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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited versus non-edited samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with AD stages

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene


Gene summary for GLOD4

check button Gene summary
Gene informationGene symbol

GLOD4

Gene ID

51031

Gene nameglyoxalase domain containing 4
SynonymsC17orf25|CGI-150|HC71
Cytomap

17p13.3

Type of geneprotein-coding
Descriptionglyoxalase domain-containing protein 4
Modification date20200313
UniProtAcc

Q9HC38,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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RNA A-to-I events for GLOD4

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_663855(757550, -), ADediting_663856(757584, -), ADediting_663857(757595, -), ADediting_663860(757603, -), ADediting_663865(757643, -), ADediting_663866(757666, -), ADediting_663867(757672, -), ADediting_663868(757675, -), ADediting_664231(758040, -), ADediting_664296(758062, -), ADediting_664380(758116, -), ADediting_664488(758836, -), ADediting_665305(761669, -), ADediting_665321(761707, -), ADediting_665322(761708, -), ADediting_665359(761755, -), ADediting_666002(763490, -), ADediting_669023(779070, -), ADediting_669024(779085, -), ADediting_669025(779094, -), ADediting_669026(779152, -), ADediting_669027(779185, -), ADediting_669028(779190, -), ADediting_669029(779193, -), ADediting_669030(779214, -), ADediting_669031(779232, -), ADediting_669032(779270, -), ADediting_669033(779306, -), ADediting_669035(779513, -), ADediting_669036(779516, -), ADediting_669037(779543, -), ADediting_669039(779592, -), ADediting_669235(779908, -), ADediting_669236(779920, -), ADediting_669244(779975, -), ADediting_669245(779997, -), ADediting_669246(780042, -), ADediting_669247(780052, -), ADediting_669251(780117, -), ADediting_669252(780118, -), ADediting_669325(780551, -), ADediting_669327(780573, -), ADediting_669328(780576, -), ADediting_669333(780611, -), ADediting_669334(780621, -), ADediting_669338(780631, -), ADediting_669363(780696, -), ADediting_669388(780926, -), ADediting_669394(780948, -), ADediting_669409(780981, -), ADediting_669410(780993, -), ADediting_669411(781031, -), ADediting_669412(781049, -), ADediting_669413(781058, -), ADediting_669414(781059, -), ADediting_669415(781085, -), ADediting_669421(781094, -), ADediting_669429(781100, -), ADediting_669435(781114, -), ADediting_669436(781124, -), ADediting_669437(781125, -), ADediting_669438(781148, -), ADediting_669439(781158, -), ADediting_669457(781171, -), ADediting_669458(781193, -), ADediting_669459(781194, -), ADediting_1549214(758053, -), ADediting_1549215(758054, -), ADediting_1549493(779158, -), ADediting_1549494(779187, -), ADediting_1549497(779921, -), ADediting_1628738(757546, -), ADediting_1628765(761711, -), ADediting_1628814(780986, -),

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RNA editing positional annotations for GLOD4 using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred
ADediting_669363chr17_780696_-nonsynonymous SNVENST00000301328.9c.A133Gp.I45V0.0870.00.08
ADediting_669363chr17_780696_-nonsynonymous SNVENST00000574581.5c.A133Gp.I45V0.0870.00.08

