|
||||||
|
 | |
| |
| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
| |
| |
| The effects of the RNA editing to the stability of the RNA structures |
| |
| |
| |
|
Gene summary for PFKP |
 Gene summary |
| Gene information | Gene symbol | PFKP | Gene ID | 5214 |
| Gene name | phosphofructokinase, platelet | |
| Synonyms | ATP-PFK|PFK-C|PFK-P|PFKF | |
| Cytomap | 10p15.2 | |
| Type of gene | protein-coding | |
| Description | ATP-dependent 6-phosphofructokinase, platelet type6-phosphofructokinase type C6-phosphofructokinase, platelet typephosphofructo-1-kinase isozyme Cphosphofructokinase 1phosphohexokinase | |
| Modification date | 20200313 | |
| UniProtAcc | Q01813, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
Top |
RNA A-to-I events for PFKP |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
 |
| RNA editing frequencies across three data sets. |
 |
| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
 |
| RNA A-to-I editing events in AD. |
| ADediting_192254(3069628, +), ADediting_192255(3069633, +), ADediting_192256(3069654, +), ADediting_192257(3070781, +), ADediting_192258(3070833, +), ADediting_192259(3070850, +), ADediting_192260(3070851, +), ADediting_192261(3070931, +), ADediting_192262(3070948, +), ADediting_192263(3071012, +), ADediting_192264(3071013, +), ADediting_192265(3071025, +), ADediting_192266(3071034, +), ADediting_192267(3073917, +), ADediting_192268(3073932, +), ADediting_192269(3073938, +), ADediting_192270(3073963, +), ADediting_192271(3073964, +), ADediting_192272(3074021, +), ADediting_192273(3074037, +), ADediting_192274(3074100, +), ADediting_192275(3075647, +), ADediting_192276(3075648, +), ADediting_192277(3075653, +), ADediting_192278(3075661, +), ADediting_192279(3075670, +), ADediting_192280(3075717, +), ADediting_192281(3075724, +), ADediting_192282(3075725, +), ADediting_192283(3075758, +), ADediting_192284(3075778, +), ADediting_192285(3075782, +), ADediting_192286(3075784, +), ADediting_192287(3075807, +), ADediting_192288(3075825, +), ADediting_192289(3075830, +), ADediting_192290(3075875, +), ADediting_192291(3075940, +), ADediting_192292(3077326, +), ADediting_192293(3077342, +), ADediting_192294(3077362, +), ADediting_192295(3077379, +), ADediting_192296(3079258, +), ADediting_192297(3080255, +), ADediting_192298(3080262, +), ADediting_192299(3080263, +), ADediting_192300(3080271, +), ADediting_192301(3082776, +), ADediting_192302(3082780, +), ADediting_192303(3082813, +), ADediting_192329(3091653, +), ADediting_192333(3093737, +), ADediting_192369(3098421, +), ADediting_192370(3098554, +), ADediting_192412(3102064, +), ADediting_192413(3102074, +), ADediting_192414(3102130, +), ADediting_192415(3102136, +), ADediting_192416(3102140, +), ADediting_192417(3102450, +), ADediting_192418(3102513, +), ADediting_192419(3102514, +), ADediting_192420(3102517, +), ADediting_192421(3102518, +), ADediting_192422(3102540, +), ADediting_192423(3102543, +), ADediting_192424(3102553, +), ADediting_192425(3102555, +), ADediting_192426(3102559, +), ADediting_192427(3102632, +), ADediting_192428(3102641, +), ADediting_192429(3102675, +), ADediting_192432(3120729, +), ADediting_192433(3120734, +), ADediting_192434(3120739, +), ADediting_192435(3120746, +), ADediting_192436(3121915, +), ADediting_192437(3121934, +), ADediting_192438(3125611, +), ADediting_192439(3125983, +), ADediting_192440(3125985, +), ADediting_192441(3125988, +), ADediting_192442(3125990, +), ADediting_192443(3125991, +), ADediting_192444(3126006, +), ADediting_192445(3126014, +), ADediting_192446(3126485, +), ADediting_192447(3126487, +), ADediting_192448(3126502, +), ADediting_192449(3126514, +), ADediting_192516(3136143, +), ADediting_1523291(3070870, +), ADediting_1523292(3070957, +), ADediting_1523294(3133524, +), ADediting_1605412(3133510, +), ADediting_1605413(3133511, +), |
