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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for CUTC |
 Gene summary |
| Gene information | Gene symbol | CUTC | Gene ID | 51076 |
| Gene name | cutC copper transporter | |
| Synonyms | CGI-32 | |
| Cytomap | 10q24.2 | |
| Type of gene | protein-coding | |
| Description | copper homeostasis protein cutC homologcutC copper transporter homolog | |
| Modification date | 20200313 | |
| UniProtAcc | Q9NTM9, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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RNA A-to-I events for CUTC |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_228946(99733099, +), ADediting_228947(99733122, +), ADediting_228948(99733162, +), ADediting_228949(99734236, +), ADediting_228950(99734270, +), ADediting_228951(99734329, +), ADediting_228952(99734825, +), ADediting_228953(99734845, +), ADediting_228954(99734848, +), ADediting_228955(99734853, +), ADediting_228956(99734856, +), ADediting_228957(99734878, +), ADediting_228958(99734917, +), ADediting_228959(99734927, +), ADediting_228960(99734932, +), ADediting_228961(99734938, +), ADediting_228962(99734943, +), ADediting_228963(99734981, +), ADediting_228964(99734995, +), ADediting_228965(99735010, +), ADediting_228966(99735011, +), ADediting_228967(99735022, +), ADediting_228968(99735057, +), ADediting_228969(99735431, +), ADediting_228970(99735436, +), ADediting_228971(99735466, +), ADediting_228972(99735472, +), ADediting_228973(99735518, +), ADediting_228974(99735525, +), ADediting_228975(99735537, +), ADediting_228976(99735573, +), ADediting_228977(99735588, +), ADediting_228978(99735597, +), ADediting_228979(99735605, +), ADediting_228980(99735617, +), ADediting_228981(99737916, +), ADediting_228982(99744831, +), ADediting_228983(99745012, +), ADediting_228984(99745601, +), ADediting_228985(99745603, +), ADediting_228986(99745604, +), ADediting_228987(99745609, +), ADediting_228988(99745620, +), ADediting_228989(99745673, +), ADediting_228990(99745681, +), ADediting_228991(99745798, +), ADediting_228992(99747801, +), ADediting_228993(99751375, +), ADediting_228994(99751603, +), ADediting_228995(99751638, +), ADediting_228996(99751737, +), ADediting_228997(99751738, +), ADediting_228998(99752276, +), ADediting_228999(99755232, +), ADediting_1525164(99751382, +), ADediting_1525165(99751394, +), ADediting_1525166(99751420, +), ADediting_1525167(99751427, +), ADediting_1525168(99751649, +), ADediting_1525169(99751727, +), ADediting_1608079(99751377, +), |
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RNA editing positional annotations for CUTC using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_228946 | chr10_99733099_+ | intronic |
| ADediting_228947 | chr10_99733122_+ | intronic |
| ADediting_228948 | chr10_99733162_+ | intronic |
| ADediting_228949 | chr10_99734236_+ | intronic |
| ADediting_228950 | chr10_99734270_+ | intronic |
| ADediting_228951 | chr10_99734329_+ | intronic |
| ADediting_228952 | chr10_99734825_+ | intronic |
| ADediting_228953 | chr10_99734845_+ | intronic |
| ADediting_228954 | chr10_99734848_+ | intronic |
| ADediting_228955 | chr10_99734853_+ | intronic |
