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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for AZIN1 |
 Gene summary |
| Gene information | Gene symbol | AZIN1 | Gene ID | 51582 |
| Gene name | antizyme inhibitor 1 | |
| Synonyms | AZI|AZI1|AZIA1|OAZI|OAZIN|ODC1L | |
| Cytomap | 8q22.3 | |
| Type of gene | protein-coding | |
| Description | antizyme inhibitor 1ornithine decarboxylase antizyme inhibitor | |
| Modification date | 20200313 | |
| UniProtAcc | O14977, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| AZIN1 | GO:0042177 | negative regulation of protein catabolic process | 17900240 |
| AZIN1 | GO:1902269 | positive regulation of polyamine transmembrane transport | 18508777 |
Top |
RNA A-to-I events for AZIN1 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_1379315(102829408, -), ADediting_1379316(102830135, -), ADediting_1379317(102830258, -), ADediting_1379318(102830264, -), ADediting_1379319(102830278, -), ADediting_1379320(102830294, -), ADediting_1379321(102832709, -), ADediting_1379322(102832749, -), ADediting_1379323(102832769, -), ADediting_1379324(102832778, -), ADediting_1379325(102832779, -), ADediting_1379326(102832785, -), ADediting_1379327(102832805, -), ADediting_1379328(102833837, -), ADediting_1379329(102837039, -), ADediting_1379330(102842051, -), ADediting_1379331(102847330, -), ADediting_1379332(102851463, -), ADediting_1379333(102851473, -), ADediting_1379334(102851514, -), ADediting_1379335(102851623, -), ADediting_1379336(102851630, -), ADediting_1379337(102851637, -), ADediting_1379338(102851643, -), ADediting_1379339(102852489, -), ADediting_1379340(102852557, -), ADediting_1379341(102853242, -), ADediting_1379342(102853248, -), ADediting_1379343(102853254, -), ADediting_1379344(102853260, -), ADediting_1379345(102853311, -), ADediting_1379346(102853318, -), ADediting_1379347(102853337, -), ADediting_1379348(102853340, -), ADediting_1379349(102853370, -), ADediting_1379350(102853380, -), ADediting_1379351(102853433, -), ADediting_1379352(102853439, -), ADediting_1379353(102853450, -), ADediting_1379354(102853464, -), ADediting_1379355(102853471, -), ADediting_1379356(102854009, -), ADediting_1379357(102854010, -), ADediting_1379358(102854018, -), ADediting_1379359(102854067, -), ADediting_1379360(102854072, -), ADediting_1379361(102854073, -), ADediting_1379362(102854170, -), ADediting_1379363(102854181, -), ADediting_1379364(102854212, -), ADediting_1379365(102854218, -), ADediting_1379366(102854342, -), ADediting_1379367(102854344, -), ADediting_1379368(102854355, -), ADediting_1379369(102854356, -), ADediting_1379370(102854408, -), ADediting_1379371(102859714, -), ADediting_1379372(102861313, -), ADediting_1379373(102861324, -), ADediting_1379374(102861325, -), ADediting_1379375(102861333, -), ADediting_1379376(102861365, -), ADediting_1379377(102861366, -), ADediting_1379378(102861392, -), ADediting_1379379(102861403, -), ADediting_1379380(102861405, -), ADediting_1379381(102861407, -), ADediting_1379382(102861410, -), ADediting_1379383(102861494, -), ADediting_1379384(102861495, -), ADediting_1379385(102861783, -), ADediting_1379386(102861868, -), ADediting_1379387(102861869, -), ADediting_1379388(102861873, -), ADediting_1379389(102861914, -), ADediting_1379390(102861936, -), ADediting_1379391(102861953, -), ADediting_1589370(102830212, -), ADediting_1589371(102830223, -), ADediting_1589372(102830361, -), ADediting_1589373(102840491, -), ADediting_1667788(102832869, -), ADediting_1667789(102853323, -), ADediting_1667790(102853984, -), ADediting_1667791(102854419, -), ADediting_1667792(102861336, -), ADediting_1667793(102861401, -), ADediting_1667794(102861786, -), ADediting_1667795(102861870, -), ADediting_1667796(102861954, -), |
Top |
RNA editing positional annotations for AZIN1 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| ADediting_1379315 | chr8_102829408_- | nonsynonymous SNV | ENST00000337198.10 | c.A1099G | p.S367G | 0.596 | 0.001 | -0.25 |
| ADediting_1379315 | chr8_102829408_- | nonsynonymous SNV | ENST00000347770.8 | c.A1099G | p.S367G | 0.596 | 0.001 | -0.25 |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_1379315 | chr8_102829408_- | exonic |
| ADediting_1379316 | chr8_102830135_- | intronic |
| ADediting_1379317 | chr8_102830258_- | intronic |
| ADediting_1379318 | chr8_102830264_- | intronic |
| ADediting_1379319 | chr8_102830278_- | intronic |
| ADediting_1379320 | chr8_102830294_- | intronic |
| ADediting_1379321 | chr8_102832709_- | intronic |
| ADediting_1379322 | chr8_102832749_- | intronic |
| ADediting_1379323 | chr8_102832769_- | intronic |
| ADediting_1379324 | chr8_102832778_- | intronic |
| ADediting_1379325 | chr8_102832779_- | intronic |
| ADediting_1379326 | chr8_102832785_- | intronic |
| ADediting_1379327 | chr8_102832805_- | intronic |
| ADediting_1379328 | chr8_102833837_- | intronic |
| ADediting_1379329 | chr8_102837039_- | intronic |
| ADediting_1379330 | chr8_102842051_- | intronic |
| ADediting_1379331 | chr8_102847330_- | intronic |
| ADediting_1379332 | chr8_102851463_- | intronic |
| ADediting_1379333 | chr8_102851473_- | intronic |
| ADediting_1379334 | chr8_102851514_- | intronic |
| ADediting_1379335 | chr8_102851623_- | intronic |
| ADediting_1379336 | chr8_102851630_- | intronic |
| ADediting_1379337 | chr8_102851637_- | intronic |
| ADediting_1379338 | chr8_102851643_- | intronic |
| ADediting_1379339 | chr8_102852489_- | intronic |
| ADediting_1379340 | chr8_102852557_- | intronic |
| ADediting_1379341 | chr8_102853242_- | intronic |
| ADediting_1379342 | chr8_102853248_- | intronic |
| ADediting_1379343 | chr8_102853254_- | intronic |
| ADediting_1379344 | chr8_102853260_- | intronic |
| ADediting_1379345 | chr8_102853311_- | intronic |
| ADediting_1379346 | chr8_102853318_- | intronic |
| ADediting_1379347 | chr8_102853337_- | intronic |
| ADediting_1379348 | chr8_102853340_- | intronic |
| ADediting_1379349 | chr8_102853370_- | intronic |
| ADediting_1379350 | chr8_102853380_- | intronic |
| ADediting_1379351 | chr8_102853433_- | intronic |
| ADediting_1379352 | chr8_102853439_- | intronic |
| ADediting_1379353 | chr8_102853450_- | intronic |
| ADediting_1379354 | chr8_102853464_- | intronic |
| ADediting_1379355 | chr8_102853471_- | intronic |
| ADediting_1379356 | chr8_102854009_- | intronic |
| ADediting_1379357 | chr8_102854010_- | intronic |
| ADediting_1379358 | chr8_102854018_- | intronic |
| ADediting_1379359 | chr8_102854067_- | intronic |
| ADediting_1379360 | chr8_102854072_- | intronic |
| ADediting_1379361 | chr8_102854073_- | intronic |
| ADediting_1379362 | chr8_102854170_- | intronic |
| ADediting_1379363 | chr8_102854181_- | intronic |
| ADediting_1379364 | chr8_102854212_- | intronic |
| ADediting_1379365 | chr8_102854218_- | intronic |
| ADediting_1379366 | chr8_102854342_- | intronic |
| ADediting_1379367 | chr8_102854344_- | intronic |
| ADediting_1379368 | chr8_102854355_- | intronic |
| ADediting_1379369 | chr8_102854356_- | intronic |
| ADediting_1379370 | chr8_102854408_- | intronic |
| ADediting_1379371 | chr8_102859714_- | intronic |
| ADediting_1379372 | chr8_102861313_- | intronic |
| ADediting_1379373 | chr8_102861324_- | intronic |
| ADediting_1379374 | chr8_102861325_- | intronic |
| ADediting_1379375 | chr8_102861333_- | intronic |
| ADediting_1379376 | chr8_102861365_- | intronic |
| ADediting_1379377 | chr8_102861366_- | intronic |
| ADediting_1379378 | chr8_102861392_- | intronic |
| ADediting_1379379 | chr8_102861403_- | intronic |
| ADediting_1379380 | chr8_102861405_- | intronic |
| ADediting_1379381 | chr8_102861407_- | intronic |
| ADediting_1379382 | chr8_102861410_- | intronic |
| ADediting_1379383 | chr8_102861494_- | intronic |
| ADediting_1379384 | chr8_102861495_- | intronic |
| ADediting_1379385 | chr8_102861783_- | intronic |
| ADediting_1379386 | chr8_102861868_- | intronic |
| ADediting_1379387 | chr8_102861869_- | intronic |
| ADediting_1379388 | chr8_102861873_- | intronic |
| ADediting_1379389 | chr8_102861914_- | intronic |
| ADediting_1379390 | chr8_102861936_- | intronic |
| ADediting_1379391 | chr8_102861953_- | intronic |
| ADediting_1589370 | chr8_102830212_- | intronic |
| ADediting_1589371 | chr8_102830223_- | intronic |
| ADediting_1589372 | chr8_102830361_- | intronic |
| ADediting_1589373 | chr8_102840491_- | intronic |
| ADediting_1667788 | chr8_102832869_- | intronic |
| ADediting_1667789 | chr8_102853323_- | intronic |
| ADediting_1667790 | chr8_102853984_- | intronic |
| ADediting_1667791 | chr8_102854419_- | intronic |
| ADediting_1667792 | chr8_102861336_- | intronic |
| ADediting_1667793 | chr8_102861401_- | intronic |
| ADediting_1667794 | chr8_102861786_- | intronic |
| ADediting_1667795 | chr8_102861870_- | intronic |
| ADediting_1667796 | chr8_102861954_- | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_1379316 | chr8_102830135_- | SINE | Alu | Name=AluSz6 |
| ADediting_1379317 | chr8_102830258_- | SINE | Alu | Name=AluSz6 |
| ADediting_1379318 | chr8_102830264_- | SINE | Alu | Name=AluSz6 |
| ADediting_1379319 | chr8_102830278_- | SINE | Alu | Name=AluSz6 |
| ADediting_1379320 | chr8_102830294_- | SINE | Alu | Name=AluSz6 |
| ADediting_1379321 | chr8_102832709_- | SINE | Alu | Name=AluSx4 |
| ADediting_1379322 | chr8_102832749_- | SINE | Alu | Name=AluSx4 |
| ADediting_1379323 | chr8_102832769_- | SINE | Alu | Name=AluSx4 |
| ADediting_1379324 | chr8_102832778_- | SINE | Alu | Name=AluSx4 |
| ADediting_1379325 | chr8_102832779_- | SINE | Alu | Name=AluSx4 |
| ADediting_1379326 | chr8_102832785_- | SINE | Alu | Name=AluSx4 |
| ADediting_1379327 | chr8_102832805_- | SINE | Alu | Name=AluSx4 |
| ADediting_1379328 | chr8_102833837_- | SINE | Alu | Name=AluJr4 |
| ADediting_1379329 | chr8_102837039_- | SINE | Alu | Name=AluSz |
| ADediting_1379330 | chr8_102842051_- | SINE | Alu | Name=AluSq |
| ADediting_1379331 | chr8_102847330_- | SINE | Alu | Name=FLAM_C |
| ADediting_1379332 | chr8_102851463_- | SINE | Alu | Name=AluSg4 |
| ADediting_1379333 | chr8_102851473_- | SINE | Alu | Name=AluSg4 |
| ADediting_1379334 | chr8_102851514_- | SINE | Alu | Name=AluSg4 |
| ADediting_1379335 | chr8_102851623_- | SINE | Alu | Name=AluSg4 |
| ADediting_1379336 | chr8_102851630_- | SINE | Alu | Name=AluSg4 |
| ADediting_1379337 | chr8_102851637_- | SINE | Alu | Name=AluSg4 |
| ADediting_1379338 | chr8_102851643_- | SINE | Alu | Name=AluSg4 |
| ADediting_1379339 | chr8_102852489_- | SINE | Alu | Name=AluSq |
| ADediting_1379340 | chr8_102852557_- | SINE | Alu | Name=AluSq |
| ADediting_1379341 | chr8_102853242_- | SINE | Alu | Name=AluSq |
| ADediting_1379342 | chr8_102853248_- | SINE | Alu | Name=AluSq |
| ADediting_1379343 | chr8_102853254_- | SINE | Alu | Name=AluSq |
| ADediting_1379344 | chr8_102853260_- | SINE | Alu | Name=AluSq |
| ADediting_1379345 | chr8_102853311_- | SINE | Alu | Name=AluSq |
| ADediting_1379346 | chr8_102853318_- | SINE | Alu | Name=AluSq |
| ADediting_1379347 | chr8_102853337_- | SINE | Alu | Name=AluSq |
| ADediting_1379348 | chr8_102853340_- | SINE | Alu | Name=AluSq |
| ADediting_1379349 | chr8_102853370_- | SINE | Alu | Name=AluSq |
| ADediting_1379350 | chr8_102853380_- | SINE | Alu | Name=AluSq |
| ADediting_1379351 | chr8_102853433_- | SINE | Alu | Name=AluSq |
| ADediting_1379352 | chr8_102853439_- | SINE | Alu | Name=AluSq |
| ADediting_1379353 | chr8_102853450_- | SINE | Alu | Name=AluSq |
| ADediting_1379354 | chr8_102853464_- | SINE | Alu | Name=AluSq |
| ADediting_1379355 | chr8_102853471_- | SINE | Alu | Name=AluSq |
| ADediting_1379356 | chr8_102854009_- | SINE | Alu | Name=AluSx |
| ADediting_1379357 | chr8_102854010_- | SINE | Alu | Name=AluSx |
| ADediting_1379358 | chr8_102854018_- | SINE | Alu | Name=AluSx |
| ADediting_1379359 | chr8_102854067_- | SINE | Alu | Name=AluSx |
| ADediting_1379360 | chr8_102854072_- | SINE | Alu | Name=AluSx |
| ADediting_1379361 | chr8_102854073_- | SINE | Alu | Name=AluSx |
| ADediting_1379362 | chr8_102854170_- | SINE | Alu | Name=AluSx |
| ADediting_1379363 | chr8_102854181_- | SINE | Alu | Name=AluSx |
| ADediting_1379364 | chr8_102854212_- | SINE | Alu | Name=AluSx |
| ADediting_1379365 | chr8_102854218_- | SINE | Alu | Name=AluSx |
| ADediting_1379366 | chr8_102854342_- | SINE | Alu | Name=AluSx1 |
| ADediting_1379367 | chr8_102854344_- | SINE | Alu | Name=AluSx1 |
| ADediting_1379368 | chr8_102854355_- | SINE | Alu | Name=AluSx1 |
| ADediting_1379369 | chr8_102854356_- | SINE | Alu | Name=AluSx1 |
| ADediting_1379370 | chr8_102854408_- | SINE | Alu | Name=AluSx1 |
| ADediting_1379371 | chr8_102859714_- | SINE | Alu | Name=AluSz6 |
| ADediting_1379372 | chr8_102861313_- | SINE | Alu | Name=AluSq10 |
| ADediting_1379373 | chr8_102861324_- | SINE | Alu | Name=AluSq10 |
| ADediting_1379374 | chr8_102861325_- | SINE | Alu | Name=AluSq10 |
| ADediting_1379375 | chr8_102861333_- | SINE | Alu | Name=AluSq10 |
| ADediting_1379376 | chr8_102861365_- | SINE | Alu | Name=AluSq10 |
| ADediting_1379377 | chr8_102861366_- | SINE | Alu | Name=AluSq10 |
| ADediting_1379378 | chr8_102861392_- | SINE | Alu | Name=AluSq10 |
| ADediting_1379379 | chr8_102861403_- | SINE | Alu | Name=AluSq10 |
| ADediting_1379380 | chr8_102861405_- | SINE | Alu | Name=AluSq10 |
| ADediting_1379381 | chr8_102861407_- | SINE | Alu | Name=AluSq10 |
| ADediting_1379382 | chr8_102861410_- | SINE | Alu | Name=AluSq10 |
| ADediting_1379383 | chr8_102861494_- | SINE | Alu | Name=AluSq10 |
| ADediting_1379384 | chr8_102861495_- | SINE | Alu | Name=AluSq10 |
| ADediting_1379385 | chr8_102861783_- | SINE | Alu | Name=AluSx1 |
| ADediting_1379386 | chr8_102861868_- | SINE | Alu | Name=AluSx1 |
| ADediting_1379387 | chr8_102861869_- | SINE | Alu | Name=AluSx1 |
| ADediting_1379388 | chr8_102861873_- | SINE | Alu | Name=AluSx1 |
| ADediting_1379389 | chr8_102861914_- | SINE | Alu | Name=AluSx1 |
| ADediting_1379390 | chr8_102861936_- | SINE | Alu | Name=AluSx1 |
| ADediting_1379391 | chr8_102861953_- | SINE | Alu | Name=AluSx1 |
| ADediting_1589370 | chr8_102830212_- | SINE | Alu | Name=AluSz6 |
| ADediting_1589371 | chr8_102830223_- | SINE | Alu | Name=AluSz6 |
| ADediting_1589372 | chr8_102830361_- | SINE | Alu | Name=AluSz6 |
| ADediting_1589373 | chr8_102840491_- | SINE | Alu | Name=FRAM |
| ADediting_1667788 | chr8_102832869_- | SINE | Alu | Name=AluSx4 |
| ADediting_1667789 | chr8_102853323_- | SINE | Alu | Name=AluSq |
| ADediting_1667790 | chr8_102853984_- | SINE | Alu | Name=AluSx |
| ADediting_1667791 | chr8_102854419_- | SINE | Alu | Name=AluSx1 |
| ADediting_1667792 | chr8_102861336_- | SINE | Alu | Name=AluSq10 |
| ADediting_1667793 | chr8_102861401_- | SINE | Alu | Name=AluSq10 |
| ADediting_1667794 | chr8_102861786_- | SINE | Alu | Name=AluSx1 |
| ADediting_1667795 | chr8_102861870_- | SINE | Alu | Name=AluSx1 |
| ADediting_1667796 | chr8_102861954_- | SINE | Alu | Name=AluSx1 |
Top |
RNA A-to-I editing events in the alternative splicing sites for AZIN1 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| A3SS | ADediting_1589371 | chr8_102830223_- | 102830216:102830238 | 3ss | 5i | AATTTTTGTATTTTTAGTAGAGA | 2.24 | AATTTTTGTATTTTTGGTAGAGA | 3.66 |
| A3SS | ADediting_1589371 | chr8_102830223_- | 102830219:102830241 | 3ss | 2i | GCTAATTTTTGTATTTTTAGTAG | 3.60 | GCTAATTTTTGTATTTTTGGTAG | -4.36 |
| ES | ADediting_1589371 | chr8_102830223_- | 102830216:102830238 | 3ss | 5i | AATTTTTGTATTTTTAGTAGAGA | 2.24 | AATTTTTGTATTTTTGGTAGAGA | 3.66 |
| ES | ADediting_1589371 | chr8_102830223_- | 102830219:102830241 | 3ss | 2i | GCTAATTTTTGTATTTTTAGTAG | 3.60 | GCTAATTTTTGTATTTTTGGTAG | -4.36 |
| ES | ADediting_1589371 | chr8_102830223_- | 102830216:102830238 | 3ss | 5i | AATTTTTGTATTTTTAGTAGAGA | 2.24 | AATTTTTGTATTTTTGGTAGAGA | 3.66 |
| ES | ADediting_1589371 | chr8_102830223_- | 102830219:102830241 | 3ss | 2i | GCTAATTTTTGTATTTTTAGTAG | 3.60 | GCTAATTTTTGTATTTTTGGTAG | -4.36 |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
Top |
Differntial gene expression between RNA A-to-I edited versus non-edited samples for AZIN1 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for AZIN1 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for AZIN1 |
| RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. |
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| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1379315 | chr8_102829408_- | ENSG00000155096.14 | ENST00000518697.1 | AZIN1-205 | hsa-miR-3614-3p | chr8 | 102829405 | 102829411 | 7mer-m8 | 102829404 | 102829427 | 153 | -16.97 |
| ADediting_1379315 | chr8_102829408_- | ENSG00000155096.14 | ENST00000518697.1 | AZIN1-205 | hsa-miR-4297 | chr8 | 102829406 | 102829412 | 7mer-m8 | 102829405 | 102829420 | 140 | -11.94 |
| ADediting_1379315 | chr8_102829408_- | ENSG00000155096.14 | ENST00000518697.1 | AZIN1-205 | hsa-miR-5581-5p | chr8 | 102829406 | 102829412 | 7mer-m8 | 102829405 | 102829426 | 148 | -18.95 |
| ADediting_1379316 | chr8_102830135_- | ENSG00000155096.14 | ENST00000518697.1 | AZIN1-205 | hsa-miR-383-3p | chr8 | 102830135 | 102830141 | 7mer-m8 | 102830134 | 102830152 | 142 | -13.58 |
| ADediting_1379316 | chr8_102830135_- | ENSG00000155096.14 | ENST00000518697.1 | AZIN1-205 | hsa-miR-7977 | chr8 | 102830132 | 102830138 | 7mer-m8 | 102830131 | 102830148 | 140 | -13.07 |
| ADediting_1589370 | chr8_102830212_- | ENSG00000155096.14 | ENST00000518697.1 | AZIN1-205 | hsa-miR-548as-3p | chr8 | 102830207 | 102830213 | 7mer-m8 | 102830206 | 102830226 | 153 | -12.51 |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_107020 | chr1_37500952_- | ENSG00000155096.14 | ENST00000337198.10 | AZIN1-201 | hsa-miR-5581-3p | chr8 | 102827515 | 102827522 | 8mer-1a | 102827515 | 102827536 | 140 | -15.65 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000155096.14 | ENST00000337198.10 | AZIN1-201 | hsa-miR-5688 | chr8 | 102828340 | 102828346 | 7mer-m8 | 102828339 | 102828364 | 142 | -10.6 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000155096.14 | ENST00000347770.8 | AZIN1-202 | hsa-miR-5688 | chr8 | 102828340 | 102828346 | 7mer-m8 | 102828339 | 102828364 | 142 | -10.6 |
| ADediting_1337758 | chr7_5495892_- | ENSG00000155096.14 | ENST00000337198.10 | AZIN1-201 | hsa-miR-589-5p | chr8 | 102828260 | 102828266 | 7mer-m8 | 102828259 | 102828280 | 140 | -14.36 |
| ADediting_1337758 | chr7_5495892_- | ENSG00000155096.14 | ENST00000347770.8 | AZIN1-202 | hsa-miR-589-5p | chr8 | 102828260 | 102828266 | 7mer-m8 | 102828259 | 102828280 | 140 | -14.36 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000155096.14 | ENST00000337198.10 | AZIN1-201 | hsa-miR-4775 | chr8 | 102828414 | 102828420 | 7mer-m8 | 102828413 | 102828431 | 154 | -16.34 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000155096.14 | ENST00000347770.8 | AZIN1-202 | hsa-miR-4775 | chr8 | 102828414 | 102828420 | 7mer-m8 | 102828413 | 102828431 | 154 | -16.34 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1337757 | chr7_5495852_- | ENSG00000155096.14 | ENST00000337198.10 | AZIN1-201 | hsa-miR-589-3p | chr8 | 102827378 | 102827384 | 7mer-m8 | 102827377 | 102827400 | 155 | -14.84 |
| ADediting_1535953 | chr14_101045971_+ | ENSG00000155096.14 | ENST00000337198.10 | AZIN1-201 | hsa-miR-381-3p | chr8 | 102828032 | 102828038 | 7mer-m8 | 102828031 | 102828052 | 150 | -16.52 |
| ADediting_1535953 | chr14_101045971_+ | ENSG00000155096.14 | ENST00000347770.8 | AZIN1-202 | hsa-miR-381-3p | chr8 | 102828032 | 102828038 | 7mer-m8 | 102828031 | 102828052 | 150 | -16.52 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000155096.14 | ENST00000337198.10 | AZIN1-201 | hsa-miR-381-3p | chr8 | 102828032 | 102828038 | 7mer-m8 | 102828031 | 102828052 | 150 | -16.52 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000155096.14 | ENST00000347770.8 | AZIN1-202 | hsa-miR-381-3p | chr8 | 102828032 | 102828038 | 7mer-m8 | 102828031 | 102828052 | 150 | -16.52 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000155096.14 | ENST00000337198.10 | AZIN1-201 | hsa-miR-641 | chr8 | 102828183 | 102828189 | 7mer-m8 | 102828182 | 102828204 | 143 | -12.45 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000155096.14 | ENST00000347770.8 | AZIN1-202 | hsa-miR-641 | chr8 | 102828183 | 102828189 | 7mer-m8 | 102828182 | 102828204 | 143 | -12.45 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000155096.14 | ENST00000337198.10 | AZIN1-201 | hsa-miR-641 | chr8 | 102828183 | 102828189 | 7mer-m8 | 102828182 | 102828204 | 143 | -12.45 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000155096.14 | ENST00000347770.8 | AZIN1-202 | hsa-miR-641 | chr8 | 102828183 | 102828189 | 7mer-m8 | 102828182 | 102828204 | 143 | -12.45 |
| Differentially expressed gene-miRNA network |
Top |
The effects of the RNA editing to the stability of the RNA structures for AZIN1 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000518697.1 | lncRNA |  |  |
| ENST00000337198.10 | protein_coding |  |  |
| ENST00000347770.8 | protein_coding |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_1379315 | ENST00000337198.10 | chr8_102829408_- | 1689 | -1152.60 | -1152.90 | -1152.60 |
| ADediting_1379315 | ENST00000347770.8 | chr8_102829408_- | 1865 | -806.40 | -806.70 | -806.40 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_1379315 | ENST00000518697.1 | chr8_102829408_- | 297 | -177.40 | -177.70 | -180.00 |
| ADediting_1379316 | ENST00000518697.1 | chr8_102830135_- | 93 | -178.10 | -177.70 | -180.00 |
| ADediting_1589370 | ENST00000518697.1 | chr8_102830212_- | 16 | -179.80 | -177.70 | -180.00 |
| ADediting_1589371 | ENST00000518697.1 | chr8_102830223_- | 5 | -179.90 | -177.70 | -180.00 |
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Relation with ADAR for AZIN1 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| STG | ADediting_1379315 | chr8_102829408_- | 0.914036396586787 | 0.0119569092214004 | 0.0266173765314414 | -0.241923129022423 | 5.58194371061629e-05 | 0.4250189408066 |
| DLPFC | ADediting_1379341 | chr8_102853242_- | 0.47470302180228 | 0.0407483809063859 | 0.0834166369261385 | -0.0984840737535388 | 1.67586673250712e-13 | 0.402506408892007 |
| DLPFC | ADediting_1379343 | chr8_102853254_- | 0.231620406834003 | 0.068135591848942 | 0.149797314185683 | -0.081994017924102 | 9.62397263594656e-17 | 0.448450769185231 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 4.0218114527225e-59 | 0.758052998234366 | 1.9571915532259e-35 | 0.62817201478522 | 0.605104790042307 | 0.0294805163961224 |
| AC | 2.34536620623897e-63 | 0.824820929509052 | 4.14497093428921e-33 | 0.663622401146537 | 5.1584389590421e-20 | 0.536233743912017 |
| PCC | 1.91059127168041e-46 | 0.813901197743452 | 6.86776807222253e-44 | 0.800505160278136 | 0.0487908607007883 | 0.142780131529376 |
| CER | 5.47426894173067e-37 | 0.815591264253539 | 8.64374128788238e-18 | 0.627400398699286 | 0.156206040925287 | 0.116354675155282 |
| TCX | 1.63806872721085e-50 | 0.883153500144627 | 5.67096260119905e-17 | 0.614965248316259 | 0.193545824648606 | 0.106747088805427 |
| FP | 7.61363165159968e-15 | 0.53971792919316 | 3.13187204934267e-22 | 0.643970011097468 | 0.652542076782619 | -0.0339760524784023 |
| IFG | 0.000530874389156384 | 0.642707542486101 | 0.0294704096633394 | 0.43571172974628 | 0.549507273615964 | -0.125656868181004 |
| PG | 1.8815328258704e-53 | 0.851396643205168 | 1.60191033154722e-26 | 0.679324293930408 | 0.752430602996922 | -0.0232827128418414 |
| STG | 5.12833794104249e-14 | 0.707831678191692 | 1.26369617403693e-14 | 0.719445601164696 | 0.352524874651863 | -0.102709292800208 |
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Relation with AD stages for AZIN1 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| STG | 0.00493911517431552 | -0.303964673498064 |
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RelatedDrugs for AZIN1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for AZIN1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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