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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for YARS2 |
 Gene summary |
| Gene information | Gene symbol | YARS2 | Gene ID | 51067 |
| Gene name | tyrosyl-tRNA synthetase 2 | |
| Synonyms | CGI-04|MLASA2|MT-TYRRS|TYRRS | |
| Cytomap | 12p11.21 | |
| Type of gene | protein-coding | |
| Description | tyrosine--tRNA ligase, mitochondrialtyrosine tRNA ligase 2, mitochondrialtyrosyl-tRNA synthetase 2, mitochondrial | |
| Modification date | 20200313 | |
| UniProtAcc | Q9Y2Z4, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| YARS2 | GO:0043039 | tRNA aminoacylation | 15779907|15840810|17997975 |
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RNA A-to-I events for YARS2 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_342491(32746555, -), ADediting_342492(32746600, -), ADediting_342493(32746603, -), ADediting_342494(32746610, -), ADediting_342495(32746614, -), ADediting_342496(32746630, -), ADediting_342497(32746640, -), ADediting_342498(32746659, -), ADediting_342499(32746661, -), ADediting_342500(32746662, -), ADediting_342501(32746666, -), ADediting_342502(32746676, -), ADediting_342503(32746698, -), ADediting_342504(32746702, -), ADediting_342505(32746705, -), ADediting_342506(32746706, -), ADediting_342507(32746713, -), ADediting_342508(32746714, -), ADediting_342509(32746720, -), ADediting_342510(32746731, -), ADediting_342511(32746741, -), ADediting_342512(32746751, -), ADediting_342513(32746765, -), ADediting_342514(32746779, -), ADediting_342515(32746780, -), ADediting_342516(32746789, -), ADediting_342517(32746810, -), ADediting_342518(32746811, -), ADediting_342519(32746817, -), ADediting_342520(32746829, -), ADediting_1532270(32746625, -), ADediting_1532271(32746644, -), |
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RNA editing positional annotations for YARS2 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_342491 | chr12_32746555_- | UTR3 |
| ADediting_342492 | chr12_32746600_- | UTR3 |
| ADediting_342493 | chr12_32746603_- | UTR3 |
| ADediting_342494 | chr12_32746610_- | UTR3 |
| ADediting_342495 | chr12_32746614_- | UTR3 |
| ADediting_342496 | chr12_32746630_- | UTR3 |
| ADediting_342497 | chr12_32746640_- | UTR3 |
| ADediting_342498 | chr12_32746659_- | UTR3 |
| ADediting_342499 | chr12_32746661_- | UTR3 |
| ADediting_342500 | chr12_32746662_- | UTR3 |
| ADediting_342501 | chr12_32746666_- | UTR3 |
| ADediting_342502 | chr12_32746676_- | UTR3 |
| ADediting_342503 | chr12_32746698_- | UTR3 |
| ADediting_342504 | chr12_32746702_- | UTR3 |
| ADediting_342505 | chr12_32746705_- | UTR3 |
| ADediting_342506 | chr12_32746706_- | UTR3 |
| ADediting_342507 | chr12_32746713_- | UTR3 |
| ADediting_342508 | chr12_32746714_- | UTR3 |
| ADediting_342509 | chr12_32746720_- | UTR3 |
| ADediting_342510 | chr12_32746731_- | UTR3 |
| ADediting_342511 | chr12_32746741_- | UTR3 |
| ADediting_342512 | chr12_32746751_- | UTR3 |
| ADediting_342513 | chr12_32746765_- | UTR3 |
| ADediting_342514 | chr12_32746779_- | UTR3 |
| ADediting_342515 | chr12_32746780_- | UTR3 |
| ADediting_342516 | chr12_32746789_- | UTR3 |
| ADediting_342517 | chr12_32746810_- | UTR3 |
| ADediting_342518 | chr12_32746811_- | UTR3 |
| ADediting_342519 | chr12_32746817_- | UTR3 |
| ADediting_342520 | chr12_32746829_- | UTR3 |
| ADediting_1532270 | chr12_32746625_- | UTR3 |
| ADediting_1532271 | chr12_32746644_- | UTR3 |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_342491 | chr12_32746555_- | SINE | Alu | Name=AluSz6 |
| ADediting_342492 | chr12_32746600_- | SINE | Alu | Name=AluSz6 |
