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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for PFDN5 |
 Gene summary |
| Gene information | Gene symbol | PFDN5 | Gene ID | 5204 |
| Gene name | prefoldin subunit 5 | |
| Synonyms | MM-1|MM1|PFD5 | |
| Cytomap | 12q13.13 | |
| Type of gene | protein-coding | |
| Description | prefoldin subunit 5c-myc binding proteinmyc modulator-1 | |
| Modification date | 20200313 | |
| UniProtAcc | Q99471, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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RNA A-to-I events for PFDN5 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_354988(53296435, +), ADediting_354989(53296503, +), ADediting_354990(53296508, +), ADediting_354991(53296509, +), ADediting_354992(53296511, +), ADediting_354993(53296526, +), ADediting_354994(53296538, +), ADediting_354995(53296550, +), ADediting_354996(53296592, +), ADediting_354997(53296610, +), ADediting_354998(53296612, +), ADediting_354999(53296631, +), ADediting_355000(53296676, +), ADediting_355001(53297119, +), ADediting_355002(53297147, +), ADediting_355003(53297151, +), ADediting_355004(53297174, +), ADediting_355005(53297179, +), ADediting_355006(53297195, +), ADediting_355007(53297204, +), ADediting_355008(53297219, +), ADediting_355009(53297226, +), ADediting_355010(53297245, +), ADediting_355011(53297267, +), ADediting_355012(53297273, +), ADediting_355013(53297275, +), ADediting_355014(53297276, +), ADediting_355015(53297277, +), ADediting_355016(53297278, +), ADediting_355017(53297279, +), ADediting_355018(53297282, +), ADediting_355019(53297286, +), ADediting_355020(53297298, +), ADediting_355021(53297300, +), ADediting_355022(53297309, +), ADediting_355023(53297318, +), ADediting_355024(53297350, +), ADediting_355025(53297355, +), ADediting_355026(53297361, +), ADediting_355027(53297394, +), ADediting_355028(53297400, +), ADediting_1533099(53296489, +), ADediting_1533100(53296561, +), ADediting_1533101(53296589, +), ADediting_1533102(53296619, +), ADediting_1533103(53296647, +), ADediting_1533104(53297271, +), ADediting_1533105(53297314, +), ADediting_1533106(53297335, +), ADediting_1533107(53297341, +), ADediting_1533108(53297349, +), ADediting_1614179(53297308, +), |
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RNA editing positional annotations for PFDN5 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| ADediting_354988 | chr12_53296435_+ | synonymous SNV | ENST00000550880.5 | c.A78G | p.E26E | . | . | . |
| ADediting_354988 | chr12_53296435_+ | synonymous SNV | ENST00000628881.1 | c.A78G | p.E26E | . | . | . |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_354988 | chr12_53296435_+ | exonic |
| ADediting_354989 | chr12_53296503_+ | UTR3 |
| ADediting_354990 | chr12_53296508_+ | UTR3 |
| ADediting_354991 | chr12_53296509_+ | UTR3 |