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_663855chr17_757550_-intergenic
ADediting_663856chr17_757584_-intergenic
ADediting_663857chr17_757595_-intergenic
ADediting_663860chr17_757603_-intergenic
ADediting_663865chr17_757643_-intergenic
ADediting_663866chr17_757666_-intergenic
ADediting_663867chr17_757672_-intergenic
ADediting_663868chr17_757675_-intergenic
ADediting_664231chr17_758040_-intergenic
ADediting_664296chr17_758062_-intergenic
ADediting_664380chr17_758116_-downstream
ADediting_664488chr17_758836_-downstream
ADediting_665305chr17_761669_-intronic
ADediting_665321chr17_761707_-intronic
ADediting_665322chr17_761708_-intronic
ADediting_665359chr17_761755_-intronic
ADediting_666002chr17_763490_-intronic
ADediting_669023chr17_779070_-intronic
ADediting_669024chr17_779085_-intronic
ADediting_669025chr17_779094_-intronic
ADediting_669026chr17_779152_-intronic
ADediting_669027chr17_779185_-intronic
ADediting_669028chr17_779190_-intronic
ADediting_669029chr17_779193_-intronic
ADediting_669030chr17_779214_-intronic
ADediting_669031chr17_779232_-intronic
ADediting_669032chr17_779270_-intronic
ADediting_669033chr17_779306_-intronic
ADediting_669035chr17_779513_-intronic
ADediting_669036chr17_779516_-intronic
ADediting_669037chr17_779543_-intronic
ADediting_669039chr17_779592_-intronic
ADediting_669235chr17_779908_-intronic
ADediting_669236chr17_779920_-intronic
ADediting_669244chr17_779975_-intronic
ADediting_669245chr17_779997_-intronic
ADediting_669246chr17_780042_-intronic
ADediting_669247chr17_780052_-intronic
ADediting_669251chr17_780117_-intronic
ADediting_669252chr17_780118_-intronic
ADediting_669325chr17_780551_-intronic
ADediting_669327chr17_780573_-intronic
ADediting_669328chr17_780576_-intronic
ADediting_669333chr17_780611_-intronic
ADediting_669334chr17_780621_-intronic
ADediting_669338chr17_780631_-intronic
ADediting_669363chr17_780696_-exonic
ADediting_669388chr17_780926_-intronic
ADediting_669394chr17_780948_-intronic
ADediting_669409chr17_780981_-intronic
ADediting_669410chr17_780993_-intronic
ADediting_669411chr17_781031_-intronic
ADediting_669412chr17_781049_-intronic
ADediting_669413chr17_781058_-intronic
ADediting_669414chr17_781059_-intronic
ADediting_669415chr17_781085_-intronic
ADediting_669421chr17_781094_-intronic
ADediting_669429chr17_781100_-intronic
ADediting_669435chr17_781114_-intronic
ADediting_669436chr17_781124_-intronic
ADediting_669437chr17_781125_-intronic
ADediting_669438chr17_781148_-intronic
ADediting_669439chr17_781158_-intronic
ADediting_669457chr17_781171_-intronic
ADediting_669458chr17_781193_-intronic
ADediting_669459chr17_781194_-intronic
ADediting_1549214chr17_758053_-intergenic
ADediting_1549215chr17_758054_-intergenic
ADediting_1549493chr17_779158_-intronic
ADediting_1549494chr17_779187_-intronic
ADediting_1549497chr17_779921_-intronic
ADediting_1628738chr17_757546_-intergenic
ADediting_1628765chr17_761711_-intronic
ADediting_1628814chr17_780986_-intronic