| ADediting_342493 | chr12_32746603_- | SINE | Alu | Name=AluSz6 |
| ADediting_342494 | chr12_32746610_- | SINE | Alu | Name=AluSz6 |
| ADediting_342495 | chr12_32746614_- | SINE | Alu | Name=AluSz6 |
| ADediting_342496 | chr12_32746630_- | SINE | Alu | Name=AluSz6 |
| ADediting_342497 | chr12_32746640_- | SINE | Alu | Name=AluSz6 |
| ADediting_342498 | chr12_32746659_- | SINE | Alu | Name=AluSz6 |
| ADediting_342499 | chr12_32746661_- | SINE | Alu | Name=AluSz6 |
| ADediting_342500 | chr12_32746662_- | SINE | Alu | Name=AluSz6 |
| ADediting_342501 | chr12_32746666_- | SINE | Alu | Name=AluSz6 |
| ADediting_342502 | chr12_32746676_- | SINE | Alu | Name=AluSz6 |
| ADediting_342503 | chr12_32746698_- | SINE | Alu | Name=AluSz6 |
| ADediting_342504 | chr12_32746702_- | SINE | Alu | Name=AluSz6 |
| ADediting_342505 | chr12_32746705_- | SINE | Alu | Name=AluSz6 |
| ADediting_342506 | chr12_32746706_- | SINE | Alu | Name=AluSz6 |
| ADediting_342507 | chr12_32746713_- | SINE | Alu | Name=AluSz6 |
| ADediting_342508 | chr12_32746714_- | SINE | Alu | Name=AluSz6 |
| ADediting_342509 | chr12_32746720_- | SINE | Alu | Name=AluSz6 |
| ADediting_342510 | chr12_32746731_- | SINE | Alu | Name=AluSz6 |
| ADediting_342511 | chr12_32746741_- | SINE | Alu | Name=AluSz6 |
| ADediting_342512 | chr12_32746751_- | SINE | Alu | Name=AluSz6 |
| ADediting_342513 | chr12_32746765_- | SINE | Alu | Name=AluSz6 |
| ADediting_342514 | chr12_32746779_- | SINE | Alu | Name=AluSz6 |
| ADediting_342515 | chr12_32746780_- | SINE | Alu | Name=AluSz6 |
| ADediting_342516 | chr12_32746789_- | SINE | Alu | Name=AluSz6 |
| ADediting_342517 | chr12_32746810_- | SINE | Alu | Name=AluSz6 |
| ADediting_342518 | chr12_32746811_- | SINE | Alu | Name=AluSz6 |
| ADediting_342519 | chr12_32746817_- | SINE | Alu | Name=AluSz6 |
| ADediting_342520 | chr12_32746829_- | SINE | Alu | Name=AluSz6 |
| ADediting_1532270 | chr12_32746625_- | SINE | Alu | Name=AluSz6 |
| ADediting_1532271 | chr12_32746644_- | SINE | Alu | Name=AluSz6 |
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RNA A-to-I editing events in the alternative splicing sites for YARS2 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for YARS2 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for YARS2 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for YARS2 |
| RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. |
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| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1532270 | chr12_32746625_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-1306-5p | chr12 | 32746623 | 32746629 | 7mer-m8 | 32746622 | 32746643 | 140 | -17.89 |
| ADediting_342491 | chr12_32746555_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-5007-5p | chr12 | 32746550 | 32746556 | 7mer-m8 | 32746549 | 32746571 | 152 | -17.76 |
| ADediting_342492 | chr12_32746600_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-4634 | chr12 | 32746595 | 32746602 | 8mer-1a | 32746595 | 32746615 | 146 | -21.85 |
| ADediting_342494 | chr12_32746610_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-324-3p | chr12 | 32746610 | 32746616 | 7mer-m8 | 32746609 | 32746635 | 145 | -30.56 |
| ADediting_342494 | chr12_32746610_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-4690-3p | chr12 | 32746605 | 32746612 | 8mer-1a | 32746605 | 32746624 | 165 | -28.34 |
| ADediting_342494 | chr12_32746610_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-5685 | chr12 | 32746605 | 32746612 | 8mer-1a | 32746605 | 32746628 | 153 | -20.86 |
| ADediting_342498 | chr12_32746659_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-4780 | chr12 | 32746658 | 32746664 | 7mer-m8 | 32746657 | 32746678 | 145 | -17.15 |