| ADediting_354992 | chr12_53296511_+ | UTR3 |
| ADediting_354993 | chr12_53296526_+ | UTR3 |
| ADediting_354994 | chr12_53296538_+ | UTR3 |
| ADediting_354995 | chr12_53296550_+ | UTR3 |
| ADediting_354996 | chr12_53296592_+ | intronic |
| ADediting_354997 | chr12_53296610_+ | intronic |
| ADediting_354998 | chr12_53296612_+ | intronic |
| ADediting_354999 | chr12_53296631_+ | intronic |
| ADediting_355000 | chr12_53296676_+ | intronic |
| ADediting_355001 | chr12_53297119_+ | intronic |
| ADediting_355002 | chr12_53297147_+ | intronic |
| ADediting_355003 | chr12_53297151_+ | intronic |
| ADediting_355004 | chr12_53297174_+ | intronic |
| ADediting_355005 | chr12_53297179_+ | intronic |
| ADediting_355006 | chr12_53297195_+ | intronic |
| ADediting_355007 | chr12_53297204_+ | intronic |
| ADediting_355008 | chr12_53297219_+ | intronic |
| ADediting_355009 | chr12_53297226_+ | intronic |
| ADediting_355010 | chr12_53297245_+ | intronic |
| ADediting_355011 | chr12_53297267_+ | intronic |
| ADediting_355012 | chr12_53297273_+ | intronic |
| ADediting_355013 | chr12_53297275_+ | intronic |
| ADediting_355014 | chr12_53297276_+ | intronic |
| ADediting_355015 | chr12_53297277_+ | intronic |
| ADediting_355016 | chr12_53297278_+ | intronic |
| ADediting_355017 | chr12_53297279_+ | intronic |
| ADediting_355018 | chr12_53297282_+ | intronic |
| ADediting_355019 | chr12_53297286_+ | intronic |
| ADediting_355020 | chr12_53297298_+ | intronic |
| ADediting_355021 | chr12_53297300_+ | intronic |
| ADediting_355022 | chr12_53297309_+ | intronic |
| ADediting_355023 | chr12_53297318_+ | intronic |
| ADediting_355024 | chr12_53297350_+ | intronic |
| ADediting_355025 | chr12_53297355_+ | intronic |
| ADediting_355026 | chr12_53297361_+ | intronic |
| ADediting_355027 | chr12_53297394_+ | intronic |
| ADediting_355028 | chr12_53297400_+ | intronic |
| ADediting_1533099 | chr12_53296489_+ | UTR3 |
| ADediting_1533100 | chr12_53296561_+ | intronic |
| ADediting_1533101 | chr12_53296589_+ | intronic |
| ADediting_1533102 | chr12_53296619_+ | intronic |
| ADediting_1533103 | chr12_53296647_+ | intronic |
| ADediting_1533104 | chr12_53297271_+ | intronic |
| ADediting_1533105 | chr12_53297314_+ | intronic |
| ADediting_1533106 | chr12_53297335_+ | intronic |
| ADediting_1533107 | chr12_53297341_+ | intronic |
| ADediting_1533108 | chr12_53297349_+ | intronic |
| ADediting_1614179 | chr12_53297308_+ | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_354988 | chr12_53296435_+ | SINE | Alu | Name=AluSx4 |
| ADediting_354989 | chr12_53296503_+ | SINE | Alu | Name=AluSx4 |
| ADediting_354990 | chr12_53296508_+ | SINE | Alu | Name=AluSx4 |
| ADediting_354991 | chr12_53296509_+ | SINE | Alu | Name=AluSx4 |
| ADediting_354992 | chr12_53296511_+ | SINE | Alu | Name=AluSx4 |
