ADeditome: functional annotation of RNA A-to-I editing in AD

Gene summary for TMEM8B

Gene summary

Gene information	Gene symbol	TMEM8B
	Gene ID	51754
	Gene name	transmembrane protein 8B
	Synonyms	C9orf127\|FP588\|LINC00950\|NAG-5\|NAG5\|NGX6\|NGX6a
	Cytomap	9p13.3
	Type of gene	protein-coding
	Description	transmembrane protein 8Bnasopharyngeal carcinoma expressed 6nasopharyngeal carcinoma related proteinnasopharyngeal carcinoma-associated gene 6 protein
	Modification date	20200313
	UniProtAcc	A6NDV4,
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

Top

RNA A-to-I events for TMEM8B

RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).

RNA editing frequencies across three data sets.

The number of RNA A-to-I editing events in different types of transcripts (# event, percentage).

RNA A-to-I editing events in AD.

ADediting_1465869(35855463, +), ADediting_1465870(35855574, +), ADediting_1465871(35855577, +), ADediting_1465872(35858160, +), ADediting_1465873(35858169, +), ADediting_1465874(35858174, +), ADediting_1465875(35858179, +), ADediting_1465876(35858184, +), ADediting_1465877(35858198, +), ADediting_1465878(35858199, +), ADediting_1465879(35858231, +), ADediting_1465880(35858233, +), ADediting_1465881(35858271, +), ADediting_1465882(35858313, +), ADediting_1465883(35858325, +), ADediting_1465884(35858352, +), ADediting_1465885(35858353, +), ADediting_1465886(35858365, +), ADediting_1465887(35858383, +), ADediting_1465888(35863015, +), ADediting_1465889(35863047, +), ADediting_1465890(35863069, +), ADediting_1465891(35863074, +), ADediting_1465892(35863079, +), ADediting_1465893(35863093, +), ADediting_1465894(35863100, +), ADediting_1465895(35863103, +), ADediting_1593636(35858239, +), ADediting_1593637(35858255, +), ADediting_1593638(35863095, +),

Top

RNA editing positional annotations for TMEM8B using Annovar

Protein coding RNA editing(s).

ADeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

ADeditome ID	Position	Variant type
ADediting_1465869	chr9_35855463_+	UTR3
ADediting_1465870	chr9_35855574_+	UTR3
ADediting_1465871	chr9_35855577_+	UTR3
ADediting_1465872	chr9_35858160_+	UTR3
ADediting_1465873	chr9_35858169_+	UTR3
ADediting_1465874	chr9_35858174_+	UTR3
ADediting_1465875	chr9_35858179_+	UTR3
ADediting_1465876	chr9_35858184_+	UTR3
ADediting_1465877	chr9_35858198_+	UTR3
ADediting_1465878	chr9_35858199_+	UTR3
ADediting_1465879	chr9_35858231_+	UTR3
ADediting_1465880	chr9_35858233_+	UTR3
ADediting_1465881	chr9_35858271_+	UTR3
ADediting_1465882	chr9_35858313_+	UTR3
ADediting_1465883	chr9_35858325_+	UTR3
ADediting_1465884	chr9_35858352_+	UTR3
ADediting_1465885	chr9_35858353_+	UTR3
ADediting_1465886	chr9_35858365_+	UTR3
ADediting_1465887	chr9_35858383_+	UTR3
ADediting_1465888	chr9_35863015_+	UTR3
ADediting_1465889	chr9_35863047_+	UTR3
ADediting_1465890	chr9_35863069_+	UTR3
ADediting_1465891	chr9_35863074_+	UTR3
ADediting_1465892	chr9_35863079_+	UTR3
ADediting_1465893	chr9_35863093_+	UTR3
ADediting_1465894	chr9_35863100_+	UTR3
ADediting_1465895	chr9_35863103_+	UTR3
ADediting_1593636	chr9_35858239_+	UTR3
ADediting_1593637	chr9_35858255_+	UTR3
ADediting_1593638	chr9_35863095_+	UTR3

Repat-regional RNA editing(s).

ADeditome ID	Position	Repeat family	Repeat sub family	Repeat name
ADediting_1465869	chr9_35855463_+	SINE	Alu	Name=AluSp
ADediting_1465870	chr9_35855574_+	SINE	Alu	Name=AluSp
ADediting_1465871	chr9_35855577_+	SINE	Alu	Name=AluSp
ADediting_1465872	chr9_35858160_+	SINE	Alu	Name=AluSx
ADediting_1465873	chr9_35858169_+	SINE	Alu	Name=AluSx
ADediting_1465874	chr9_35858174_+	SINE	Alu	Name=AluSx
ADediting_1465875	chr9_35858179_+	SINE	Alu	Name=AluSx
ADediting_1465876	chr9_35858184_+	SINE	Alu	Name=AluSx
ADediting_1465877	chr9_35858198_+	SINE	Alu	Name=AluSx
ADediting_1465878	chr9_35858199_+	SINE	Alu	Name=AluSx
ADediting_1465879	chr9_35858231_+	SINE	Alu	Name=AluSx
ADediting_1465880	chr9_35858233_+	SINE	Alu	Name=AluSx
ADediting_1465881	chr9_35858271_+	SINE	Alu	Name=AluSx
ADediting_1465882	chr9_35858313_+	SINE	Alu	Name=AluSx
ADediting_1465883	chr9_35858325_+	SINE	Alu	Name=AluSx
ADediting_1465884	chr9_35858352_+	SINE	Alu	Name=AluSx
ADediting_1465885	chr9_35858353_+	SINE	Alu	Name=AluSx
ADediting_1465886	chr9_35858365_+	SINE	Alu	Name=AluSx
ADediting_1465887	chr9_35858383_+	SINE	Alu	Name=AluSx
ADediting_1465888	chr9_35863015_+	SINE	Alu	Name=AluJr
ADediting_1465889	chr9_35863047_+	SINE	Alu	Name=AluJr
ADediting_1465890	chr9_35863069_+	SINE	Alu	Name=AluJr
ADediting_1465891	chr9_35863074_+	SINE	Alu	Name=AluJr
ADediting_1465892	chr9_35863079_+	SINE	Alu	Name=AluJr
ADediting_1465893	chr9_35863093_+	SINE	Alu	Name=AluJr
ADediting_1465894	chr9_35863100_+	SINE	Alu	Name=AluJr
ADediting_1465895	chr9_35863103_+	SINE	Alu	Name=AluJr
ADediting_1593636	chr9_35858239_+	SINE	Alu	Name=AluSx
ADediting_1593637	chr9_35858255_+	SINE	Alu	Name=AluSx
ADediting_1593638	chr9_35863095_+	SINE	Alu	Name=AluJr

Top

RNA A-to-I editing events in the alternative splicing sites for TMEM8B

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

ADeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

Top

Differntial gene expression between RNA A-to-I edited versus non-edited samples for TMEM8B

Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

- Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

ADeditome ID

Chr

Positoing

Skipped exon

ENSG

ENSTs

Top

Protein coding region RNA A-to-I editings for TMEM8B

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

Top

The effects of the RNA editing to the miRNA binding sites for TMEM8B

RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

ADeditom_ID	Position	ENSG	ENST	Transcript name	miRNA ID	Chromosome	Targt	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
ADediting_1465869	chr9_35855463_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-4537	chr9	35855460	35855467	8mer-1a	35855444	35855467	150	-23.19
ADediting_1465869	chr9_35855463_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-4537	chr9	35855460	35855467	8mer-1a	35855444	35855467	150	-23.19
ADediting_1465874	chr9_35858174_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-4537	chr9	35858171	35858178	8mer-1a	35858158	35858178	154	-25.95
ADediting_1465874	chr9_35858174_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-4537	chr9	35858171	35858178	8mer-1a	35858158	35858178	154	-25.95
ADediting_1465876	chr9_35858184_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-6089	chr9	35858182	35858188	7mer-m8	35858166	35858189	165	-37.59
ADediting_1465876	chr9_35858184_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-6089	chr9	35858182	35858188	7mer-m8	35858166	35858189	165	-37.59
ADediting_1465877	chr9_35858198_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-6771-5p	chr9	35858192	35858198	7mer-m8	35858177	35858199	151	-30.09
ADediting_1465877	chr9_35858198_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-6771-5p	chr9	35858192	35858198	7mer-m8	35858177	35858199	151	-30.09
ADediting_1465878	chr9_35858199_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-490-3p	chr9	35858195	35858201	7mer-m8	35858180	35858202	146	-20.27
ADediting_1465878	chr9_35858199_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-490-3p	chr9	35858195	35858201	7mer-m8	35858180	35858202	146	-20.27
ADediting_1465880	chr9_35858233_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-100-5p	chr9	35858229	35858235	7mer-m8	35858216	35858236	160	-20.61
ADediting_1465880	chr9_35858233_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-99a-5p	chr9	35858229	35858235	7mer-m8	35858216	35858236	160	-19.49
ADediting_1465880	chr9_35858233_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-99b-5p	chr9	35858229	35858235	7mer-m8	35858216	35858236	152	-24.4
ADediting_1465880	chr9_35858233_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-100-5p	chr9	35858229	35858235	7mer-m8	35858216	35858236	160	-20.61
ADediting_1465880	chr9_35858233_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-99a-5p	chr9	35858229	35858235	7mer-m8	35858216	35858236	160	-19.49
ADediting_1465880	chr9_35858233_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-99b-5p	chr9	35858229	35858235	7mer-m8	35858216	35858236	152	-24.4
ADediting_1465882	chr9_35858313_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-28-5p	chr9	35858311	35858317	7mer-m8	35858298	35858318	151	-21.08
ADediting_1465882	chr9_35858313_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-3139	chr9	35858311	35858317	7mer-m8	35858296	35858318	161	-25.87
ADediting_1465882	chr9_35858313_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-708-5p	chr9	35858311	35858317	7mer-m8	35858297	35858318	150	-23.04
ADediting_1465882	chr9_35858313_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-28-5p	chr9	35858311	35858317	7mer-m8	35858298	35858318	151	-21.08
ADediting_1465882	chr9_35858313_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-3139	chr9	35858311	35858317	7mer-m8	35858296	35858318	161	-25.87
ADediting_1465882	chr9_35858313_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-708-5p	chr9	35858311	35858317	7mer-m8	35858297	35858318	150	-23.04
ADediting_1465884	chr9_35858352_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-3192-5p	chr9	35858345	35858352	8mer-1a	35858333	35858352	156	-28.56
ADediting_1465884	chr9_35858352_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-326	chr9	35858347	35858353	7mer-m8	35858335	35858354	140	-13.56
ADediting_1465884	chr9_35858352_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-330-5p	chr9	35858347	35858353	7mer-m8	35858333	35858354	140	-18.73
ADediting_1465884	chr9_35858352_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-4314	chr9	35858346	35858352	7mer-m8	35858336	35858353	146	-21.18
ADediting_1465884	chr9_35858352_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-514a-5p	chr9	35858348	35858354	7mer-m8	35858332	35858355	154	-20.73
ADediting_1465884	chr9_35858352_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-3192-5p	chr9	35858345	35858352	8mer-1a	35858333	35858352	156	-28.56
ADediting_1465884	chr9_35858352_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-326	chr9	35858347	35858353	7mer-m8	35858335	35858354	140	-13.56
ADediting_1465884	chr9_35858352_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-330-5p	chr9	35858347	35858353	7mer-m8	35858333	35858354	140	-18.73
ADediting_1465884	chr9_35858352_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-4314	chr9	35858346	35858352	7mer-m8	35858336	35858353	146	-21.18
ADediting_1465884	chr9_35858352_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-514a-5p	chr9	35858348	35858354	7mer-m8	35858332	35858355	154	-20.73
ADediting_1465885	chr9_35858353_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-3189-3p	chr9	35858347	35858353	7mer-m8	35858332	35858354	149	-24.86
ADediting_1465885	chr9_35858353_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-6813-3p	chr9	35858348	35858354	7mer-m8	35858335	35858355	140	-11.55
ADediting_1465885	chr9_35858353_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-3189-3p	chr9	35858347	35858353	7mer-m8	35858332	35858354	149	-24.86
ADediting_1465885	chr9_35858353_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-6813-3p	chr9	35858348	35858354	7mer-m8	35858335	35858355	140	-11.55
ADediting_1465890	chr9_35863069_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-483-3p	chr9	35863062	35863068	7mer-m8	35863049	35863069	159	-26.3
ADediting_1465890	chr9_35863069_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-483-3p	chr9	35863062	35863068	7mer-m8	35863049	35863069	159	-26.3
ADediting_1465891	chr9_35863074_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-3136-3p	chr9	35863070	35863076	7mer-m8	35863057	35863077	149	-16.67
ADediting_1465891	chr9_35863074_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-6724-5p	chr9	35863072	35863078	7mer-m8	35863057	35863079	143	-21.3
ADediting_1465891	chr9_35863074_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-6773-5p	chr9	35863072	35863078	7mer-m8	35863059	35863079	152	-23.04
ADediting_1465891	chr9_35863074_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-7155-3p	chr9	35863070	35863076	7mer-m8	35863059	35863077	154	-21.67
ADediting_1465891	chr9_35863074_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-3136-3p	chr9	35863070	35863076	7mer-m8	35863057	35863077	149	-16.67
ADediting_1465891	chr9_35863074_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-6724-5p	chr9	35863072	35863078	7mer-m8	35863057	35863079	143	-21.3
ADediting_1465891	chr9_35863074_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-6773-5p	chr9	35863072	35863078	7mer-m8	35863059	35863079	152	-23.04
ADediting_1465891	chr9_35863074_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-7155-3p	chr9	35863070	35863076	7mer-m8	35863059	35863077	154	-21.67
ADediting_1465893	chr9_35863093_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-4772-3p	chr9	35863089	35863095	7mer-m8	35863075	35863096	152	-20.69
ADediting_1465893	chr9_35863093_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-4772-3p	chr9	35863089	35863095	7mer-m8	35863075	35863096	152	-20.69
ADediting_1465894	chr9_35863100_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-7705	chr9	35863097	35863103	7mer-m8	35863084	35863104	154	-15.4
ADediting_1465894	chr9_35863100_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-7705	chr9	35863097	35863103	7mer-m8	35863084	35863104	154	-15.4
ADediting_1465895	chr9_35863103_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-27a-3p	chr9	35863099	35863105	7mer-m8	35863083	35863106	144	-15.59
ADediting_1465895	chr9_35863103_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-27b-3p	chr9	35863099	35863105	7mer-m8	35863083	35863106	144	-14.05
ADediting_1465895	chr9_35863103_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-9985	chr9	35863099	35863105	7mer-m8	35863085	35863106	143	-13.02
ADediting_1465895	chr9_35863103_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-27a-3p	chr9	35863099	35863105	7mer-m8	35863083	35863106	144	-15.59
ADediting_1465895	chr9_35863103_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-27b-3p	chr9	35863099	35863105	7mer-m8	35863083	35863106	144	-14.05
ADediting_1465895	chr9_35863103_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-9985	chr9	35863099	35863105	7mer-m8	35863085	35863106	143	-13.02
ADediting_1593636	chr9_35858239_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-6722-5p	chr9	35858234	35858241	8mer-1a	35858220	35858241	148	-20.81
ADediting_1593636	chr9_35858239_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-6722-5p	chr9	35858234	35858241	8mer-1a	35858220	35858241	148	-20.81
ADediting_1593637	chr9_35858255_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-3157-5p	chr9	35858249	35858255	7mer-m8	35858234	35858256	155	-22.88
ADediting_1593637	chr9_35858255_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-34a-3p	chr9	35858251	35858257	7mer-m8	35858236	35858258	149	-8.76
ADediting_1593637	chr9_35858255_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-3157-5p	chr9	35858249	35858255	7mer-m8	35858234	35858256	155	-22.88
ADediting_1593637	chr9_35858255_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-34a-3p	chr9	35858251	35858257	7mer-m8	35858236	35858258	149	-8.76

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

ADeditom_ID	Position	ENSG	ENST	Transcript name	miRNA ID	Chromosome	Targt	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
ADediting_1465869	chr9_35855463_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-3160-3p	chr9	35855460	35855467	8mer-1a	35855446	35855467	150	-19.16
ADediting_1465869	chr9_35855463_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-3160-3p	chr9	35855460	35855467	8mer-1a	35855446	35855467	150	-19.16
ADediting_1465871	chr9_35855577_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-3675-3p	chr9	35855575	35855581	7mer-m8	35855561	35855582	145	-12.58
ADediting_1465871	chr9_35855577_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-3675-3p	chr9	35855575	35855581	7mer-m8	35855561	35855582	145	-12.58
ADediting_1465872	chr9_35858160_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-324-3p	chr9	35858157	35858163	7mer-m8	35858142	35858164	148	-24.15
ADediting_1465872	chr9_35858160_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-4252	chr9	35858158	35858164	7mer-m8	35858145	35858165	149	-21.82
ADediting_1465872	chr9_35858160_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-4793-3p	chr9	35858154	35858160	7mer-m8	35858139	35858161	149	-19.36
ADediting_1465872	chr9_35858160_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-324-3p	chr9	35858157	35858163	7mer-m8	35858142	35858164	148	-24.15
ADediting_1465872	chr9_35858160_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-4252	chr9	35858158	35858164	7mer-m8	35858145	35858165	149	-21.82
ADediting_1465872	chr9_35858160_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-4793-3p	chr9	35858154	35858160	7mer-m8	35858139	35858161	149	-19.36
ADediting_1465874	chr9_35858174_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-3160-3p	chr9	35858171	35858178	8mer-1a	35858157	35858178	150	-19.59
ADediting_1465874	chr9_35858174_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-3160-3p	chr9	35858171	35858178	8mer-1a	35858157	35858178	150	-19.59
ADediting_1465876	chr9_35858184_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-17-3p	chr9	35858178	35858184	7mer-m8	35858164	35858185	150	-16.39
ADediting_1465876	chr9_35858184_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-6884-5p	chr9	35858182	35858188	7mer-m8	35858166	35858189	154	-24.34
ADediting_1465876	chr9_35858184_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-17-3p	chr9	35858178	35858184	7mer-m8	35858164	35858185	150	-16.39
ADediting_1465876	chr9_35858184_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-6884-5p	chr9	35858182	35858188	7mer-m8	35858166	35858189	154	-24.34
ADediting_1465877	chr9_35858198_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-12126	chr9	35858194	35858200	7mer-m8	35858178	35858201	141	-14.39
ADediting_1465877	chr9_35858198_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-3689a-3p	chr9	35858191	35858198	8mer-1a	35858175	35858198	151	-21.7
ADediting_1465877	chr9_35858198_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-6779-5p	chr9	35858191	35858198	8mer-1a	35858178	35858198	148	-21.75
ADediting_1465877	chr9_35858198_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-6780a-5p	chr9	35858191	35858198	8mer-1a	35858174	35858198	155	-26.22
ADediting_1465877	chr9_35858198_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-887-5p	chr9	35858192	35858198	7mer-m8	35858179	35858199	140	-16.67
ADediting_1465877	chr9_35858198_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-12126	chr9	35858194	35858200	7mer-m8	35858178	35858201	141	-14.39
ADediting_1465877	chr9_35858198_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-3689a-3p	chr9	35858191	35858198	8mer-1a	35858175	35858198	151	-21.7
ADediting_1465877	chr9_35858198_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-6779-5p	chr9	35858191	35858198	8mer-1a	35858178	35858198	148	-21.75
ADediting_1465877	chr9_35858198_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-6780a-5p	chr9	35858191	35858198	8mer-1a	35858174	35858198	155	-26.22
ADediting_1465877	chr9_35858198_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-887-5p	chr9	35858192	35858198	7mer-m8	35858179	35858199	140	-16.67
ADediting_1465878	chr9_35858199_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-12126	chr9	35858194	35858200	7mer-m8	35858178	35858201	141	-14.39
ADediting_1465878	chr9_35858199_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-887-5p	chr9	35858192	35858198	7mer-m8	35858179	35858199	140	-16.67
ADediting_1465878	chr9_35858199_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-12126	chr9	35858194	35858200	7mer-m8	35858178	35858201	141	-14.39
ADediting_1465878	chr9_35858199_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-887-5p	chr9	35858192	35858198	7mer-m8	35858179	35858199	140	-16.67
ADediting_1465880	chr9_35858233_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-6804-3p	chr9	35858231	35858238	8mer-1a	35858216	35858238	155	-18.69
ADediting_1465880	chr9_35858233_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-6804-3p	chr9	35858231	35858238	8mer-1a	35858216	35858238	155	-18.69
ADediting_1465883	chr9_35858325_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-3622a-3p	chr9	35858322	35858329	8mer-1a	35858308	35858329	140	-15.99
ADediting_1465883	chr9_35858325_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-3622b-3p	chr9	35858322	35858329	8mer-1a	35858309	35858329	149	-20.31
ADediting_1465883	chr9_35858325_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-4649-3p	chr9	35858319	35858325	7mer-m8	35858306	35858326	147	-18.42
ADediting_1465883	chr9_35858325_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-544b	chr9	35858320	35858326	7mer-m8	35858307	35858327	153	-18.39
ADediting_1465883	chr9_35858325_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-3622a-3p	chr9	35858322	35858329	8mer-1a	35858308	35858329	140	-15.99
ADediting_1465883	chr9_35858325_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-3622b-3p	chr9	35858322	35858329	8mer-1a	35858309	35858329	149	-20.31
ADediting_1465883	chr9_35858325_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-4649-3p	chr9	35858319	35858325	7mer-m8	35858306	35858326	147	-18.42
ADediting_1465883	chr9_35858325_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-544b	chr9	35858320	35858326	7mer-m8	35858307	35858327	153	-18.39
ADediting_1465884	chr9_35858352_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-887-5p	chr9	35858345	35858352	8mer-1a	35858332	35858352	147	-13.82
ADediting_1465884	chr9_35858352_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-887-5p	chr9	35858345	35858352	8mer-1a	35858332	35858352	147	-13.82
ADediting_1465888	chr9_35863015_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-6872-3p	chr9	35863011	35863017	7mer-m8	35862998	35863018	145	-15.75
ADediting_1465888	chr9_35863015_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-6872-3p	chr9	35863011	35863017	7mer-m8	35862998	35863018	145	-15.75
ADediting_1465889	chr9_35863047_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-1237-3p	chr9	35863045	35863051	7mer-m8	35863032	35863052	140	-11.36
ADediting_1465889	chr9_35863047_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-6869-5p	chr9	35863040	35863046	7mer-m8	35863024	35863047	149	-21.29
ADediting_1465889	chr9_35863047_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-1237-3p	chr9	35863045	35863051	7mer-m8	35863032	35863052	140	-11.36
ADediting_1465889	chr9_35863047_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-6869-5p	chr9	35863040	35863046	7mer-m8	35863024	35863047	149	-21.29
ADediting_1465890	chr9_35863069_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-1297	chr9	35863067	35863073	7mer-m8	35863058	35863074	148	-12.41
ADediting_1465890	chr9_35863069_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-26a-5p	chr9	35863067	35863073	7mer-m8	35863053	35863074	152	-14.1
ADediting_1465890	chr9_35863069_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-26b-5p	chr9	35863067	35863073	7mer-m8	35863054	35863074	148	-12.41
ADediting_1465890	chr9_35863069_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-1297	chr9	35863067	35863073	7mer-m8	35863058	35863074	148	-12.41
ADediting_1465890	chr9_35863069_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-26a-5p	chr9	35863067	35863073	7mer-m8	35863053	35863074	152	-14.1
ADediting_1465890	chr9_35863069_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-26b-5p	chr9	35863067	35863073	7mer-m8	35863054	35863074	148	-12.41
ADediting_1465891	chr9_35863074_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-10400-3p	chr9	35863072	35863078	7mer-m8	35863058	35863079	146	-20.37
ADediting_1465891	chr9_35863074_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-1297	chr9	35863067	35863073	7mer-m8	35863058	35863074	148	-12.41
ADediting_1465891	chr9_35863074_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-26a-5p	chr9	35863067	35863073	7mer-m8	35863053	35863074	152	-14.1
ADediting_1465891	chr9_35863074_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-26b-5p	chr9	35863067	35863073	7mer-m8	35863054	35863074	148	-12.41
ADediting_1465891	chr9_35863074_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-4437	chr9	35863071	35863078	8mer-1a	35863059	35863078	152	-21.55
ADediting_1465891	chr9_35863074_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-4674	chr9	35863072	35863078	7mer-m8	35863058	35863079	150	-25.1
ADediting_1465891	chr9_35863074_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-10400-3p	chr9	35863072	35863078	7mer-m8	35863058	35863079	146	-20.37
ADediting_1465891	chr9_35863074_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-1297	chr9	35863067	35863073	7mer-m8	35863058	35863074	148	-12.41
ADediting_1465891	chr9_35863074_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-26a-5p	chr9	35863067	35863073	7mer-m8	35863053	35863074	152	-14.1
ADediting_1465891	chr9_35863074_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-26b-5p	chr9	35863067	35863073	7mer-m8	35863054	35863074	148	-12.41
ADediting_1465891	chr9_35863074_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-4437	chr9	35863071	35863078	8mer-1a	35863059	35863078	152	-21.55
ADediting_1465891	chr9_35863074_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-4674	chr9	35863072	35863078	7mer-m8	35863058	35863079	150	-25.1
ADediting_1465892	chr9_35863079_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-10400-3p	chr9	35863072	35863078	7mer-m8	35863058	35863079	146	-20.37
ADediting_1465892	chr9_35863079_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-1343-3p	chr9	35863075	35863081	7mer-m8	35863060	35863082	150	-25.22
ADediting_1465892	chr9_35863079_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-4674	chr9	35863072	35863078	7mer-m8	35863058	35863079	150	-25.1
ADediting_1465892	chr9_35863079_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-939-3p	chr9	35863074	35863081	8mer-1a	35863059	35863081	152	-27.58
ADediting_1465892	chr9_35863079_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-10400-3p	chr9	35863072	35863078	7mer-m8	35863058	35863079	146	-20.37
ADediting_1465892	chr9_35863079_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-1343-3p	chr9	35863075	35863081	7mer-m8	35863060	35863082	150	-25.22
ADediting_1465892	chr9_35863079_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-4674	chr9	35863072	35863078	7mer-m8	35863058	35863079	150	-25.1
ADediting_1465892	chr9_35863079_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-939-3p	chr9	35863074	35863081	8mer-1a	35863059	35863081	152	-27.58
ADediting_1593636	chr9_35858239_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-500a-3p	chr9	35858232	35858238	7mer-m8	35858218	35858239	145	-17.16
ADediting_1593636	chr9_35858239_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-500a-3p	chr9	35858232	35858238	7mer-m8	35858218	35858239	145	-17.16

RNA A-to-I editing in lncRNA gained miRNA binding sites.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

ADeditom_ID

Position

ENSG

ENST

Transcript name

miRNA ID

Chromosome

Targt

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

ADeditom_ID	Position	ENSG	ENST	Transcript name	miRNA ID	Chromosome	Targt	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
ADediting_1337757	chr7_5495852_-	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-589-3p	chr9	35855191	35855197	7mer-m8	35855175	35855198	159	-17.78
ADediting_1337757	chr7_5495852_-	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-589-3p	chr9	35863749	35863756	8mer-1a	35863733	35863756	144	-23.61
ADediting_1337757	chr7_5495852_-	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-589-3p	chr9	35855191	35855197	7mer-m8	35855175	35855198	159	-17.78
ADediting_1337757	chr7_5495852_-	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-589-3p	chr9	35863749	35863756	8mer-1a	35863733	35863756	144	-23.61
ADediting_1337758	chr7_5495892_-	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-589-5p	chr9	35863525	35863532	8mer-1a	35863511	35863532	165	-27.89
ADediting_1337758	chr7_5495892_-	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-589-5p	chr9	35864886	35864892	7mer-m8	35864872	35864893	152	-21.37
ADediting_1337758	chr7_5495892_-	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-589-5p	chr9	35863525	35863532	8mer-1a	35863511	35863532	165	-27.89
ADediting_1337758	chr7_5495892_-	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-589-5p	chr9	35864886	35864892	7mer-m8	35864872	35864893	152	-21.37
ADediting_1535953	chr14_101045971_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-381-3p	chr9	35857065	35857071	7mer-m8	35857048	35857072	162	-25.92
ADediting_1535953	chr14_101045971_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-381-3p	chr9	35857065	35857071	7mer-m8	35857048	35857072	162	-25.92
ADediting_1556067	chr19_40282625_-	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-641	chr9	35860692	35860699	8mer-1a	35860676	35860699	140	-10.49
ADediting_1556067	chr19_40282625_-	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-641	chr9	35860692	35860699	8mer-1a	35860676	35860699	140	-10.49
ADediting_291761	chr11_93733708_-	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-1304-3p	chr9	35859138	35859144	7mer-m8	35859125	35859145	154	-25.63
ADediting_291761	chr11_93733708_-	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-1304-3p	chr9	35859138	35859144	7mer-m8	35859125	35859145	154	-25.63
ADediting_843620	chr2_207754818_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-4775	chr9	35857542	35857548	7mer-m8	35857528	35857549	151	-15.22
ADediting_843620	chr2_207754818_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-4775	chr9	35863195	35863202	8mer-1a	35863181	35863202	143	-9.43
ADediting_843620	chr2_207754818_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-4775	chr9	35865463	35865469	7mer-m8	35865449	35865470	163	-12
ADediting_843620	chr2_207754818_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-4775	chr9	35857542	35857548	7mer-m8	35857528	35857549	151	-15.22
ADediting_843620	chr2_207754818_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-4775	chr9	35863195	35863202	8mer-1a	35863181	35863202	143	-9.43
ADediting_843620	chr2_207754818_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-4775	chr9	35865463	35865469	7mer-m8	35865449	35865470	163	-12
ADediting_98288	chr1_32086990_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-5585-3p	chr9	35862693	35862699	7mer-m8	35862679	35862700	146	-14.78
ADediting_98288	chr1_32086990_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-5585-3p	chr9	35862693	35862699	7mer-m8	35862679	35862700	146	-14.78
ADediting_98289	chr1_32086992_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-5585-3p	chr9	35858621	35858627	7mer-m8	35858605	35858628	164	-22.79
ADediting_98289	chr1_32086992_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-5585-3p	chr9	35860652	35860658	7mer-m8	35860637	35860659	149	-10.97
ADediting_98289	chr1_32086992_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-5585-3p	chr9	35858621	35858627	7mer-m8	35858605	35858628	164	-22.79
ADediting_98289	chr1_32086992_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-5585-3p	chr9	35860652	35860658	7mer-m8	35860637	35860659	149	-10.97

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

ADeditom_ID	Position	ENSG	ENST	Transcript name	miRNA ID	Chromosome	Targt	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
ADediting_1337757	chr7_5495852_-	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-589-3p	chr9	35857164	35857171	8mer-1a	35857148	35857171	145	-15.54
ADediting_1337757	chr7_5495852_-	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-589-3p	chr9	35861347	35861353	7mer-m8	35861331	35861354	145	-18.3
ADediting_1337757	chr7_5495852_-	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-589-3p	chr9	35857164	35857171	8mer-1a	35857148	35857171	145	-15.54
ADediting_1337757	chr7_5495852_-	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-589-3p	chr9	35861347	35861353	7mer-m8	35861331	35861354	145	-18.3
ADediting_1337758	chr7_5495892_-	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-589-5p	chr9	35855103	35855109	7mer-m8	35855087	35855110	146	-17.62
ADediting_1337758	chr7_5495892_-	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-589-5p	chr9	35863659	35863666	8mer-1a	35863645	35863666	140	-20
ADediting_1337758	chr7_5495892_-	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-589-5p	chr9	35855103	35855109	7mer-m8	35855087	35855110	146	-17.62
ADediting_1337758	chr7_5495892_-	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-589-5p	chr9	35863659	35863666	8mer-1a	35863645	35863666	140	-20
ADediting_1471003	chr9_63819626_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-4477b	chr9	35860634	35860640	7mer-m8	35860620	35860641	146	-10.71
ADediting_1471003	chr9_63819626_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-4477b	chr9	35860634	35860640	7mer-m8	35860620	35860641	146	-10.71
ADediting_1471004	chr9_63819627_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-4477b	chr9	35860634	35860640	7mer-m8	35860620	35860641	146	-10.71
ADediting_1471004	chr9_63819627_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-4477b	chr9	35860634	35860640	7mer-m8	35860620	35860641	146	-10.71
ADediting_1535953	chr14_101045971_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-381-3p	chr9	35856234	35856241	8mer-1a	35856217	35856241	146	-11.87
ADediting_1535953	chr14_101045971_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-381-3p	chr9	35862844	35862851	8mer-1a	35862829	35862851	151	-14.38
ADediting_1535953	chr14_101045971_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-381-3p	chr9	35856234	35856241	8mer-1a	35856217	35856241	146	-11.87
ADediting_1535953	chr14_101045971_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-381-3p	chr9	35862844	35862851	8mer-1a	35862829	35862851	151	-14.38
ADediting_1535954	chr14_101045974_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-381-3p	chr9	35856234	35856241	8mer-1a	35856217	35856241	146	-11.87
ADediting_1535954	chr14_101045974_+	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-381-3p	chr9	35862844	35862851	8mer-1a	35862829	35862851	151	-14.38
ADediting_1535954	chr14_101045974_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-381-3p	chr9	35856234	35856241	8mer-1a	35856217	35856241	146	-11.87
ADediting_1535954	chr14_101045974_+	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-381-3p	chr9	35862844	35862851	8mer-1a	35862829	35862851	151	-14.38
ADediting_1556067	chr19_40282625_-	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-641	chr9	35861023	35861030	8mer-1a	35861007	35861030	140	-10.19
ADediting_1556067	chr19_40282625_-	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-641	chr9	35861023	35861030	8mer-1a	35861007	35861030	140	-10.19
ADediting_1631458	chr19_40282624_-	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-641	chr9	35861023	35861030	8mer-1a	35861007	35861030	140	-10.19
ADediting_1631458	chr19_40282624_-	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-641	chr9	35861023	35861030	8mer-1a	35861007	35861030	140	-10.19
ADediting_291761	chr11_93733708_-	ENSG00000137103.20	ENST00000377988.6	TMEM8B-201	hsa-miR-1304-3p	chr9	35854710	35854717	8mer-1a	35854696	35854717	140	-14.24
ADediting_291761	chr11_93733708_-	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-1304-3p	chr9	35854710	35854717	8mer-1a	35854696	35854717	140	-14.24
ADediting_291761	chr11_93733708_-	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-1304-3p	chr9	35855853	35855859	7mer-1a	35855849	35855869	142	-19.61
ADediting_291761	chr11_93733708_-	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-1304-3p	chr9	35855862	35855868	7mer-m8	35855849	35855869	142	-19.61
ADediting_291761	chr11_93733708_-	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-1304-3p	chr9	35856052	35856058	7mer-m8	35856037	35856059	143	-22.41
ADediting_291761	chr11_93733708_-	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-1304-3p	chr9	35859513	35859519	7mer-m8	35859498	35859520	151	-16.55
ADediting_291761	chr11_93733708_-	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-1304-3p	chr9	35864642	35864648	7mer-m8	35864628	35864649	140	-13.19
ADediting_291761	chr11_93733708_-	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-1304-3p	chr9	35854710	35854717	8mer-1a	35854696	35854717	140	-14.24
ADediting_291761	chr11_93733708_-	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-1304-3p	chr9	35855853	35855859	7mer-1a	35855849	35855869	142	-19.61
ADediting_291761	chr11_93733708_-	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-1304-3p	chr9	35855862	35855868	7mer-m8	35855849	35855869	142	-19.61
ADediting_291761	chr11_93733708_-	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-1304-3p	chr9	35856052	35856058	7mer-m8	35856037	35856059	143	-22.41
ADediting_291761	chr11_93733708_-	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-1304-3p	chr9	35859513	35859519	7mer-m8	35859498	35859520	151	-16.55
ADediting_291761	chr11_93733708_-	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-1304-3p	chr9	35864642	35864648	7mer-m8	35864628	35864649	140	-13.19
ADediting_291761	chr11_93733708_-	ENSG00000137103.20	ENST00000650015.1	TMEM8B-209	hsa-miR-1304-3p	chr9	35854710	35854717	8mer-1a	35854696	35854717	140	-14.24
ADediting_496066	chr15_66496985_-	ENSG00000137103.20	ENST00000377991.9	TMEM8B-202	hsa-miR-4512	chr9	35862139	35862145	7mer-m8	35862126	35862146	152	-20.53
ADediting_496066	chr15_66496985_-	ENSG00000137103.20	ENST00000643932.2	TMEM8B-208	hsa-miR-4512	chr9	35862139	35862145	7mer-m8	35862126	35862146	152	-20.53

Differentially expressed gene-miRNA network

Top

The effects of the RNA editing to the stability of the RNA structures for TMEM8B

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000643932.2	protein_coding
ENST00000377991.9	protein_coding

RNA A-to-I editing in miRNA.

ADeditom_ID

ENST

mir_ID

Editing_Information

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

RNA A-to-I editing in mRNA.

ADeditom_ID	ENST	Editing_Information	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
ADediting_1465869	ENST00000643932.2	chr9_35855463_+	4618	-5543.80	-5543.70	-5581.40
ADediting_1465870	ENST00000643932.2	chr9_35855574_+	4729	-5543.70	-5543.70	-5581.40
ADediting_1465871	ENST00000643932.2	chr9_35855577_+	4732	-5543.90	-5543.70	-5581.40
ADediting_1465872	ENST00000643932.2	chr9_35858160_+	7315	-5543.00	-5543.70	-5581.40
ADediting_1465873	ENST00000643932.2	chr9_35858169_+	7324	-5544.00	-5543.70	-5581.40
ADediting_1465874	ENST00000643932.2	chr9_35858174_+	7329	-5543.70	-5543.70	-5581.40
ADediting_1465875	ENST00000643932.2	chr9_35858179_+	7334	-5543.30	-5543.70	-5581.40
ADediting_1465876	ENST00000643932.2	chr9_35858184_+	7339	-5543.00	-5543.70	-5581.40
ADediting_1465877	ENST00000643932.2	chr9_35858198_+	7353	-5544.00	-5543.70	-5581.40
ADediting_1465878	ENST00000643932.2	chr9_35858199_+	7354	-5546.00	-5543.70	-5581.40
ADediting_1465879	ENST00000643932.2	chr9_35858231_+	7386	-5544.20	-5543.70	-5581.40
ADediting_1465880	ENST00000643932.2	chr9_35858233_+	7388	-5543.00	-5543.70	-5581.40
ADediting_1593636	ENST00000643932.2	chr9_35858239_+	7394	-5543.70	-5543.70	-5581.40
ADediting_1593637	ENST00000643932.2	chr9_35858255_+	7410	-5543.90	-5543.70	-5581.40
ADediting_1465881	ENST00000643932.2	chr9_35858271_+	7426	-5545.20	-5543.70	-5581.40
ADediting_1465882	ENST00000643932.2	chr9_35858313_+	7468	-5543.70	-5543.70	-5581.40
ADediting_1465883	ENST00000643932.2	chr9_35858325_+	7480	-5542.90	-5543.70	-5581.40
ADediting_1465884	ENST00000643932.2	chr9_35858352_+	7507	-5547.10	-5543.70	-5581.40
ADediting_1465885	ENST00000643932.2	chr9_35858353_+	7508	-5544.40	-5543.70	-5581.40
ADediting_1465886	ENST00000643932.2	chr9_35858365_+	7520	-5542.70	-5543.70	-5581.40
ADediting_1465887	ENST00000643932.2	chr9_35858383_+	7538	-5547.50	-5543.70	-5581.40
ADediting_1465888	ENST00000643932.2	chr9_35863015_+	12170	-5547.90	-5543.70	-5581.40
ADediting_1465889	ENST00000643932.2	chr9_35863047_+	12202	-5547.20	-5543.70	-5581.40
ADediting_1465890	ENST00000643932.2	chr9_35863069_+	12224	-5543.40	-5543.70	-5581.40
ADediting_1465891	ENST00000643932.2	chr9_35863074_+	12229	-5542.80	-5543.70	-5581.40
ADediting_1465892	ENST00000643932.2	chr9_35863079_+	12234	-5543.00	-5543.70	-5581.40
ADediting_1465893	ENST00000643932.2	chr9_35863093_+	12248	-5549.20	-5543.70	-5581.40
ADediting_1593638	ENST00000643932.2	chr9_35863095_+	12250	-5543.00	-5543.70	-5581.40
ADediting_1465894	ENST00000643932.2	chr9_35863100_+	12255	-5550.40	-5543.70	-5581.40
ADediting_1465895	ENST00000643932.2	chr9_35863103_+	12258	-5547.10	-5543.70	-5581.40
ADediting_1465869	ENST00000377991.9	chr9_35855463_+	4057	-5301.80	-5301.70	-5339.40
ADediting_1465870	ENST00000377991.9	chr9_35855574_+	4168	-5301.70	-5301.70	-5339.40
ADediting_1465871	ENST00000377991.9	chr9_35855577_+	4171	-5301.90	-5301.70	-5339.40
ADediting_1465872	ENST00000377991.9	chr9_35858160_+	6754	-5301.00	-5301.70	-5339.40
ADediting_1465873	ENST00000377991.9	chr9_35858169_+	6763	-5302.00	-5301.70	-5339.40
ADediting_1465874	ENST00000377991.9	chr9_35858174_+	6768	-5301.70	-5301.70	-5339.40
ADediting_1465875	ENST00000377991.9	chr9_35858179_+	6773	-5301.30	-5301.70	-5339.40
ADediting_1465876	ENST00000377991.9	chr9_35858184_+	6778	-5301.00	-5301.70	-5339.40
ADediting_1465877	ENST00000377991.9	chr9_35858198_+	6792	-5302.00	-5301.70	-5339.40
ADediting_1465878	ENST00000377991.9	chr9_35858199_+	6793	-5304.00	-5301.70	-5339.40
ADediting_1465879	ENST00000377991.9	chr9_35858231_+	6825	-5302.20	-5301.70	-5339.40
ADediting_1465880	ENST00000377991.9	chr9_35858233_+	6827	-5301.00	-5301.70	-5339.40
ADediting_1593636	ENST00000377991.9	chr9_35858239_+	6833	-5301.70	-5301.70	-5339.40
ADediting_1593637	ENST00000377991.9	chr9_35858255_+	6849	-5301.90	-5301.70	-5339.40
ADediting_1465881	ENST00000377991.9	chr9_35858271_+	6865	-5303.20	-5301.70	-5339.40
ADediting_1465882	ENST00000377991.9	chr9_35858313_+	6907	-5301.70	-5301.70	-5339.40
ADediting_1465883	ENST00000377991.9	chr9_35858325_+	6919	-5300.90	-5301.70	-5339.40
ADediting_1465884	ENST00000377991.9	chr9_35858352_+	6946	-5305.10	-5301.70	-5339.40
ADediting_1465885	ENST00000377991.9	chr9_35858353_+	6947	-5302.40	-5301.70	-5339.40
ADediting_1465886	ENST00000377991.9	chr9_35858365_+	6959	-5300.70	-5301.70	-5339.40
ADediting_1465887	ENST00000377991.9	chr9_35858383_+	6977	-5305.50	-5301.70	-5339.40
ADediting_1465888	ENST00000377991.9	chr9_35863015_+	11609	-5305.90	-5301.70	-5339.40
ADediting_1465889	ENST00000377991.9	chr9_35863047_+	11641	-5305.20	-5301.70	-5339.40
ADediting_1465890	ENST00000377991.9	chr9_35863069_+	11663	-5301.40	-5301.70	-5339.40
ADediting_1465891	ENST00000377991.9	chr9_35863074_+	11668	-5300.80	-5301.70	-5339.40
ADediting_1465892	ENST00000377991.9	chr9_35863079_+	11673	-5301.00	-5301.70	-5339.40
ADediting_1465893	ENST00000377991.9	chr9_35863093_+	11687	-5307.20	-5301.70	-5339.40
ADediting_1593638	ENST00000377991.9	chr9_35863095_+	11689	-5301.00	-5301.70	-5339.40
ADediting_1465894	ENST00000377991.9	chr9_35863100_+	11694	-5308.40	-5301.70	-5339.40
ADediting_1465895	ENST00000377991.9	chr9_35863103_+	11697	-5305.10	-5301.70	-5339.40

RNA A-to-I editing in lncRNA.

ADeditom_ID

ENST

Editing_Information

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

Top

Relation with ADAR for TMEM8B

Correlation between ADAR gene expression and RNA editing frequency

Tissue	ADeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
TCX	ADediting_1465874	chr9_35858174_+	9.01420711585909e-06	0.353662220671147	0.000217612694181042	0.297533280415974	0.483119798096155	0.0576953092456721
CER	ADediting_1465876	chr9_35858184_+	4.06275049604245e-07	0.399613632115518	5.0807955793209e-10	0.480081231361705	0.413082418441479	0.0673159990691869
TCX	ADediting_1465876	chr9_35858184_+	6.41925489924023e-06	0.359053181695664	6.46004162273598e-06	0.358953500852648	0.144758609791087	-0.119642211923586
CER	ADediting_1465877	chr9_35858198_+	1.89246296311677e-05	0.341530427542932	1.90482752790353e-09	0.465742346856451	0.0924486307036525	0.137881817033308
TCX	ADediting_1465877	chr9_35858198_+	6.6460608765377e-06	0.358506305417214	1.95254684524729e-05	0.341007959737091	0.637480862300508	0.038785243120452
CER	ADediting_1465878	chr9_35858199_+	3.26605993704049e-05	0.332270628525473	2.11629891875812e-07	0.408455037930545	0.436214543144229	0.0640429904338355
TCX	ADediting_1465878	chr9_35858199_+	1.28589848090809e-05	0.347913872855784	2.84099859407037e-07	0.404494421696529	0.296960816157475	-0.0857186103505765
TCX	ADediting_1465881	chr9_35858271_+	3.64112058322392e-05	0.330390119322746	0.000810493606795852	0.270603313611279	0.891179118806597	-0.0112645609851564
CER	ADediting_1465883	chr9_35858325_+	2.1676411860008e-06	0.375665085343558	8.00711256537385e-06	0.355554624792115	0.0682166752674131	0.149307384984496
TCX	ADediting_1465883	chr9_35858325_+	1.00524159803402e-06	0.386891005819478	3.10409713441007e-08	0.433092554590014	0.223303650999021	-0.100019330769547
DLPFC	ADediting_1465888	chr9_35863015_+	3.95686169447191e-08	0.305703135948828	0.00839113511316981	0.14947166463264	0.0420296043246989	0.115559216130298
DLPFC	ADediting_1465892	chr9_35863079_+	1.3568696729646e-09	0.335539510112825	1.71817859793426e-05	0.241500904502676	0.299053067431438	0.0591682538311791
CER	ADediting_1465892	chr9_35863079_+	7.74425743816403e-07	0.390609248144646	1.38485621217278e-09	0.469262451433733	0.0149855053657605	0.198313537517376
TCX	ADediting_1465892	chr9_35863079_+	5.05487507972502e-05	0.324639328147438	3.4385301419482e-12	0.528974759924649	0.0263929663627111	-0.181304761882566
DLPFC	ADediting_1465893	chr9_35863093_+	7.60747023830578e-13	0.392269269256825	8.46316179604865e-08	0.298496763736397	0.31149219773837	0.0576682997795202
CER	ADediting_1465893	chr9_35863093_+	1.8346368230313e-08	0.439512998863918	2.25828272823046e-09	0.463846411709413	0.000307216422576334	0.290725675096056
TCX	ADediting_1465893	chr9_35863093_+	2.66663969332513e-07	0.405350578231558	6.73790674525748e-06	0.358289858518757	0.739391980954611	0.0273854599390618

Correlation between ADAR gene expression and this gene's expression

Tissue	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
DLPFC	3.91076698381966e-63	0.774181271873705	1.43075597609269e-62	0.771994392561056	3.39980859062619e-15	0.427373332515698
AC	6.64568602579211e-47	0.752611107151744	1.1855358163519e-37	0.696759403367549	1.38526917499825e-29	0.634634984711027
PCC	2.84500420035691e-50	0.832117341751167	1.7140716210627e-47	0.819095368514251	5.78309083932237e-07	0.35231481218602
CER	3.36090179061534e-14	0.568197522447313	2.07581694017291e-05	0.339981878071515	0.0625616778125916	0.152440961455725
TCX	3.44129908817419e-33	0.789522694931045	6.41561201546127e-18	0.629320980303299	0.104473346900809	0.133084700641474
FP	1.50920897112723e-16	0.567282065995279	9.60472666296293e-06	0.324974755747818	9.43392282193338e-14	0.52059605887874
IFG	8.91690572111321e-07	0.810745074922215	2.09715647649113e-07	0.834951968513731	0.0508094713854359	0.394794757583591
PG	1.04461082336098e-05	0.316954649556627	0.000170931427800868	0.272199930788652	0.0236998652856022	0.165822890285172
STG	6.79349408280858e-15	0.724412364927517	5.65399276840226e-07	0.514165637342942	0.000673843291743541	0.363633812706369

Top

Relation with AD stages for TMEM8B

Correlation between AD stages and RNA editing frequency

Tissue	ADeditomID	position	P-val	Coeff.
CER	ADediting_1465874	chr9_35858174_+	0.000299110879289622	0.341413156346665
CER	ADediting_1465877	chr9_35858198_+	0.000444670759033604	0.332163630779933
CER	ADediting_1465892	chr9_35863079_+	0.000237681414281111	0.346647187109313
IFG	ADediting_1465893	chr9_35863093_+	0.0147669422841708	0.48168062438182

Correlation between AD stages and this gene's expression

Tissue	P-val	Coeff.
TCX	5.70916872484905e-05	0.380592055347507

Top

RelatedDrugs for TMEM8B

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

RelatedDiseases for TMEM8B

Diseases associated with this gene.
(DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

Home

Download

Statistics

Landscape

Help

Contact

Gene summary for TMEM8B

RNA A-to-I events for TMEM8B

RNA editing positional annotations for TMEM8B using Annovar

RNA A-to-I editing events in the alternative splicing sites for TMEM8B

Differntial gene expression between RNA A-to-I edited versus non-edited samples for TMEM8B

Protein coding region RNA A-to-I editings for TMEM8B

The effects of the RNA editing to the miRNA binding sites for TMEM8B

The effects of the RNA editing to the stability of the RNA structures for TMEM8B

Relation with ADAR for TMEM8B

Relation with AD stages for TMEM8B

RelatedDrugs for TMEM8B

RelatedDiseases for TMEM8B

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited versus non-edited samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with AD stages
	Related drugs with this gene
	Related diseases with this gene