| ADediting_342498 | chr12_32746659_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-6769a-3p | chr12 | 32746655 | 32746661 | 7mer-m8 | 32746654 | 32746674 | 140 | -14.74 |
| ADediting_342499 | chr12_32746661_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-1200 | chr12 | 32746659 | 32746665 | 7mer-m8 | 32746658 | 32746679 | 140 | -17.64 |
| ADediting_342499 | chr12_32746661_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-660-3p | chr12 | 32746657 | 32746663 | 7mer-m8 | 32746656 | 32746676 | 157 | -22.16 |
| ADediting_342499 | chr12_32746661_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-6791-3p | chr12 | 32746656 | 32746662 | 7mer-m8 | 32746655 | 32746675 | 154 | -18.48 |
| ADediting_342499 | chr12_32746661_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-6829-3p | chr12 | 32746656 | 32746662 | 7mer-m8 | 32746655 | 32746674 | 155 | -20.58 |
| ADediting_342500 | chr12_32746662_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-516a-5p | chr12 | 32746659 | 32746665 | 7mer-m8 | 32746658 | 32746680 | 142 | -18.01 |
| ADediting_342501 | chr12_32746666_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-1207-3p | chr12 | 32746666 | 32746672 | 7mer-m8 | 32746665 | 32746682 | 140 | -12.56 |
| ADediting_342501 | chr12_32746666_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-646 | chr12 | 32746664 | 32746670 | 7mer-m8 | 32746663 | 32746681 | 145 | -14.99 |
| ADediting_342502 | chr12_32746676_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-12122 | chr12 | 32746674 | 32746680 | 7mer-m8 | 32746673 | 32746697 | 158 | -18.43 |
| ADediting_342502 | chr12_32746676_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-513a-5p | chr12 | 32746675 | 32746681 | 7mer-m8 | 32746674 | 32746691 | 140 | -13.35 |
| ADediting_342502 | chr12_32746676_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-615-5p | chr12 | 32746670 | 32746676 | 7mer-1a | 32746670 | 32746691 | 140 | -25.02 |
| ADediting_342504 | chr12_32746702_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-3190-5p | chr12 | 32746696 | 32746703 | 8mer-1a | 32746696 | 32746715 | 143 | -16.58 |
| ADediting_342504 | chr12_32746702_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-548s | chr12 | 32746698 | 32746704 | 7mer-m8 | 32746697 | 32746719 | 141 | -11.32 |
| ADediting_342509 | chr12_32746720_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-4291 | chr12 | 32746715 | 32746722 | 8mer-1a | 32746715 | 32746730 | 150 | -15.5 |
| ADediting_342509 | chr12_32746720_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-922 | chr12 | 32746716 | 32746723 | 8mer-1a | 32746716 | 32746737 | 155 | -23.46 |
| ADediting_342510 | chr12_32746731_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-4508 | chr12 | 32746726 | 32746732 | 7mer-m8 | 32746725 | 32746741 | 146 | -24.45 |
| ADediting_342511 | chr12_32746741_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-3190-5p | chr12 | 32746741 | 32746747 | 7mer-m8 | 32746740 | 32746759 | 154 | -19.64 |
| ADediting_342511 | chr12_32746741_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-3692-5p | chr12 | 32746738 | 32746744 | 7mer-m8 | 32746737 | 32746759 | 164 | -34.88 |
| ADediting_342511 | chr12_32746741_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-370-3p | chr12 | 32746737 | 32746743 | 7mer-m8 | 32746736 | 32746757 | 146 | -25.87 |
| ADediting_342511 | chr12_32746741_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-6893-3p | chr12 | 32746737 | 32746743 | 7mer-m8 | 32746736 | 32746757 | 143 | -22.97 |