| ADediting_354993 | chr12_53296526_+ | SINE | Alu | Name=AluSx4 |
| ADediting_354994 | chr12_53296538_+ | SINE | Alu | Name=AluSx4 |
| ADediting_354995 | chr12_53296550_+ | SINE | Alu | Name=AluSx4 |
| ADediting_354996 | chr12_53296592_+ | SINE | Alu | Name=AluSx4 |
| ADediting_354997 | chr12_53296610_+ | SINE | Alu | Name=AluSx4 |
| ADediting_354998 | chr12_53296612_+ | SINE | Alu | Name=AluSx4 |
| ADediting_354999 | chr12_53296631_+ | SINE | Alu | Name=AluSx4 |
| ADediting_355000 | chr12_53296676_+ | SINE | Alu | Name=AluSx4 |
| ADediting_355003 | chr12_53297151_+ | SINE | Alu | Name=AluSx |
| ADediting_355004 | chr12_53297174_+ | SINE | Alu | Name=AluSx |
| ADediting_355005 | chr12_53297179_+ | SINE | Alu | Name=AluSx |
| ADediting_355006 | chr12_53297195_+ | SINE | Alu | Name=AluSx |
| ADediting_355007 | chr12_53297204_+ | SINE | Alu | Name=AluSx |
| ADediting_355008 | chr12_53297219_+ | SINE | Alu | Name=AluSx |
| ADediting_355009 | chr12_53297226_+ | SINE | Alu | Name=AluSx |
| ADediting_355010 | chr12_53297245_+ | SINE | Alu | Name=AluSx |
| ADediting_355011 | chr12_53297267_+ | SINE | Alu | Name=AluSx |
| ADediting_355012 | chr12_53297273_+ | SINE | Alu | Name=AluSx |
| ADediting_355013 | chr12_53297275_+ | SINE | Alu | Name=AluSx |
| ADediting_355014 | chr12_53297276_+ | SINE | Alu | Name=AluSx |
| ADediting_355015 | chr12_53297277_+ | SINE | Alu | Name=AluSx |
| ADediting_355016 | chr12_53297278_+ | SINE | Alu | Name=AluSx |
| ADediting_355017 | chr12_53297279_+ | SINE | Alu | Name=AluSx |
| ADediting_355018 | chr12_53297282_+ | SINE | Alu | Name=AluSx |
| ADediting_355019 | chr12_53297286_+ | SINE | Alu | Name=AluSx |
| ADediting_355020 | chr12_53297298_+ | SINE | Alu | Name=AluSx |
| ADediting_355021 | chr12_53297300_+ | SINE | Alu | Name=AluSx |
| ADediting_355022 | chr12_53297309_+ | SINE | Alu | Name=AluSx |
| ADediting_355023 | chr12_53297318_+ | SINE | Alu | Name=AluSx |
| ADediting_355024 | chr12_53297350_+ | SINE | Alu | Name=AluSx |
| ADediting_355025 | chr12_53297355_+ | SINE | Alu | Name=AluSx |
| ADediting_355026 | chr12_53297361_+ | SINE | Alu | Name=AluSx |
| ADediting_355027 | chr12_53297394_+ | SINE | Alu | Name=AluSx |
| ADediting_355028 | chr12_53297400_+ | SINE | Alu | Name=AluSx |
| ADediting_1533099 | chr12_53296489_+ | SINE | Alu | Name=AluSx4 |
| ADediting_1533100 | chr12_53296561_+ | SINE | Alu | Name=AluSx4 |
| ADediting_1533101 | chr12_53296589_+ | SINE | Alu | Name=AluSx4 |
| ADediting_1533102 | chr12_53296619_+ | SINE | Alu | Name=AluSx4 |
| ADediting_1533103 | chr12_53296647_+ | SINE | Alu | Name=AluSx4 |
| ADediting_1533104 | chr12_53297271_+ | SINE | Alu | Name=AluSx |
| ADediting_1533105 | chr12_53297314_+ | SINE | Alu | Name=AluSx |
| ADediting_1533106 | chr12_53297335_+ | SINE | Alu | Name=AluSx |
| ADediting_1533107 | chr12_53297341_+ | SINE | Alu | Name=AluSx |
| ADediting_1533108 | chr12_53297349_+ | SINE | Alu | Name=AluSx |
| ADediting_1614179 | chr12_53297308_+ | SINE | Alu | Name=AluSx |
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RNA A-to-I editing events in the alternative splicing sites for PFDN5 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| ES | ADediting_354988 | chr12_53296435_+ | 53296434:53296456 | 3ss | 19i | AATTTCGCTCTGTCGCCCAGGCT | 4.44 | AGTTTCGCTCTGTCGCCCAGGCT | 4.08 |
| ES | ADediting_354995 | chr12_53296550_+ | 53296549:53296557 | 5ss | 2e | TAGGTACGC | 7.84 | TGGGTACGC | 6.74 |
| ES | ADediting_354995 | chr12_53296550_+ | 53296549:53296557 | 5ss | 2e | TAGGTACGC | 7.84 | TGGGTACGC | 6.74 |
| ME1 | ADediting_354988 | chr12_53296435_+ | 53296434:53296456 | 3ss | 19i | AATTTCGCTCTGTCGCCCAGGCT | 4.44 | AGTTTCGCTCTGTCGCCCAGGCT | 4.08 |
| ME1 | ADediting_354988 | chr12_53296435_+ | 53296434:53296456 | 3ss | 19i | AATTTCGCTCTGTCGCCCAGGCT | 4.44 | AGTTTCGCTCTGTCGCCCAGGCT | 4.08 |
| ME1 | ADediting_354988 | chr12_53296435_+ | 53296434:53296456 | 3ss | 19i | AATTTCGCTCTGTCGCCCAGGCT | 4.44 | AGTTTCGCTCTGTCGCCCAGGCT | 4.08 |
| ME1 | ADediting_354988 | chr12_53296435_+ | 53296434:53296456 | 3ss | 19i | AATTTCGCTCTGTCGCCCAGGCT | 4.44 | AGTTTCGCTCTGTCGCCCAGGCT | 4.08 |
| ME1 | ADediting_354995 | chr12_53296550_+ | 53296549:53296557 | 5ss | 2e | TAGGTACGC | 7.84 | TGGGTACGC | 6.74 |
| ME1 | ADediting_354995 | chr12_53296550_+ | 53296549:53296557 | 5ss | 2e | TAGGTACGC | 7.84 | TGGGTACGC | 6.74 |
| ME1 | ADediting_354995 | chr12_53296550_+ | 53296549:53296557 | 5ss | 2e | TAGGTACGC | 7.84 | TGGGTACGC | 6.74 |
| ME1 | ADediting_354995 | chr12_53296550_+ | 53296549:53296557 | 5ss | 2e | TAGGTACGC | 7.84 | TGGGTACGC | 6.74 |
| ME1 | ADediting_354995 | chr12_53296550_+ | 53296549:53296557 | 5ss | 2e | TAGGTACGC | 7.84 | TGGGTACGC | 6.74 |
| ME1 | ADediting_354995 | chr12_53296550_+ | 53296549:53296557 | 5ss | 2e | TAGGTACGC | 7.84 | TGGGTACGC | 6.74 |
| ME1 | ADediting_354995 | chr12_53296550_+ | 53296549:53296557 | 5ss | 2e | TAGGTACGC | 7.84 | TGGGTACGC | 6.74 |
| ME1 | ADediting_354995 | chr12_53296550_+ | 53296549:53296557 | 5ss | 2e | TAGGTACGC | 7.84 | TGGGTACGC | 6.74 |
| ME2 | ADediting_354988 | chr12_53296435_+ | 53296434:53296456 | 3ss | 19i | AATTTCGCTCTGTCGCCCAGGCT | 4.44 | AGTTTCGCTCTGTCGCCCAGGCT | 4.08 |
| ME2 | ADediting_354988 | chr12_53296435_+ | 53296434:53296456 | 3ss | 19i | AATTTCGCTCTGTCGCCCAGGCT | 4.44 | AGTTTCGCTCTGTCGCCCAGGCT | 4.08 |
| ME2 | ADediting_354988 | chr12_53296435_+ | 53296434:53296456 | 3ss | 19i | AATTTCGCTCTGTCGCCCAGGCT | 4.44 | AGTTTCGCTCTGTCGCCCAGGCT | 4.08 |
| ME2 | ADediting_354988 | chr12_53296435_+ | 53296434:53296456 | 3ss | 19i | AATTTCGCTCTGTCGCCCAGGCT | 4.44 | AGTTTCGCTCTGTCGCCCAGGCT | 4.08 |
| ME2 | ADediting_354988 | chr12_53296435_+ | 53296434:53296456 | 3ss | 19i | AATTTCGCTCTGTCGCCCAGGCT | 4.44 | AGTTTCGCTCTGTCGCCCAGGCT | 4.08 |
| ME2 | ADediting_354988 | chr12_53296435_+ | 53296434:53296456 | 3ss | 19i | AATTTCGCTCTGTCGCCCAGGCT | 4.44 | AGTTTCGCTCTGTCGCCCAGGCT | 4.08 |
| ME2 | ADediting_354988 | chr12_53296435_+ | 53296434:53296456 | 3ss | 19i | AATTTCGCTCTGTCGCCCAGGCT | 4.44 | AGTTTCGCTCTGTCGCCCAGGCT | 4.08 |
| ME2 | ADediting_354988 | chr12_53296435_+ | 53296434:53296456 | 3ss | 19i | AATTTCGCTCTGTCGCCCAGGCT | 4.44 | AGTTTCGCTCTGTCGCCCAGGCT | 4.08 |
| ME2 | ADediting_354988 | chr12_53296435_+ | 53296434:53296456 | 3ss | 19i | AATTTCGCTCTGTCGCCCAGGCT | 4.44 | AGTTTCGCTCTGTCGCCCAGGCT | 4.08 |
| ME2 | ADediting_354988 | chr12_53296435_+ | 53296434:53296456 | 3ss | 19i | AATTTCGCTCTGTCGCCCAGGCT | 4.44 | AGTTTCGCTCTGTCGCCCAGGCT | 4.08 |
| ME2 | ADediting_354988 | chr12_53296435_+ | 53296434:53296456 | 3ss | 19i | AATTTCGCTCTGTCGCCCAGGCT | 4.44 | AGTTTCGCTCTGTCGCCCAGGCT | 4.08 |
| ME2 | ADediting_354988 | chr12_53296435_+ | 53296434:53296456 | 3ss | 19i | AATTTCGCTCTGTCGCCCAGGCT | 4.44 | AGTTTCGCTCTGTCGCCCAGGCT | 4.08 |
| ME2 | ADediting_354988 | chr12_53296435_+ | 53296434:53296456 | 3ss | 19i | AATTTCGCTCTGTCGCCCAGGCT | 4.44 | AGTTTCGCTCTGTCGCCCAGGCT | 4.08 |
| ME2 | ADediting_354995 | chr12_53296550_+ | 53296549:53296557 | 5ss | 2e | TAGGTACGC | 7.84 | TGGGTACGC | 6.74 |
| ME2 | ADediting_354995 | chr12_53296550_+ | 53296549:53296557 | 5ss | 2e | TAGGTACGC | 7.84 | TGGGTACGC | 6.74 |
| ME2 | ADediting_354995 | chr12_53296550_+ | 53296549:53296557 | 5ss | 2e | TAGGTACGC | 7.84 | TGGGTACGC | 6.74 |
| ME2 | ADediting_354995 | chr12_53296550_+ | 53296549:53296557 | 5ss | 2e | TAGGTACGC | 7.84 | TGGGTACGC | 6.74 |
| ME2 | ADediting_354995 | chr12_53296550_+ | 53296549:53296557 | 5ss | 2e | TAGGTACGC | 7.84 | TGGGTACGC | 6.74 |
| ME2 | ADediting_354995 | chr12_53296550_+ | 53296549:53296557 | 5ss | 2e | TAGGTACGC | 7.84 | TGGGTACGC | 6.74 |
| ME2 | ADediting_354995 | chr12_53296550_+ | 53296549:53296557 | 5ss | 2e | TAGGTACGC | 7.84 | TGGGTACGC | 6.74 |
| ME2 | ADediting_354995 | chr12_53296550_+ | 53296549:53296557 | 5ss | 2e | TAGGTACGC | 7.84 | TGGGTACGC | 6.74 |
| ME2 | ADediting_354995 | chr12_53296550_+ | 53296549:53296557 | 5ss | 2e | TAGGTACGC | 7.84 | TGGGTACGC | 6.74 |
| ME2 | ADediting_354995 | chr12_53296550_+ | 53296549:53296557 | 5ss | 2e | TAGGTACGC | 7.84 | TGGGTACGC | 6.74 |
| ME2 | ADediting_354995 | chr12_53296550_+ | 53296549:53296557 | 5ss | 2e | TAGGTACGC | 7.84 | TGGGTACGC | 6.74 |
| ME2 | ADediting_354995 | chr12_53296550_+ | 53296549:53296557 | 5ss | 2e | TAGGTACGC | 7.84 | TGGGTACGC | 6.74 |
| ME2 | ADediting_354995 | chr12_53296550_+ | 53296549:53296557 | 5ss | 2e | TAGGTACGC | 7.84 | TGGGTACGC | 6.74 |
| ME2 | ADediting_354995 | chr12_53296550_+ | 53296549:53296557 | 5ss | 2e | TAGGTACGC | 7.84 | TGGGTACGC | 6.74 |
| ME2 | ADediting_354995 | chr12_53296550_+ | 53296549:53296557 | 5ss | 2e | TAGGTACGC | 7.84 | TGGGTACGC | 6.74 |
| ME2 | ADediting_354995 | chr12_53296550_+ | 53296549:53296557 | 5ss | 2e | TAGGTACGC | 7.84 | TGGGTACGC | 6.74 |
| ME2 | ADediting_354995 | chr12_53296550_+ | 53296549:53296557 | 5ss | 2e | TAGGTACGC | 7.84 | TGGGTACGC | 6.74 |
| ME2 | ADediting_354995 | chr12_53296550_+ | 53296549:53296557 | 5ss | 2e | TAGGTACGC | 7.84 | TGGGTACGC | 6.74 |
| ME2 | ADediting_354995 | chr12_53296550_+ | 53296549:53296557 | 5ss | 2e | TAGGTACGC | 7.84 | TGGGTACGC | 6.74 |
| ME2 | ADediting_354995 | chr12_53296550_+ | 53296549:53296557 | 5ss | 2e | TAGGTACGC | 7.84 | TGGGTACGC | 6.74 |
| ME2 | ADediting_354995 | chr12_53296550_+ | 53296549:53296557 | 5ss | 2e | TAGGTACGC | 7.84 | TGGGTACGC | 6.74 |
| ME2 | ADediting_354995 | chr12_53296550_+ | 53296549:53296557 | 5ss | 2e | TAGGTACGC | 7.84 | TGGGTACGC | 6.74 |
| ME2 | ADediting_354995 | chr12_53296550_+ | 53296549:53296557 | 5ss | 2e | TAGGTACGC | 7.84 | TGGGTACGC | 6.74 |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for PFDN5 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for PFDN5 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for PFDN5 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for PFDN5 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000628881.1 | protein_coding |  |  |
| ENST00000549759.1 | protein_coding |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_354988 | ENST00000628881.1 | chr12_53296435_+ | 195 | -81.00 | -76.90 | -81.00 |
| ADediting_354988 | ENST00000549759.1 | chr12_53296435_+ | 167 | -187.50 | -188.30 | -187.50 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for PFDN5 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | ADediting_354988 | chr12_53296435_+ | 0.111004342101492 | 0.0906955500584189 | 0.0118231576506331 | 0.142820790457789 | 1.43724839103248e-09 | 0.335056635785678 |
| DLPFC | ADediting_354996 | chr12_53296592_+ | 0.0333619981758742 | 0.12089004660709 | 0.379137790879081 | 0.0501225300191339 | 5.66888333595842e-13 | 0.394287543671743 |
| CER | ADediting_354996 | chr12_53296592_+ | 1.51940683120355e-05 | 0.345174472042718 | 3.4951152741245e-05 | 0.331099517402451 | 0.554980900888734 | 0.0485767447784333 |
| DLPFC | ADediting_354998 | chr12_53296612_+ | 0.00347565874997911 | 0.165492569256496 | 0.0325121508982886 | 0.121474148440119 | 3.00114900486667e-10 | 0.347911045761223 |
| CER | ADediting_354998 | chr12_53296612_+ | 7.20750465332156e-06 | 0.357225060497424 | 1.91145980395693e-05 | 0.34136356756609 | 0.505558086128192 | 0.0547773008226117 |
| TCX | ADediting_355000 | chr12_53296676_+ | 0.630985586488454 | 0.0395349932280606 | 0.303292214629539 | -0.0846070418921983 | 0.000168909906763744 | 0.302429806627654 |
| CER | ADediting_355001 | chr12_53297119_+ | 0.00010072912471434 | 0.312161147610275 | 0.0467834734648923 | 0.162618470386497 | 0.45433667547725 | -0.0615475858426858 |
| DLPFC | ADediting_355007 | chr12_53297204_+ | 0.00946517987107651 | 0.147164794568093 | 0.0800516425270334 | 0.0995703233817197 | 2.11629178421423e-08 | 0.311491977086551 |
| CER | ADediting_355007 | chr12_53297204_+ | 0.000316931840689331 | 0.290102623783274 | 6.84621913380484e-05 | 0.319216989289769 | 0.0421857743743215 | 0.166121433704426 |
| DLPFC | ADediting_355009 | chr12_53297226_+ | 0.00114313386474174 | 0.183905815483937 | 0.00496523435279774 | 0.159180890526028 | 6.92782683745592e-08 | 0.300413270361865 |
| CER | ADediting_355009 | chr12_53297226_+ | 2.92307485572978e-08 | 0.433832927282127 | 6.73620286638232e-07 | 0.392578488812275 | 0.605613329639384 | 0.0424958537124211 |
| TCX | ADediting_355009 | chr12_53297226_+ | 0.443343981729352 | 0.0630544125136928 | 0.767477101122943 | -0.0243419435434853 | 0.000172377483670245 | 0.302040233073067 |
| DLPFC | ADediting_355012 | chr12_53297273_+ | 1.38489859511808e-06 | 0.270141782434189 | 0.000270096038574403 | 0.205493132092862 | 2.50822846211551e-09 | 0.33034062744264 |
| TCX | ADediting_355012 | chr12_53297273_+ | 0.570620348127133 | 0.0466718191168571 | 0.751473693019002 | -0.0260718905259664 | 2.93544178512547e-05 | 0.33410503228181 |
| CER | ADediting_355026 | chr12_53297361_+ | 0.0103296926381418 | 0.208831082012636 | 2.86250204325621e-05 | 0.334535822477891 | 0.291605895441078 | 0.0866710502102486 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 9.02941484587752e-19 | 0.474019155810257 | 2.17454112002444e-28 | 0.572486607411358 | 0.039742251992304 | 0.116868291642896 |
| AC | 6.0350381811289e-58 | 0.804124133476308 | 7.68748082820816e-42 | 0.723759937788155 | 3.01382587272651e-16 | 0.486328845857214 |
| PCC | 7.16560775229896e-10 | 0.427147521588393 | 2.28020497852098e-10 | 0.43828334596827 | 0.0199007077702397 | 0.168364499728231 |
| FP | 3.62117990193681e-09 | 0.42419525464195 | 6.74160828336393e-13 | 0.504774269098306 | 0.447934925750833 | -0.0572357276024718 |
| PG | 2.2599086712969e-16 | 0.554286367728711 | 2.59387421639497e-13 | 0.502849810181684 | 0.0536952549552617 | -0.14170278594575 |
| STG | 2.46354352643171e-15 | 0.732303982594896 | 1.57797493800212e-12 | 0.676828516158465 | 0.795076262816714 | 0.0287633949022901 |
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Relation with AD stages for PFDN5 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| TCX | ADediting_354998 | chr12_53296612_+ | 0.00137705008808211 | 0.306860295731963 |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
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RelatedDrugs for PFDN5 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PFDN5 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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