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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited versus non-edited samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with AD stages

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene


Gene summary for ZBTB7A

check button Gene summary
Gene informationGene symbol

ZBTB7A

Gene ID

51341

Gene namezinc finger and BTB domain containing 7A
SynonymsFBI-1|FBI1|LRF|TIP21|ZBTB7|ZNF857A|pokemon
Cytomap

19p13.3

Type of geneprotein-coding
Descriptionzinc finger and BTB domain-containing protein 7AHIV-1 1st-binding protein 1HIV-1 inducer of short transcripts binding proteinPOK erythroid myeloid ontogenic factorPOZ and Krueppel erythroid myeloid ontogenic factorTTF-I-interacting peptide 21factor
Modification date20200322
UniProtAcc

O95365,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
ZBTB7A

GO:0000381

regulation of alternative mRNA splicing, via spliceosome

24514149

ZBTB7A

GO:0006355

regulation of transcription, DNA-templated

14701838|17595526

ZBTB7A

GO:0045892

negative regulation of transcription, DNA-templated

12004059

ZBTB7A

GO:0051092

positive regulation of NF-kappaB transcription factor activity

15917220

ZBTB7A

GO:2000677

regulation of transcription regulatory region DNA binding

12004059


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RNA A-to-I events for ZBTB7A

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_751618(4048586, -), ADediting_751621(4048613, -), ADediting_751622(4048614, -), ADediting_751626(4048639, -), ADediting_751629(4048659, -), ADediting_751631(4048731, -), ADediting_751632(4048753, -), ADediting_751642(4049282, -), ADediting_751643(4049283, -), ADediting_751644(4049295, -), ADediting_751645(4049326, -), ADediting_751647(4049407, -), ADediting_751683(4050006, -), ADediting_751684(4050020, -), ADediting_751685(4050021, -), ADediting_751686(4050029, -), ADediting_751687(4050032, -), ADediting_751688(4050033, -), ADediting_751689(4050035, -), ADediting_751690(4050039, -), ADediting_751691(4050052, -), ADediting_751693(4050061, -), ADediting_751700(4050085, -), ADediting_751701(4050118, -), ADediting_751702(4050119, -), ADediting_751703(4050126, -), ADediting_751704(4050138, -), ADediting_751705(4050162, -), ADediting_751706(4050220, -), ADediting_751707(4050224, -), ADediting_751708(4050233, -), ADediting_751709(4050262, -), ADediting_751710(4050269, -), ADediting_751750(4050854, -), ADediting_751752(4050855, -), ADediting_751760(4050882, -), ADediting_751761(4050907, -), ADediting_751765(4050933, -), ADediting_751767(4050936, -), ADediting_751774(4050950, -), ADediting_751778(4050951, -), ADediting_751781(4050986, -), ADediting_751782(4050998, -), ADediting_751783(4051022, -), ADediting_751860(4051668, -), ADediting_752194(4055510, -), ADediting_752195(4055511, -), ADediting_752196(4055520, -), ADediting_752197(4055566, -), ADediting_752198(4055578, -), ADediting_752199(4055579, -), ADediting_752200(4055633, -), ADediting_752202(4055701, -), ADediting_752261(4055895, -), ADediting_752262(4055896, -), ADediting_752348(4056475, -), ADediting_752350(4056481, -), ADediting_752352(4056509, -), ADediting_752353(4056510, -), ADediting_752444(4057533, -), ADediting_752445(4057545, -), ADediting_752449(4058362, -), ADediting_752457(4060547, -), ADediting_1556085(4048777, -), ADediting_1556087(4050093, -), ADediting_1556088(4050098, -), ADediting_1556089(4050165, -), ADediting_1556090(4050522, -), ADediting_1556104(4051656, -), ADediting_1556119(4057619, -), ADediting_1631461(4050104, -), ADediting_1631462(4050141, -),

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RNA editing positional annotations for ZBTB7A using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_751618chr19_4048586_-intronic
ADediting_751621chr19_4048613_-intronic
ADediting_751622chr19_4048614_-intronic
ADediting_751626chr19_4048639_-intronic
ADediting_751629chr19_4048659_-intronic
ADediting_751631chr19_4048731_-intronic
ADediting_751632chr19_4048753_-intronic
ADediting_751642chr19_4049282_-intronic
ADediting_751643chr19_4049283_-intronic
ADediting_751644chr19_4049295_-intronic
ADediting_751645chr19_4049326_-intronic
ADediting_751647chr19_4049407_-intronic
ADediting_751683chr19_4050006_-intronic
ADediting_751684chr19_4050020_-intronic
ADediting_751685chr19_4050021_-intronic
ADediting_751686chr19_4050029_-intronic
ADediting_751687chr19_4050032_-intronic
ADediting_751688chr19_4050033_-intronic
ADediting_751689chr19_4050035_-intronic
ADediting_751690chr19_4050039_-intronic
ADediting_751691chr19_4050052_-intronic
ADediting_751693chr19_4050061_-intronic
ADediting_751700chr19_4050085_-intronic
ADediting_751701chr19_4050118_-intronic
ADediting_751702chr19_4050119_-intronic
ADediting_751703chr19_4050126_-intronic
ADediting_751704chr19_4050138_-intronic
ADediting_751705chr19_4050162_-intronic
ADediting_751706chr19_4050220_-intronic
ADediting_751707chr19_4050224_-intronic
ADediting_751708chr19_4050233_-intronic
ADediting_751709chr19_4050262_-intronic
ADediting_751710chr19_4050269_-intronic
ADediting_751750chr19_4050854_-intronic
ADediting_751752chr19_4050855_-intronic
ADediting_751760chr19_4050882_-intronic
ADediting_751761chr19_4050907_-intronic
ADediting_751765chr19_4050933_-intronic
ADediting_751767chr19_4050936_-intronic
ADediting_751774chr19_4050950_-intronic
ADediting_751778chr19_4050951_-intronic
ADediting_751781chr19_4050986_-intronic
ADediting_751782chr19_4050998_-intronic
ADediting_751783chr19_4051022_-intronic
ADediting_751860chr19_4051668_-intronic
ADediting_752194chr19_4055510_-intronic
ADediting_752195chr19_4055511_-intronic
ADediting_752196chr19_4055520_-intronic
ADediting_752197chr19_4055566_-intronic
ADediting_752198chr19_4055578_-intronic
ADediting_752199chr19_4055579_-intronic
ADediting_752200chr19_4055633_-intronic
ADediting_752202chr19_4055701_-intronic
ADediting_752261chr19_4055895_-intronic
ADediting_752262chr19_4055896_-intronic
ADediting_752348chr19_4056475_-intronic
ADediting_752350chr19_4056481_-intronic
ADediting_752352chr19_4056509_-intronic
ADediting_752353chr19_4056510_-intronic
ADediting_752444chr19_4057533_-intronic
ADediting_752445chr19_4057545_-intronic
ADediting_752449chr19_4058362_-intronic
ADediting_752457chr19_4060547_-intronic
ADediting_1556085chr19_4048777_-intronic
ADediting_1556087chr19_4050093_-intronic
ADediting_1556088chr19_4050098_-intronic
ADediting_1556089chr19_4050165_-intronic
ADediting_1556090chr19_4050522_-intronic
ADediting_1556104chr19_4051656_-intronic
ADediting_1556119chr19_4057619_-intronic
ADediting_1631461chr19_4050104_-intronic
ADediting_1631462chr19_4050141_-intronic

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_751618chr19_4048586_-SINEAluName=AluSx1
ADediting_751621chr19_4048613_-SINEAluName=AluSx1
ADediting_751622chr19_4048614_-SINEAluName=AluSx1
ADediting_751626chr19_4048639_-SINEAluName=AluSx1
ADediting_751629chr19_4048659_-SINEAluName=AluSx1
ADediting_751631chr19_4048731_-SINEAluName=AluSx1
ADediting_751632chr19_4048753_-SINEAluName=AluSx1
ADediting_751642chr19_4049282_-SINEAluName=AluJb
ADediting_751643chr19_4049283_-SINEAluName=AluJb
ADediting_751644chr19_4049295_-SINEAluName=AluJb
ADediting_751645chr19_4049326_-SINEAluName=AluJb
ADediting_751683chr19_4050006_-SINEAluName=AluSx1
ADediting_751684chr19_4050020_-SINEAluName=AluSx1
ADediting_751685chr19_4050021_-SINEAluName=AluSx1
ADediting_751686chr19_4050029_-SINEAluName=AluSx1
ADediting_751687chr19_4050032_-SINEAluName=AluSx1
ADediting_751688chr19_4050033_-SINEAluName=AluSx1
ADediting_751689chr19_4050035_-SINEAluName=AluSx1
ADediting_751690chr19_4050039_-SINEAluName=AluSx1
ADediting_751691chr19_4050052_-SINEAluName=AluSx1
ADediting_751693chr19_4050061_-SINEAluName=AluSx1
ADediting_751700chr19_4050085_-SINEAluName=AluSx1
ADediting_751701chr19_4050118_-SINEAluName=AluSx1
ADediting_751702chr19_4050119_-SINEAluName=AluSx1
ADediting_751703chr19_4050126_-SINEAluName=AluSx1
ADediting_751704chr19_4050138_-SINEAluName=AluSx1
ADediting_751705chr19_4050162_-SINEAluName=AluSx1
ADediting_751706chr19_4050220_-SINEAluName=AluSx1
ADediting_751707chr19_4050224_-SINEAluName=AluSz
ADediting_751708chr19_4050233_-SINEAluName=AluSz
ADediting_751709chr19_4050262_-SINEAluName=AluSz
ADediting_751710chr19_4050269_-SINEAluName=AluSz
ADediting_751750chr19_4050854_-SINEAluName=AluSx1
ADediting_751752chr19_4050855_-SINEAluName=AluSx1
ADediting_751760chr19_4050882_-SINEAluName=AluSx1
ADediting_751761chr19_4050907_-SINEAluName=AluSx1
ADediting_751765chr19_4050933_-SINEAluName=AluSx1
ADediting_751767chr19_4050936_-SINEAluName=AluSx1
ADediting_751774chr19_4050950_-SINEAluName=AluSx1
ADediting_751778chr19_4050951_-SINEAluName=AluSx1
ADediting_751781chr19_4050986_-SINEAluName=AluSx1
ADediting_751782chr19_4050998_-SINEAluName=AluSx1
ADediting_751783chr19_4051022_-SINEAluName=AluSx1
ADediting_752194chr19_4055510_-SINEAluName=AluSz
ADediting_752195chr19_4055511_-SINEAluName=AluSz
ADediting_752196chr19_4055520_-SINEAluName=AluSz
ADediting_752197chr19_4055566_-SINEAluName=AluY
ADediting_752198chr19_4055578_-SINEAluName=AluY
ADediting_752199chr19_4055579_-SINEAluName=AluY
ADediting_752200chr19_4055633_-SINEAluName=AluY
ADediting_752202chr19_4055701_-SINEAluName=AluY
ADediting_752261chr19_4055895_-SINEAluName=AluSz
ADediting_752262chr19_4055896_-SINEAluName=AluSz
ADediting_752348chr19_4056475_-SINEAluName=AluSz
ADediting_752350chr19_4056481_-SINEAluName=AluSz
ADediting_752352chr19_4056509_-SINEAluName=AluSz
ADediting_752353chr19_4056510_-SINEAluName=AluSz
ADediting_752444chr19_4057533_-SINEAluName=AluSc
ADediting_752445chr19_4057545_-SINEAluName=AluSc
ADediting_752449chr19_4058362_-SINEMIRName=MIR3
ADediting_1556085chr19_4048777_-SINEAluName=AluSx1
ADediting_1556087chr19_4050093_-SINEAluName=AluSx1
ADediting_1556088chr19_4050098_-SINEAluName=AluSx1
ADediting_1556089chr19_4050165_-SINEAluName=AluSx1
ADediting_1556119chr19_4057619_-SINEAluName=AluSc
ADediting_1631461chr19_4050104_-SINEAluName=AluSx1
ADediting_1631462chr19_4050141_-SINEAluName=AluSx1

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RNA A-to-I editing events in the alternative splicing sites for ZBTB7A

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for ZBTB7A

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
boxplot
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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ADeditome IDChrPositoingSkipped exonENSGENSTs

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Protein coding region RNA A-to-I editings for ZBTB7A

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for ZBTB7A


check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1337757chr7_5495852_-ENSG00000178951.9ENST00000322357.9ZBTB7A-201hsa-miR-589-3pchr19404725240472598mer-1a40472524047275146-14.48
ADediting_1337758chr7_5495892_-ENSG00000178951.9ENST00000322357.9ZBTB7A-201hsa-miR-589-5pchr19404550340455097mer-m840455024045523160-23.52
ADediting_1337758chr7_5495892_-ENSG00000178951.9ENST00000322357.9ZBTB7A-201hsa-miR-589-5pchr19404703640470427mer-m840470354047057166-26.52
ADediting_1535951chr14_100874558_+ENSG00000178951.9ENST00000322357.9ZBTB7A-201hsa-miR-337-3pchr19404551740455237mer-m840455164045536144-10.06
ADediting_1556067chr19_40282625_-ENSG00000178951.9ENST00000322357.9ZBTB7A-201hsa-miR-641chr19404545440454618mer-1a40454544045479147-12.57
ADediting_496066chr15_66496985_-ENSG00000178951.9ENST00000322357.9ZBTB7A-201hsa-miR-4512chr19404529040452967mer-m840452894045310157-22.32
ADediting_843620chr2_207754818_+ENSG00000178951.9ENST00000322357.9ZBTB7A-201hsa-miR-4775chr19404521840452247mer-m840452174045237148-8
ADediting_843620chr2_207754818_+ENSG00000178951.9ENST00000322357.9ZBTB7A-201hsa-miR-4775chr19404769040476967mer-m840476894047710167-12.24

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1337757chr7_5495852_-ENSG00000178951.9ENST00000322357.9ZBTB7A-201hsa-miR-589-3pchr19404537440453807mer-m840453734045397145-18.19
ADediting_1471003chr9_63819626_+ENSG00000178951.9ENST00000322357.9ZBTB7A-201hsa-miR-4477bchr19404680440468118mer-1a40468044046825140-6.22
ADediting_1471004chr9_63819627_+ENSG00000178951.9ENST00000322357.9ZBTB7A-201hsa-miR-4477bchr19404680440468118mer-1a40468044046825140-6.22
ADediting_496066chr15_66496985_-ENSG00000178951.9ENST00000322357.9ZBTB7A-201hsa-miR-4512chr19404737640473827mer-m840473754047393150-24.48
ADediting_527135chr16_24203190_+ENSG00000178951.9ENST00000322357.9ZBTB7A-201hsa-miR-1273h-3pchr19404450640445127mer-m840445054044526153-24.44

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for ZBTB7A

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in miRNA.
ADeditom_IDENSTmir_IDEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in mRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in lncRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for ZBTB7A

check button Correlation between ADAR gene expression and RNA editing frequency
TissueADeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFCADediting_751683chr19_4050006_-6.35240462486872e-090.322287034285390.0001732929489595390.2117065161380761.78686322744314e-070.291215663631368
TCXADediting_751683chr19_4050006_-0.3128328874295280.08296048782733770.111955638447314-0.1303153111837198.41291534221578e-080.420541196338514
DLPFCADediting_751684chr19_4050020_-0.008000890970272830.1503753581217860.45398996623710.04268086932259585.3775448921004e-100.343192910900783
TCXADediting_751685chr19_4050021_-0.2397533943599480.09657094784885160.172646249949473-0.1119358497445474.30263011100655e-080.42903820966958
CERADediting_752197chr19_4055566_-0.01409410474514120.2000808411048590.0001239913425559370.3082902782868430.9277212849754870.00746899777362103
DLPFCADediting_752200chr19_4055633_-0.0001162815031420850.2171431190889920.005657779940827620.1568141186776031.67716782691543e-080.313611883047523
CERADediting_752200chr19_4055633_-0.003793664928339280.2350081184410013.79485536325454e-050.329671494138440.2566944760067390.0931880761924887

check button Correlation between ADAR gene expression and this gene's expression
TissueADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFC3.04631672990534e-070.2858906591446081.41863169659826e-070.2934857275663672.53454683862552e-290.580516724431831
PCC1.586788107179e-070.3683103755741712.20452351716901e-090.4158096480193370.001503286579433480.228127493458729
CER5.06357203592301e-130.5458323100388825.86228949361503e-150.5817542621641690.3018088468444420.0848660854896746
TCX7.33769153896918e-210.6696443808441933.20455495751109e-310.7743706666765310.169490064301567-0.11275909770171
FP3.81504534060458e-070.3696459380469430.2453032387548980.0875325094671429.32347310464539e-080.387212784084178
IFG3.27095389889908e-060.7856410605948922.11823564068035e-070.8347967838675040.09357637456963190.342667388903797
STG4.39716473384372e-090.5870049370587740.0001166984716558020.4080532790653131.52478814724654e-070.535585662978041

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Relation with AD stages for ZBTB7A

check button Correlation between AD stages and RNA editing frequency
TissueADeditomIDpositionP-valCoeff.

check button Correlation between AD stages and this gene's expression
TissueP-valCoeff.

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RelatedDrugs for ZBTB7A

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZBTB7A

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource
ZBTB7AC0017636Glioblastoma1CTD_human
ZBTB7AC0023467Leukemia, Myelocytic, Acute1CTD_human
ZBTB7AC0026998Acute Myeloid Leukemia, M11CTD_human
ZBTB7AC0033578Prostatic Neoplasms1CTD_human
ZBTB7AC0334588Giant Cell Glioblastoma1CTD_human
ZBTB7AC0376358Malignant neoplasm of prostate1CTD_human
ZBTB7AC1621958Glioblastoma Multiforme1CTD_human
ZBTB7AC1879321Acute Myeloid Leukemia (AML-M2)1CTD_human