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_663855chr17_757550_-SINEAluName=AluSp
ADediting_663856chr17_757584_-SINEAluName=AluSp
ADediting_663857chr17_757595_-SINEAluName=AluSp
ADediting_663860chr17_757603_-SINEAluName=AluSp
ADediting_663865chr17_757643_-SINEAluName=AluSp
ADediting_663866chr17_757666_-SINEAluName=AluSp
ADediting_663867chr17_757672_-SINEAluName=AluSp
ADediting_663868chr17_757675_-SINEAluName=AluSp
ADediting_664231chr17_758040_-SINEAluName=AluSp
ADediting_664296chr17_758062_-SINEAluName=AluSp
ADediting_664380chr17_758116_-SINEAluName=AluSp
ADediting_664488chr17_758836_-SINEAluName=AluSp
ADediting_665305chr17_761669_-SINEAluName=AluSq2
ADediting_665321chr17_761707_-SINEAluName=AluSq2
ADediting_665322chr17_761708_-SINEAluName=AluSq2
ADediting_665359chr17_761755_-SINEAluName=AluSq2
ADediting_666002chr17_763490_-SINEAluName=AluSx1
ADediting_669023chr17_779070_-SINEAluName=AluSq2
ADediting_669024chr17_779085_-SINEAluName=AluSq2
ADediting_669025chr17_779094_-SINEAluName=AluSq2
ADediting_669026chr17_779152_-SINEAluName=AluSq2
ADediting_669027chr17_779185_-SINEAluName=AluSq2
ADediting_669028chr17_779190_-SINEAluName=AluSq2
ADediting_669029chr17_779193_-SINEAluName=AluSq2
ADediting_669030chr17_779214_-SINEAluName=AluSq2
ADediting_669031chr17_779232_-SINEAluName=AluSq2
ADediting_669032chr17_779270_-SINEAluName=AluSq2
ADediting_669033chr17_779306_-SINEAluName=AluSq2
ADediting_669035chr17_779513_-SINEAluName=AluSq2
ADediting_669036chr17_779516_-SINEAluName=AluSq2
ADediting_669037chr17_779543_-SINEAluName=AluSq2
ADediting_669039chr17_779592_-SINEAluName=AluSq2
ADediting_669235chr17_779908_-SINEAluName=AluY
ADediting_669236chr17_779920_-SINEAluName=AluY
ADediting_669244chr17_779975_-SINEAluName=AluY
ADediting_669245chr17_779997_-SINEAluName=AluY
ADediting_669246chr17_780042_-SINEAluName=AluY
ADediting_669247chr17_780052_-SINEAluName=AluY
ADediting_669251chr17_780117_-SINEAluName=AluY
ADediting_669252chr17_780118_-SINEAluName=AluY
ADediting_669325chr17_780551_-SINEAluName=AluY
ADediting_669327chr17_780573_-SINEAluName=AluY
ADediting_669328chr17_780576_-SINEAluName=AluY
ADediting_669333chr17_780611_-SINEAluName=AluY
ADediting_669334chr17_780621_-SINEAluName=AluY
ADediting_669338chr17_780631_-SINEAluName=AluY
ADediting_669363chr17_780696_-SINEAluName=AluY
ADediting_669388chr17_780926_-SINEAluName=AluSq2
ADediting_669394chr17_780948_-SINEAluName=AluSq2
ADediting_669409chr17_780981_-SINEAluName=AluSq2
ADediting_669410chr17_780993_-SINEAluName=AluSq2
ADediting_669411chr17_781031_-SINEAluName=AluSq2
ADediting_669412chr17_781049_-SINEAluName=AluSq2
ADediting_669413chr17_781058_-SINEAluName=AluSq2
ADediting_669414chr17_781059_-SINEAluName=AluSq2
ADediting_669415chr17_781085_-SINEAluName=AluSq2
ADediting_669421chr17_781094_-SINEAluName=AluSq2
ADediting_669429chr17_781100_-SINEAluName=AluSq2
ADediting_669435chr17_781114_-SINEAluName=AluSq2
ADediting_669436chr17_781124_-SINEAluName=AluSq2
ADediting_669437chr17_781125_-SINEAluName=AluSq2
ADediting_669438chr17_781148_-SINEAluName=AluSq2
ADediting_669439chr17_781158_-SINEAluName=AluSq2
ADediting_669457chr17_781171_-SINEAluName=AluSq2
ADediting_669458chr17_781193_-SINEAluName=AluSq2
ADediting_669459chr17_781194_-SINEAluName=AluSq2
ADediting_1549214chr17_758053_-SINEAluName=AluSp
ADediting_1549215chr17_758054_-SINEAluName=AluSp
ADediting_1549493chr17_779158_-SINEAluName=AluSq2
ADediting_1549494chr17_779187_-SINEAluName=AluSq2
ADediting_1549497chr17_779921_-SINEAluName=AluY
ADediting_1628738chr17_757546_-SINEAluName=AluSp
ADediting_1628765chr17_761711_-SINEAluName=AluSq2
ADediting_1628814chr17_780986_-SINEAluName=AluSq2

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RNA A-to-I editing events in the alternative splicing sites for GLOD4

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for GLOD4

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
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check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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ADeditome IDChrPositoingSkipped exonENSGENSTs

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Protein coding region RNA A-to-I editings for GLOD4

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for GLOD4


check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1337758chr7_5495892_-ENSG00000167699.13ENST00000301329.10GLOD4-202hsa-miR-589-5pchr177592057592128mer-1a759205759225162-29.21

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for GLOD4

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.
ENST00000301328.9protein_codingSoverviewSoverview

check button RNA A-to-I editing in miRNA.
ADeditom_IDENSTmir_IDEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in mRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI
ADediting_669363ENST00000301328.9chr17_780696_-157-525.70-525.70-525.70

check button RNA A-to-I editing in lncRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for GLOD4

check button Correlation between ADAR gene expression and RNA editing frequency
TissueADeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFCADediting_669024chr17_779085_-3.65969521586494e-050.2321795362779140.02611632431746640.1263455369326934.02259224063707e-090.326276339934438
DLPFCADediting_669028chr17_779190_-0.003217453818427660.1668304126484420.6027084948077240.02967632709517732.12885842068937e-120.385097924896309
DLPFCADediting_669032chr17_779270_-1.28684603093316e-060.2709286135014080.0003553283973546890.2015600634424042.86263787967922e-090.329209420263636
DLPFCADediting_669037chr17_779543_-0.001005020807008840.1859289183715210.3866763335867070.04933557302315861.26077617035095e-160.446904161695868
DLPFCADediting_669325chr17_780551_-0.00272399901102140.1696834251111520.909175036676580.00650547329077477.79761413878917e-140.407552874899452
DLPFCADediting_669334chr17_780621_-0.3606804874979250.05209082110806860.291231340007376-0.06013273027107158.46972567310273e-170.449179715552518
DLPFCADediting_669338chr17_780631_-0.3162861495566210.05710075400429190.386420670226516-0.04936210820060012.49574860237102e-120.383974114904063
DLPFCADediting_669363chr17_780696_-0.07602651212158390.1009192904522020.9863423054063540.0009761927883632641.28778623811549e-100.35461884913043
DLPFCADediting_669409chr17_780981_-0.784493533540880.01559398672465640.129550734173177-0.08628389528475875.82404273411003e-130.39410283412912
DLPFCADediting_669411chr17_781031_-0.7305630555894870.01963672015362610.0635736949450946-0.1054978569917459.34251959622772e-170.448620274759455
DLPFCADediting_669412chr17_781049_-0.102520600141010.09290888221473220.465384641069474-0.04161186887074593.31948144481026e-240.533540876794106
DLPFCADediting_669413chr17_781058_-0.484773278253890.03982556754541510.238090503360562-0.06720231274300037.11685596786635e-170.450169879434663
DLPFCADediting_669414chr17_781059_-0.5126322239416250.03732481561906430.126636666119562-0.08694305641363485.19146109420793e-140.410201797909187
DLPFCADediting_669435chr17_781114_-0.01518088201873650.1378012916405720.7700187156732010.01667057896240917.16436570600904e-120.376409922728683
DLPFCADediting_669436chr17_781124_-0.1114996420513380.09057050157380610.444952270815737-0.04353949228366271.63563137131771e-090.333968696518116

check button Correlation between ADAR gene expression and this gene's expression
TissueADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFC1.95804264416057e-790.828177159976321.93620399827761e-840.8417217178302230.1286155846447430.0864941647533577
AC1.7749776467037e-1030.9209291320975491.13060605751456e-700.8490448239960311.82582118352388e-080.346574299160015
PCC7.67907172593557e-490.8255483176506741.06166158799615e-440.8048697741992020.08388707696738160.125403496956068
CER1.41472812470737e-310.7771937038023361.53887819975559e-120.5361643876002860.4673293999379780.059792581740244
TCX8.34267544069809e-330.7866575127211923.32543665264037e-220.6861782106821540.297273523448197-0.0856633445336407
FP1.17726646486339e-180.5981858758576024.86941977649544e-200.6168033385039680.609727990441754-0.0385178929994194
IFG0.01367727712626660.4864295353416930.1106462902686660.3269575034435580.0452393550752245-0.40391376743287
PG2.53132932366767e-400.786241828322511.27170072586475e-250.6702949500461220.151544186303116-0.105570803002445
STG6.07809385075506e-220.8241048433326371.6815940981573e-120.6762151983226230.675714455091185-0.0463116867691707

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Relation with AD stages for GLOD4

check button Correlation between AD stages and RNA editing frequency
TissueADeditomIDpositionP-valCoeff.

check button Correlation between AD stages and this gene's expression
TissueP-valCoeff.

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RelatedDrugs for GLOD4

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for GLOD4

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource