADediting_1159655chr5_115205823_-UTR3
ADediting_1159656chr5_115205824_-UTR3
ADediting_1159657chr5_115205836_-UTR3
ADediting_1159658chr5_115205840_-UTR3
ADediting_1159659chr5_115205841_-UTR3
ADediting_1159660chr5_115205843_-UTR3
ADediting_1159661chr5_115205845_-UTR3
ADediting_1159662chr5_115205847_-UTR3
ADediting_1159663chr5_115205851_-UTR3
ADediting_1159664chr5_115205852_-UTR3
ADediting_1159665chr5_115205869_-UTR3
ADediting_1159666chr5_115205876_-UTR3
ADediting_1159667chr5_115205877_-UTR3
ADediting_1159668chr5_115205879_-UTR3
ADediting_1159669chr5_115205883_-UTR3
ADediting_1159670chr5_115205884_-UTR3
ADediting_1159671chr5_115205885_-UTR3
ADediting_1159672chr5_115205886_-UTR3
ADediting_1159673chr5_115205895_-UTR3
ADediting_1159674chr5_115205904_-UTR3
ADediting_1159675chr5_115205906_-UTR3
ADediting_1159676chr5_115205907_-UTR3
ADediting_1159677chr5_115205908_-UTR3
ADediting_1159678chr5_115205909_-UTR3
ADediting_1159679chr5_115205912_-UTR3
ADediting_1159680chr5_115205915_-UTR3
ADediting_1159681chr5_115205916_-UTR3
ADediting_1159682chr5_115205918_-UTR3
ADediting_1159683chr5_115205925_-UTR3
ADediting_1159684chr5_115205967_-UTR3
ADediting_1159685chr5_115206004_-UTR3
ADediting_1159686chr5_115206005_-UTR3
ADediting_1159687chr5_115206017_-UTR3
ADediting_1159688chr5_115206020_-UTR3
ADediting_1159689chr5_115206031_-UTR3
ADediting_1159690chr5_115206036_-UTR3
ADediting_1159691chr5_115206038_-UTR3
ADediting_1159692chr5_115206042_-UTR3
ADediting_1159693chr5_115206044_-UTR3
ADediting_1159694chr5_115206058_-UTR3
ADediting_1159695chr5_115206616_-UTR3
ADediting_1159696chr5_115206621_-UTR3
ADediting_1159697chr5_115206627_-UTR3
ADediting_1159698chr5_115206632_-UTR3
ADediting_1159699chr5_115206635_-UTR3
ADediting_1159700chr5_115206637_-UTR3
ADediting_1159701chr5_115206642_-UTR3
ADediting_1159702chr5_115206647_-UTR3
ADediting_1159703chr5_115206651_-UTR3
ADediting_1159704chr5_115206667_-UTR3
ADediting_1159705chr5_115206668_-UTR3
ADediting_1159706chr5_115206672_-UTR3
ADediting_1159707chr5_115206680_-UTR3
ADediting_1159708chr5_115206681_-UTR3
ADediting_1159709chr5_115206689_-UTR3
ADediting_1159710chr5_115206691_-UTR3
ADediting_1159711chr5_115206695_-UTR3
ADediting_1159712chr5_115206697_-UTR3
ADediting_1159713chr5_115206702_-UTR3
ADediting_1159714chr5_115206705_-UTR3
ADediting_1159715chr5_115206706_-UTR3
ADediting_1159716chr5_115206712_-UTR3
ADediting_1159717chr5_115206714_-UTR3
ADediting_1159718chr5_115206716_-UTR3
ADediting_1159719chr5_115206719_-UTR3
ADediting_1159720chr5_115206720_-UTR3
ADediting_1159721chr5_115206724_-UTR3
ADediting_1159722chr5_115206726_-UTR3
ADediting_1159723chr5_115206727_-UTR3
ADediting_1159724chr5_115206728_-UTR3
ADediting_1159725chr5_115206734_-UTR3
ADediting_1159726chr5_115206735_-UTR3
ADediting_1159727chr5_115206736_-UTR3
ADediting_1159728chr5_115206738_-UTR3
ADediting_1159729chr5_115206739_-UTR3
ADediting_1159730chr5_115206740_-UTR3
ADediting_1159731chr5_115206745_-UTR3
ADediting_1159732chr5_115206751_-UTR3
ADediting_1159733chr5_115206753_-UTR3
ADediting_1159734chr5_115206757_-UTR3
ADediting_1159735chr5_115206764_-UTR3
ADediting_1159736chr5_115206768_-UTR3
ADediting_1159737chr5_115206780_-UTR3
ADediting_1159738chr5_115206782_-UTR3
ADediting_1159739chr5_115206789_-UTR3
ADediting_1159740chr5_115206790_-UTR3
ADediting_1159741chr5_115206791_-UTR3
ADediting_1159742chr5_115244209_-intronic
ADediting_1159743chr5_115244276_-intronic
ADediting_1159744chr5_115244365_-intronic
ADediting_1159745chr5_115244402_-intronic
ADediting_1159746chr5_115244459_-intronic
ADediting_1159747chr5_115244654_-intronic
ADediting_1159748chr5_115244742_-intronic
ADediting_1159749chr5_115244770_-intronic
ADediting_1159750chr5_115244773_-intronic
ADediting_1159751chr5_115244794_-intronic
ADediting_1159752chr5_115244795_-intronic
ADediting_1159753chr5_115244804_-intronic
ADediting_1159754chr5_115244814_-intronic
ADediting_1159755chr5_115244818_-intronic
ADediting_1159756chr5_115244833_-intronic
ADediting_1159757chr5_115244837_-intronic
ADediting_1159758chr5_115244842_-intronic
ADediting_1159759chr5_115244863_-intronic
ADediting_1159760chr5_115244864_-intronic
ADediting_1578742chr5_115205853_-UTR3
ADediting_1578743chr5_115205893_-UTR3
ADediting_1578744chr5_115205910_-UTR3
ADediting_1578745chr5_115238358_-intronic

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_1159653chr5_115205821_-LINEL1Name=L1ME3A
ADediting_1159654chr5_115205822_-LINEL1Name=L1ME3A
ADediting_1159655chr5_115205823_-LINEL1Name=L1ME3A
ADediting_1159656chr5_115205824_-LINEL1Name=L1ME3A
ADediting_1159657chr5_115205836_-LINEL1Name=L1ME3A
ADediting_1159658chr5_115205840_-LINEL1Name=L1ME3A
ADediting_1159659chr5_115205841_-LINEL1Name=L1ME3A
ADediting_1159660chr5_115205843_-LINEL1Name=L1ME3A
ADediting_1159661chr5_115205845_-LINEL1Name=L1ME3A
ADediting_1159662chr5_115205847_-LINEL1Name=L1ME3A
ADediting_1159663chr5_115205851_-LINEL1Name=L1ME3A
ADediting_1159664chr5_115205852_-LINEL1Name=L1ME3A
ADediting_1159665chr5_115205869_-LINEL1Name=L1ME3A
ADediting_1159666chr5_115205876_-LINEL1Name=L1ME3A
ADediting_1159667chr5_115205877_-LINEL1Name=L1ME3A
ADediting_1159668chr5_115205879_-LINEL1Name=L1ME3A
ADediting_1159669chr5_115205883_-LINEL1Name=L1ME3A
ADediting_1159670chr5_115205884_-LINEL1Name=L1ME3A
ADediting_1159671chr5_115205885_-LINEL1Name=L1ME3A
ADediting_1159672chr5_115205886_-LINEL1Name=L1ME3A
ADediting_1159673chr5_115205895_-LINEL1Name=L1ME3A
ADediting_1159674chr5_115205904_-LINEL1Name=L1ME3A
ADediting_1159675chr5_115205906_-LINEL1Name=L1ME3A
ADediting_1159676chr5_115205907_-LINEL1Name=L1ME3A
ADediting_1159677chr5_115205908_-LINEL1Name=L1ME3A
ADediting_1159678chr5_115205909_-LINEL1Name=L1ME3A
ADediting_1159679chr5_115205912_-LINEL1Name=L1ME3A
ADediting_1159680chr5_115205915_-LINEL1Name=L1ME3A
ADediting_1159681chr5_115205916_-LINEL1Name=L1ME3A
ADediting_1159682chr5_115205918_-LINEL1Name=L1ME3A
ADediting_1159683chr5_115205925_-LINEL1Name=L1ME3A
ADediting_1159684chr5_115205967_-DNATcMar-MarinerName=MADE1
ADediting_1159704chr5_115206667_-LINEL1Name=L1M5
ADediting_1159705chr5_115206668_-LINEL1Name=L1M5
ADediting_1159706chr5_115206672_-LINEL1Name=L1M5
ADediting_1159707chr5_115206680_-LINEL1Name=L1M5
ADediting_1159708chr5_115206681_-LINEL1Name=L1M5
ADediting_1159709chr5_115206689_-LINEL1Name=L1M5
ADediting_1159710chr5_115206691_-LINEL1Name=L1M5
ADediting_1159711chr5_115206695_-LINEL1Name=L1M5
ADediting_1159712chr5_115206697_-LINEL1Name=L1M5
ADediting_1159713chr5_115206702_-LINEL1Name=L1M5
ADediting_1159714chr5_115206705_-LINEL1Name=L1M5
ADediting_1159715chr5_115206706_-LINEL1Name=L1M5
ADediting_1159716chr5_115206712_-LINEL1Name=L1M5
ADediting_1159717chr5_115206714_-LINEL1Name=L1M5
ADediting_1159718chr5_115206716_-LINEL1Name=L1M5
ADediting_1159719chr5_115206719_-LINEL1Name=L1M5
ADediting_1159720chr5_115206720_-LINEL1Name=L1M5
ADediting_1159721chr5_115206724_-LINEL1Name=L1M5
ADediting_1159722chr5_115206726_-LINEL1Name=L1M5
ADediting_1159723chr5_115206727_-LINEL1Name=L1M5
ADediting_1159724chr5_115206728_-LINEL1Name=L1M5
ADediting_1159725chr5_115206734_-LINEL1Name=L1M5
ADediting_1159726chr5_115206735_-LINEL1Name=L1M5
ADediting_1159727chr5_115206736_-LINEL1Name=L1M5
ADediting_1159728chr5_115206738_-LINEL1Name=L1M5
ADediting_1159729chr5_115206739_-LINEL1Name=L1M5
ADediting_1159730chr5_115206740_-LINEL1Name=L1M5
ADediting_1159731chr5_115206745_-LINEL1Name=L1M5
ADediting_1159732chr5_115206751_-LINEL1Name=L1M5
ADediting_1159733chr5_115206753_-LINEL1Name=L1M5
ADediting_1159734chr5_115206757_-LINEL1Name=L1M5
ADediting_1159735chr5_115206764_-LINEL1Name=L1M5
ADediting_1159736chr5_115206768_-LINEL1Name=L1M5
ADediting_1159737chr5_115206780_-LINEL1Name=L1M5
ADediting_1159738chr5_115206782_-LINEL1Name=L1M5
ADediting_1159739chr5_115206789_-LINEL1Name=L1M5
ADediting_1159740chr5_115206790_-LINEL1Name=L1M5
ADediting_1159741chr5_115206791_-LINEL1Name=L1M5
ADediting_1159742chr5_115244209_-SINEAluName=AluY
ADediting_1159743chr5_115244276_-SINEAluName=AluY
ADediting_1159744chr5_115244365_-SINEAluName=AluY
ADediting_1159745chr5_115244402_-SINEAluName=AluY
ADediting_1159746chr5_115244459_-SINEAluName=AluY
ADediting_1159747chr5_115244654_-SINEAluName=AluSz
ADediting_1159748chr5_115244742_-SINEAluName=AluSz
ADediting_1159749chr5_115244770_-SINEAluName=AluSz
ADediting_1159750chr5_115244773_-SINEAluName=AluSz
ADediting_1159751chr5_115244794_-SINEAluName=AluSz
ADediting_1159752chr5_115244795_-SINEAluName=AluSz
ADediting_1159753chr5_115244804_-SINEAluName=AluSz
ADediting_1159754chr5_115244814_-SINEAluName=AluSz
ADediting_1159755chr5_115244818_-SINEAluName=AluSz
ADediting_1159756chr5_115244833_-SINEAluName=AluSz
ADediting_1159757chr5_115244837_-SINEAluName=AluSz
ADediting_1159758chr5_115244842_-SINEAluName=AluSz
ADediting_1159759chr5_115244863_-SINEAluName=AluSz
ADediting_1159760chr5_115244864_-SINEAluName=AluSz
ADediting_1578742chr5_115205853_-LINEL1Name=L1ME3A
ADediting_1578743chr5_115205893_-LINEL1Name=L1ME3A
ADediting_1578744chr5_115205910_-LINEL1Name=L1ME3A
ADediting_1578745chr5_115238358_-SINEAluName=AluJr

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RNA A-to-I editing events in the alternative splicing sites for PGGT1B

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for PGGT1B

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
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check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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ADeditome IDChrPositoingSkipped exonENSGENSTs