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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for RWDD1 |
 Gene summary |
| Gene information | Gene symbol | RWDD1 | Gene ID | 51389 |
| Gene name | RWD domain containing 1 | |
| Synonyms | CGI-24|PTD013 | |
| Cytomap | 6q22.1 | |
| Type of gene | protein-coding | |
| Description | RWD domain-containing protein 1DRG family-regulatory protein 2 | |
| Modification date | 20200313 | |
| UniProtAcc | Q9H446, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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RNA A-to-I events for RWDD1 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_1226850(116593690, +), ADediting_1226851(116593691, +), ADediting_1226852(116593696, +), ADediting_1226853(116593758, +), ADediting_1226854(116593760, +), ADediting_1226855(116593767, +), ADediting_1226856(116593768, +), ADediting_1226857(116593824, +), |
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RNA editing positional annotations for RWDD1 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_1226850 | chr6_116593690_+ | UTR3 |
| ADediting_1226851 | chr6_116593691_+ | UTR3 |
| ADediting_1226852 | chr6_116593696_+ | UTR3 |
| ADediting_1226853 | chr6_116593758_+ | UTR3 |
| ADediting_1226854 | chr6_116593760_+ | UTR3 |
| ADediting_1226855 | chr6_116593767_+ | UTR3 |
| ADediting_1226856 | chr6_116593768_+ | UTR3 |
| ADediting_1226857 | chr6_116593824_+ | UTR3 |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_1226850 | chr6_116593690_+ | SINE | Alu | Name=AluY |
| ADediting_1226851 | chr6_116593691_+ | SINE | Alu | Name=AluY |
| ADediting_1226852 | chr6_116593696_+ | SINE | Alu | Name=AluY |
| ADediting_1226853 | chr6_116593758_+ | SINE | Alu | Name=AluY |
| ADediting_1226854 | chr6_116593760_+ | SINE | Alu | Name=AluY |
| ADediting_1226855 | chr6_116593767_+ | SINE | Alu | Name=AluY |
| ADediting_1226856 | chr6_116593768_+ | SINE | Alu | Name=AluY |
| ADediting_1226857 | chr6_116593824_+ | SINE | Alu | Name=AluY |
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RNA A-to-I editing events in the alternative splicing sites for RWDD1 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for RWDD1 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for RWDD1 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for RWDD1 |
| RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. |
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| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1226850 | chr6_116593690_+ | ENSG00000111832.13 | ENST00000466444.7 | RWDD1-202 | hsa-miR-513a-5p | chr6 | 116593684 | 116593690 | 7mer-m8 | 116593674 | 116593691 | 144 | -16.68 |
| ADediting_1226850 | chr6_116593690_+ | ENSG00000111832.13 | ENST00000466444.7 | RWDD1-202 | hsa-miR-638 | chr6 | 116593689 | 116593695 | 7mer-1a | 116593671 | 116593695 | 159 | -35.56 |
| ADediting_1226851 | chr6_116593691_+ | ENSG00000111832.13 | ENST00000466444.7 | RWDD1-202 | hsa-miR-8052 | chr6 | 116593689 | 116593695 | 7mer-1a | 116593677 | 116593695 | 140 | -24.15 |
| ADediting_1226852 | chr6_116593696_+ | ENSG00000111832.13 | ENST00000466444.7 | RWDD1-202 | hsa-miR-371a-3p | chr6 | 116593694 | 116593700 | 7mer-m8 | 116593679 | 116593701 | 145 | -17.36 |
| ADediting_1226855 | chr6_116593767_+ | ENSG00000111832.13 | ENST00000466444.7 | RWDD1-202 | hsa-miR-1229-3p | chr6 | 116593761 | 116593767 | 7mer-m8 | 116593746 | 116593768 | 140 | -13.5 |
| ADediting_1226856 | chr6_116593768_+ | ENSG00000111832.13 | ENST00000466444.7 | RWDD1-202 | hsa-miR-412-3p | chr6 | 116593761 | 116593767 | 7mer-m8 | 116593746 | 116593768 | 151 | -19.78 |
| ADediting_1226856 | chr6_116593768_+ | ENSG00000111832.13 | ENST00000466444.7 | RWDD1-202 | hsa-miR-4508 | chr6 | 116593766 | 116593772 | 7mer-m8 | 116593758 | 116593773 | 141 | -24.29 |
| ADediting_1226856 | chr6_116593768_+ | ENSG00000111832.13 | ENST00000466444.7 | RWDD1-202 | hsa-miR-6754-3p | chr6 | 116593761 | 116593767 | 7mer-m8 | 116593748 | 116593768 | 146 | -16.46 |
| ADediting_1226857 | chr6_116593824_+ | ENSG00000111832.13 | ENST00000466444.7 | RWDD1-202 | hsa-miR-140-3p | chr6 | 116593819 | 116593825 | 7mer-m8 | 116593803 | 116593826 | 152 | -25.52 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1226850 | chr6_116593690_+ | ENSG00000111832.13 | ENST00000466444.7 | RWDD1-202 | hsa-miR-10399-5p | chr6 | 116593685 | 116593691 | 7mer-m8 | 116593671 | 116593692 | 144 | -11.2 |
| ADediting_1226850 | chr6_116593690_+ | ENSG00000111832.13 | ENST00000466444.7 | RWDD1-202 | hsa-miR-6504-3p | chr6 | 116593685 | 116593691 | 7mer-m8 | 116593671 | 116593692 | 148 | -14.35 |
| ADediting_1226850 | chr6_116593690_+ | ENSG00000111832.13 | ENST00000466444.7 | RWDD1-202 | hsa-miR-7151-3p | chr6 | 116593683 | 116593690 | 8mer-1a | 116593670 | 116593690 | 144 | -16.51 |
| ADediting_1226851 | chr6_116593691_+ | ENSG00000111832.13 | ENST00000466444.7 | RWDD1-202 | hsa-miR-10399-5p | chr6 | 116593685 | 116593691 | 7mer-m8 | 116593671 | 116593692 | 144 | -11.2 |
| ADediting_1226851 | chr6_116593691_+ | ENSG00000111832.13 | ENST00000466444.7 | RWDD1-202 | hsa-miR-5089-5p | chr6 | 116593689 | 116593695 | 7mer-m8 | 116593674 | 116593696 | 148 | -14.13 |
| ADediting_1226851 | chr6_116593691_+ | ENSG00000111832.13 | ENST00000466444.7 | RWDD1-202 | hsa-miR-6504-3p | chr6 | 116593685 | 116593691 | 7mer-m8 | 116593671 | 116593692 | 148 | -14.35 |
| ADediting_1226852 | chr6_116593696_+ | ENSG00000111832.13 | ENST00000466444.7 | RWDD1-202 | hsa-miR-5089-5p | chr6 | 116593689 | 116593695 | 7mer-m8 | 116593674 | 116593696 | 148 | -14.13 |
| ADediting_1226852 | chr6_116593696_+ | ENSG00000111832.13 | ENST00000466444.7 | RWDD1-202 | hsa-miR-512-3p | chr6 | 116593694 | 116593700 | 7mer-m8 | 116593680 | 116593701 | 149 | -15.51 |
| ADediting_1226852 | chr6_116593696_+ | ENSG00000111832.13 | ENST00000466444.7 | RWDD1-202 | hsa-miR-6506-5p | chr6 | 116593690 | 116593696 | 7mer-m8 | 116593675 | 116593697 | 144 | -13.78 |
| ADediting_1226853 | chr6_116593758_+ | ENSG00000111832.13 | ENST00000466444.7 | RWDD1-202 | hsa-miR-3152-3p | chr6 | 116593754 | 116593760 | 7mer-m8 | 116593741 | 116593761 | 145 | -18.08 |
| ADediting_1226854 | chr6_116593760_+ | ENSG00000111832.13 | ENST00000466444.7 | RWDD1-202 | hsa-miR-3152-3p | chr6 | 116593754 | 116593760 | 7mer-m8 | 116593741 | 116593761 | 145 | -18.08 |
| ADediting_1226855 | chr6_116593767_+ | ENSG00000111832.13 | ENST00000466444.7 | RWDD1-202 | hsa-miR-193b-5p | chr6 | 116593765 | 116593771 | 7mer-m8 | 116593751 | 116593772 | 142 | -17.8 |
| ADediting_1226856 | chr6_116593768_+ | ENSG00000111832.13 | ENST00000466444.7 | RWDD1-202 | hsa-miR-193b-5p | chr6 | 116593765 | 116593771 | 7mer-m8 | 116593751 | 116593772 | 142 | -17.8 |
| ADediting_1226857 | chr6_116593824_+ | ENSG00000111832.13 | ENST00000466444.7 | RWDD1-202 | hsa-miR-8052 | chr6 | 116593823 | 116593829 | 7mer-1a | 116593809 | 116593829 | 141 | -20.59 |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000111832.13 | ENST00000466444.7 | RWDD1-202 | hsa-miR-5688 | chr6 | 116595045 | 116595051 | 7mer-m8 | 116595031 | 116595052 | 143 | -10.6 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000111832.13 | ENST00000466444.7 | RWDD1-202 | hsa-miR-5688 | chr6 | 116596142 | 116596148 | 7mer-m8 | 116596128 | 116596149 | 145 | -12.03 |
| ADediting_1391023 | chr8_140732605_- | ENSG00000111832.13 | ENST00000466444.7 | RWDD1-202 | hsa-miR-151a-3p | chr6 | 116597254 | 116597260 | 7mer-m8 | 116597239 | 116597261 | 152 | -17.88 |
| ADediting_1471004 | chr9_63819627_+ | ENSG00000111832.13 | ENST00000466444.7 | RWDD1-202 | hsa-miR-4477b | chr6 | 116595670 | 116595676 | 7mer-m8 | 116595655 | 116595677 | 151 | -18.37 |
| ADediting_496066 | chr15_66496985_- | ENSG00000111832.13 | ENST00000466444.7 | RWDD1-202 | hsa-miR-4512 | chr6 | 116594406 | 116594412 | 7mer-m8 | 116594391 | 116594413 | 149 | -20.36 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000111832.13 | ENST00000466444.7 | RWDD1-202 | hsa-miR-4775 | chr6 | 116593316 | 116593322 | 7mer-m8 | 116593302 | 116593323 | 140 | -9.12 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000111832.13 | ENST00000487832.6 | RWDD1-204 | hsa-miR-4775 | chr6 | 116593316 | 116593322 | 7mer-m8 | 116593302 | 116593323 | 140 | -9.12 |
| ADediting_98288 | chr1_32086990_+ | ENSG00000111832.13 | ENST00000466444.7 | RWDD1-202 | hsa-miR-5585-3p | chr6 | 116597249 | 116597255 | 7mer-m8 | 116597235 | 116597256 | 140 | -14.9 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000111832.13 | ENST00000466444.7 | RWDD1-202 | hsa-miR-5688 | chr6 | 116596323 | 116596329 | 7mer-m8 | 116596309 | 116596330 | 148 | -9.4 |
| ADediting_527135 | chr16_24203190_+ | ENSG00000111832.13 | ENST00000466444.7 | RWDD1-202 | hsa-miR-1273h-3p | chr6 | 116594618 | 116594625 | 8mer-1a | 116594599 | 116594625 | 146 | -22.83 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000111832.13 | ENST00000466444.7 | RWDD1-202 | hsa-miR-4775 | chr6 | 116594923 | 116594929 | 7mer-m8 | 116594910 | 116594930 | 150 | -2.27 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000111832.13 | ENST00000466444.7 | RWDD1-202 | hsa-miR-4775 | chr6 | 116595712 | 116595719 | 8mer-1a | 116595698 | 116595719 | 151 | -7.14 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for RWDD1 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000466444.7 | protein_coding |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_1226850 | ENST00000466444.7 | chr6_116593690_+ | 1400 | -1401.60 | -1400.00 | -1407.10 |
| ADediting_1226851 | ENST00000466444.7 | chr6_116593691_+ | 1401 | -1400.00 | -1400.00 | -1407.10 |
| ADediting_1226852 | ENST00000466444.7 | chr6_116593696_+ | 1406 | -1403.40 | -1400.00 | -1407.10 |
| ADediting_1226853 | ENST00000466444.7 | chr6_116593758_+ | 1468 | -1399.70 | -1400.00 | -1407.10 |
| ADediting_1226854 | ENST00000466444.7 | chr6_116593760_+ | 1470 | -1400.50 | -1400.00 | -1407.10 |
| ADediting_1226855 | ENST00000466444.7 | chr6_116593767_+ | 1477 | -1401.60 | -1400.00 | -1407.10 |
| ADediting_1226856 | ENST00000466444.7 | chr6_116593768_+ | 1478 | -1400.00 | -1400.00 | -1407.10 |
| ADediting_1226857 | ENST00000466444.7 | chr6_116593824_+ | 1534 | -1403.10 | -1400.00 | -1407.10 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for RWDD1 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 8.01466265420777e-12 | 0.375593822668382 | 1.03757916032097e-19 | 0.485178410291576 | 0.139251790604079 | 0.0841688131967925 |
| AC | 1.00417758999375e-65 | 0.833102299460913 | 1.42117655296977e-44 | 0.739806282720275 | 1.5255929688569e-16 | 0.490555687905461 |
| PCC | 3.3393070144509e-21 | 0.614330917865697 | 4.8611990563654e-23 | 0.635957549471083 | 0.0408167218401714 | 0.148153785164822 |
| CER | 1.88245547692077e-30 | 0.768114084891481 | 2.38453442924166e-20 | 0.663054515722524 | 0.0357765513655799 | 0.171581998699132 |
| TCX | 5.48842235936775e-26 | 0.727483125721085 | 0.000331317701905867 | 0.289211813295548 | 2.16013054544437e-08 | 0.437533199934273 |
| FP | 6.63054758658183e-15 | 0.540734134492875 | 5.54262324811667e-16 | 0.55841562959953 | 0.509997852443369 | 0.0497018540408202 |
| IFG | 0.0185103049375334 | 0.467296875822282 | 0.126957022860275 | 0.313538031588526 | 0.849272969270915 | -0.040044179258282 |
| PG | 3.3470498316278e-49 | 0.833107646915755 | 8.46033934045537e-23 | 0.639742490017955 | 0.941651713786743 | -0.00540323270620469 |
| STG | 4.46045890055543e-18 | 0.77583487259431 | 4.72149331039195e-16 | 0.74458720449627 | 0.682679741460438 | 0.0452600328779452 |
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Relation with AD stages for RWDD1 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| CER | ADediting_1226850 | chr6_116593690_+ | 7.26901752332734e-05 | 0.372270348334432 |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 0.000782540687539788 | 0.318457959550942 |
| TCX | 0.000370002993308936 | 0.339529407562419 |
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RelatedDrugs for RWDD1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RWDD1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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