| ADediting_342518 | chr12_32746811_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-513a-5p | chr12 | 32746810 | 32746816 | 7mer-m8 | 32746809 | 32746826 | 144 | -17.77 |
| ADediting_342518 | chr12_32746811_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-638 | chr12 | 32746805 | 32746811 | 7mer-1a | 32746805 | 32746829 | 151 | -32.73 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_342495 | chr12_32746614_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-4772-3p | chr12 | 32746613 | 32746619 | 7mer-m8 | 32746612 | 32746633 | 147 | -18.37 |
| ADediting_342496 | chr12_32746630_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-1343-3p | chr12 | 32746627 | 32746633 | 7mer-m8 | 32746626 | 32746649 | 143 | -26.86 |
| ADediting_342496 | chr12_32746630_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-6742-3p | chr12 | 32746627 | 32746634 | 8mer-1a | 32746627 | 32746646 | 145 | -14.93 |
| ADediting_342496 | chr12_32746630_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-6783-3p | chr12 | 32746627 | 32746633 | 7mer-m8 | 32746626 | 32746646 | 146 | -16.82 |
| ADediting_342497 | chr12_32746640_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-8062 | chr12 | 32746638 | 32746644 | 7mer-m8 | 32746637 | 32746659 | 144 | -10.41 |
| ADediting_342498 | chr12_32746659_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-2682-3p | chr12 | 32746656 | 32746662 | 7mer-m8 | 32746655 | 32746677 | 155 | -16.56 |
| ADediting_342498 | chr12_32746659_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-526b-5p | chr12 | 32746659 | 32746665 | 7mer-m8 | 32746658 | 32746680 | 140 | -16.94 |
| ADediting_342498 | chr12_32746659_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-6781-3p | chr12 | 32746656 | 32746662 | 7mer-m8 | 32746655 | 32746676 | 140 | -11.15 |
| ADediting_342498 | chr12_32746659_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-6819-3p | chr12 | 32746655 | 32746661 | 7mer-m8 | 32746654 | 32746674 | 140 | -11 |
| ADediting_342498 | chr12_32746659_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-6877-3p | chr12 | 32746655 | 32746661 | 7mer-m8 | 32746654 | 32746674 | 140 | -19.23 |
| ADediting_342499 | chr12_32746661_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-2682-3p | chr12 | 32746656 | 32746662 | 7mer-m8 | 32746655 | 32746677 | 155 | -16.56 |
| ADediting_342499 | chr12_32746661_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-526b-5p | chr12 | 32746659 | 32746665 | 7mer-m8 | 32746658 | 32746680 | 140 | -16.94 |
| ADediting_342499 | chr12_32746661_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-6781-3p | chr12 | 32746656 | 32746662 | 7mer-m8 | 32746655 | 32746676 | 140 | -11.15 |
| ADediting_342500 | chr12_32746662_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-526b-5p | chr12 | 32746659 | 32746665 | 7mer-m8 | 32746658 | 32746680 | 140 | -16.94 |
| ADediting_342500 | chr12_32746662_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-6869-5p | chr12 | 32746661 | 32746668 | 8mer-1a | 32746661 | 32746683 | 148 | -19.09 |
| ADediting_342501 | chr12_32746666_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-6869-5p | chr12 | 32746661 | 32746668 | 8mer-1a | 32746661 | 32746683 | 148 | -19.09 |
| ADediting_342503 | chr12_32746698_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-3126-3p | chr12 | 32746695 | 32746701 | 7mer-m8 | 32746694 | 32746715 | 140 | -15.03 |
| ADediting_342503 | chr12_32746698_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-4794 | chr12 | 32746696 | 32746703 | 8mer-1a | 32746696 | 32746717 | 140 | -12.57 |
| ADediting_342503 | chr12_32746698_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-664a-5p | chr12 | 32746696 | 32746703 | 8mer-1a | 32746696 | 32746719 | 144 | -13.19 |
| ADediting_342504 | chr12_32746702_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-4794 | chr12 | 32746696 | 32746703 | 8mer-1a | 32746696 | 32746717 | 140 | -12.57 |
| ADediting_342504 | chr12_32746702_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-664a-5p | chr12 | 32746696 | 32746703 | 8mer-1a | 32746696 | 32746719 | 144 | -13.19 |
| ADediting_342508 | chr12_32746714_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-30a-3p | chr12 | 32746713 | 32746720 | 8mer-1a | 32746713 | 32746735 | 149 | -11.75 |
| ADediting_342508 | chr12_32746714_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-30d-3p | chr12 | 32746713 | 32746720 | 8mer-1a | 32746713 | 32746739 | 150 | -16.45 |
| ADediting_342508 | chr12_32746714_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-30e-3p | chr12 | 32746713 | 32746720 | 8mer-1a | 32746713 | 32746735 | 149 | -11.42 |
| ADediting_342509 | chr12_32746720_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-222-5p | chr12 | 32746715 | 32746722 | 8mer-1a | 32746715 | 32746736 | 140 | -10.45 |
| ADediting_342509 | chr12_32746720_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-6832-5p | chr12 | 32746719 | 32746725 | 7mer-m8 | 32746718 | 32746740 | 142 | -16.66 |
| ADediting_342510 | chr12_32746731_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-193b-5p | chr12 | 32746727 | 32746733 | 7mer-m8 | 32746726 | 32746747 | 146 | -23.38 |
| ADediting_342512 | chr12_32746751_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-3663-5p | chr12 | 32746750 | 32746756 | 7mer-m8 | 32746749 | 32746768 | 144 | -21.71 |
| ADediting_342512 | chr12_32746751_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-6131 | chr12 | 32746749 | 32746755 | 7mer-m8 | 32746748 | 32746766 | 140 | -16.72 |
| ADediting_342512 | chr12_32746751_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-6843-3p | chr12 | 32746751 | 32746757 | 7mer-m8 | 32746750 | 32746769 | 152 | -20.01 |
| ADediting_342512 | chr12_32746751_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-6848-3p | chr12 | 32746751 | 32746757 | 7mer-m8 | 32746750 | 32746767 | 142 | -15.32 |
| ADediting_342513 | chr12_32746765_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-3176 | chr12 | 32746764 | 32746770 | 7mer-m8 | 32746763 | 32746781 | 143 | -15.77 |
| ADediting_342513 | chr12_32746765_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-3922-3p | chr12 | 32746764 | 32746770 | 7mer-m8 | 32746763 | 32746783 | 148 | -18.66 |
| ADediting_342513 | chr12_32746765_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-6878-3p | chr12 | 32746765 | 32746771 | 7mer-m8 | 32746764 | 32746787 | 141 | -19.92 |
| ADediting_342516 | chr12_32746789_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-6878-3p | chr12 | 32746788 | 32746795 | 8mer-1a | 32746788 | 32746808 | 142 | -13.4 |
| ADediting_342517 | chr12_32746810_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-10399-5p | chr12 | 32746809 | 32746815 | 7mer-m8 | 32746808 | 32746829 | 148 | -10 |
| ADediting_342517 | chr12_32746810_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-5089-5p | chr12 | 32746805 | 32746811 | 7mer-m8 | 32746804 | 32746826 | 148 | -13.62 |
| ADediting_342517 | chr12_32746810_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-6504-3p | chr12 | 32746809 | 32746815 | 7mer-m8 | 32746808 | 32746829 | 145 | -14.48 |
| ADediting_342518 | chr12_32746811_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-10399-5p | chr12 | 32746809 | 32746815 | 7mer-m8 | 32746808 | 32746829 | 148 | -10 |
| ADediting_342518 | chr12_32746811_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-6504-3p | chr12 | 32746809 | 32746815 | 7mer-m8 | 32746808 | 32746829 | 145 | -14.48 |
| ADediting_342519 | chr12_32746817_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-3934-5p | chr12 | 32746813 | 32746819 | 7mer-m8 | 32746812 | 32746834 | 151 | -21 |
| ADediting_342519 | chr12_32746817_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-552-3p | chr12 | 32746811 | 32746818 | 8mer-1a | 32746811 | 32746831 | 140 | -14.36 |
| ADediting_342520 | chr12_32746829_- | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-6872-3p | chr12 | 32746826 | 32746832 | 7mer-m8 | 32746825 | 32746843 | 147 | -19.4 |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_843620 | chr2_207754818_+ | ENSG00000139131.13 | ENST00000324868.13 | YARS2-201 | hsa-miR-4775 | chr12 | 32746942 | 32746948 | 7mer-m8 | 32746941 | 32746962 | 140 | -2.73 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for YARS2 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000324868.13 | protein_coding |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_342491 | ENST00000324868.13 | chr12_32746555_- | 2106 | -752.70 | -748.90 | -782.70 |
| ADediting_342492 | ENST00000324868.13 | chr12_32746600_- | 2061 | -748.20 | -748.90 | -782.70 |
| ADediting_342493 | ENST00000324868.13 | chr12_32746603_- | 2058 | -748.90 | -748.90 | -782.70 |
| ADediting_342494 | ENST00000324868.13 | chr12_32746610_- | 2051 | -750.70 | -748.90 | -782.70 |
| ADediting_342495 | ENST00000324868.13 | chr12_32746614_- | 2047 | -748.20 | -748.90 | -782.70 |
| ADediting_1532270 | ENST00000324868.13 | chr12_32746625_- | 2036 | -748.90 | -748.90 | -782.70 |
| ADediting_342496 | ENST00000324868.13 | chr12_32746630_- | 2031 | -748.20 | -748.90 | -782.70 |
| ADediting_342497 | ENST00000324868.13 | chr12_32746640_- | 2021 | -751.00 | -748.90 | -782.70 |
| ADediting_1532271 | ENST00000324868.13 | chr12_32746644_- | 2017 | -752.90 | -748.90 | -782.70 |
| ADediting_342498 | ENST00000324868.13 | chr12_32746659_- | 2002 | -749.70 | -748.90 | -782.70 |
| ADediting_342499 | ENST00000324868.13 | chr12_32746661_- | 2000 | -753.50 | -748.90 | -782.70 |
| ADediting_342500 | ENST00000324868.13 | chr12_32746662_- | 1999 | -749.20 | -748.90 | -782.70 |
| ADediting_342501 | ENST00000324868.13 | chr12_32746666_- | 1995 | -751.00 | -748.90 | -782.70 |
| ADediting_342502 | ENST00000324868.13 | chr12_32746676_- | 1985 | -749.90 | -748.90 | -782.70 |
| ADediting_342503 | ENST00000324868.13 | chr12_32746698_- | 1963 | -748.90 | -748.90 | -782.70 |
| ADediting_342504 | ENST00000324868.13 | chr12_32746702_- | 1959 | -752.90 | -748.90 | -782.70 |
| ADediting_342505 | ENST00000324868.13 | chr12_32746705_- | 1956 | -750.80 | -748.90 | -782.70 |
| ADediting_342506 | ENST00000324868.13 | chr12_32746706_- | 1955 | -751.10 | -748.90 | -782.70 |
| ADediting_342507 | ENST00000324868.13 | chr12_32746713_- | 1948 | -751.00 | -748.90 | -782.70 |
| ADediting_342508 | ENST00000324868.13 | chr12_32746714_- | 1947 | -751.00 | -748.90 | -782.70 |
| ADediting_342509 | ENST00000324868.13 | chr12_32746720_- | 1941 | -752.60 | -748.90 | -782.70 |
| ADediting_342510 | ENST00000324868.13 | chr12_32746731_- | 1930 | -751.40 | -748.90 | -782.70 |
| ADediting_342511 | ENST00000324868.13 | chr12_32746741_- | 1920 | -750.80 | -748.90 | -782.70 |
| ADediting_342512 | ENST00000324868.13 | chr12_32746751_- | 1910 | -750.20 | -748.90 | -782.70 |
| ADediting_342513 | ENST00000324868.13 | chr12_32746765_- | 1896 | -750.30 | -748.90 | -782.70 |
| ADediting_342514 | ENST00000324868.13 | chr12_32746779_- | 1882 | -749.50 | -748.90 | -782.70 |
| ADediting_342515 | ENST00000324868.13 | chr12_32746780_- | 1881 | -748.90 | -748.90 | -782.70 |
| ADediting_342516 | ENST00000324868.13 | chr12_32746789_- | 1872 | -751.70 | -748.90 | -782.70 |
| ADediting_342517 | ENST00000324868.13 | chr12_32746810_- | 1851 | -749.10 | -748.90 | -782.70 |
| ADediting_342518 | ENST00000324868.13 | chr12_32746811_- | 1850 | -750.40 | -748.90 | -782.70 |
| ADediting_342519 | ENST00000324868.13 | chr12_32746817_- | 1844 | -748.50 | -748.90 | -782.70 |
| ADediting_342520 | ENST00000324868.13 | chr12_32746829_- | 1832 | -748.50 | -748.90 | -782.70 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for YARS2 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| CER | ADediting_342492 | chr12_32746600_- | 2.98271900381277e-06 | 0.370876034176263 | 0.0318544016976078 | 0.175346004678625 | 0.982534306592327 | 0.00180253143872403 |
| CER | ADediting_342495 | chr12_32746614_- | 3.2023419473565e-06 | 0.369799595843458 | 0.00967088776553341 | 0.210644976094602 | 0.765470124681044 | -0.024558296757898 |
| CER | ADediting_342504 | chr12_32746702_- | 5.24463762415123e-05 | 0.323986042868843 | 0.00326542295993664 | 0.238694154129519 | 0.466787468822874 | 0.0598652413383489 |
| CER | ADediting_342513 | chr12_32746765_- | 1.57895898011604e-05 | 0.344539656010307 | 0.000171600341704306 | 0.302126904548312 | 0.574967963179852 | -0.0461466834807992 |
| CER | ADediting_342519 | chr12_32746817_- | 1.18359145433226e-06 | 0.384539587842517 | 3.89474826090956e-05 | 0.329219070872421 | 0.157280949150914 | 0.116055405725599 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 9.99045420021824e-53 | 0.729437865982423 | 2.07441195275082e-48 | 0.707795660831111 | 3.58505891841768e-05 | 0.232438628762818 |
| AC | 1.11765187299359e-57 | 0.803031078512963 | 1.9276667124631e-59 | 0.810107920503174 | 2.68945988228964e-08 | 0.342690270800535 |
| PCC | 1.41900291287209e-27 | 0.682897965362953 | 7.67229168003126e-40 | 0.776978821893773 | 0.196759970083431 | 0.0938114252204425 |
| CER | 1.57496424163697e-21 | 0.678002148453334 | 2.77786602053746e-20 | 0.662188474564617 | 0.0466321359084883 | 0.16272910009889 |
| TCX | 3.09640839431554e-21 | 0.674364086371543 | 7.4149975236463e-20 | 0.656549892399248 | 0.381569358794628 | -0.0719533951232074 |
| FP | 4.51822818506088e-15 | 0.543535706311119 | 9.41720438771633e-30 | 0.720186965845685 | 0.584732855066634 | 0.0412338309241109 |
| IFG | 7.61850082375893e-05 | 0.707594220579152 | 0.000497929878669578 | 0.645115047788042 | 0.593159141071214 | 0.112261326205688 |
| PG | 1.62254357779722e-50 | 0.839015446344188 | 3.41273904489696e-35 | 0.752377968990493 | 0.389340412808462 | -0.0634822145240734 |
| STG | 1.53436567170995e-14 | 0.717870374443903 | 2.45412458451765e-16 | 0.749266931712959 | 0.459116718035508 | -0.0818645078447579 |
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Relation with AD stages for YARS2 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 0.000397814241185626 | 0.334790227845217 |
| STG | 0.00315900819984552 | -0.318414251501072 |
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RelatedDrugs for YARS2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for YARS2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| YARS2 | C0010828 | Cytopenia | 3 | GENOMICS_ENGLAND |
| YARS2 | C0158995 | Congenital anemia | 3 | GENOMICS_ENGLAND |
| YARS2 | C3150802 | MYOPATHY, LACTIC ACIDOSIS, AND SIDEROBLASTIC ANEMIA 2 | 2 | UNIPROT |
| YARS2 | C0270960 | Congenital myopathy (disorder) | 1 | GENOMICS_ENGLAND |
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