Top |
RNA editing positional annotations for PFKP using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_192254 | chr10_3069628_+ | intronic |
| ADediting_192255 | chr10_3069633_+ | intronic |
| ADediting_192256 | chr10_3069654_+ | intronic |
| ADediting_192257 | chr10_3070781_+ | intronic |
| ADediting_192258 | chr10_3070833_+ | intronic |
| ADediting_192259 | chr10_3070850_+ | intronic |
| ADediting_192260 | chr10_3070851_+ | intronic |
| ADediting_192261 | chr10_3070931_+ | intronic |
| ADediting_192262 | chr10_3070948_+ | intronic |
| ADediting_192263 | chr10_3071012_+ | intronic |
| ADediting_192264 | chr10_3071013_+ | intronic |
| ADediting_192265 | chr10_3071025_+ | intronic |
| ADediting_192266 | chr10_3071034_+ | intronic |
| ADediting_192267 | chr10_3073917_+ | intronic |
| ADediting_192268 | chr10_3073932_+ | intronic |
| ADediting_192269 | chr10_3073938_+ | intronic |
| ADediting_192270 | chr10_3073963_+ | intronic |
| ADediting_192271 | chr10_3073964_+ | intronic |
| ADediting_192272 | chr10_3074021_+ | intronic |
| ADediting_192273 | chr10_3074037_+ | intronic |
| ADediting_192274 | chr10_3074100_+ | intronic |
| ADediting_192275 | chr10_3075647_+ | intronic |
| ADediting_192276 | chr10_3075648_+ | intronic |
| ADediting_192277 | chr10_3075653_+ | intronic |
| ADediting_192278 | chr10_3075661_+ | intronic |
| ADediting_192279 | chr10_3075670_+ | intronic |
| ADediting_192280 | chr10_3075717_+ | intronic |
| ADediting_192281 | chr10_3075724_+ | intronic |
| ADediting_192282 | chr10_3075725_+ | intronic |
| ADediting_192283 | chr10_3075758_+ | intronic |
| ADediting_192284 | chr10_3075778_+ | intronic |
| ADediting_192285 | chr10_3075782_+ | intronic |
| ADediting_192286 | chr10_3075784_+ | intronic |
| ADediting_192287 | chr10_3075807_+ | intronic |
| ADediting_192288 | chr10_3075825_+ | intronic |
| ADediting_192289 | chr10_3075830_+ | intronic |
| ADediting_192290 | chr10_3075875_+ | intronic |
| ADediting_192291 | chr10_3075940_+ | intronic |
| ADediting_192292 | chr10_3077326_+ | intronic |
| ADediting_192293 | chr10_3077342_+ | intronic |
| ADediting_192294 | chr10_3077362_+ | intronic |
| ADediting_192295 | chr10_3077379_+ | intronic |
| ADediting_192296 | chr10_3079258_+ | intronic |
| ADediting_192297 | chr10_3080255_+ | intronic |
| ADediting_192298 | chr10_3080262_+ | intronic |
| ADediting_192299 | chr10_3080263_+ | intronic |
| ADediting_192300 | chr10_3080271_+ | intronic |
| ADediting_192301 | chr10_3082776_+ | intronic |
| ADediting_192302 | chr10_3082780_+ | intronic |
| ADediting_192303 | chr10_3082813_+ | intronic |
| ADediting_192329 | chr10_3091653_+ | intronic |
| ADediting_192333 | chr10_3093737_+ | intronic |
| ADediting_192369 | chr10_3098421_+ | intronic |
| ADediting_192370 | chr10_3098554_+ | intronic |
| ADediting_192412 | chr10_3102064_+ | intronic |
| ADediting_192413 | chr10_3102074_+ | intronic |
| ADediting_192414 | chr10_3102130_+ | intronic |
| ADediting_192415 | chr10_3102136_+ | intronic |
| ADediting_192416 | chr10_3102140_+ | intronic |
| ADediting_192417 | chr10_3102450_+ | intronic |
| ADediting_192418 | chr10_3102513_+ | intronic |
| ADediting_192419 | chr10_3102514_+ | intronic |
| ADediting_192420 | chr10_3102517_+ | intronic |
| ADediting_192421 | chr10_3102518_+ | intronic |
| ADediting_192422 | chr10_3102540_+ | intronic |
| ADediting_192423 | chr10_3102543_+ | intronic |
| ADediting_192424 | chr10_3102553_+ | intronic |
| ADediting_192425 | chr10_3102555_+ | intronic |
| ADediting_192426 | chr10_3102559_+ | intronic |
| ADediting_192427 | chr10_3102632_+ | intronic |
| ADediting_192428 | chr10_3102641_+ | intronic |
| ADediting_192429 | chr10_3102675_+ | intronic |
| ADediting_192432 | chr10_3120729_+ | intronic |
| ADediting_192433 | chr10_3120734_+ | intronic |
| ADediting_192434 | chr10_3120739_+ | intronic |
| ADediting_192435 | chr10_3120746_+ | intronic |
| ADediting_192436 | chr10_3121915_+ | intronic |
| ADediting_192437 | chr10_3121934_+ | intronic |
| ADediting_192438 | chr10_3125611_+ | intronic |
| ADediting_192439 | chr10_3125983_+ | intronic |
| ADediting_192440 | chr10_3125985_+ | intronic |
| ADediting_192441 | chr10_3125988_+ | intronic |
| ADediting_192442 | chr10_3125990_+ | intronic |
| ADediting_192443 | chr10_3125991_+ | intronic |
| ADediting_192444 | chr10_3126006_+ | intronic |
| ADediting_192445 | chr10_3126014_+ | intronic |
| ADediting_192446 | chr10_3126485_+ | intronic |
| ADediting_192447 | chr10_3126487_+ | intronic |
| ADediting_192448 | chr10_3126502_+ | intronic |
| ADediting_192449 | chr10_3126514_+ | intronic |
| ADediting_192516 | chr10_3136143_+ | ncRNA_intronic |
| ADediting_1523291 | chr10_3070870_+ | intronic |
| ADediting_1523292 | chr10_3070957_+ | intronic |
| ADediting_1523294 | chr10_3133524_+ | intronic |
| ADediting_1605412 | chr10_3133510_+ | intronic |
| ADediting_1605413 | chr10_3133511_+ | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_192254 | chr10_3069628_+ | SINE | Alu | Name=FLAM_C |
| ADediting_192255 | chr10_3069633_+ | SINE | Alu | Name=FLAM_C |
| ADediting_192256 | chr10_3069654_+ | SINE | Alu | Name=FLAM_C |
| ADediting_192257 | chr10_3070781_+ | SINE | Alu | Name=AluJr |
| ADediting_192258 | chr10_3070833_+ | SINE | Alu | Name=AluJr |
| ADediting_192259 | chr10_3070850_+ | SINE | Alu | Name=AluJr |
| ADediting_192260 | chr10_3070851_+ | SINE | Alu | Name=AluJr |
| ADediting_192261 | chr10_3070931_+ | SINE | Alu | Name=AluJr |
| ADediting_192262 | chr10_3070948_+ | SINE | Alu | Name=AluJr |
| ADediting_192263 | chr10_3071012_+ | SINE | Alu | Name=AluJr |
| ADediting_192264 | chr10_3071013_+ | SINE | Alu | Name=AluJr |
| ADediting_192265 | chr10_3071025_+ | SINE | Alu | Name=AluJr |
| ADediting_192266 | chr10_3071034_+ | SINE | Alu | Name=AluJr |
| ADediting_192267 | chr10_3073917_+ | SINE | Alu | Name=AluSz |
| ADediting_192268 | chr10_3073932_+ | SINE | Alu | Name=AluSz |
| ADediting_192269 | chr10_3073938_+ | SINE | Alu | Name=AluSz |
| ADediting_192270 | chr10_3073963_+ | SINE | Alu | Name=AluSz |
| ADediting_192271 | chr10_3073964_+ | SINE | Alu | Name=AluSz |
| ADediting_192272 | chr10_3074021_+ | SINE | Alu | Name=AluSz |
| ADediting_192273 | chr10_3074037_+ | SINE | Alu | Name=AluSz |
| ADediting_192274 | chr10_3074100_+ | SINE | Alu | Name=AluSz |
| ADediting_192275 | chr10_3075647_+ | SINE | Alu | Name=AluJo |
| ADediting_192276 | chr10_3075648_+ | SINE | Alu | Name=AluJo |
| ADediting_192277 | chr10_3075653_+ | SINE | Alu | Name=AluJo |
| ADediting_192278 | chr10_3075661_+ | SINE | Alu | Name=AluJo |
| ADediting_192279 | chr10_3075670_+ | SINE | Alu | Name=AluJo |
| ADediting_192280 | chr10_3075717_+ | SINE | Alu | Name=AluJo |
| ADediting_192281 | chr10_3075724_+ | SINE | Alu | Name=AluJo |
| ADediting_192282 | chr10_3075725_+ | SINE | Alu | Name=AluJo |
| ADediting_192283 | chr10_3075758_+ | SINE | Alu | Name=AluJo |
| ADediting_192284 | chr10_3075778_+ | SINE | Alu | Name=AluJo |
| ADediting_192285 | chr10_3075782_+ | SINE | Alu | Name=AluJo |
| ADediting_192286 | chr10_3075784_+ | SINE | Alu | Name=AluJo |
| ADediting_192287 | chr10_3075807_+ | SINE | Alu | Name=AluJo |
| ADediting_192288 | chr10_3075825_+ | SINE | Alu | Name=AluJo |
| ADediting_192289 | chr10_3075830_+ | SINE | Alu | Name=AluJo |