| ADediting_228956 | chr10_99734856_+ | intronic |
| ADediting_228957 | chr10_99734878_+ | intronic |
| ADediting_228958 | chr10_99734917_+ | intronic |
| ADediting_228959 | chr10_99734927_+ | intronic |
| ADediting_228960 | chr10_99734932_+ | intronic |
| ADediting_228961 | chr10_99734938_+ | intronic |
| ADediting_228962 | chr10_99734943_+ | intronic |
| ADediting_228963 | chr10_99734981_+ | intronic |
| ADediting_228964 | chr10_99734995_+ | intronic |
| ADediting_228965 | chr10_99735010_+ | intronic |
| ADediting_228966 | chr10_99735011_+ | intronic |
| ADediting_228967 | chr10_99735022_+ | intronic |
| ADediting_228968 | chr10_99735057_+ | intronic |
| ADediting_228969 | chr10_99735431_+ | intronic |
| ADediting_228970 | chr10_99735436_+ | intronic |
| ADediting_228971 | chr10_99735466_+ | intronic |
| ADediting_228972 | chr10_99735472_+ | intronic |
| ADediting_228973 | chr10_99735518_+ | intronic |
| ADediting_228974 | chr10_99735525_+ | intronic |
| ADediting_228975 | chr10_99735537_+ | intronic |
| ADediting_228976 | chr10_99735573_+ | intronic |
| ADediting_228977 | chr10_99735588_+ | intronic |
| ADediting_228978 | chr10_99735597_+ | intronic |
| ADediting_228979 | chr10_99735605_+ | intronic |
| ADediting_228980 | chr10_99735617_+ | intronic |
| ADediting_228981 | chr10_99737916_+ | intronic |
| ADediting_228982 | chr10_99744831_+ | intronic |
| ADediting_228983 | chr10_99745012_+ | intronic |
| ADediting_228984 | chr10_99745601_+ | intronic |
| ADediting_228985 | chr10_99745603_+ | intronic |
| ADediting_228986 | chr10_99745604_+ | intronic |
| ADediting_228987 | chr10_99745609_+ | intronic |
| ADediting_228988 | chr10_99745620_+ | intronic |
| ADediting_228989 | chr10_99745673_+ | intronic |
| ADediting_228990 | chr10_99745681_+ | intronic |
| ADediting_228991 | chr10_99745798_+ | intronic |
| ADediting_228992 | chr10_99747801_+ | intronic |
| ADediting_228993 | chr10_99751375_+ | intronic |
| ADediting_228994 | chr10_99751603_+ | intronic |
| ADediting_228995 | chr10_99751638_+ | intronic |
| ADediting_228996 | chr10_99751737_+ | intronic |
| ADediting_228997 | chr10_99751738_+ | intronic |
| ADediting_228998 | chr10_99752276_+ | intronic |
| ADediting_228999 | chr10_99755232_+ | intronic |
| ADediting_1525164 | chr10_99751382_+ | intronic |
| ADediting_1525165 | chr10_99751394_+ | intronic |
| ADediting_1525166 | chr10_99751420_+ | intronic |
| ADediting_1525167 | chr10_99751427_+ | intronic |
| ADediting_1525168 | chr10_99751649_+ | intronic |
| ADediting_1525169 | chr10_99751727_+ | intronic |
| ADediting_1608079 | chr10_99751377_+ | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_228946 | chr10_99733099_+ | SINE | Alu | Name=AluSx1 |
| ADediting_228947 | chr10_99733122_+ | SINE | Alu | Name=AluSx1 |
| ADediting_228948 | chr10_99733162_+ | SINE | Alu | Name=AluSx1 |
| ADediting_228949 | chr10_99734236_+ | SINE | Alu | Name=AluSq2 |
| ADediting_228950 | chr10_99734270_+ | SINE | Alu | Name=AluSq2 |
| ADediting_228951 | chr10_99734329_+ | SINE | Alu | Name=AluSq2 |
| ADediting_228952 | chr10_99734825_+ | SINE | Alu | Name=AluSz6 |
| ADediting_228953 | chr10_99734845_+ | SINE | Alu | Name=AluSz6 |
| ADediting_228954 | chr10_99734848_+ | SINE | Alu | Name=AluSz6 |
| ADediting_228955 | chr10_99734853_+ | SINE | Alu | Name=AluSz6 |
| ADediting_228956 | chr10_99734856_+ | SINE | Alu | Name=AluSz6 |
| ADediting_228957 | chr10_99734878_+ | SINE | Alu | Name=AluSz6 |
| ADediting_228958 | chr10_99734917_+ | SINE | Alu | Name=AluSz6 |
| ADediting_228959 | chr10_99734927_+ | SINE | Alu | Name=AluSz6 |
| ADediting_228960 | chr10_99734932_+ | SINE | Alu | Name=AluSz6 |
| ADediting_228961 | chr10_99734938_+ | SINE | Alu | Name=AluSz6 |
| ADediting_228962 | chr10_99734943_+ | SINE | Alu | Name=AluSz6 |
| ADediting_228963 | chr10_99734981_+ | SINE | Alu | Name=AluSz6 |
| ADediting_228964 | chr10_99734995_+ | SINE | Alu | Name=AluSz6 |
| ADediting_228965 | chr10_99735010_+ | SINE | Alu | Name=AluSz6 |
| ADediting_228966 | chr10_99735011_+ | SINE | Alu | Name=AluSz6 |
| ADediting_228967 | chr10_99735022_+ | SINE | Alu | Name=AluSz6 |
| ADediting_228968 | chr10_99735057_+ | SINE | Alu | Name=AluSz6 |
| ADediting_228969 | chr10_99735431_+ | SINE | Alu | Name=AluSz6 |
| ADediting_228970 | chr10_99735436_+ | SINE | Alu | Name=AluSz6 |
| ADediting_228971 | chr10_99735466_+ | SINE | Alu | Name=AluSz6 |
| ADediting_228972 | chr10_99735472_+ | SINE | Alu | Name=AluSz6 |
| ADediting_228973 | chr10_99735518_+ | SINE | Alu | Name=AluSz6 |
| ADediting_228974 | chr10_99735525_+ | SINE | Alu | Name=AluSz6 |
| ADediting_228975 | chr10_99735537_+ | SINE | Alu | Name=AluSz6 |
| ADediting_228976 | chr10_99735573_+ | SINE | Alu | Name=AluSz6 |
| ADediting_228977 | chr10_99735588_+ | SINE | Alu | Name=AluSz6 |
| ADediting_228978 | chr10_99735597_+ | SINE | Alu | Name=AluSz6 |
| ADediting_228979 | chr10_99735605_+ | SINE | Alu | Name=AluSz6 |
| ADediting_228980 | chr10_99735617_+ | SINE | Alu | Name=AluSz6 |
| ADediting_228981 | chr10_99737916_+ | SINE | Alu | Name=AluSp |
| ADediting_228982 | chr10_99744831_+ | SINE | Alu | Name=AluSg7 |
| ADediting_228983 | chr10_99745012_+ | SINE | Alu | Name=AluSg7 |
| ADediting_228984 | chr10_99745601_+ | SINE | Alu | Name=AluSc5 |
| ADediting_228985 | chr10_99745603_+ | SINE | Alu | Name=AluSc5 |
| ADediting_228986 | chr10_99745604_+ | SINE | Alu | Name=AluSc5 |
| ADediting_228987 | chr10_99745609_+ | SINE | Alu | Name=AluSc5 |
| ADediting_228988 | chr10_99745620_+ | SINE | Alu | Name=AluSc5 |
| ADediting_228989 | chr10_99745673_+ | SINE | Alu | Name=AluSc5 |
| ADediting_228990 | chr10_99745681_+ | SINE | Alu | Name=AluSc5 |
| ADediting_228991 | chr10_99745798_+ | SINE | Alu | Name=AluSc5 |
| ADediting_228992 | chr10_99747801_+ | SINE | Alu | Name=FLAM_C |
| ADediting_228993 | chr10_99751375_+ | SINE | Alu | Name=FLAM_A |
| ADediting_228994 | chr10_99751603_+ | SINE | Alu | Name=AluSx |
| ADediting_228995 | chr10_99751638_+ | SINE | Alu | Name=AluSx |
| ADediting_228996 | chr10_99751737_+ | SINE | Alu | Name=AluSx |
| ADediting_228997 | chr10_99751738_+ | SINE | Alu | Name=AluSx |
| ADediting_228998 | chr10_99752276_+ | SINE | Alu | Name=AluJr |
| ADediting_228999 | chr10_99755232_+ | SINE | Alu | Name=AluSz |
| ADediting_1525164 | chr10_99751382_+ | SINE | Alu | Name=FLAM_A |
| ADediting_1525165 | chr10_99751394_+ | SINE | Alu | Name=FLAM_A |
| ADediting_1525166 | chr10_99751420_+ | SINE | Alu | Name=FLAM_A |
| ADediting_1525167 | chr10_99751427_+ | SINE | Alu | Name=FLAM_A |
| ADediting_1525168 | chr10_99751649_+ | SINE | Alu | Name=AluSx |
| ADediting_1525169 | chr10_99751727_+ | SINE | Alu | Name=AluSx |
| ADediting_1608079 | chr10_99751377_+ | SINE | Alu | Name=FLAM_A |
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RNA A-to-I editing events in the alternative splicing sites for CUTC |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for CUTC |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for CUTC |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for CUTC |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for CUTC |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for CUTC |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | ADediting_228953 | chr10_99734845_+ | 0.542423505084006 | 0.0347273775975929 | 0.137741420377135 | -0.0844905092628466 | 7.6329085838578e-21 | 0.498116657253428 |
| DLPFC | ADediting_228971 | chr10_99735466_+ | 0.395714990081457 | -0.0484041964570088 | 0.012617902878568 | -0.141528928257648 | 6.03452385467536e-13 | 0.393859806665514 |
| DLPFC | ADediting_228972 | chr10_99735472_+ | 0.724361583743559 | -0.0201075654214826 | 0.0795843671501719 | -0.0997240671564189 | 3.56078885979432e-09 | 0.327331340799559 |
| DLPFC | ADediting_228977 | chr10_99735588_+ | 0.662074728246351 | 0.024919613997282 | 0.083901538034051 | -0.0983304711173756 | 5.320525161505e-21 | 0.499863512647405 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 3.39684938673044e-48 | 0.706667653847341 | 1.32808171056622e-43 | 0.681120369692051 | 0.000323191469954691 | 0.202927849832992 |
| AC | 1.01299086596265e-69 | 0.846111824597538 | 2.09436944320337e-48 | 0.760467241950717 | 4.83641796016582e-14 | 0.452815891847453 |
| PCC | 1.00547560569311e-23 | 0.643598184948874 | 7.85191690691645e-23 | 0.633589481941629 | 0.0270066537638963 | 0.160030654338482 |
| CER | 8.76942288392424e-13 | 0.541094162706974 | 0.000346106011246481 | 0.288332672084663 | 0.0721457119825794 | 0.147252610942938 |
| TCX | 2.87501498547814e-17 | 0.619519867486761 | 0.0724119360384246 | 0.14711669782238 | 1.54528047767246e-14 | 0.574306729549851 |
| FP | 1.93147517447298e-15 | 0.549651620373475 | 2.7351056823177e-09 | 0.427189505291536 | 0.179204787320975 | 0.10113184455802 |
| PG | 3.7278869811389e-52 | 0.846060445146999 | 9.98366712983838e-17 | 0.559720883868304 | 0.156292266566191 | 0.104366796058343 |
| STG | 9.65001856540351e-14 | 0.702398251336409 | 5.87065673248502e-07 | 0.513528770027586 | 0.216467814786705 | 0.136267688585165 |
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Relation with AD stages for CUTC |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| TCX | 2.50715003366155e-05 | 0.397064376203811 |
| IFG | 0.0371422932114282 | -0.418894303152609 |
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RelatedDrugs for CUTC |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CUTC |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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