| ADediting_192290 | chr10_3075875_+ | SINE | Alu | Name=AluJo |
| ADediting_192291 | chr10_3075940_+ | SINE | Alu | Name=AluYb8 |
| ADediting_192292 | chr10_3077326_+ | SINE | Alu | Name=AluSc8 |
| ADediting_192293 | chr10_3077342_+ | SINE | Alu | Name=AluSc8 |
| ADediting_192294 | chr10_3077362_+ | SINE | Alu | Name=AluSc8 |
| ADediting_192295 | chr10_3077379_+ | SINE | Alu | Name=AluSc8 |
| ADediting_192296 | chr10_3079258_+ | SINE | Alu | Name=AluY |
| ADediting_192297 | chr10_3080255_+ | SINE | Alu | Name=AluYm1 |
| ADediting_192298 | chr10_3080262_+ | SINE | Alu | Name=AluYm1 |
| ADediting_192299 | chr10_3080263_+ | SINE | Alu | Name=AluYm1 |
| ADediting_192300 | chr10_3080271_+ | SINE | Alu | Name=AluYm1 |
| ADediting_192301 | chr10_3082776_+ | SINE | Alu | Name=AluSx1 |
| ADediting_192302 | chr10_3082780_+ | SINE | Alu | Name=AluSx1 |
| ADediting_192303 | chr10_3082813_+ | SINE | Alu | Name=AluSx1 |
| ADediting_192329 | chr10_3091653_+ | SINE | Alu | Name=AluSz |
| ADediting_192333 | chr10_3093737_+ | SINE | Alu | Name=AluY |
| ADediting_192369 | chr10_3098421_+ | SINE | Alu | Name=AluSx1 |
| ADediting_192370 | chr10_3098554_+ | SINE | Alu | Name=AluSx1 |
| ADediting_192412 | chr10_3102064_+ | SINE | Alu | Name=AluYa5 |
| ADediting_192413 | chr10_3102074_+ | SINE | Alu | Name=AluYa5 |
| ADediting_192414 | chr10_3102130_+ | SINE | Alu | Name=AluYa5 |
| ADediting_192415 | chr10_3102136_+ | SINE | Alu | Name=AluYa5 |
| ADediting_192416 | chr10_3102140_+ | SINE | Alu | Name=AluYa5 |
| ADediting_192417 | chr10_3102450_+ | SINE | Alu | Name=AluSx |
| ADediting_192418 | chr10_3102513_+ | SINE | Alu | Name=AluSx |
| ADediting_192419 | chr10_3102514_+ | SINE | Alu | Name=AluSx |
| ADediting_192420 | chr10_3102517_+ | SINE | Alu | Name=AluSx |
| ADediting_192421 | chr10_3102518_+ | SINE | Alu | Name=AluSx |
| ADediting_192422 | chr10_3102540_+ | SINE | Alu | Name=AluSx |
| ADediting_192423 | chr10_3102543_+ | SINE | Alu | Name=AluSx |
| ADediting_192424 | chr10_3102553_+ | SINE | Alu | Name=AluSx |
| ADediting_192425 | chr10_3102555_+ | SINE | Alu | Name=AluSx |
| ADediting_192426 | chr10_3102559_+ | SINE | Alu | Name=AluSx |
| ADediting_192427 | chr10_3102632_+ | SINE | Alu | Name=AluSx |
| ADediting_192428 | chr10_3102641_+ | SINE | Alu | Name=AluSx |
| ADediting_192429 | chr10_3102675_+ | SINE | Alu | Name=AluSx |
| ADediting_192432 | chr10_3120729_+ | SINE | Alu | Name=AluJb |
| ADediting_192433 | chr10_3120734_+ | SINE | Alu | Name=AluJb |
| ADediting_192434 | chr10_3120739_+ | SINE | Alu | Name=AluJb |
| ADediting_192435 | chr10_3120746_+ | SINE | Alu | Name=AluJb |
| ADediting_192436 | chr10_3121915_+ | SINE | Alu | Name=AluJb |
| ADediting_192437 | chr10_3121934_+ | SINE | Alu | Name=AluJb |
| ADediting_192516 | chr10_3136143_+ | SINE | Alu | Name=AluSc |
| ADediting_1523291 | chr10_3070870_+ | SINE | Alu | Name=AluJr |
| ADediting_1523292 | chr10_3070957_+ | SINE | Alu | Name=AluJr |
| ADediting_1523294 | chr10_3133524_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1605412 | chr10_3133510_+ | SINE | Alu | Name=AluSx1 |
| ADediting_1605413 | chr10_3133511_+ | SINE | Alu | Name=AluSx1 |
Top |
RNA A-to-I editing events in the alternative splicing sites for PFKP |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| ME2 | ADediting_192438 | chr10_3125611_+ | 3125606:3125614 | 5ss | 3i | CCGGTAAGT | 10.91 | CCGGTGAGT | 10.90 |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
Top |
Differntial gene expression between RNA A-to-I edited versus non-edited samples for PFKP |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
 | |
 | |
 | |
 | |
 | |
 | |
| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
 |
 |
 |
| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |